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Clinical and Experimental Hypertension: CHE

Li Wu, Wanrong Lin, Xian Fu, Xianliang Li, Xuelong Li, Youfu Li, Weijin Zhang, Jian Guo, Qingchun Gao
Researches involving arterial pressure measurements in mice have primarily relied on carotid arterial catheterization. However, in some circumstances, measuring arterial pressure through the carotid arterial impairs accuracy. This study was aimed to evaluate whether femoral artery could displace carotid artery for the blood pressure (BP) measurements in mice. Fifty-six Swiss mice (n = 14 in each group) were randomized into four groups: control, left femoral artery, right femoral artery, and union group, in which BP was measured through left carotid, left femoral, right femoral artery, and simultaneously from right femoral artery and left carotid artery, respectively...
September 10, 2018: Clinical and Experimental Hypertension: CHE
Xiaoman Ye, Jian Jia, Ning Zhang, Haixia Ding, Yiyang Zhan
Vitamin D deficiency can lead to high blood pressure. Polymorphisms in the vitamin D hydroxylase gene have been associated with serum vitamin D levels in some Western countries. The aim of this study was to investigate whether polymorphisms of hydroxylase genes in the vitamin D metabolic pathway contribute to hypertension by affecting serum vitamin D status in a Han Chinese population. We selected four single nucleotide polymorphisms (SNPs; rs1993116 and rs10741657 of CYP2R1; rs4809957 and rs6068816 of CYP24A1) for genotyping in 525 control subjects and 324 hypertensive patients, and detected vitamin D levels in blood in subsets of these groups...
September 7, 2018: Clinical and Experimental Hypertension: CHE
Ramsha Iqbal, Md Sayeed Akhtar, Md Quamrul Hassan, Zeeba Jairajpuri, Mohd Akhtar, Abul Kalam Najmi
Pitavastatin inhibits 3 hydroxy 3 methyl glutaryl coenzyme A (HMGCoA) reductase enzyme, preventing cholesterol synthesis along with elevating high density apolipoprotein A1 (Apo-A1). The present study was designed to evaluate cardioprotective potential of pitavastatin at 1 mg/kg/day and 3 mg/kg/day dose for 14 days in low dose isoproterenol (ISO) (5 mg/kg/day for 7 consecutive days) induced myocardial damage. ISO administration induced significant reduction in endogenous antioxidant enzymes like reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and raised thiobarbituric acid reactive substances (TBARS) indicating activated lipid peroxidation...
September 7, 2018: Clinical and Experimental Hypertension: CHE
Fulvia Gloria-Bottini, M Banci, A Neri, A Magrini, E Bottini
Adenosine modulates cardiovascular functions reducing blood pressure and heart rate. Adenosine deaminase (ADA) by the irreversible deamination of adenosine to inosine contributes to the regulation of adenosine concentration in body fluids. We have studied the interaction between smoking and ADA genetic variability concerning their effects on blood pressure. We have studied 344 subjects admitted to the hospital for cardiovascular diseases. The genotypes of two polymorphic loci within the ADA gene were determined: ADA1 and ADA2 ...
September 7, 2018: Clinical and Experimental Hypertension: CHE
Ying Yang, Hui Luo, Si Liu, Rongyi Zhang, Xiao Zhu, Murong Liu, Houxiang Hu, Yi Yang, Zhan Lv, Mao Chen
Platelets are major sources of microparticles (MPs) in peripheral bloodstream, and platelet-secreted MPs (P-MPs) transfer biological information to neighboring cells. In the present study, we found that the platelet- and P-MPs-derived microRNA-4306 (miR-4306) expression were downregulated in coronary artery disease (CAD) and platelet-derived miR-4306 was an independent poor prognostic factor in CAD. Plasma miRNA-4306 mainly cofractionated with MPs instead of Argonaute2 complexes or HDL. P-MPs could effectively deliver miR-4306 into human monocyte-derived macrophages (HMDMs)...
September 5, 2018: Clinical and Experimental Hypertension: CHE
Brinda Srinivasagopalane, Sanjay Andrew Rajarathinam, Thoppalan Balasubramaiyan
Over the recent years, the pathophysiology of the inflammatory component in hypertension has been a challenge, because this inflammatory response is mainly contributed by an increased oxidative stress with the release of inflammatory mediators. Identification of a simple and early inflammatory marker such as the neutrophil-to-lymphocyte ratio (NLR) is the need of the hour. This study correlates the same specifically taking into account the duration and the grades of hypertension. OBJECTIVE: The response of the NLR among the hypertensives and its correlation with duration and stages of hypertension...
