journal
MENU ▼
Read by QxMD icon Read
search

Clinical and Experimental Hypertension: CHE

journal
https://www.readbyqxmd.com/read/28287891/associations-of-resting-heart-rate-with-endothelium-dependent-vasodilation-and-shear-rate
#1
Jitanan Laosiripisan, Kristin L Parkhurst, Hirofumi Tanaka
Heart rate is an independent risk factor for cardiovascular disease and a hemodynamic factor that can modulate blood flow as it affects the frequency of shear stimuli acting on the arterial wall. However, the association between heart rate and endothelium-dependent vasodilation remains highly controversial. We determined the association between heart rate at rest and endothelium-dependent vasodilation in 98 apparently healthy adults (18-63 years). The mild and positive association between heart rate and flow-mediated dilation (FMD) was no longer significant when age and sex or baseline diameter were controlled for...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28287890/adrb2-polymorphisms-and-dyslipidemia-risk-in-chinese-hypertensive-patients
#2
Wei Gu, Jilin Liu, Zuoguang Wang, Ya Liu, Shaojun Wen
Single nucleotide polymorphisms (SNPs) within a β-adrenergic receptor (ADRB2) were shown to be related to lipid traits or hyperlipidemia in different ethnicities, but not in a Chinese population. We performed the present study to investigate the possible relationship between them in a Chinese hypertensive population. Seven hundred and eighty-three hypertensive subjects were enrolled in the hospital-based retrospective research. Using the TaqMan PCR method, three polymorphisms (C-47T, A46G, and C79G) of ADRB2 were detected...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28287889/impact-of-high-fat-high-salt-diet-on-myocardial-oxidative-stress
#3
Fadia Mayyas, Karem H Alzoubi, Zahraa Al-Taleb
BACKGROUND: High fat high salt diet contributes to oxidative stress and cardiac diseases. AIMS: To determine the impact of moderately high fat diet (HFD), high salt (HS) or their combination on blood pressure (Bp) and myocardial oxidants/antioxidants. METHODS: Sprague Dawley rats were assigned into four groups; conventional diet (control, 5% fat, 0.5% NaCl), HFD (25% fat, 0.5% NaCl), HS (5% fat, 8% NaCl), or combined diet (HFD+HS) for 10 weeks...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28287888/mir-942-decreased-before-20-weeks-gestation-in-women-with-preeclampsia-and-was-associated-with-the-pathophysiology-of-preeclampsia-in-vitro
#4
Yonggang Zhang, Guoqing Huang, Yipeng Zhang, Hongling Yang, Yan Long, Qihua Liang, Zaoxiong Zheng
OBJECTIVE: To investigate the possible relationship between miR-942 levels and the pathogenesis of preeclampsia using in vitro assays and to investigate circulating miR-942 levels in the early phase of mid-of pregnancy in women who later developed preeclampsia and in women with uncomplicated pregnancies. METHODS: Plasma samples were collected from pregnant women between 12 and 20 weeks of gestation. MiR-942 levels were determined by stem-loop real-time PCR for 26 cases who subsequently developed preeclampsia as well as for 52 controls...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28287887/a-comprehensive-review-of-an-unmet-public-health-issue-resistant-hypertension
#5
Anping Cai, Yingqing Feng, Yingling Zhou
Resistant hypertension is an intractable problem to patients and physicians. In recent decades, a substantial amount of basic and epidemiological studies provide us a vast number of valuable evidence and information about this once elusive disease. Better understanding about this entity could help physicians improve diagnostic and therapeutic accuracy. In present review, therefore, we first will detail the definition and diagnosis of resistant hypertension between cardiology societies, and followed by the information of prevalence of resistant hypertension around the world, and then briefly discuss currently used different nomenclature of resistant hypertension, and finally present diagnostic and therapeutic strategies of resistant hypertension...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28287886/overexpressed-connective-tissue-growth-factor-in-cardiomyocytes-attenuates-left-ventricular-remodeling-induced-by-angiotensin-ii-perfusion
#6
