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International Journal of Oncology

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https://www.readbyqxmd.com/read/30221674/prognostic-value-and-potential-function-of-splicing-events-in-prostate-adenocarcinoma
#1
Zhi-Guang Huang, Rong-Quan He, Zeng-Nan Mo
Prostate adenocarcinoma (PRAD) is one of the most common types of malignancy in males and at present, effective prognostic indicators are limited. The development of PRAD has been associated with abnormalities in alternative splicing (AS), a requisite biological process of gene expression in eukaryotic cells; however, the prognostic value of AS products and splicing events remains to be elucidated. In the present study, the data of splicing events and the clinical information of PRAD patients were obtained from The Cancer Genome Atlas (TCGA)SpliceSeq and TCGA databases, respectively...
September 17, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30221676/lipocalin-2-inversely-regulates-trail-sensitivity-through-p38-mapk-mediated-dr5-regulation-in-colorectal-cancer
#2
Se-Lim Kim, In Suk Min, Young Ran Park, Soo Teik Lee, Sang-Wook Kim
TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis through death receptors (DRs)4 and/or 5 expressed on the cell surface. Multiple clinical trials are underway to evaluate the antitumor activity of recombinant human TRAIL and agonistic antibodies to DR4 or DR5. However, their therapeutic potential is limited by the high frequency of cancer resistance. In this study, we provide evidence demonstrating the role of lipocalin 2 (LCN2) in the TRAIL-mediated apoptosis of human colorectal cancer (CRC)...
September 14, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30221742/novel-sirt1-inhibitor-15-deoxy-%C3%AE-12-14-prostaglandin-j2-and-its-derivatives-exhibit-anticancer-activity-through-apoptotic-or-autophagic-cell-death-pathways-in-skov3-cells
#3
In Hwan Tae, Eun Young Park, Prasanta Dey, Ji Yeon Son, Seok-Yong Lee, Jee H Jung, Saloni Saloni, Mi-Hyun Kim, Hyung Sik Kim
Clinically relevant sirtuin (SIRT) inhibitors may possess antitumor activities. A previous study indicated that 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) exhibited potent anticancer activity by SIRT1 inhibition. Therefore, the aim of the present study was to investigate whether its derivatives (J11-C1 and J19) exhibited anticancer activity against ovarian cancer SKOV3 cells. Cell viability was determined using an MTT assay. Cell cycle arrest, apoptosis and autophagy were determined using flow cytometry or western blot analysis...
September 13, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30221677/establishment-of-a-non%C3%A2-coding-rnaomics-screening-platform-for-the-regulation-of-kras-in-pancreatic-cancer-by-rna-sequencing
#4
Li Zhang, Shuangni Yu, Cuiping Wang, Congwei Jia, Zhaohui Lu, Jie Chen
KRAS oncogene point mutations occur in >95% of patients with pancreatic cancer. The KRAS protein can activate various downstream effector molecules that affect proliferation and differentiation. MS2 binding sites (MS2bs) are RNAs of 19 bp in length that can bind MS2 coat proteins with their specific stem-loop structure. The MS2 binding site sequence of the 19-nucleotide stem-loop is ACATGAGGATCACCCATGT. We constructed an expression vector that expresses the KRAS non‑coding region coupled with 12 copies of MS2bs in series and established a high-throughput library for collecting microRNA (miRNA or miR)- and long non‑coding RNA (lncRNA)-omics that regulate KRAS...
September 13, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30221693/high-expression-of-copine-1-promotes-cell-growth-and-metastasis-in-human-lung-adenocarcinoma
#5
Shunlin Liu, Haicheng Tang, Jianjie Zhu, Heguo Ding, Yuanyuan Zeng, Wenwen Du, Zongli Ding, Pengtao Song, Yang Zhang, Zeyi Liu, Jian-An Huang
Despite advances in diagnosis and treatment, the survival of non-small cell lung cancer (NSCLC) patients is poor. Further understanding of the disease mechanism and treatment strategies is required. Copines are a family of calcium-dependent phospholipid-binding proteins that are evolutionally conserved in various eukaryotic organisms and protists. Copine 1, encoded by CPNE1, is a soluble membrane-binding protein, which includes two tandem C2 domains at the N-terminus and an A domain at the C‑terminus. A previous study reported that Copine 1 binds with various intracellular proteins via its A domain and C  omain...
