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International Journal of Oncology

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https://www.readbyqxmd.com/read/28791339/identification-of-novel-genetic-etiology-and-key-molecular-pathways-for-seminoma-via-network-based-studies
#1
Yuanlei Chen, Chao Qi, Liqun Xia, Gonghui Li
Seminoma is the most common testicular malignant germ cell tumor which severely threaten male reproductive health. However, the pathogenesis and progression mechanisms are still unclear and little research is carried out to uncover the mechanism of this cancer. To identify gene signatures that are expected to converge on particular molecular pathways may drive the development of the core cancer characteristics in seminoma. We downloaded the gene expression profiles GSE18155 from GEO database and obtained the differentially expressed genes (DEGs)...
August 4, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28791416/luteolin-induces-apoptotic-cell-death-via-antioxidant-activity-in-human-colon-cancer-cells
#2
Kyoung Ah Kang, Mei Jing Piao, Yea Seong Ryu, Yu Jae Hyun, Jeong Eon Park, Kristina Shilnikova, Ao Xuan Zhen, Hee Kyoung Kang, Young Sang Koh, Yong Joo Jeong, Jin Won Hyun
The present study determined whether luteolin induces HT-29 colon cancer cell death through an antioxidant effect such as the activation of antioxidant enzymes. Luteolin decreased cell viability in human colon cancer cells (HT-29), whereas it had no effect on normal colon cells (FHC). Luteolin induced apoptosis by activating the mitochondria-mediated caspase pathway in HT-29 cells. Luteolin caused loss of the mitochondrial membrane action potential, increased mitochondrial Ca2+ level, upregulated Bax, downregulated Bcl-2, induced the release of cytochrome c from mitochondria to the cytosol, and increased the levels of the active forms of caspase-9 and caspase-3...
August 2, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28791405/silibinin-suppresses-bladder-cancer-cell-malignancy-and-chemoresistance-in-an-nf-%C3%AE%C2%BAb-signal-dependent-and-signal-independent-manner
#3
Yi Sun, Zhenfeng Guan, Wencai Zhao, Yazhuo Jiang, Qing Li, Yongyi Cheng, Yonggang Xu
Because bladder cancer (BCa) is the 9th most common malignant tumor and 13th leading cause of death due to cancer, therapeutic approaches have attracted a great deal of attention from both clinicians and BCa patients. Although the development of surgery and targeted drugs has brought new challenges for the traditional concept of BCa therapy, various types of chemotherapy remain the final treatment method for many BCa patients. However, chemoresistance inevitably appears, leading to the failure of chemotherapy...
August 2, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28791350/prl-3-improves-colorectal-cancer-cell-proliferation-and-invasion-through-il-8-mediated-glycolysis-metabolism
#4
Heyang Xu, Yujie Zeng, Lu Liu, Qian Gao, Shaowen Jin, Qiusheng Lan, Wei Lai, Xingxi Luo, Heng Wu, Yongliang Huang, Zhonghua Chu
Phosphatase of regenerating liver-3 (PRL-3) has been found to be overexpressed in liver metastases of colorectal cancer and rarely expressed in primary tumors, which plays an important role in the metastasis of colorectal cancer cells. Metabolism reprogramming has been found to be a hallmark of cancer cells, and aerobic glycolysis is a metabolic adaption for cancer cells and promotes cell proliferation. However, the association between PRL-3 and glycolysis in colorectal cancer cells is not well understood. In the present study, we explored the association between PRL-3 and glycolysis...
August 2, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28731163/-corrigendum-fuca1-is-induced-by-wild-type-p53-and-expressed-at-different-levels-in-thyroid-cancers-depending-on-p53-status
#5
Nobuo Tsuchida, Masa-Aki Ikeda, Yoshizumu Ishino, Michele Grieco, Giancarlo Vecchio
Subsequent to the publication of the above paper, the authors noted that there was an error on Fig. 4 of page 2046, in which the symbols of α-L-fucosidase 1 (FUCA1) and fucosyltransferase 8 (FUT8) had been mistakenly labelled the wrong way around (FUCA1 should have been represented by the blue bars, and FUT8 by the red). The corrected version of Fig. 4 is shown below, which now accurately shows how average levels of FUCA1 mRNA were low in the anaplastic thyroid cancer samples (ATCs), whereas expression levels in the papillary thyroid cancer samples (PTCs) were comparable, or slightly higher, than those present in normal thyroid tissues...
