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Clinical and Experimental Hypertension: CHE

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https://www.readbyqxmd.com/read/30648895/standardized-ethanol-water-extract-of-ficus-deltoidea-angustifolia-reduces-blood-pressure-in-spontaneously-hypertensive-rats
#1
Mohd Saleh Ahmad Kamal, Nor Hadiani Ismail, Nuraliza Abdul Satar, Norasikin Abdul Azis, Zurain Radjeni, Halimatul Saadiah Mohammad Noor, Noraini Kasim, Harbindarjeet Singh
Ficus deltoidea is used in Malay traditional medicine for the treatment of a number of disorders, including hypertension. There is, however, no scientific evidence on its anti-hypertensive effects. This study, therefore, investigated the effects of a standardized ethanolic-water extract of Ficus deltoidea Angustifolia (FD-A) on blood pressure (BP) in spontaneously hypertensive rats (SHR). Male SHR with systolic BP of >150 were divided into 4 groups (n = 8) and given either FD-A (800 or 1000 mg kg-1 day-1 ) or losartan (10 mg kg-1 day-1 ) or 0...
January 16, 2019: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/30632806/maximum-home-systolic-blood-pressure-is-a-marker-of-carotid-atherosclerosis
#2
Toshiki Kaihara, Satoshi Hoshide, Naoko Tomitani, Hiroshi Kanegae, Kazuomi Kario
BACKGROUND: Maximum home systolic blood pressure (maximum SBP) has been reported as a parameter of blood pressure (BP) variability. We tested the hypothesis that maximum SBP is one of the risk factors of hypertensive target organ damage (TOD). METHODS: We conducted a cross-sectional study of 4,310 subjects with 1 cardiovascular risk factor. The subjects measured their home BP for 14 consecutive days. Mean and maximum SBPs were used as independent variables. As dependent variables, we used left ventricular mass index (LVMI), brachial-ankle pulse wave velocity (baPWV), maximum carotid intima-media thickness (CIMT), and urine albumin creatinine ratio (UACR)...
January 11, 2019: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/30626217/vascular-effects-of-isometric-handgrip-training-in-hypertensives
#3
Sergio L Cahu Rodrigues, Breno Quintella Farah, Gustavo Silva, Marilia Correia, Rodrigo Pedrosa, Lauro Vianna, Raphael M Ritti-Dias
The isometric handgrip training (IHT) has been emerging as an alternative approach for blood pressure (BP) reduction in hypertensive patients. However, the mechanisms underlying the reductions in BP after IHT are poorly known. Thus, the aim of this study was to analyze the vascular effects of IHT in hypertensive patients. A randomized controlled trial was conducted with 33 hypertensive patients (61 ± 2 y.o.; 67% female) who were randomly assigned to two groups: IHT or control group. The IHT group has completed three weekly sessions of isometric handgrip (4 × 2  min sets, alternating the hands at 30% of maximal voluntary contraction)...
January 9, 2019: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/30582370/prospective-single-arm-observational-study-of-human-chymase-inhibitor-polygonum-hydropiper-l-in-subjects-with-hypertension
#4
Keisuke Okamura, Rieko Kuroda, Kaori Nagata, Hidenori Urata
BACKGROUND AND PURPOSE: Human chymase (h-chymase) is a serine protease that forms local angiotensin II and has been proven to be related to onset of hypertension, arteriosclerosis, and post myocardial infarction cardiac remodeling. Since no chymase inhibitor was clinically available, an extensive screening for inhibition of h-chymase in three different extracts (water, hot water,  and ethanol) of approximately 800 food ingredients had been performed and we identified Polygonum hydropiper L (Polygonum)...
