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International Journal of Oncology

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https://www.readbyqxmd.com/read/28393241/tgf-%C3%AE-1-induces-hmga1-expression-the-role-of-hmga1-in-thyroid-cancer-proliferation-and-invasion
#1
Jing Zhong, Chang Liu, Qing-Hai Zhang, Ling Chen, Ying-Ying Shen, Ya-Jun Chen, Xi Zeng, Xu-Yu Zu, Ren-Xian Cao
The role of transforming growth factor-β1 (TGF-β1) is complicated and plays a different role in the development of cancer. High mobility group A (HMGA1) participates in multiple cellular biology processes, and exerts important roles in the epithelial-mesenchymal transition (EMT). However, the correlation of TGF-β1 and HMGA1 in cancer cells is not yet fully understood. In this study, we determined the effects of TGF-β1 on HMGA1 expression in thyroid cancer cells and examined the role of HMGA1 in thyroid cancer progression...
April 7, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28393238/modulation-of-interactions-of-neuroblastoma-cell-lines-with-extracellular-matrix-proteins-affects-their-sensitivity-to-treatment-with-the-anti-gd2-ganglioside-antibody-14g2a
#2
Irena Horwacik, Hanna Rokita
Children diagnosed with high risk neuroblastoma have poor prognosis which stimulates efforts to broaden therapies of the neoplasm. GD2-ganglioside (GD2) marks neuroblastoma cells and is a target for monoclonal antibodies. We have recently shown that some neuroblastoma cell lines are sensitive to direct cytotoxicity of the anti-GD2 mouse monoclonal antibody 14G2a (mAb). For IMR-32 and LA-N-1 cell lines, treatment with the 14G2a mAb induced evident changes in appearance such as cell rounding, aggregation, loose contact with culture plastic, or detachment...
April 7, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28393180/fenofibrate-inhibits-tumour-intravasation-by-several-independent-mechanisms-in-a-3-dimensional-co-culture-model
#3
Chi Huu Nguyen, Nicole Huttary, Atanas G Atanasov, Waranya Chatuphonprasert, Stefan Brenner, Adryan Fristiohady, Junli Hong, Serena Stadler, Silvio Holzner, Daniela Milovanovic, Verena M Dirsch, Brigitte Kopp, Philipp Saiko, Liselotte Krenn, Walter Jäger, Georg Krupitza
Lymph node metastasis of breast cancer is a clinical marker of poor prognosis. Yet, there exist no therapies targeting mechanisms of intravasation into lymphatics. Herein we report on an effect of the antidyslipidemic drug fenofibrate with vasoprotective activity, which attenuates breast cancer intravasation in vitro, and describe the potential mechanisms. To measure intravasation in a 3-dimensional co-culture model MDA-MB231 and MCF-7 breast cancer spheroids were placed on immortalised lymphendothelial cell (LEC) monolayers...
April 7, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28393242/overexpression-of-srcin1-contributes-to-the-growth-and-metastasis-of-colorectal-cancer
#4
Mengnan Zhang, Feng Ma, Ruyi Xie, Yao Wu, Meiyan Wu, Pei Zhang, Ying Peng, Jinjun Zhao, Jing Xiong, Aimin Li, Cheng Kequan, Yali Zhang, Side Liu, Jide Wang, Xueqing Chen
The adaptor protein Srcin1 is a novel Src-binding protein that regulates Src activation through C-terminal Src kinase (Csk). Srcin1 behaves as a tumour suppressor in breast cancer, but the role of Srcin1 in the development of colorectal cancer (CRC) remains unknown. In the present study, Srcin1 expression in normal tissue was examined by tissue microarray and assessed by immunohistochemistry in 10 patients. In addition, the biological impact of Srcin1 knockdown on CRC cells was investigated in vitro and in vivo...
April 5, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28393230/the-mechanism-of-epithelial-mesenchymal-transition-induced-by-tgf-%C3%AE-1-in-neuroblastoma-cells
#5
Jing-Bo Shao, Zhi-Mei Gao, Wen-Yan Huang, Zhi-Bao Lu
Neuroblastoma is the second most common extracranial malignant solid tumor that occurs in childhood, and metastasis is one of the major causes of death in neuroblastoma patients. The epithelial-mesenchymal transition (EMT) is an important mechanism for both the initiation of tumor invasion and subsequent metastasis. Therefore, this study investigated the mechanism by which transforming growth factor (TGF)-β1 induces EMT in human neuroblastoma cells. Using quantitative RT-qPCR and western blot analyses, we found that the mRNA and protein expression levels of E-cadherin were significantly decreased, whereas that of α-SMA was significantly increased after neuroblastoma cells were treated with different concentrations of TGF-β1...
