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Seizure: the Journal of the British Epilepsy Association

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https://www.readbyqxmd.com/read/28926747/ictal-source-imaging-and-electroclinical-correlation-in-self-limited-epilepsy-with-centrotemporal-spikes
#1
Jørgen Alving, Martin Fabricius, Ivana Rosenzweig, Sándor Beniczky
PURPOSE: To elucidate the localization of ictal EEG activity, and correlate it to semiological features in self-limited epilepsy with centrotemporal spikes (formerly called "benign epilepsy with centrotemporal spikes"). METHODS: We have performed ictal electric source imaging, and we analysed electroclinical correlations in three patients with self-limited epilepsy with centrotemporal spikes. RESULTS: The source of the evolving rhythmic ictal activity (9...
September 14, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28917203/cognitive-behavioral-correlates-of-proxy-reports-on-cognitive-capabilities-in-pediatric-patients-with-epilepsy
#2
Christoph Helmstaedter, Renata Vaz Pandolfo, Christian Hoppe, Juri-Alexander Witt
PURPOSE: To validate the Cognitive Problems in Children and Adolescents Questionnaire (KOPKIJ, German: Kognitive Probleme bei Kindern und Jugendlichen), a proxy report measure for recognizing cognitive problems in pediatric patients with epilepsy. METHODS: Anonymized data sets from 279 pediatric epilepsy patients were standardized in regard to the KOPKIJ results of 352 healthy children and adolescents. The KOPKIJ was related to objective routine neuropsychological assessment (NPY), and to two subjective measures, the Child Behavior Checklist questionnaire (CBCL), a proxy rating by the parents, and a questionnaire for self-perceived health-related quality of life in children and adolescents (KINDL)...
September 6, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28910737/chd2-mutations-only-epilepsy-description-of-cognitive-and-behavioral-profile-in-a-case-with-a-new-mutation
#3
Pia Bernardo, Diana Galletta, Felice Iasevoli, Luigi D'Ambrosio, Serena Troisi, Elena Gennaro, Federico Zara, Salvatore Striano, Andrea de Bartolomeis, Antonietta Coppola
No abstract text is available yet for this article.
September 6, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28888215/the-role-of-presurgical-eeg-parameters-and-of-reoperation-for-seizure-outcome-in-temporal-lobe-epilepsy
#4
B Schmeiser, J Zentner, B J Steinhoff, A Brandt, A Schulze-Bonhage, E Kogias, T Hammen
PURPOSE: After surgery for intractable mesiotemporal lobe epilepsy (mTLE) seizures recur in 30-40%. One predictor for seizure recurrence is the distribution of seizure onset and interictal epileptiform discharges (IED). Our study focused on lateralization and extent of epileptiform activity regarding postoperative seizure persistence and the effect of reoperation. METHODS: This study comprises 426 consecutive patients operated for intractable mTLE. Impact of preoperative seizure onset and IED on the persistence of seizures and results of reoperation were analyzed...
September 6, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28910738/burst-suppression-on-eeg-not-always-an-ominous-sign
#5
Egidio Spinelli, Sandra Penney, Sharon Carline, Adam Romanovsky, Syed Nizamuddin Ahmed
No abstract text is available yet for this article.
September 5, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28915401/the-modified-ketogenic-diet-for-adults-with-refractory-epilepsy-an-evaluation-of-a-set-up-service
#6
Kirsty J Martin-McGill, Michael D Jenkinson, Catrin Tudur Smith, Anthony G Marson
PURPOSE: The ketogenic diet (KD) has been proven to be effective in children with refractory epilepsy and is recommended by the National Institute of Health and Care Excellence (NICE). There is no randomised control trial (RCT) evidence for the clinical or cost effectiveness of KD in adults, for whom the KD is not currently recommended. We assessed the feasibility of the modified ketogenic diet (MKD) in adults with refractory epilepsy along with the willingness of patients to participate in a future RCT...
September 1, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28892758/seizure-self-prediction-myth-or-missed-opportunity
#7
REVIEW
Michael Mackay, Hector Mahlaba, Erika Gavillet, Roger G Whittaker
PURPOSE: Many patients report being able to predict their own seizures, and yet most seizures appear to strike out of the blue. This inherent contradiction makes the topic of seizure self-prediction controversial as well as difficult to study. Here we review the evidence for whether this ability exists, how many patients are capable of self-prediction and the nature of this capability, and whether this could provide a target for intervention. METHODS: Systematic searches of bibliographic databases including MEDLINE, EMBASE and PsycINFO through OVID were performed to identify relevant papers which were then screened by the study authors for inclusion in the study...
September 1, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28881259/sodium-channel-blockers-in-kcnq2-encephalopathy-lacosamide-as-a-new-treatment-option
#8
Susanne Schubert-Bast, Peter Hofstetter, Doris Fischer, Rolf Schloesser, Georgia Ramantani, Matthias Kieslich
No abstract text is available yet for this article.
