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Seizure: the Journal of the British Epilepsy Association

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https://www.readbyqxmd.com/read/30005300/focal-epilepsy-as-a-late-complication-of-congenital-dacryocystocele
#1
C Silva-Rosas, A Quijada, H Angus-Leppan
No abstract text is available yet for this article.
July 7, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29990708/are-epilepsy-patients-bypassing-primary-care-a-cross-sectional-study-from-india
#2
Shrawan Kumar, Mamta Bhushan Singh, Amit Kumar, Garima Shukla, M V Padma Srivastava, Vinay Goyal, Vishnu V Y
PURPOSE: Lack of epilepsy primary and secondary care and an arbitrary referral system causes many epilepsy patients to seek tertiary care even when they may not need it. This causes overcrowding, increased waiting times and also compromises the quality of tertiary care. We conducted this study to identify what proportion of epilepsy patients presenting to tertiary care actually needed it. METHODS: To test appropriateness of candidacy for tertiary care, we formulated Modified NICE criteria (MNC) based on NICE criteria...
July 4, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29990707/prospective-study-of-the-efficacy-of-a-ketogenic-diet-in-20-patients-with-dravet-syndrome
#3
Ni Yan, Wang Xin-Hua, Zhang Lin-Mei, Chai Yi-Ming, Li Wen-Hui, Zhou Yuan-Feng, Zhou Shui-Zhen
PURPOSE: We evaluated the efficacy and tolerability of the ketogenic diet (KD) on generalised convulsions and status epilepticus (SE) in patients with Dravet syndrome (DS). METHODS: Patients with DS having ≥2 generalised convulsions/month despite drug treatment were included in this study and placed on a KD for 6 months. From 3 months before (baseline) to 6 months after KD initiation, caregivers recorded patients' seizure activity, antiepileptic drug use, and adverse events...
June 30, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29990709/valproate-free-serum-concentrations-more-complex-than-simple-formulas
#4
LETTER
Richard R Riker, David Gagnon, Teresa May, Gilles Fraser, David Seder
No abstract text is available yet for this article.
June 28, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29990706/modulation-of-epileptiform-eeg-discharges-in-patients-with-jme
#5
Kamakshi Dhamija, Neera Chaudhry, Vinod Puri
PURPOSE: To study modulation of epileptiform EEG discharges in patients with JME. METHOD: 50 subjects with JME underwent a sleep deprived EEG recording along with conventional provocative methods and testing with cognitive tasks (CTs). Both categories of tests were evaluated for their effect on occurrence of IEDs. Number of IEDs per unit time was calculated at baseline as well as with each task. Statistical and arbitrary methods were used to assess modulation. By arbitrary method if frequency of IEDs was more than twice that of baseline, it was considered as provocation and if less than half, it was considered as inhibition...
June 28, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29960217/brand-name-to-generic-substitution-of-levetiracetam-in-patients-with-epilepsy
#6
Lee Gha-Hyun, Soo Jung Dae
PURPOSE: Levetiracetam is one of the most widely used antiepileptic drugs, but the evidence related to the safety of substitution from brand name to generic levetiracetam is scarce. The present study evaluated the risk of increased frequency of seizures after replacement of a brand-name levetiracetam with a generic product. METHODS: We enrolled patients with epilepsy who were treated with branded levetiracetam for at least 6 months of sustained use. Patients were advised to switch to the generic levetiracetam...
June 25, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29960852/improving-compliance-in-adults-with-epilepsy-on-a-modified-atkins-diet-a-randomized-trial
#7
Tanya J W McDonald, Bobbie J Henry-Barron, Elizabeth A Felton, Erie G Gutierrez, Joanne Barnett, Rebecca Fisher, MonYi Lwin, Amanda Jan, Diane Vizthum, Eric H Kossoff, Mackenzie C Cervenka
PURPOSE: To determine whether use of a ketogenic formula during the first month of the modified Atkins diet (MAD) in adults with drug-resistant epilepsy (DRE) improves seizure reduction and compliance compared to MAD alone. METHODS: Eighty adults (age ≥18 years) with DRE and ≥4 reliably quantifiable seizures/month were enrolled. All participants were trained to follow a 20 g/day net carbohydrate limit MAD. Patients were randomized to receive one 8-ounce (237 mL) tetrapak of KetoCal® , a 4:1 ketogenic ratio formula, daily in combination with MAD during the first month (treatment arm) or second month (control/cross-over arm)...
June 22, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29957440/a-case-of-de-novo-naa10-mutation-presenting-with-eyelid-myoclonias-aka-jeavons-syndrome
#8
Vinod Valentine, Yoshimi Sogawa, Deepa Rajan, Damara Ortiz
No abstract text is available yet for this article.
