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Clinical and Experimental Hypertension: CHE

Tingzhi Deng, Baiqing Ou, Tiangang Zhu, Dingli Xu
OBJECTIVES: To determine whether hypertension (HTN) affects cardiac structure and function in different types of hypertrophic cardiomyopathy (HCM). DESIGN: Patients with obstructive HCM (n = 40), septal HCM (n = 88), and apical HCM (n = 42) were separated into hypertensive and non-hypertensive subgroups, and echocardiographic parameters at baseline and at follow-up were compared between the subgroups. RESULTS: At follow-up, hypertensive obstructive HCM patients showed a decrease in end-diastolic volume (from 93...
July 9, 2018: Clinical and Experimental Hypertension: CHE
Min Liu, Qinghua Han, Jinglu Yang
Recent evidence suggests that elevated plasma levels of Trimethylamine-N-oxide (TMAO) can prolong the duration of elevated blood pressure in rats. The purpose of this study was to investigate the plasma TMAO level in Spontaneously Hypertensive Rats (SHR) and to explore the possible relationship between TMAO and aquaporin-2 (AQP-2) in the formation of hypertension. Twelve-week-old, male Spontaneously Hypertensive rats (SHR, n = 40) and Wistar-Kyoto rats (WKY, n = 40) were accordingly grouped into SHR group and WKY group...
July 9, 2018: Clinical and Experimental Hypertension: CHE
Minghui Bao, Jun Cai, Xinchun Yang, Wenjun Ma
PURPOSE: Bartter syndrome (BS) and Gitelman syndrome (GS) are hereditary diseases characterized by hypokalemia with decreased or normal blood pressure (BP). However, BS or GS patients who present with elevated BP levels have been increasingly reported recently. Therefore, this study aimed to investigate the presence of BS and GS among individuals with unexplained hypokalemia with hypertension in a clinical setting. METHODS: Patients presented with unexplained hypertension and hypokalemia admitted to Hypertension Center of Fuwai Hospital from November 2015 to February 2017 were enrolled...
June 28, 2018: Clinical and Experimental Hypertension: CHE
True Consortium
BACKGROUND: Although inaccurate, non-reproducible blood pressure values can result from non-standardized assessments, recommended approaches to standardize blood pressure measurement are often not followed in research studies. METHODS: An expert consensus of national and international health and scientific organizations developed recommended minimum standards for assessing blood pressure in research subjects where: 1) blood pressure or hypertension is a major endpoint, or 2) blood pressure is likely a major mediator of the research outcome...
June 28, 2018: Clinical and Experimental Hypertension: CHE
Kimika Arakawa, Ai Ibaraki, Yuki Kawamoto, Mitsuhiro Tominaga, Takuya Tsuchihashi
Seasonal winter-summer variation in blood pressure (BP) has been reported, but there are few reports on the reduction of antihypertensive medication during the summer. We aimed to investigate the prevalence and details of drug reduction during the summer among outpatients. Among 667 patients, 90 patients (13.5%) had their medication reduced during the summer. The highest rate of drug reduction was for diuretics (17.5%). The patients whose medications were reduced (Group R) took a larger number of drugs and more frequently took diuretics compared with the subjects whose medications were unchanged (N = 559; with no reduction or increase in drugs, Group UC)...
June 25, 2018: Clinical and Experimental Hypertension: CHE
Lei Zhao, Wei Sun, Junnan Wang, Junduo Wu, Yangyu Zhang, Yingyu Liu, Bin Liu
BACKGROUND: Hypertension is a significant global public health problem and an important risk factor for cardiovascular diseases. We aimed to determine treatment and control rates of hypertension and to explore related risk factors by urban and rural areas. METHODS: A cross-sectional survey of 14,956 participants (≥ 15 years) was conducted in Jilin Province, China from July 2014 to December 2015 using questionnaire forms and physical measurements. RESULTS: Total rates of hypertension treatment, control, and controlled blood pressure among treated subjects were 31...
June 25, 2018: Clinical and Experimental Hypertension: CHE
Xiaochen Yuan, Qingbin Wu, Fei Shang, Bingwei Li, Mingming Liu, Bing Wang, Youming Sheng, Honggang Zhang, Ruijuan Xiu
This work was aimed to study skin blood perfusion, vasomotion and vascular responses of the Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) in different stages of age using spectral. Laser-Doppler flowmetry (LDF) was used to examine the ears and limbs of WKY (12 and 48 weeks old) and SHR (12 and 48 weeks old). The skin blood flow oscillations (SBFOs) were studied by wavelet spectral analysis of LDF tracings. Then, we observed that old groups showed decreased perfusion and SBFO in the ears of both SHR and WKY...
