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British Journal of Biomedical Science

Y Dou, L Li, J Du, Y He, R Chen, Y Li, C Ma, H Liu
BACKGROUND: Klebsiella pneumoniae is an opportunistic pathogen, causing an urgent threat to public health because of resistance to the carbapenems. A rapid and accurate molecular method for the detection of K. pneumoniae is required for guiding therapeutic treatment. Therefore, we aimed to develop a multiplex real-time PCR assay for sensitive detection of K. pneumoniae. METHODS: Primers were designed according to the sequences of rcsA and 23S rRNA. Multiplex real-time PCR assay was developed after primers screening and optimization of reaction conditions...
July 11, 2018: British Journal of Biomedical Science
Hatem Elalfy, T Besheer, M A El-Maksoud, K Farid, M Elegezy, A M El Nakib, M A El Aziz, A A El-Khalek, A El-Morsy, A Elmokadem, A Z Elsamanoudy, M A El-Bendary
BACKGROUND: The first-line treatment option for intermediate-stage hepatocellular carcinoma is transarterial chemoembolization. Certain blood indices, such as lymphocyte/monocyte ratio (LMR), lymphocyte count, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte-granulocyte/lymphocyte ratio (MGLR) and red blood cell distribution width (RDW) are prognostic biomarkers in certain diseases. The model for end-stage liver disease (MELD) and Child-Turcotte-Pugh (CTP) scores have been designed for patients with cirrhosis waiting for liver transplantation and in patients with hepatocellular carcinoma...
July 11, 2018: British Journal of Biomedical Science
Sas Girija, V J Priyadharsini, A Paramasivam
No abstract text is available yet for this article.
July 2, 2018: British Journal of Biomedical Science
Mahmoud El-Bendary, Mustafa Neamatallah, Hatem Elalfy, Tarek Besheer, Ayman Elkholy, Muhammad El-Diasty, Maram Elsareef, Magdy Zahran, Bishoy El-Aarag, Asmaa Gomaa, Dina Elhammady, Maged El-Setouhy, Amin Hegazy, Gamal Esmat
BACKGROUND: Single nucleotide polymorphisms (SNPs) of Toll-like receptors (TLRs) have been associated with functional modification or impairment of cytokine responses. In chronic hepatitis C virus (HCV) infection, studies of TLR polymorphisms have primarily targeted receptor pathways implicated in viral immune responses. We hypothesized that one or more variant (s) of TLR3, TLR7 and TLR8 are associated with different outcomes of HCV infection. MATERIALS & METHODS: A total of 3368 subjects from 850 families were recruited and divided into three main groups categorized as chronic HCV (CHCV), spontaneous viral clearance (SVC), and controls...
June 27, 2018: British Journal of Biomedical Science
Nasser Mousa, Ahmed Abdel-Razik, Maher Shams, Tarek Sheta, Sahar Zakaria, Walaa Shabana, Narmin Effat, Muhammad El-Diasty, Sally Abed, Mostafa Abd Elsalam, Mahmoud Awad, Mohamed Salah, Niveen El-Wakeel, Ahmed G Deiab, Waleed Eldars
Introduction&Aims: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease worldwide. This study aims to evaluate the impact of Nonalcoholic fatty liver disease on clinical course and outcome of pregnancy. METHODS: The study included 400 pregnant women free of diabetes prior to pregnancy (Only singleton pregnancy). They were divided into 2 groups; Group 1; included 200 pregnant women with NAFLD and Groups 2; Included 200 pregnant women without NAFLD (control group)...
June 26, 2018: British Journal of Biomedical Science
S M Mirnoori, S S Shahangian, Zivar Salehi, Farhad Mashayeki, S Talesh Sasani, H S Saedi
INTRODUCTION: MicroRNAs (miRNAs) are small ribonucleic acids that modulate the expression of downstream target genes. There is considerable evidence of their involvement in many malignancies, such as oesophageal and gastric. We hypothesised altered expressions of pri-miR-124-1 rs531564 and STAT3 rs1053023 polymorphisms in gastric cancer. MATERIALS AND METHODS: Genomic DNA was extracted from peripheral blood of 250 patients with gastric cancer and 310 healthy individuals...
June 25, 2018: British Journal of Biomedical Science
A M Attallah, D Omran, M S Marie, M A Abdelrazek, A Salama, R El Essawey, L Mobarak, S Maklad, A Omar
BACKGROUND: A single nucleotide polymorphism (SNP) in the interleukin 28B (IL28B) gene may alter the trajectory of hepatitis C virus (HCV) chronic infection. Several studies have sought to determine a link between the IL28B rs12979860 SNP and the development of HCV-related hepatocellular carcinoma (HCC), but with variable results, consensus is awaited. We hypothesised that IL28B rs12979860 SNP is linked to HCC in patients with HCV type 4. METHODS: IL28B genotyping of 300 patients with HCV related fibrosis (n=100), cirrhosis (n=100) and HCC (n=100) was carried out and the results were analyzed to determine the association between the IL28B genotype and clinical outcome...
June 19, 2018: British Journal of Biomedical Science
M Abbas, V S Kushwaha, K Srivastava, S T Raza, M Banerjee
BACKGROUND: Certain forms of chemoradiotherapy generate toxic reactive oxygen species, which may be ameliorated by antioxidant enzymes such as glutathione S-transferase (GST). Genetic polymorphisms of GST may predict treatment outcomes and can be used as genetic marker to screen patients before treatment. We hypothesised an effect of GST polymorphisms on the response and toxicities produced by chemoradiation therapy. MATERIALS AND METHODS: GST polymorphisms were determined by multiplex polymerase chain reaction (mPCR) and PCR-restriction fragment length polymorphism (PCR-RFLP) in 227 women with cervical cancer receiving cisplatin based chemoradiotherapy...
