journal
MENU ▼
Read by QxMD icon Read
search

Nuclear Medicine and Biology

journal
https://www.readbyqxmd.com/read/28917111/-11-c-pf-3274167-as-a-pet-radiotracer-of-oxytocin-receptors-radiosynthesis-and-evaluation-in-rat-brain
#1
Benjamin Vidal, Iuliia A Karpenko, François Liger, Sylvain Fieux, Caroline Bouillot, Thierry Billard, Marcel Hibert, Luc Zimmer
INTRODUCTION: Oxytocin plays a major role in the regulation of social interactions in mammals by interacting with the oxytocin receptor (OTR) expressed in the brain. Furthermore, the oxytocin system appears as a possible therapeutic target in autism spectrum disorders and other psychiatric troubles, justifying current pharmacological researches. Since no specific PET radioligand is currently available to image OTR in the brain, the aim of this study was to radiolabel the specific OTR antagonist PF-3274167 and to evaluate [(11)C]PF-3274167 as a potential PET tracer for OTR in rat brains...
August 2, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28803001/continuation-of-comprehensive-quality-control-of-the-itg-68-ge-68-ga-generator-and-production-of-68-ga-dotatoc-and-68-ga-psma-hbed-cc-for-clinical-research-studies
#2
Alejandro Amor-Coarasa, James M Kelly, Monika Gruca, Anastasia Nikolopoulou, Shankar Vallabhajosula, John W Babich
Performance of a second itG (68)Ge/(68)Ga generator system and production of (68)Ga-DOTATOC and (68)Ga-PSMA-HBED-CC were tested over one year as an accompaniment to a previously published study (J Nucl Med. 2016;57:1402-1405). METHODS: Performance of a 1951MBq (68)Ge/(68)Ga generator was characterized and the eluate used for preparation of (68)Ga-DOTATOC and (68)Ga-PSMA-HBED-CC. Weekly elution profiles of (68)Ga elution yield and (68)Ge breakthrough were determined. RESULTS: (68)Ga elution yields averaged 82% (61...
July 14, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28863330/-18-f-labeled-perfluorocarbon-droplets-for-positron-emission-tomography-imaging
#3
Nagina Amir, David Green, Jeff Kent, Yun Xiang, Ivan Gorelikov, Minseok Seo, Megan Blacker, Nancy Janzen, Shannon Czorny, John F Valliant, Naomi Matsuura
INTRODUCTION: Nanoscale perfluorocarbon (PFC) droplets have been used to create imaging agents and drug delivery vehicles. However, development and characterization of new formulations of PFC droplets are hindered because of the lack of simple methods for quantitative and sensitive assessment of whole body tissue distribution and pharmacokinetics of the droplets. To address this issue, a general-purpose method for radiolabeling the inner core of nanoscale perfluorocarbon droplets with a hydrophobic and lipophobic fluorine-18 compound was developed, so that positron emission tomography (PET) and quantitative biodistribution studies can be employed to evaluate PFC nanodroplets in vivo...
July 12, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28821003/-111-in-dtpa-d-phe-1-asp-0-d-phe-1-octreotide-exhibits-higher-tumor-accumulation-and-lower-renal-radioactivity-than-111-in-dtpa-d-phe-1-octreotide
#4
Nobuhiro Oshima, Hiromichi Akizawa, Hirotake Kitaura, Hidekazu Kawashima, Songji Zhao, Yan Zhao, Ken-Ichi Nishijima, Yoji Kitamura, Yasushi Arano, Yuji Kuge, Kazue Ohkura
INTRODUCTION: (111)In-DTPA-d-Phe(1)-octreotide scintigraphy is an important method of detecting neuroendocrine tumors. We previously reported that a new derivative of (111)In-DTPA-d-Phe(1)-octreotide, (111)In-DTPA-d-Phe(-1)-Asp(0)-d-Phe(1)-octreotide, accomplished the reduction of prolonged renal accumulation of radioactivity. The aim of this study was to evaluate the tumor accumulation of (111)In-DTPA-d-Phe(-1)-Asp(0)-d-Phe(1)-octreotide in vitro and in vivo by comparing it with (111)In-DTPA-d-Phe(1)-octreotide...