September 5, 2018: Clinical and Experimental Hypertension: CHE
Miao Xu, Jialin Li, Xiaomin Chen, Liyuan Han, Li Li, Yahui Liu
OBJECTIVES: Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) plays an essential role in folate-mediated one-carbon metabolism which determines both homocysteine remethylation and de novo thymidylate biosynthesis. Hyperhomocysteinemia is positively associated with essential hypertension. This study aimed to investigate the association of MTHFD1 promoter methylation with essential hypertension. METHODS: Using the quantitative methylation-specific polymerase chain reaction (qMSP), the levels of MTHFD1 promoter methylation in 243 essential hypertension patients, 218 age- and gender-matched healthy controls...
September 5, 2018: Clinical and Experimental Hypertension: CHE
Ebru Ipek Turkoglu, Emine Cigdem Kircicegi Cıcekdag
BACKGROUND: Resistant hypertension (RHT) is defined as high blood pressure despite three antihypertensive medications one being a diuretic. RHT is a common clinical problem and as a subgroup has not been studied widely. The present study has investigated patient demographics and if the RHT might be a clinical presentation of heart failure with preserved ejection fraction (HFPEF) in elderly. METHOD: The outpatient data between January and June 2015 of Izmir Kemalpasa State hospital's hypertension specialty clinic has been reviewed retrospectively...
September 5, 2018: Clinical and Experimental Hypertension: CHE
Yuanyuan Chen, Fengxia Xue, Cha Han, Huiyun Yang, Lulu Han, Ke Li, Jie Li, Qian Xu, Zengyan Li, Bibo Yuan, Limin Yu, Xiaoli Gao, Ye Yan
Preeclampsia (PE) occurs specifically during pregnancy characterized by new-onset hypertension. The pathogenesis of PE was complicated, and inflammation may be central to the pathogenesis of PE. Ferulic acid (FA) is recognized to prevent cell damage and apoptosis induced by oxidative stress and inflammation. In our study, we used NG-nitro-l-arginine methyl ester (L-NAME)-induced rat model of PE to investigate whether FA improved PE and its possible mechanism. We found that FA significantly reduced blood pressure, urine volume, and urinary protein level in rats with PE...
September 5, 2018: Clinical and Experimental Hypertension: CHE
Xiaojie Yuan, Xiaochun Li, Zhaohua Ji, Jing Xiao, Lei Zhang, Weilu Zhang, Haixiao Su, Kanakaraju Kaliannan, Yong Long, Zhongjun Shao
Evidence for blood pressure-lowering effects of vitamin C (VC) supplementation in clinical trials is inconsistent and limited studies have examined the effect of VC supplementation on hypertension (HTN) control. In this study, eligible patients were cluster assigned to receive 300 mg VC per day or nothing for 6 months. During the 6-month follow-up period, a questionnaire survey was obtained and standardized blood pressure measurements were performed on all subjects. Oral administration of VC significantly decreased the diastolic blood pressure and pulse pressure with a significant increase in HTN control...
September 5, 2018: Clinical and Experimental Hypertension: CHE
Shuting Lu, Shizheng Du, Anne Fish, Cong Tang, Qingqing Lou, Xuefang Zhang
To assess the efficacy and safety of wet cupping in adults with hypertension, we conducted a systematic review and meta-analysis using 13 databases. Wet cupping alone or in combination with antihypertensive medication or acupuncture was used. Seven randomized trials were included, most not of high methodological quality. A few small studies suggested that wet cupping alone versus antihypertensive medication significantly reduced blood pressure and Traditional Chinese Medicine syndrome (hypertension-related symptoms)...
September 5, 2018: Clinical and Experimental Hypertension: CHE
Yuto Hashimoto, Takanobu Okamoto
AIM: Aquatic exercise might improve endothelial function due to hydrostatic pressure increasing blood flow and causing shear stress to the endothelium. However, the acute effect of aerobic exercise in water on endothelial function is unclear. The present study compares the acute effect of aerobic exercise at moderate intensity in water and on land on endothelial function. METHODS: Nine healthy young men walked on a treadmill for 30 min while immersed in water up to the xiphoid at 30...
August 24, 2018: Clinical and Experimental Hypertension: CHE
Hilmi Erdem Sumbul, Ayse Selcan Koc, Derya Demirtas
BACKGROUND: Increased carotid-femoral pulse wave velocity (CF-PWV) and increased carotid intima-media thickness (IMT) in hypertension (HT) patients are indicators of asymptomatic organ damage. The relationship between carotid IMT and CF-PWV has been shown; studies comparing CF-PWV and IMT values within different vascular regions are limited. We aimed to investigate the relationship between IMT value measured from different anatomical regions and CF-PWV, and the localization of IMT that determines increased CF-PWV best...
