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Hypertension Research: Official Journal of the Japanese Society of Hypertension

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https://www.readbyqxmd.com/read/29985448/simultaneous-glp-1-receptor-activation-and-angiotensin-receptor-blockade-increase-natriuresis-independent-of-altered-arterial-pressure-in-obese-oletf-rats
#1
Ruben Rodriguez, Meagan Moreno, Andrew Y Lee, Jose A Godoy-Lugo, Daisuke Nakano, Akira Nishiyama, David Parkes, Mouhamed S Awayda, Rudy M Ortiz
Obesity is associated with an inappropriately activated renin-angiotensin-aldosterone system, suppressed glucagon-like peptide-1 (GLP-1), increased renal Na+ reabsorption, and hypertension. To assess the link between GLP-1 and angiotensin receptor type 1 (AT1 ) signaling on obesity-associated impairment of urinary Na+ excretion (UNa V) and elevated arterial pressure, we measured mean arterial pressure (MAP) and heart rate by radiotelemetry and metabolic parameters for 40 days. We tested the hypothesis that stimulation of GLP-1 signaling provides added benefit to blockade of AT1 by increasing UNa V and further reducing arterial pressure in the following groups: (1) untreated Long-Evans Tokushima Otsuka (LETO) rats (n = 7); (2) untreated Otsuka Long-Evans Tokushima Fatty (OLETF) rats (n = 9); (3) OLETF + ARB (ARB; 10 mg olmesartan/kg/day; n = 9); (4) OLETF + GLP-1 receptor agonist (EXE; 10 µg exenatide/kg/day; n = 7); and (5) OLETF + ARB + EXE (Combo; n = 6)...
July 9, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29977083/optimal-schedule-of-home-blood-pressure-measurements-for-the-diagnosis-of-hypertension
#2
Moo-Yong Rhee, Jang Young Kim, Ji-Hyun Kim, June Namgung, Sung Yun Lee, Deok-Kyu Cho, Tae-Young Choi, Seok Yeon Kim
Various home blood-pressure (HBP) measurement schedules were compared to determine the optimal schedule of HBP measurement for the diagnosis of hypertension. Out of 319 individuals who were suspected of having hypertension based on office BP measurements and who did not take antihypertensive drugs, 157 individuals who completed 42 HBP measurements over 7 days and who had a valid 24-h ambulatory blood pressure (ABP) measurement were included in this analysis. We evaluated five HBP measurement schedules to determine the optimal HBP measurement schedule for the diagnosis of hypertension...
July 5, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29973661/microrna-21-and-hypertension
#3
REVIEW
Xiao Li, Yongxiang Wei, Zuoguang Wang
Hypertension, a multifactorial disease, is a major risk factor for the development of stroke, coronary artery disease, heart failure, and chronic renal failure. However, its underlying cellular and molecular mechanisms remain largely elusive. Numerous studies have shown that microRNAs (miRNAs) are involved in a variety of cellular processes, including cellular proliferation, apoptosis, differentiation, and the development of diseases. microRNA-21 (miR-21), a conserved single-stranded non-coding RNA that is composed of approximately 22 nucleotides, is one of the most intensively studied miRNAs in recent years, and it can regulate gene expression at the post-transcriptional level...
July 4, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29968848/healthy-aging-and-carotid-performance-strain-measures-and-%C3%AE-stiffness-index
#4
Alexander J Rosenberg, Abbi D Lane-Cordova, Sang Ouk Wee, Daniel W White, Thessa I M Hilgenkamp, Bo Fernhall, Tracy Baynard
Arterial stiffness is related to the risk of cardiovascular disease (CVD) and increases with aging. Functional impairment of the arterial wall can occur before structural changes and can be detectable before CVD symptoms. The elastic properties of the carotid arterial wall during the cardiac cycle can be evaluated by standard 2-dimensional (2D) ultrasound longitudinal or circumferential imaging of vascular deformation (strain) using speckle tracking. The purpose of this study was to compare standard 2D ultrasound circumferential and longitudinal images of vascular tissue motion and strain using speckle tracking in young and older individuals...
