Futaba Inoue, Kenbun Sone, Kohei Kumegawa, Ryuta Hachijo, Eri Suzuki, Saki Tanimoto, Natsumi Tsuboyama, Kosuke Kato, Yusuke Toyohara, Yu Takahashi, Misako Kusakabe, Asako Kukita, Harunori Honjoh, Akira Nishijima, Ayumi Taguchi, Yuichiro Miyamoto, Michihiro Tanikawa, Takayuki Iriyama, Mayuyo Mori, Osamu Wada-Hiraike, Katsutoshi Oda, Hiromu Suzuki, Reo Maruyama, Yutaka Osuga
Histone modification, a major epigenetic mechanism regulating gene expression through chromatin remodeling, introduces dynamic changes in chromatin architecture. Protein arginine methyltransferase 6 (PRMT6) is overexpressed in various types of cancer, including prostate, lung and endometrial cancer (EC). Epigenome regulates the expression of endogenous retrovirus (ERV), which activates interferon signaling related to cancer. The antitumor effects of PRMT6 inhibition and the role of PRMT6 in EC were investigated, using epigenome multi‑omics analysis, including an assay for chromatin immunoprecipitation sequencing (ChIP‑seq) and RNA sequencing (RNA‑seq)...
March 2024: International Journal of Oncology