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Seizure: the Journal of the British Epilepsy Association

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https://www.readbyqxmd.com/read/30399460/rising-to-the-challenge-epilepsy-specialist-nurses-as-leaders-of-service-improvements-and-change-sense-study
#1
Agnes Higgins, Carmel Downes, Jarleth Varley, Colin P Doherty, Cecily Begley, Naomi Elliott
PURPOSE: To report the leadership role and change activities of epilepsy specialist nurses (ESNs) in Ireland; findings from the SENsE study. METHOD: A mixed methods study design was used, involving 12 epilepsy specialist nurses working in five units in Ireland, 24multidisciplinary team members working with them, and 35 people with epilepsy and their family members. Data were collected using individual and focus group interviews, observation and documentary analysis...
November 1, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/30408713/visual-field-defects-after-radiosurgery-versus-temporal-lobectomy-for-mesial-temporal-lobe-epilepsy-findings-of-the-rose-trial
#2
Mark Quigg, Nicholas M Barbaro, Mariann M Ward, Edward F Chang, Donna K Broshek, John T Langfitt, Guofen Yan, Kenneth D Laxer, Andrew J Cole, Penny K Sneed, Christopher P Hess, Wei Yu, Steven A Newman, Susanne Mueller, Manjari Tripathi, Christiaanne N Heck, John W Miller, Paul A Garcia, Andrew McEvoy, Nathan B Fountain, Vincenta Salanova, Robert C Knowlton, Anto Bagić, Thomas Henry, Siddharth Kapoor, Guy McKhann, Adriana E Palade, Markus Reuber, Evelyn Tecoma
PURPOSE: Stereotactic radiosurgery (SRS) may be an alternative to anterior temporal lobectomy (ATL) for mesial temporal lobe epilepsy (MTLE). Visual field defects (VFD) occur in 9-100% of patients following open surgery for MTLE. Postoperative VFD after minimally invasive versus open surgery may differ. METHODS: This prospective trial randomized patients with unilateral hippocampal sclerosis and concordant video-EEG findings to SRS versus ATL. Humphries perimetry was obtained at 24 m after surgery...
October 31, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/30391663/progesterone-5a-dihydropogesterone-and-allopregnanolone-s-effects-on-seizures-a-review-of-animal-and-clinical-studies
#3
REVIEW
Yinhao Violet Wu, W McIntyre Burnham
The anti-seizure effects of progesterone family compounds have long been known. Over the years, however, most studies have focused on progesterone and on its secondary metabolite allopregnanolone (ALLO), with less attention being paid to its primary metabolite 5a-dihydroprogesterone (DHP). Here we review animal and clinical studies related to the anti-seizure effects of progesterone and its 5a neuroactive metabolites, including DHP and ALLO. Progesterone and its reduced metabolites all have demonstrated seizure-suppression effects in animal models - except in models of absence seizures - with the common side effects of sedation and ataxia...
October 28, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/30399461/the-first-hour-of-the-day-sleep-eeg-reliably-identifies-interictal-epileptiform-discharges-during-long-term-video-eeg-monitoring
#4
Xi Liu, Naoum P Issa, Sandra Rose, Shasha Wu, Taixin Sun, Leo V Towle, Peter C Warnke, James X Tao
PURPOSE: To determine the usefulness of the first-hour sleep EEG recording in identifying interictal epileptiform discharges (IEDs) during long-term video-EEG monitoring. METHOD: We retrospectively reviewed 255 consecutive patients who underwent continuous long-term video-EEG monitoring in the adult epilepsy monitoring unit (EMU) at the University of Chicago. The complete video-EEG recording was reviewed, and the occurrence of IEDs was determined for each patient...
October 26, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/30396042/seizures-and-recurrence-of-takotsubo-syndrome-one-clinical-presentation-and-trigger-but-two-different-anatomical-variants-in-the-same-patient-a-case-to-meditate-on
#5
G Binaghi, D Congia, S Cossa, R Ganga, G Giardina, G Matta, W Merella, M Melis, D Pasqualucci, E Serra, M Porcu
No abstract text is available yet for this article.
October 26, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/30391662/the-pharmacological-management-of-lennox-gastaut-syndrome-and-critical-literature-review
#6
REVIEW
Alberto Verrotti, Pasquale Striano, Giulia Iapadre, Luca Zagaroli, Paolo Bonanni, Giangennaro Coppola, Maurizio Elia, Oriano Mecarelli, Emilio Franzoni, Paola De Liso, Federico Vigevano, Paolo Curatolo
Lennox-Gastaut syndrome (LGS) is a severe epileptic encephalopathy with a prevalence of 1-2% of all patients with epilepsy. It is characterized by multiple pharmaco-resistant seizure types, including tonic, atypical absences and tonic or atonic drop attacks, and the presence of electroencephalographic abnormalities, such as slow-spike waves and paroxysmal fast rhythms. Intellectual disability, behavioural and psychiatric disorders are common comorbidities; these disturbances have a multi-factorial pathogenesis...