July 21, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28731124/bmp7-mediates-the-anticancer-effect-of-honokiol-by-upregulating-p53-in-hct116-cells
#6
Rong-Xing Liu, Wen-Yan Ren, Yan Ma, Yun-Peng Liao, Han Wang, Jia-Hui Zhu, Hai-Tao Jiang, Ke Wu, Bai-Cheng He, Wen-Juan Sun
Colorectal cancer (CRC) is the second leading cause of cancer death. Hence, there is a great need to explore new efficacious drugs for the treatment of CRC. Honokiol (HNK), a natural product extracted from magnolia bark, processes various biological activities, including anticancer. In this study, we introduced cell viability assay, western blotting, real-time PCR and immunofluorescent staining to determine the anticancer effect of HNK, and the possible mechanism underlying this biological process. We found that HNK can inhibit the proliferation and induce apoptosis in HCT116 cells in a concentration- and time-dependent manner...
July 21, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28731134/a-novel-gene-expression-scoring-system-for-accurate-diagnosis-of-basaloid-squamous-cell-carcinoma-of-the-esophagus
#7
Takeshi Tada, Reiko Honma, Jun-Ichi Imai, Zenichiro Saze, Michihiko Kogure, Shigeru Marubashi, Kazuhiro Tasaki, Masamitu Unakami, Junji Ezaki, Hirosumi Tamura, Akira Nishikawa, Yuko Hashimoto, Satoshi Waguri, Shinya Watanabe, Mitsukazu Gotoh
Basaloid squamous cell carcinoma of the esophagus (BSCE) is a rare variant of squamous cell carcinoma that is difficult to distinguish from other carcinomas by preoperative endoscopic biopsy because of its histological varieties. Accurate diagnosis is essential for adequate treatment, and the methods proposed so far (e.g., immunohistochemical staining) have limitations. In this study, we tried to identify the characteristic bundles of gene expression in BSCE using comprehensive gene expression analysis (CGEA)...
July 19, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28731125/n-peptide-of-vmip-%C3%A2-reverses-paclitaxel-resistance-by-regulating-mirna-335-in-breast-cancer
#8
Yangyang Wang, Haifeng Wang, Yongxing Ding, Yu Li, Sulian Chen, Lingyu Zhang, Haihua Wu, Jihong Zhou, Kecai Duan, Wenrui Wang, Changjie Chen, Qingling Yang
Acquisition of resistance to paclitaxel is one of the most important problems in treatment of breast cancer patients, but the molecular mechanisms underlying sensitivity to paclitaxel remains elusive. Emerging evidence has demonstrated that microRNAs (miRNAs) play important roles in regulation of cell growth, migration and invasion through inhibiting the expression of its target genes. In our previous studies, we have shown that microRNA-335 (miR‑335) decreased obviously between paclitaxel-resistant (PR) and parental breast cancer cells through miRNA microarray...
July 19, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28731152/aeg-1-associates-with-metastasis-in-papillary-thyroid-cancer-through-upregulation-of-mmp2-9
#9
Lei-Lei Huang, Zhuo Wang, Chuang-Jie Cao, Zun-Fu Ke, Fen Wang, Ran Wang, Can-Qiao Luo, Xiaofang Lu, Lian-Tang Wang
Astrocyte elevated gene-1 (AEG-1), known as an oncogene, is overexpressed in various cancers and implicated in tumor progression and metastasis. However, its functional significance and underlying molecular mechanisms in thyroid cancer remain to be elucidated. In the present study, we detected the potential function of AEG-1 in papillary thyroid cancer (PTC). We also investigated the relation between AEG-1 and matrix metalloproteases (MMP)2 and 9 through immunohistochemistry, western blotting, real-time PCR, immunofluorescence staining, zymography and co-immunoprecipitation (Co-IP)...
July 17, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28713919/ganetespib-induces-g2-m-cell-cycle-arrest-and-apoptosis-in-gastric-cancer-cells-through-targeting-of-receptor-tyrosine-kinase-signaling
#10
Harry Lee, Nipun Saini, Amanda B Parris, Ming Zhao, Xiaohe Yang
Heat shock protein 90 (HSP90) regulates several important cellular processes via its repertoire of 'client proteins'. These client proteins have been found to play fundamental roles in signal transduction, cell proliferation, cell cycle progression and survival, as well as other features of malignant cells, such as invasion, tumor angiogenesis and metastasis. Thus, HSP90 is an emerging target for cancer therapy. To this end, we evaluated ganetespib (STA-9090), a novel and potent HSP90 inhibitor, for its activity in gastric cancer cell lines...