December 23, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/30582369/irreversible-effects-of-long-term-chronic-smoking-on-arterial-stiffness-an-analysis-focusing-on-ex-smokers-among-otherwise-healthy-middle-aged-men
#5
Sunwon Kim, Sun Ju Lee, Yong-Hyun Kim, Jin-Seok Kim, Sang-Yup Lim, Seong Hwan Kim, Jeong-Cheon Ahn, Woo-Hyuk Song, Sun Ha Jee, Chang Gyu Park
OBJECTIVE: Smoking is a modifiable cardiovascular risk factor closely related to arterial stiffness (AS). However, data are lacking regarding the chronic effects of smoking on AS, especially in ex-smoker (ES) who faces remnant cardiovascular risk when compared to never-smokers (NS). METHODS: Among 1722 health screening participants, we retrospectively evaluated 652 healthy men with different smoking history [240 current smoker (CS) vs. 228 ES vs. 184 NS]. To assess AS, augmentation index (AIx), pulse pressure amplification (PPamp), and carotid-femoral pulse wave velocity (cfPWV) were measured and compared...
December 23, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/30582364/plasma-leptin-level-is-positively-associated-with-blood-pressure-measures-independent-of-gender-and-bmi
#6
Mohammad Mehdi Ghaedian, Ali Nazari Jaz, Mohsen Momeni, Tahereh Ghaedian, Najmeh Samiei
BACKGROUND: Since the introduction of leptin, many studies suggest an important role for this hormone in obesity-related hypertension. However, in non-obese patients, there are controversial results regarding the possible role of leptin in essential hypertension especially in both sexes and different groups of body mass index (BMI). We aimed to evaluate the association of leptin and hypertension in both female and male gender. MATERIALS AND METHODS: This cross-sectional study was conducted, recruiting 80 essential hypertensive patients and 80 healthy normotensive volunteers using convenience sampling method...
December 22, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/30563368/prevalence-and-factors-associated-with-fast-resting-heart-rate-in-hypertensive-and-normotensive-patients
#7
Xiaofei Li, Tao Kong, Yan Yao, Jingzhou Chen, Kai Sun, Shu Zhang, Rutai Hui, Xiaohan Fan
BACKGROUND: Fast resting heart rate (RHR) is easily neglected in clinical practice of hypertension treatment. AIMS: We aimed to investigate the prevalence of fast RHR and associated factors in hypertensive and normotensive individuals. METHODS: We retrospectively analyzed data from two cross-sectional studies conducted in China. A total of 6763 hypertensive patients and 2807 age and sex-matched normotensive subjects with complete data on resting electrocardiogram and medical history were included...
December 19, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/30561227/association-of-aldosterone-synthase-cyp11b2-344c-t-gene-polymorphism-with-essential-hypertension-and-left-ventricular-hypertrophy-in-the-egyptian-population
#8
Muhammad Tarek Abdel Ghafar
BACKGROUND AND OBJECTIVES: Essential hypertension is a complex progressive cardiovascular disorder. Renin-angiotensin aldosterone system (RAAS) plays a major role in blood pressure regulation. Aldosterone, synthesized in the adrenal cortex by aldosterone synthase is encoded by the CYP11B2 gene. This case-control study was aiming to investigate the relationship between the aldosterone synthase gene (CYP11B2) biallelic polymorphism in the promoter at position -344 (-344C/T) with essential hypertension and left ventricular hypertrophy in the Egyptian population...
December 18, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/30554536/central-aortic-pressure-improves-prediction-of-cardiovascular-events-compared-to-peripheral-blood-pressure-in-short-term-follow-up-of-a-hypertensive-cohort
#9
Junli Zuo, Guili Chang, Isabella Tan, Mark Butlin, Shao-Li Chu, Alberto Avolio
OBJECTIVE: The aim of this study was to assess indices of a comprehensive panel of central aortic pressure and arterial stiffness for prediction of cardiovascular events in a hypertensive cohort. METHODS: Noninvasive measurements of central aortic blood pressure, brachial pressure, wave reflection augmentation index, pressure amplification, pulse wave velocity (PWV) and carotid intima-media thickness (IMT) were obtained in 675 hypertensive patients (age 61 ± 9 years, 425 males) for a mean follow-up period 25 ± 4 months...
