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British Journal of Biomedical Science

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https://www.readbyqxmd.com/read/30211669/role-of-variants-rs5030717-and-rs5030718-of-tlr4-in-the-risk-prediction-of-nephropathy-hypertension-and-dyslipidaemia-in-type-2-diabetes-mellitus
#1
S A Abbas, S T Raza, S S Mir, Z Siddiqi, A Zaidi, Z H Zaidi, F Mahdi
BACKGROUND: Type 2 diabetes mellitus describes a metabolic disorder characterised by prolonged elevated blood glucose that brings a risk of developing microvascular and macrovascular disease. Several factors, such as dysregulation of the Toll-like receptor 4 (TLR-4), are reputed to contribute to the multiple pathophysiological disturbances responsible for impaired glucose homeostasis. We hypothesised that variants rs5030717 and rs5030718 of TLR4 are associated with diabetic nephropathy, hypertension and dyslipidaemia...
September 13, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/30105943/bpi-anca-in-chronic-obstructive-pulmonary-disease-with-pulmonary-pseudomonas-aeruginosa-colonisation-a-novel-indicator-of-poor-prognosis
#2
Y Tian, T Zeng, L Tan, Y Wu, J Yu, J Huang, Z Pei
No abstract text is available yet for this article.
September 13, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/30203720/microrna-935-is-reduced-in-non-small-cell-lung-cancer-tissue-is-linked-poor-outcome-and-acts-on-signal-transduction-mediator-e2f7-and-the-akt-pathway
#3
C Wang, S Li, J Xu, W Niu, S Li
BACKGROUND: A potential role for microRNA-935 (miR-935) has been identified in several cancers but not in non-small cell lung cancer (NSCLC). We hypothesised changes in miR-935 in NSCLC, and proposed mechanisms that may further explain its role in carcinogenesis. METHODS: NCSLC tissue and nearby normal tissue was obtained from 101 patients and was probed by qRT-PCR for miR-935 expression. The role of miR-935 and a potential target (signal transduction factor E2F7) was determined in cell lines by a dual luciferase assay...
September 11, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/30079841/serum-leptin-and-homeostasis-model-assessment-ir-as-novel-predictors-of-early-liver-fibrosis-in-chronic-hepatitis-b-virus-infection
#4
N Mousa, A Abdel-Razik, T Sheta, W Shabana, S Zakaria, M Awad, M Abd Elsalam, N El-Wakeel, W Elkashef, N Effat, A Elgamal, A G Deiab, W Eldars
BACKGROUND: The relationship between hepatitis B virus (HBV) infection, leptin and insulin resistance remains unclear. We hypothesised links between serum leptin and insulin resistance in non-diabetic patients with chronic viral hepatitis B infection and their relation to liver fibrosis. METHODS: We recruited 190 untreated patients with chronic HBV infection and 72 healthy controls. Serum leptin, fasting glucose, insulin, liver function tests (LFTs), C-peptide and Homeostasis model assessment-IR (HOMA-IR) were measured/calculated by ELISA and standard techniques...
September 7, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/30058458/prognostic-significance-of-soluble-major-histocompatibility-complex-class-i-related-chain-a-smica-in-gastric-cancer
#5
P Zhao, D Chen, H Cheng
No abstract text is available yet for this article.
September 6, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/30175654/association-of-genetic-polymorphisms-of-chemokines-and-their-receptors-with-clearance-or-persistence-of-hepatitis-c-virus-infection
#6
M El-Bendary, M Neamatallah, H Elalfy, T Besheer, M El-Setouhy, M Mahfouz, M Zein, D Elhammady, A Hegazy, G Esmat
BACKGROUND: Polymorphisms of certain genes may have an effect on either persistence of infection or spontaneous clearance of hepatitis C virus (HCV). We hypothesized that one or more variants of chemokines (CCL2 and CCL5) and chemokine receptors (CCR2) genes are associated with the susceptibility to HCV infection. METHODS: We recruited 1460 patients with chronic HCV (CHC), 108 subjects with spontaneous virus clearance (SVC), and 1446 individuals as a healthy control group...
September 3, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29947302/the-association-of-single-nucleotide-polymorphisms-of-toll-like-receptor-3-toll-like-receptor-7-and-toll-like-receptor-8-genes-with-the-susceptibility-to-hcv-infection
#7
M El-Bendary, M Neamatallah, H Elalfy, T Besheer, A Elkholi, M El-Diasty, M Elsareef, M Zahran, B El-Aarag, A Gomaa, D Elhammady, M El-Setouhy, A Hegazy, G Esmat
BACKGROUND: Single nucleotide polymorphisms (SNPs) of Toll-like receptors (TLRs) are linked with functional modification of cytokine responses. In chronic hepatitis C virus (HCV) infection, studies of TLR polymorphisms have primarily targeted receptor pathways implicated in viral immune responses. We hypothesized that one or more variant(s) of TLR3, TLR7 and TLR8 are associated with different outcomes of HCV infection. MATERIALS & METHODS: A total of 3368 subjects from 850 families were recruited and divided into three main groups categorized as chronic HCV CHC spontaneous viral clearance (SVC), and controls...
