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Biological Research

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https://www.readbyqxmd.com/read/30219096/attenuation-of-atherogenic-apo-b-48-dependent-hyperlipidemia-and-high-density-lipoprotein-remodeling-induced-by-vitamin-c-and-e-combination-and-their-beneficial-effect-on-lethal-ischemic-heart-disease-in-mice
#1
S Contreras-Duarte, P Chen, M Andía, S Uribe, P Irarrázaval, S Kopp, S Kern, G Marsche, D Busso, C Wadsack, A Rigotti
BACKGROUND AND AIMS: Atherosclerotic cardiovascular disease is highly prevalent and its underlying pathogenesis involves dyslipidemia including pro-atherogenic high density lipoprotein (HDL) remodeling. Vitamins C and E have been proposed as atheroprotective agents for cardiovascular disease management. However, their effects and benefits on high density lipoprotein function and remodeling are unknown. In this study, we evaluated the role of vitamin C and E on non HDL lipoproteins as well as HDL function and remodeling, along with their effects on inflammation/oxidation biomarkers and atherosclerosis in atherogenic diet-fed SR-B1 KO/ApoER61h/h mice...
September 15, 2018: Biological Research
https://www.readbyqxmd.com/read/30185234/increased-ros-production-and-dna-damage-in-monocytes-are-biomarkers-of-aging-and-atherosclerosis
#2
Thais A Jacinto, Giselle S Meireles, Ananda T Dias, Rafaela Aires, Marcella L Porto, Agata L Gava, Elisardo C Vasquez, Thiago Melo C Pereira, Bianca P Campagnaro, Silvana S Meyrelles
BACKGROUND: New evidence demonstrates that aging and dyslipidemia are closely associated with oxidative stress, DNA damage and apoptosis in some cells and extravascular tissues. However, in monocytes, which are naturally involved in progression and/or resolution of plaque in atherosclerosis, this concurrence has not yet been fully investigated. In this study, we evaluated the influence of aging and hypercholesterolemia on serum pro-inflammatory cytokines, oxidative stress, DNA damage and apoptosis in monocytes from apolipoprotein E-deficient (apoE-/- ) mice compared with age-matched wild-type C57BL/6 (WT) mice...
September 5, 2018: Biological Research
https://www.readbyqxmd.com/read/30180910/mir-214-ameliorates-acute-kidney-injury-via-targeting-dkk3-and-activating-of-wnt-%C3%AE-catenin-signaling-pathway
#3
Xiaoguang Zhu, Wenwen Li, Huicong Li
BACKGROUND: miR-214 was demonstrated to be upregulated in models of renal disease and promoted fibrosis in renal injury independent of TGF-β signaling in vivo. However, the detailed role of miR-214 in acute kidney injury (AKI) and its underlying mechanism are still largely unknown. METHODS: In this study, an I/R-induced rat AKI model and a hypoxia-induced NRK-52E cell model were used to study AKI. The concentrations of kidney injury markers serum creatinine, blood urea nitrogen, and kidney injury molecule-1 were measured...
September 4, 2018: Biological Research
https://www.readbyqxmd.com/read/30180891/knockdown-of-lncrna-mir31hg-inhibits-cell-proliferation-in-human-hacat-keratinocytes
#4
Jintao Gao, Fangru Chen, Mingchun Hua, Junfan Guo, Yuejuan Nong, Qinyan Tang, Fengxia Zhong, Linxiu Qin
BACKGROUND: Psoriasis is a complex, chronic inflammatory skin disease with substantial negative effects on patient quality of life. Long non-coding RNAs (lncRNAs) are able to be involved in multitudes of cellular processes in diverse human diseases. This study aimed to investigate the potential involvement of lncRNA MIR31HG in HaCaT keratinocytes proliferation. RESULTS: The study showed that MIR31HG was significantly elevated in the lesional psoriatic skin compared with normal individuals' skin...
September 4, 2018: Biological Research
https://www.readbyqxmd.com/read/30180883/minimal-residual-disease-in-prostate-cancer-patients-after-primary-treatment-theoretical-considerations-evidence-and-possible-use-in-clinical-management
#5
REVIEW
Nigel P Murray
Minimal residual disease is that not detected by conventional imaging studies and clinically the patient remains disease free. However, with time these dormant cells will awaken and disease progression occurs, resulting in clinically and radiological detectable metastatic disease. This review addresses the concept of tumor cell dissemination from the primary tumor, the micrometastatic niche and tumor cell survival and finally the clinical utility of detecting and characterizing these tumor cells in order to guide management decisions in treating patients with prostate cancer...
