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Hypertension Research: Official Journal of the Japanese Society of Hypertension

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https://www.readbyqxmd.com/read/30218050/association-between-socioeconomic-factors-and-urinary-sodium-to-potassium-ratio-the-nagahama-study
#1
Makoto Yamashita, Yasuharu Tabara, Yukiko Higo, Kazuya Setoh, Takahisa Kawaguchi, Yoshimitsu Takahashi, Shinji Kosugi, Takeo Nakayama, Fumihiko Matsuda, Tomoko Wakamura
High sodium intake is a simple modifiable risk factor for hypertension. Although not confirmed, lower socioeconomic status may be a factor that increases sodium intake. We aimed to clarify the association between socioeconomic status and urinary sodium-to-potassium ratio by cross-sectional and longitudinal analyses. The study included 9410 community residents. Spot urine sodium-to-potassium ratios were measured twice with a 5-year interval. Socioeconomic status was investigated using a self-administered questionnaire...
September 14, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30218049/sex-differences-and-the-prognosis-of-depressive-and-nondepressive-patients-with-cardiovascular-risk-factors-the-japan-morning-surge-home-blood-pressure-j-hop-study
#2
Tomoyuki Kabutoya, Satoshi Hoshide, Karina W Davidson, Kazuomi Kario
Depression is associated with mortality in patients with cardiovascular risk factors. The frequency and severity of depression and the association between depression and cardiovascular events have sex-specific and ethnic differences. We conducted this study to evaluate the sex-specific difference in the association between depression and cardiovascular prognosis in patients with cardiovascular risk factors. We enrolled 4025 patients (64.7 ± 10.9 years, 53% women, 47% men) with cardiovascular risk factors in the Japan Morning Surge-Home Blood Pressure study...
September 14, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30214031/application-of-laser-scanning-cytometry-in-vascular-smooth-muscle-remodeling
#3
Dina Johar, Sameh Magdeldin
Pulmonary artery hyperplasia is the result of proliferation of the pulmonary arterial smooth muscles (PASM). Hypoxia-induced PASM proliferation in the fetus and the newborn is the primary cause of persistent pulmonary hypertension of the newborn (PPHN). This study was performed to characterize the utility of the Laser Scanning Cytometry (LSC) method in elucidating arterial cytoskeletal remodeling in an in vitro model of PPHN. The aim was to demonstrate the following: (a) LSC is a valid method for the analysis of nuclear and cytosolic fluorescence and (b) the cumulative effects of mechanical stretch together with hypoxia promote reactive oxygen species (ROS) formation...
September 13, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30214030/novel-biomarker-profiles-in-experimental-aged-maternal-mice-with-hypertensive-disorders-of-pregnancy
#4
Kiichiro Furuya, Keiichi Kumasawa, Hitomi Nakamura, Katsuhiko Nishimori, Tadashi Kimura
Recently, advanced maternal age (AMA) has increased in Western countries because of late marriage and advances in assisted reproductive technology. One major complication of AMA is hypertensive disorders of pregnancy (HDP). While clinical investigations into human AMA have been reported, there has been limited information obtained from basic research. In this investigation, we established the AMA mouse model using aged pregnant ICR mice. We demonstrated that the phenotypes of aged pregnant ICR mice reflect the same characteristics as human AMA...
September 13, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30209284/urinary-sodium-to-potassium-ratio-and-serum-asymmetric-dimethylarginine-levels-in-patients-with-type-2-diabetes
#5
Miyuki Yokoro, Miki Minami, Sumire Okada, Megumu Yano, Naoto Otaki, Hiroki Ikeda, Keisuke Fukuo
Obesity modifies the association between sodium and potassium intake and blood pressure. However, the impact of obesity on the relationship between the sodium-potassium balance and cardiovascular risk in type 2 diabetes (T2DM) patients remains unclear. We investigated the relationship between the 24-h urinary sodium-to-potassium ratio and serum asymmetric dimethylarginine (ADMA) level, which is a cardiovascular risk factor, in Japanese T2D patients with or without obesity. This cross-sectional study included 243 patients with T2DM who were hospitalized for diabetes education...
