journal
MENU ▼
Read by QxMD icon Read
search

International Journal of Oncology

journal
https://www.readbyqxmd.com/read/28260095/inhibin-%C3%AE-gene-mutations-and-mrna-levels-in-human-lymphoid-and-myeloid-leukemia-cells
#1
Young Il Kim, Seung-Won Park, Hye Shin Kwon, Hyung-Seok Yang, Sun Young Cho, Young Jin Kim, Hee Joo Lee
The inhibin-α gene was identified as a tumor suppressor gene in the gonads and adrenal glands by functional studies using knockout mice. Methylation of CpG sites within the regulatory regions of tumor suppressor gene is frequently associated with their transcriptional silencing. We investigated epigenetic modifications, changes in loss of heterozygosity (LOH), and mutation of the inhibin-α gene, and regulation of transcriptional expression in response to inhibitors of DNA methylation (5-aza-2'-deoxycytidine, 5-AzaC) in human lymphoid (Jurkat, Molt-4, Raji, and IM-9) and myeloid (HL-60, Kasumi-1, and K562) leukemia cells...
March 2, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28259975/gene-expression-profiling-in-bladder-cancer-identifies-potential-therapeutic-targets
#2
Syed A Hussain, Daniel H Palmer, Wing-Kin Syn, Joseph J Sacco, Richard M D Greensmith, Taha Elmetwali, Vijay Aachi, Bryony H Lloyd, Puthen V Jithesh, John Arrand, Darren Barton, Jawaher Ansari, D Ross Sibson, Nicholas D James
Despite advances in management, bladder cancer remains a major cause of cancer related complications. Characterisation of gene expression patterns in bladder cancer allows the identification of pathways involved in its pathogenesis, and may stimulate the development of novel therapies targeting these pathways. Between 2004 and 2005, cystoscopic bladder biopsies were obtained from 19 patients and 11 controls. These were subjected to whole transcript-based microarray analysis. Unsupervised hierarchical clustering was used to identify samples with similar expression profiles...
March 2, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28259974/3-hydroxyterphenyllin-a-natural-fungal-metabolite-induces-apoptosis-and-s-phase-arrest-in-human-ovarian-carcinoma-cells
#3
Yaomin Wang, Casey Compton, Gary O Rankin, Stephen J Cutler, Yon Rojanasakul, Youying Tu, Yi Charlie Chen
In the present study, we evaluated 3-Hydroxyter-phenyllin (3-HT) as a potential anticancer agent using the human ovarian cancer cells A2780/CP70 and OVCAR-3, and normal human epithelial ovarian cells IOSE-364 as an in vitro model. 3-HT suppressed proliferation and caused cytotoxicity against A2780/CP70 and OVCAR-3 cells, while it exhibited lower cytotoxicity in IOSE-364 cells. Subsequently, we found that 3-HT induced S phase arrest and apoptosis in a dose-independent manner. Further investigation revealed that S phase arrest was related with DNA damage which mediated the ATM/p53/Chk2 pathway...
March 2, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28259973/furin-promotes-epithelial-mesenchymal-transition-in-pancreatic-cancer-cells-via-hippo-yap-pathway
#4
Youli Zhang, Meng Zhou, Hong Wei, Hailang Zhou, Junbo He, Ying Lu, Dawei Wang, Baoding Chen, Jian Zeng, Wanxin Peng, Fengyi Du, Aihua Gong, Min Xu
Furin, a well-characterized proprotein convertase, plays an important role in many diseases and links to tumor metastasis. However, the role of furin in pancreatic cancer progression remains to be elucidated. In the present study, we found that furin promotes the growth and the epithelial-mesenchymal transition (EMT) of pancreatic cancer cells. First, we found that furin knockdown significantly inhibited proliferation, invasion and migration in BxPC3 and SW1990 cells, while furin overexpression promoted the above behavior in PANC1 and PaTu8988 cells...
March 2, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28260038/the-nerve-growth-factor-alters-calreticulin-translocation-from-the-endoplasmic-reticulum-to-the-cell-surface-and-its-signaling-pathway-in-epithelial-ovarian-cancer-cells
#5
Carolina Andrea Vera, Lorena Oróstica, Fernando Gabler, Arturo Ferreira, Alberto Selman, Margarita Vega, Carmen Aurora Romero
Ovarian cancer is the seventh most common cancer among women worldwide, causing approximately 120,000 deaths every year. Immunotherapy, designed to boost the body's natural defenses against cancer, appears to be a promising option against ovarian cancer. Calreticulin (CRT) is an endoplasmic reticulum (ER) resident chaperone that, translocated to the cell membrane after ER stress, allows cancer cells to be recognized by the immune system. The nerve growth factor (NGF) is a pro-angiogenic molecule overexpressed in this cancer...
