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Seizure: the Journal of the British Epilepsy Association

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https://www.readbyqxmd.com/read/29156319/large-scale-analysis-of-herpesviridae-in-epilepsy-patients-with-signs-of-autoimmune-encephalitis
#1
Freya Poulheim, Laura Esposito, Christian E Elger, Anna M Eis-Hübinger, Albert J Becker, Pitt Niehusmann
PURPOSE: Epilepsy is one of the most common primary brain disorders. Nonparaneoplastic autoimmune encephalitis is increasingly recognized as an important cause of adult onset epilepsy. However, only in rare cases an initiating factor of the syndrome can be identified. Autoantibody detection after central nervous herpesvirus infection indicates a postviral etiology in a subgroup of patients. In order to analyze a possible underrecognition of postinfectious autoimmunity we performed a large-scale analysis of herpesvirus DNA in cerebrospinal fluid samples from patients with clinical signs of autoimmune encephalitis...
November 17, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29156220/the-epilepsy-phenotype-in-adult-patients-with-intellectual-disability-and-pathogenic-copy-number-variants
#2
Giuseppe d'Orsi, Tommaso Martino, Orazio Palumbo, Maria Grazia Pascarella, Pietro Palumbo, Maria Teresa Di Claudio, Carlo Avolio, Massimo Carella
PURPOSE: To characterize the electroclinical features of epilepsy associated with intellectual disability and pathogenic copy number variations (CNVs) METHODS: we prospectively investigated 61 adult patients with epilepsy and intellectual disability or other neurodevelopmental disorders. We performed high resolution SNP-Array analysis in order to detect clinical relevant chromosomal microdeletions and microduplications. An ordinal logistic regression model was fitted with 34 demographic, clinical and EEG-related variables in order to identify the epilepsy phenotype of patients with pathogenic CNVs...
November 14, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29145060/familial-cerebral-cavernous-malformation-report-of-a-novel-krit1-mutation-in-a-portuguese-family
#3
Inês Rosário Marques, Francisco Antunes, Nadine Ferreira, Miguel Grunho
Cerebral cavernous malformations (CCMs) are vascular malformations which may occur in familial forms which have autosomal dominant inheritance. Mutations have been identified in three genes: KRIT1, MGC4607 and PDCD10. We have documented a novel mutation on KRIT1 gene, and the second to be reported in a Portuguese family. This mutation consists in a two nucleotide insertion (c.947_948insAC) within the exon 10, resulting in premature protein termination (p.Leu317Argfs*2). These findings will hopefully contribute to a better clinical, imaging and genetic characterisation of this disease, particularly while trying to identify the factors that influence its treatment and prognosis...
November 10, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29149669/effective-clinical-classification-of-chronic-epilepsy-into-focal-and-generalized-a-cross-sectional-study
#4
Shambhu Kumar, Mamta Bhushan Singh, Garima Shukla, Sreenivas Vishnubhatla, M V Padma Srivastava, Vinay Goyal, Kameshwar Prasad, Victor Patterson
PURPOSE: Investigations such as EEG and brain imaging are often difficult to obtain in primary care settings of resource-limited regions impacting millions of epilepsy patients. We wanted to test the hypothesis that classification of chronic epilepsy into focal and generalized based on clinical history and examination alone would be comparable to making such a classification with additional inputs from EEG and brain imaging. METHODS: Two investigators independently classified consecutive chronic epilepsy patients into focal, generalized and unclassified epilepsy...
November 9, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29149668/parental-knowledge-and-attitudes-towards-epilepsy-a-study-from-jordan
#5
Amira Masri, Samah Aburahma, Aisha Khasawneh, Abdelkarim Al Qudah, Omar Nafi, Miral Al Momani, Faisal Khatib
PURPOSE: To explore the knowledge, attitudes and behaviors of parents whose children were diagnosed with epilepsy. METHODS: Cross-sectional questionnaire based study of parents who accompanied their children with epilepsy to the child neurology clinics at three university hospitals in Jordan. RESULTS: Most parents (427, 90.3%) knew that epilepsy is not related to a psychiatric disease. Approximately half of the parents (245, 51.8%) used the internet as their source of knowledge, and most used Arabic websites...
