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Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne

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https://www.readbyqxmd.com/read/29168977/nlr-and-microalbuminuria-are-these-markers-significantly-associated
#1
Gianfranco E Umeres-Francia, María V Rojas-Fernández, Vicente A Benites-Zapata
No abstract text is available yet for this article.
November 27, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/29168976/biological-therapies-in-psoriasis-revisited
#2
Maria-Isabela Sârbu, Simona-Roxana Georgescu, Mircea Tampa, Alexandra-Elena Sârbu, Olga Simionescu
Psoriasis is a chronic, immune mediated disorder affecting approximately 2% of the population. Even in our days, patients with psoriasis are confronted with stigmatization and social rejection. As a result, their quality of life is significantly impaired. Biological therapies have revolutionized the treatment of moderate to severe psoriasis. The aim of this paper is to look over the most important biological therapies available for the management of plaque-type psoriasis.
November 27, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/29168975/treating-malignant-melanoma-when-a-rare-braf-v600m-mutation-is-present-case-report-and-literature-review
#3
Andrei Popescu, Andrei Haidar, Rodica Maricela Anghel
Recent years have brought major advances in the treatment of malignant melanoma. One such an advance is the treatment with BRAF tyrosine-kinase inhibitors in metastatic malignant melanomas that harbor mutations in the BRAF gene. The trials that have been performed in this setting have demonstrated superior response rates and increased overall survival, however they mostly included patients with melanomas carrying the more common V600E and V600K mutations, not being able to assess the benefit of these treatments in situations where more rare mutations of the BRAF gene are present...
November 27, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/29099692/macrophage-activation-syndrome-associated-with-systemic-lupus-erythematosus-treated-successfully-with-the-combination-of-steroid-pulse-immunoglobulin-and-tacrolimus
#4
Natsuki Aoyama-Maeda, Taro Horino, Osamu Ichii, Yoshio Terada
Macrophage activation syndrome (MAS), a variant of secondary hemophagocytic lymphohistiocytosis, is a potentially life-threatening complication of inflammatory and autoimmune diseases. We present a case of MAS as a rare manifestation of systemic lupus erythematosus. Although initial treatment with corticosteroid, with or without cyclosporine A, is justified in patients with MAS, evidence regarding the effectiveness of this treatment protocol remains to be clarified. Our patient was successfully treated with a combination of intravenous immunoglobulin therapy and intravenous methyl predonisolone pulse therapy, which was followed by a course of oral prednisolone and oral tacrolimus...
November 1, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/29101772/liver-disease-symptoms-in-non-alcoholic-fatty-liver-disease-and-small-intestinal-bacterial-overgrowth
#5
Rahmatollah Rafiei, Mahboobeh Bemanian, Fereshteh Rafiei, Mahmood Bahrami, Lotfollah Fooladi, Giti Ebrahimi, Ahmadreza Hemmat, Zahra Torabi
INTRODUCTION: It seems that there is a relationship between small intestinal bacterial overgrowth (SIBO) and non-alcoholic fatty liver disease (NAFLD). The main objective of this study was to evaluate the prevalence of SIBO among NAFLD patients. METHODS: In this descriptive-analytical cross-sectional study, 98 eligible NAFLD patients were evaluated for SIBO using hydrogen breath test (HBT). They were divided into SIBO-positive and SIBO-negative groups. Demographic, clinical, and laboratory data were obtained...
October 26, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/29080394/trainee-involvement-increases-precut-rates-and-delays-access-to-the-common-bile-duct-without-an-increase-in-procedure-related-adverse-events-a-brave-new-world-of-ercp-training
#6
Theodor Voiosu, Andrei Voiosu, Andreea Benguş, Mihai Rimbaş, Bogdan Mateescu
BACKGROUND AND AIMS: Selective cannulation of the desired duct is a key element in ERCP procedures and an important step in the training of fellows. However, there is limited data about technical success and patient safety for ERCPs conducted in a training setting. We aimed to evaluate the impact of trainee involvement on the cannulation technique and procedure related outcomes at ERCP. MATERIALS AND METHODS: We conducted an observational study of all ERCP conducted in an endoscopy unit with an on-going training program...
