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British Journal of Biomedical Science

Zahra Sadat Yadegari, Hassan Akrami, Seyed Vahid Hosseini, Nasrollah Erfani
No abstract text is available yet for this article.
October 20, 2016: British Journal of Biomedical Science
Manal A Safan, Nesreen G Elhelbawy, Dina A Midan, Heba F Khader
BACKGROUND: The most common cause of nephrotic syndrome (NS) is idiopathic nephrotic syndrome (INS), also called nephrosis. Although most patients respond to steroid therapy, there is unequal response to treatment suggesting the involvement of genetic factors. The current study was conducted to evaluate the influence of two single nucleotide polymorphisms (SNPs) in ABCB1 (C3435T and C1236T) on the steroid treatment response in INS children. MATERIALS AND METHODS: Genotyping of ABCB1 C3435T and C1236T polymorphisms by real time PCR were conducted on 120 INS children, 80 steroid sensitive (SS) and 40 steroid resistant (SR)...
October 8, 2016: British Journal of Biomedical Science
Gary W Moore, James C Maloney, Robert A Archer, Kerri L Brown, Katarzyna Mayger, Elaine S Bromidge, Mitra F Najafi
BACKGROUND: Autologous platelet-rich plasma (PRP) is gaining increasing use as a wound healing promoter in a variety of clinical settings, including dentistry. Fresh PRP is often used, necessitating daily draws. The present study investigates the possibility of using stored PRP without having to freeze it by storing PRP under variable conditions and assessing growth factor release as a surrogate marker of continued viability. METHODS: Freshly drawn PRP was stored in oxygen permeable and non-oxygen permeable containers under conditions of constant agitation with or without added prostaglandin, intermittent agitation and no agitation, over an 8-day period...
October 8, 2016: British Journal of Biomedical Science
En C Fung, Sasala R Wickramasinghe, Julia V Panteli, Martin A Crook
AIMS: The aim of this study was to assess the incidence and clinical associations of hypophosphataemia in patients undergoing parenteral nutrition (PN) and the importance of biochemical monitoring. METHODS: Patients (n = 57) on PN were identified from pharmacy and also dietician referral records. Access to patient case files and dietetics records provided details pertaining to diagnosis, indications for PN, the level of biochemistry monitoring, and any complications incurred...
August 1, 2016: British Journal of Biomedical Science
M Priyadarssini, D Divya Priya, S Indhumathi, Medha Rajappa, Laxmisha Chandrashekar, D M Thappa
BACKGROUND: Psoriasis is a T-helper (Th)-1/Th17-mediated chronic inflammatory disease. Cytokine mediated interaction between T lymphocytes and keratinocytes lead to keratinocyte hyper-proliferation, which leads to further inflammation in the psoriatic plaques. There is an increased population of T-helper cells in the skin lesions as well as in the peripheral circulation in psoriasis. However, the relative percentage of each T-cell phenotype in the disease pathogenesis is understudied...
August 1, 2016: British Journal of Biomedical Science
Rebecca C Chukwuanukwu, Ernest O Ukaejiofo, Prince U Ele, Charles C Onyenekwe, Titus O Chukwuanukwu, Martin O Ifeanyichukwu
BACKGROUND: Studies from sub-Saharan Africa where malaria is endemic have observed high incidences of malaria and HIV co-infection. It has long been accepted that malaria causes alterations in haemostatic parameters and that HIV is associated with a wide range of haematological changes. We assessed the effect of the overlap of these infections on routine haemostatic parameters. METHOD: The study involved 337 subjects grouped according to their HIV and malaria status: Group 1 'Asymptomatic HIV seropositive, Plasmodium falciparum positive' (n = 61); Group 2 'Asymptomatic HIV seropositive, P...
July 22, 2016: British Journal of Biomedical Science
Yuanyuan Zhang, Qingqing Qian, Guang Qian, Guangchun Sun
BACKGROUND: The aims of this study were to investigate the effects of rivaroxaban on routine coagulation assays using our local, widely available, reagents and to study the relationship between sensitive coagulation assays and bleeding risk caused by rivaroxaban. METHODS: Prothrombin time (PT), activated partial thromboplastin time (APTT) and anti-factor Xa (FXa) chromogenic assays (Biophen DiXaI) and inhibition of FXa activity were performed in normal pooled plasma (NPP) spiked with rivaroxaban and plasma samples from patients treated with rivaroxaban...