September 4, 2018: Biological Research
https://www.readbyqxmd.com/read/30165896/contributions-to-the-bryological-knowledge-of-aspa-125-fildes-peninsula-king-george-island
#6
Diego Knop Henriques, Bárbara Guedes Costa Silva, Gustavo Emílio Zuñiga, Paulo Eduardo Aguiar Saraiva Câmara
BACKGROUND: With 29 Km2 , the Fildes Peninsula is the largest ice free area in King George Island and probably in Antarctica. The region is house of six permanent bases including the only airport in the South Shetlands, which led to impacts on its original landscape and vegetation. In recognition for the need to protect natural values, an Antarctic Specially Protected Area (ASPA 125) was established in the region. Focused mostly on protecting the fossils, the ASPA also plays a role in protecting the vegetation but so far, the management plan for the area does not contain a list of moss species present there...
August 30, 2018: Biological Research
https://www.readbyqxmd.com/read/30149803/cold-active-pectinolytic-activity-produced-by-filamentous-fungi-associated-with-antarctic-marine-sponges
#7
Gabriela Poveda, Carlos Gil-Durán, Inmaculada Vaca, Gloria Levicán, Renato Chávez
BACKGROUND: Pectinase enzymes catalyze the breakdown of pectin, a key component of the plant cell wall. At industrial level, pectinases are used in diverse applications, especially in food-processing industry. Currently, most of the industrial pectinases have optimal activity at mesophilic temperatures. On the contrary, very little is known about the pectinolytic activities from organisms from cold climates such as Antarctica. In this work, 27 filamentous fungi isolated from marine sponges collected in King George Island, Antarctica, were screened as new source of cold-active pectinases...
August 27, 2018: Biological Research
https://www.readbyqxmd.com/read/30124166/bioinformatics-analysis-of-microarray-data-to-reveal-the-pathogenesis-of-diffuse-intrinsic-pontine-glioma
#8
Li Wei, Fei He, Wen Zhang, Wenhua Chen, Bo Yu
BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is the main cause of pediatric brain tumor death. This study was designed to identify key genes associated with DIPG. METHODS: The gene expression profile GSE50021, which consisted of 35 pediatric DIPG samples and 10 normal brain samples, was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were identified by limma package. Functional and pathway enrichment analyses were performed by the DAVID tool...
August 20, 2018: Biological Research
https://www.readbyqxmd.com/read/30124164/missing-and-overexpressing-proteins-in-domestic-cat-oocytes-following-vitrification-and-in-vitro-maturation-as-revealed-by-proteomic-analysis
#9
Bongkoch Turathum, Sittiruk Roytrakul, Chinarat Changsangfa, Morakot Sroyraya, Supita Tanasawet, Yindee Kitiyanant, Kulnasan Saikhun
BACKGROUND: The domestic cat serves as an animal model for assisted reproductive studies of endangered felid species. To date, there are no data on the protein alterations following cryopreservation of oocytes in felid family. METHODS: Immature (germinal vesicle) domestic cat oocytes were vitrified in the vitrification solution containing 35% ethylene glycol, 20% DMSO and 0.5 mM sucrose. The vitrified-warmed oocytes were matured (metaphase II) in vitro and subjected to proteomic analysis using 1DE SDS-PAGE prefractionation combined with LC-MS/MS...
August 20, 2018: Biological Research
https://www.readbyqxmd.com/read/30119702/identification-of-key-genes-and-pathways-involved-in-response-to-pain-in-goat-and-sheep-by-transcriptome-sequencing
#10
Xiuling Deng, Dong Wang, Shenyuan Wang, Haisheng Wang, Huanmin Zhou
PURPOSE: This aim of this study was to investigate the key genes and pathways involved in the response to pain in goat and sheep by transcriptome sequencing. METHODS: Chronic pain was induced with the injection of the complete Freund's adjuvant (CFA) in sheep and goats. The animals were divided into four groups: CFA-treated sheep, control sheep, CFA-treated goat, and control goat groups (n = 3 in each group). The dorsal root ganglions of these animals were isolated and used for the construction of a cDNA library and transcriptome sequencing...
