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https://www.readbyqxmd.com/read/28431457/precision-medicine-and-pharmacogenetics-what-does-oncology-have-that-addiction-medicine-does-not
#1
Henry R Kranzler, Rachel V Smith, Robert Schnoll, Afaf Moustafa, Emma Greenstreet-Akman
BACKGROUND AND AIMS: Precision, personalized or stratified medicine, which promises to deliver the right treatment to the right patient, is a topic of international interest in both the lay press and the scientific literature. A key aspect of precision medicine is the identification of biomarkers that predict the response to medications (i.e. pharmacogenetics). We examined why, despite the great strides that have been made in biomarker identification in many areas of medicine, only in oncology has there been substantial progress in their clinical implementation...
April 21, 2017: Addiction
https://www.readbyqxmd.com/read/28431456/substance-and-behavioral-addictions-may-share-a-similar-underlying-process-of-dysregulation
#2
Steve Sussman, Dmitri Rozgonjuk, Regina J J M van den Eijnden
No abstract text is available yet for this article.
April 21, 2017: Addiction
https://www.readbyqxmd.com/read/28430388/associations-between-childhood-maltreatment-and-non-medical-use-of-prescription-drugs-among-chinese-adolescents
#3
Lan Guo, Yan Xu, Jianxiong Deng, Xue Gao, Guoliang Huang, Jinghui Huang, Xueqing Deng, Wei-Hong Zhang, Ciyong Lu
AIMS: To test, among Chinese adolescents: (1) whether childhood maltreatment is associated with non-medical use of prescription drugs (NMUPD), (2) whether there are interaction effects of childhood maltreatment and depressive symptoms on NMUPD. DESIGN: A secondary analysis of the cross-sectional data collected from 7(th) and 12(th) graders who were sampled using a multistage, stratified cluster, random sampling method in the 2015 School-based Chinese Adolescents Health Survey (SCAHS)...
April 21, 2017: Addiction
https://www.readbyqxmd.com/read/28430385/significant-reductions-in-alcohol-use-after-hepatitis-c-treatment-results-from-the-french-anrs-co13-hepavih-cohort
#4
Rod Knight, Perrine Roux, Antoine Vilotitch, Fabienne Marcellin, Eric Rosenthal, Laure Esterle, François Boué, David Rey, Lionel Piroth, Stéphanie Dominguez, Philippe Sogni, Dominique Salmon-Ceron, Bruno Spire, Maria Patrizia Carrieri
BACKGROUND AND AIMS: Few data exist on changes to substance use patterns before and after hepatitis C virus (HCV) treatment. We used longitudinal data of HIV-HCV co-infected individuals to examine whether receiving Peg-interferon (Peg-IFN)-based therapy irrespective of HCV clearance could modify tobacco, cannabis and alcohol use. DESIGN: A prospective cohort of HIV-HCV co-infected individuals was enrolled from 2006. Participants' clinical data were retrieved from medical records and socio-demographic and behavioral characteristics were collected by yearly self-administered questionnaires...
April 21, 2017: Addiction
https://www.readbyqxmd.com/read/28430384/pharmacokinetics-of-concentrated-naloxone-nasal-spray-over-first-30%C3%A2-minutes-post-dosing-analysis-of-suitability-for-opioid-overdose-reversal
#5
Gill Mundin, Rebecca McDonald, Kevin Smith, Stephen Harris, John Strang
BACKGROUND AND AIMS: Lack of non-injectable naloxone formulations has impeded widespread take-home provision for the prevention of heroin/opioid overdose deaths. For non-injectable formulations that are finally being investigated, rapid onset of action and sufficient bioavailability will be vital. We present analysis of data from a study of concentrated naloxone nasal spray formulations. Our aims are: to assess 1) pharmacokinetic properties and 2) suitability for overdose reversal in terms of naloxone absorption within 30 minutes post-dosing...
April 21, 2017: Addiction
https://www.readbyqxmd.com/read/28417504/the-coping-function-of-mental-disorder-symptoms-is-it-to-be-considered-when-developing-diagnostic-criteria-for-behavioural-addictions
#6
Barna Konkolÿ Thege
No abstract text is available yet for this article.
