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Hypertension Research: Official Journal of the Japanese Society of Hypertension

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https://www.readbyqxmd.com/read/29765140/comment-on-resistance-training-alone-reduces-systolic-and-diastolic-blood-pressure-in-prehypertensive-and-hypertensive-individuals-meta-analysis
#1
EDITORIAL
Salman Khazaei, Manoochehr Karami, Yousef Veisani
No abstract text is available yet for this article.
May 15, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29760461/arterial-stiffness-not-systolic-blood-pressure-increases-with-age-in-native-papuan-populations
#2
Akio Ishida, Michiko Fujisawa, Eva Garcia Del Saz, Kiyohito Okumiya, Yumi Kimura, Indrajaya Ida Bagus Manuaba, Marthen Ferry Kareth, Andreas Lallo Rantetampang, Yusuke Ohya, Kozo Matsubayashi
Systolic blood pressure (SBP) and arterial stiffness are closely related and may behave reciprocally as cause or effect, interacting in a vicious cycle. Both SBP and arterial stiffness increase with age in populations in most developed countries. However, the age-related increase in SBP appears to be absent in indigenous populations, partially because of their lifelong low-sodium and high-potassium diets, whereas age-related arterial stiffening in these populations remains to be determined. We performed a field survey of the indigenous population of Soroba, a small village located in the central highlands of Papua, Indonesia...
May 14, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29760460/seasonal-blood-pressure-variation-implications-for-cardiovascular-risk-stratification
#3
REVIEW
Pietro Amedeo Modesti, Stefano Rapi, Angela Rogolino, Benedetta Tosi, Giorgio Galanti
Long-term blood pressure variations contribute to an increased risk of cardiovascular events during cold season, requiring personalized management of antihypertensive medications in a single patient, and can influence the results of clinical trials and epidemiological surveys in population studies. In addition to blood pressure values, which guide the stratification of cardiovascular risk, other cardiovascular risk factor levels also tend to be higher in the winter months and lower in the summer months. The resultant estimation of individual cardiovascular risk may thus vary depending on the season...
May 14, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29748580/modulation-of-sympathetic-preganglionic-neuron-activity-via-adrenergic-receptors
#4
Yoshino Minoura, Hiroshi Onimaru, Kamon Iigaya, Youichi Kobayashi
The sympathetic preganglionic neurons (SPNs) play a key role in the sympathetic nervous system. Previous reports have suggested that norepinephrine (NE) directly affects SPNs via both inhibitory hyperpolarization interactions mediated by α2 receptors and excitatory depolarization interactions mediated by α1 receptors. It remains poorly understood, however, whether the excitability of SPNs can be inhibited indirectly (presynaptically) as well as directly (postsynaptically). We intracellularly recorded 41 SPNs using the whole-cell patch-clamp technique in spinal cord slice preparations of neonatal rats...
May 10, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29720675/can-we-accurately-measure-the-ankle-brachial-index-in-patients-with-atrial-fibrillation
#5
EDITORIAL
Victor Aboyans, Ileana Desormais
No abstract text is available yet for this article.
May 2, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29695773/stromal-interaction-molecule-1-modulates-blood-pressure-via-no-production-in-vascular-endothelial-cells
#6
Mitsuhiro Nishimoto, Risuke Mizuno, Toshiro Fujita, Masashi Isshiki
In vascular endothelial cells, store-operated calcium entry (SOCE) activates endothelial NO synthase (eNOS) and regulates nitric oxide (NO) production as well as flow-dependent mechanical stimuli. Stromal interaction molecule 1, or STIM1, was recently identified to be essential for SOCE, acting as a calcium sensor for intracellular calcium stores. However, how STIM1 affects endothelial function and blood pressure (BP) remains unclear. We generated STIM1 fl/fl mice and vascular endothelial cell-specific STIM1 knockout mice using the Cre-loxP system, and conducted experiments using these mice to clarify the physiological role of STIM1 in vascular endothelial function and BP as follows: (1) SOCE was analyzed in isolated aortic endothelial cells by calcium add-back with fluorescent Ca2+ indicators...