August 17, 2018: Biological Research
https://www.readbyqxmd.com/read/30097015/knockdown-of-paics-inhibits-malignant-proliferation-of-human-breast-cancer-cell-lines
#11
Minjun Meng, Yanling Chen, Jianbo Jia, Lianghui Li, Sumei Yang
BACKGROUND: Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), an enzyme required for de novo purine biosynthesis, is associated with and involved in tumorigenesis. This study aimed to evaluate the role of PAICS in human breast cancer, which remains the most frequently diagnosed cancer and the leading cause of cancer-related death among women in less developed countries. RESULTS: Lentivirus-based short hairpin RNA targeting PAICS specifically depleted its endogenous expression in ZR-75-30 and MDA-MB-231 breast cancer cells...
August 10, 2018: Biological Research
https://www.readbyqxmd.com/read/30086794/a-nexus-model-of-cellular-transition-in-cancer
#12
REVIEW
Mukesh Yadav, Payal Chatterjee, Simran Tolani, Jaya Kulkarni, Meenakshi Mulye, Namrata Chauhan, Aditi Sakhi, Sakshi Gorey
The exact cause of cancer is one of the most immutable medical questions of the century. Cancer as an evolutionary disease must have a purpose and understanding the purpose is more important than decoding the cause. The model of cancer proposed herein, provides a link between the cellular biochemistry and cellular genetics of cancer evolution. We thus call this model as the "Nexus model" of cancer. The Nexus model is an effort to identify the most apparent route to the disease. We have tried to utilize existing cancer literature to identify the most plausible causes of cellular transition in cancer, where the primary cancer-causing agents (physical, chemical or biological) act as inducing factors to produce cellular impeders...
August 7, 2018: Biological Research
https://www.readbyqxmd.com/read/30012208/protective-roles-of-autophagy-in-retinal-pigment-epithelium-under-high-glucose-condition-via-regulating-pink1-parkin-pathway-and-bnip3l
#13
Chengchi Huang, Hong Lu, Junyu Xu, Hongmin Yu, Xiaodan Wang, Xiaomei Zhang
BACKGROUND: Our study aimed to investigate the roles of autophagy against high glucose induced response in retinal pigment epithelium (ARPE-19 cells). METHODS: The morphological changes and reactive oxygen species (ROS) generation in ARPE-19 cells under high glucose treatment were respectively detected using the transmission electron microscopy and flow cytometry. The expression levels of Parkin, PINK1, BNIP3L, LC3-I and LC3-II in ARPE-19 cells received high glucose treatment were measured by western blot after pretreatment of carbonyl cyanide m-chlorophenylhydrazone (CCCP), 3-methyladenine (3-MA), N-acetyl cysteine (NAC) or cyclosporin A (CsA) followed by high glucose treatment...
July 16, 2018: Biological Research
https://www.readbyqxmd.com/read/29980225/electroacupuncture-ameliorate-learning-and-memory-by-improving-n-acetylaspartate-and-glutamate-metabolism-in-app-ps1-mice
#14
Ruhui Lin, Long Li, Yingzheng Zhang, Sheng Huang, Shangjie Chen, Jiao Shi, Peiyuan Zhuo, Hao Jin, Zuanfang Li, Weilin Liu, Zhifu Wang, Lidian Chen, Jing Tao
OBJECTIVE: To explore the precise mechanism of electroacupuncture (EA) to delay cognitive impairment in Alzheimer disease. METHODS: N-Acetylaspartate (NAA), glutamate (Glu) and myoinositol (mI) metabolism were measured by magnetic resonance spectroscopy, learning and memory of APP/PS1 mouse was evaluated by the Morris water maze test and the step-down avoidance test, neuron survival number and neuronal structure in the hippocampus were observed by Nissl staining, and BDNF and phosphorylated TrkB detected by Western blot...
July 6, 2018: Biological Research
https://www.readbyqxmd.com/read/29933757/expression-of-concern-to-knockdown-of-zfr-suppresses-cell-proliferation-and-invasion-of-human-pancreatic-cancer
#15
Xiaolan Zhao, Man Chen, Jishan Tan
Concerns have been raised about this article [1] relating to the appropriateness of the use of the shRNA (5'-GCGGAGGGTTTGAAAGAATATCTCGAGATATTCTTTCAAACCCTCCGCTTTTTT-3') as a non-targeting control and similarities in text and formatting with other published articles. This is currently under investigation and appropriate editorial action will be taken once the investigation is concluded. The authors did not respond to our correspondence regarding this expression of concern.
