Marie Juramy, Paolo Cerreia Vioglio, Fabio Ziarelli, Stéphane Viel, Pierre Thureau, Giulia Mollica
Crystallization is fundamental in many domains, and the investigation of the sequence of solid phases produced as a function of crystallization time is thus key to understand and control crystallization processes. Here, we used a solid-state nuclear magnetic resonance strategy to monitor the crystallization process of glycine, which is a model compound in polymorphism, under the influence of crystallizing additives, such as methanol or sodium chloride. More specifically, our strategy is based on a combination of low-temperatures and dynamic nuclear polarization (DNP) to trap and detect transient crystallizing forms, which may be present only in low quantities...
October 23, 2022: Solid State Nuclear Magnetic Resonance