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Cell Biology International

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https://www.readbyqxmd.com/read/28418174/hypoxia-upregulates-integrin-gene-expression-in-microvascular-endothelial-cells-and-promotes-their-migration-and-capillary-like-tube-formation
#1
Christina Befani, Panagiotis Liakos
Tissue hypoxia affects gene expression through the hypoxia-inducible transcription factors, HIF-1 and HIF-2, in both physiological and pathological angiogenesis. Angiogenesis is a complex response of endothelial cells integrating cell proliferation, migration, tube formation and their interaction with the extracellular matrix through integrin receptors. In this report, we studied the effect of hypoxia on the angiogenic functions of human microvascular endothelial cells (HMEC-1) as well as on expression of the angiogenic integrins αν β3 , αν β5 and α5 β1 ...
April 18, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28418110/identification-of-circulating-mirna-involved-in-meat-yield-of-korean-cattle
#2
Surim Lee, Seung-Ju Park, Jae-Kyoung Cheong, Jong-Youl Ko, Jinjong Bong, Myunggi Baik
Cattle plays an important role in providing essential nutrients through meat production. Thus, we focused on epigenetic factors associated with meat yield. To investigating circulating miRNAs that are involved with meat yield and connect biofluids and longissimus dorsi (LD) muscle in Korean cattle, we performed analyses of the carcass characteristics, miRNA array, qPCR, and bioinformatics. Carcass characteristics relative to the yield grade (YG) showed that the yield index and rib eye area were the highest, whereas the backfat thickness was the lowest for YG A (equal to high yield grade) cattle among the three YGs...
April 18, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28403532/temozolomide-increases-mhc-i-expression-via-nf-%C3%AE%C2%BAb-signaling-in-glioma-stem-cells
#3
Dongyong Zhang, Bo Qiu, Yunjie Wang, Yanlei Guan, Luyang Zhang, Anhua Wu
Gliomas are the most common and primary tumors of the central nervous system in adults. Temozolomide (TMZ) is the main drug used to treat glioma, however, prognosis remains poor for most patients. Glioma stem cells (GSCs) are thought to enable glioma initiation and evasion from immune surveillance; their immunogenicity can be determined by expression of major histocompatibility complex (MHC)-I. The present study investigated the effect of TMZ on MHC-I expression in GSCs. Glioma spheres were cultured in serum-free medium containing epidermal growth factor, basic fibroblast growth factor, and B27; MHC-I expression was detected by immunocytochemistry, quantitative real-time PCR, and flow cytometry...
April 12, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28403524/human-mesenchymal-stem-cells-promote-cd34-hematopoietic-stem-cell-proliferation-with-preserved-red-blood-cell-differentiation-capacity
#4
Show Xuan Lau, Yin Yee Leong, Wai Hoe Ng, Albert Wee Po Ng, Ida Shazrina Ismail, Narazah Mohd Yusoff, Rajesh Ramasamy, Jun Jie Tan
Studies showed that co-transplantation of mesenchymal stem cells (MSCs) and cord blood-derived CD34(+) hematopoietic stem cells (HSCs) offered greater therapeutic effects but little is known regarding the effects of human Wharton's jelly-derived MSCs on HSC expansion and red blood cell (RBC) generation in vitro. This study aimed to investigate the effects of MSCs on HSC expansion and differentiation. HSCs were co-cultured with MSCs or with 10% MSCs-derived conditioned medium, with HSCs cultured under standard medium served as a control...
April 12, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28403518/formation-of-the-igf1r-cav1-src-tri-complex-antagonizes-trail-induced-apoptosis-in-gastric-cancer-cells
#5
Tianshu Guo, Ling Xu, Xiaofang Che, Simeng Zhang, Ce Li, Jin Wang, Jing Gong, Rui Ma, Yibo Fan, Kezuo Hou, Huiming Zhou, Xuejun Hu, Yunpeng Liu, Xiujuan Qu
Lipid rafts provide a biological platform for apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). We previously reported that insulin-like growth factor 1 receptor (IGF1R) translocation into lipid rafts helped to explain TRAIL resistance. However, it was not clear whether TRAIL resistance was caused by the interaction of IGF1R with caveolin-1 (CAV1) and the non-receptor tyrosine kinase SRC in lipid rafts of gastric cancer cells. Here, we observed high IGF1R expression in TRAIL-resistant gastric cancer cells, and showed that IGF1R combined with both CAV1 and SRC in a native complex...
