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https://www.readbyqxmd.com/read/29781207/modelling-the-impact-of-a-national-scale-up-of-interventions-on-hepatitis-c-virus-transmission-among-people-who-inject-drugs-in-scotland
#1
H Fraser, C Mukandavire, N K Martin, D Goldberg, N Palmateer, A Munro, A Taylor, M Hickman, S Hutchinson, P Vickerman
BACKGROUND AND AIMS: To reduce hepatitis C virus (HCV) transmission among people who inject drugs (PWID), Scottish Government-funded national strategies, launched in 2008, promoted scaling-up opioid substitution therapy (OST) and needle and syringe provision (NSP), with some increases in HCV treatment. We test whether observed decreases in HCV incidence post-2008 can be attributed to this intervention scale-up. DESIGN: A dynamic HCV transmission model amongst PWID incorporating intervention scale-up and observed decreases in behavioural risk, calibrated to Scottish HCV prevalence and incidence data for 2008/09...
May 20, 2018: Addiction
https://www.readbyqxmd.com/read/29781091/fetal-assessment-in-buprenorphine-maintained-women-using-fetal-magnetoencephalography-a-pilot-study
#2
Diana Escalona-Vargas, Jessica L Coker, Shona Ray-Griffith, Eric R Siegel, Curtis L Lowery, Zachary N Stowe, Hari Eswaran
BACKGROUND AND AIMS: In-utero exposure to opioids including buprenorphine (BUP) has been shown to affect fetal activity, specifically heart-rate variability (FHRV) and fetal movement (FM). Our objective was to extract simultaneous recordings of fetal cardiac, and brain-related activity in BUP-maintained and non-opioid exposed pregnant women using a novel non-invasive biomagnetic technique. DESIGN: A pilot study was conducted, recording and analyzing biomagnetic data from fetuses of BUP-maintained and non-opioid exposed pregnant women...
May 20, 2018: Addiction
https://www.readbyqxmd.com/read/29774607/impact-of-current-and-scaled-up-levels-of-hepatitis-c-prevention-and-treatment-interventions-for-people-who-inject-drugs-in-three-uk-settings-what-is-required-to-achieve-the-who-s-hcv-elimination-targets
#3
Zoe Ward, Lucy Platt, Sedona Sweeney, Vivian D Hope, Lisa Maher, Sharon Hutchinson, Norah Palmateer, Josie Smith, Noel Craine, Avril Taylor, Natasha Martin, Rachel Ayres, John Dillon, Matthew Hickman, Peter Vickerman
AIMS: To estimate the impact of existing high-coverage needle and syringe provision (HCNSP, defined as obtaining more than one sterile needle and syringe per injection reported) and opioid substitution therapy (OST) on hepatitis C virus (HCV) transmission among people who inject drugs (PWID) in three UK settings and to determine required scale-up of interventions, including HCV treatment, needed to reach the World Health Organization (WHO) target of reducing HCV incidence by 90% by 2030...
May 17, 2018: Addiction
https://www.readbyqxmd.com/read/29766605/what-role-does-dopamine-really-play-in-tobacco-addiction
#4
EDITORIAL
Cristiano Chiamulera, Robert J West
No abstract text is available yet for this article.
May 15, 2018: Addiction
https://www.readbyqxmd.com/read/29756262/reducing-the-standard-serving-size-of-alcoholic-beverages-prompts-reductions-in-alcohol-consumption
#5
Inge Kersbergen, Melissa Oldham, Andrew Jones, Matt Field, Colin Angus, Eric Robinson
AIMS: To test whether reducing the standard serving size of alcoholic beverages would reduce voluntary alcohol consumption in a laboratory (study 1) and a real-world drinking environment (study 2). Additionally, we modelled the potential public health benefit of reducing the standard serving size of on-trade alcoholic beverages in the United Kingdom. DESIGN: Studies 1 and 2 were cluster-randomized experiments. In the additional study, we used the Sheffield Alcohol Policy Model to estimate the number of deaths and hospital admissions that would be averted per year in the United Kingdom if a policy that reduces alcohol serving sizes in the on-trade was introduced...