July 12, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28810154/synthesis-and-evaluation-of-a-99m-tc-labeled-chemokine-receptor-antagonist-peptide-for-imaging-of-chemokine-receptor-expressing-tumors
#5
Azadeh Mikaeili, Mostafa Erfani, Omid Sabzevari
OBJECTIVE: The chemokine receptor CXCR4 is highly expressed in tumor cells and plays an important role in tumor metastasis. In the present study, we report on the evaluation of a new radiopharmaceutical peptide for its potential to visualization for CXCR4-expressing tumors in vivo. METHODS: A CXCR4 antagonist analogue was synthesized using a standard Fmoc solid phase strategy and labeled with (99m)Tc via HYNIC and EDDA/tricine as coligands. In addition, stability in human serum, receptor binding internalization, in vivo tumor uptake, and tissue biodistribution were evaluated...
July 12, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28810153/evaluation-of-affibody-molecule-based-pna-mediated-radionuclide-pretargeting-development-of-an-optimized-conjugation-protocol-and-177-lu-labeling
#6
Mohamed Altai, Kristina Westerlund, Justin Velletta, Bogdan Mitran, Hadis Honarvar, Amelie Eriksson Karlström
INTRODUCTION: We have previously developed a pretargeting approach for affibody-mediated cancer therapy based on PNA-PNA hybridization. In this article we have further developed this approach by optimizing the production of the primary agent, ZHER2:342-SR-HP1, and labeling the secondary agent, HP2, with the therapeutic radionuclide (177)Lu. We also studied the biodistribution profile of (177)Lu-HP2 in mice, and evaluated pretargeting with (177)Lu-HP2 in vitro and in vivo. METHODS: The biodistribution profile of (177)Lu-HP2 was evaluated in NMRI mice and compared to the previously studied (111)In-HP2...
July 12, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28793277/o-2-18-f-fluoroethyl-l-tyrosine-18-f-fet-uptake-in-insulinoma-first-results-from-a-xenograft-mouse-model-and-from-human
#7
Alessio Imperiale, Frédéric Boisson, Guillaume Kreutter, Bernard Goichot, Izzie Jacques Namer, Philippe Bachellier, Patrice Laquerriere, Laurence Kessler, Patrice Marchand, David Brasse
INTRODUCTION: Herein we have evaluated the uptake of O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) in insulinoma in comparison with those of 6-(18)F-fluoro-3,4-dihydroxy-l-phenylalanine ((18)F-FDOPA) providing first data from both murine xenograft model and one patient with proved endogenous hyperinsulinemic hypoglycemia. METHODS: Dynamic (18)F-FET and carbidopa-assisted (18)F-FDOPA PET were performed on tumor-bearing nude mice after subcutaneous injection of RIN-m5F murine beta cells and on a 30-year-old man with type-1 multiple endocrine neoplasia and hyperinsulinemic hypoglycemia defined by a positive fasting test...
July 12, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28797928/comparison-of-planar-pet-and-well-counter-measurements-of-total-tumor-radioactivity-in-a-mouse-xenograft-model
#8
Michael V Green, Jurgen Seidel, Mark R Williams, Karen J Wong, Anita Ton, Falguni Basuli, Peter L Choyke, Elaine M Jagoda
INTRODUCTION: Quantitative small animal radionuclide imaging studies are often carried out with the intention of estimating the total radioactivity content of various tissues such as the radioactivity content of mouse xenograft tumors exposed to putative diagnostic or therapeutic agents. We show that for at least one specific application, positron projection imaging (PPI) and PET yield comparable estimates of absolute total tumor activity and that both of these estimates are highly correlated with direct well-counting of these same tumors...
