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Clinical and Experimental Hypertension: CHE

Dalton de Lima-Junior, Breno Quintella Farah, Antonio Henrique Germano-Soares, Aluísio Andrade-Lima, Gustavo Oliveira Silva, Sergio Luiz Cahu Rodrigues, Raphael Ritti-Dias
BACKGROUND: Increased handgrip strength has been associated with lower cardiovascular and non-cardiovascular mortality in different populations. In patients with hypertension, arterial stiffness relates to cardiovascular mortality. However, whether muscle strength is associated with arterial stiffness in hypertensives is unknown. Thus, the objective of this study was to analyze the association between handgrip strength and arterial stiffness parameters in hypertensive patients. METHODS: Seventy-two hypertensive patients completed all evaluations and were included in the analysis...
November 8, 2018: Clinical and Experimental Hypertension: CHE
Mona Amin-Beidokhti, Milad Gholami, Atieh Abedin-Do, Reihaneh Pirjani, Hossein Sadeghi, Fatemeh Karamoddin, Vahid Reza Yassaee, Reza Mirfakhraie
BACKGROUND: Preeclampsia is a hypertensive disorder that affects pregnancy, mother, and fetus. Pathogenesis of preeclampsia could be associated with the angiogenesis pathways. The vascular endothelial growth factor (VEGF) family is one of the important factors for normal pregnancy and angiogenesis. Genetic variations in the gene family members may play a role in the etiology of preeclampsia. We investigated the possible association between VEGFA gene rs3025039, and VEGFR1 (FLT1) gene rs722503 polymorphisms and preeclampsia in a sample of Iranian patients...
November 8, 2018: Clinical and Experimental Hypertension: CHE
Toshihiro Kita, Kazuo Kitamura
BACKGROUND AND OBJECTIVE: Seasonal variation of blood pressure (BP) is well known, and a relationship between increases in BP and the incidence of cardiovascular accidents (CVAs) in the winter has been reported. Parameters of arterial stiffness may exhibit seasonal variation; however, available data are currently limited. Novel arterial stiffness indexes, namely the arterial velocity pulse index (AVI) and arterial pressure-volume index (API), can be determined through usual maneuver for BP measurement during the regular examination in the outpatient clinic...
November 8, 2018: Clinical and Experimental Hypertension: CHE
Sang Ho Lee, Steven D Scott, Elizabeth J Pekas, Seungyong Lee, Seok Hoon Lee, Song Young Park
OBJECTIVE: Menopause is associated with a progressive impairment of vascular function and muscular strength in women. Accordingly, the purpose of this study was to determine if Taekwondo training could improve blood catecholamine levels, arterial stiffness, blood pressure (BP) and skeletal muscle strength in postmenopausal women with stage-2 hypertension. METHODS: 20 postmenopausal women (70 ± 4 years old) with stage-2 hypertension were randomly assigned to a 1) Taekwondo training (TT; n = 10) or 2) Control (CON; n = 10) group...
November 2, 2018: Clinical and Experimental Hypertension: CHE
Farahnaz Farzaneh, Zeinab Tavakolikia, Seyed Hosein Soleimanzadeh Mousavi
BACKGROUND: Blood pressure dysfunctions are one of the biggest complications and causes of maternal mortality during pregnancy. The aim of the present study is to evaluate some of the clinical and demographic risk factors in various aspects, both of which can help to better understand the causes and reduce the incidence of preeclampsia. METHOD: This nested case-control study was carried out on 270 pregnant women with preeclampsia as the case group and 270 pregnant women who did not have symptoms of preeclampsia at the time of referral were interviewed according to inclusion criteria as the control group...
November 2, 2018: Clinical and Experimental Hypertension: CHE
Małgorzata Kurpaska, Paweł Krzesiński, Grzegorz Gielerak, Beata Uziębło-Życzkowska, Małgorzata Banak, Katarzyna Piotrowicz, Adam Stańczyk
INTRODUCTION: Arterial hypertension (AH) can lead to the development of heart failure. AIM: Evaluating the relationship between parameters of exercise capacity assessed via a six-minute walk test (6MWT) and cardiopulmonary exercise test (CPET), with a hemodynamic assessment via impedance cardiography (ICG), in patients with AH. METHODS: Exercise capacity was assessed in 98 hypertensive patients (54.5 ± 8.2 years) by means of oxygen uptake (VO2 ) get from CPET, 6MWT distance (6MWTd) and hemodynamic parameters measured by ICG: heart rate (HR), stroke volume (SV), cardiac output (CO)...
October 31, 2018: Clinical and Experimental Hypertension: CHE
Ling-Hui Tang, Cheng Huang, Ying-Qing Feng
OBJECTIVES: Bilirubin has been demonstrated to be linked with anti-inflammatory and antioxidant progress. We aimed to evaluate the association between serum total bilirubin level and carotid intima-media thick-ness (cIMT) in patients with prehypertension. METHODS: We consecutively enrolled pre-hypertensive patients from a community in Guangzhou between January 2017 and January 2018. All patients underwent carotid artery ultrasonography measurement. The correlation between serum total bilirubin and cIMT was assessed by using the Pearson's correlation coefficient...