February 28, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28259988/targeting-glutamine-metabolism-and-the-focal-adhesion-kinase-additively-inhibits-the-mammalian-target-of-the-rapamycin-pathway-in-spheroid-cancer-stem-like-properties-of-ovarian-clear-cell-carcinoma-in%C3%A2-vitro
#6
Masakazu Sato, Kei Kawana, Katsuyuki Adachi, Asaha Fujimoto, Mitsuyo Yoshida, Hiroe Nakamura, Haruka Nishida, Tomoko Inoue, Ayumi Taguchi, Juri Ogishima, Satoko Eguchi, Aki Yamashita, Kensuke Tomio, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fujii
Ovarian cancer is one of the leading causes of death in the world, which is linked to its resistance to chemotherapy. Strategies to overcome chemoresistance have been keenly investigated. Culturing cancer cells in suspension, which results in formation of spheroids, is a more accurate reflection of clinical cancer behavior in vitro than conventional adherent cultures. By performing RNA-seq analysis, we found that the focal adhesion pathway was essential in spheroids. The phosphorylation of focal adhesion kinase (FAK) was increased in spheroids compared to adherent cells, and inhibition of FAK in spheroids resulted in inhibition of the downstream mammalian target of the rapamycin (mTOR) pathway in ovarian clear cell carcinomas...
February 23, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28259945/rb-deficiency-accelerates-progression-of-carcinoma-of-the-urinary-bladder-in-vivo-and-in-vitro-through-inhibiting-autophagy-and-apoptosis
#7
Cheng-Yuan Wang, Zhi-Bin Xu, Jiang-Ping Wang, Yong Jiao, Bo Zhang
Urinary bladder cancer is known as a common cancer diagnosed across the world and results in significant mortality and morbidity rates among patients. The retinoblastoma (Rb) protein, as a main tumor suppressor, controls cellular responses to potentially oncogenic stimulation. Rb phosphorylation could disrupt E2F complex formation, resulting in diverse transcription factor dysfunction. In our study, we investigated how Rb is involved in controlling urinary bladder cancer progression. The results indicate that Rb expression is reduced in mice with urinary bladder tumor, and its suppression leads to urinary bladder cancer progression in vivo and in vitro...
February 22, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28259944/ursolic-acid-nanoparticles-inhibit-cervical-cancer-growth-in-vitro-and-in-vivo-via-apoptosis-induction
#8
Shaoguang Wang, Xiaomei Meng, Yaozhong Dong
Cervical cancer is a cause of cancer death, making it one of the most common causes of death among women globally. Previously, a variety of studies have revealed the molecular mechanisms by which cervical cancer develops. However, there are still limitations in treatment for cervical cancer. Ursolic acid is a naturally derived pentacyclic triterpene acid, exhibiting broad anticancer effects. Nanoparticulate drug delivery systems have been known to better the bioavailability of drugs on intranasal administration compared with only drug solutions...
February 22, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28259934/curcumin-reverses-benzidine-induced-epithelial-mesenchymal-transition-via-suppression-of-erk5-ap-1-in-sv-40-immortalized-human-urothelial-cells
#9
Zhiqi Liu, Jie Liu, Li Zhao, Hao Geng, Jiaxing Ma, Zhiqiang Zhang, Dexin Yu, Caiyun Zhong
Overexposure to benzidine has been manifested as an important cause of bladder cancer. However, the molecular mechanism of benzidine-induced malignancy is still insufficiently interpreted. Epithelial-mesenchymal transition (EMT) is a crucial pathophysiological process in embryonic development as well as initiation and development of epithelium-originated malignant tumors. The role of extracellular regulated protein kinase 5 (ERK5) in benzidine-meditated bladder cancer development has not been explored. In the present study, we explored the role of ERK5/AP-1 pathway in benzidine-induced EMT in human normal urothelial cells and the intervention effect of curcumin on bezidine-induced EMT...