June 30, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28648984/whole-body-biodistribution-of-the-cannabinoid-type-1-receptor-ligand-18-f-mk-9470-in-the-rat
#9
H G Buchholz, K Uebbing, S Maus, S Pektor, N Afahaene, V Weyer-Elberich, B Lutz, M Schreckenberger, I Miederer
The endocannabinoid system participates in many processes in the body, including memory, reward, pain, motor activity, food intake, energy metabolism, and gastrointestinal functions. [(18)F]MK-9470 is a positron emission tomography (PET) ligand that binds with high affinity and selectivity to the cannabinoid type 1 receptor. In order to fully characterize ligand behavior, tracer uptake measured using in vivo microPET was compared with results from ex vivo tissue dissection. Twelve male Sprague-Dawley rats were divided into three subgroups and scanned over time periods of 10min, 30min and 90min using PET...
September 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28636973/amide-to-triazole-switch-vs-in-vivo-nep-inhibition-approaches-to-promote-radiopeptide-targeting-of-grpr-positive-tumors
#10
Theodosia Maina, Aikaterini Kaloudi, Ibai E Valverde, Thomas L Mindt, Berthold A Nock
INTRODUCTION: Radiolabeled bombesin (BBN)-analogs have been proposed for diagnosis and therapy of gastrin-releasing peptide receptor (GRPR)-expressing tumors, such as prostate, breast and lung cancer. Metabolic stability represents a crucial factor for the success of this approach by ensuring sufficient delivery of circulating radioligand to tumor sites. The amide-to-triazole switch on the backbone of DOTA-PEG4-[Nle(14)]BBN(7-14) (1) was reported to improve the in vitro stability of resulting (177)Lu-radioligands...
September 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28628775/developing-new-pet-tracers-to-image-the-growth-hormone-secretagogue-receptor-1a-ghs-r1a
#11
Kazunori Kawamura, Masayuki Fujinaga, Yoko Shimoda, Tomoteru Yamasaki, Yiding Zhang, Akiko Hatori, Lin Xie, Hidekatsu Wakizaka, Katsushi Kumata, Takayuki Ohkubo, Yusuke Kurihara, Masanao Ogawa, Nobuki Nengaki, Ming-Rong Zhang
INTRODUCTION: `The growth hormone secretagogue receptor 1a (GHS-R1a) is the orphan G-protein-coupled receptor, and its endogenous ligand is ghrelin. GHS-R1a contributes to regulation of glucose homeostasis, memory and learning, food addiction, and neuroprotection. Several PET tracers for GHS-R1a have been developed, but none have been reported to be clinically applicable to GHS-R1a imaging. In this study, we developed three new PET tracers for GHS-R1a: (18)F-labeled 6-(4-chlorophenyl)-3-((1-(2-fluoroethyl)piperidin-3-yl)methyl)-2-(o-tolyl)quinazolin-4(3H)-one (1), (11)C-labeled 6-(4-chlorophenyl)-3-((1-(2-methoxyethyl)piperidin-3-yl)methyl)-2-(o-tolyl)quinazolin-4(3H)-one (2), and (11)C-labeled (S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(4'-methoxy-[1,1'-biphenyl]-4-yl)methanone (3)...
September 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28624669/neutron-activatable-radionuclide-cancer-therapy-using-graphene-oxide-nanoplatelets
#12
Junghyun Kim, Michael Jay
Neutron-activation is a promising method of generating radiotherapeutics with minimal handling of radioactive materials. Graphene oxide nanoplatelets (GONs) were examined as a carrier for neutron-activatable holmium with the purpose of exploiting inherent characteristics for theranostic application. GONs were hypothesized to be an ideal candidate for this application owing to their desirable characteristics such as a rigid structure, high metal loading capacity, low density, heat resistance, and the ability to withstand harsh environments associated with the neutron-activation process...