July 3, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29968847/renal-artery-fibromuscular-dysplasia-and-its-effect-on-the-kidney
#5
REVIEW
Daan J L van Twist, Peter W de Leeuw, Abraham A Kroon
Fibromuscular dysplasia is a heterogeneous group of systemic, noninflammatory, and nonatherosclerotic diseases of the vascular wall. It is the second-most common abnormality of the renal artery. Although hypertension is the most common presenting symptom, other symptoms, such as pulsatile tinnitus, stroke, chest pain, or abdominal discomfort, may result from other affected vascular beds. Revascularization of the renal artery appears to be effective at lowering blood pressure in many patients with renal artery fibromuscular dysplasia...
July 3, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29967417/aerobic-exercise-enhanced-endothelium-dependent-vasorelaxation-in-mesenteric-arteries-in-spontaneously-hypertensive-rats-the-role-of-melatonin
#6
Fang Qiu, Xiaodong Liu, Yanyan Zhang, Ying Wu, Daliao Xiao, Lijun Shi
Melatonin, a neuroendocrine hormone synthesized primarily by the pineal gland, provides various cardiovascular benefits. Regular physical activity is an effective non-pharmacological therapy for the prevention and control of hypertension. In the present study, we hypothesized that melatonin plays an important role in the aerobic exercise-induced increase of endothelium-dependent vasorelaxation in the mesenteric arteries (MAs) of spontaneously hypertensive rats (SHRs) in a melatonergic receptor-dependent manner...
July 2, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29950684/setd3-negatively-regulates-vegf-expression-during-hypoxic-pulmonary-hypertension-in-rats
#7
Xiufeng Jiang, Tianxiang Li, Jia Sun, Jing Liu, Hui Wu
Angiogenesis and activation of vascular endothelial growth factor (VEGF) signaling are tightly regulated under the condition of hypoxic pulmonary hypertension (HPH); therefore, deciphering the regulatory mechanisms associated with VEGF is important. SET domain-containing 3 (SETD3) and VEGF expression in lung tissue during hypoxia exposure and lentivirus. SETD3 treatments were detected by real-time PCR and Western blot analysis. Remodeling of pulmonary vasculature and hypertrophy of the RV were evaluated. The effects of SETD3 over-expression on the interaction between SETD3 and forkhead box protein M1 (FoxM1) at the VEGF promoter and downstream of the VEGF signal pathway during chronic hypoxia were detected...
June 27, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29950683/reduced-secretion-of-parathyroid-hormone-and-hypocalcemia-in-systemic-heterozygous-atp2b1-null-hypertensive-mice
#8
Yosuke Ehara, Nobuhito Hirawa, Kouichiro Sumida, Akira Fujiwara, Minako Kagimoto, Yuki Ooki-Okuyama, Megumi Fujita, Mari Katsumata, Yusuke Kobayashi, Sanae Saka, Ikuma Katou, Keisuke Yatsu, Satoshi Umemura, Kouichi Tamura
The ATP2B1 gene is associated with hypertension. We previously reported that systemic heterozygous ATP2B1-null (ATP2B1+/- ) mice exhibited hypertension due to impaired endothelial nitric oxide synthase (eNOS) activity and decreased nitric oxide (NO) production. The ATP2B1 gene encodes plasma membrane calcium ATPase 1 (PMCA1), which has been thought to regulate only intracellular Ca2+ concentration. However, recently, it has been suggested that ATP2B1 works not only at cellular levels, but also throughout the entire body, including in the calcium metabolism, using small intestine-specific ATP2B1 knockout mice...
June 27, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29946156/increased-plasma-fatty-acid-binding-protein-4-concentration-at-the-first-prenatal-visit-and-its-relevance-to-preeclampsia
#9
Gai-Hong Qiao, Xiao-Zhen Sun
Preeclampsia affects 2-8% of all pregnancies, and it is associated with significant perinatal mortality and morbidities including preterm birth and small for gestational age. We examined whether plasma fatty acid binding protein 4 (FABP4) concentrations are associated with risk of later preeclampsia development. From March 2015 to May 2016, serum FABP4 was measured in 1486 women in early pregnancy. The relationship between the levels of FABP4 and preeclampsia were evaluated using univariate and multivariate regression analysis...