April 5, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28393212/sirt6-is-upregulated-and-associated-with-cancer-aggressiveness-in-papillary-thyroid-cancer-via-braf-erk-mcl%C3%A2-1-pathway
#6
Ning Qu, Jia-Qian Hu, Liang Liu, Ting-Ting Zhang, Guo-Hua Sun, Rong-Liang Shi, Qing-Hai Ji
Sirtuin 6 (SIRT6) is a member of the SIRT family NAD+‑dependent deacetylases reported to function in controlling organism homeostasis, lifespan, and diseases. This study investigated the role of SIRT6 in papillary thyroid cancer (PTC). Data of 391 PTC patients was extracted from The Cancer Genome Atlas database to investigate the expression of SIRTs (SIRT1‑7) and their relationship with clinicopathological parameters. Additional 45 pairs of PTC tumor tissues and corresponding non‑tumor tissues were studied using microarray analysis for SIRT6 expression...
April 5, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28393254/antitumor-effects-of-a-dual-specific-lentiviral-vector-carrying-the-escherichia-coli-purine-nucleoside-phosphorylase-gene
#7
Xiaolong Wang, Lei Sun, Xuejun Sun, Junhui Yu, Kai Wang, Yunhua Wu, Qi Gao, Jianbao Zheng
The Escherichia coli purine nucleoside phosphorylase/Fludarabine phosphate (ePNP/Fludara) suicide system has several drawbacks, such as side-effects and the low efficiency of ePNP expression. In this study, we evaluated the antitumor effects of the dual-specific 8HSEs-hTERTp-ePNP/Fludara suicide system under hyperthermia in vitro and in vivo. Luciferase activities from the 8HSEs‑hTERT and CMV promoters were compared using the dual luciferase assay in SW480 (high hTERT expression) and MKN74 cells (hTERT-negative) in the presence and absence of hyperthermia...
April 4, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28393237/microrna-10b-mediates-tgf-%C3%AE-1-regulated-glioblastoma-proliferation-migration-and-epithelial-mesenchymal-transition
#8
Chengyuan Ma, Feng Wei, Huan Xia, Haiyu Liu, Xuechao Dong, Yandong Zhang, Qinghua Luo, Yan Liu, Yang Li
Although it is well known that exaggerated proliferation, metastasis and the mesenchymal subtype is related with worst prognoses in glioblastoma (GBM) and that transforming growth factor-β1 (TGF-β1) is a potent factor in regulating the proliferation, migration and epithelial-mesenchymal transition (EMT) phenotype of GBM, the detailed mechanisms are still far from elucidated. MicroRNAs (miRNAs) are small non-coding RNAs which play critical roles in various diseases by regulating target gene expression. We report that miR-10b, a molecule downstream of TGF-β1, is involved in TGF-β1-regulated GBM cell proliferation, migration and EMT...
April 4, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28393219/inhibition-of-the-hedgehog-signaling-pathway-suppresses-cell-proliferation-by-regulating-the-gli2-mir-124-aurka-axis-in-human-glioma-cells
#9
Liyao Xu, Hua Liu, Zhangming Yan, Zhirong Sun, Shiwen Luo, Quqin Lu
Multiple lines of evidence indicate that aberrant activation of Hedgehog (Hh) signaling plays an important role in tumorigenesis in human glioma. However, the underlying molecular mechanism and crucial downstream targets of glioma-associated oncogene (Gli), a primary transcriptional regulator of Hh signaling, are not fully understood. Here, we report the identification of miR-124 as a novel downstream target of the transcriptional factor Gli2, which is important for proliferation and tumor growth in human glioma cells...
April 4, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28393176/mir-145-inhibits-proliferation-and-migration-of-breast-cancer-cells-by-directly-or-indirectly-regulating-tgf-%C3%AE-1-expression
#10
Yanling Ding, Chunfu Zhang, Jiahui Zhang, Nannan Zhang, Tao Li, Jie Fang, Yi Zhang, Feiyang Zuo, Zehua Tao, Shengnan Tang, Wei Zhu, Huabiao Chen, Xiaochun Sun
Studies have demonstrated low expression of miR-145 associated with cell proliferation and migration in a wide variety of tumors. Here, we studied the expression of miR-145 in relation to the occurrence and development of breast cancer. Total RNA from breast cancer tissue and corresponding adjacent normal tissue was extracted and used to detect miR-145 expression by quantitative real-time polymerase chain reaction (qRT-PCR). We also transfected breast cancer cells with hsa-miR-145 mimics, hsa-miR-145 inhibitor, mimics negative control (mimics NC) or inhibitor negative control (inhibitor NC)...