Ying Zhang, Hua Yan, Gong-Chang Guang, Zheng-Rong Deng
To evaluate the improving effects of specifically overexpressed connective tissue growth factor (CTGF) in cardiomyocytes on mice with hypertension induced by angiotensin II (AngII) perfusion, 24 transgenic mice with cardiac-restricted overexpression of CTGF (Tg-CTGF) were divided into two equal groups that were perfused with acetic acid and AngII, respectively, for 7 days. Another 24 cage-control wild-type C57BL/6 mice (NLC) were divided and treated identically. Blood pressure was detected by caudal artery cannulation...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28287885/homocysteine-levels-and-risk-of-essential-hypertension-a-meta-analysis-of-published-epidemiological-studies
#7
Fade Zhong, Li Zhuang, Ying Wang, Youli Ma
BACKGROUND: Plasma homocysteine (Hcy) levels may be associated with essential hypertension (EH). However, the results of previous studies on this association are inconsistent. METHODS: In this meta-analysis, we performed a systematic literature search of the Embase, PubMed, Cochrane Library, and Web of Science for the relevant articles dated up to March 2016. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to evaluate the estimates...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28287884/circulating-mirna29-family-expression-levels-in-patients-with-essential-hypertension-as-potential-markers-for-left-ventricular-hypertrophy
#8
Yuqing Huang, Songtao Tang, Cheng Huang, Jiyan Chen, Jie Li, Anping Cai, Yingqing Feng
OBJECTIVES: The role of microRNAs (miRs,miRNAs) in the pathogenesis of cardiovascular diseases such as hypertension, as well as their diagnostic potential, has recently attracted much attention. However, target-organ damage (TOD) of hypertension remains a substantial challenge due to the lack of specific biomarkers. The present study was undertaken to identify and validate the potential of circulating miRs as novel biomarkers for TOD. METHODS: We assessed the expression levels of miR-29a, miR-29b, and miR-29c in 54 patients with untreated essential hypertension and 30 healthy individuals...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28287883/endothelial-nitric-oxide-synthase-gene-single-nucleotide-polymorphisms-and-the-risk-of-hypertension-a-meta-analysis-involving-63-258-subjects
#9
Xiaochuan Xie, Xiaohan Shi, Xiaoshuang Xun, Li Rao
The endothelial nitric oxide synthase (eNOS) gene plays an important role in regulating vascular tone and blood pressure. Recently, the eNOS G894T and T-786C single nucleotide polymorphisms (SNPs) were intensively studied with regard to their associations with hypertension. However, the results of these studies were inconsistent. Therefore, we conducted the so far largest meta-analysis to better assess the correlations between eNOS SNPs and hypertension. Eligible articles were searched in PubMed, Medline, Embase, Scopus, and CNKI up to April 2016...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28287882/endothelium-independent-vasorelaxant-activity-of-trachyspermum-ammi-essential-oil-on-rat-aorta
#10
G Sargazi Zadeh, N Panahi
Several pharmacological activities of the essential oil of Trachyspermum ammi seeds (TAEO) have been previously studied. These include antitussive, antihypertensive, and antispasmodic effects. However, its action on isolated aorta has not yet been studied. This study was aimed to investigate the vasorelaxant activity of TAEO and characterize its mechanism of action. Extraction of TAEO was performed using Clevenger-type apparatus with the final content of 4.5% (v/w). To evaluate some probable mechanisms of action of TAEO, the action isometric tension was then measured in the aortic rings from Wistar rats which were precontracted with phenylephrine (PHE) (1 µM) or KCl (60 mM)...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28287881/renin-angiotensin-system-blockade-alone-or-combined-with-eta-receptor-blockade-effects-on-the-course-of-chronic-kidney-disease-in-5-6-nephrectomized-ren-2-transgenic-hypertensive-rats
#11
Lenka Sedláková, Věra Čertíková Chábová, Šárka Doleželová, Petra Škaroupková, Libor Kopkan, Zuzana Husková, Lenka Červenková, Soňa Kikerlová, Ivana Vaněčková, Janusz Sadowski, Elzbieta Kompanowska-Jezierska, Petr Kujal, Herbert J Kramer, Luděk Červenka