June 18, 2018: British Journal of Biomedical Science
S Rizvi, S T Raza, F Mahdi, S P Singh, M Rajput, Q Rahman
Background Type 2 diabetes mellitus (T2DM) is a global major health problem resulting from interaction of environmental and genetic factors, examples of the latter being KCNJ11 (coding for part of the ATP-sensitive potassium channel) and SDF-1β (coding for chemokine CXCL12). Our case-control study was conducted to assess whether recessive, dominant or additive genotype model associations of KCNJ11 (E23K, rs5219) and SDF-1β (G801A, rs1801157) were more strongly linked to type 2 diabetes. Subjects & Methods Genetic polymorphism analysis was performed by polymerase chain reaction-restriction fragment length polymorphism...
June 12, 2018: British Journal of Biomedical Science
J Lee, M Y Kim, S H Kang, J Kim, Y Uh, K J Yoon, H S Kim
Objective Noninvasive liver fibrosis evaluation is an important issue in chronic hepatitis B infection, and may be assessed using transient elastography (Fibroscan) or with blood markers. We compared the value of Fibroscan with that of a panel of routine serum markers. Materials and methods We recruited 278 chronic hepatitis B patients who underwent Fibroscan and HBV DNA testing. Fibroscan assessments were made, and blood taken for the measurement of the gamma-glutamyl transferase (GGT) to platelet ratio (GPR), platelet count, aspartate aminotransaminase (AST), alanine aminotransaminase (ALT), international normalised ratio (INR), total cholesterol, trigylcerides, bilirubin, mean platelet volume (MPV), AST to platelet ratio index (APRI) and neutrophil to lymphocyte ratio...
June 12, 2018: British Journal of Biomedical Science
A M Attallah, M El-Far, A R Ibrahim, M A El-Desouky, M M Omran, M S Elbendary, K A Attallah, E R Qura, S O Abdallah
BACKGROUND: Although established markers such as CEA and CA19-9 are important for diagnosing early stages of colon cancer, they are not ideal. Developing promising markers include cytokeratin 1 (CK1) and mucin-1 (MUC1), but the combined value of each of these markers is unclear. We therefore evaluated the value of a combined laboratory-based score of these four markers in the diagnosis of colon cancer. METHODS: Two hundred patients who had undergone colonoscopic examination (150 colon cancer, 50 benign growths) were recruited...
May 8, 2018: British Journal of Biomedical Science
R Bhatnager, S Nanda, A S Dang
No abstract text is available yet for this article.
April 18, 2018: British Journal of Biomedical Science
G E Orchard
No abstract text is available yet for this article.
April 18, 2018: British Journal of Biomedical Science
Q Z He, X J Wu, Q Y He, J J Xiang, C H Zhang, L Lu, T Wang, H Li
Background Non-invasive prenatal screening (NIPS) using cell-free foetal DNA (cfDNA) has been widely used for identifying common foetal aneuploidies (e.g. trisomy 21 (T21), trisomy (T18) and trisomy 13 (T13)) in clinical practice. The sensitivity and specificity of NIPS exceeds 99%, but the positive prediction value (PPV) is approximately 70% (combined T21, T18 and T13). Thus, some 30% of pregnant women who have positive NIPS results are eventually identified as normal by amniocentesis. These women therefore must undertake needless invasive tests and risk miscarrying healthy babies because of false positive NIPS results...
July 2018: British Journal of Biomedical Science
S Mashayekhi, H Saeidi Saedi, Z Salehi, S Soltanipour, E Mirzajani
Background microRNAs (miRNAs) are potentially involved in many physiopathological processes, including regulation of cell growth, differentiation, apoptosis and cancer. Single nucleotide polymorphisms of the genes encoding miRNAs can alter their expression and may influence cancer risks. This case-control study explored the relationship between three microRNA polymorphisms (miR-27a, miR-196a2 and miR -146a) and breast cancer (BC). Methods A total of 353 breast cancer cases and 353 controls were genotyped for miR-27a (rs895819), miR-196a2 (rs11614913) and miR -146a (rs2910164)...
April 2018: British Journal of Biomedical Science
Y Liu, X Guo, M Xing, K Zhao, L Luo, J Du
No abstract text is available yet for this article.
April 2018: British Journal of Biomedical Science
S Caskey, J E Moore, J McCaughan, J C Rendall
No abstract text is available yet for this article.
April 2018: British Journal of Biomedical Science
J E Moore, J Hirayama, K Hayashi, C Mason, W Coulter, M Matsuda, C E Goldsmith
No abstract text is available yet for this article.
April 2018: British Journal of Biomedical Science
S Mashayekhi, Z Salehi, A Saberi, M Shakiba, F Mashayekhi, S Yousefzadeh-Chabok
No abstract text is available yet for this article.
April 2018: British Journal of Biomedical Science
K S Amr, H Abdelmawgoud, Z Y Ali, S Shehata, H M Raslan
BACKGROUND: Macrovascular complications are the main cause of morbidity and mortality among the diabetic patients. MicroRNAs (miRNAs), a family of small non-coding RNAs, play vital roles in the regulation of blood glucose level and the concurrent cardiovascular complications of type 2 diabetes. We hypothesized that plasma miR-126 and miR-210 are linked to coronary artery disease (CAD) in these diabetes patients. METHODS: Fasting blood samples were collected from 20 healthy volunteers and 100 patients with diabetes (54 patients without CAD and 46 patients with CAD)...
April 2018: British Journal of Biomedical Science
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