April 17, 2017: Addiction
https://www.readbyqxmd.com/read/28419659/making-visible-the-politics-and-ethics-of-alcohol-policy-research
#7
David Moore
Although research on alcohol policy has produced a huge international literature, alcohol research and policy itself-its cultural assumptions, methods, politics and ethics-has rarely been subject to critical analysis. In this article, I provide an appreciative review of an exception to this trend: Joseph Gusfield's 1981 classic, The Culture of Public Problems: Drinking-Driving and the Symbolic Order. I first outline Gusfield's argument that the 'problem of drinking-driving' is constructed as a 'drama of individualism' centring on the 'killer drunk'...
April 16, 2017: Addiction
https://www.readbyqxmd.com/read/28419656/cannabis-psychosis-and-schizophrenia-unravelling-a-complex-interaction
#8
Ian Hamilton
The relationship between cannabis and psychosis and schizophrenia has tested the field of addiction for decades, and in some ways serves as measure of our ability to provide a credible contribution to public health. As cannabis is used widely, many people are interested in the risks the drug poses to mental health. This paper focuses upon a seminal study examining this, the trajectory of subsequent research findings and what this has meant for understanding and communicating risk factor information. These studies provided evidence of a dose-response relationship between cannabis and psychosis, and that for those individuals with schizophrenia cannabis exacerbated their symptoms...
April 16, 2017: Addiction
https://www.readbyqxmd.com/read/28419617/behavioural-addiction-and-substance-addiction-should-be-defined-by-their-similarities-not-their-dissimilarities
#9
Mark D Griffiths
No abstract text is available yet for this article.
April 16, 2017: Addiction
https://www.readbyqxmd.com/read/28406579/disparities-in-pharmacotherapy-for-alcohol-use-disorder-in-the-context-of-universal-healthcare-a-swedish-register-study
#10
Katherine J Karriker-Jaffe, Jianguang Ji, Jan Sundquist, Kenneth S Kendler, Kristina Sundquist
BACKGROUND AND AIM: Pharmacotherapy can be an important part of the continuum of care for alcohol use disorder (AUD). The Swedish universal healthcare system emphasizes provision of care to marginalized groups. The primary aim was to test associations of neighbourhood deprivation and disadvantaged social status with receipt of AUD pharmacotherapy in this context. DESIGN: Data from linked population registers were used to follow an open cohort over 7 years. SETTING: Sweden...
April 12, 2017: Addiction
https://www.readbyqxmd.com/read/28393418/cannabis-use-and-crash-risk-in-drivers
#11
LETTER
Guohua Li, Charles J Dimaggio, Joanne E Brady
No abstract text is available yet for this article.
April 9, 2017: Addiction
https://www.readbyqxmd.com/read/28393411/response-to-li-et-al-2017-cannabis-use-and-crash-risk-in-drivers
#12
LETTER
Ole Rogeberg, Rune Elvik
No abstract text is available yet for this article.
April 9, 2017: Addiction
https://www.readbyqxmd.com/read/28390078/are-societies-paying-unnecessarily-for-an-otherwise-free-lunch-final-musings-on-the-research-on-alcoholics-anonymous-and-its-mechanisms-of-behavior-change
#13
https://www.readbyqxmd.com/read/28388836/coping-mediates-the-effects-of-cognitive-behavioral-therapy-for-alcohol-use-disorder-among-outpatient-clients-in-project-match-when-dependence-severity-is-high
#14
Corey Roos, Stephen A Maisto, Katie Witkiewitz
BACKGROUND AND AIMS: There is inconsistent evidence that alcohol-specific coping is a mechanism of change in cognitive-behavioral therapy (CBT) for alcohol use disorder (AUD). Our primary aim was to test whether baseline dependence severity moderates the mediational effect of CBT on drinking outcomes via coping. DESIGN: Secondary data analysis of Project MATCH (1), a multi-site alcohol treatment trial in which participants, recruited in outpatient and aftercare arms, were randomized to three treatments: CBT, motivational enhancement therapy (MET) and twelve-step facilitation (TSF)...
April 7, 2017: Addiction
https://www.readbyqxmd.com/read/28387979/prescription-contraception-use-and-adherence-by-women-with-substance-use-disorders
#15
Gillian Griffith, Tara Kumaraswami, Stavroula A Chrysanthopoulou, Kristin M Mattocks, Robin E Clark
BACKGROUND AND AIMS: Unintended pregnancy rates are high among women with substance use disorders (SUDs), which could be partly explained by lower use of and adherence to contraception. We aimed to test: (1) the association of SUD with prescription contraceptive use, contraceptive method selection, and adherence; (2) whether practices participating in the Patient-Centered Medical Home Initiative (PCMHI) had better contraceptive use and adherence for patients with SUD; (3) for differences in the association of SUD with adherence by type of contraceptive used...
