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British Journal of Biomedical Science

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https://www.readbyqxmd.com/read/28102104/fasting-urinary-calcium-to-creatinine-ratio-for-the-evaluation-of-calcium-nephrolithiasis-in-adults
#1
Lijing Sun, Zhiyong Guo, Jianping Shan, Gengru Jiang
No abstract text is available yet for this article.
January 19, 2017: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/28074676/potential-route-of-th17-treg-cell-dynamics-in-targeting-type-1-diabetes-and-rheumatoid-arthritis-an-autoimmune-disorder-perspective
#2
Suresh Kumar Karri, A Sheela
Cytokines, small secreted proteins, have a specific effect on the interactions and communications between cells. They play a pivotal role in the pathogenesis of autoimmune diseases. Factors in the breakdown of self-tolerance and the subsequent events leading to the induction of pathogenic responses remain unclear for most of the autoimmune diseases. Large numbers of studies have revealed a general scheme in which pro-inflammatory cytokines contribute to the initiation and propagation of autoimmune inflammation, whereas anti-inflammatory cytokines facilitate the regression of inflammation and thereby recovery from the disease...
January 11, 2017: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/27996693/assessment-of-semi-automated-nucleic-acid-testing-programme-in-a-regional-blood-transfusion-centre
#3
Kanjaksha Ghosh, Kanchan Kumar Mishra, Apeksha Trivedi, Sheetal Sosa, Krima Patel
BACKGROUND: Detection of human immunodeficiency virus type-1 (HIV-1), hepatitis-C (HCV) and hepatitis-B virus (HBV) in the blood donors is crucial. An efficient form of detection is nucleic acid testing (NAT) in blood screening. We assessed the suitability of commercial NAT testing in a developing country, focusing on the Altona RealStar assay and the method of Sacace Biotechnologies. METHODS: We have standardised and validated commercially available NAT kits with a semi-automated system for detection of HBV, HCV and HIV-1 in blood donations...
December 20, 2016: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/27976989/a-breath-ammonia-analyser-for-monitoring-patients-with-end-stage-renal-disease-on-haemodialysis
#4
J Limeres, J F Garcez, J S Marinho, A Loureiro, M Diniz, P Diz
OBJECTIVE: Breath ammonia measurement has attracted increasing interest for clinical diagnosis and metabolic status monitoring. This pilot study aims to evaluate a simple detection method to measure breath ammonia levels in haemodialysis patients. MATERIALS AND METHODS: The study group comprised 44 adults undergoing haemodialysis and a control group of 44 age- and sex-matched individuals with a glomerular filtration rate >90 mL/min. To measure breath ammonia concentration, we designed a device based on that used to monitor atmospheric air, which uses a specific colorimetric tube...
December 15, 2016: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/28206854/the-relationship-between-multidrug-resistance-protein-1-rs1045642-and-cholesterol-24-hydroxylase-rs754203-genes-polymorphism-with-type-2-diabetes-mellitus
#5
Saliha Rizvi, Syed Tasleem Raza, S Riyaz Mehdi, Zeba Siddiqi, Ale Eba, Farzana Mahdi
BACKGROUND: The involvement of genetic factors like gene polymorphisms has been found to contribute significantly to the development and progression of type 2 diabetes (T2DM). Thousands of single nucleotide polymorphisms in various genes have been found to be associated with risk of T2DM. The present study was aimed to investigate association of Multidrug resistance 1 (MDR1) (rs1045642) and CYP46A1 (rs754203) genes polymorphism with T2DM. SUBJECTS & METHODS: Study includes 333 subjects, 183 T2DM cases and 150 healthy controls...
January 2017: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/28206853/diagnostic-virology-and-patient-care-from-vaguely-interesting-to-vitally-important
#6
Sarah J Pitt, D Ian M Phillips
The existence of pathogenic viruses was inferred by experiments at the turn of the twentieth century. Key developments in detection of viruses, including electron microscopy and monolayer cell culture, were made in the middle of that century. However, in terms of patient care, the results from the virology laboratory often arrived the patient was 'better or dead'. The advent of molecular techniques, particularly polymerase chain reaction and more recently whole genome sequencing made timely and accurate diagnosis of viral infections feasible...
January 2017: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/28206852/british-journal-of-biomedical-science-in-2016-what-have-we-learned
#7
Andrew Blann
In 2016, the British Journal of Biomedical Science published 36 reports outlining specific advances in each of the various disciplines within biomedical science. These were one review, 25 original articles, 9 'In Brief' reports and one letter to the Editor. Of these, the majority were in blood science (5 in biochemistry, 7 in haematology and 2 in immunology) and infection science (8 in microbiology, 2 in virology) with a smaller number in cellular sciences (6 in cellular pathology and 2 in cytopathology). Three reports considered both biochemistry and immunology, while another reported an advance in the identification of chromosomal abnormalities...
