Bin Meng, Jiahui He, Wenbin Cao, Yanru Zhang, Jia Qi, Shiwei Luo, Chong Shen, Juan Zhao, Ying Xue, Pengxiang Qu, Enqi Liu
The global transition towards diets high in calories has contributed to 2.1 billion people becoming overweight, or obese, which damages male reproduction and harms offspring. Recently, more and more studies have shown that paternal exposure to stress closely affects the health of offspring in an intergenerational and transgenerational way. SET Domain Containing 2 ( SETD 2 ), a key epigenetic gene, is highly conserved among species, is a crucial methyltransferase for converting histone 3 lysine 36 dimethylation (H3K36me2) into histone 3 lysine 36 trimethylation (H3K36me3), and plays an important regulator in the response to stress...
November 29, 2023: Zygote: the Biology of Gametes and Early Embryos