July 11, 2016: British Journal of Biomedical Science
Fariba Mahmoudi, Behzad Baradaran, Alireza Dehnad, Dariush Shanehbandi, Leila Mohamed Khosroshahi, Mahyar Aghapour
BACKGROUND: The natural products derived from micro-organisms are potential candidates for the discovery of novel drugs. Streptomyces bacteria are prolific sources of secondary metabolites with a wide variety of biological activities. Streptomyces calvus (S. calvus) is one strain of this genus and may be an appropriate candidate for isolating new compounds. In this study, the immunomodulatory effects of S. calvus secondary metabolites on the expression of various cytokine genes by human peripheral blood mononuclear cells (PBMCs) were evaluated...
July 3, 2016: British Journal of Biomedical Science
Jong-Han Lee, Sungwook Song, Soo-Young Yoon, Chae Seung Lim, Jae-Woo Song, Hyon-Suk Kim
No abstract text is available yet for this article.
July 2016: British Journal of Biomedical Science
Meichun Zhang, Rongrong Zhai, Jie Liu, Hui Guang, Benzhong Li, Dong Chen
No abstract text is available yet for this article.
July 2016: British Journal of Biomedical Science
Yi-Ding Chen, Ci-You Huang, Hai-Ying Liu, Wei-Feng Yao, Wei-Guo Wu, Yu-Lian Lu, Wen Wang
BACKGROUND: The chemokine (C-X3-C motif) ligand 1 (CX3CL1), also called fractalkine (FKN), has recently been reported to be involved in osteoclastogenic process and pathological bone destruction. OBJECTIVE: This study aimed to investigate the link between serum CX3CL1/FKN levels with disease progression of postmenopausal osteoporotic patients. METHODS: A total of 53 women with postmenopausal osteoporosis (PMOP group), 51 postmenopausal non-osteoporotic female patients (PMNOP group) and 50 premenopausal non-osteoporotic healthy women of childbearing age (control group) were enrolled in the study...
July 2016: British Journal of Biomedical Science
Haniyeh Fooladinezhad, Hossein Khanahmad, Mazdak Ganjalikhani-Hakemi, Abbas Doosti
BACKGROUND: Uncontrolled proliferation and accumulation of leukaemic stem cells (LSCs) in bone marrow leads to acute myeloma leukaemia (AML). T cell immunoglobulin and mucine domain (TIM)-3 is a specific surface marker for LSCs and is highly expressed on LSCs compared with normal bone marrow cells, haematopoietic stem cells. Studies have indicated that microRNAs can affect AML progression through targeting different genes expressions like TIM-3. So, based on bioinformatics assessments, we predicted that miR-330-5p may highly inhibit TIM-3 expression...
June 24, 2016: British Journal of Biomedical Science
S-W Ryu, J-H Lee, J Kim, M-A Jang, J-H Nam, M-S Byoun, C S Lim
INTRODUCTION: Influenza rapid diagnostic tests (RDTs) have been developed to supply scientists with more sensitive and specific techniques. Newly developed digital reader-based techniques require test evaluations before their clinical application. METHODS: Two types of digital influenza RDTs using a digital readout system and one conventional RDT were compared using 314 nasopharyngeal swabs of influenza. The swabs originated from symptomatic individuals suspected of influenza infection, and the presence of influenza was confirmed with influenza real-time polymerase chain reaction (PCR) testing and influenza subtyping...
June 21, 2016: British Journal of Biomedical Science
Xiaolan Lin, Jiadi Chen, Huifang Huang
PURPOSE: To assess whether immunostimulatory cytosine-phosphate-guanine oligodeoxynucleotides (CpG-ODN) combined with interleukin-2 (IL-2) improves the number of mitotic metaphases and the detection rate of chromosomal abnormalities in chronic lymphocytic leukaemia (CLL). MATERIALS AND METHODS: Bone marrow specimens were collected from 36 patients with CLL. CLL cells were cultured with CpG-ODN type DSP30 plus IL-2 for 72 h, following which R-banding analysis was conducted...