November 8, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29132064/patients-and-caregivers-contributions-for-differentiating-epileptic-from-psychogenic-nonepileptic-seizures-value-and-limitations-of-self-reporting-questionnaires-a-pilot-study
#6
Giuseppe Erba, Elisa Bianchi, Giorgia Giussani, John Langfitt, Adam Juersivich, Ettore Beghi
PURPOSE: Questionnaires investigating semiology and comorbidities of psychogenic non-epileptic seizures (PNES) have been used mainly to help physicians expedite referrals to epilepsy centres for confirmation of diagnosis rather than as alternative diagnostic tool when video-EEG monitoring (VEM), the current gold standard, is not available or is inconclusive. METHODS: We developed one structured questionnaire for patients, exploring subjective experiences and vulnerabilities and one for eyewitnesses, focused on features observable during typical events to study prospectively 50 consecutive adult patients with PNES or epileptic seizures (ES) admitted for VEM...
November 8, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29127858/telephonic-review-for-outpatients-with-epilepsy-a-prospective-randomized-parallel-group-study
#7
Kunal Bahrani, Mamta Bhushan Singh, Rohit Bhatia, Kameshwar Prasad, Deepti Vibha, Garima Shukla, Sreenivas Vishnubhatla, Victor Patterson
PURPOSE: Our objective was to assess how telephonic review of outpatients with stable epilepsy compared with conventional face-to-face clinic management. METHODS: We constructed a randomized parallel group study of suitable patients attending our Epilepsy Clinic and compared telephonic review with conventional clinic visit based management. Primary outcomes were the percentage of patients with breakthrough seizures and total number of breakthrough seizures. We also compared cost, patient satisfaction and numbers defaulting...
November 7, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29127859/the-risk-of-subsequent-epilepsy-in-children-with-febrile-seizure-after-5-years-of-age
#8
Pinar Gencpinar, Hamdi Yavuz, Öznur Bozkurt, Şenay Haspolat, Özgür Duman
PURPOSE: Despite their age-dependent definition, febrile seizures (FS) may be observed in people of almost any age. The risk of developing unprovoked seizures after an FS is well defined. However, there are limited data about FS starting or persisting after 5 years of age. In the present study, we evaluated patients who developed FS after 5 years of age. METHOD: Between 2010 and 2014, we prospectively enrolled all patients with FS. We collected demographic and clinical features, radiologic images, electroencephalograms (EEGs), and results of psychomotor development tests and treatment data of the patients...
November 6, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29125946/a-stereo-eeg-study-in-a-patient-with-sleep-related-hypermotor-epilepsy-due-to-depdc5-mutation
#9
Lorenzo Ferri, Francesca Bisulli, Roberto Mai, Laura Licchetta, Chiara Leta, Lino Nobili, Barbara Mostacci, Tommaso Pippucci, Paolo Tinuper
PURPOSE: Dishevelled EGL-10 and pleckstrin domain-containing protein 5 (DEPDC5) mutations are found in a wide spectrum of focal epilepsies ranging from epilepsy caused by malformation of cortical development to non-lesional epilepsy, including sleep-related hypermotor epilepsy (SHE). A surgical approach has been anecdotally reported in patients with DEPDC5 mutations, but most of these cases had a lesional etiology. METHODS: We describe a stereo-EEG (SEEG) study in a patient with drug-resistant/non-lesional SHE...
November 4, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29125945/periodic-eeg-patterns-in-sporadic-creutzfeld-jakob-disease-can-be-benzodiazepine-responsive-and-be-difficult-to-distinguish-from-non-convulsive-status-epilepticus
#10
Justus Marquetand, Susanne Knake, Adam Strzelczyk, Bernhard J Steinhoff, Holger Lerche, Matthis Synofzik, Niels K Focke
PURPOSE: Periodic discharges in EEG and a history of rapidly progressive dementia are known to be associated with sporadic Creutzfeld-Jakob Disease (sCJD). Doubts regarding this rare but fatal diagnosis can arise, when episodic symptoms (seizures, psychiatric features, speech disturbances) are present and the EEG shows epileptiform discharges within this periodicity. This scenario may indicate non-convulsive status epilepticus (NCSE), which is - in contrast to sCJD - a treatable and frequent condition...