September 12, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30221691/photothermal-therapy-with-aunrs-and-egfrmab-aunrs-inhibits-subcutaneous-transplantable-hypopharyngeal-tumors-in-nude-mice
#6
Yingying Zhang, Jiayan He, Yu Wang, Jinya Wen, Yingying Zou, Zhihong Yang, Xiaoguang He
The present study aimed to investigate the effects of photothermal therapy with gold nanorods (AuNRs) or epidermal growth factor receptor monoclonal antibody‑conjugated AuNRs (EGFRmAb‑AuNRs) on hypopharyngeal carcinoma (HC) in nude mice. In addition, the associated signaling pathways were explored. Briefly, a subcutaneous transplantable hypopharyngeal tumor model was established in nude mice injected with FaDu human HC cells. A total of 70 nude mice were randomly divided into seven groups, each of which received a different treatment...
September 12, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30221675/y-box-binding-protein-1-and-stat3-independently-regulate-atp-binding-cassette-transporters-in-the-chemoresistance-of-gastric-cancer-cells
#7
Pei Jou Chua, Jia Pei Lim, Tian Tian Guo, Puja Khanna, Qidong Hu, Boon Huat Bay, Gyeong Hun Baeg
Y-box binding protein-1 (YB-1) facilitates cancer chemoresistance through the upregulation of ATP-binding cassette (ABC) transporters associated with multidrug resistance, which is one of the primary obstacles in cancer treatment. Since aberrant Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling is also implicated in chemoresistance in numerous human malignancies, the interaction between YB-1 and JAK/STAT signaling was explored underlying the chemoresistance of NUGC3 gastric cancer cells...
September 11, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30132520/col1a1-a-potential-therapeutic-target-for-colorectal-cancer-expressing-wild-type-or-mutant-kras
#8
Zheying Zhang, Cheng Fang, Yongxia Wang, Jinghang Zhang, Jian Yu, Yongxi Zhang, Xianwei Wang, Jiateng Zhong
Colorectal cancer (CRC) treatment primarily relies on chemotherapy along with surgery, radiotherapy and, more recently, targeted therapy at the late stages. However, chemotherapeutic drugs have high cytotoxicity, and the similarity between the effects of these drugs on cancerous and healthy cells limits their wider use in clinical settings. Targeted monoclonal antibody treatment may compensate for this deficiency. Epidermal growth factor receptor (EGFR)‑targeted drugs have a positive effect on CRC with intact KRAS proto-oncogene GTPase (KRAS or KRASWT), but may be ineffective or harmful in patients with KRAS mutations (KRASMUT)...
August 22, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30132516/arhgef7-promotes-metastasis-of-colorectal-adenocarcinoma-by-regulating-the-motility-of-cancer-cells
#9
Xiong Lei, Li Deng, Dongning Liu, Shijun Liao, Hua Dai, Jiaxi Li, Jun Rong, Zhiwen Wang, Guodong Huang, Cheng Tang, Chen Xu, Benping Xiao, Taiyuan Li
Previous studies have shown that Rho guanine nucleotide exchange factor 7 (ARHGEF7) is implicated in cytoskeleton remodelling, which is important for cell motility and invasiveness, and exhibits frequent high-level genetic amplification in metastatic lesions of colorectal adenocarcinoma. Therefore, it was hypothesized that ARHGEF7 may be involved in the metastasis of colorectal adenocarcinoma. In the present study, it was demonstrated that the expression level of ARHGEF7 was significantly upregulated in colorectal adenocarcinoma tumor tissues compared with matched nontumorous tissues, and its expression level correlated with colorectal adenocarcinoma metastasis...
August 22, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30132510/microrna%C3%A2-143-increases-cell-apoptosis-in-myelodysplastic-syndrome-through-the-fas-fasl-pathway-both-in-vitro-and-in-vivo
#10
Jiaqi Cui, Chunmei Wei, Linli Deng, Xingyi Kuang, Zengtie Zhang, Chryso Pierides, Jianxiang Chi, Li Wang
Whilst the role of microRNA‑143 (miR‑143) in myelodysplastic syndrome (MDS) remains unclear, abnormally expressed microRNA‑143 has been detected in many types of cancer tissues. In this study, we describe a cohort study for the verification of miR‑143 expression, as well as the investigation of the molecular mechanisms of miR‑143 in MDS/acute myeloid leukaemia (AML). In a series of experiments, miR‑143 recombinant lentiviral vectors transformed into SKM‑1 cells were either overexpressed or knocked down, and the results illustrated that the overexpression of miR‑143 inhibited SKM‑1 cell growth, arrested the SKM‑1 cells in the G0/G1 phase, interfered with cell proliferation and induced cell apoptosis via the Fas/FasL pathway...