June 21, 2016: British Journal of Biomedical Science
Melisa Santas-Álvarez, Bruno K Rodiño-Janeiro, Beatriz Paradela-Dobarro, Diego López-Otero, Juan E Viñuela-Roldán, María I Castiñeiras-Landeira, José R González-Juanatey, Ramiro Trillo-Nouche, Ezequiel Álvarez
BACKGROUND: The mobilisation process of endothelial progenitor cells (EPC) after stent implantation by percutaneous coronary intervention (PCI) is unclear because the circulating EPC levels are influenced by several pathophysiological factors. The objective was to analyse the kinetics of EPC concentration following elective PCI in patients with stable angina, and its relation with other biomarkers or parameters of cardiovascular function. METHODS: Pilot study in stable angina patients (n = 30) for elective PCI and implantation of bare-metal stent (BMS), drug-eluting stent (DES) or EPC-capturing stent (ECS)...
June 16, 2016: British Journal of Biomedical Science
Marina Parra, Laura Foj, Xavier Filella
BACKGROUND: Because of its potential value in several pathologies, clinical interest in 25-hydroxy Vitamin D (25OH-D) is increasing. However, the standardisation of assays remains a significant problem. Our aim was to evaluate the performance of the novel Lumipulse G 25-OH Vitamin D assay (Fujirebio), comparing results with the Liaison (Diasorin) method. METHODS: Analytical verification of the Lumipulse G 25-OH Vitamin D assay was performed. Both methods were compared using sera from 226 patients, including 111 patients with chronic renal failure (39 on haemodialysis) and 115 patients without renal failure...
June 16, 2016: British Journal of Biomedical Science
Dina Hassan, Monique Provansal, Sylvain Lehmann, Moustafa Rizk, Pacint Moez, Jerome Vialaret, Christophe Hirtz, Ayman Essa, Hussein Agamia
BACKGROUND: Multiple sclerosis (MS) is a highly heterogeneous disease affecting the central nervous system (CNS). Cerebrospinal fluid (CSF) has been preferred over other body fluids when studying this disease since it is the closest sample related to MS pathological changes. The aim of this study was to investigate differences of CSF protein expression in MS patients by two-dimensional polyacrylamide gel electrophoresis (2-DE) in order to identify candidate biomarkers with potential clinical utility...
June 2, 2016: British Journal of Biomedical Science
K Moolchandani, M Priyadarssini, M Rajappa, S Parameswaran, G Revathy
BACKGROUND: Studies suggest that Chronic Kidney Disease (CKD) is a global burden health associated with significant comorbid conditions. Few biochemical parameters have gained significance in predicting the disease progression. The present work aimed to study the association of the simple biochemical parameter of serum bilirubin level with the estimated glomerular filtration rate (eGFR), and to assess their association with the co-morbid conditions in CKD. METHODS: We recruited 188 patients with CKD who attended a Nephrology out-patient department...
May 27, 2016: British Journal of Biomedical Science
Daria Bortolotti, Claudio Trapella, Tatiana Bernardi, Roberta Rizzo
No abstract text is available yet for this article.
2016: British Journal of Biomedical Science
Elias Khajeh, Seyed Javad Hosseini Shokouh, Masoumeh Rajabibazl, Maryam Roudbary, Sajad Rafiei, Peyman Aslani, Zohreh Farahnejad
BACKGROUND: Several studies examined the effect of the Echinophora platyloba extract in treatment of azole-resistant Candida albicans clinical isolates. OBJECTIVE: We investigated the effect of E. platyloba extract on expression of CDR1 and CDR2 genes in fluconazole-resistant clinical isolates of C. albicans using real-time PCR. MATERIALS AND METHODS: The crude extract of E. platyloba was obtained using percolation method. Using serial dilution method, different concentrations of extract were achieved...
2016: British Journal of Biomedical Science
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