April 25, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29695772/effects-of-self-monitoring-of-daily-salt-intake-estimated-by-a-simple-electrical-device-for-salt-reduction-a-cluster-randomized-trial
#7
Toshihiko Takada, Miyuki Imamoto, Sho Sasaki, Teruhisa Azuma, Jun Miyashita, Michio Hayashi, Shingo Fukuma, Shunichi Fukuhara
Recently, a simple device for self-monitoring of daily salt intake was developed, and it is recommended by The Japanese Society of Hypertension. This study aimed to investigate the effects of this device on salt reduction and on lowering blood pressure. In this single blinded, cluster randomized controlled trial, families were randomly assigned to either an intervention or a control group. Participants in both groups attended lectures about salt reduction, but only the intervention group used the self-monitoring device to estimate their daily salt intake...
April 25, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29686318/microcirculation-and-biomarkers-in-patients-with-resistant-or-mild-to-moderate-hypertension-a-cross-sectional-study
#8
Camillo L C Junqueira, Maria Eliane C Magalhães, Andréa Araújo Brandão, Esmeralci Ferreira, Fátima Z G A Cyrino, Priscila A Maranhão, Maria das Graças C Souza, Daniel Alexandre Bottino, Eliete Bouskela
Microcirculation influences peripheral vascular resistance and therefore contributes to arterial blood pressure. The aim of this study was to investigate the correlation between serum markers of inflammation and microcirculatory parameters observed by nailfold videocapillaroscopy (NVC) in patients with resistant (RH, 58 [50-63] years, n = 25) or mild-to-moderate hypertension (MMH, 56 [47-64] years, n = 25) compared to normotensive patients (control group (CG), 33 [27-52] years, n = 25). C-reactive protein (CRP), endothelin, adiponectin, I-CAM and V-CAM levels were obtained by laboratory analysis...
April 23, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29670254/white-coat-hypertension-and-albuminuria-lessons-from-the-hisayama-and-ohasama-studies
#9
EDITORIAL
Yasuyuki Nagasawa, Aritoshi Kida, Yukiko Hasuike, Takahiro Kuragano, Takeshi Nakanishi
No abstract text is available yet for this article.
April 18, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29654296/burden-of-high-blood-pressure-as-a-contributing-factor-to-stroke-in-the-japanese-community-based-diabetic-population
#10
Ryosuke Komi, Fumitaka Tanaka, Shinichi Omama, Yasuhiro Ishibashi, Kozo Tanno, Toshiyuki Onoda, Masaki Ohsawa, Kentaro Tanaka, Akira Okayama, Motoyuki Nakamura
Diabetes mellitus is characterized by alterations in blood glucose (BG) metabolism, and glycated hemoglobin (HbA1 c) has been widely used as a marker of the BG concentration. Diabetes often coexists with high blood pressure (BP). High BP and hyperglycemia are well-known risk factors of stroke. We examined the extent to which the increased risk of stroke in diabetic individuals is attributable to BP and BG using prospectively collected data from the Japanese general population. During an average 8.3 ± 2...
April 13, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29654295/antihypertensive-effect-of-etamicastat-in-dopamine-d2-receptor-deficient-mice
#11
Ines Armando, Laureano D Asico, Xiaoyan Wang, John E Jones, Maria Paula Serrão, Santiago Cuevas, David K Grandy, Patricio Soares-da-Silva, Pedro A Jose
Abnormalities of the D2 R gene (DRD2) play a role in the pathogenesis of human essential hypertension; variants of the DRD2 have been reported to be associated with hypertension. Disruption of Drd2 (D2 -/- ) in mice increases blood pressure. The hypertension of D2 -/- mice has been related, in part, to increased sympathetic activity, renal oxidative stress, and renal endothelin B receptor (ETBR) expression. We tested in D2 -/- mice the effect of etamicastat, a reversible peripheral inhibitor of dopamine-β-hydroxylase that reduces the biosynthesis of norepinephrine from dopamine and decreases sympathetic nerve activity...
