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British Journal of Biomedical Science

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https://www.readbyqxmd.com/read/30421643/tlr3-and-tlr4-snp-variants-in-the-liver-disease-resulting-from-hepatitis-b-virus-and-hepatitis-c-virus-infection
#1
Ikram Sghaier, Sabrina Zidi, Leila Mouelhi, Ezzedine Ghazoueni, Etienne Brochot, Wassim Y Almawi, Besma Yacoubi Loueslati
BACKGROUND: Chronic infection with hepatitis B (HBV) and C virus (HCV) is linked with a pro-inflammatory state, predisposing to cirrhosis and liver cancer, particularly hepatocellular carcinoma (HCC). A role for toll-like receptor (TLR) signalling in hepatocarcinogenesis was recently documented. We hypothesised a link TLR3 and TLR4 polymorphisms and HCC, as surrogates for the significance of TLR signalling in the promotion and initiation of HCC. MATERIALS & METHODS: We recruited 174 HCV-infected patients, 100 HBV-infected patients, and 360 healthy control subjects...
November 13, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/30406733/influence-of-single-nucleotide-polymorphism-in-il-27-and-il-33-genes-on-breast-cancer
#2
Nazila Fathi Maroufi, Milad Matin, Nushin Ghanbari, Afshin Khorrami, Zahra Amini, Saba Haj Azimian, Alireza Isazadeh, Sina Taefehshokr, Nima Taefehshokr, Behzad Baradaran
No abstract text is available yet for this article.
November 8, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/30406716/genetic-polymorphism-of-glial-cell-derived-neurotrophic-factor-gdnf-in-male-infertility
#3
Somayeh Shabani, Farhad Mashayekhi, Seyedeh Shirin Shahangian, Zivar Salehi
No abstract text is available yet for this article.
November 8, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/30392460/clinical-diagnostic-significance-of-prealbumin-cholinesterase-and-retinol-binding-protein-in-liver-cirrhosis-combined-with-encephalopathy
#4
L Tan, Y Meng, T Zeng, Q Wang, T Long, S Wu, X Guan, H Fu, W Zheng, Y Tian, J Chen, J Yu, Y Wu, H Li, L Cao
OBJECTIVE: Hepatic encephalopathy is a common consequence of liver cirrhosis, but diagnosis can be difficult as it is based on clinical criteria alone. We hypothesised that serum prealbumin, cholinesterase and retinol binding protein (RBP) can help support the diagnosis of hepatic encephalopathy. METHODS: We enrolled 306 cirrhotic patients (110 with encephalopathy), 100 chronic hepatitis B patients and 50 healthy controls, measuring routine liver function tests (ALT, AST, GGT, ALP, and bilirubin), albumin, prothrombin time, prealbumin, cholinesterase and RBP by routine methods...
November 5, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/30379116/nitrosative-stress-and-cytokines-are-linked-with-the-severity-of-sepsis-and-organ-dysfunction
#5
Sanni Kumar, Ena Gupta, Vijay Kumar Srivastava, Sanket Kaushik, Juhi Saxena, Laxmi Kant Goyal, Sudhir Mehta, Anupam Jyoti
OBJECTIVE: An imbalance in oxidant-antioxidant status may impact into the severity of sepsis. We hypothesised links between nitrosative stress and pro-inflammatory cytokines and their correlation with the severity of sepsis and associated organ dysfunction. METHODS: The hypothesis was tested in 110 patients with sepsis (in whom a disease severity score (APACHE II), and assessment of organ failure score (SOFA) were determined) and 55 healthy volunteers. Neutrophil inducible nitric oxide synthase (iNOS) expression at mRNA and protein level were estimated by real time PCR and immuno-precipitation followed by Western blotting respectively...
October 31, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/30175654/association-of-genetic-polymorphisms-of-chemokines-and-their-receptors-with-clearance-or-persistence-of-hepatitis-c-virus-infection
#6
M El-Bendary, M Neamatallah, H Elalfy, T Besheer, M El-Setouhy, M M Youssef, M Zein, D Elhammady, A Hegazy, G Esmat
BACKGROUND: Polymorphisms of certain genes may have an effect on either persistence of infection or spontaneous clearance of hepatitis C virus (HCV). We hypothesized that one or more variants of chemokines (CCL2 and CCL5) and chemokine receptors (CC chemokine receptor type 2 [CCR2]) genes are associated with the susceptibility to HCV infection. METHODS: We recruited 1460 patients with chronic HCV (CHC), 108 subjects with spontaneous virus clearance (SVC) and 1446 individuals as a healthy control group...