December 16, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/30512984/prevalence-and-characteristics-of-apparent-treatment-resistant-hypertension-in-older-people-in-china-a-cross-sectional-study
#10
Cunjin Wu, Yibo Wang, Weili Zhang, Xin Li, Lin Wang, Rutai Hui
The prevalence and associated risk factors of apparent treatment-resistant hypertension (aTRH) in older people in China is unknown. The aim of this study is to investigate the prevalence of aTRH in older people and describe the characteristics of older patients with aTRH. Using two-stage random clustering sampling, 3774 patients with hypertension aged ≥60-75 years were recruited between July 2012 and December 2015. The patients were divided into two groups: aTRH and non-aTRH groups according to their blood pressure (BP) levels, and whether or not they reached goal BP value...
December 4, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/30501425/pulse-wave-velocity-reference-values-in-3-160-adults-referred-to-a-hypertension-clinic-for-24-hour-ambulatory-blood-pressure-monitoring
#11
Dagnovar Aristizábal-Ocampo, Diego Espíndola-Fernández, Jaime Gallo-Villegas
BACKGROUND: Carotid-femoral pulse wave velocity (PWV) is a direct measure of aortic stiffness used in the stratification of cardiovascular risk. Its clinical application in Latin America has been limited by the absence of reference values. The objective of this study was to establish PWV reference values among adults referred to a specialized cardiology center for 24-hour ambulatory blood pressure monitoring (ABPM) in Medellín, Colombia. METHODS: A descriptive study of 3,160 records of adult (older than 18 years) patients without pharmacological treatment assessed for PWV using a Mobil-O-Graph® 24-hour PWA device (IEM, Stolberg, Germany) and 24-hour ABPM with hemodynamic parameters based on suspected hypertension or hypotension was conducted...
December 2, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/30501136/relationship-between-fitness-and-arterial-stiffness-according-to-hypertensive-state
#12
Jidong Sung, Soo Jin Cho, Kyong Pyo Hong
BACKGROUND: There is a well-established relationship between cardiorespiratory fitness (CRF) and arterial stiffness. However, it is unclear whether this relationship differs significantly between hypertensive and non-hypertensive patients. METHODS: Adults without a history of ischemic heart disease or stroke and normal exercise test results who underwent health screening were included. Cardiopulmonary function test was performed using the Bruce protocol. Peak oxygen consumption (VO2peak) was measured...
November 30, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/30497297/performance-of-questionnaires-aimed-at-detecting-sleep-disorders-in-patients-attending-a-hypertension-center
#13
Miguel Schiavone, Glenda Ernst, Magali Blanco, Horacio Avaca, Ana Lucia Acosta, Daniela Nosetto, Osvaldo Manuale, Alejandro Salvado, Eduardo Borsini
INTRODUCTION: Hypertension (HT) and obstructive sleep apnea-hypopnea syndrome (OSA) are prevalent and frequently related pathologies. The predictive value of screening questionnaires in cardiovascular settings is not totally clear and could be useful to select candidates for the sleep test. MATERIALS AND METHODS: We performed a prospective study in adults with suspected HT referred to a day-care hospital. Epworth Sleepiness Scale (ESS), Berlin, and STOP-BANG (SBQ) questionnaire were checked against data from home-based respiratory polygraphy (RP)...
November 29, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/30497286/the-combined-effect-of-serum-cystatin-c-and-dyslipidemia-on-hypertension-in-a-large-health-check-up-population-in-china
#14
Jun Ma, Zewei Wu, Xiaojuan Zha, Xinying Zhu, Wenbo Li, Mingfei Jiang, Shuyi Wang, Shouzhi Wu, Yufeng Wen
OBJECTIVE: Some studies have reported that both serum cystatin C (Cys C) and dyslipidemia are independently associated with hypertension. However, the combined effect of the two factors is still unknown. The present study was aimed at investigating the effect of Cys C combined with dyslipidemia on hypertension in a large health check-up population in China. METHODS: A total of 203 233 health check-up subjects from January 2011 to July 2016 were recruited into this cross-sectional study...
