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Nuclear Medicine and Biology

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https://www.readbyqxmd.com/read/29225073/corrigendum-to-131i-labeled-chitosan-hydrogels-for-radioembolization-a-preclinical-study-in-small-animals-nucl-med-biol-52-2017-16-23
#1
Hyosook Hwang, Kwang Il Kim, JeongIl Kwon, Byoung Soo Kim, Hwan-Seok Jeong, Su Jin Jang, Phil-Sun Oh, Ho Sung Park, Seok Tae Lim, Myung-Hee Sohn, Hwan-Jeong Jeong
No abstract text is available yet for this article.
December 7, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29309920/an-electrochemical-approach-for-removal-of-radionuclidic-contaminants-of-eu-from-153sm-for-effective-use-in-metastatic-bone-pain-palliation
#2
Rubel Chakravarty, Sudipta Chakraborty, Mohammed Sahiralam Khan, Ramu Ram, Haladhar Dev Sarma, Ashutosh Dash
INTRODUCTION: Thermal neutron activation of 152Sm [152Sm(n,γ)153Sm] using natural or isotopically enriched (by 152Sm) samarium target is the established route for production of 153Sm used for preparation of 153Sm-EDTMP for pain palliation in cancer patients with disseminated bone metastases. However, some long-lived radionuclidic contaminants of Eu, such as, 154Eu (t½=8.6y) are also produced during the target activation process. This leads to detectable amount of Eu radionuclidic contaminants in patients' skeleton even years after administration with therapeutic doses of 153Sm-EDTMP...
December 6, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29306111/deuterated-18f-9-o-hexadeutero-3-fluoropropoxyl-dihydrotetrabenazine-d6-fp-dtbz-a-vesicular-monoamine-transporter-2-vmat2-imaging-agent
#3
Futao Liu, Seok Rye Choi, Zhihao Zha, Karl Ploessl, Lin Zhu, Hank F Kung
INTRODUCTION: Vesicular monoamine transporters 2 (VMAT2) in the brain serve as transporter for packaging monoamine in vesicles for normal CNS neurotransmission. Several VMAT2 imaging agents, [11C]-(+)-DTBZ, dihydrotetrabenazine and [18F]FP-(+)-DTBZ (9-O-fluoropropyl-(+)-dihydro tetrabenazine, a.k.a. [18F]AV-133), are useful for studying the changes in brain function related to monoamine transmission by in vivo imaging. Deuterated analogs have been reported targeting VMAT2 binding sites...
December 6, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29309919/expanding-logp-present-possibilities
#4
Chrysoula Vraka, Sanja Mijailovic, Vanessa Fröhlich, Markus Zeilinger, Eva-Maria Klebermass, Wolfgang Wadsak, Karl-Heinz Wagner, Marcus Hacker, Markus Mitterhauser
INTRODUCTION: Due to the high candidate exclusion rate during a drug development process, an early prediction of the pharmacokinetic behavior would be needed. Accordingly, high performance bioaffinity chromatography (HPBAC) approaches are growing in popularity, however, there is a lack of knowledge and no consensus about the relation between HPBAC measurements, in vivo distribution and blood brain barrier (BBB) penetration behavior. With respect to radiotracers, there is almost no reference data available for plasma protein binding (PPB), permeability (Pm) and the membrane coefficient (KIAM)...
November 28, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29227813/speed-matters-to-raise-molar-radioactivity-fast-hplc-shortens-the-quality-control-of-c-11-pet-tracers
#5
Lukas Nics, Britta Steiner, Eva-Maria Klebermass, Cecile Philippe, Markus Mitterhauser, Marcus Hacker, Wolfgang Wadsak
INTRODUCTION: The decision whether an in-house produced short-lived radiopharmaceutical can be applied in-vivo is based on (1) the fulfilment of all quality criteria; (2) the availability of enough radioactivity for subsequent imaging; and (3) a molar activity (MA) above the set limits to guarantee safe administration without competing occupancy of the non-radioactive compound; and (4) an activity concentration, which is high enough for the application in certain preclinical studies. Hence, time reduction can be of major importance to increase final product yields, MA and activity concentrations...
November 21, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29175467/synthesis-in-vitro-and-in-vivo-evaluation-of-18f-fluoronorimatinib-as-radiotracer-for-imatinib-sensitive-gastrointestinal-stromal-tumors
#6
Martin Prause, Sabrina Niedermoser, Carmen Wängler, Clemens Decristoforo, Uwe Seibold, Stephanie Riester, Takahiro Taguchi, Ralf Schirrmacher, Gert Fricker, Björn Wängler
INTRODUCTION: Gastrointestinal stromal tumors (GIST) have a wide range of mutations, but can mostly be treated with Imatinib, until eventually resistance towards this tyrosine kinase inhibitor is acquired. Early and non-invasive determination of the sensitivity of the tumor and its metastases towards Imatinib by positron emission tomography (PET) would be beneficial for therapy planning and monitoring. METHODS: We developed a synthesis strategy towards the precursor molecule, performed the 18F-synthesis and in the following evaluated the radioligand in vitro regarding its lipophilicity, stability and biological activity (KIT binding properties) as well as its in vivo properties in GIST tumor-bearing mice...