November 4, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29102710/how-to-choose-a-practicable-duration-time-for-capturing-paroxysmal-events-by-prolonged-video-electroencephalogram-monitoring-in-the-elderly
#11
Jianhua Chen, Xiangqin Zhou, Yan Huang, Qiang Lu, Liri Jin, Heyang Sun
PURPOSE: To measure association between paroxysmal events and length of monitoring to identify a practicable duration time for capturing seizures in the elderly. METHODS: Consecutive inpatients 60 years and older who were admitted to the Epilepsy Center and underwent prolonged video electroencephalogram (VEEG) monitoring (VEM) were reviewed retrospectively. Electronic medical records were reviewed to collect information regarding sex, age at onset of symptoms and examination, concurrent epilepsy, frequency of seizures, diagnosis before and after examination, antiepileptic drugs (AEDs), brain magnetic resonance imaging (MRI), and VEEG findings...
November 2, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29096164/potential-factors-impacting-health-related-quality-of-life-among-patients-with-epilepsy-results-from-the-united-arab-emirates
#12
Taoufik Alsaadi, Seada Kassie, Khadija El Hammasi, Tarek M Shahrour, Mustafa Shakra, Lamya Turkawi, Wassim Nasreddine, Mufeed Raoof
PURPOSE: to investigate potential factors impacting HRQOL among PWE at a medical facility in the UAE. METHODS: Depression, anxiety, and health-related quality of life were assessed in 160 adult patients with epilepsy from September 2014 to January 2015 at Sheikh Khalifa Medical City (SKMC). The World Health Organization Quality of Life abbreviated scale (WHOQOL-BREF), the Patient Health Questionnaire nine-item (PHQ-9) depression scale, and Generalized Anxiety Disorder seven-item (GAD-7) scale were administered...
October 28, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29125944/hla-a-31-01-and-carbamazepine-induced-dress-syndrom-in-a-sample-of-north-african-population
#13
Kamilia Ksouda, Hanen Affes, Nedia Mahfoudh, Lassad Chtourou, Arwa Kammoun, Aida Charfi, Hend Chaabane, Molka Medhioub, Zouhir Sahnoun, Hamida Turki, Nabil Tahri, Serria Hammami, Khaled Zeghal
PURPOSE: Drug rash with eosinophilia and systemic symptoms (DRESS) is a serious adverse drug reaction. Carbamazepine is the most common causes of this syndrome. The HLA-A*31:01 allele has been shown to be strongly correlated with carbamazepine-induced DRESS syndrome in European, Japanese, Han Chinese and other asian population but not in African populations. So, our purpose is to study there is a correlation between HLA-A*31:01 and carbamazepine-induced DRESS syndrome in africain population? METHODS: HLA class I (A and B) typing was performed on 7 subjects with carbamazepine-DRESS syndrome and 25 tolerants controls subjects...
October 27, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29102709/a-multi-dataset-time-reversal-approach-to-clinical-trial-placebo-response-and-the-relationship-to-natural-variability-in-epilepsy
#14
Daniel M Goldenholz, Alex Strashny, Mark Cook, Robert Moss, William H Theodore
PURPOSE: Clinical epilepsy drug trials have been measuring increasingly high placebo response rates, up to 40%. This study was designed to examine the relationship between the natural variability in epilepsy, and the placebo response seen in trials. We tested the hypothesis that 'reversing' trial direction, with the baseline period as the treatment observation phase, would reveal effects of natural variability. METHOD: Clinical trial simulations were run with time running forward and in reverse...
October 23, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29054498/erratum-to-psychogenic-nonepileptic-seizures-namibian-healthcare-providers-perceptions-and-frustrations-seizure-50-2017-43-52
#15
Anina du Toit, Chrisma Pretorius
No abstract text is available yet for this article.
