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Hypertension Research: Official Journal of the Japanese Society of Hypertension

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https://www.readbyqxmd.com/read/29142264/impairment-of-bkca-channels-in-human-placental-chorionic-plate-arteries-is-potentially-relevant-to-the-development-of-preeclampsia
#1
Mengzhou He, Fanfan Li, Meitao Yang, Yao Fan, Rajluxmee Beejadhursing, Yin Xie, Yuan Zhou, Dongrui Deng
Preeclampsia has known associations with insufficient placental perfusion. The large-conductance Ca(2+)-activated K(+) (BKca) channels that have recently been found to play important roles in cellular growth and vasodilatation could potentially participate in the development of preeclampsia. However, the mechanisms by which downregulated BKca channels are involved in the development of preeclampsia remain unknown. In this study, we investigated the mechanism(s) underlying the impairment of vascular tone regulation by BKca channels in human placental chorionic plate arteries (CPAs) in preeclampsia...
November 16, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29118329/aortic-stiffness-improves-the-prediction-of-both-diagnosis-and-severity-of-coronary-artery-disease
#2
Alexandra Yannoutsos, Mathieu Ahouah, Céline Dreyfuss Tubiana, Jirar Topouchian, Michel E Safar, Jacques Blacher
Elective coronography has low diagnostic yield for obstructive coronary artery disease (CAD). We aim to determine whether non-invasive aortic stiffness assessment improves diagnostic accuracy of CAD screening by reducing the number of false-positive results from the cardiac stress test. A cross-sectional study was conducted from January 2013 to September 2014 in our medical center. Electrocardiogram (ECG) stress test coupled with nuclear imaging was performed in 367 consecutive patients routinely followed for myocardial ischemia screening...
November 9, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29093567/atrial-fibrillation-does-not-affect-ankle-brachial-index-measured-using-the-doppler-method
#3
Michał Dąbrowski, Jacek Lewandowski, Piotr Abramczyk, Izabela Łoń, Zbigniew Gaciong, Maciej Siński
Atrial fibrillation may affect blood pressure measurements. The ankle-brachial index (ABI) is a ratio of systolic blood pressure measured on the lower and upper limbs that may also be affected by arrhythmia. The purpose of the study was to investigate whether atrial fibrillation influenced ABI results. Ninety-nine patients (age 66.6±11 years, 63 males and 36 females) who underwent electrical cardioversion of atrial fibrillation were investigated. ABI measurements using the Doppler method were performed on both lower extremities before and after electrical cardioversion...
November 2, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29093566/hypertension-induces-additional-cardiometabolic-impairments-and-attenuates-aerobic-exercise-training-adaptations-in-fructose-fed-ovariectomized-rats
#4
Janaina de O Brito-Monzani, Iris Callado Sanches, Nathalia Bernardes, Kátia Ponciano, Ivana C Moraes-Silva, Maria-Cláudia Irigoyen, Susana Llesuy, Kátia De Angelis
We tested whether hypertension favors the development of additional cardiometabolic changes in fructose-fed ovariectomized rats and how it affects aerobic exercise training (ET) effects. All rats received fructose in drinking water (10%) beginning at weaning, were ovariectomized at 10 weeks of age and divided into the normotensive sedentary (NFOS) and trained (NFOT) and hypertensive sedentary (HFOS) and trained (HFOT) groups. ET was performed on a treadmill. Arterial pressure (AP) was directly recorded; heart rate and AP variabilities were analyzed...
November 2, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29093565/effect-of-blood-pressure-on-reversible-posterior-leukoencephalopathy-syndrome-in-pre-eclampsia-or-eclampsia
#5
Fang Xiaobo, Liang Yanling, Chen Dunjin, He Fang, Chen Jia, Zhong Yuhua, Zhang Weixi
Reversible posterior leukoencephalopathy syndrome (RPLS) is a critical maternal complication in some pre-eclampsia (PE) and nearly all eclampsia patients; RPLS is associated with high blood pressure (BP). However, the effect of BP on RPLS and the different characteristics of RPLS in PE or eclampsia are largely unknown. We consecutively collected data from 69 patients who were diagnosed with RPLS in PE or eclampsia between 2013 and 2017. The BP and biochemical indicators at onset and post onset of RPLS were examined to explore their likely correlation with RPLS...