February 21, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28259904/silencing-snail-suppresses-tumor-cell-proliferation-and-invasion-by-reversing-epithelial-to-mesenchymal-transition-and-arresting-g2-m-phase-in-non-small-cell-lung-cancer
#10
Xueying Yang, Mengmeng Han, Haibo Han, Bingjing Wang, Sheng Li, Zhiqian Zhang, Wei Zhao
Epithelial-to-mesenchymal transition (EMT) is essential for tumor invasion and metastasis. Snail has been proven to be a key regulator of EMT. Several studies have shown compelling evidence that Snail is also an important regulator of tumor growth and aggression; however, the role of Snail in the cell cycle has not been clarified. We decreased Snail expression by siRNA transfection and lentiviral‑mediated RNAi, to explore the effect of silencing Snail on the tumorigenicity and migration of lung carcinoma (lung cancer) cells...
February 21, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28260049/inflammatory-peroxidases-promote-breast-cancer-progression-in-mice-via-regulation-of-the-tumour-microenvironment
#11
Vasilios Panagopoulos, Damien A Leach, Irene Zinonos, Vladimir Ponomarev, Giovanni Licari, Vasilios Liapis, Wendy V Ingman, Peter Anderson, Mark O DeNichilo, Andreas Evdokiou
Myeloperoxidase (MPO) and eosinophil peroxidase (EPO) are heme-containing enzymes, well known for their antimicrobial activity, are released in high quantities by infiltrating immune cells in breast cancer. However, the functional importance of their presence within the tumour microenvironment is unclear. We have recently described a new role for peroxidases as key regulators of fibroblast and endothelial cell functionality. In the present study, we investigate for the first time, the ability of peroxidases to promote breast cancer development and progression...
February 20, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28259967/enhanced-expression-of-%C3%AE-2-3-linked-sialic-acids-promotes-gastric-cancer-cell-metastasis-and-correlates-with-poor-prognosis
#12
Li Shen, Zhiguo Luo, Junbo Wu, Li Qiu, Ming Luo, Qing Ke, Xiaoxia Dong
Gastric cancer (GC) is a highly metastatic disease and one of the leading causes of cancer death in the world. Aberrant glycosylation is one of many molecular changes that accompany malignant transformation. This study was aimed at identification of glycan profiling changes in GC progression and its potential mechanisms. We employed a microarray with 91 lectins to compare the differential glycans in the three human GC cell lines, SGC-7901, BGC-823 and MGC-803. According to glycan-binding specificities of lectins, all GC cell lines expressed common sugar structures, such as mannose, galactose and fucose...
February 20, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28259897/dual-roles-of-protein-tyrosine-phosphatase-kappa-in-coordinating-angiogenesis-induced-by-pro-angiogenic-factors
#13
Ping-Hui Sun, Gang Chen, Malcolm Mason, Wen G Jiang, Lin Ye
A potential role may be played by receptor-type protein tyrosine phosphatase kappa (PTPRK) in angiogenesis due to its critical function in coordinating intracellular signal transduction from various receptors reliant on tyrosine phosphorylation. In the present study, we investigated the involvement of PTPRK in the cellular functions of vascular endothelial cells (HECV) and its role in angiogenesis using in vitro assays and a PTPRK knockdown vascular endothelial cell model. PTPRK knockdown in HECV cells (HECVPTPRKkd) resulted in a decrease of cell proliferation and cell-matrix adhesion; however, increased cell spreading and motility were seen...
February 20, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28259896/the-one-carbon-metabolism-pathway-highlights-therapeutic-targets-for-gastrointestinal-cancer-review
#14
Masamitsu Konno, Ayumu Asai, Koichi Kawamoto, Naohiro Nishida, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii
After the initial use of anti-folates for treatment of malignancies, folate metabolism has emerged as a rational diagnostic and therapeutic target in gastrointestinal cancer. The one-carbon metabolic pathway, which comprises three critical reactions (i.e., folate and methionine cycles), underlies this effect in conjunction with the trans-sulfuration pathway. Understanding of the one-carbon metabolism pathway has served to unravel the link between the causes and effects of cancer phenotypes leading to several seminal discoveries such as that of diadenosine tri-phosphate hydrolase, microRNAs, 5-FU and, more recently, trifluridine...
February 20, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28259895/quercetin-nanoparticles-display-antitumor-activity-via-proliferation-inhibition-and-apoptosis-induction-in-liver-cancer-cells
#15
Ke-Wei Ren, Ya-Hua Li, Gang Wu, Jian-Zhuang Ren, Hui-Bin Lu, Zong-Ming Li, Xin-Wei Han
Quercetin is a potent cancer therapeutic agent and dietary antioxidant present in fruit and vegetables. Quercetin prevents tumor proliferation by inducing cell cycle arrest and is a well known cancer therapeutic agent and autophagy mediator. Recent studies showed that drug delivery by nanoparticles have enhanced efficacy with reduced side effects. In this regard, gold-quercetin into poly(DL-lactide-co-glycolide) nanoparticles was examined. In this study, we explored the role and possible underlying mechanisms of quercetin nanoparticle in regulation of antitumor activity in liver cancer cells...
