Read by QxMD icon Read

Clinical and Experimental Hypertension: CHE

Jessica Edith Rodríguez, Rodrigo Romero-Nava, Aldo Arturo Reséndiz-Albor, Erika Rosales-Cruz, Enrique Hong, Fengyang Huang, Santiago Villafaña
Hypertension and diabetes are multifactorial diseases that frequently coexist and exacerbate each another. During the development of diabetes, the impairment of noradrenergic and renin-angiotensin systems has been reported in the response mediated by α1-AR and AT1 receptors. Although their participation in the development of cardiovascular complications is still controversial, some studies have found increased or diminished response to the vasoconstrictive effect of noradrenaline or angiotensin II in a time-dependent manner of diabetes...
2017: Clinical and Experimental Hypertension: CHE
Xiaoyan Fang, Cuizhen Pan, Yongle Chen, Minmin Sun, Zhuojun Zhang, Lindi Jiang, Xiaolin Wang, Xianhong Shu
OBJECTIVE: To evaluate the effect of hyperuricemia (HU) on subclinical changes of left ventricle (LV) function and structure in patients with hypertension (HT) using three-dimensional speckle-tracking echocardiography (3DSTE) and to explore the relationships between serum uric acid (SUA) levels and three-dimensional speckle tracking echocardiography (3DSTE) parameters in hypertensive and nonhypertensive patients with HU. METHODS: Four age- and sex-matched groups were studied: I: healthy controls, HT- HU- (n = 40); II: HT- HU+ (n = 40); III: HT+ HU- (n = 40); IV: HT+ HU+ (n = 44)...
2017: Clinical and Experimental Hypertension: CHE
Giovanna Ricci, Isabel Pirillo, Daniele Tomassoni, Ascanio Sirignano, Iolanda Grappasonni
: Metabolic syndrome (MetS) is a common and complex disorder combining hypertension, obesity, dyslipidemia, and insulin resistance. MetS represents a risk factor for changes in cognitive functions in older age, and several studies have suggested that MetS may be linked to dementia. This article reviews the main evidences about the relationship between MetS and neurodegenerative disease. Starting from an epidemiological point of view, the article analyzes medico-social aspects related to MetS, considering the reduction of work capacity and the condition of disability that it involves...
2017: Clinical and Experimental Hypertension: CHE
Weiwei Zhu, Jing Li, Xipeng Sun, Qi Hua
Several recent studies showed that C825T polymorphism is related to cardiovascular diseases in normal population. However, studies on whether 825T allele influences the incidence of cardiovascular diseases in hypertensive patients are rare. In the current study, 729 patients (CC, n = 332; CT, n = 313; TT, n = 84) with essential hypertension were genotyped for C825T polymorphism of the GNB3 gene and followed 8 years for major adverse cardiovascular events (MACEs) which include stroke, the onset of coronary artery disease (CAD), and all-cause death...
2017: Clinical and Experimental Hypertension: CHE
Xiaojie Li, Yuhan Lin, Hongyu Zhou, Yao Li, Aimei Wang, Hongxin Wang, Ming-Sheng Zhou
Puerarin, a major isoflavonoid compound from Chinese herb Kudzu roots, has been widely used for the treatment of hypertensive and cardiovascular diseases in China. Here, we investigated puerarin's beneficial effects on the cardiovascular system in angiotensin (Ang) II-induced hypertensive rats. Sprague-Dawley rats were treated with Ang II for 5 days or with puerarin for 10 days followed by Ang II and puerarin for 5 days. Endothelium-dependent relaxation (EDR) to acetylcholine was determined using an organ chamber bath...
2017: Clinical and Experimental Hypertension: CHE
Muslima Ejaz, Ejaz Ahmed, Muhammed Mubarak, Juanita Hatcher, Tazeen Jaffar
BACKGROUND: Hypertension is a major public health problem worldwide and a key factor for chronic kidney disease (CKD). Detection and treatment of CKD is of paramount importance. Albuminuria is one of the earliest screening markers recommended in patients at increased risk for CKD. OBJECTIVE: We conducted this study to determine the prevalence of persistent albuminuria (PA) in newly diagnosed hypertensive subjects and to study its associated risk factors. METHODS: A total of 173 (72%) of 240 subjects among 1340 newly diagnosed hypertensive subjects from an ongoing community-based cohort study who had been screened once for the presence of albuminuria were retested for the presence of PA in this study...
2017: Clinical and Experimental Hypertension: CHE
Dan Huang, Jie Zhou, Diansan Su, Weifeng Yu, Jie Chen
BACKGROUND: Impaired baroreflex sensitivity (BRS) is a marker of autonomous dysfunction, which may play an important role in the long-term development of hypertension. Perioperative patients with hypertension are rapidly increasing in all populations worldwide. OBJECTIVE: To estimate the value of BRS for hypertension in a surgery cohort. METHODS: An observational and cross-sectional study was performed, involving 96 patients who underwent video-assisted thoracoscopic pulmonary lobectomy or segmentectomy...