July 13, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28713929/microrna-379-inhibits-metastasis-and-epithelial-mesenchymal-transition-via-targeting-fak-akt-signaling-in-gastric-cancer
#11
Meizhong Xu, Shui Qin, Fan Cao, Shi Ding, Mengnan Li
Accumulating evidence demonstrates that aberrant miRNAs contribute to gastric cancer (GC) development and progression. However, the roles of various miRNAs in GC remain to be determined. In the present study, we confirmed that a reduced miR-379 expression was present in GC tissues and cell lines. Our clinical analysis revealed that the downregulated miR-379 expression was significantly correlated with poor prognostic features including lymph node metastasis and advanced TNM stage. Moreover, we confirmed that miR-379 was a novel independent prognostic marker for predicting 5-year survival of GC patients...
July 12, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28713983/malformin%C3%A2-a1-treatment-alters-invasive-and-oncogenic-phenotypes-of-human-colorectal-cancer-cells-through-stimulation-of-the-p38-signaling-pathway
#12
Sun-Young Park, Hyung-Hoon Oh, Young-Lan Park, Hyung-Min Yu, Dae-Seong Myung, Sung-Bum Cho, Wan-Sik Lee, Daeho Park, Young-Eun Joo
Malformin A1 (MA1), a cyclic pentapeptide isolated from Aspergillus niger, has been found to possess a range of bioactive properties including antibacterial activity. However, it is unclear whether MA1 exerts an anticancer effect or not. In this study, we conducted in vitro experiments to investigate its anticancer properties in human colorectal cancer cells. The effect of MA1 on human colorectal cancer cells, SW480 and DKO1, was examined by the WST-1 cell viability assay, inverted microscopy, 5-bromo-2-deoxyuridine (BrdU) incorporation, flow cytometry, DNA fragmentation, wound healing, Transwell assays, and western blotting...
July 10, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28713941/additive-antitumor-effects-of-celecoxib-and-simvastatin-on-head-and-neck-squamous-cell-carcinoma-in%C3%A2-vitro
#13
Thomas Gehrke, Agmal Scherzad, Stephan Hackenberg, Pascal Ickrath, Philipp Schendzielorz, Rudolf Hagen, Norbert Kleinsasser
Lipid-lowering statins as well as non-steroidal anti-inflammatory drugs (NSAIDs) have been reported to possess cancer-protective effects in many epidemiologic cohort studies. However, the underlying mechanisms of these findings are mostly unknown. To evaluate possible additive antitumor effects of statins and NSAIDs in vitro, PJ-41 and HLaC78 head and neck squamous cell carcinoma cells (HNSCC) were treated with 40 µM celecoxib, 50 µM simvastatin or a combination of both. Analysis of tumor viability, proliferation, apoptosis, cell cycle changes and secretion of interleukin-6 (IL-6) and interleukin-8 (IL-8) was conducted via MTT assay, Annexin V-propidium iodide test, cell cycle analysis, colony assay and enzyme-linked immunosorbent assay (ELISA)...
July 10, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28713968/inhibition-of-proliferation-and-invasion-of-hepatocellular-carcinoma-cells-by-lncrna-aslnc02525-silencing-and-the-mechanism
#14
Zi Chen, Dongwen Xu, Tao Zhang
One of the most differentially expressed long non-coding RNAs (lncRNAs) that we identified by high throughput screening from liver cancer and para-carcinoma tissues, ASLNC02525, was highly expressed in the tissues and cell lines of liver cancer but not in adjacent tissues or normal hepatic cells. Knockdown of ASLNC02525 in hepatocellular carcinoma cells inhibited the proliferation and invasion. In the process, expression level of transcription factor twist1 (twist‑related protein 1) was reduced, but no change at transcription level was observed...
July 7, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28713989/effects-of-proton-beam-irradiation-on-mitochondrial-biogenesis-in-a-human-colorectal-adenocarcinoma-cell-line
#15
Byung Geun Ha, Sung Suk Jung, Yun Hee Shon
Proton beam therapy has recently been used to improve local control of tumor growth and reduce side-effects by decreasing the global dose to normal tissue. However, the regulatory mechanisms underlying the physiological role of proton beam radiation are not well understood, and many studies are still being conducted regarding these mechanisms. To determine the effects of proton beams on mitochondrial biogenesis, we investigated: mitochondrial DNA (mtDNA) mass; the gene expression of mitochondrial transcription factors, functional regulators, and dynamic-related regulators; and the phosphorylation of the signaling molecules that participate in mitochondrial biogenesis...