April 12, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28387429/cytoskeletal-mechanisms-in-positioning-of-the-second-division-spindles-and-meiotic-restitution-in-tobacco-nicotiana-tabacum-l-microsporogenesis
#6
Yuriy Vladimirovich Sidorchuk, Elena Victorovna Deineko
Microsporogenesis patterns of the polyploid (2n = 4x = 96) and diploid (2n = 2x = 48) Nicotiana tabacum L. (cv. Havana Petit line SR1) plants have been analyzed and compared. Four types of abnormal positions of the second division spindles-tripolar, parallel, proximal, and fused-have been observed. Of these abnormalities, only tripolar (2.4%) and parallel (1.4%) spindles are observable in diploid plants. As for polyploids, the increased ploidy is accompanied by an increase in the incidence of tripolar (22.8%) and parallel (8...
April 7, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28378938/ag490-suppresses-interleukin-34-mediated-osteoclastogenesis-in-mice-bone-marrow-macrophages
#7
Xin Cheng, Qi-Long Wan, Zu-Bing Li
Interleukin-34 (IL-34) has been recently identified as a novel cytokine, substituting for the function of macrophage colony-stimulating factor (M-CSF), a pivotal osteoclastogenic factor involved in bone-related diseases (e.g., osteomyelitis of the jaws). However, the molecular mechanisms are not fully understood. This study aimed to explore the potential mechanism of IL-34 in receptor activator of NF-kB Ligand (RANKL)-induced osteoclast formation. We found that IL-34 alone significantly maintained the survival of bone-marrow macrophages (BMMs) and enhanced the expression of the osteoclast-related genes TRAP, Ctsk, and NFATc1, as well as TRAP-positive multinucleated cells combined with RANKL, which can be reversed by AG490...
April 5, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28370928/rho-kinase-regulates-extracellular-matrix-mediated-osteogenic-differentiation-of-periodontal-ligament-cells
#8
Yuki Ugawa, Tadashi Yamamoto, Mari Kawamura, Keisuke Yamashiro, Masayuki Shimoe, Kazuya Tomikawa, Shoichi Hongo, Hiroshi Maeda, Shogo Takashiba
The periodontal ligament (PDL) cells contain heterogeneous mesenchymal cell populations, which have the ability to differentiateinto cells that produce adjacent mineralized tissues and abundant extracellular matrix (ECM). ECM is essential not only for the homeostasis of the periodontal tissue, but also for controlling the differentiation of the PDL cells. The process of differentiation involves mechanotransduction, which links the ECM to the cytoskeleton. The present study investigated the roles of Rho-associated coiled-coil containing protein kinase (ROCK) signaling, a crucial regulator of the cytoskeleton, during ECM-mediated osteogenic differentiation of PDL cells in vitro...
March 29, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28370893/microrna-an-important-regulator-in-acute-myeloid-leukemia
#9
REVIEW
Xiaman Wang, Hongli Chen, Ju Bai, Aili He
MicroRNAs (miRNAs) are a general class of endogenous non-coding RNAs with a length of 22 nucleotides, widely existing in diverse species and playing important roles in malignancies initiation and progression. MiRNAs are essential to many in vivo biological processes such as cell proliferation, apoptosis, immune response and tumorigenesis. Significant progress till date has been made in understanding the roles of microRNAs in normal hematopoiesis and hematopoietic malignant diseases. In this review, we summarize the particular signatures of microRNAs in acute myeloid leukemia (AML) patients with specific karyotype and the clinical significance of microRNAs in early diagnosis and treatment...
March 29, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28328180/effect-of-estrogen-on-chick-primordial-follicle-development-and-activation
#10
Dan Zhao, Caifeng Lv, Guang Liu, Yuling Mi, Caiqiao Zhang
Steroid hormones and their receptors play pivotal roles in avian reproduction and development. 17β-estradiol (E2 ) is an essential mediator in ovarian development. In this study, Day 3 (D3) chicks were injected with E2 (0.025, 0.25 or 2.5 mg/kg body weight) for 4 days to assess the effects of estrogen on avian follicle development. Morphological analysis showed that treatment of E2 at 2.5 mg/kg increased the number of growing follicles by 28. 5% and activated follicles by 8.9%, compared with the group. Treatment of E2 also led to increased diameter and area of three kinds of follicles and oocytes, respectively...