2017: Clinical and Experimental Hypertension: CHE
Yog R Ahuja, Sanjeev Sharma, Vasavi Mohan
Several association studies have been carried out to elucidate the role of genetic variants in cardiovascular diseases (CVDs), while studies on the epigenome regulating gene expression changes are helping to understand the development of disease and factors promoting such changes. This review summarizes the different epigenetic aspects involved in cardiac development and disease along with current therapeutic interventions.
2017: Clinical and Experimental Hypertension: CHE
Xue Bao, Ge Meng, Qing Zhang, Li Liu, Hongmei Wu, Huanmin Du, Hongbin Shi, Yang Xia, Xiaoyan Guo, Xing Liu, Peipei Han, Renwei Dong, Xiuyang Wang, Chunlei Li, Qian Su, Yeqing Gu, Liyun Fang, Fei Yu, Huijun Yang, Li Kang, Yixuan Ma, Bin Yu, Xinyu Ma, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Qi Guo, Kun Song, GuoLin Wang, Guowei Huang, Kaijun Niu
Prehypertension is a public health epidemic associated with various adverse outcomes, but can be reversed by timely intervention. However, little attention has been paid to prehypertension. Complement C3 is a central hub of complement-related immune system. We examined the association between C3 and prehypertension in an adult population for the first time, aiming to investigate whether pro-inflammatory immune response is involved in the prehypertensive state. About 7820 Tianjin residents without hypertension were categorized into sex-specific quintiles based on their serum concentration of complement C3...
2017: Clinical and Experimental Hypertension: CHE
Hua Gao, Yuqing Cheng, Liguo Zong, Linian Huang, Chenchen Qiao, Wei Li, Beilei Gong, Junfeng Hu, Haitao Liu, Xiaojing Wang, Chengling Zhao
This study aimed to investigate the therapeutic effects of aspirin (ASA) and its potential mechanisms of action in monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in rats. PAH was induced in a rat model by a single intraperitoneal (IP) injection of MCT. Saline was injected in a control group. Two weeks following MCT injection, right ventricular systolic pressure (RVSP) and systolic blood pressure (SBP) were measured in six rats from each group to confirm establishment of a PAH model. The remaining MCT-treated rats were randomly allocated to receive IP injection of saline, ASA, or ERK1/2 inhibitor PD98059...
2017: Clinical and Experimental Hypertension: CHE
Natalia Veronez da Cunha, Fernanda Novi Cortegoso Lopes, Carolina Panis, Rubens Cecchini, Phileno Pinge-Filho, Marli Cardoso Martins-Pinge
It has been suggested that nitric oxide (NO) from iNOS source is involved in inflammation and oxidative stress, and hypertension in obese subjects involves an inflammatory process. However, no study evaluated the participation of iNOS inhibition on cardiovascular, autonomic, and inflammatory parameters in obese rats. Obesity was induced by the administration of 4 mg/g body weight of monosodium glutamate (MSG) or equimolar saline (CTR) in newborn rats. On the 60th day, treatment with aminoguanidine (Amino, 50 mg/kg), an iNOS inhibitor, or 0...
2017: Clinical and Experimental Hypertension: CHE
Yuko Ohta, Yorio Kimura, Chie Kitaoka, Tomoko Sakata, Isao Abe, Yuhei Kawano
The purpose of the present study was to investigate blood pressure (BP) control and salt intake in hypertensive outpatients treated at a general hospital and to examine the relationship between their lifestyles and amount of salt intake. Subjects comprised 429 hypertensive patients (206 males, 223 females, and average age of 71 ± 11 years). We estimated 24-hour salt excretion using spot urine samples and assessed lifestyle using a self-description questionnaire. Average clinic BP and the number of antihypertensive drugs were 132 ± 11/73 ± 8 mmHg and 1...
2017: Clinical and Experimental Hypertension: CHE
Jine Xu, Kai Chen, Aiqin Li, Mingzhen Guo, Jingli Wang, Shiguo Liu, Xiuhai Wang
OBJECTIVE: We investigated whether the CXCL12-801G/A polymorphism was associated with preeclampsia (PE) susceptibility in a Chinese Han population. METHODS: We examined 912 PE women and 1025 controls for the CXCL12-801G/A polymorphism by polymerase chain reaction (PCR) and correlations with clinical characteristics were examined. RESULTS: No significant differences in genotypic and allelic frequencies of CXCL12-G801A were found between cases and controls (genotype: χ(2) = 2...