September 12, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30209283/azilsartan-attenuates-cardiac-damage-caused-by-high-salt-intake-through-the-downregulation-of-the-cardiac-pro-renin-receptor-and-its-downstream-signals-in-spontaneously-hypertensive-rats
#6
Hisaaki Komaki, Masamitsu Iwasa, Yuka Hayakawa, Chihiro Okamoto, Shingo Minatoguchi, Yoshihisa Yamada, Hiromitsu Kanamori, Masanori Kawasaki, Kazuhiko Nishigaki, Shinya Minatoguchi
We examined whether the stimulation of the angiotensin II AT1 receptor increases the expression of the cardiac (pro)renin receptor ((P)RR) and its downstream signals and whether the blockade of the angiotensin II AT1 receptor by azilsartan decreases the expression of the cardiac (P)RR and its signaling in spontaneously hypertensive rats (SHRs) with a high-salt intake. Rats received normal-salt (0.9%) chow, high-salt (8.9%) chow, normal-salt chow with 1 mg/day of azilsartan, and high-salt chow with 1 mg/day of azilsartan from 6 to 12 weeks of age...
September 12, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30209282/pde3a-gene-screening-improves-diagnostics-for-patients-with-bilginturan-syndrome-hypertension-and-brachydactyly-syndrome
#7
Kirsten Y Renkema, Jonne M Westermann, Rutger A J Nievelstein, Shirley M Lo-A-Njoe, Bert van der Zwaag, Meindert E Manshande, Mieke M van Haelst
Autosomal-dominant hypertension and brachydactyly syndrome (HTNB; Bilginturan syndrome) is known to cause stroke before age 50 when untreated. We report a novel PDE3A gene mutation in a mother and daughter affected with dominant brachydactyly of the hands and feet, a short stature, and hypertension. The hypertension was medically responsive to anti-hypertensive treatment. The 3-bp deletion in the PDE3A gene presented de novo in the mother. Here, we expand the list of PDE3A mutations identified in Bilginturan syndrome and emphasize the importance of standardized genetic testing of HTNB patients to improve diagnostics at an early age...
September 12, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30206324/central-and-peripheral-blood-pressure-response-to-a-single-bout-of-an-exercise-session-in-patients-with-resistant-hypertension
#8
LETTER
Fernando Ribeiro, Nádia Almeida, Raquel Ferreira, Nórton Oliveira, José Oliveira, Alberto J Alves, José Mesquita-Bastos
No abstract text is available yet for this article.
September 11, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30206323/microvascular-endothelial-function-is-impaired-in-patients-with-idiopathic-hyperaldosteronism
#9
Shinji Kishimoto, Takeshi Matsumoto, Kenji Oki, Tatsuya Maruhashi, Masato Kajikawa, Shogo Matsui, Haruki Hashimoto, Yasuki Kihara, Farina Mohamad Yusoff, Yukihito Higashi
The aims were to evaluate the relationship between idiopathic hyperaldosteronism (IHA) and grade of vascular function in the macrovasculature and microvasculature. Vascular function, including reactive hyperemia index (RIH), flow-mediated vasodilation (FMD), and nitroglycerine-induced vasodilation (NID) were evaluated in 52 patients with IHA, 53 patients with aldosterone-producing adenoma (APA), and 52 age-, sex-, and blood pressure-matched patients with essential hypertension (EHT). Log RHI was lower in the IHA and APA groups than in the EHT group (0...