March 22, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28328152/microrna-206-regulates-vascular-smooth-muscle-cell-phenotypic-switch-and-vascular-neointimal-formation
#11
Huiyan Sun, Songzhi Cai, Mei Zhang, Juan Zhao, Shuping Wei, Yuyu Luo, Xiangyan Meng, Xin Zhou, Yuming Li, Wencheng Zhang
MiR-206 has been found to play a critical role in skeletal muscle proliferation, differentiation and regeneration. However, little is known about the function of miR-206 in vascular smooth muscle cells (VSMCs) biology. In this study, we will investigate its roles in phenotypic switching of VSMCs and neointimal lesion formation. First, we identified the expression of miR-206 in VSMCs treated with various concentrations of TGFβ1 and in rat carotid arteries after angioplasty by using qPCR. TGFβ1 inhibited the expression of miR-206 and TGFβ1 inhibitor induced miR-206 expression...
March 22, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28328100/smart-mechanosensing-machineries-enable-migration-of-vascular-smooth-muscle-cells-in-atherosclerosis-relevant-3d-matrices
#12
REVIEW
Qingjia Chi, Jieling Shan, Xiaorong Ding, Tieying Yin, Yazhou Wang, Dongyu Jia, Guixue Wang
At the early stage of atherosclerosis, neointima is formed due to the migration of vascular smooth muscle cells (VSMCs) from the media to the intima. VSMCs are surrounded by highly adhesive 3D matrices. They take specific strategies to cross various 3D matrices in the media, including heterogeneous collagen and mechanically-strong basement membrane. Migration of VSMCs is potentially caused by biomechanical mechanism. Most in vitro studies focus on cell migration on 2D substrates in response to biochemical factors...
March 22, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28328082/microrna-488-3p-sensitizes-malignant-melanoma-cells-to-cisplatin-by-targeting-prkdc
#13
Ning Li, Yue Ma, Li Ma, Yu Guan, Liang Ma, Daping Yang
Deregulation of microRNAs (miRNAs) has been implicated in drug resistance in various types of cancers, including malignant melanoma (MM). MiR-488-3p has been reported as a tumor suppressor in several cancers. However, the exact expression patterns of miR-488-3p and the precise molecular mechanisms underlying its role in MM remain largely unknown and require further investigation. In this study, we demonstrated that miR-488-3p is significantly down regulated in MM clinical specimens and cell lines. Ectopic expression of miR-488-3p resulted in markedly increased drug sensitivity of MM cells in vitro and in vivo...
March 22, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28328017/dental-pulp-stem-cells-promote-regeneration-of-damaged-neuron-cells-on-the-cellular-model-of-alzheimer-s-disease
#14
Feixiang Wang, Yali Jia, Jiajing Liu, Jinglei Zhai, Ning Cao, Wen Yue, Huixia He, Xuetao Pei
Alzheimer's disease (AD) is an incurable neurodegenerative disease and many types of stem cells have been used in AD therapy with some favorable effects. In this study, we investigated the potential therapeutical effects of human dental pulp stem cells (hDPSCs) on AD cellular model which established by okadaic acid (OA)-induced damage to human neuroblastoma cell line, SH-SY5Y, in vitro for 24h. After confirmed the AD cellular model, the cells were co-culture with hDPSCs by transwell co-culture system till 24 h for treatment...
March 22, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28318081/silencing-of-atf2-inhibits-growth-of-pancreatic-cancer-cells-and-enhances-sensitivity-to-chemotherapy
#15
Mu Li, Xingda Wu, Ning Liu, Xiaoying Li, Fanbin Meng, Shaowei Song
Pancreatic cancer is one of the leading causes of cancer-related death worldwide. Activating transcription factor 2 (ATF2) is a multifunctional transcription factor, and is implicated in tumor progress, yet its role in pancreatic cancer remains unclear. In the present study, the level of ATF2 in pancreatic cancer tissues and the adjacent non-tumorous tissues was detected by quantitative real-time PCR and western blot. The roles of ATF2 in the proliferation, cell cycle, and apoptosis of pancreatic cancer cells were investigated through ATF2 silencing, and the effect of ATF2 shRNA on the sensitivity of pancreatic cancer cells to gemcitabine, an anti-tumor drug, was explored...