May 14, 2018: Addiction
https://www.readbyqxmd.com/read/29752754/reasons-for-ambivalence-about-accepting-addiction-as-a-reason-for-performing-euthanasia
#6
Wayne Hall, Malcolm Parker
No abstract text is available yet for this article.
May 11, 2018: Addiction
https://www.readbyqxmd.com/read/29749666/adverse-adult-consequences-of-different-alcohol-use-patterns-in-adolescence-an-integrative-analysis-of-data-to-age-30-years-from-four-australasian-cohorts
#7
Edmund Silins, L John Horwood, Jake M Najman, George C Patton, John W Toumbourou, Craig A Olsson, Delyse M Hutchinson, Louisa Degenhardt, David Fergusson, Denise Becker, Joseph M Boden, Rohan Borschmann, Maria Plotnikova, George J Youssef, Robert J Tait, Philip Clare, Wayne D Hall, Richard P Mattick
BACKGROUND AND AIMS: Studies have linked adolescent alcohol use with adverse consequences in adulthood; yet it is unclear how strong the associations are and to what extent they may be due to confounding. Our aim was to estimate the strength of association between different patterns of adolescent drinking and longer-term psychosocial harms taking into account individual, family, and peer factors. DESIGN: Participant-level data were integrated from four long running longitudinal studies: Australian Temperament Project; Christchurch Health and Development Study; Mater Hospital and University of Queensland Study of Pregnancy; Victorian Adolescent Health Cohort Study...
May 10, 2018: Addiction
https://www.readbyqxmd.com/read/29749059/global-statistics-on-alcohol-tobacco-and-illicit-drug-use-2017-status-report
#8
REVIEW
Amy Peacock, Janni Leung, Sarah Larney, Samantha Colledge, Matthew Hickman, Jürgen Rehm, Gary A Giovino, Robert West, Wayne Hall, Paul Griffiths, Robert Ali, Linda Gowing, John Marsden, Alize J Ferrari, Jason Grebely, Michael Farrell, Louisa Degenhardt
AIMS: This review provides an up-to-date curated source of information on alcohol, tobacco, and illicit drug use and their associated mortality and burden of disease. Limitations in the data are also discussed, including how these can be addressed in the future. METHODS: Online data sources were identified through expert review. Data were mainly obtained from the World Health Organization, United Nations Office on Drugs and Crime, and Institute for Health Metrics and Evaluation...
May 10, 2018: Addiction
https://www.readbyqxmd.com/read/29744956/imaging-resilience-and-recovery-in-alcohol-dependence
#9
REVIEW
Katrin Charlet, Annika Rosenthal, Falk W Lohoff, Andreas Heinz, Anne Beck
BACKGROUND AND AIMS: Resilience and recovery are of increasing importance in the field of alcohol dependence (AD). This paper describes how imaging studies in man can be used to assess the neurobiological correlates of resilience and, if longitudinal, of disease trajectories, progression rates and markers for recovery to inform treatment and prevention options. METHODS: Original articles on recovery and resilience in alcohol addiction and its neurobiological correlates were identified from 'PubMed' and have been analyzed and condensed within a systematic literature review...
May 9, 2018: Addiction
https://www.readbyqxmd.com/read/29744945/understanding-the-development-of-a-regulated-market-approach-to-new-psychoactive-substances-nps-in-new-zealand-using-punctuated-equilibrium-theory
#10
Marta Rychert, Chris Wilkins
BACKGROUND AND AIMS: The short-lived regulated legal market for new psychoactive substances (NPS) in New Zealand marked a radical departure from the traditional prohibition-based approach. This paper aimed to enhance understanding of this policy change using Punctuated Equilibrium Theory (PET). METHODS: The analysis draws on three years of evaluative research, including interviews with key stakeholders, analysis of legislation and policy documents and academic and grey literature...