November 2, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29093564/a-case-control-study-between-the-stim1-gene-and-hypertensive-disorders-of-pregnancy
#6
Kaori Shinya, Tomohiro Nakayama, Takuo Nakayama, Tatsuo Yamamoto
Hypertensive disorders of pregnancy (HDP) is a common disease and is believed to be a multifactorial genetic disease. Stromal interaction molecule 1 (STIM1) was previously reported to regulate the concentration of Ca(2+) and vascular contraction. The aim of the present study was to assess the association between HDP and single-nucleotide polymorphisms (SNPs) or haplotypes in the human STIM1 gene via case-control studies. On the basis of a database on the National Center of Biotechnology Information website, we selected five SNPs in the human STIM1 gene and performed an association study with 139 HDP patients and 162 age-matched non-HDP subjects...
November 2, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29093563/bkca-channel-activity-and-vascular-contractility-alterations-with-hypertension-and-aging-via-%C3%AE-1-subunit-promoter-methylation-in-mesenteric-arteries
#7
Yanyan Zhang, Jingwen Liao, Lin Zhang, Shanshan Li, Ying Wu, Lijun Shi
Promoter methylation is a key mechanism in the epigenetic reprogramming of gene expression patterns. Here, we investigated the contribution of DNA methylation and the associated expression and function of large-conductance Ca(2+)-activated K(+) (BKCa) channel in mesenteric arteries when hypertension was superimposed on aging. Male Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) at young (12 weeks), adult (36 weeks) and old (64 weeks) life stages were used. BKCa channel currents, BKCa channel activity in regulating vascular tone, and BKCa channel β1 subunit (BKβ1) function and expression were greater in mesenteric arteries from SHR than from age-matched WKY controls...
November 2, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29093562/glucocorticoid-exposure-induces-preeclampsia-via-dampening-1-25-dihydroxyvitamin-d3
#8
Dongxin Zhang, Ji Zeng, Xili Miao, Haojing Liu, Liangfang Ge, Wei Huang, Jinyu Jiao, Duyun Ye
The pathogenesis of preeclampsia (PE) involves a number of biological processes that may be directly or indirectly affected by glucocorticoid (GC) and vitamin D. GC exposure increases the risk of PE, and 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) deficiency may result in PE. The purpose of the present study was to confirm the involvement of GC/1,25-(OH)2D3 axis in the pathogenesis of PE. In the study, cortisol levels of PE patients were found to be higher than that of non-complicated pregnancies, while 1,25-(OH)2D3 were decreased in both PE women and GC-induced PE rats...
November 2, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29093561/hypertensive-disorders-of-pregnancy-a-strong-risk-factor-for-subsequent-hypertension-5-years-after-delivery
#9
Asako Mito, Naoko Arata, Dongmei Qiu, Naoko Sakamoto, Atsuko Murashima, Atsuhiro Ichihara, Ryu Matsuoka, Akihiko Sekizawa, Yukihiro Ohya, Michihiro Kitagawa
Hypertensive disorders of pregnancy are known to be a risk factor for future cardiovascular diseases. In contrast, there is a paucity of data on the not so distant future prognosis of hypertensive disorders of pregnancy. In the present study, we evaluated the incidence of the diseases causing cardiovascular problems (hypertension, diabetes mellitus, dyslipidemia and metabolic syndrome) 5 years after delivery in Japanese women with hypertensive disorders of pregnancy. We performed a double-cohort study and compared medical conditions between women with and without a history of hypertensive disorders of pregnancy...
November 2, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29070830/environmental-stress-and-vestibular-inputs-modulate-cardiovascular-responses-to-orthostasis-in-hypertensive-rats
#10
Gábor Raffai, Csongor Csekő, György Nádasy, László Kocsis, László Dézsi, Stephen N Hunyor, Emil Monos
The frequent accompaniment of hypertension by orthostatic circulatory disorders prompted us to investigate the effect of repeated and sustained head-up and head-down tilt positions on cardiovascular responses in spontaneously hypertensive rats vs. Wistar rats using radiotelemetric implants. Repeated orthostasis caused a transient elevation in blood pressure (7.3±1.7 mmHg) and heart rate (39.7±10.5 BPM), while repeated antiorthostasis led only to reversible tachycardia (85.6±11.7-54.3±16.8 BPM) in spontaneously hypertensive rats...