June 22, 2018: Biological Research
https://www.readbyqxmd.com/read/29933754/expression-of-concern-to-lentivirus-mediated-silencing-of-ubiquitin-specific-peptidase-39-inhibits-cell-proliferation-of-human-hepatocellular-carcinoma-cells-in-vitro
#16
Zeya Pan, Hao Pan, Jin Zhang, Yun Yang, Hui Liu, Yuan Yang, Gang Huang, Junsheng Ni, Jian Huang, Weiping Zhou
Concerns have been raised about this article [1] relating to the appropriateness of the use of the shRNA (5'-GCGGAGGGTTTGAAAGAATATCTCGAGATATTCTTTCAAACCCTCCGCTTTTTT-3') as a non-targeting control and similarities in text and formatting with other published articles. This is currently under investigation and appropriate editorial action will be taken once the investigation is concluded. The authors agree.
June 22, 2018: Biological Research
https://www.readbyqxmd.com/read/29898774/arsenic-trioxide-induces-cell-cycle-arrest-and-affects-trk-receptor-expression-in-human-neuroblastoma-sk-n-sh-cells
#17
Xilin Xiong, Yang Li, Ling Liu, Kai Qi, Chi Zhang, Yueqin Chen, Jianpei Fang
BACKGROUND: Arsenic trioxide (As2 O3 ), a drug that has been used in China for approximately two thousand years, induces cell death in a variety of cancer cell types, including neuroblastoma (NB). The tyrosine kinase receptor (Trk) family comprises three members, namely TrkA, TrkB and TrkC. Various studies have confirmed that TrkA and TrkC expression is associated with a good prognosis in NB, while TrkB overexpression can lead to tumor cell growth and invasive metastasis. Previous studies have shown that As2 O3 can inhibit the growth and proliferation of a human NB cell line and can also affect the N-Myc mRNA expression...
June 13, 2018: Biological Research
https://www.readbyqxmd.com/read/29891016/melatonin-ameliorates-h-2-o-2-induced-oxidative-stress-through-modulation-of-erk-akt-nfkb-pathway
#18
Mahammed Moniruzzaman, Indranath Ghosal, Debjit Das, Suman Bhusan Chakraborty
BACKGROUND: Improper control on reactive oxygen species (ROS) elimination process and formation of free radicals causes tissue dysfunction. Pineal hormone melatonin is considered a potent regulator of such oxidative damage in different vertebrates. Aim of the current communication is to evaluate the levels of oxidative stress and ROS induced damage, and amelioration of oxidative status through melatonin induced activation of signaling pathways. Hepatocytes were isolated from adult Labeo rohita and exposed to H2 O2 at three different doses (12...
June 11, 2018: Biological Research
https://www.readbyqxmd.com/read/29880026/the-effect-of-downregulation-of-stathmin-gene-on-biological-behaviors-of-u373-and-u87-mg-glioblastoma-cells
#19
Ping Liu, Junyan Yu, Xiangyang Tian, Jianlan Chang, Ying Zhang, Rong Zhang, Ningning Zhang, Ranxing Huang, Lulu Li, Xianli Qiao, Hongliang Guo
BACKGROUND: Stathmin as a critical protein involved in microtubule polymerization, is necessary for survival of cancer cells. However, extremely little is known about Stathmin in glioblastoma. So, this study was designed to elucidate the function of Stathmin gene in the tumorigenesis and progression of glioblastoma cells. METHOD: The lentiviral interference vector pLV3-si-Stathmin targeting Stathmin gene and the control vector pLV3-NC were established for the co-transfection of 293T cells together with the helper plasmids...
June 8, 2018: Biological Research
https://www.readbyqxmd.com/read/29866159/extracellular-matrix-and-fibroblast-injection-produces-pterygium-like-lesion-in-rabbits
#20
Judith Zavala, Julio C Hernandez-Camarena, Brenda Salvador-Gálvez, José E Pérez-Saucedo, Amin Vela-Martinez, Jorge E Valdez-García
BACKGROUND: Translational research to develop pharmaceutical and surgical treatments for pterygium requires a reliable and easy to produce animal model. Extracellular matrix and fibroblast are important components of pterygium. The aim of this study was to analyze the effect of the subconjunctival injection of fibroblast cells (NIH3T3 cell line) and exogenous extracellular matrix in rabbits in producing a pterygium-like lesion. METHODS: Six 3-month-old white New Zealand rabbits were injected with 20,000 NIH3T3 cells and 5 µL of Matrigel in the right conjunctiva, and with only 5 µL of Matrigel in the left conjunctiva...
June 5, 2018: Biological Research
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