May 9, 2018: Addiction
https://www.readbyqxmd.com/read/29714034/cannabidiol-reverses-attentional-bias-to-cigarette-cues-in-a-human-experimental-model-of-tobacco-withdrawal
#11
C Hindocha, T P Freeman, M Grabski, J B Stroud, H Crudgington, A C Davies, R K Das, W Lawn, C J A Morgan, H V Curran
BACKGROUND AND AIMS: Cannabidiol (CBD), a non-intoxicating cannabinoid, may be a promising novel smoking cessation treatment due to its anxiolytic properties, minimal side-effects and research showing it may modify drug cue salience. We used an experimental medicine approach with dependent cigarette smokers to investigate if (1) overnight nicotine abstinence, compared with satiety, will produce greater attentional bias (AB), higher pleasantness ratings of cigarette-related stimuli and increased craving and withdrawal; (2) CBD in comparison to placebo, would attenuate AB, pleasantness of cigarette-related stimuli, craving and withdrawal and not produce any side-effects...
May 1, 2018: Addiction
https://www.readbyqxmd.com/read/29707859/does-early-exposure-to-caffeine-promote-smoking-and-alcohol-use-behavior-a-prospective-analysis-of-middle-school-students
#12
Alfgeir L Kristjansson, Steven M Kogan, Michael J Mann, Megan L Smith, Laura M Juliano, Christa L Lilly, Jack E James
BACKGROUND AND AIMS: Despite the negative consequences associated with caffeine use among children and youth, its use is increasingly widespread among middle school students. Cross-sectional studies reveal links between caffeine and other substance use. The potential for caffeine use to confer increased vulnerability to substance use, however, has not been investigated using prospective designs. We hypothesized that caffeine use at baseline would be positively associated with increased alcohol use, drunkenness, smoking, and e-cigarette use...
April 30, 2018: Addiction
https://www.readbyqxmd.com/read/29697879/drawing-attention-to-a-neglected-injecting-related-harm-a-systematic-review-of-aa-amyloidosis-among-people-who-inject-drugs
#13
REVIEW
Magdalena Harris, Rachel Brathwaite, Jenny Scott, Gail Gilchrist, Dan Ciccarone, Vivian Hope, Catherine R McGowan
BACKGROUND AND AIMS: Chronic skin and soft tissue infections (SSTI) among people who inject drugs (PWID) can lead to AA-amyloidosis: a serious, yet neglected, multi-organ disease. We aim to synthesise findings on the epidemiology, risk factors, clinical outcomes, screening recommendations, and challenges to treatment for AA-amyloidosis among PWID. METHODS: A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)...
April 26, 2018: Addiction
https://www.readbyqxmd.com/read/29696713/national-cancer-societies-and-their-public-statements-on-alcohol-consumption-and-cancer-risk
#14
Gopal Amin, Michael Siegel, Timothy Naimi
BACKGROUND AND AIMS: Studies have shown that alcohol consumption is a risk factor for oral, pharyngeal, laryngeal, esophageal, liver, colon, rectal, and breast cancer. It would therefore be expected that cancer prevention organizations would incorporate these facts into their public stance on the consumption of alcohol. The aims of this study were to: 1) assess how national cancer societies in developed English-speaking countries (i.e., English-speaking countries belonging to the Organization for Economic Co-operation and Development (OECD)) communicate alcohol-related cancer risk to the public and 2) compare whether these organization's advocacy of increased alcohol taxes is in line with their advocacy of tobacco tax increases to reduce cancer risk...