October 30, 2018: Clinical and Experimental Hypertension: CHE
Kazuo Kobayashi, Masao Toyoda, Moritsugu Kimura, Nobuo Hatori, Takayuki Furuki, Hiroyuki Sakai, Masahiro Takihata, Tomoya Umezono, Shun Ito, Daisuke Suzuki, Hiroshi Takeda, Akira Kanamori, Hisakazu Degawa, Hareaki Yamamoto, Hideo Machimura, Atsuko Mokubo, Keiichi Chin, Mitsuo Obana, Toshimasa Hishiki, Kouta Aoyama, Shinichi Nakajima, Shinichi Umezawa, Hidetoshi Shimura, Togo Aoyama, Kazuyoshi Sato, Masaaki Miyakawa
Decrease in blood pressure contributes to the reno-protective effects of sodium-glucose cotransporter 2 inhibitors; however, its relationship with home monitoring of blood pressure is unclear. We retrospectively analyzed 101 visiting members of the Kanagawa Physicians Association with type 2 diabetes mellitus and chronic kidney disease who were taking sodium-glucose cotransporter 2 inhibitors and who monitored blood pressure at home for a median treatment period of 14 months. At baseline, the mean value of HbA1c was 59...
October 29, 2018: Clinical and Experimental Hypertension: CHE
Xiaoqiang Yin, Jin Qian, Yang Wang, Chuang Yang, Benli Jia, Yunsheng Cheng, Gang Yu, Yong Wang
Bariatric surgery has been used to reduce weight and shown to be beneficial for hypertension control. However, little is known about the changes in blood pressure in early stage after laparoscopic sleeve gastrectomy (LSG). We conducted a prospective study of 60 LSG patients with one year-follow-up. The blood pressure of the patients was measured preoperatively and from day 1 to 12 months postoperatively. The use of antihypertensives, body weight, ghrelin and leptin levels were also recorded. Following LSG, excess weight loss (EWL) was 72...
October 29, 2018: Clinical and Experimental Hypertension: CHE
Chengxin Gong, Xingzi Liu, Lu Ding, Yuanyuan Liu, Tao Li, Shuo Wang, Jiani Zhao, Shenqiang Rao, Chaopeng Xiong, Yuping Yang, Chaxian Liu, Shangdong Liang, Hong Xu
No abstract text is available yet for this article.
October 25, 2018: Clinical and Experimental Hypertension: CHE
Lihua Hu, Xiao Huang, Chunjiao You, Huihui Bao, Wei Zhou, Juxiang Li, Ping Li, Yanqing Wu, Qinghua Wu, Zengwu Wang, Runlin Gao, Qian Liang, Xiaoshu Cheng
OBJECTIVES: This study aimed to assess the relationship of sleep duration on workdays and non-workdays with BP components [systolic BP (SBP), diastolic (DBP), pulse pressure (PP), and mean arterial pressure (MAP)] among Chinese hypertensive adults. METHODS: The study included 3,376 hypertensive patients without antihypertensive treatment. Self-reported sleep durations on workdays and non-workdays were measured by the questionnaire. Multiple linear regression analyses were performed to evaluate the association of sleep duration with BP components...
October 22, 2018: Clinical and Experimental Hypertension: CHE
J R Dash, S K Mishra, S Parida, T U Singh, S Choudhury, K Muniyappa
AIM: Role of TRPV4 channel in regulation of endothelial function in the carotid artery in deoxycorticosterone acetate (DOCA) model of hypertension in rat was studied. METHODS: 8-10 weeks old albino Wistar rats divided into three groups namely Control, UNX and hypertensive animals. Vascular smooth muscle response was studied in isolated carotid artery of rat with acetylcholine, sodium nitroprusside, GSK1016790A (GSK) in presence and absence of L-NAME and indomethacin...
October 16, 2018: Clinical and Experimental Hypertension: CHE
Lu-Xi Zou, Ling Sun
BACKGROUND: Intradialytic hypertension (IDH) is emerging as an important issue in maintenance hemodialysis (MHD) patients. This study aimed to discuss potential factors related to IDH and build forecasting models for post-dialysis blood pressure (BP) in MHD patients with IDH. METHODS: A total of 266 MHD patients were enrolled, included 133 (50%) patients with IDH and 133 patients without IDH. The BP and pulse were determined and recorded over six consecutive dialysis treatments...