October 26, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29070829/hemoglobin-a1c-and-c-reactive-protein-are-independently-associated-with-blunted-nocturnal-blood-pressure-dipping-in-obesity-related-prediabetes
#11
Abbi D Lane-Cordova, Graziela Z Kalil, Christopher J Wagner, Amy L Sindler, Jess G Fiedorowicz, Tiwaloluwa Ajibewa, William G Haynes, Gary L Pierce
Blunted nocturnal dipping in blood pressure (BP) is associated with increased cardiovascular disease (CVD) risk in middle-aged/older adults. The prevalence of blunted nocturnal BP dipping is higher in persons with obesity and diabetes, conditions that are also associated with elevated aortic stiffness and inflammation. Therefore, we hypothesized that elevated glycemia, inflammation and aortic stiffness would be inversely associated with the magnitude of nocturnal systolic BP dipping among middle-aged/older adults with obesity at high CVD risk...
October 26, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29070828/high-blood-pressure-and-its-relationship-to-adiposity-in-a-school-aged-population-body-mass-index-vs-waist-circumference
#12
William Rodrigues Tebar, Raphael Mendes Ritti-Dias, Breno Quintella Farah, Edner Fernando Zanuto, Luiz Carlos Marques Vanderlei, Diego Giulliano Destro Christofaro
High blood pressure (HBP) is a major concern in pediatric populations. Adiposity is highly related to HBP in youths; however, whether body mass index (BMI) or waist circumference (WC) is more strongly associated with HBP in this population is unclear. This cross-sectional study, involving schoolchildren between 10 and 17 years of age from public and private schools, assessed direct measurements of BMI, WC and blood pressure. The socioeconomic level, sedentary behavior, physical activity, alcohol consumption and smoking history were obtained through a questionnaire...
October 26, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29046520/the-impact-of-salt-intake-during-and-after-pregnancy
#13
Kei Asayama, Yutaka Imai
Although high blood pressure before pregnancy is associated with a risk of gestational hypertension and preeclampsia, no convincing evidence has been produced to show that dietary salt reduction helps in the prevention and treatment of hypertension during pregnancy. Thus the current guidelines do not recommend a sodium restriction during pregnancy to prevent gestational hypertension and the development of preeclampsia. However, the long-term impact of hypertensive disorders of pregnancy for life-threatening diseases later in life is a critical issue...
October 19, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29046519/the-effects-of-anti-hypertensive-drugs-and-the-mechanism-of-hypertension-in-vascular-smooth-muscle-cell-specific-atp2b1-knockout-mice
#14
Yuki Okuyama, Nobuhito Hirawa, Megumi Fujita, Akira Fujiwara, Yosuke Ehara, Keisuke Yatsu, Koichiro Sumida, Minako Kagimoto, Mari Katsumata, Yusuke Kobayashi, Sanae Saka, Satoshi Umemura, Kouichi Tamura
ATP2B1 is a gene associated with hypertension. We reported previously that mice lacking ATP2B1 in vascular smooth muscle cells (VSMC ATP2B1 KO mice) exhibited high blood pressure and increased intracellular calcium concentration. The present study was designed to investigate whether lack of the ATP2B1 gene causes a higher response to calcium channel blockers (CCBs) than to other types of anti-hypertensive drugs. Both VSMC ATP2B1 KO and control mice were administered anti-hypertensive drugs while monitoring blood pressure shifts...
October 19, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28978988/effects-of-long-term-psychological-intervention-on-blood-pressure-and-health-related-quality-of-life-in-patients-with-hypertension-among-the-chinese-working-population
#15
Lei Liu, Min Li, Shaowu Song, Anshi Shi, Si Cheng, Xiawei Dang, Hui Chen, Heng Zhang, A Ziguli, Lifei Cao, Ping Wang, Hui Luan, Yunlong Ma, Songlin Zhang, Zengwu Wang, Xin Wang, Runlin Gao, Gang Tian
The aim of this study was to analyze the effects of psychological intervention on blood pressure, health-related quality-of-life (HRQOL), and stroke prevalence in patients with hypertension among the Chinese working population. Cluster sampling was conducted in September 2013 at the Shaanxi Jinduicheng Molybdenum Group General Hospital (intervention group) and the Shaanxi Province Hancheng Mining Bureau General Hospital (control group). The intervention group received regular psychological intervention for 2 years, including cognitive, emotional, and behavioral interventions...