September 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28602965/-67-ga-labeled-deferoxamine-derivatives-for-imaging-bacterial-infection-preparation-and-screening-of-functionalized-siderophore-complexes
#13
Joseph A Ioppolo, Deanna Caldwell, Omid Beiraghi, Lisset Llano, Megan Blacker, John F Valliant, Paul J Berti
INTRODUCTION: Deferoxamine (DFO) is a siderophore that bacteria use to scavenge iron and could serve as a targeting vector to image bacterial infection where current techniques have critical limitations. [(67)Ga]-DFO, which is a mimetic of the corresponding iron complex, is taken up by bacteria in culture, however in vivo it clears too rapidly to allow for imaging of infection. In response, we developed several new DFO derivatives to identify those that accumulate in bacteria, and at sites of infection, and that could potentially have improved pharmacokinetics...
September 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28599133/dose-on-demand-production-of-diverse-18-f-radiotracers-for-preclinical-applications-using-a-continuous-flow-microfluidic-system
#14
Lidia Matesic, Annukka Kallinen, Ivan Greguric, Giancarlo Pascali
INTRODUCTION: The production of (18)F-radiotracers using continuous flow microfluidics is under-utilized due to perceived equipment limitations. We describe the dose-on-demand principle, whereby the back-to-back production of multiple, diverse (18)F-radiotracers can be prepared on the same day, on the same microfluidic system using the same batch of [(18)F]fluoride, the same microreactor, the same HPLC column and SPE cartridge to obtain a useful production yield. METHODS: [(18)F]MEL050, [(18)F]Fallypride and [(18)F]PBR111 were radiolabeled with [(18)F]fluoride using the Advion NanoTek Microfluidic Synthesis System...
September 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28578290/-131-i-labeled-chitosan-hydrogels-for-radioembolization-a-preclinical-study-in-small-animals
#15
Hyosook Hwang, Kwang Il Kim, JeongIl Kwon, Byoung Soo Kim, Hwan-Seok Jeong, Su Jin Jang, Phil-Sun Oh, Ho Sung Park, Seok Tae Lim, Myung-Hee Sohn, Hwan-Jeong Jeong
INTRODUCTION: The purpose of the study was to examine potential of (131)I-labeled chitosan hydrogels (Chi) for treatment of liver cancer. METHODS: Orthotopic hepatoma was induced by McA-RH7777-fLuc cells (1×10(7)) that were injected into the left hepatic lobe of rats. Ten days later, tumor-bearing rats evidenced by bioluminescence received (125)I-labeled Chi with left hepatic artery access. Pharmacokinetics and excretion (n=8) and biodistribution (n=6/time point) were studied after injection...
September 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28575795/-11-c-erlotinib-pet-cannot-detect-acquired-erlotinib-resistance-in-nsclc-tumor-xenografts-in-mice
#16
Alexander Traxl, Taraneh Beikbaghban, Thomas Wanek, Kushtrim Kryeziu, Christine Pirker, Severin Mairinger, Johann Stanek, Thomas Filip, Michael Sauberer, Claudia Kuntner, Walter Berger, Oliver Langer
INTRODUCTION: [(11)C]Erlotinib PET has shown promise to distinguish non-small cell lung cancer (NSCLC) tumors harboring the activating epidermal growth factor receptor (EGFR) mutation delE746-A750 from tumors with wild-type EGFR. To assess the suitability of [(11)C]erlotinib PET to detect the emergence of acquired erlotinib resistance in initially erlotinib-responsive tumors, we performed in vitro binding and PET experiments in mice bearing tumor xenografts using a range of different cancer cells, which were erlotinib-sensitive or exhibited clinically relevant resistance mechanisms to erlotinib...