September 11, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30206322/impact-of-obstructive-sleep-apnea-on-long-term-blood-pressure-variability-in-japanese-men-a-cross-sectional-study-of-a-work-site-population
#10
Yasuo Kansui, Kiyoshi Matsumura, Yuki Morinaga, Minako Inoue, Satoko Sakata, Emi Oishi, Kenichi Goto, Toshio Ohtsubo, Hiroaki Ooboshi, Takanari Kitazono
Blood pressure variability (BPV) has been shown to be associated with cardiovascular diseases. The effects on long-term BPV of obstructive sleep apnea (OSA) are not yet known. We evaluated a total of 1653 Japanese male workers (18-69 years) at a work site to diagnose OSA, and we divided them into three groups: non-OSA (apnea-hypopnea index (AHI): < 5, n = 1414), mild-to-moderate OSA (5 ≤ AHI < 30: n = 131) and severe OSA (AHI ≥ 30: n = 108). The standard deviation and coefficient of variation of the subjects' BPV were calculated by using their annual blood pressure measurements at routine physical examinations from 2012 to 2015 (four measurements)...
September 11, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30185927/effects-of-uric-acid-on-vascular-endothelial-function-from-bedside-to-bench
#11
Naoyuki Otani, Shigeru Toyoda, Masashi Sakuma, Keitaro Hayashi, Motoshi Ouchi, Tomoe Fujita, Naohiko Anzai, Atsushi Tanaka, Koichi Node, Naoto Uemura, Teruo Inoue
This study was designed to investigate the effects of uric acid on vascular endothelial function in measurements carried out either at the bedside or the laboratory bench. First, we performed reactive hyperemia peripheral arterial tonometry using an EndoPAT 2000 device and measured serum uric acid levels in 92 outpatients with hypertension. The reactive hyperemia index (RHI) showed no correlation with serum uric acid level (R = -0.125, P = 0.235) in either overall patients or in a high-risk group of 51 patients with complications such as cardiovascular and cerebrovascular diseases, chronic kidney disease, and/or diabetes (R = -0...
September 5, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30166614/early-myocardial-changes-in-normotensive-children-of-hypertensive-parents-a-tissue-doppler-study
#12
Pelin Kosger, Gokmen Ozdemir, Ali Yildirim, Birsen Ucar, Zubeyir Kilic
The aim of this study was to examine early left ventricular systolic and diastolic changes using tissue Doppler imaging (TDI) in normotensive children of hypertensive parents (NCHP), a risk group for cardiovascular diseases. Ninety-two children characterized as NCHP (age range: 6-18 years) and 90 age-, gender-, height-, weight-, and body mass index-matched children characterized as normotensive children of normotensive parents (NCNP) were included in the study. Left ventricular diastolic parameters were assessed using transmitral flow pulse wave Doppler echocardiography and mitral septal and lateral annular TDI...
August 31, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30154504/clinical-evaluation-of-an-optical-fiber-based-probe-for-the-assessment-of-central-arterial-pulse-waves
#13
Cátia Leitão, Verónica Ribau, Vera Afreixo, Paulo Antunes, Paulo André, João L Pinto, Pierre Boutouyrie, Stéphane Laurent, J Mesquita Bastos
The aim of this study, enrolling 118 patients, was to clinically evaluate the accuracy of carotid pulse waveform acquisition with a new non-invasive optical fiber probe using invasive and non-invasive pressure readings as references. Pulse waves were acquired simultaneously in the ascending aorta and right common carotid; for the non-invasive study, the pulses were sequentially acquired using the optical fiber device and the Complior Analyse® (Alam Medical, France) device in the right carotid artery. For all subjects, the pulse waveforms assessed using the optical fiber sensor and the references were superimposed to analyze the deviation and point-by-point correlation...