April 13, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29636553/the-role-of-the-angiotensin-ii-type-i-receptor-blocker-telmisartan-in-the-treatment-of-non-alcoholic-fatty-liver-disease-a-brief-review
#12
REVIEW
Luciana M A Borém, João F R Neto, Igor V Brandi, Deborah F Lelis, Sergio H S Santos
Non-alcoholic fatty liver disease (NAFLD) is currently considered an important component of metabolic syndrome (MetS). The spectrum of NAFLD includes conditions that range from simple hepatic steatosis to non-alcoholic steatohepatitis. NAFLD is correlated with liver-related death and is predicted to be the most frequent indication for liver transplantation by 2030. Insulin resistance is directly correlated to the central mechanisms of hepatic steatosis in NAFLD patients, which is strongly correlated to the imbalance of the renin-angiotensin system, that is involved in lipid and glucose metabolism...
April 10, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29632405/combined-effect-of-renal-function-and-serum-potassium-level-in-sudden-cardiac-death-in-aging-hypertensive-subjects
#13
Jean-Pierre Fauvel, Francois Gueyffier, Lutgarde Thijs, Michel Ducher
In patients with chronic kidney disease, serum potassium level is a factor influencing sudden cardiac death (SCD). The aim of our analysis was to study the combined effect of serum potassium level and renal function on the onset of SCD in elderly hypertensive subjects. Data from the 3620 hypertensive patients aged over 70 years were extracted from three randomized clinical trials included in the INDANA database. During a mean follow up of 4.5 years, 81 patients (2.24%) died from SCD. Mean serum potassium levels and prevalence of chronic kidney disease were not different in patients who died from SCD...
April 9, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29626209/xrcc3-polymorphism-is-associated-with-hypertension-induced-left-ventricular-hypertrophy
#14
Andi Ariyandy, Chiemi Sakai, Mari Ishida, Ryusei Mizuta, Kiyoshi Miyagawa, Satoshi Tashiro, Aiko Kinomura, Koji Hiraaki, Keitaro Ueda, Masao Yoshizumi, Takafumi Ishida
Deficiency of X-ray repair cross-complementing protein 3 (XRCC3), a DNA-damage repair molecule, and the 241Met variant of XRCC3 have been reported to increase endoreduplication, which induces polyploidy. The aims of this study were to determine the impact of the XRCC3 polymorphism on the incidence of hypertension-induced left ventricular hypertrophy (LVH) and to investigate the mechanisms underlying any potential relationship. Patients undergoing chronic hemodialysis (n = 77) were genotyped to assess for the XRCC3 Thr241Met polymorphism...
April 6, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29618841/greater-reductions-in-plasma-aldosterone-with-aliskiren-in-hypertensive-patients-with-higher-soluble-pro-renin-receptor-level
#15
Kanako Bokuda, Satoshi Morimoto, Yasufumi Seki, Midori Yatabe, Daisuke Watanabe, Junichi Yatabe, Takashi Ando, Satoru Shimizu, Hiroshi Itoh, Atsuhiro Ichihara
The (pro)renin receptor is important in the regulation of the tissue renin-angiotensin-aldosterone system. The benefits and safety of single-aliskiren treatment without other renin-angiotensin-aldosterone system inhibitors remain unclear. The serum level of the soluble form of the (pro)renin receptor is thought to be a biomarker reflecting the activity of the tissue renin-angiotensin-aldosterone system. We investigated the effects of single renin-angiotensin-aldosterone system blockade with aliskiren on renal and vascular functions and determined if serum level of the soluble (pro)renin receptor was a predictor of aliskiren efficacy in hypertensive patients with chronic kidney disease...