October 29, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/30092718/snp-rs10800708-within-the-kif14-mirna-binding-site-is-linked-with-breast-cancer
#7
A Shasttiri, M Rostamian Delavar, M Baghi, M Dehghani Ashkezari, K Ghaedi
No abstract text is available yet for this article.
October 26, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/30295133/british-journal-of-biomedical-science-in-2018-what-have-we-learned
#8
Andrew Blann
In 2018 the British Journal of Biomedical Science published one guideline (in reproductive science) and 40 research articles in the various disciplines the comprise biomedical science. The latter were 24 original articles and 16 'In Brief' short reports. Of these, 23 are of note to only one of the sub-disciplines (seven each to biochemists and microbiologists, six to cell pathologists, and one each to cytologists, immunologists and reproductive scientists). Reflecting the increasing complexity of laboratory science, thirteen papers crossed one boundary (three papers each relevant to biochemists and immunologists, and to haematologists and biochemists), whilst four papers were relevant to three or more disciplines...
October 8, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/30269656/a-functional-genetic-variant-in-gas5-lncrna-rs145204276-modulates-p27-kip1-expression-and-confers-risk-for-gastric-cancer
#9
Keyvan Aminian, Farhad Mashayekhi, Laleh Mirzanejad, Zivar Salehi
OBJECTIVE: There has been extensive progress in the identification of single nucleotide polymorphisms (SNPs) affecting susceptibility to gastric cancer in recent years. We hypothesised a functional polymorphism (rs145204276) in GAS5 lncRNA (growth arrest specific transcript 5 long noncoding RNA) in gastric cancer that may modulate the p27Kip1 protein level. MATERIAL AND METHODS: We recruited 130 gastric cancer cases and 230 age and sex matched healthy control subjects...
October 1, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/30253706/association-of-sdf1%C3%AE-g801a-and-gnb3-c825t-polymorphisms-with-the-incidence-and-severity-of-coronary-artery-disease
#10
A Eba, S T Raza, M Abbas, S Rizvi, M Rajput, F Mahdi
No abstract text is available yet for this article.
September 26, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/30203720/microrna-935-is-reduced-in-non-small-cell-lung-cancer-tissue-is-linked-to-poor-outcome-and-acts-on-signal-transduction-mediator-e2f7-and-the-akt-pathway
#11
C Wang, S Li, J Xu, W Niu, S Li
BACKGROUND: A potential role for microRNA-935 (miR-935) has been identified in several cancers but not in non-small cell lung cancer (NSCLC). We hypothesised changes in miR-935 in NSCLC, and proposed mechanisms that may further explain its role in carcinogenesis. METHODS: NSCLC tissue and nearby normal tissue was obtained from 101 patients and was probed by qRT-PCR for miR-935 expression. The role of miR-935 and a potential target (signal transduction factor E2F7) was determined in cell lines by a dual luciferase assay...
September 11, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29991336/development-of-a-multiplex-two-gene-real-time-pcr-assay-for-accurate-detection-of-klebsiella-pneumoniae
#12
Y Dou, L Li, J Du, Y He, R Chen, Y Li, C Ma, H Liu
No abstract text is available yet for this article.
August 22, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/30211669/role-of-variants-rs5030717-and-rs5030718-of-tlr4-in-the-risk-prediction-of-nephropathy-hypertension-and-dyslipidaemia-in-type-2-diabetes-mellitus
#13
S A Abbas, S T Raza, S S Mir, Z Siddiqi, A Zaidi, Z H Zaidi, F Mahdi
BACKGROUND: Type 2 diabetes mellitus describes a metabolic disorder characterised by prolonged elevated blood glucose that brings a risk of developing microvascular and macrovascular disease. Several factors, such as dysregulation of the Toll-like receptor 4 (TLR-4), are reputed to contribute to the multiple pathophysiological disturbances responsible for impaired glucose homeostasis. We hypothesised that variants rs5030717 and rs5030718 of TLR4 are associated with diabetic nephropathy, hypertension and dyslipidaemia...