June 26, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29925901/gitelman-s-syndrome-characterization-of-a-novel-c-1181g-a-point-mutation-and-functional-classification-of-the-known-mutations
#10
Verdiana Ravarotto, Johannes Loffing, Dominique Loffing-Cueni, Michèle Heidemeyer, Elisa Pagnin, Lorenzo A Calò, Gian Paolo Rossi
We have investigated the mechanisms by which a novel missense point mutation (c.1181G>A) found in two sisters causes Gitelman's syndrome by impairing the sodium chloride co-transporter (NCC, encoded by SLC12A3 gene) function. The cDNA and in vitro transcribed mRNA of either wild-type or mutated SLC12A3 were transfected into HEK293 cells and injected into Xenopus laevis oocytes, respectively. The expression, maturation, trafficking, and function of the mutated and wild-type NCC were assessed by Western blotting, immunohistochemistry and 22 Na+ uptake studies...
June 20, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29907861/higher-plasma-leptin-levels-are-associated-with-reduced-left-ventricular-mass-and-left-ventricular-diastolic-stiffness-in-black-women-insights-from-the-genetic-epidemiology-network-of-arteriopathy-genoa-study
#11
Daisuke Kamimura, Takeki Suzuki, Wanmei Wang, Matthew deShazo, John E Hall, Michael D Winniford, Iftikhar J Kullo, Thomas H Mosley, Kenneth R Butler, Michael E Hall
Our previous experimental animal data suggest a beneficial effect of leptin on LV structure and function. We hypothesized that leptin levels are associated with lower LV mass and myocardial stiffness which are important risk factors for the development of heart failure with preserved ejection fraction (HFpEF). We evaluated 1172 blacks, in which the prevalence of HFpEF is quite high, with preserved LV ejection fraction (EF > 50%) from the Genetic Epidemiology Network of Arteriopathy Study (mean age 62...
June 15, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29899365/greater-nighttime-blood-pressure-variability-is-associated-with-left-atrial-enlargement-in-atrial-fibrillation-patients-with-preserved-ejection-fraction
#12
Naoki Norioka, Shinichi Iwata, Asahiro Ito, Soichiro Tamura, Yu Kawai, Shinichi Nonin, Sera Ishikawa, Atsushi Doi, Akihisa Hanatani, Minoru Yoshiyama
Left atrial enlargement is an independent risk factor for ischemic stroke in patients with atrial fibrillation. Little is known regarding the association between nighttime blood pressure variability and left atrial enlargement in patients with atrial fibrillation and preserved ejection fraction. The study population consisted of 140 consecutive patients with atrial fibrillation (mean age 64 ± 10 years) with preserved ejection fraction (≥50%). Nighttime blood pressure was measured at hourly intervals, using a home blood pressure monitoring device...
June 13, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29895822/role-of-activating-transcription-factor-3-in-fructose-induced-metabolic-syndrome-in-mice
#13
Chu-Lin Chou, Ching-Hao Li, Heng Lin, Mei-Hui Liao, Chin-Chen Wu, Jin-Shuen Chen, Yuh-Mou Sue, Te-Chao Fang
Activating transcription factor 3 (ATF3) has been implicated in cardiovascular disease and inflammation. This study examined the effects of ATF3 knockout (KO) on blood pressure, glucose intolerance, dyslipidemia, inflammation, and visceral adiposity in mice fed who did and did not consume a high-fructose diet. Male mice were divided into four groups (N = 15 for each group): the Con (control) group (wild-type mice fed a standard chow diet), Fru group (wild-type mice fed a high-fructose [60% fructose] diet), ATF3KO-Con group (ATF3 KO mice fed a standard chow diet), and ATF3KO-Fru group (ATF3 KO mice fed a high-fructose [60% fructose] diet)...
June 12, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29895821/comment-on-body-mass-index-and-contralateral-ratio-predict-outcome-following-unilateral-adrenalectomy-in-primary-aldosteronism
#14
EDITORIAL
Jie Weng, He Wu, Zhiyi Wang
No abstract text is available yet for this article.