June 25, 2018: Clinical and Experimental Hypertension: CHE
Hiroki Matsuoka, Seiko Miyata, Nozomi Okumura, Takuya Watanabe, Katsunori Hashimoto, Miki Nagahara, Kazuko Kato, Sayaka Sobue, Kozue Takeda, Masatoshi Ichihara, Takashi Iwamoto, Akiko Noda
PURPOSE: Hypertension is an important risk factor for death resulting from stroke, myocardial infarction, and end-stage renal failure. Hydrogen (H2 ) gas protects against many diseases, including ischemia-reperfusion injury and stroke. The effects of H2 on hypertension and its related left ventricular (LV) function have not been fully elucidated. The purpose of this study was to investigate the effects of H2 gas on hypertension and LV hypertrophy using echocardiography. METHODS: Dahl salt-sensitive (DS) rats were randomly divided into three groups: those fed an 8% NaCl diet until 12 weeks of age (8% NaCl group), those additionally treated with H2 gas (8% NaCl + H2 group), and control rats maintained on a diet containing 0...
June 14, 2018: Clinical and Experimental Hypertension: CHE
Eun Ho Choo, Kyoung Hwa Ha, Seung-Won Lee, Hyeon Chang Kim, Sungha Park, Hae Young Lee, Sang-Hyun Ihm
BACKGROUND: Plasma renin activity is involved in the regulation of body salt content and blood pressure. However, there is a paucity of data regarding the association between low or high plasma renin activity and the development of hypertension. METHOD: We investigated the relation of baseline plasma renin activity to increases in blood pressure and the incidence of hypertension after four years in 2,146 non-hypertensive individuals from a community-based Korean population (mean age, 50 years), 58% of whom were women...
June 14, 2018: Clinical and Experimental Hypertension: CHE
Dewei An, Jin Zhang, Xiaofeng Tang, Pingjin Gao, Yan Li, Yan Wang, Dingliang Zhu
BACKGROUND AND AIMS: Genetic factors play an important role in the cervico-cerebral large-artery atherosclerotic stenosis (LAS), and ATP2B1 gene has been associated with the process of atherosclerosis disorders, such as coronary artery disease and arterial stiffness. But there is little information about the relationship between ATP2B1 gene and atherosclerosis in the intracranial arteries. We hereby investigated the association of common variants in ATP2B1 gene with LAS in asymptomatic Chinese hypertension patients...
June 14, 2018: Clinical and Experimental Hypertension: CHE
Borja Jurio-Iriarte, Peter H Brubaker, Ilargi Gorostegi-Anduaga, Pablo Corres, Aitor Martinez Aguirre-Betolaza, Sara Maldonado-Martin
The study aimed to assess whether the Modified Shuttle Walk Test (MSWT) can detect changes in cardiorespiratory fitness (CRF) in overweight/obese people with hypertension (HTN) after an exercise intervention evaluating the equation presented in the previous research by Jurio-Iriarte et al. Participants (N= 248) performed a peak cardiorespiratory exercise test (CPET) and MSWT before and after 16-weeks of different types of aerobic exercise intervention. The formula of Jurio-Iriarte et al. was used to predict peak oxygen uptake (V̇O2peak )...
June 14, 2018: Clinical and Experimental Hypertension: CHE
Fan Wu, Jieli Huang, Jianhong Zhou
Adiponectin protects against the development of albuminuria in rodent experiments and patients with diabetic kidney disease. However, it is not clear whether higher circulating adiponectin levels have the same effect in patients with pregnancy-induced hypertension (PIH). Urine albumin excretion (UAE) is an easy to use test and a powerful index for routine management of PIH patients. This study aimed to investigate the relationship between serum total adiponectin and UAE in PIH patients. A total of 156 PIH patients were enrolled and divided into three groups according to adiponectin tertiles...
June 12, 2018: Clinical and Experimental Hypertension: CHE
Gülsüm Özkan, Sonat Pınar Kara, Çiğdem Fidan, Savaş Güzel, Şükrü Ulusoy
BACKGROUND: Hypertension is a widespread disease involving frequent thrombotic complications. Blood pressure variability (BPV) has recently been shown to be associated with end-organ damage and cardiovascular events. However, the pathogenesis of the relation between BPV and cardiovascular events has not yet been explained. Soluble endothelial protein C (sEPCR) exhibits a procoagulant effect by reducing the anticoagulant and anti-inflammatory effects of protein C and activated protein C...
May 31, 2018: Clinical and Experimental Hypertension: CHE
Jianling Li, Qiaoling He, Qingjie Li, Rongjie Huang, Xiaoyan Wei, Xiaofeng Pan, Weifeng Wu
To determine whether the sympathetic nerve plays a role in the regulation of Na+ -H+ exchange (NHE) in the kidney of spontaneously hypertensive rats (SHR), we investigated the expression of NHE and NHE regulatory protein family (NHERF) in the denervated kidneys compared with intact kidneys. Twelve-week-old male SHR and age-matched Wistar Kyoto (WKY) rats were used. SHR were randomly assigned to the renal denervated (RDNX, n = 8) or Sham (n = 8) groups. The protein and mRNA expression of NHE1, NHE3, NHERF1 and NHERF2 were assessed in the kidney of the groups...