August 24, 2018: Clinical and Experimental Hypertension: CHE
Chang Eun Park, Hyun Ho Sung, Eun Young Jung, Ae Eun Moon, Han Soo Kim, Hyun Yoon
Hyperuricemia is associated with cardiovascular disease, but the relationship between uric acid (UA) and pulse pressure (PP) is unclear. Therefore, the present study assesses the relationship between UA and PP among Korean adults. Data from 6,310 subjects (2,800 men and 3,510 women) in the seventh Korean National Health and Nutrition Examination Survey (2016) were analyzed. After adjusting for related variables, the odds ratios (ORs) of hyperuricemia (UA ≥ 7.0 mg/dL in men or ≥ 6.0 mg/dL in women) in the high PP group (PP > 65...
August 24, 2018: Clinical and Experimental Hypertension: CHE
Mehmet Fuat Gulhan
BACKGROUND: Hypertension is described as increased blood pressure based on changed hemodynamics and associated with an increased oxidative damage to reproductive function. This work is to determine therapeutic and protective effects of apitherapy products (propolis and pollen) on reproductive functions of L-NAME-induced hypertensive male rats. METHODS: Experimental animals were indiscriminately separated into four groups of seven rats in each group: (I) Control, (II) L-NAME, (III) L-NAME+ propolis and (IV) L-NAME+ pollen...
August 17, 2018: Clinical and Experimental Hypertension: CHE
Udaya Ralapanawa, Nuwan Nanayakkara, Kushalee Poornima Jayawickreme, Noorika Wickramasurendra, Sampath Tennakoon
BACKGROUND: Hypertension (HT) is identified as a highly prevalent cardiovascular risk factor and also as a separate disease entity, leading to significant mortality and morbidity. The rate of HT is increasing worldwide with a faster rate identified in developing countries. Thus, it is important to evaluate epidemiological patterns of chronic HT in a developing country like Sri Lanka. METHODOLOGY: This is a cross-sectional descriptive study conducted at the Teaching Hospital Peradeniya, Sri Lanka, to assess symptoms and risk factors among patients with chronic HT...
August 15, 2018: Clinical and Experimental Hypertension: CHE
Xiao Wu, Bo Li, Wei-Quan Lin, Ling-Ling Huang, Xiao-Xiao Wang, Li-Ying Fu, Bing-Bing Li, Pei-Xi Wang
OBJECTIVE: This study aimed to investigate the most notable obesity index and its optimal cut-off point of hypertension in different age groups stratified by sexes among community residents in southern China. METHODS: In this cross-sectional study, 620 men and 631 women aged 18-59 years were enrolled. The independent-samples t-test and chi-square test were conducted to analyze continuous and categorical variables, respectively. Multivariate logistic regression analysis and receiver operating characteristic (ROC) curve analysis assessed the association between the obesity indices and hypertension risk...
August 10, 2018: Clinical and Experimental Hypertension: CHE
Sung Hoon Kim, Ju Suk Lee
PURPOSE: The establishment of a definitive association between smoking and hypertension has been controversial in previous studies, many of which were based on self-reported smoking status and urine cotinine-verified smoking status. The aim of the current study was to evaluate the association between hypertension and smoking considering the effects of all kinds of smoker types, including hidden smokers, using new variables and a population-based sample. METHODS: Data were acquired from 25,150 men and women aged older than 29 years who participated in the Korea National Health and Nutrition Examination Survey (KNHANES)...
July 30, 2018: Clinical and Experimental Hypertension: CHE
M F Peixoto, Mlr Cesaretti, S D Hood, A Tavares
OBJECTIVE: To test the role of escitalopram on blood pressure and heart rate of individuals with hypertension and depression. METHODS: A total of 30 individuals participated in this study who were being treated for hypertension and were diagnosed with major depression. Escitalopram (10-20 mg) was administered to 15 individuals, while the other 15 received placebo. These individuals were followed for 8 weeks with regular monitoring of blood pressure and heart rate...
July 26, 2018: Clinical and Experimental Hypertension: CHE
Tingzhi Deng, Baiqing Ou, Tiangang Zhu, Dingli Xu
OBJECTIVES: To determine whether hypertension (HTN) affects cardiac structure and function in different types of hypertrophic cardiomyopathy (HCM). DESIGN: Patients with obstructive HCM (n = 40), septal HCM (n = 88), and apical HCM (n = 42) were separated into hypertensive and non-hypertensive subgroups, and echocardiographic parameters at baseline and at follow-up were compared between the subgroups. RESULTS: At follow-up, hypertensive obstructive HCM patients showed a decrease in end-diastolic volume (from 93...
July 9, 2018: Clinical and Experimental Hypertension: CHE
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