January 2017: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/27719329/abcb1-polymorphisms-and-steroid-treatment-in-children-with-idiopathic-nephrotic-syndrome
#8
Manal A Safan, Nesreen G Elhelbawy, Dina A Midan, Heba F Khader
BACKGROUND: The most common cause of nephrotic syndrome (NS) is idiopathic nephrotic syndrome (INS), also called nephrosis. Although most patients respond to steroid therapy, there is unequal response to treatment suggesting the involvement of genetic factors. The current study was conducted to evaluate the influence of two single nucleotide polymorphisms (SNPs) in ABCB1 (C3435T and C1236T) on the steroid treatment response in INS children. MATERIALS AND METHODS: Genotyping of ABCB1 C3435T and C1236T polymorphisms by real time PCR were conducted on 120 INS children, 80 steroid sensitive (SS) and 40 steroid resistant (SR)...
October 8, 2016: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/27718888/platelet-rich-plasma-for-tissue-regeneration-can-be-stored-at-room-temperature-for-at-least-five-days
#9
Gary W Moore, James C Maloney, Robert A Archer, Kerri L Brown, Katarzyna Mayger, Elaine S Bromidge, Mitra F Najafi
BACKGROUND: Autologous platelet-rich plasma (PRP) is gaining increasing use as a wound healing promoter in a variety of clinical settings, including dentistry. Fresh PRP is often used, necessitating daily draws. The present study investigates the possibility of using stored PRP without having to freeze it by storing PRP under variable conditions and assessing growth factor release as a surrogate marker of continued viability. METHODS: Freshly drawn PRP was stored in oxygen permeable and non-oxygen permeable containers under conditions of constant agitation with or without added prostaglandin, intermittent agitation and no agitation, over an 8-day period...
October 8, 2016: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/27922433/micrornas-the-future-of-genomic-science
#10
(no author information available yet)
No abstract text is available yet for this article.
October 2016: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/27922432/mir-21-predicts-poor-prognosis-in-patients-with-osteosarcoma
#11
Xianfeng Ren, Yuqin Shen, Shuyun Zheng, JianYong Liu, Xin Jiang
BACKGROUND AND AIMS: miR-21 has been demonstrated to play an important role in tumour progression. The aim of the present study was to analyse the correlation between miR-21 expression level and clinicopathologic features, as well as to assess the prognostic significance of miR-21 in osteosarcoma. METHODS: Eighty-four pairs of osteosarcoma and corresponding non-cancerous bone tissues were obtained, and miR-21 expression levels were detected using quantitative real-time PCR (qRT-PCR)...
October 2016: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/27922431/a-multicentre-study-of-the-precision-and-accuracy-of-the-truslice-and-truslice-digital-histological-dissection-devices
#12
G E Orchard, M Shams, T Nwokie, P Fernando, C Bulut, C J Quaye, J Gabriel, Z Ramji, A Georgaki, M Watt, Z Cole, K Stewart, V McTaggart, S Padayachy, A M Long, A Ogden, C Andrews, A Birchall, F Shams, H Neesam, N Haine
BACKGROUND: Five key factors enabling a good surgical grossing technique include a flat uniformly perpendicular specimen cutting face, appropriate immobilisation of the tissue specimen during grossing, good visualisation of the cutting tissue face, sharp cutting knives and the grossing knife action. TruSlice and TruSlice Digital are new innovative tools based on a guillotine configuration. The TruSlice has plastic inserts whilst the TruSlice Digital has an electronic micrometre attached: both features enable these dissection factors to be controlled...
October 2016: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/27922430/downregulation-of-mir-124-predicts-poor-prognosis-in-pancreatic-ductal-adenocarcinoma-patients
#13
BoLin Sun, Xiaogang Liu, Yewu Gao, Li Li, ZhenLing Dong
BACKGROUND AND AIMS: miRNA-124 (miR-124) expression was known to be downregulated in patients with pancreatic ductal adenocarcinoma (PDAC). Downregulation of miR-124 was significantly associated with poor prognosis in patients with PDAC. Recent studies have shown that circulating miRNAs could be the potential biomarkers for invasive diagnostic as well as prognostic purposes. The purpose of the current study was to characterise the serum miR-124 levels and assess the clinical significance of serum miR-124 in patients with PDAC...