BACKGROUND: Early addition of endothelin (ET) type A (ETA) receptor blockade to complex renin-angiotensin system (RAS) blockade has previously been shown to provide better renoprotection against progression of chronic kidney disease (CKD) in Ren-2 transgenic hypertensive rats (TGR) after 5/6 renal ablation (5/6 NX). In this study, we examined if additional protection is provided when ETA blockade is applied in rats with already developed CKD. METHODS: For complex RAS inhibition, an angiotensin-converting enzyme inhibitor along with angiotensin II type 1 receptor blocker was used...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28287880/does-the-serum-uric-acid-level-have-any-relation-to-arterial-stiffness-or-blood-pressure-in-adults-with-congenital-renal-agenesis-and-or-hypoplasia
#12
Raziye Yazici, İbrahim Guney, Lutfullah Altintepe, Mehmet Yazici
BACKGROUND: The relationship between serum uric acid and arterial stiffness or blood pressure is not clear. The serum uric acid level and its association with cardiovascular risk is not well known in patients with reduced renal mass. We aimed to investigate the relation between serum uric acid levels and arterial stiffness and also blood pressure in patients with congenital renal agenesis and/or hypoplasia. MATERIAL AND METHODS: In this single center, cross-sectional study, a total of 55 patients (39 (% 70...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28287879/circadian-blood-pressure-abnormalities-in-patients-with-primary-nephrotic-syndrome
#13
Kotaro Haruhara, Nobuo Tsuboi, Kentaro Koike, Go Kanzaki, Yusuke Okabayashi, Takaya Sasaki, Akira Fukui, Yoichi Miyazaki, Tetsuya Kawamura, Makoto Ogura, Takashi Yokoo
BACKGROUND: Only a few studies have evaluated the abnormalities of ambulatory blood pressure (ABP) in patients with nephrotic syndrome (NS). METHODS: The 24-h ABPs were measured in primary NS patients with acute onset of disease and analyzed in relation to the clinical variables. RESULTS: Our subjects comprised 21 patients: 17 with minimal change disease and 4 with focal segmental glomerulosclerosis. Of these patients, 8 (38%) had daytime hypertension, 13 (62%) had nighttime hypertension, and 13 (62%) were non-dippers (nighttime-to-daytime ratio of ABP: NDR > 0...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28287878/association-of-peroxisome-proliferator-activated-receptor-delta-and-additional-gene-smoking-interaction-on-cardiovascular-disease
#14
Wenqi Yang, Shudan Mao, Baoze Qu, Fengxiang Zhang, Zhaolong Xu
AIMS: To investigate the impact of peroxisome proliferator-activator receptor delta (PPARD) gene polymorphism and additional gene-smoking interaction on cardiovascular disease (CVD) risk based on this Chinese population. METHODS: A total of 1048 subjects (617 males, 431 females) with a mean age of 52.9 ± 14.1 years old were selected, including 520 CVD patients and 528 normal control subjects. The logistic regression model was used to examine the association between three SNPs and CVD risk, odds ratio (OR), and 95% confident interval (95%CI) were calculated...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28072557/expression-and-localization-of-the-at1-and-at2-angiotensin-ii-receptors-and-%C3%AE-1a-and-%C3%AE-1d-adrenergic-receptors-in-aorta-of-hypertensive-and-diabetic-rats
#15
Jessica Edith Rodríguez, Rodrigo Romero-Nava, Aldo Arturo Reséndiz-Albor, Erika Rosales-Cruz, Enrique Hong, Fengyang Huang, Santiago Villafaña
Hypertension and diabetes are multifactorial diseases that frequently coexist and exacerbate each another. During the development of diabetes, the impairment of noradrenergic and renin-angiotensin systems has been reported in the response mediated by α1-AR and AT1 receptors. Although their participation in the development of cardiovascular complications is still controversial, some studies have found increased or diminished response to the vasoconstrictive effect of noradrenaline or angiotensin II in a time-dependent manner of diabetes...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28072551/assessment-of-subclinical-left-ventricular-changes-in-essential-hypertensive-patients-with-hyperuricemia-a-three-dimensional-speckle-tracking-echocardiography-study