August 22, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30132526/microrna-1254-exerts-oncogenic-effects-by-directly-targeting-rassf9-in-human-breast-cancer
#11
Bin Li, Peng Chen, Jialin Wang, Linxia Wang, Mingzhi Ren, Ruisan Zhang, Jianjun He
MicroRNAs (miRNAs or miRs) play crucial roles in human breast cancer. Although miR-1254 has been shown to have oncogenic activity in several cancer types, its biological function in breast cancer and its mechanisms of action remain unclear. In this study, we investigated the role of miR-1254 in human breast cancer and sought to elucidate the relevant underlying mechanisms. We found that miR-1254 expression was markedly increased in breast cancer tissues and cell lines. Additionally, miR-1254 overexpression accelerated breast cancer cell proliferation, cell cycle G1-S phase transition and inhibited apoptosis...
August 21, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30132517/dna-topoisomerase-1-and-2a-function-as-oncogenes-in-liver-cancer-and-may-be-direct-targets-of-nitidine-chloride
#12
Li-Min Liu, Dan-Dan Xiong, Peng Lin, Hong Yang, Yi-Wu Dang, Gang Chen
The aim of the present study was to determine the role of topoisomerase 1 (TOP1) and topoisomerase 2A (TOP2A) in liver cancer (LC), and to investigate the inhibitory effect of nitidine chloride (NC) on these two topoisomerases. Immunohistochemistry (IHC) staining and microarray or RNA sequencing data mining showed markedly higher expression of TOP1 and TOP2A at the protein and mRNA levels in LC tissues compared with that in control non-tumor tissues. The prognostic values of TOP1 and TOP2A expression were also estimated based on data from The Cancer Genome Atlas...
August 21, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30132512/%C3%AE-catenin-decreases-acquired-trail-resistance-in-non-small-cell-lung-cancer-cells-by-regulating-the-redistribution-of-death-receptors
#13
Chengcheng You, Shimin Zhang, Yingming Sun, Shiyu Zhang, Guiliang Tang, Fang Tang, Xuefeng Liu, Yu Xiao, Junhong Zhang, Yan Gong, Conghua Xie
Tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) exhibits antitumor activity in various types of tumor cell and tumor‑bearing animals. However, acquired TRAIL resistance is a common issue that restricts its clinical application. Previous studies have revealed that β‑catenin is associated with TRAIL resistance in melanoma and colorectal tumors. In the present study, an acquired‑resistance non‑small‑cell lung cancer (NSCLC) cell line (H460‑TR) was established from parental TRAIL‑sensitive H460 cells using a gradient ascent model (8‑256 ng/ml TRAIL)...
August 21, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30132509/resveratrol-promotes-the-sensitivity-of-small-cell-lung-cancer-h446-cells-to-cisplatin-by-regulating-intrinsic-apoptosis
#14
Wangping Li, Yun Shi, Ruixuan Wang, Lei Pan, Lijie Ma, Faguang Jin
The aim of the present study was to evaluate the effects of resveratrol on small-cell lung cancer (SCLC) cell proliferation and apoptosis. The results demonstrated that resveratrol concentration- and time-dependently reduced H446 cell viability. In addition, cells treated with resveratrol displayed higher apoptotic rates, in association with mitochondrial depolarization, cytochrome c release from the mitochondrial compartment to the cytoplasm, apoptosis-inducing factor translocation from the mitochondrial compartment to the nucleus, and altered protein levels of Bcl-2, Bcl-xL and Bax...
August 21, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30132507/serum-mir-30d-as-a-novel-biomarker-for-multiple-myeloma-and-its-antitumor-role-in-u266-cells-through-the-targeting-of-the-mtdh-pi3k-akt-signaling-pathway
#15
Bingying Zhu, Hongmei Chen, Xiaofen Zhang, Yafang Pan, Rongrong Jing, Lei Shen, Xudong Wang, Shaoqing Ju, Chunjing Jin, Hui Cong
Multiple myeloma (MM) is a hematological tumor and is characterized by the infiltration of malignant clonal plasma cells (PCs) in bone marrow. MicroRNAs (miRNAs or miRs) have been reported to play an important role in the genesis and progression of MM. However, little is known about the clinical diagnostic value and biological functions of miR-30d in MM. In this study, to investigate the role of miR-30d in MM, we used reverse transcription-quantitative polymerase chain reaction quantitative (RT-qPCR) to detect the relative expression level of miR-30d in the serum of 81 patients with primary MM and 78 healthy donors (HDs)...