October 5, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28978987/validity-of-the-augmentation-index-and-pulse-pressure-amplification-as-determined-by-the-sphygmocor-xcel-device-a-comparison-with-invasive-measurements
#16
Atsushi Nakagomi, Toshihiro Shoji, Sho Okada, Yuji Ohno, Yoshio Kobayashi
Augmentation index (AIx) and pulse pressure (PP) amplification can be determined by the SphygmoCor XCEL device in an operator-independent manner. This study aimed to examine its validity against invasive measurements. Simultaneous recordings of central aortic pressure waveforms were performed with oscillometric and high-fidelity invasive methods in 35 patients who underwent coronary arteriography. Brachial blood pressure was also recorded using the two methods. AIx for the aortic pressure waveform was defined as the ratio of augmentation pressure to PP...
October 5, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28978986/the-relationship-between-obesity-and-hypertension-an-updated-comprehensive-overview-on-vicious-twins
#17
REVIEW
Massimo Leggio, Mario Lombardi, Elisa Caldarone, Paolo Severi, Stefania D'Emidio, Massimo Armeni, Veronica Bravi, Maria Grazia Bendini, Andrea Mazza
Obesity is a growing global health concern, with a rapid increase being observed in morbid obesity. Obesity is associated with an increased cardiovascular risk and earlier onset of cardiovascular morbidity. The growing obesity epidemic is a major source of unsustainable health costs and morbidity and mortality because of hypertension, type 2 diabetes mellitus, dyslipidemia, certain cancers and major cardiovascular diseases. Similar to obesity, hypertension is a key unfavorable health metric that has disastrous health implications: currently, hypertension is the leading contributor to global disease burden, and the direct and indirect costs of treating hypertension are exponentially higher...
October 5, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28978985/impact-of-nocturnal-blood-pressure-variability-on-renal-arterioles
#18
Haruhito A Uchida, Masashi Kitagawa, Jun Wada
No abstract text is available yet for this article.
October 5, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28978984/genetic-risk-factors-influence-nighttime-blood-pressure-and-related-cardiovascular-complications-in-patients-with-coronary-heart-disease
#19
Marcin Wirtwein, Olle Melander, Marketa Sjőgren, Michal Hoffmann, Krzysztof Narkiewicz, Marcin Gruchala, Wojciech Sobiczewski
Genetic predisposition of elevated nighttime blood pressure (BP) in patients with coronary heart disease is unknown. We evaluated genetic predisposition and the relationship between elevated nighttime BP and cardiovascular complications over a median of 8.6 years of observation of hypertensive subjects with coronary atherosclerosis confirmed by coronary angiography. Genetic Risk Score (GRS19) was constructed to evaluate the additive effect of single-nucleotide polymorphisms for daytime and nighttime BP. The Receiver Operating Characteristic was used for determination of cutoff points for daytime BP (systolic BP (SBP) 133 mm Hg and diastolic BP (DBP) 77 mm Hg) and nighttime BP (SBP 122 mm Hg and DBP 73 mm Hg)...
October 5, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28978983/body-mass-index-and-contralateral-ratio-predict-outcome-following-unilateral-adrenalectomy-in-primary-aldosteronism
#20
Kanako Bokuda, Midori Yatabe, Yuki Mizuguchi, Michita Niiyama, Yasufumi Seki, Daisuke Watanabe, Junichi Yatabe, Takashi Ando, Satoshi Morimoto, Atsuhiro Ichihara
The effect of unilateral adrenalectomy on blood pressure (BP) outcome in primary aldosteronism (PA) is diverse. Therefore, we sought to investigate the preoperative factors contributing to postoperative BP outcome. Data for 96 PA patients who underwent unilateral adrenalectomy at our institution from January 2000 to February 2015 were retrospectively collected. Based on postoperative BP after a 12-month follow-up period, the patients were categorized into two groups: cured (C) (<140/90 mm Hg with no antihypertensive drug) and not cured (NC) (if not normotensive)...
October 5, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
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