September 1, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28873364/refractory-spasms-of-focal-onset-a-potentially-curable-disease-that-should-lead-to-rapid-surgical-evaluation
#9
Mathilde Chipaux, Georg Dorfmüller, Martine Fohlen, Nathalie Dorison, Marie-Astrid Metten, Olivier Delalande, Sarah Ferrand-Sorbets, Delphine Taussig
PURPOSE: Infantile spasms (IS) can occur as the only seizure type in children with surgically amenable epilepsies. Although early surgery has shown positive effects, little is known regarding outcomes. METHODS: We retrospectively reviewed all children with IS referred to our tertiary center between 2002 and 2014 and try to define factors of outcome. RESULTS: Sixty-eight children with focal onset seizures were referred: twenty children with a hemispheric implication and 48 with one or more lobes involved...
August 31, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28873363/epileptic-seizures-heralding-a-relapse-in-high-grade-gliomas
#10
Carlo Di Bonaventura, Mariarita Albini, Alessandro D'Elia, Jinane Fattouch, Martina Fanella, Alessandra Morano, Giulia Lucignani, Mario Manfredi, Claudio Colonnese, Maurizio Salvati, Nicola Vanacore, Alfredo Berardelli, Anna Teresa Giallonardo
PURPOSE: Seizures are a common clinical symptom in high-grade gliomas (HGG). The aim of the study was to investigate the relationship between seizures and HGG relapse (HGG-R). METHODS: We retrospectively evaluated 145 patients who were surgically treated for HGG-R. By analyzing clinical characteristics in these patients (all operated and treated by the same protocol), we identified 37 patients with seizures during follow-up. This cohort was divided into four subgroups according to a) presence or absence of seizures at the time of diagnosis and b) temporal relationship between seizure occurrence and HGG-R during follow-up: subgroup A (25pts) had seizures at follow-up but not at onset, subgroup B (12pts) had seizures both at follow-up and onset, subgroup C (30pts) had seizures before MRI-documented HGG-R, and subgroup D (7pts) had seizures after MRI-documented HGG-R...
August 24, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28858641/knowledge-and-attitudes-about-epilepsy-a-survey-of-high-school-students-in-germany
#11
Paula Jansen, Martina P Neininger, Matthias K Bernhard, Wieland Kiess, Andreas Merkenschlager, Thilo Bertsche, Astrid Bertsche
PURPOSE: Attitudes concerning epilepsy improved over the last few decades, but children with epilepsy still suffer from stigmatisation. Data about unaffected children's knowledge of and attitudes about epilepsy is scarce. METHODS: We developed a questionnaire regarding epilepsy for high school students attending 8th-10th grade. The survey was performed from October 2015 to March 2016 in 5 different federal states of Germany. RESULTS: 1092 students [mean age (Q25/75): 14...
August 24, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28863398/anti-epileptic-drug-trials-for-patients-with-drug-resistant-idiopathic-generalised-epilepsy-a-meta-analysis
#12
Niamh Colleran, Tom O Connor, Julie Jordan O Brien
PURPOSE: Determine the impact of anti-epileptic drugs (AED) for drug resistant patients with idiopathic generalised epilepsy. METHODS: A systematic search of Medline, Cumulative Index to Nursing an Allied Health Literature (CINAHL), Cochrane Epilepsy Group Central Specialised Register, Cochrane Central Register of controlled Trials (CENTRAL), Embase and Lenus was performed. Nine randomised controlled trials were included. All trials compared antiepileptic drugs to placebo...
August 20, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28843069/new-onset-status-epilepticus-in-older-patients-clinical-characteristics-and-outcome
#13
M P Malter, R D Nass, T Kaluschke, G R Fink, L Burghaus, C Dohmen
PURPOSE: We here evaluated (1) the differential characteristics of status epilepticus (SE) in older (≥60 years) compared to younger adults (18-59 years). In particular, we were interested in (2) the proportion and characteristics of new onset SE in patients with no history of epilepsy (NOSE) in older compared to younger adults, and (3) predictive parameters for clinical outcome in older subjects with NOSE. METHODS: We performed a monocentric retrospective analysis of all adult patients (≥18years) admitted with SE to our tertiary care centre over a period of 10 years (2006-2015) to evaluate clinical characteristics and short-time outcome at discharge...
August 18, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28854405/newer-antiepileptic-drugs-compared-to-levetiracetam-as-adjunctive-treatments-for-uncontrolled-focal-epilepsy-an-indirect-comparison
#14
Li-Na Zhu, Deng Chen, Da Xu, Ge Tan, Hai-Jiao Wang, Ling Liu
PURPOSE: Newer antiepileptic drugs (AEDs), such as Eslicarbazepine (ESL), Lacosamide (LAC), Perampanel (PER) and Brivaracetam (BRV), have been marketed as adjunctive treatments for partial-onset seizures. Our aim was to compare the efficacy and tolerability of newer AEDs with Levetiracetam (LEV), when used as add-on treatments for uncontrolled focal epilepsy. METHOD: We conducted an online database search on PubMed, Embase, Cochrane Online Library and Clinicaltrials...