June 19, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29940349/transcutaneous-vagal-nerve-stimulatio-t-vns-an-adjunctive-treatment-option-for-refractory-epilepsy
#9
Giuseppina Barbella, Isabella Cocco, Elena Freri, Guia Marotta, Elisa Visani, Silvana Franceschetti, Marina Casazza
PURPOSE: The aim of this trial was to investigate the efficacy and safety of transcutaneous vagal nerve stimulation (t-VNS) in the palliative treatment of drug resistant epileptic patients ineligible for surgery. METHODS: Twenty adult patients received four hours of t-VNS per day for six months (T1), followed by a two-month washout period (T2). The frequency and type of seizures recorded at T1 and T2 were compared with those occurring in the three months preceding study entry (T0)...
June 18, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29933178/theory-of-mind-and-social-competence-in-children-and-adolescents-with-genetic-generalised-epilepsy-gge-relationships-to-epilepsy-severity-and-anti-epileptic-drugs
#10
Elizabeth Stewart, Cathy Catroppa, Deepak Gill, Richard Webster, John Lawson, Anna Mandalis, Mark Sabaz, Belinda Barton, Suncica Lah
PURPOSE: This study aimed to examine Theory of Mind (ToM) and social competence in children and adolescents with genetic generalised epilepsy (GGE), and explore how they relate to neurocognitive and epilepsy variables. METHODS: Twenty-two children and adolescents with GGE (8-16 years old) and 22 typically developing controls completed two behavioural tasks (faux-pas, strange stories) assessing cognitive and affective ToM, and a battery of standardised neuropsychological tests...
June 18, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29933177/seizures-with-migraine-like-attacks-after-radiation-therapy-smart-a-new-meaning-of-an-old-acronym
#11
Edoardo Ferlazzo, Michele Ascoli, Sara Gasparini, Vittoria Cianci, Damiano Branca, Chiara Sueri, Umberto Aguglia
Stroke-like migraine attacks after radiation therapy (SMART) is a late-onset complication of cerebral irradiation, clinically characterized by headache, seizures and focal deficits. We describe two patients with SMART presenting with focal status epilepticus and headache. We believe that SMART is a misnomer that misjudge seizures among clinical features and we suggest to rename this entity as " Seizure with Migraine-like Attacks after Radiation Therapy". The new acronym, modified in its meaning but not in its form (SMART), better reflects the main clinical features and may allow neurologists to recognize this condition more easily...
June 18, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29929109/refractory-epilepsy-in-preschool-children-with-tuberous-sclerosis-complex-early-surgical-treatment-and-outcome
#12
Martine Fohlen, Delphine Taussig, Sarah Ferrand-Sorbets, Mathilde Chipaux, Nathalie Dorison, Olivier Delalande, Georg Dorfmüller
PURPOSE: Epilepsy surgery has been shown to be effective in treating focal epilepsy related to tuberous sclerosis complex (TSC). We analyzed the advantage of early surgical management in terms of seizure frequency and development. METHOD: We retrospectively studied the 15 patients younger than 6 years who underwent resective surgery between 2006 and 2016. Fourteen of them had invasive monitoring while the 15th was operated on under corticography. RESULTS: Epilepsy began before 5 months of age in all patients...
June 18, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29957441/comparison-of-lamotrigine-and-oxcarbazepine-monotherapy-for-pediatric-focal-epilepsy-an-observational-study
#13
Yun Jung Hur
PURPOSE: Oxcarbazepine is known as an effective first-line monotherapy for pediatric focal epilepsy. Lamotrigine has also been reported to have similar efficacy to and better tolerability than carbamazepine. Therefore, the effectiveness of oxcarbazepine and lamotrigine monotherapies was compared in patients with pediatric focal epilepsy. METHOD: A total of 116 patients in pediatric patients with partial epilepsy received lamotrigine (n = 43) or oxcarbazepine (n = 73) monotherapy...
June 15, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29935409/comparison-of-cytokines-and-prooxidants-antioxidants-markers-among-adults-with-refractory-versus-well-controlled-epilepsy-a-cross-sectional-study
#14
Ozlem Ethemoglu, Halil Ay, Ismail Koyuncu, Ataman Gönel
PURPOSE: This study aims to investigate the serum adiponectin, interleukin (IL)-6 and oxidative stress in epilepsy patients who are refractory or non-refractory to treatments. METHOD: The study comprised 31 refractory epilepsy, 29 well-controlled epilepsy patients and control group including 29 healthy individuals. The serum adiponectin, IL-6, total antioxidant status (TAS), total oxidant status levels (TOS) and oxidative stress index (OSİ) were determined. RESULTS: The mean serum adiponectin and TAS levels were significantly lower in the refractory epilepsy patients than in the healty controls, and mean IL-6, TOS and OSİ levels were significantly higher...