August 23, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29991336/development-of-a-multiplex-two-gene-real-time-pcr-assay-for-accurate-detection-of-klebsiella-pneumoniae
#8
Y Dou, L Li, J Du, Y He, R Chen, Y Li, C Ma, H Liu
No abstract text is available yet for this article.
August 22, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29991324/monocyte-granulocyte-to-lymphocyte-ratio-and-the-meld-score-as-predictors-for-early-recurrence-of-hepatocellular-carcinoma-after-trans-arterial-chemoembolization
#9
H Elalfy, T Besheer, M A El-Maksoud, K Farid, M Elegezy, A M El Nakib, M A El-Aziz, A A El-Khalek, A El-Morsy, A Elmokadem, A Z Elsamanoudy, M El-Bendary
BACKGROUND: The first-line treatment option for intermediate-stage hepatocellular carcinoma is trans-arterial chemoembolization (TACE). Blood indices, such as lymphocyte/monocyte ratio (LMR), lymphocyte count, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte-granulocyte/lymphocyte ratio (MGLR) and red blood cell distribution width (RDW), are prognostic biomarkers in certain diseases. The model for end-stage liver disease (MELD) and Child-Turcotte-Pugh (CTP) scores have been designed for patients with cirrhosis waiting for liver transplantation and in patients with hepatocellular carcinoma...
August 21, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29914308/il-28b-rs12979860-polymorphism-affect-the-course-of-chronic-hepatitis-and-the-development-of-hcc-in-egyptian-patients-with-hepatitis-c-type-4
#10
A M Attallah, D Omran, M S Marie, Mohamed Abdelrazek, A Salama, R El Essawey, L Mobarak, S Maklad, A Omar
BACKGROUND: A single nucleotide polymorphism (SNP) in the interleukin 28B (IL28B) gene may alter the trajectory of hepatitis C virus (HCV) chronic infection. Several studies have sought to determine a link between IL28B rs12979860 SNP and the development of HCV-related hepatocellular carcinoma (HCC), but with variable results, and consensus is awaited. We hypothesised that IL28B rs12979860 SNP is linked to HCC in patients with HCV type 4. METHODS: IL28B genotyping of 300 patients with HCV-related fibrosis (n = 100), cirrhosis (n = 100) and HCC (n = 100) was carried out and the results were analysed to determine the association between the IL28B genotype and clinical outcome...
August 21, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29938592/influence-of-single-nucleotide-polymorphisms-in-pri-mir-124-1-and-stat3-genes-on-gastric-cancer-susceptibility
#11
S M Mirnoori, S S Shahangian, Zivar Salehi, F Mashayekhi, S Talesh Sasani, H S Saedi
INTRODUCTION: MicroRNAs (miRNAs) are small ribonucleic acids that modulate the expression of downstream target genes. There is considerable evidence of their involvement in many malignancies, such as oesophageal and gastric. We hypothesised altered expressions of pri-miR-124-1 rs531564 and STAT3 rs1053023 polymorphisms in gastric cancer. MATERIALS AND METHODS: Genomic DNA was extracted from peripheral blood of 250 patients with gastric cancer and 310 healthy individuals...
August 17, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29909733/impact-of-gstm1-gstt1-and-gstp1-genes-polymorphisms-on-clinical-toxicities-and-response-to-concomitant-chemoradiotherapy-in-cervical-cancer
#12
M Abbas, V S Kushwaha, K Srivastava, S T Raza, M Banerjee
BACKGROUND: Certain forms of chemoradiotherapy generate toxic reactive oxygen species, which may be ameliorated by antioxidant enzymes such as glutathione S-transferase (GST). Genetic polymorphisms of GST may predict treatment outcomes and can be used as genetic marker to screen patients before treatment. We hypothesised an effect of GST polymorphisms on the response and toxicities produced by chemoradiation therapy. MATERIALS AND METHODS: GST polymorphisms were determined by multiplex polymerase chain reaction and PCR-restriction fragment length polymorphism (PCR-RFLP) in 227 women with cervical cancer receiving cisplatin based chemoradiotherapy...
August 17, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29962277/molecular-characterization-of-plasmid-encoded-blatem-blashv-and-blactx-m-among-extended-spectrum-%C3%AE-lactamases-esbls-producing-acinetobacter-baumannii
#13
Asg Smiline, J P Vijayashree, A Paramasivam
No abstract text is available yet for this article.