October 16, 2018: Clinical and Experimental Hypertension: CHE
Gee Hee Kim, Jung Sun Cho, Woo-Baek Chung, Chan Seok Park, Sang Hyun Ihm
Left atrial (LA) strain is known to exhibit an early progressive reduction in hypertensive patients with diastolic dysfunction. However, an association of the renin-angiotensin-*aldosterone system (RAAS) with LA deformation has not been found in these patients. We aimed to investigate the association of plasma aldosterone concentration (PAC) and 24-hour ambulatory blood pressure monitoring (ABPM) with LA and left ventricle (LV) deformation in never-treated early hypertensive patients. This cross-sectional study included 101 never-treated subjects who were registered in a working group at The Catholic University of Korea...
October 12, 2018: Clinical and Experimental Hypertension: CHE
Mo-Li Zhu, Rui-Li Sun, He-Yun Zhang, Fan-Rong Zhao, Guo-Pin Pan, Chong Zhang, Ping Song, Peng Li, Jian Xu, Shuangxi Wang, Ya-Ling Yin
BACKGROUNDS AND AIMS: Increased arterial stiffness may increase cardiovascular morbidity and mortality. Angiotensin II type 1 receptor blockers (ARBs) are potentially useful in controlling the central blood pressure and arterial stiffness in mild to moderate essential hypertension, while the effects of ARBs in aged patients with essential hypertension are not entirely investigated. METHODS: The carotid-femoral arterial pulse wave velocity (PWV) was measured in aged patients with essential hypertension...
October 12, 2018: Clinical and Experimental Hypertension: CHE
June Wang, Jie Ruan, Man Zhu, Jiayi Yang, Shenlin Du, Peipei Xu, Zheng Zhang, Ping Wang, Weiqing Yang, Mingxia Yu
BACKGROUND: LncRNAs play an essential role in a variety of diseases. Zinc finger antisense 1 (ZFAS1), a newly identified lncRNA, is a transcript antisense to the 5' end of the gene Znfx1. The purpose of this study was to aim to compare the levels of ZFAS1 between ischemic stroke (IS) and healthy control subjects and explore its potential role as a noninvasive biomarker in the diagnosis of IS. METHODS:  A total of 176 patients and 111 healthy controls were included in the study...
October 11, 2018: Clinical and Experimental Hypertension: CHE
Baoxin Li, Qi Yao, Shuqin Guo, Shuang Ma, Yuehua Dong, Huanhuan Xin, He Wang, Lifang Liu, Wenlong Chang, Yunliang Zhang
The incidence of hypertension and diabetes is increasing, it is reported that adipocytokines might be involved in the pathogenesis of diabetes and hypertension. We aimed to investigate the features of adipocytokines, included of Leptin, Irisin, LGR4, and Sfrp5 in type 2 diabetes mellitus (T2DM) patients with hypertension, simultaneously analyzed the connection of the alteration of adipocytokines with blood pressure and glucose. 424 patients with T2DM and 90 healthy subjects were included in the study. The patients with T2DM were divided into 4 groups based on the blood pressure...
October 11, 2018: Clinical and Experimental Hypertension: CHE
Mariyana Hristova, Spaska Stanilova, Lyuba Miteva
BACKGROUND: Renin-angiotensin system (RAS) is a complex network of enzymes and peptides with the essential role in blood pressure control. The relationships between RAS components, RAS-related genetic polymorphisms and therapy response in essential hypertension (EH) were widely explored but the results were inconclusive. AIM: The aim of this study was to explore the functional role of ACE insertion/deletion (I/D) polymorphism on the systemic quantity of angiotensin-converting enzyme (ACE), its homolog - ACE2, chymase and angiotensin II in EH patients with respect to achieved therapeutic blood pressure control...
October 11, 2018: Clinical and Experimental Hypertension: CHE
Matthieu Hein, Jean-Pol Lanquart, Gwenolé Loas, Philippe Hubain, Paul Linkowski
BACKGROUND: Since few studies have investigated the risk of high blood pressure associated with objective insomnia and self-reported insomnia complaints in major depression, the aim of this study was to examine this risk in a large sample of individuals with major depression. METHODS: Data from 703 individuals with major depression recruited from the research database of the sleep laboratory of the Erasme Hospital were analysed. High blood pressure status was defined by the presence of one of the following: self-reports at interview of either a physician-diagnosis or taking antihypertensive medication; or an average systolic blood pressure ≥140 mmHg or an average diastolic blood pressure ≥90 mmHg during at least two medical examinations...
October 10, 2018: Clinical and Experimental Hypertension: CHE
Jingru Lin, Rui Xu, Lin Yun, Yamin Hou, Chan Li, Ying Lian, Fei Zheng
Backgroud: While numerous risk factors for renal damage in the hypertensive population have been reported, there is no single prediction model. The purpose of this study was to develop a model to comprehensively evaluate renal damage risk among hypertensive patients. Methods: We analyzed the data of 582 Chinese hypertensive patients from 1 January 2013 to 30 June 2016. Basic patient information was collected along with laboratory test results. According to the albumin-to-creatinine ratio, the subjects were divided into a hypertension with renal damage group and a hypertension without renal damage group...
October 9, 2018: Clinical and Experimental Hypertension: CHE
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