#16
Xiaoyan Fang, Cuizhen Pan, Yongle Chen, Minmin Sun, Zhuojun Zhang, Lindi Jiang, Xiaolin Wang, Xianhong Shu
OBJECTIVE: To evaluate the effect of hyperuricemia (HU) on subclinical changes of left ventricle (LV) function and structure in patients with hypertension (HT) using three-dimensional speckle-tracking echocardiography (3DSTE) and to explore the relationships between serum uric acid (SUA) levels and three-dimensional speckle tracking echocardiography (3DSTE) parameters in hypertensive and nonhypertensive patients with HU. METHODS: Four age- and sex-matched groups were studied: I: healthy controls, HT- HU- (n = 40); II: HT- HU+ (n = 40); III: HT+ HU- (n = 40); IV: HT+ HU+ (n = 44)...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28071980/metabolic-syndrome-hypertension-and-nervous-system-injury-epidemiological-correlates
#17
REVIEW
Giovanna Ricci, Isabel Pirillo, Daniele Tomassoni, Ascanio Sirignano, Iolanda Grappasonni
Metabolic syndrome (MetS) is a common and complex disorder combining hypertension, obesity, dyslipidemia, and insulin resistance. MetS represents a risk factor for changes in cognitive functions in older age, and several studies have suggested that MetS may be linked to dementia. This article reviews the main evidences about the relationship between MetS and neurodegenerative disease. Starting from an epidemiological point of view, the article analyzes medico-social aspects related to MetS, considering the reduction of work capacity and the condition of disability that it involves...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28067546/association-of-g-protein-beta3-subunit-gene-c825t-polymorphism-with-cardiac-and-cerebrovascular-events-in-chinese-hypertensive-patients
#18
Weiwei Zhu, Jing Li, Xipeng Sun, Qi Hua
Several recent studies showed that C825T polymorphism is related to cardiovascular diseases in normal population. However, studies on whether 825T allele influences the incidence of cardiovascular diseases in hypertensive patients are rare. In the current study, 729 patients (CC, n = 332; CT, n = 313; TT, n = 84) with essential hypertension were genotyped for C825T polymorphism of the GNB3 gene and followed 8 years for major adverse cardiovascular events (MACEs) which include stroke, the onset of coronary artery disease (CAD), and all-cause death...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28060542/puerarin-protects-against-endothelial-dysfunction-and-end-organ-damage-in-ang-ii-induced-hypertension
#19
Xiaojie Li, Yuhan Lin, Hongyu Zhou, Yao Li, Aimei Wang, Hongxin Wang, Ming-Sheng Zhou
Puerarin, a major isoflavonoid compound from Chinese herb Kudzu roots, has been widely used for the treatment of hypertensive and cardiovascular diseases in China. Here, we investigated puerarin's beneficial effects on the cardiovascular system in angiotensin (Ang) II-induced hypertensive rats. Sprague-Dawley rats were treated with Ang II for 5 days or with puerarin for 10 days followed by Ang II and puerarin for 5 days. Endothelium-dependent relaxation (EDR) to acetylcholine was determined using an organ chamber bath...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28060538/persistent-albuminuria-as-a-surrogate-marker-of-chronic-kidney-damage-among-newly-diagnosed-hypertensives-prevalence-and-risk-factors-in-an-urban-population-in-karachi-pakistan
#20
Muslima Ejaz, Ejaz Ahmed, Muhammed Mubarak, Juanita Hatcher, Tazeen Jaffar
BACKGROUND: Hypertension is a major public health problem worldwide and a key factor for chronic kidney disease (CKD). Detection and treatment of CKD is of paramount importance. Albuminuria is one of the earliest screening markers recommended in patients at increased risk for CKD. OBJECTIVE: We conducted this study to determine the prevalence of persistent albuminuria (PA) in newly diagnosed hypertensive subjects and to study its associated risk factors. METHODS: A total of 173 (72%) of 240 subjects among 1340 newly diagnosed hypertensive subjects from an ongoing community-based cohort study who had been screened once for the presence of albuminuria were retested for the presence of PA in this study...
2017: Clinical and Experimental Hypertension: CHE
journal
journal
31305
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"