2017: Clinical and Experimental Hypertension: CHE
Raphael Martins Cunha, José Vilaça-Alves, Marcelo Vasconcelos Noleto, Juliana Sá Silva, Andressa Moura Costa, Christoffer Novais Farias Silva, Thaís Inácio Rolim Póvoa, Alexandre Machado Lehnen
Water aerobics exercise is widely recommended for elderly people. However, little is known about the acute effects on hemodynamic variables. Thus, we assessed the effects of a water aerobic session on blood pressure in hypertensive elderly women. Fifty hypertensive elderly women aged 67.8 ± 4.1 years, 1.5 ± 0.6 m high and BMI 28.6 ± 3.9 kg/m(2), participated in a crossover clinical trial. The experiment consisted of a 45-minute water aerobics session (70%-75% HRmax adjusted for the aquatic environment) (ES) and a control session (no exercise for 45 minutes) (CS)...
2017: Clinical and Experimental Hypertension: CHE
(no author information available yet)
No abstract text is available yet for this article.
2016: Clinical and Experimental Hypertension: CHE
Ryu Kobayashi, Kouichi Tamura, Hiromichi Wakui, Masato Ohsawa, Kengo Azushima, Sona Haku, Kazushi Uneda, Kohji Ohki, Kotaro Haruhara, Sho Kinguchi, Satoshi Umemura
We examined the efficacy of single-pill irbesartan/amlodipine combination-based therapy for 12 weeks in 20 hypertensive chronic kidney disease (CKD) patients, by evaluating self-measured home blood pressure (BP) profile. The single-pill irbesartan/amlodipine combination-based therapy decreased clinic BP and home BP (morning, evening, and nighttime BPs), and improved within-visit clinic BP variability, day-by-day home BP variability (morning and evening), and nighttime home BP variability. Furthermore, the single-pill combination-based therapy reduced albuminuria and exerted improved parameters of vascular function...
2016: Clinical and Experimental Hypertension: CHE
Katsuyuki Ito, Masataka Iwane, Nobuyuki Miyai, Yukiko Uchikawa, Koichi Mugitani, Osamu Mohara, Mitsuru Shiba, Mikio Arita
OBJECTIVE: The prognostic value of an exaggerated exercise systolic blood pressure response (EESBPR) remains controversial. This study was designed to assess whether an EESBPR is associated with the predictor of future blood pressure. METHODS: From an initial population of 1,534 male-subjects with normal BP or no medication who underwent ergometric exercise, 733 subjects (mean age: 41 years old) at baseline to follow-up BP after an average of 10 years were selected...
2016: Clinical and Experimental Hypertension: CHE
Tsuneo Takenaka, Yoichi Ohno, Hiromichi Suzuki
BACKGROUND: Kidney resistive index (RI) correlates with tubulointerstitial changes and predicts renal prognosis. Most patients with chronic kidney diseases (CKDs) manifest high blood pressure and atherosclerotic cardiovascular diseases. In addition, various atherosclerotic indexes relate to variations in blood pressure. METHODS: Subjects were 70 CKD patients, who visited our office and agreed to measure home blood pressure and receive renal ultrasonography. Cross-sectional analyses were performed...
2016: Clinical and Experimental Hypertension: CHE
Satoshi Kurisu, Hiroki Ikenaga, Noriaki Watanabe, Tadanao Higaki, Takashi Shimonaga, Ken Ishibashi, Yoshihiro Dohi, Yukihiro Fukuda, Yasuki Kihara
BACKGROUND: Some electrocardiographic indexes such as Cornell index, Cornell product index, or Sokolow-Lyon index remain to be used in the clinical setting. We assessed the effects of body mass index (BMI) on the correlations between these ECG indexes and left ventricular mass (LVM). METHODS: One hundred ninety-six outpatients who underwent both ECG and echocardiography on the same day were included in this study. In accordance with the World Health Organization (WHO) classification of BMI, the patients were classified into the four groups: underweight (<18...
2016: Clinical and Experimental Hypertension: CHE
Shinichiro Fujishima, Tomohiro Takiguchi, Ai Ibaraki, Hirofumi Shimazoe, Risa Hagiwara, Yasuhiro Koyanagi, Eiji Nyuta, Shigeru Kaseda, Tokushi Koga, Takuya Tsuchihashi
The relationship among blood pressure (BP) levels at discharge, other multifaceted factors assessed in cardiac rehabilitation programs, and prognosis for up to 2 years was examined in 154 consecutive cases (132 patients; 69 males; 79 ± 12 years, mean ± SD). A total of 72 composite events occurred (58 rehospitalizations from cardiovascular causes and 14 all-cause death events). The relationship between the systolic BP (SBP) at discharge and the long-term prognosis formed a J-shaped curve, with the event rate being lowest in patients with SBP of 115-125 mmHg...
2016: Clinical and Experimental Hypertension: CHE
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"