April 4, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28393205/high-annexin-a5-expression-promotes-tumor-progression-and-poor-prognosis-in-renal-cell-carcinoma
#11
Jingyuan Tang, Zhiqiang Qin, Peng Han, Wei Wang, Chengdi Yang, Zhen Xu, Ran Li, Bianjiang Liu, Chao Qin, Zengjun Wang, Min Tang, Wei Zhang
Annexin A5 has been found to act as an oncogenic protein in a variety of cancers. However, its specific biological role and mechanism in renal cell cancer (RCC) remains unknown. Quantitative Real-time PCR and western blotting were used to evaluate the mRNA and protein expression level of Annexin A5 in human RCC cell lines and tissues. Immunohistochemistry was adopted to measure the Annexin A5 expression in 123 cases of RCC tissues. Survival analysis was performed to explore the association between Annexin A5 expression and the prognosis of RCC...
April 3, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28358429/heat-shock-exerts-anticancer-effects-on-liver-cancer-via-autophagic-degradation-of-aquaporin-5
#12
Michihiro Kudou, Atsushi Shiozaki, Toshiyuki Kosuga, Hiroki Shimizu, Daisuke Ichikawa, Hirotaka Konishi, Ryo Morimura, Shuhei Komatsu, Hisashi Ikoma, Hitoshi Fujiwara, Kazuma Okamoto, Yoshinori Marunaka, Eigo Otsuji
Previous studies described that the expression of aquaporin 5 (AQP5) was altered in tumors of various organs. AQP5 is attracting attention as a new cancer therapeutic target. In the present study, heat shock-induced changes in AQP5 expression were evaluated by immunofluorescent staining (IF) and western blotting (WB) of liver cancer cells. AQP5 knockdown experiments or a heat shock treatment were conducted, and their effects on cell volume, proliferation, cell cycle, the activity of apoptosis and migration/invasion were compared...
March 29, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28358427/h19-promotes-the-migration-and-invasion-of-colon-cancer-by-sponging-mir-138-to-upregulate-the-expression-of-hmga1
#13
Qingqiang Yang, Xin Wang, Chunyan Tang, Xuan Chen, Jianjun He
Colon cancer is the most common digestive system malignancy, along with high mortality rate, familial transmissibility and hepatic metastasis. Our study investigated the role of long non-coding RNA H19 in colon cancer. We found that H19 was overexpressed in colon cancer tissues and cell lines, the interference of H19 by short hairpin RNA (shRNA) effectively decreased the migration and invasion of colon cancer cells (HT-29 and RKO). Besides, miR-138 was predicted a target of H19, and low expression of miR-138 was found in colon cancer tissues and cells...
March 29, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28358412/anticarcinogenic-effects-of-water-extract-of-sporoderm-broken-spores-of-ganoderma-lucidum-on-colorectal-cancer-in-vitro-and-in-vivo
#14
Kun Na, Kang Li, Tingting Sang, Kaikai Wu, Ying Wang, Xingya Wang
Ganoderma lucidum (G. lucidum) polysaccharides (GLPs) have been used as traditional Chinese medicine for cancer prevention for many years. However, the mechanism by which GLP exerts its chemopreventive activities remains elusive. In addition, it is unclear whether sporoderm-broken spores of G. lucidum water extract (BSGLWE), which contains mainly GLPs, has anticancer effects on colorectal cancer. The present study investigated the anticancer effects and potential mechanisms of BSGLWE on colorectal cancer in vivo and in vitro...
March 29, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28350132/a-new-facet-of-ndrg1-in-pancreatic-ductal-adenocarcinoma-suppression-of-glycolytic-metabolism
#15
Wensheng Liu, Bo Zhang, Qiangsheng Hu, Yi Qin, Wenyan Xu, Si Shi, Chen Liang, Qingcai Meng, Jinfeng Xiang, Dingkong Liang, Shunrong Ji, Jiang Liu, Pengfei Hu, Liang Liu, Chen Liu, Jiang Long, Quanxing Ni, Xianjun Yu, Jin Xu
N-myc downstream-regulated gene 1 (NDRG1) is known as tumor/metastasis suppressor in a variety of cancers including pancreas, being involved in angiogenesis, cancer growth and metastasis. However, the precise molecular mechanism how NDRG1 exerts its inhibitory function in pancreatic cancer remains unclear. In this investigation, we demonstrated that K-Ras plays a vital role in modulating NDRG1 protein level in PDAC cancer cells in vitro, which is mediated through ERK signaling. Noteworthy, K-Ras downstream Akt/mTOR signaling is inhibited upon NDRG1 overexpression, resulting in decease of HIF1α level...