October 26, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/29080393/lipid-profile-pattern-in-pediatric-overweight-population-with-or-without-nafld-in-relation-to-idf-criteria-for-metabolic-syndrome-a-preliminary-study
#7
Anca Bălănescu, Paul Bălănescu, Valentina Comanici, Iustina Stan, Beata Acs, Laura Prisăcariu, Florin Brezan, Tatiana Ciomârtan, Ioan Gherghina
BACKGROUND AND AIMS: The aim of this study is to assess the lipid profile pattern of pediatric overweight and/or obese patients with Non-Alcoholic Fatty Liver Disease (NAFLD) in relation to IDF Consensus Criteria for Metabolic Syndrome (MetS). MATERIAL AND METHODS: We conducted a cross-sectional preliminary study on 45 consecutive pediatric patients. Overweight or obese children aged from 3 to 18 years were included. Standardized measurement of blood pressure and anthropometric parameters were performed...
October 26, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/29028632/procalcitonin-as-a-diagnostic-and-prognostic-marker-in-diabetic-foot-infection-a-current-literature-review
#8
Dimitrios Velissaris, Nikolaos-Dimitrios Pantzaris, Christina Platanaki, Nikolina Antonopoulou, Charalampos Gogos
Diabetic foot ulcers (DFUs) are a very common cause of mortality and morbidity. The distinction between infected and non-infected DFU remains a very challenging task for clinicians in everyday practice. Even when infection is documented, the spectrum of diabetic foot infection is wide, ranging from cellulitis and soft tissue infection to osteomyelitis. Procalcitonin (PCT), a well-established sepsis biomarker, has been used in the diagnosis of several infections including osteomyelitis in patients with diabetes mellitus...
October 11, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28991776/serum-and-alveolar-procalcitonin-had-a-weak-diagnostic-value-for-ventilator-associated-pneumonia-in-patients-with-pulmonary-infection-score-%C3%A2-6
#9
Mehran Shokri, Roya Ghasemian, Masomeh Bayani, Valiollah Amri Maleh, Masoumeh Kamrani, Mahmoud Sadeghi-Haddad-Zavareh, Soheil Ebrahimpour
BACKGROUND: Measuring the serum and alveolar procalcitonin level as inflammatory marker in the diagnosis of ventilator-associated pneumonia (VAP) has been taken into account. In this study, serum and alveolar procalcitonin levels in patients with suspected VAP and patients with confirmed VAP were compared. METHODS: This cross-sectional study was conducted using 50 intubated intensive care unit (ICU) patients, connected to ventilator, from October 2014 to April 2015...
October 7, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28976911/association-of-cognitive-emotional-regulation-strategies-to-depressive-symptoms-in-type-2-diabetes-patients
#10
Andreia Ș Mocan, Silvia Ș Iancu, Adriana S Băban
AIM: The present cross-sectional observational study aimed to investigates the relation between cognitive - emotional regulation strategies and depressive symptoms in type 2 diabetes patients in the context of sociodemographic and clinical factors, of diabetes distress, perception of illness consequences and previous depression. METHOD: Multiple logistic regression was performed on the responses of 354 adults with type 2 diabetes (58.5% women; mean ± SD age: 61...
September 26, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28945608/association-of-neutrophil-to-lymphocyte-ratio-and-microalbuminuria-in-patients-with-normal-egfr
#11
Aysun Aybal Kutlugun, Fatma Ayerden Ebinc, Mujgan Tek Ozturk, Fatma Kaplan Efe, İbrahim Karadag, Murat Eser, Oktay Unsal, Serdar Karakaya
AIMS: The aim of this study was to evaluate the association between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and microalbuminuria in patients with normal estimated glomerular filtration rate (eGFR). METHODS: 174 patients who had eGFR≥60 ml/min/1.73 m2 were studied. Patients were divided into two groups according to the urinary albumin excretion as microalbuminuric group (n=105) and normoalbuminuric group (n=69). NLR and PLR levels were calculated...