August 16, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/30092718/snp-rs10800708-within-the-kif14-mirna-binding-site-is-linked-with-breast-cancer
#14
A Shasttiri, Mahsa Rostamian Delavar, M Baghi, Mahmoud Dehghani Ashkezari, K Ghaedi
No abstract text is available yet for this article.
August 10, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29943682/impact-of-non-alcoholic-fatty-liver-disease-on-pregnancy
#15
N Mousa, A Abdel-Razik, M Shams, T Sheta, S Zakaria, W Shabana, N Effat, M El-Diasty, S Abed, M Abd Elsalam, M Awad, M Salah, N El-Wakeel, A G Deiab, W Eldars
No abstract text is available yet for this article.
August 6, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29968522/a-method-for-improving-the-accuracy-of-non-invasive-prenatal-screening-by-cell-free-foetal-dna-size-selection
#16
Q Z He, X J Wu, Q Y He, J J Xiang, C H Zhang, L Lu, T Wang, H Li
Background Non-invasive prenatal screening (NIPS) using cell-free foetal DNA (cfDNA) has been widely used for identifying common foetal aneuploidies (e.g. trisomy 21 (T21), trisomy (T18) and trisomy 13 (T13)) in clinical practice. The sensitivity and specificity of NIPS exceeds 99%, but the positive prediction value (PPV) is approximately 70% (combined T21, T18 and T13). Thus, some 30% of pregnant women who have positive NIPS results are eventually identified as normal by amniocentesis. These women therefore must undertake needless invasive tests and risk miscarrying healthy babies because of false positive NIPS results...
July 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29893194/genetic-polymorphisms-in-kcnj11-e23k-rs5219-and-sdf-1%C3%AE-g801a-rs1801157-genes-are-associated-with-the-risk-of-type-2-diabetes-mellitus
#17
S Rizvi, S T Raza, F Mahdi, S P Singh, M Rajput, Q Rahman
Background Type 2 diabetes mellitus (T2DM) is a global major health problem resulting from interaction of environmental and genetic factors, examples of the latter being KCNJ11 (coding for part of the ATP-sensitive potassium channel) and SDF-1β (coding for chemokine CXCL12). Our case-control study was conducted to assess whether recessive, dominant or additive genotype model associations of KCNJ11 (E23K, rs5219) and SDF-1β (G801A, rs1801157) were more strongly linked to type 2 diabetes. Subjects & Methods Genetic polymorphism analysis was performed by polymerase chain reaction-restriction fragment length polymorphism...
July 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29893189/the-gamma-glutamyl-transferase-to-platelet-ratio-and-the-fib-4-score-are-noninvasive-markers-to-determine-the-severity-of-liver-fibrosis-in-chronic-hepatitis-b-infection
#18
J Lee, M Y Kim, S H Kang, J Kim, Y Uh, K J Yoon, H S Kim
Objective Noninvasive liver fibrosis evaluation is an important issue in chronic hepatitis B infection, and may be assessed using transient elastography (Fibroscan) or with blood markers. We compared the value of Fibroscan with that of a panel of routine serum markers. Materials and methods We recruited 278 chronic hepatitis B patients who underwent Fibroscan and HBV DNA testing. Fibroscan assessments were made, and blood taken for the measurement of the gamma-glutamyl transferase (GGT) to platelet ratio (GPR), platelet count, aspartate aminotransaminase (AST), alanine aminotransaminase (ALT), international normalised ratio (INR), total cholesterol, trigylcerides, bilirubin, mean platelet volume (MPV), AST to platelet ratio index (APRI) and neutrophil to lymphocyte ratio...
July 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29734875/clinical-value-of-a-diagnostic-score-for-colon-cancer-based-on-serum-cea-ca19-9-cytokeratin-1-and-mucin-1
#19
A M Attallah, M El-Far, A R Ibrahim, M A El-Desouky, M M Omran, M S Elbendary, K A Attallah, E R Qura, S O Abdallah
BACKGROUND: Although established markers such as CEA and CA19-9 are important for diagnosing early stages of colon cancer, they are not ideal. Developing promising markers include cytokeratin 1 (CK1) and mucin-1 (MUC1), but the combined value of each of these markers is unclear. We therefore evaluated the value of a combined laboratory-based score of these four markers in the diagnosis of colon cancer. METHODS: Two hundred patients who had undergone colonoscopic examination (150 colon cancer, 50 benign growths) were recruited...
July 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29668362/the-role-of-rs267606943-polymorphism-in-the-prolidase-gene-and-plasma-prolidase-in-polycystic-ovary-syndrome
#20
R Bhatnager, S Nanda, A S Dang
No abstract text is available yet for this article.
July 2018: British Journal of Biomedical Science
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