April 7, 2017: Addiction
https://www.readbyqxmd.com/read/28387975/insular-and-cingulate-attenuation-during-decision-making-is-associated-with-future-transition-to-stimulant-use-disorder
#16
Jennifer L Stewart, Mamona Butt, April C May, Susan F Tapert, Martin P Paulus
AIMS: To understand processes placing individuals at risk for stimulant (amphetamine and cocaine) use disorder. DESIGN: Longitudinal study. SETTING: University of California, San Diego Department of Psychiatry, USA. PARTICIPANTS: Occasional stimulant users (OSU; n = 184) underwent a baseline clinical interview and a functional magnetic resonance imaging (fMRI) session. On the basis of a follow-up clinical interview completed three years later, OSU (n = 147) were then categorized as problem stimulant users (PSU: n = 36; those who developed stimulant use disorders in the interim) or desisted stimulant users (DSU: n = 74; those who stopped using)...
April 7, 2017: Addiction
https://www.readbyqxmd.com/read/28387964/the-role-of-novelty-seeking-as-a-predictor-of-substance-use-disorder-outcomes-in-early-adulthood
#17
James A Foulds, Joseph M Boden, Giles M Newton-Howes, Roger T Mulder, L John Horwood
BACKGROUND AND AIMS: There has been a great deal of evidence showing high novelty seeking (NS) is a risk factor for the development of substance use disorders (SUDs). However, the possible causal role of NS in SUDs is unconfirmed. The aim of this study was to examine the associations between NS at age 16 and SUDs from age 18 to 35 years, net of a series of covariate factors. DESIGN: Longitudinal study of a birth cohort from 1977 to 2012. SETTING: Christchurch, New Zealand...
April 7, 2017: Addiction
https://www.readbyqxmd.com/read/28345295/a-national-swedish-longitudinal-twin-sibling-study-of-alcohol-use-disorders-among-males
#18
E C Long, S L Lönn, J Sundquist, K Sundquist, K S Kendler
AIMS: To examine whether genetic influences on the development of alcohol use disorders (AUD) among men during emerging adulthood through mid-adulthood are stable or dynamic. DESIGN: A twin study modeling developmental changes in the genetic and environmental influences on AUD over three age periods (18-25, 26-33, and 33-41) as a Cholesky decomposition. SETTING: Sweden. PARTICIPANTS: Swedish male twin pairs (1,532 monozygotic and 1,940 dizygotic) and 66,033 full male sibling pairs born less than two years apart...
March 26, 2017: Addiction
https://www.readbyqxmd.com/read/28345281/correlates-of-alcohol-consumption-on-heavy-drinking-occasions-of-young-risky-drinkers-event-versus-personal-characteristics
#19
P Dietze, P A Agius, M Livingston, S Callinan, R Jenkinson, M S C Lim, C J C Wright, R Room
AIMS: Risky single occasion drinking (RSOD) by young people is a serious public health issue, yet little is known about the specific circumstances of risky drinking occasions. This study examined the independent effects of event- and individual-specific variables on RSOD. DESIGN: Longitudinal cohort study measuring self-reported RSOD and event- and individual-specific variables across two drinking occasions approximately one year apart. SETTING: Metropolitan Melbourne, Australia...
March 26, 2017: Addiction
https://www.readbyqxmd.com/read/28345169/alcohol-use-from-adolescence-through-early-adulthood-an-assessment-of-measurement-invariance-by-age-and-gender
#20
Jessica N Fish, Amanda M Pollitt, John E Schulenberg, Stephen T Russell
BACKGROUND AND AIMS: Studies on alcohol use and related constructs rarely test for measurement invariance to assess the reliability and validity of measures of alcohol use across different subpopulations of interest or ages. This failure to consider measurement invariance may result in biased parameter estimates and inferences. This study aimed to test measurement invariance of alcohol use across gender and age using a US-nationally representative sample to inform future longitudinal studies assessing alcohol use...
March 26, 2017: Addiction
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