September 23, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28918421/macrophage-activation-syndrome-at-the-onset-of-glucocorticoid-resistant-systemic-lupus-erythematosus-a-case-report
#12
Delia Tulbă, Marius Balea, Cristian Băicuș
INTRODUCTION: Macrophage activation syndrome (MAS) is a life-threatening hyperinflammatory state mediated by uncontrolled cytokine storm and haemophagocytosis. Although rarely reported, MAS might occur in systemic lupus erythematosus (SLE), notably as an inaugural manifestation. Glucocorticoids (GCs) are the cornerstone of SLE therapy. However, in some cases high doses of GCs are required to achieve remission (i.e. glucocorticoid-resistance), leading to significant side effects. CASE REPORT: A 28-year-old Romani male was admitted to our hospital for polyarthralgia, polyserositis and fatigability...
September 16, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28710883/an-atypical-type-i-gastric-neuroendocrine-tumor
#13
REVIEW
Andrada-Viorela Gheorghe, Mihai Rimbas, Octav Ginghina, Andrada Spanu, Theodor Alexandru Voiosu
BACKGROUND: Gastric neuroendocrine tumors (GI-NETs) are rare lesions, usually discovered incidentally during endoscopy. Based on their pathology, there are 4 types of GI-NETs. Type I are multiple small polypoid lesions with central ulceration located in the gastric body or the fundus, associated with atrophic gastritis usually noninvasive and very rarely metastatic. We report on a rare case of a gastric NET arising from the muscularis propria layer of the pyloric ring. CASE REPORT: We present the case of a 65-year old woman with a history of alcoholic cirrhosis, investigated for melena...
December 1, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28704202/the-integration-of-the-molecular-methods-in-the-diagnosis-algorithm-for-the-poliovirus-detection-in-the-sewage-water-comparing-concentration-and-detection-methods-a-pilot-study
#14
REVIEW
Anda Băicuş
INTRODUCTION: Two cases of circulating vaccine-derived poliovirus type 1(cVDPV1), from southwestern Ukraine, bordering Romania, were confirmed in 2015 and the environmental enterovirus surveillance was enhanced in our country. The molecular detection of human enteroviruses as a screening test followed by isolation on cell culture lines or sequencing could be proposed as a new diagnosis algorithm. MATERIAL AND METHODS: The sensitivity of two molecular methods for the detection of enterovirus strains in 10 mL of sewage water (15 samples) was studied with Film Array ME panel BioFire (Biomerieux, France) and Xpert EV assay (Cepheid, USA)...
December 1, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28704201/il-17-and-th17-cells-in-systemic-sclerosis-a-comprehensive-review
#15
REVIEW
Paul Bălănescu, Eugenia Bălănescu, Anca Bălănescu
T cells (especially T helper cells) seem to be strongly associated with systemic sclerosis pathogenesis. Th17-IL-17 axis was proved to be involved in the pathogenesis of multiple autoimmune diseases. By performing a comprehensive research of the literature indexed in PubMed database, the current review summarizes current knowledge related to Th17 and IL-17 in systemic sclerosis. While there is promising data suggesting inhibition of Tregulatory and Th1 signals on one hand and promotion of Th17 and Th2 signals on the other, studies that include prospective and integrated analysis of Tregulatory, Th17, Th1, Th2 (cells and derived cytokines) on the same cohort of Ssc patients are warranted...