October 2016: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/27922429/multiplex-pcr-for-detection-of-helicobacter-pylori-infection-in-gastric-biopsies-with-lower-inflammatory-score
#14
Najmiyatul Fadilah, Alfizah Hanafiah, Hamizah Razlan, Zin Qin Wong, Isa Mohamed Rose, Md Mostafizur Rahman
BACKGROUND: No gold standard has yet been established for the diagnosis of H. pylori infection. A multiplex polymerase chain reaction (mPCR) was developed in this study for rapid, sensitive and specific detection of H. pylori from gastric biopsies. METHODS: H. pylori infections were determined by in-house rapid urease test (iRUT), culture, histology and multiplex PCR. RESULTS: A total of 140 (60.9%) from 230 patients were positive for H. pylori infection...
October 2016: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/27762791/mir-146a-gene-polymorphism-and-susceptibility-to-gastric-cancer
#15
Zahra Sadat Yadegari, Hassan Akrami, Seyed Vahid Hosseini, Nasrollah Erfani
No abstract text is available yet for this article.
October 2016: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/27477596/immunophenotyping-of-t-cells-in-the-peripheral-circulation-in-psoriasis
#16
M Priyadarssini, D Divya Priya, S Indhumathi, Medha Rajappa, Laxmisha Chandrashekar, D M Thappa
BACKGROUND: Psoriasis is a T-helper (Th)-1/Th17-mediated chronic inflammatory disease. Cytokine mediated interaction between T lymphocytes and keratinocytes lead to keratinocyte hyper-proliferation, which leads to further inflammation in the psoriatic plaques. There is an increased population of T-helper cells in the skin lesions as well as in the peripheral circulation in psoriasis. However, the relative percentage of each T-cell phenotype in the disease pathogenesis is understudied...
October 2016: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/27447335/evaluation-of-some-haemostatic-parameters-in-falciparum-malaria-and-hiv-co-infection
#17
Rebecca C Chukwuanukwu, Ernest O Ukaejiofo, Prince U Ele, Charles C Onyenekwe, Titus O Chukwuanukwu, Martin O Ifeanyichukwu
BACKGROUND: Studies from sub-Saharan Africa where malaria is endemic have observed high incidences of malaria and HIV co-infection. It has long been accepted that malaria causes alterations in haemostatic parameters and that HIV is associated with a wide range of haematological changes. We assessed the effect of the overlap of these infections on routine haemostatic parameters. METHOD: The study involved 337 subjects grouped according to their HIV and malaria status: Group 1 'Asymptomatic HIV seropositive, Plasmodium falciparum positive' (n = 61); Group 2 'Asymptomatic HIV seropositive, P...
October 2016: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/27310267/endothelial-progenitor-cells-mobilisation-after-percutaneous-coronary-intervention-a-pilot-study
#18
Melisa Santas-Álvarez, Bruno K Rodiño-Janeiro, Beatriz Paradela-Dobarro, Diego López-Otero, Juan E Viñuela-Roldán, María I Castiñeiras-Landeira, José R González-Juanatey, Ramiro Trillo-Nouche, Ezequiel Álvarez
BACKGROUND: The mobilisation process of endothelial progenitor cells (EPC) after stent implantation by percutaneous coronary intervention (PCI) is unclear because the circulating EPC levels are influenced by several pathophysiological factors. The objective was to analyse the kinetics of EPC concentration following elective PCI in patients with stable angina, and its relation with other biomarkers or parameters of cardiovascular function. METHODS: Pilot study in stable angina patients (n = 30) for elective PCI and implantation of bare-metal stent (BMS), drug-eluting stent (DES) or EPC-capturing stent (ECS)...
October 2016: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/27231984/serum-bilirubin-a-simple-routine-surrogate-marker-of-the-progression-of-chronic-kidney-disease
#19
K Moolchandani, M Priyadarssini, M Rajappa, S Parameswaran, G Revathy
BACKGROUND: Studies suggest that Chronic Kidney Disease (CKD) is a global burden health associated with significant comorbid conditions. Few biochemical parameters have gained significance in predicting the disease progression. The present work aimed to study the association of the simple biochemical parameter of serum bilirubin level with the estimated glomerular filtration rate (eGFR), and to assess their association with the co-morbid conditions in CKD. METHODS: We recruited 188 patients with CKD who attended a Nephrology out-patient department...
October 2016: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/27477890/hypophosphataemia-and-parenteral-nutrition-biochemical-monitoring-incidence-and-outcomes
#20
En C Fung, Sasala R Wickramasinghe, Julia V Panteli, Martin A Crook
AIMS: The aim of this study was to assess the incidence and clinical associations of hypophosphataemia in patients undergoing parenteral nutrition (PN) and the importance of biochemical monitoring. METHODS: Patients (n = 57) on PN were identified from pharmacy and also dietician referral records. Access to patient case files and dietetics records provided details pertaining to diagnosis, indications for PN, the level of biochemistry monitoring, and any complications incurred...
August 1, 2016: British Journal of Biomedical Science
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