October 26, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/30408712/a-life-with-seizures-argentine-patients-perspectives-about-the-impact-of-drug-resistant-epilepsy-on-their-lives
#7
Mercedes Sarudiansky, Guido Pablo Korman, Laura Scévola, Silvia Oddo, Silvia Kochen, Luciana D'Alessio
PURPOSE: To understand the experience of drug-resistant epilepsy in patients from Argentina, a developing nation. METHOD: A qualitative approach using semi-structured interviews was used to gain an in-depth and contextual understanding of the perspectives of 20 patients with DRE. Data collection and analysis were followed by an inductive and interpretive approach informed by the principles of thematic analysis. RESULTS: Six main themes emerged: 1) Characteristics of the illness, including seizure features -unpredictability, presence of auras, physical and cognitive consequences- and how patients relate with the use of antiepileptic drugs; 2) interactions with health system, regarding the features of the Argentine's health system, and patient's health-seeking behaviours; 3) beliefs about the illness, including psychosocial, biological and folk explanatory models; 4) beliefs about how other people perceive them, which included prejudice, responsibility and overprotection; 5) self-perception, and 6) impact of the illness on their activities...
October 23, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/30391664/ictal-hypoxemia-a-systematic-review-and-meta-analysis
#8
Elisa Bruno, Giulia Maira, Andrea Biondi, Mark P Richardson
PURPOSE: To estimate the incidence of ictal hypoxemia (IH) and to identify clinical and study-related factors modulating the estimate. METHODS: We searched articles recording concurrent peri-ictal and ictal EEG and Sp02 in adults and children with epilepsy. Studies reporting the total number of seizures recorded and the number of seizures with IH were included in a random-effects meta-analysis. A random-effects meta-regression was used to identify variables affecting study heterogeneity...
October 21, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/30385179/imaging-modalities-to-diagnose-and-localize-status-epilepticus
#9
REVIEW
Réjean M Guerriero, William D Gaillard
Neuroimaging, including computed tomography (CT) and magnetic resonance imaging (MRI) are frequently performed in patients who present with status epilepticus (SE). Here we discuss the role of these neuroimaging modalities in clinical evaluation and seizure localization. Additionally, translational neuroimaging research and advanced imaging technologies, such as perfusion and radionucleotide imaging may also contribute to localization of the seizure onset zone and yield opportunities to better understand the pathophysiology of SE and aid in prognostication...
October 21, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/30391661/hyperckemia-associated-with-lacosamide-therapy-in-an-elderly-patient-with-focal-onset-epilepsy
#10
Takashi Matsudaira, Tatsuhiro Terada, Yasukiyo Araki, Hitoshi Ikeda, Tomokazu Obi, Yushi Inoue
No abstract text is available yet for this article.
October 15, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/30340918/paediatric-status-epilepticus-a-series-of-timely-reviews
#11
EDITORIAL
Simon Shorvon
No abstract text is available yet for this article.
October 12, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/30368169/sudep-following-the-second-seizure-in-new-onset-epilepsy-due-to-limbic-encephalitis
#12
Jonas M Hebel, Rainer Surges, Stefan R G Stodieck, Michael Lanz
No abstract text is available yet for this article.
October 10, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/30336400/perineal-stimulation-triggering-seizures-in-a-child-with-dravet-syndrome
#13
Puneet Jain, Pratima Gulati, Daad Alsowat, Miguel A Cortez, O Carter Snead, Robyn Whitney
The reported case demonstrates the clinical and EEG features of an interesting seizure precipitant in a child with Dravet Syndrome. It also showed exacerbation of preexisting epilepsy by mild head injury.
October 9, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/30340162/clinical-characteristics-of-onchocerciasis-associated-epilepsy-in-villages-in-maridi-county-republic-of-south-sudan
#14
Robert Colebunders, Gasim Abd-Elfarag, Jane Y Carter, Peter Claver Olore, Kai Puok, Sonia Menon, Joseph Nelson Fodjo Siewe, Samit Bhattacharyya, Morrish Ojok, Richard Lako, Makoy Yibi Logora
PURPOSE: To describe the clinical manifestations of persons with epilepsy (PWE) in onchocerciasis endemic villages in South Sudan. METHODS: During a survey in Maridi County in May 2018, PWE were interviewed and examined in their households by a clinical officer or medical doctor. Onchocerciasis-associated epilepsy (OAE) was defined as ≥2 seizures without any obvious cause, starting between the ages of 3-18 years in previously healthy persons who had resided for at least 3 years in the onchocerciasis endemic area...