November 29, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/30472896/berberine-suppresses-the-ectopic-expression-of-mir-133a-in-endothelial-cells-to-improve-vascular-dementia-in-diabetic-rats
#15
Sen Yin, Wenwu Bai, Peng Li, Xu Jian, Tichao Shan, Zhenyu Tang, Xuejiao Jing, Song Ping, Quanzhong Li, Zhang Miao, Shuangxi Wang, Wensheng Ou, Jianchun Fei, Tao Guo
OBJECTIVE: Vascular dementia is the second leading cause of dementia, which is strongly associated with diabetes. Ectopic expression of miR-133a in endothelial cells is involved in endothelial dysfunction in diabetes. Whether berberine, as a natural product in Coptis chinensis, improves vascular dementia induced by diabetes remains unknown. METHODS: Diabetes and subsequent vascular dementia were induced in rats by injecting streptozotocin (50 mg/kg/day) for five consecutive days...
November 26, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/30466333/inferred-systolic-blood-pressure-levels-to-switch-from-lifestyle-modifications-to-antihypertensive-medications-a-success-rate-oriented-simulation
#16
Yoichi Ohno, Tsuneo Takenaka, Hiromichi Suzuki
OBJECTIVE: This simulation study attempted to infer the systolic blood pressure (SBP) levels at which subjects with hypertension, health nurses, and primary physicians should switch their preference of their treatment policies from lifestyle modifications to antihypertensive medications in virtual Japanese sample populations. METHODS: We assumed that SBP levels were normally distributed and that the incidence rate of cardiovascular disease (IRCVD , events/year) increased exponentially according to SBP...
November 22, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/30461323/correction
#17
(no author information available yet)
No abstract text is available yet for this article.
November 21, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/30453795/unique-mode-of-binding-between-angiotensin-ii-type-1-receptor-and-its-blockers
#18
Yoshino Matsuo, Yasunori Suematsu, Sayo Tomita, Kohei Tashiro, Takashi Kuwano, Ken Kitajima, Shin-Ichiro Miura
BACKGROUND: We hypothesized that the 5-oxo-1,2,4-oxadiazole moiety of azilsartan (AZL), which represents a small difference in the molecular structures of AZL and candesartan (CAN) [angiotensin II type 1 receptor (AT1 R) blockers], may be responsible for the molecular effects of AZL. METHODS: We examined the binding affinities of AZL and CAN to AT1 R, along with their ability to block receptor activity. A competition binding study, inositol phosphate (IP) production assay and extracellular signal-regulated kinase (ERK) assay were performed using wild-type (WT) and mutants AT1 R-transfected cells...
November 19, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/30451012/long-term-low-salt-diet-increases-blood-pressure-by-activation-of-the-renin-angiotensin-and-sympathetic-nervous-systems
#19
Jialiang Wang, Yi Deng, Xue Zou, Hao Luo, Pedro A Jose, Chunjiang Fu, Jian Yang, Chunyu Zeng
Background The aim of this study was to investigate the effect of long-term low salt diet on blood pressure and its underlying mechanisms. Methods Male Sprague-Dawley (SD) rats were divided into normal salt diet group (0.4%) and low salt diet group (0.04%). Blood pressure was measured with the non-invasive tail-cuff method. The contractile response of isolated mesenteric arteries was measured using a small vessel myograph. The effects on renal function of the intrarenal arterial infusion of candesartan (10 μg/kg/min), an angiotensin II receptor type 1 (AT1 R) antagonist, were also measured...
November 18, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/30409054/association-between-handgrip-strength-and-vascular-function-in-patients-with-hypertension
#20
Dalton de Lima-Junior, Breno Quintella Farah, Antonio Henrique Germano-Soares, Aluísio Andrade-Lima, Gustavo Oliveira Silva, Sergio Luiz Cahu Rodrigues, Raphael Ritti-Dias
BACKGROUND: Increased handgrip strength has been associated with lower cardiovascular and non-cardiovascular mortality in different populations. In patients with hypertension, arterial stiffness relates to cardiovascular mortality. However, whether muscle strength is associated with arterial stiffness in hypertensives is unknown. Thus, the objective of this study was to analyze the association between handgrip strength and arterial stiffness parameters in hypertensive patients. METHODS: Seventy-two hypertensive patients completed all evaluations and were included in the analysis...
November 8, 2018: Clinical and Experimental Hypertension: CHE
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