April 4, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29568075/inhibition-of-endothelial-nitric-oxide-synthase-reverses-the-effect-of-exercise-on-improving-cognitive-function-in-hypertensive-rats
#16
Liying Zhang, Haiqing Zheng, Jing Luo, Lili Li, Xiaona Pan, Ting Jiang, Chongjun Xiao, Zhong Pei, Xiquan Hu
Hypertension-induced endothelial dysfunction is associated with β-amyloid (Aβ) deposition, a typical pathology of Alzheimer's disease (AD). Endothelial nitric oxide synthase (eNOS) phosphorylation, impaired by phosphatidylinositol 3-kinase (PI3K)/protein kinase-B(Akt) pathway abnormalities in hypertensive rats, has a critical role in endothelial function. However, it is unknown whether eNOS participates in the hypertension-induced pathology of AD. In this study, we investigated the role of eNOS in Aβ deposition and cognitive function in stroke-prone spontaneously hypertensive (SHRSP) rats...
March 22, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29559690/estimated-glomerular-filtration-ratio-is-a-better-index-than-creatinine-clearance-cockcroft-gault-for-predicting-the-prevalence-of-atrial-fibrillation-in-the-general-japanese-population
#17
Yutaka Yonezawa, Shigeo Horinaka, Chiaki Shirakawa, Yoshio Kogure
Direct oral anti-coagulants (DOACs) have been used in patients with non-valvular atrial fibrillation (AF), and renal function evaluation using the CCr (Cockcroft-Gault) is recommended as a criterion for the reduction of DOAC. In contrast, estimated glomerular filtration rate (eGFR) is usually used as an index of renal function in daily practice. We determined the age- and gender-specific prevalence rates of AF and whether CCr or eGFR was associated with the prevalence of AF. Data from the periodic health examinations of 108,951 subjects were collected...
March 20, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29556095/igf-1-receptor-cleavage-in-hypertension
#18
Selma Cirrik, Geert W Schmid-Schönbein
Increased protease activity causes receptor dysfunction due to extracellular cleavage of different membrane receptors in hypertension. The vasodilatory effects of insulin-like growth factor-1 (IGF-1) are decreased in hypertension. Therefore, in the present study the association of an enhanced protease activity and IGF-1 receptor cleavage was investigated using the spontaneously hypertensive rats (SHRs) and their normotensive Wistar Kyoto (WKY) controls (n = 4). Matrix metalloproteinase (MMP) activities were determined using gelatin zymography on plasma and different tissue samples...
March 19, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29556094/home-sphygmomanometers-can-help-in-the-control-of-blood-pressure-a-nationwide-field-survey
#19
Tekin Akpolat, Mustafa Arici, Sule Sengul, Ulver Derici, Sukru Ulusoy, Sehsuvar Erturk, Yunus Erdem
Home blood pressure monitoring (HBPM), which integrates patients into their treatment program, is a self-management tool. The prevalence of home sphygmomanometer ownership and patient compliance with HBPM guidelines are not well known, especially in developing and underdeveloped countries. The aims of this study were to measure the prevalence of home sphygmomanometer ownership among hypertensive subjects through a nationwide field survey (PatenT2), to investigate the validation of sphygmomanometers and consistency of the user arm circumference and cuff size of the upper-arm device owned, as well as to compare blood pressure (BP) readings between hypertensive subjects who have or do not have a sphygmomanometer...
March 19, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29556093/hypertension-with-diabetes-mellitus-physiology-and-pathology
#20
REVIEW
Mitsuru Ohishi
Elevated blood pressure is closely related to increased circulatory fluid volume and peripheral vascular resistance. Patients with diabetes mellitus experience increased peripheral artery resistance caused by vascular remodeling and increased body fluid volume associated with insulin resistance-induced hyperinsulinemia and hyperglycemia. Both of these mechanisms elevate systemic blood pressure. Thus, fully understanding the pathophysiology of hypertension in diabetes mellitus requires knowing the natural history of type 2 diabetes...
March 19, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
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