July 5, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28713969/downregulation-of-ptprh-sap-1-in-colorectal-tumors
#16
Mateusz Bujko, Paulina Kober, Małgorzata Statkiewicz, Michal Mikula, Emilia Grecka, Nataliia Rusetska, Marcin Ligaj, Jerzy Ostrowski, Janusz Aleksander Siedlecki
Tyrosine phosphorylation is one of the basic mechanisms for signal transduction in the cell. Receptors exhibiting tyrosine kinase activity are widely involved in carcinogenesis and are negatively regulated by receptor protein tyrosine phosphatases (RPTP). Genes encoding different RPTPs are affected by aberrant epigenetic regulation in cancer. PTPRH (SAP-1) has been previously described to be overexpressed in colorectal cancer (CRC) and classified as an oncogenic factor. Previous microarray-based mRNA expression comparison of colorectal adenomas (AD), CRC and normal mucosa samples (NM) demonstrated that PTPRH tumor expression is the most reduced of all RPTP genes...
July 5, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28677801/modulation-of-igf2bp1-by-long-non-coding-rna-hcg11-suppresses-apoptosis-of-hepatocellular-carcinoma-cells-via-mapk-signaling-transduction
#17
Yantian Xu, Yuanwen Zheng, Hongyan Liu, Tao Li
Hepatocellular carcinoma (HCC) is a common malignancy of the liver. HCG11 is a member of long non‑coding family, upregulation of which in HCC was proved by our previous study. In the present study, the role of HCG11 in the development of HCC was detected by focusing on the interaction between HCG11 and its target protein insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1). The expression status of HCG11 and IGF2BP1 was first investigated with clinical HCC samples. Then the expressions of HCG11 and IGF2BP1 were both inhibited in the human HCC cell line HepG2 and the cell viability, proliferation, apoptosis and metastasis potential of HepG2 cells were assessed...
July 5, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28677745/galectin-1-is-a-diagnostic-marker-involved-in-thyroid-cancer-progression
#18
Vanessa Arcolia, Fabrice Journe, Aurore Wattier, Emmanuelle Leteurtre, Florence Renaud, Hans-Joachim Gabius, Myriam Remmelink, Christine Decaestecker, Alexandra Rodriguez, Sébastien Boutry, Sophie Laurent, Sven Saussez
Fine-needle aspiration (FNA) is the most commonly used pre-operative technique for diagnosis of malignant thyroid tumor. However, many benign lesions, with indeterminate diagnosis following FNA, are referred to surgery. Based on multifunctionality of the endogenous galectin-1, we aimed to assess its status for early diagnosis of thyroid cancer. Immunohistochemistry for galectin-1 and -3 was performed on a clinical series of 69 cases of thyroid lesions. Galectin-1 expression was further examined in two additional tissue microarrays (TMA) composed of 66 follicular adenomas and 66 papillary carcinomas in comparison to galectin-3 and cytokeratin-19 (CK19)...
July 4, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28677721/zinc-finger-protein-545-is-inactivated-due-to-promoter-methylation-and-functions-as-a-tumor-suppressor-through-the-wnt-%C3%AE-catenin-pi3k-akt-and-mapk-erk-signaling-pathways-in-colorectal-cancer
#19
Shili Xiang, Tingxiu Xiang, Qian Xiao, Yunhai Li, Bianfei Shao, Tao Luo
The transcription factor, zinc-finger protein 545 (ZNF545), that belongs to the Kruppel-associated box zinc-finger protein (KRAB-ZFP) family, acts as a tumor suppressor and is inactivated by promoter methylation in cancers such as nasopharyngeal carcinoma, breast cancer, and gastric cancer, but its role in colorectal cancer (CRC) is unknown. The purpose of this study was to characterize the ZNF545 expression, methylation status, biological function, and related molecular mechanisms in CRC. The results showed that ZNF545 was expressed in adult normal colorectal tissues, but downregulated or silenced in CRC cell lines, and this mechanism was reversed by demethylation treatment with 5-aza-2'-deoxycytidine and trichostatin A...
July 4, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28677808/a-novel-engineered-interferon-%C3%AE-hybrid-molecule-increases-anticancer-efficacy-of-doxorubicin-in-breast-cancer-chemotherapy
#20
Si-Jie Li, Chun-Shui Liu, Hai-Jun Li, Yan Li, Lei Zhou, Jin-Cheng Li, Yi-Chang Chen, Tian-Qi Su, De-Hai Yu
Breast cancer is the most common carcinoma among Chinese women. Interferon α (IFNα) has been used to treat various types of cancer, including breast cancer, but its antitumor activity is relative low, which significantly hinders its clinical application. In this study, we utilized a Ph.D.-12 peptide library screening system to identify a short peptide that specifically binds to MCF-7 breast cancer cells. By fusing the MCF-7 binding peptide (MBP) to the C-terminus of IFNα, we constructed an engineered IFNα-MBP fusion molecule (IMBP), and applied this novel fusion protein to the treatment of breast cancer...
July 3, 2017: International Journal of Oncology
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