October 5, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/30316048/can-home-videos-made-on-smartphones-complement-video-eeg-in-diagnosing-psychogenic-nonepileptic-seizures
#15
Bhargavi Ramanujam, Deepa Dash, Manjari Tripathi
PURPOSE: To assess the contribution home-videos made on mobile phones can make to the diagnosis of Psychogenic Nonepileptic Seizures (PNES). METHODS: Consecutive patients 10-50 years old, with episodes of altered behavior or abnormal movements, unresponsiveness, or falls, were recruited after they had obtained 'good' or 'fair' quality (quality of video scale (QOV)) home-videos of their episodes on personal mobile phones; these subjects underwent video-electroencephalography (VEEG)...
October 3, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/30308427/efficacy-of-levetiracetam-for-reducing-rolandic-discharges-in-comparison-with-carbamazepine-and-valproate-sodium-in-rolandic-epilepsy
#16
Hideaki Kanemura, Fumikazu Sano, Tetsuo Ohyama, Masao Aihara
PURPOSE: The main purpose of this study was to compare the efficacy of levetiracetam (LEV) with the older antiepileptic drugs (AEDs) for preventing atypical evolution in children with Rolandic epilepsy (RE). Accordingly, the present study compared the efficacy of older AEDs (carbamazepine (CBZ) and valproate sodium (VPA)) with LEV in reducing rolandic discharges (RDs) on interictal electroencephalogram (EEG) in children with RE. METHODS: Patients in this heterogenous study were subdivided into CBZ, VPA and LEV groups in accordance with the initial monotherapy...
October 3, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/30308426/long-term-seizure-outcomes-in-patients-with-drug-resistant-epilepsy
#17
Francesca Conte, Benjamin Legros, Wim Van Paesschen, Andreja Avbersek, Pierandrea Muglia, Chantal Depondt
PURPOSE: Despite the availability of a broad range of treatments for epilepsy, a significant proportion of patients have ongoing seizures. This study aims to characterize the drug resistant population and to report long-term outcomes of patients undergoing different types of pharmacological and surgical treatment. METHODS: Adult patients with drug resistant epilepsy (DRE) were identified from a largely retrospective database of 900 consecutive patients with epilepsy, recruited from two reference centers for DRE in Belgium...
October 1, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/30286410/narrative-analysis-of-written-accounts-about-living-with-epileptic-or-psychogenic-nonepileptic-seizures
#18
Gregg H Rawlings, Ian Brown, Markus Reuber
PURPOSE: This study is based on a narrative analysis of individuals' written accounts of living with epilepsy (n = 29) or psychogenic non-epileptic seizures (n = 20, PNES). Narrative analysis looks at both the content and structure of the personal account. We used a form of narrative analysis that allowed us to identify common story lines, otherwise known as narrative typologies, potentially characteristic of these patient groups. Different narrative typologies were described and compared between writers with the two conditions...
September 28, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/30286409/sulthiame-add-on-therapy-in-children-with-lennox-gastaut-syndrome-a-study-of-44-patients
#19
Roberto H Caraballo, Santiago Flesler, Gabriela Reyes Valenzuela, Sebastian Fortini, Santiago Chacón, Lucas Ross, Daniel Noli
PURPOSE: The aim of this study was to evaluate efficacy and tolerability of sulthiame as an add-on treatment in 44 patients with Lennox-Gastaut syndrome (LGS) refractory to other antiepileptic drugs and/or non-pharmacological treatment. METHODS: Patients were selected according to the following criteria: (1) age 4 years or older, (2) a diagnosis of LGS refractory to at least four previous antiepileptic drugs, alone or in combination. Neurologic examinations, brain magnetic resonance imaging, and repeated prolonged electroencephalography (EEG) or video-EEG studies were performed in all cases...
September 27, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/30296740/long-term-seizure-outcome-in-pediatric-patients-with-focal-cortical-dysplasia-undergoing-tailored-and-standard-surgical-resections
#20
Eva Martinez-Lizana, Susanne Fauser, Armin Brandt, Elisabeth Schuler, Gert Wiegand, Soroush Doostkam, Victoria San Antonio-Arce, Julia Jacobs, Thomas Bast, Mukesch Shah, Josef Zentner, Andreas Schulze-Bonhage
PURPOSE: Focal cortical dysplasia (FCD) is the major cause of focal intractable epilepsy in childhood. Here we analyze the factors influencing the success of surgical treatment in a large cohort of children with histologically ascertained FCD. METHOD: A retrospective study of the effects of FCD type, surgical intervention, and age at surgery in a pediatric cohort. RESULTS: A total of 113 patients (71 male; mean age at surgery 10.3 years; range 0-18) were analyzed; 45 had undergone lesionectomy, 42 lobectomy, 18 multi-lobectomy, and eight hemispherotomy...
September 26, 2018: Seizure: the Journal of the British Epilepsy Association
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