June 15, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29929111/calcification-in-cerebral-parenchyma-affects-pharmacoresistant-epilepsy-in-tuberous-sclerosis
#15
Meng-Na Zhang, Li-Ping Zou, Yang-Yang Wang, Ling-Yu Pang, Shu-Fang Ma, Lu-Lu Huang, Yang Gao, Qian Lu, David Neal Franz
PURPOSE: Tuberous sclerosis (TSC) is an autosomal dominant inherited disease caused by mutations in the TSC1 or TSC2 gene and results in the over-activation of the mammalian target of the rapamycin (mTOR) signaling pathway. Rapamycin, an mTOR inhibitor, is clinically used to treat hamartomatous lesionsas in TSC and its effect on controlling epilepsy is also reported in many studies. This study aims to evaluate the risk factors of pharmacoresistant epilepsy in patients with TSC receiving long-term rapamycin treatment...
June 15, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29929112/deletions-of-scn2a-and-scn3a-genes-in-a-patient-with-west-syndrome-and-autistic-spectrum-disorder
#16
Pin Fee Chong, Hirotomo Saitsu, Yasunari Sakai, Toru Imagi, Ryoko Nakamura, Masaru Matsukura, Naomichi Matsumoto, Ryutaro Kira
SCN2A encodes the alpha-subunit of voltage-gated sodium channel, Nav1.2, which is highly expressed at an early stage of the postnatal brain. Genetic studies revealed that de novo heterozygous mutations of SCN2A caused severe developmental disorders in childhood, such as autism and epileptic encephalopathy. However, few reports have demonstrated the cases carrying segmental deletions at the SCN2A locus for those with epileptic disorders. In this study, we report a 1.8-year-old boy, who presented with West syndrome in infancy and developed the sequelae of psychomotor delay and autism...
June 13, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29929108/the-adult-motor-phenotype-of-dravet-syndrome-is-associated-with-mutation-of-the-stxbp1-gene-and-responds-well-to-cannabidiol-treatment
#17
Gary Álvarez Bravo, Antonio Yusta Izquierdo
Dravet syndrome is a terrible disease generally caused by mutations of the SCN1A gene. Recently others genes such as STXBP1 have been involved in the pathogenesis of the disease. The STXBP1 mutation in patients with Dravet Syndrome may additionally causes several parkinsonian features usually attributed to carriers of the SCN1A mutation. Management continues to be difficult that is why Cannabidiol emerged as valid option for treatment of this condition.
June 13, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29908425/comparable-indicators-of-therapeutic-misconception-between-epilepsy-or-parkinson-s-disease-patients-between-those-with-clinical-trial-experience-and-trial-non-participants
#18
Emmi Reijula, Arja Halkoaho, Anna-Maija Pietilä, Tuomas Selander, Kirsti Martikainen, Reetta Kälviäinen, Tapani Keränen
PURPOSE: Study design, personal persuasions, and experiences can influence willingness to participate in clinical trials (CTs). A study assessed differences between Parkinson's disease (PD) or epilepsy patients having participated in CTs and non-participants in knowledge of and attitudes toward CTs. Also considered were factors in willingness to take part and how CT participants experienced the informed consent process. METHOD: Random samples of members of Finland's PD (n = 2000) and epilepsy (n = 1875) patient organisations were posted a questionnaire on their views about CTs...
June 9, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29929110/a-uk-survey-of-the-experience-of-service-provision-for-children-and-young-people-with-epilepsy
#19
Fiona Williams, Aileen McCafferty, Colin Dunkley, Martin Kirkpatrick
PURPOSE: To survey patient and carer experience for children and young people with epilepsy across the United Kingdom. METHODS: We used a Patient Reported Experience Measure methodology to explore perceived satisfaction with their epilepsy service. A survey collected anonymised proxy data on demography and illness severity, and perceptions of interaction with clinicians, ease of access to the service and the quality and quantity of epilepsy information provided...
June 8, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29894917/the-genetic-variant-c588t-of-gabarg2-is-linked-to-childhood-idiopathic-generalized-epilepsy-and-resistance-to-antiepileptic-drugs
#20
Soheir S Abou El Ella, Maha Atef Tawfik, Wafaa Moustafa M Abo El Fotoh, Omar Ahmed M Soliman
PURPOSE: Previous studies have suggested that GABARG2 (Gamma-Aminobutyric acid type A Receptor Gamma 2 subunit) could be a gene of interest in genetic epilepsy; through possible associations with increased epilepsy susceptibility or resistance to antiepileptic drugs. The present study was designed to explore whether the GABARG2 C588 T (rs211037) genetic variant predicts susceptibility to epilepsy and pharmacoresistance among Egyptian children with Idiopathic Generalized Epilepsy (IGE)...
June 6, 2018: Seizure: the Journal of the British Epilepsy Association
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