December 1, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28672766/the-value-of-peripheral-blood-eosinophil-count-in-predicting-in-stent-restenosis-in-patients-with-stable-angina-pectoris-undergoing-drug-eluting-stenting
#16
Reza Hajizadeh, Samad Ghaffari, Ahmad Separham, Behrouz Shokouhi, Hadiseh Kavandi, Leili Pourafkari, Nader D Nader
INTRODUCTION: In-stent restenosis (ISR) remains a major limitation of percutaneous coronary intervention (PCI). A role for peripheral blood cells as major regulators of immune and inflammatory systems has been proposed. We aim to evaluate the relationship between eosinophil count and development of restenosis after drug-eluting stent (DES) implantation. METHODS: In this prospective study, all consecutive patients undergoing elective DES implantation for chronic stable angina (CSA) in a university-affiliated heart center within a 6-month period were enrolled and followed for another 6 months...
December 1, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28672763/a-step-by-step-approach-in-differential-diagnosing-of-adrenal-incidentaloma-epinephroma-with-comments-on-the-new-clinical-practice-guidelines-of-the-european-society-of-endocrinology
#17
REVIEW
Frederick-Anthony Farrugia, Evangelos Misiakos, Georgios Martikos, Panagiotis Tzanetis, Anestis Charalampopoulos, Nicolaos Zavras, Dimitrios Sotiropoulos, Nikolaos Koliakos
OBJECTIVES: To present a step by step approach for the diagnosis of adrenal incidentaloma (AI). METHOD: An extensive review of the literature was conducted, searching the Pub-Med and Google Scholar using the Mesh terms; Adrenal; Incidentaloma; Adrenal tumours; Radiology; Diagnosis. We also did a cross-referencing search of the literature. Comments on the new European guidelines are presented. RESULTS: The majority of the tumours are non-functioning benign adenomas...
December 1, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28667815/pulmonary-thromboembolism-in-an-emergency-hospital-are-our-patients-different
#18
REVIEW
Ana Maria Balahura, Andrada Guţă, Vlad Mihalcea, Emma Weiss, Maria Dorobanţu, Daniela Bartoş, Elisabeta Bădilă, Gheorghe Andrei Dan
INTRODUCTION: Pulmonary thromboembolism (PTE) represents a medical emergency and is the third most common cause of mortality after myocardial infarction and stroke. The purpose of this study was to describe the characteristics and management of patients with PTE admitted in a referral emergency hospital in Romania. MATERIAL AND METHODS: We retrospectively reviewed all cases of PTE diagnosed in one of the largest emergency hospitals in Bucharest during a 2-year period (January 2014 - December 2016)...
December 1, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28640754/raised-tsh-is-associated-with-endothelial-dysfunction-in-metabolic-syndrome-a-case-control-study
#19
Ashok Kumar Ahirwar, Archana Singh, Anju Jain, Surajeet Kumar Patra, Binita Goswami, M K Bhatnagar, Jayashree Bhattacharjee
INTRODUCTION: Endothelial dysfunction has been considered as one of the important factors in pathogenesis of Metabolic Syndrome (Met S). Subclinical hypothyroidism (SCH) has also been reported to be associated with Met S. The aim of our study is to evaluate the association of raised TSH with mediators of endothelial dysfunction in Met S with Subclinical hypothyroidism as compared to healthy controls. METHODS: Study population consisted of 100 subjects, out of which 50 were cases of Met S and 50 were healthy controls...
December 1, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28599401/the-frequency-of-bone-fractures-among-patients-with-chronic-kidney-disease-not-on-dialysis-two-year-follow-up
#20
Andreja Figurek, Vlastimir Vlatkovic, Dragan Vojvodic, Branislav Gasic, Milorad Grujicic
INTRODUCTION: Renal osteodystrophy is a severe complication of chronic kidney disease (CKD) that increases morbidity and mortality in these patients. Mineral and bone disorder starts early in CKD and affects the incidence of bone fractures. The aim of this study was to observe the frequency of diverse bone fractures in patients with CKD not on dialysis. METHODS: This cohort study included 68 patients that were followed during the two-year period. The patients were divided into two cohorts: one that developed bone fractures and the other that did not...
December 1, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
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