March 20, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28295853/matrine-regulates-th1-th2-cytokine-responses-in-rheumatoid-arthritis-by-attenuating-the-nf-%C3%AE%C2%BAb-signaling
#16
Yaojie Niu, Qiumei Dong, Rongheng Li
To investigate the efficacy and mechanisms of matrine, a component derived from Sophora flavescens in treatment of rheumatoid arthritis (RA), a rat model of RA was established. Compared to control rats, matrine significantly mitigated inflammation and severity of RA (paw volume and articular index (AI) score). Using either mice splenic T cells stimulated with PMA/ionomycin or rat splenic T cells, the levels of Th1 and Th2 responses were determined by flow cytometry, quantitative RT-PCR, and ELISA. Furthermore, the levels of NF-κBp65 (RelA), IκBα, and phosphor-IκBα in T cells were determined by Western blot...
March 15, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28276108/circrna-hsa_circ_0005105-up-regulates-nampt-expression-and-promotes-chondrocyte-extracellular-matrix-degradation-by-sponging-mir-26a
#17
You Wu, Ying Zhang, Yu Zhang, Jia-Jia Wang
Osteoarthritis (OA) is a chronic disease pathologically characterized by articular cartilage degeneration and damage. Currently, studies have found that circular RNA (circRNA) is involved in intracellular RNA regulating network and is closely related to the occurrence and development of diseases, therefore it may become a new biological marker and therapeutic target. After stimulating chondrocytes with interleukin-1 beta (IL-1β), hsa_circ_0005105 expression was significantly upregulated, while miR-26a expression was significantly inhibited...
March 8, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28258707/female-prostate-historical-developmental-and-morphological-perspectives
#18
REVIEW
Manoel Francisco Biancardi, Fernanda Cristina Alcantara Dos Santos, Hernandes Faustino de Carvalho, Bruno Domingos Azevedo Sanches, Sebastião Roberto Taboga
The female prostate was first described by Reijnier de Graaf in 1672, and even after several years this gland is still a matter of controversy. Part of this is because the biological function of this female gland is unclear. Moreover, when compared with the male prostate, the existence of this organ in females does not make sense, mainly when we consider that the major function of this gland is to produce a secretion that is responsible for guarantee the sperm survival and assure the reproductive success. However, even under a controversy field, we now have a lot of scientific information which enhances our knowledge of several important biological aspects of this gland...
March 4, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28244686/androgen-regulation-of-host-defenses-and-response-to-inflammatory-stimuli-in-the-prostate-gland
#19
REVIEW
Amado Alfredo Quintar, Cristina Alicia Maldonado
The prostate gland is a strictly androgen-dependent organ which is also the main target of infectious and inflammatory diseases in the male reproductive tract. Host defenses and immunity of the gland has unique features to maintain a constant balance between response and tolerance to diverse antigens. In this context, the effects of reproductive hormones on the male tract are thus complex and have just started to be defined. From the classical description of "the prostatic antibacterial factor", many host defense proteins with potent microbicidal and anti-tumoral activities have been described in the organ...
February 28, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28244627/impact-of-maternal-and-postnatal-zinc-dietary-status-on-the-prostate-of-pubescent-and-adult-rats
#20
Lucas F Camora, Ana Priscila G Silva, Sérgio A A Santos, Luis A Justulin, Juliana E Perobelli, Luis Fernando Barbisan, Wellerson R Scarano
Zinc is important for cell physiology and alteration of its levels during development can modulate a series of biological events. The aim of this study was to investigate whether dietary zinc deficiency or supplementation during morphogenesis and early postnatal development could interfere in prostate maturation. Pregnant rats were exposed to a standard diet (NZ:35mg Zn/kg chow), low-zinc diet (LZ:3mg of Zn/kg chow) and zinc-supplemented diet (HZ:180mg/Kg chow) from gestational day 10 (GD10) through postnatal day 21 (PND21)...
February 28, 2017: Cell Biology International
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