October 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/30105943/bpi-anca-in-chronic-obstructive-pulmonary-disease-with-pulmonary-pseudomonas-aeruginosa-colonisation-a-novel-indicator-of-poor-prognosis
#14
Y Tian, T Zeng, L Tan, Y Wu, J Yu, J Huang, Z Pei
No abstract text is available yet for this article.
October 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/30079841/serum-leptin-and-homeostasis-model-assessment-ir-as-novel-predictors-of-early-liver-fibrosis-in-chronic-hepatitis-b-virus-infection
#15
N Mousa, A Abdel-Razik, T Sheta, W Shabana, S Zakaria, M Awad, M Abd Elsalam, N El-Wakeel, W Elkashef, N Effat, A Elgamal, A G Deiab, W Eldars
BACKGROUND: The relationship between hepatitis B virus (HBV) infection, leptin and insulin resistance remains unclear. We hypothesised links between serum leptin and insulin resistance in non-diabetic patients with chronic viral hepatitis B infection and their relation to liver fibrosis. METHODS: We recruited 190 untreated patients with chronic HBV infection and 72 healthy controls. Serum leptin, fasting glucose, insulin, liver function tests (LFTs), C-peptide and Homeostasis model assessment-IR (HOMA-IR) were measured/calculated by ELISA and standard techniques...
October 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/30058458/prognostic-significance-of-soluble-major-histocompatibility-complex-class-i-related-chain-a-smica-in-gastric-cancer
#16
P Zhao, D Chen, H Cheng
No abstract text is available yet for this article.
October 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29991324/monocyte-granulocyte-to-lymphocyte-ratio-and-the-meld-score-as-predictors-for-early-recurrence-of-hepatocellular-carcinoma-after-trans-arterial-chemoembolization
#17
H Elalfy, T Besheer, M A El-Maksoud, K Farid, M Elegezy, A M El Nakib, M A El-Aziz, A A El-Khalek, A El-Morsy, A Elmokadem, A Z Elsamanoudy, M El-Bendary
BACKGROUND: The first-line treatment option for intermediate-stage hepatocellular carcinoma is trans-arterial chemoembolization (TACE). Blood indices, such as lymphocyte/monocyte ratio (LMR), lymphocyte count, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte-granulocyte/lymphocyte ratio (MGLR) and red blood cell distribution width (RDW), are prognostic biomarkers in certain diseases. The model for end-stage liver disease (MELD) and Child-Turcotte-Pugh (CTP) scores have been designed for patients with cirrhosis waiting for liver transplantation and in patients with hepatocellular carcinoma...
October 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29962277/molecular-characterization-of-plasmid-encoded-blatem-blashv-and-blactx-m-among-extended-spectrum-%C3%AE-lactamases-esbls-producing-acinetobacter-baumannii
#18
Asg Smiline, J P Vijayashree, A Paramasivam
No abstract text is available yet for this article.
October 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29947302/the-association-of-single-nucleotide-polymorphisms-of-toll-like-receptor-3-toll-like-receptor-7-and-toll-like-receptor-8-genes-with-the-susceptibility-to-hcv-infection
#19
M El-Bendary, M Neamatallah, H Elalfy, T Besheer, A Elkholi, M El-Diasty, M Elsareef, M Zahran, B El-Aarag, A Gomaa, D Elhammady, M El-Setouhy, A Hegazy, G Esmat
BACKGROUND: Single nucleotide polymorphisms (SNPs) of Toll-like receptors (TLRs) are linked with functional modification of cytokine responses. In chronic hepatitis C virus (HCV) infection, studies of TLR polymorphisms have primarily targeted receptor pathways implicated in viral immune responses. We hypothesized that one or more variant(s) of TLR3, TLR7 and TLR8 are associated with different outcomes of HCV infection. MATERIALS & METHODS: A total of 3368 subjects from 850 families were recruited and divided into three main groups categorized as chronic HCV CHC spontaneous viral clearance (SVC), and controls...
October 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29943682/impact-of-non-alcoholic-fatty-liver-disease-on-pregnancy
#20
N Mousa, A Abdel-Razik, M Shams, T Sheta, S Zakaria, W Shabana, N Effat, M El-Diasty, S Abed, M Abd Elsalam, M Awad, M Salah, N El-Wakeel, A G Deiab, W Eldars
No abstract text is available yet for this article.
October 2018: British Journal of Biomedical Science
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