March 28, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28350105/inflammatory-role-of-high-salt-level-in-tumor-microenvironment-review
#16
Suneetha Amara, Venkataswarup Tiriveedhi
Chronic inflammation is known to play a critical role in cancer development and progression. High salt is known to mediate several chronic inflammatory diseases including hypertension, myocardial infarction, neurological ischemic attack, autoimmune diseases and cancers. High salt level is shown to induce angiogenesis and immune-dysfunction, both of which play a direct role in cancer proliferation. Furthermore, salt has been suggested to enhance Warburg-like metabolic phenotype in cancer cells and at the same time also induce pro-tumor MΦ2-macrophage phenotype...
March 27, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28350094/routine-genetic-testing-of-lung-cancer-specimens-derived-from-surgery-bronchoscopy-and-fluid-aspiration-by-next-generation-sequencing
#17
Gou Yamamoto, Mari Kikuchi, Shiho Kobayashi, Yoshiko Arai, Kenji Fujiyoshi, Tomokazu Wakatsuki, Miho Kakuta, Yuki Yamane, Yoshihito Iijima, Hideaki Mizutani, Yuki Nakajima, Junko Sudo, Hiroyasu Kinoshita, Futoshi Kurimoto, Hirohiko Akiyama, Hidetaka Uramoto, Hiroshi Sakai, Yoshito Akagi, Kiwamu Akagi
After the development of EGFR tyrosine kinase inhibitors (TKIs), genetic testing of EGFR became required for effective treatment of lung cancer. Initially, the testing was conducted separately for each mutated region. However, many EGFR mutations have since been identified that determine the efficacy of EGFR-TKIs. Therefore, genetic testing of EGFR by next generation sequencing (NGS) may be a suitable strategy for lung cancer. Here we examined the applicability of the NGS method in regard to sensitivity, time and cost...
March 27, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28350091/clinical-implication-of-frizzled-2-expression-and-its-association-with-epithelial-to-mesenchymal-transition-in-hepatocellular-carcinoma
#18
Tomonari Asano, Suguru Yamada, Bryan C Fuchs, Hideki Takami, Masamichi Hayashi, Hiroyuki Sugimoto, Tsutomu Fujii, Kenneth K Tanabe, Yasuhiro Kodera
The epithelial-to-mesenchymal transition (EMT) is an initial, critical step in hepatocellular carcinoma (HCC) tumor invasion and metastasis. Frizzled 2 (Fzd2) expression might drive EMT through the non-canonical Wnt pathway, one of the various EMT signaling pathways. The expression of epithelial (E-cadherin) and mesenchymal (vimentin) markers, as well as that of Wnt5b, Stat3, IL-6, Jak2 and Fzd2, were measured in 15 HCC cell lines. The EMT status (vimentin to E-cadherin mRNA expression ratio), Fzd2 mRNA expression, and pSTAT3 protein expression were assessed by immunostaining in 100 HCC patients, and correlations of their expression with clinicopathological factors and prognosis were analyzed...
March 27, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28339037/the-long-non-coding-rna-lncfoxo1-suppresses-growth-of-human-breast-cancer-cells-through-association-with-bap1
#19
Jie Xi, Jing Feng, Qian Li, Xia Li, Saitian Zeng
Breast cancer, one of the common cancers of women, is the leading cause of death among women below the age of 50 years in western countries. Long non-coding RNAs (lncRNAs) have been shown to be involved in diverse biological processes, both physical and pathological. However, to date, only a few lncRNAs have been functionally identified in breast cancer, and the overall pathophysiological contributions of lncRNAs to breast cancer remain largely unknown. In the present study, we identified a novel lncRNA termed lncFOXO1 through microarray screening...
March 24, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28339029/hydroxychloroquine-sensitizes-chronic-myeloid-leukemia-cells-to-v%C3%AE-9v%C3%AE-2-t-cell-mediated-lysis-independent-of-autophagy
#20
Biqing Han, Yanmin Zhao, Yu Lin, Shan Fu, Limengmeng Wang, Mingming Zhang, Ruxiu Tie, Binsheng Wang, Yi Luo, Lizhen Liu, Jian Yu, He Huang
Hydroxychloroquine (HCQ) is the only autophagy inhibitor in clinical use and it has shown great potential in treating chronic myeloid leukemia (CML). By inhibiting autophagy, HCQ enhances the anti-CML efficiency of chemotherapy. In the present study, we demonstrated that HCQ sensitized CML cells to Vγ9Vδ2 T cell-mediated lysis. HCQ inhibited autophagy in CML cells, but the sensitizing effects of HCQ were autophagy-independent. Since the sensitization was not mimicked by ATG7 knockdown and even occurred in the absence of ATG7...
March 24, 2017: International Journal of Oncology
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