September 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28575794/-99m-tc-labeled-psma-inhibitor-biokinetics-and-radiation-dosimetry-in-healthy-subjects-and-imaging-of-prostate-cancer-tumors-in-patients
#17
Clara Santos-Cuevas, Jenny Davanzo, Guillermina Ferro-Flores, Francisco O García-Pérez, Blanca Ocampo-García, Eleazar Ignacio-Alvarez, Edgar Gómez-Argumosa, Martha Pedraza-López
The prostate-specific membrane antigen (PSMA) is expressed in epithelial cells of the prostate and highly overexpressed in 95% of advanced prostate cancers. The aims of this study was to estimate the biokinetics and dosimetry of (99m)Tc-EDDA/HYNIC-iPSMA ((99m)Tc-labeled PSMA inhibitor) in eight healthy subjects and evaluate its usefulness as a tumor-imaging agent in eight prostate cancer patients. METHODS: (99m)Tc-EDDA/HYNIC-iPSMA was obtained from a lyophilized formulation with radiochemical purities >98%, determined by reversed-phase HPLC and ITLC-SG analyses...
September 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28577428/vpac1-targeted-64-cu-tp3805-kit-preparation-and-its-evaluation
#18
Sushil K Tripathi, Pardeep Kumar, Edouard J Trabulsi, Sung Kim, Peter A McCue, Charles Intenzo, Adam Berger, Leonard Gomella, Mathew L Thakur
INTRODUCTION: Previously, our laboratory has shown that (64)Cu-TP3805 can specifically target VPAC1 receptors and be used for positron emission tomography (PET) imaging of breast (BC) and prostate cancer (PC) in humans. Present work is aimed at the formulation of a freeze-dried diaminedithiol-peptide (N2S2-TP3805) kit and it's evaluation for the preparation of (64)Cu labeled TP3805. Parameters such as pH, temperature and incubation time were examined that influenced the radiolabeling efficiency and stability of the product...
August 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28575697/pet-ct-with-18-f-choline-physiological-whole-bio-distribution-in-male-and-female-subjects-and-diagnostic-pitfalls-on-1000-prostate-cancer-patients-18-f-choline-pet-ct-bio-distribution-and-pitfalls-a-southern-italian-experience
#19
Ferdinando Calabria, Agostino Chiaravalloti, Carmelo Cicciò, Vincenzo Gangemi, Domenico Gullà, Federico Rocca, Gianpasquale Gallo, Giuseppe Lucio Cascini, Orazio Schillaci
INTRODUCTION: The (11)C/(18)F-choline is a PET/CT radiopharmaceutical useful in detecting tumors with high lipogenesis. (11)C/(18)F-choline uptake can occur in physiological conditions or tumors. The knowledge of its bio-distribution is essential to recognize physiologic variants or diagnostic pitfalls. Moreover, few information are available on the bio-distribution of this tracer in female patients. Our aim was to discuss some documented (18)F-choline PET/CT pitfalls in prostate cancer patients...
August 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28456080/radiosynthesis-and-biological-evaluation-of-n-2-18-f-fluoropropionyl-3-4-dihydroxy-l-phenylalanine-as-a-pet-tracer-for-oncologic-imaging
#20
Caihua Tang, Dahong Nie, Ganghua Tang, Siyuan Gao, Shaoyu Liu, Fuhua Wen, Xiaolan Tang
INTRODUCTION: Several (11)C and (18)F labeled 3,4-dihydroxy-l-phenylalanine (l-DOPA) analogues have been used for neurologic and oncologic diseases, especially for brain tumors and neuroendocrine tumors PET imaging. However, (18)F-labeled N-substituted l-DOPA analogues have not been reported so far. In the current study, radiosynthesis and biological evaluation of a new (18)F-labeled l-DOPA analogue, N-(2-[(18)F]fluoropropionyl)-3,4-dihydroxy-l-phenylalanine ([(18)F]FPDOPA) for tumor PET imaging are performed...
July 2017: Nuclear Medicine and Biology
journal
journal
31285
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"