May 22, 2018: Clinical and Experimental Hypertension: CHE
Xiaojun Zhou, Jin Wang, Yunzhi Fa, Huahu Ye
Chlorocebus aethiops sabaeus, the African Green monkey (AGM), has been proved to exhibit renal vascular remodeling and spontaneous hypertension. However, little is known about the roles of microRNAs (miRNAs) in this process.Using small RNA deep sequencing, we compared the plasma miRNA expression patterns between hypertensive (HT) AGMs and normotensive (NT) AGMs. Expression of miRNAs (miR-122, miR-339, miR-296-5p) was validated independently in plasma samples from 10 HT AGMs and 10 NT AGMs (fold changes are 2...
May 22, 2018: Clinical and Experimental Hypertension: CHE
Tian Shen, Jiwei Wang, Yingjun Yu, Jinming Yu
This study aimed to compare the real-world effectiveness of valsartan and non renin-angiotensin system (non-RAS) agent monotherapy on the incidence of new on-set diabetes (NOD) in Chinese hypertensive patients. It was based on an electronic Health Recording System database from Minhang District of Shanghai. Hypertensive patients aged ≥18 years continuously taking either valsartan or non-RAS agent monotherapy for >12 months were included. Hazard ratios (HR) of NOD events were estimated using propensity score matching method and multivariate regression...
May 21, 2018: Clinical and Experimental Hypertension: CHE
Jing Geng, Zhuo Zhao, Le Yang, Mingwei Zhang, Xiangjuan Liu
The present study was designed to determine the role of PKD in vascular remodeling (VR) in Spontaneously hypertensive rats (SHRs). Increased SBP, VR and PKD activation were prominent in SHRs. The SBP has a positive correlation with the activation of PKD in SHRs. The ratio of media to lumen (MT/LD), volume fraction of collagen (VFC), hydroxyproline, IL-6, TNF-α and nitrotyrosine content were significantly related to the activated PKD. It may be concluded that PKD plays a central role in VR, and the mechanism may be related to its regulation of hypertrophy, fibrosis, inflammation and oxidative stress...
May 21, 2018: Clinical and Experimental Hypertension: CHE
Takayuki Ishida, Akinori Oh, Shinzo Hiroi, Yukio Shimasaki, Takuya Tsuchihashi
In 2014, the Japanese Society of Hypertension (JSH) issued revised guidelines for hypertension management. To assess adherence to the guidelines, this retrospective study evaluated the real-world status of antihypertensive drug prescribing for Japanese patients with hypertension, classified by comorbidity: diabetes mellitus, dyslipidemia, gout/hyperuricemia and renal diseases. Data on 59,867 hypertensive patients who received their first prescription for antihypertensive therapy between April 2014 and March 2015, were obtained from a medical insurance claims database for hospitals participating in the Diagnosis Procedure Combination/Per-Diem payment system...
May 21, 2018: Clinical and Experimental Hypertension: CHE
Sang Woong Park, Kyung Chul Shin, Soon-Kyu Yoou, Hyun Ji Park, Seo Hyeon Eun, Young Min Bae, Hyang Mi Lee, Han-Jung Chae, Soo-Wan Chae, Bok Hee Choi
Mulberry (Morus alba) has been used in traditional oriental medicine since ages. Recently, it has been reported that mulberry produces hypotensive effects through the eNOS signaling pathway. However, the mechanism underlying the hypotensive effects of mulberry is not entirely clear. Moreover, the effects of mulberry on vascular remodeling events such as hyperplasia, an important etiology in the pathogenesis of hypertension and arteriosclerosis, are also ambiguous. Here, we hypothesized that an ethanolic extract of mulberry fruit (EMF) has beneficial effects on vascular remodeling and produces hypotensive effects...
May 17, 2018: Clinical and Experimental Hypertension: CHE
Farshid Keshavarzi, Mahnaz Shahrakipoor, Batool Teimoori, Minoo Yaghmaei, Mehrnaz Narooei-Nejad, Ava Rasooli, Saeedeh Salimi
BACKGROUND: Preeclampsia (PE), is a pregnancy-specific complication with the placental origin which associated with altered expression of angiogenic factors. Vascular Endothelial Growth Factor (VEGF), is a growth and hypoxia-induced factor which contributes to the regulation of various processes. The present study has investigated the association of the placental VEGF -634G/C (rs2010963), -1154G/A (rs1570360), and -2549 I/D (18bpindel) polymorphisms in the promoter region with VEGF mRNA expression in PE women and control group...
May 17, 2018: Clinical and Experimental Hypertension: CHE
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