November 17, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29291493/89zr-for-antibody-labeling-and-in-vivo-studies-a-comparison-between-liquid-and-solid-target-production
#7
Gemma M Dias, Caterina F Ramogida, Julie Rousseau, Nicholas A Zacchia, Cornelia Hoehr, Paul Schaffer, Kuo-Shyan Lin, François Bénard
INTRODUCTION: Zirconium-89 (89Zr, t1/2=78.4h) liquid target (LT) production offers an approach to introduce this positron-emitting isotope to cyclotron centres without the need for a separate solid target (ST) production set up. We compared the production, purification, and antibody radiolabeling yields of 89Zr-(LT) and 89Zr-(ST), and assessed the feasibility of 89Zr-(LT) for preclinical PET/CT. METHODS: 89Zr-(ST) production was performed with an 89Y foil on a TR 19 cyclotron at 13...
November 16, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29227814/synthesis-and-evaluation-of-99mtc-re-tricarbonyl-complexes-of-the-triphenylphosphonium-cation-for-mitochondrial-targeting
#8
Georgios Paparidis, Melpomeni Akrivou, Vicky Tsachouridou, Antonio Shegani, Ioannis S Vizirianakis, Ioannis Pirmettis, Minas S Papadopoulos, Dionysia Papagiannopoulou
INTRODUCTION: Lipophilic delocalized cations accumulate in tumor cell mitochondria due to their higher transmembrane potential. In this work, this strategy was adopted for the development of 99mTc tumor-targeted imaging agents. METHODS: Two tridentate ligands containing the triphenylphosphonium cation, L1 (S-cysteinyl) and L2 (N-iminodiacetate) as well as the respective 99mTc/ReL1 and 99mTc/ReL2 tricarbonyl complexes were synthesized. The effect of the ligands and the Re complexes on cell growth in U-87 MG glioblastoma cells was assessed...
November 13, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29331921/cyclotron-production-of-99mtc-comparison-of-known-separation-technologies-for-isolation-of-99mtc-from-molybdenum-targets
#9
REVIEW
Magdalena Gumiela
Intensive efforts were undertaken during the last few decades for the separation of cyclotron-produced 99mTc from 99Mo and new papers have been published on this topic since the last review [1]. In the future the cyclotron-based methods can replace reactor-based technology in producing this medical radioisotope and the nuclear reaction 100Mo(p,2n)99mTc appears to be the most worthwhile approach. New ways of producing of 99mTc require efficient separation methods. Several strategies for separation of 99mTc from 99Mo have been already developed...
November 10, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29223716/alkaline-degradation-of-lyophilized-dmsa-prior-to-labeling-with-99mtc-identification-and-development-of-the-degradation-pathway-by-hplc-and-ms
#10
Erika V Almeida, Samuel L De Brito
INTRODUCTION: Complexes of technetium-99m (99mTc) with meso-dimercaptosuccinic acid (DMSA) have been widely used as diagnostic agents in nuclear medicine. The degradation products (DP) of DMSA formed under different forced conditions have been identified through HPLC-DAD and LC-MSn studies. In this study, the DMSA kit was subjected to forced degradation under hydrolysis conditions as prescribed by the International Conference on Harmonization (ICH) guideline Q1A. METHODS: Chromatographic separation was accomplished on a reverse phase Shim-Pack VP-ODS (150 mm × 4...
November 10, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29172120/-18-f-labeled-norepinephrine-transporter-tracer-18-f-ns12137-radiosynthesis-and-preclinical-evaluation
#11
Anna K Kirjavainen, Sarita Forsback, Francisco R López-Picón, Päivi Marjamäki, Jatta Takkinen, Merja Haaparanta-Solin, Dan Peters, Olof Solin
INTRODUCTION: Several psychiatric and neurodegenerative diseases are associated with malfunction of brain norepinephrine transporter (NET). However, current clinical evaluations of NET function are limited by the lack of sufficiently sensitive methods of detection. To this end, we have synthesized exo-3-[(6-[(18)F]fluoro-2-pyridyl)oxy]-8-azabicyclo[3.2.1]-octane ([(18)F]NS12137) as a radiotracer for positron emission tomography (PET) and have demonstrated that it is highly specific for in vivo detection of NET-rich regions of rat brain tissue...
October 24, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29223715/development-of-two-fluorine-18-labeled-pet-radioligands-targeting-pde10a-and-in-vivo-pet-evaluation-in-nonhuman-primates
#12
Vladimir Stepanov, Akihiro Takano, Ryuji Nakao, Nahid Amini, Shotaro Miura, Tomoaki Hasui, Haruhide Kimura, Takahiko Taniguchi, Christer Halldin
INTRODUCTION: Phosphodiesterase 10A (PDE10A) is a member of the PDE enzyme family that degrades cyclic adenosine and guanosine monophosphates (cAMP and cGMP). Based on the successful development of [11C]T-773 as PDE10A positron emission tomography (PET) radioligand, in this study our aim was to develop and evaluate fluorine-18 analogs of [11C]T-773. METHODS: [18F]FM-T-773-d2 and [18F]FE-T-773-d4 were synthesized from the same precursor used for 11C-labeling of T-773 in a two-step approach via 18F-fluoromethylation and 18F-fluoroethylation, respectively, using corresponding deuterated synthons...