February 20, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28260026/ube2c-induces-emt-through-wnt-%C3%AE-%C3%A2-catenin-and-pi3k-akt-signaling-pathways-by-regulating-phosphorylation-levels-of-aurora-a
#16
Rui Wang, Yue Song, Xi Liu, Qixue Wang, Yunfei Wang, Liwei Li, Chunsheng Kang, Qingyu Zhang
The ubiquitin-conjugating enzyme 2C (UBE2C) is the key component in the ubiquitin proteasome system (UPS) by partnering with the anaphase‑promoting complex (APC/C). A high UBE2C protein expression level has been reported in various types of human tumors. However, little is known about the precise mechanism by which UBE2C expression is downregulated in gastric cancer. We found in MGC‑803 and SGC‑7901 gastric cancer cells UBE2C‑deficient G2/M phase arrest in the cell cycle and subsequently decreased gastric adenocarcinoma tumorigenesis...
February 17, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28259983/therapeutic-effects-of-schisandra-chinensis-on-the-hyperprolactinemia-in-rat
#17
So-Hye Hong, Mei Li, Eui-Bae Jeung, Geun-Shik Lee, Eui-Ju Hong, Young-Whan Choi, Beum-Soo An
Prolactin (PRL) is secreted from the pituitary gland in response to eating, mating, and ovulation. Increased serum concentration of PRL during pregnancy contributes to enlargement of the mammary glands of the breasts and prepares for production of milk. However, high PRL levels derived from prolactinoma and hyperprolactinemia induce physiological disorders such as infertility and early menopause. Natural compounds isolated from S. chinensis have been known to possess anti-oxidative, anti-inflammatory and anti-diabetic effects...
February 17, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28259926/suppression-of-cancer-stem-like-phenotypes-in-nci-h460-lung-cancer-cells-by-vanillin-through-an-akt-dependent-pathway
#18
Songpol Srinual, Pithi Chanvorachote, Varisa Pongrakhananon
Cancer stem cells (CSCs) have been reported as a major cause of cancer metastasis and the failure of cancer treatment. Cumulative studies have indicated that protein kinase B (Akt) and its downstream signaling pathway, including CSC markers, play a critical role in the aggressive behavior of this cancer. In this study, we investigated whether vanillin, a major component in Vanilla planifolia seed, could suppress cancer stemness phenotypes and related proteins in the human non-small cell lung cancer NCI‑H460 cell line...
February 17, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28259978/ectopic-expression-of-the-atp-synthase-%C3%AE-subunit-on-the-membrane-of-pc-3m-cells-supports-its-potential-role-in-prostate-cancer-metastasis
#19
Wei Li, Yulin Li, Gaiyun Li, Zilong Zhou, Xiaona Chang, Yang Xia, Xinjie Dong, Zhijing Liu, Bo Ren, Wei Liu, Yilei Li
Metastatic prostate cancer is associated with high mortality rates. Identification of metastasis-related proteins may facilitate the development of novel therapies for the treatment of metastatic disease. In the present study, we aimed to identify prostate cancer metastasis-associated membrane proteins. We developed a phage-displayed 7-mer peptide library to screen the target peptides that were specifically bound to PC-3M cells with subtractive panning from normal prostate cells and PC-3 prostate cancer cells...
February 16, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28259905/matrix-stiffness-regulates-the-proliferation-stemness-and-chemoresistance-of-laryngeal-squamous-cancer-cells
#20
Lian Hui, Jingru Zhang, Xiaoxu Ding, Xing Guo, Xuejun Jiang
Increasing evidence shows that matrix stiffness plays a critical role in affecting the phenotype and behavior of tumor cells. We report that matrix stiffness significantly regulated the proliferation and chemotherapeutic response of Hep-2 cells. Increasing substrate stiffness promotes the proliferation of Hep-2 cells. When cultured on soft gels, Hep-2 cells expressed higher level of stem cell markers. Following treatment with cisplatin or 5-FU, we observed reduced apoptosis in Hep-2 cells cultured on soft supports...
February 15, 2017: International Journal of Oncology
journal
journal
31308
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"