August 21, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30132519/inhibition-of-pi3k-signalling-increases-the-efficiency-of-radiotherapy-in-glioblastoma-cells
#16
Sebastian Hasslacher, Lukas Schneele, Sebastien Stroh, Julia Langhans, Katharina Zeiler, Patricia Kattner, Georg Karpel-Massler, Markus D Siegelin, Matthias Schneider, Shaoxia Zhou, Michael Grunert, Marc-Eric Halatsch, Lisa Nonnenmacher, Klaus-Michael Debatin, Mike-Andrew Westhoff
Glioblastoma, the most common primary brain tumour, is also considered one of the most lethal cancers per se. It is highly refractory to therapeutic intervention, as highlighted by the mean patient survival of only 15 months, despite an aggressive treatment approach, consisting of maximal safe surgical resection, followed by radio- and chemotherapy. Radiotherapy, in particular, can have effects on the surviving fractions of tumour cells, which are considered adverse to the desired clinical outcome: It can induce increased cellular proliferation, as well as enhanced invasion...
August 16, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30132514/anticancer-effects-of-oridonin-on-colon-cancer-are-mediated-via-bmp7-p38-mapk-p53-signaling
#17
Rong-Xing Liu, Yan Ma, Xue-Lian Hu, Wen-Yan Ren, Yun-Peng Liao, Han Wang, Jia-Hui Zhu, Ke Wu, Bai-Cheng He, Wen-Juan Sun
Colon cancer is a prevalent malignancy affecting the gastrointestinal tract. Oridonin (ORI) is a promising chemotherapeutic drug used in the treatment of colon cancer. In this study, we examined the anticancer activity of ORI against colon cancer and elucidated the underlying molecular mechanisms. Cell counting kit-8, flow cytometric and western blot analyses were conducted to analyze the growth inhibitory effects of ORI on SW620 cells; we employed BMP7 and p53 recombinant adenovirus to detect the influence of ORI on the p38 MAPK signal pathway; PT-qPCR, cell immunofluorescence staining and western blot analysis were used to detect the expression of BMP7, p38 and p-p38, p53 and p-p53...
August 16, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30132513/knockdown-of-anti-silencing-function-1b-histone-chaperone-induces-cell-apoptosis-via-repressing-pi3k-akt-pathway-in-prostate-cancer
#18
Guangye Han, Xinjun Zhang, Pei Liu, Quanfeng Yu, Zeyu Li, Qinnan Yu, Xiaoxia Wei
Prostate cancer (PCa) is one of the most common malignancies among males worldwide. Anti-silencing function 1B histone chaperone (ASF1B) has been reported to be involved in PCa. The present study aimed to investigate the role and molecular mechanism of ASF1B in PCa. Data of genes were obtained from The Cancer Genome Atlas database. The core gene was identified using the DAVID website. Cell viability and colony formation were detected using a cell counting kit-8 assay and crystal violet staining, respectively...
August 16, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30106140/lncrna-linc00673-induces-proliferation-metastasis-and-epithelial-mesenchymal-transition-in-thyroid-carcinoma-via-kruppel-like-factor-2
#19
Erjie Xia, Adheesh Bhandari, Yanyan Shen, Xiaofen Zhou, Ouchen Wang
The incidence of thyroid cancer has increased in the past decades; however, the underlying molecular mechanisms of thyroid cancer tumorigenesis remain unknown. Using sequencing technology, long intergenic non‑protein coding RNA 673 (LINC00673) was identified to be upregulated in several tumor tissues. However, the biological role of LINC00673 in thyroid carcinoma has yet to be determined. In this study, 60 matched pairs of thyroid tumor tissue and normal tissue were selected for study using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) to validate previous findings; then, clinicopathologic features of the tissues were analyzed...
August 14, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30106130/human-non%C3%A2-small-cell-lung-cancer-cells-can-be-sensitized-to-camptothecin-by-modulating-autophagy
#20
Yi-Han Chiu, Shih-Hsien Hsu, Hsiao-Wei Hsu, Kuo-Chin Huang, Wangta Liu, Chang-Yi Wu, Wei-Pang Huang, Jeff Yi-Fu Chen, Bing-Hung Chen, Chien-Chih Chiu
Lung cancer is a prevalent disease and is one of the leading causes of mortality worldwide. Despite the development of various anticancer drugs, the prognosis of lung cancer is relatively poor. Metastasis of lung cancer, as well as chemoresistance, is associated with a high mortality rate for patients with lung cancer. Camptothecin (CPT) is a well-known anticancer drug, which causes cancer cell apoptosis via the induction of DNA damage; however, the cytotoxicity of CPT easily reaches a plateau at a relatively high dose in lung cancer cells, thus limiting its efficacy...
August 14, 2018: International Journal of Oncology
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