October 23, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29154145/evaluation-of-a-novel-grpr-antagonist-for-prostate-cancer-pet-imaging-64-cu-dotha2-peg-rm26
#13
Nematallah Mansour, Michel Paquette, Samia Ait-Mohand, Véronique Dumulon-Perreault, Brigitte Guérin
INTRODUCTION: Gastrin releasing peptide receptors (GRPRs) are significantly over-expressed on a large proportion of prostate cancers making them prime candidates for receptor-mediated nuclear imaging by PET. Recently, we synthesized a novel bifunctional chelator (BFC) bearing hydroxamic acid arms (DOTHA2). Here we investigated the potential of a novel DOTHA2-conjugated, (64)Cu-radiolabeled GRPR peptide antagonist, [D-Phe(6)-Sta(13)-Leu(14)-NH2]bombesin(6-14) (DOTHA2-PEG-RM26) to visualize prostate tumors by PET imaging...
October 23, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29117904/the-past-present-and-the-promise-of-the-future-of-nuclear-medicine-and-biology
#14
EDITORIAL
W C Eckelman, A D Windhorst, C O'Hara
No abstract text is available yet for this article.
December 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29100560/reconsider-logp
#15
LETTER
Chrysoula Vraka, Markus Mitterhauser
No abstract text is available yet for this article.
November 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29100559/is-logp-truly-dead
#16
LETTER
Michael R Kilbourn, Peter J H Scott
No abstract text is available yet for this article.
November 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29055836/assessment-of-psma-targeting-ligands-bearing-novel-chelates-with-application-to-theranostics-stability-and-complexation-kinetics-of-68-ga-3-111-in-3-177-lu-3-and-225-ac-3
#17
James M Kelly, Alejandro Amor-Coarasa, Anastasia Nikolopoulou, Dohyun Kim, Clarence Williams, Shankar Vallabhajosula, John W Babich
INTRODUCTION: Recent successes in the treatment of metastatic castration-resistant prostate cancer (mCRPCa) by systemic endoradiotherapy has sparked renewed interest in developing small molecule ligands targeting prostate-specific membrane antigen (PSMA) and chelators capable of stable complexation of metal radionuclides for imaging and therapy. As the size and coordination number of metals for imaging, such as (68)Ga(3+), and for targeted therapy, such as (177)Lu(3+) and (225)Ac(3+), are substantially different, they may show a preference for macrocycles of different denticity...
October 3, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29074076/consensus-nomenclature-rules-for-radiopharmaceutical-chemistry-setting-the-record-straight
#18
REVIEW
Heinz H Coenen, Antony D Gee, Michael Adam, Gunnar Antoni, Cathy S Cutler, Yasuhisa Fujibayashi, Jae Min Jeong, Robert H Mach, Thomas L Mindt, Victor W Pike, Albert D Windhorst
Over recent years, within the community of radiopharmaceutical sciences, there has been an increased incidence of incorrect usage of established scientific terms and conventions, and even the emergence of 'self-invented' terms. In order to address these concerns, an international Working Group on 'Nomenclature in Radiopharmaceutical Chemistry and related areas' was established in 2015 to achieve clarification of terms and to generate consensus on the utilisation of a standardised nomenclature pertinent to the field...
October 2, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28797928/comparison-of-planar-pet-and-well-counter-measurements-of-total-tumor-radioactivity-in-a-mouse-xenograft-model
#19
Michael V Green, Jurgen Seidel, Mark R Williams, Karen J Wong, Anita Ton, Falguni Basuli, Peter L Choyke, Elaine M Jagoda
INTRODUCTION: Quantitative small animal radionuclide imaging studies are often carried out with the intention of estimating the total radioactivity content of various tissues such as the radioactivity content of mouse xenograft tumors exposed to putative diagnostic or therapeutic agents. We show that for at least one specific application, positron projection imaging (PPI) and PET yield comparable estimates of absolute total tumor activity and that both of these estimates are highly correlated with direct well-counting of these same tumors...
October 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28692851/a-simple-device-to-convert-a-small-animal-pet-scanner-into-a-multi-sample-tissue-and-injection-syringe-counter
#20
Michael V Green, Jurgen Seidel, Peter L Choyke, Elaine M Jagoda
INTRODUCTION: We describe a simple fixture that can be added to the imaging bed of a small-animal PET scanner that allows for automated counting of multiple organ or tissue samples from mouse-sized animals and counting of injection syringes prior to administration of the radiotracer. The combination of imaging and counting capabilities in the same machine offers advantages in certain experimental settings. METHODS: A polyethylene block of plastic, sculpted to mate with the animal imaging bed of a small-animal PET scanner, is machined to receive twelve 5-ml containers, each capable of holding an entire organ from a mouse-sized animal...
October 2017: Nuclear Medicine and Biology
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