October 17, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29096163/safety-at-the-william-quarrier-scottish-epilepsy-centre
#16
James Anderson, Victoria Grant, Mariam Elgammal, Alison Campbell, Julia Hampshire, Stig Hansen, Aline J C Russell
PURPOSE: We examined the yield from EMFIT bed alarms and staff response time to generalised seizure in a medium term residential assessment unit for epilepsy. METHODS: The Scottish Epilpesy Centre (SEC) has a Video Observation System (VOS) that provides continuous recording of all patient spaces (external and internal) and allows retention of clinically relevant events. A retrospective audit of daily EMFIT test records, nursing seizure record sheets (seizure type and EMFIT alert status), clinical incident reporting systems and the VOS database of retained clinical events was conducted for an 9 month period from April 1st 2016 till December 31st 2016...
October 16, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29073585/evaluation-of-phenytoin-serum-levels-following-a-loading-dose-in-the-acute-hospital-setting
#17
Olga Selioutski, Katherine Grzesik, Olga N Vasilyeva, Ágúst Hilmarsson, A James Fessler, Lynn Liu, Robert A Gross
PURPOSE: Due to the complex pharmacokinetic profiles of phenytoin (PHT) and fosphenytoin (FOS), achieving sustained, targeted serum PHT levels in the first day of use is challenging. METHODS: A population based approach was used to analyze total serum PHT (tPHT) level within 2-24h of PHT/FOS loading with or without supplementary maintenance or additional loading doses among PHT-naïve patients in the acute hospital setting. Adequate tPHT serum level was defined as ≥20μg/mL...
October 16, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29055272/engaging-psychiatrists-in-the-diagnosis-of-psychogenic-nonepileptic-seizures-what-can-they-contribute
#18
Massimiliano Beghi, Giuseppe Erba, Cesare Maria Cornaggia, Giorgia Giussani, Elisa Bianchi, Gianni Porro, Michela Russo, Ettore Beghi
PURPOSE: To investigate if psychiatrists could predict the diagnosis of psychogenic nonepileptic seizures (PNES) by reviewing videos of seizures of various types and to compare the accuracy and the criteria leading to the diagnosis used by psychiatrists with those used by epileptologists. METHODS: Four board-certified psychiatrists were asked to review 23 videos capturing representative events of 21 unselected consecutive patients admitted to an epilepsy center for long-term video-EEG monitoring...
October 16, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29096165/mri-supersedes-ictal-eeg-when-other-presurgical-data-are-concordant
#19
Yun Jung Hur, Andrew J Kim, Douglas R Nordli
PURPOSE: When ictal EEG is discordant with MRI and other presurgical data, our group has sometimes discounted the ictal findings and proceeded with epilepsy surgical resection based on MRI. We aimed to evaluate the prudence of such practice by comparing the outcome of MRI-lesional epilepsy surgery patients with discordant ictal EEG with those with concordant ictal EEG. METHOD: We retrospectively studied 115 children with epilepsy who underwent surgical resection of an MRI lesion that was corroborated as the epileptogenic focus by other presurgical findings...
October 14, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29040867/long-term-follow-up-of-anterior-thalamic-deep-brain-stimulation-in-epilepsy-a-11-year-single-center-experience
#20
Seong Hoon Kim, Sung Chul Lim, Jiyeon Kim, Byung-Chul Son, Kyung Jin Lee, Young-Min Shon
PURPOSE: Anterior thalamic deep brain stimulation (ATN DBS) is an emerging, effective treatment for patients with drug-resistant epilepsy, but long-term results on its efficacy and safety are lacking. To evaluate the long-term efficacy and safety of ATN DBS treatment, as well as predictors of its success, in patients with drug-refractory epilepsy (DRE). METHOD: We retrospectively studied clinical outcomes in 29 consecutive refractory epilepsy patients treated by a single DBS team (two neurosurgeons, four neurologists) over an 11-year period, for whom follow-up was performed for up to 137 months (mean, 74...
October 14, 2017: Seizure: the Journal of the British Epilepsy Association
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