August 16, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28837898/patterns-of-intrahemispheric-propagation-in-pediatric-photoparoxysmal-response
#15
Tymon Skadorwa, Jolanta Strzelecka
PURPOSE: The photoparoxysmal response (PPR) is the most important EEG indication of photosensitivity (PS). It may be elicited by intermittent photic stimulation (IPS). PS mostly affects young individuals, with adolescent females at greatest risk. The diagnosis of PS is based on visual EEG assessment. To date, no objective test of PS has been established. METHOD: Here we describe 89 individuals of both sexes, aged 5-18 years, epileptic and non-epileptic, in whom a PPR was elicited by IPS during a standard EEG procedure...
August 12, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28826049/lamotrigine-versus-valproic-acid-monotherapy-for-generalised-epilepsy-a-meta-analysis-of-comparative-studies
#16
REVIEW
Linjun Tang, Linbo Ge, Weijun Wu, Xuguang Yang, Pinhe Rui, Yong Wu, Wan Yu, Xi Wang
PURPOSE: The standard for generalized epilepsies (GE) monotherapy in treatment is valproic acid (VPA) and lamotrigine (LTG) has been proposed as an alternative to VPA. This study aimed to evaluate the safety and efficacy of LTG on GE seizure in comparison with VPA. METHOD: A search was conducted based on the databases from Pubmed, Embase and the Cochran database up to February 2017. The relative risk odds ratios (ORs) and the relevant 95% confidence intervals (CI) were determined...
August 12, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28826048/the-role-of-melatonin-to-attain-electroencephalograms-in-children-in-a-sub-saharan-african-setting
#17
Roland Ibekwe, Lata Jeaven, Jo M Wilmshurst
PURPOSE: Limited access to electroencephalograms (EEGs) in sub-Saharan Africa results in a high patient load attending the few neurophysiology units. The state of sleep in children improves yield and reduces artefact of EEGs. Melatonin induces "natural sleep" without the risk of airway compromise. This study evaluated the effectiveness of oral melatonin to attain electroencephalograms in South African children. METHOD: Children undergoing EEG who were unable to cooperate or required sleep EEG, received oral melatonin (3mg<15kg; 6mg>15kg)...
August 12, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28818699/apathy-in-people-with-epilepsy-and-its-clinical-significance-a-case-control-study
#18
Jong-Geun Seo, Gun-Hee Lee, Sung-Pa Park
PURPOSE: Apathy as a state of decreased motivation has not been highlighted in people with epilepsy (PWE). We investigated its clinical significance in PWE. METHODS: We invited adult PWE who had been administered antiepileptic drugs (AEDs) for at least 1year and compared them with age- and gender-matched healthy controls. Eligible participants completed several questionnaires including the Apathy Evaluation Scale-Self (AES-S), the Korean version of the Neurological Disorders Depression Inventory for Epilepsy (K-NDDI-E), the Generalized Anxiety Disorder-7 (GAD-7), the Epworth Sleepiness Scale (ESS), and the Insomnia Severity Index (ISI), and the Quality of Life in Epilepsy-10 (QOLIE-10)...
August 8, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28806589/novel-clinical-manifestations-in-patients-with-kcna2-mutations
#19
Monisha Sachdev, Marina Gaínza-Lein, Dmitry Tchapyjnikov, Yong-Hui Jiang, Tobias Loddenkemper, Mohamad A Mikati
PURPOSE: To report novel clinical manifestations of KCNA2 mutation related epileptic encephalopathy. METHODS: Blood samples were sent for whole exome and Sanger sequencing. Seizure types were characterized by clinical criteria and EEG recording. RESULTS: KCNA2 mutations have been reported in 10 cases who presented with focal, absence, generalized tonic-clonic or myoclonic astatic seizures. Here we describe 3 patients with previously unreported, more severe manifestations...
August 5, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28886496/convulsive-status-epilepticus-in-a-quaternary-hospital-paediatric-intensive-care-unit-picu-in-south-africa-an-8-year-review
#20
Yavini Reddy, Yusentha Balakrishna, Lawrence Mubaiwa
PURPOSE: Convulsive status epilepticus (CSE) is associated with a high morbidity and mortality. This study aimed to describe the clinical profile, aetiology, neuroimaging and EEG findings as well as outcome of children with CSE in Sub-Saharan Africa. METHODS: This was a retrospective analysis of electronic records of children with CSE admitted to the Paediatric Intensive Care Unit (PICU) over an 8-year period from January 2007 to December 2014. RESULTS: Seventy six patients were admitted to the PICU with CSE and 55(72%) had refractory status epilepticus...
August 2, 2017: Seizure: the Journal of the British Epilepsy Association
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