June 12, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29880838/association-of-mitofusin-2-methylation-and-essential-hypertension-a-case-control-study-in-a-chinese-population
#15
Fei Jin, Xiao Li, Zuoguang Wang, Ya Liu, Jielin Liu, Dongdong Sun, Yongxin Jin, Shiqi Wang, Shaojun Wen, Yongxiang Wei
Mitofusin 2 (Mfn2), a gene that negatively regulates the proliferation of vascular smooth muscle cells (VSMCs), is expressed at low levels in the VSMCs of hypertensive patients. DNA methylation can inhibit gene expression. The purpose of this study was to investigate the relationship between Mfn2 methylation and essential hypertension (EH). After bioinformatics analysis, five EH patients and five normal control (NC) subjects were selected for methylation chip screening. Then, bisulfite DNA sequencing was used to analyze the methylation status of differentially methylated fragments of Mfn2 in 40 EH patients and 36 NC subjects...
June 7, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29880837/baroreflex-failure-and-beat-to-beat-blood-pressure-variation
#16
REVIEW
Takuya Kishi
Hypertension has strong adverse effects on cardiovascular diseases, and increased blood pressure (BP) variability (BPV) is closely associated with the development of hypertensive organ injuries and the occurrence of cardiovascular diseases. Similar to other forms of BPV, short-term beat-to-beat BPV has also been established as a risk factor for cardiovascular diseases. Baroreflex failure is the major mechanism involved in the pathophysiology of short-term beat-to-beat BPV. Previous clinical and animal studies have demonstrated that baroreflex failure disrupted beat-to-beat BPV and hypertensive organ damage...
June 7, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29849165/central-hemodynamics-and-left-ventricular-hypertrophy-in-chronic-kidney-disease
#17
EDITORIAL
Naoki Nakagawa, Naoyuki Hasebe
No abstract text is available yet for this article.
May 30, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29808034/clinical-significance-of-stress-related-increase-in-blood-pressure-current-evidence-in-office-and-out-of-office-settings
#18
REVIEW
Masanori Munakata
High blood pressure is the most significant risk factor of cardiovascular and cerebrovascular diseases worldwide. Blood pressure and its variability are recognized as risk factors. Thus, hypertension control should focus not only on maintaining optimal levels but also on achieving less variability in blood pressure. Psychosocial stress is known to contribute to the development and worsening of hypertension. Stress is perceived by the brain and induces neuroendocrine responses in either a rapid or long-term manner...
May 29, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29808033/predictive-power-of-home-blood-pressure-indices-at-baseline-and-during-follow-up-in-hypertensive-patients-homed-bp-study
#19
Daisuke Watabe, Kei Asayama, Tomohiro Hanazawa, Miki Hosaka, Michihiro Satoh, Daisaku Yasui, Taku Obara, Ryusuke Inoue, Hirohito Metoki, Masahiro Kikuya, Yutaka Imai, Takayoshi Ohkubo
We compared the predictive power for a major adverse cardiovascular event (MACE) of four home blood pressure (BP) indices (systolic BP, diastolic BP, mean BP, and pulse pressure (PP)) obtained at baseline before treatment and during the on-treatment follow-up period in 3147 patients with essential hypertension (women: 50.1%, mean age: 59.5 years). Associations between MACE and each index were determined using Cox proportional hazard models and the likelihood ratio (LR) test. During a median follow-up of 5.4 years, 46 patients experienced MACE, which was a composite of cardiovascular death, non-fatal stroke, and non-fatal myocardial infarction...
May 29, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29808032/neuroimaging-findings-in-women-who-develop-neurologic-symptoms-in-severe-preeclampsia-with-or-without-eclampsia
#20
Xiaodan Di, Hui Mai, Zheng Zheng, Kaimin Guo, Abraham N Morse, Huishu Liu
Eclampsia is a leading cause of maternal and fetal morbidity and mortality worldwide, and its pathogenesis remains elusive. Our objective was to investigate neuroimaging findings in women who developed neurologic symptoms in severe preeclampsia with or without eclampsia to further understand the relationship between neuroimaging findings and the pathogenesis of eclamptic seizures. This retrospective study included 79 women with severe preeclampsia/eclampsia who underwent brain MRI/CT examination between 2005 and 2017...
May 29, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
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