August 28, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30127349/urinary-sodium-excretion-and-risk-of-cardiovascular-disease-in-the-chinese-population-a-prospective-study
#14
Huanhuan Liu, Xiangmin Gao, Long Zhou, Yong Wu, Ying Li, Jinzhuang Mai, Zhiqiang Nie, Yangfeng Wu, Xiaoqing Liu, Liancheng Zhao
The effect of dietary sodium (salt) on cardiovascular disease (CVD) has been debated for a long time. The present study aims to explore whether salt intake affects the risk of cardiovascular disease in the Chinese population. Data from a prospective cohort study that included 954 men and women aged 35-59 years at baseline from four urban and rural population samples in China were used. Each participant collected their overnight urine for three consecutive days during two seasons to estimate sodium intake. CVD events, including incidences of coronary heart disease (CHD), stroke, and death from CVD, and all-cause mortality were tested by Cox proportional hazards models...
August 20, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30120397/hypertension-induced-cognitive-impairment-insights-from-prolonged-angiotensin-ii-infusion-in-mice
#15
Sébastien Foulquier, Pawel Namsolleck, Britt T Van Hagen, Irina Milanova, Mark J Post, W Matthijs Blankesteijn, Bart P Rutten, Jos Prickaerts, Robert J Van Oostenbrugge, Thomas Unger
The causal relation between hypertension and cerebral small vessel disease (cSVD) remains elusive, and appropriate animal models are scarce. We aimed to assess the relevance of prolonged angiotensin II-induced hypertension in mice for the study of cSVD.Adult male C57BL/6 mice were continuously infused for 3 months with Angiotensin II (Ang II; 2 µg/kg/min, sc) or saline (control) via osmotic minipumps. Blood pressure, neurological function, locomotor activity, and working memory (Y-maze alternation task) were assessed throughout the study...
August 17, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30120396/intracerebroventricular-administration-of-bone-marrow-derived-cells-attenuates-angiotensin-ii-initiated-neurogenic-hypertension-in-rats
#16
Masanobu Yamazato, Akio Ishida, Yoriko Yamazato, Takuto Nakamura, Yusuke Ohya
Bone marrow-derived cells exert anti-inflammatory actions and can migrate into the brain. However, their role in the development of neurogenic hypertension remains unclear. A hyperactive renin-angiotensin system and inflammation in the brain are mechanisms that contribute to angiotensin II-initiated neurogenic hypertension. We hypothesized that bone marrow-derived cells in the brain attenuate the overactive brain renin-angiotensin system and inflammation, thereby reducing neurogenic hypertension. We cultured plastic-adherent bone marrow-derived cells for 3 weeks...
August 17, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30120395/early-detection-of-microvascular-dysfunction-in-hypertension-the-holy-grail-of-cardiovascular-prevention-and-risk-assessment
#17
EDITORIAL
Adam Domonkos Tarnoki, David Laszlo Tarnoki, Giacomo Pucci
No abstract text is available yet for this article.
August 17, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30111856/vasorelaxant-effect-of-sinensetin-via-the-no-sgc-cgmp-pathway-and-potassium-and-calcium-channels
#18
Mun Fei Yam, Chu Shan Tan, Ruan Shibao
Orthosiphon stamineus Benth. (Lambiaceae) is an important traditional plant for the treatment of hypertension. Previous studies have demonstrated that the sinensetin content in O. stamineus is correlated with its vasorelaxant activity. However, there is still very little information regarding the vasorelaxant effect of sinensetin due to a lack of scientific studies. Therefore, the present study was designed to investigate the underlying mechanism of action of sinensetin in vasorelaxation using an in vitro precontraction aortic ring assay...
August 15, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30111855/an-interesting-cross-talk-between-the-glucagon-like-peptide-1-receptor-axis-and-angiotensin-receptor-pathway-for-modulation-of-renal-sodium-handling-in-obesity
#19
EDITORIAL
Kouichi Tamura, Takahiro Yamaji, Takayuki Yamada, Masato Ohsawa, Hiromichi Wakui
No abstract text is available yet for this article.
August 15, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30108340/never-give-up-correcting-your-lifestyle-the-beginning-is-always-the-hardest
#20
EDITORIAL
Tatsuo Shimosawa
No abstract text is available yet for this article.
August 14, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
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