April 25, 2018: Addiction
https://www.readbyqxmd.com/read/29691937/testing-associations-between-cannabis-use-and-subcortical-volumes-in-two-large-population-based-samples
#15
Nathan A Gillespie, Michael C Neale, Timothy C Bates, Lisa T Eyler, Christine Fennema-Notestine, Jasmin Vassileva, Michael J Lyons, Elizabeth C Prom-Wormley, Katie L McMahon, Paul M Thompson, Greig de Zubicaray, Ian B Hickie, John J McGrath, Lachlan T Strike, Miguel E Rentería, Matthew S Panizzon, Nicholas G Martin, Carol E Franz, William S Kremen, Margaret J Wright
BACKGROUND AND AIMS: Disentangling the putative impact of cannabis on brain morphology from other comorbid substance use is critical. After controlling for the effects of nicotine, alcohol and multi-substance use, this study aimed to determine whether frequent cannabis use is associated with significantly smaller subcortical grey matter volumes. DESIGN: Exploratory analyses using mixed linear models, one per region of interest (ROI), were performed whereby individual differences in volume (outcome) at seven subcortical ROIs were regressed onto cannabis and comorbid substance use (predictors)...
April 24, 2018: Addiction
https://www.readbyqxmd.com/read/29679954/are-changes-in-drinking-related-to-changes-in-cannabis-use-among-swedish-adolescents-a-time-series-analysis-for-the-period-1989-2016
#16
Isabella Gripe, Anna-Karin Danielsson, Mats Ramstedt
AIMS: To examine if changes in alcohol consumption are associated with changes in cannabis use among Swedish adolescents in a period of diverging trends, and to investigate if cannabis and alcohol act as complements or substitutes. DESIGN, SETTING, PARTICIPANTS AND MEASUREMENTS: Data comprise a nationally representative annual school survey of alcohol and drug habits among Swedish 9th grade students (15-16 years) covering the years 1989-2016 (n=149 603). Alcohol and cannabis use were measured concurrently and alcohol consumption was measured in liters of 100% alcohol per year...
April 21, 2018: Addiction
https://www.readbyqxmd.com/read/29679432/an-rct-with-the-combination-of-varenicline-and-bupropion-for-smoking-cessation-clinical-implications-for-front-line-use
#17
Paul M Cinciripini, Jennifer A Minnix, Charles E Green, Jason D Robinson, Jeffrey M Engelmann, Francesco Versace, David W Wetter, Sanjay Shete, Maher Karam-Hage
BACKGROUND AND AIMS: Despite the availability of several efficacious smoking cessation treatments, less than 25% of smokers who quit remain abstinent 1 year post treatment. This study aimed to determine if varenicline and bupropion combination treatment would result in higher abstinence rates than varenicline alone. DESIGN: A double-blind, randomized, parallel groups smoking cessation clinical trial in which participants were exposed to 12 weeks of treatment and followed for 12 months...
April 21, 2018: Addiction
https://www.readbyqxmd.com/read/29679419/sexual-orientation-differences-in-alcohol-use-trajectories-and-disorders-in-emerging-adulthood-results-from-a-longitudinal-cohort-study-in-the-united-states
#18
Robert W S Coulter, Hee-Jin Jun, Jerel P Calzo, Nhan L Truong, Christina Mair, Nina Markovic, Brittany M Charlton, Anthony J Silvestre, Ron Stall, Heather L Corliss
AIMS: We estimated sexual-orientation differences in alcohol use trajectories during emerging adulthood, and tested whether alcohol use trajectories mediated sexual-orientation differences in alcohol use disorders (AUDs). DESIGN: Longitudinal self-reported survey data from the Growing Up Today Study. SETTING: USA. PARTICIPANTS: 12,493 participants aged 18-25 during the 2003, 2005, 2007, or 2010 surveys. MEASUREMENTS: Stratified by gender, longitudinal latent class analyses estimated alcohol use trajectories (using past-year frequency, quantity, and binge drinking from 2003-2010)...
April 21, 2018: Addiction
https://www.readbyqxmd.com/read/29679440/effects-of-a-prior-authorization-policy-for-extended-release-long-acting-opioids-on-utilization-and-outcomes-in-a-state-medicaid-program
#19
Shellie L Keast, Hyunjee Kim, Richard A Deyo, Luke Middleton, K John McConnell, Kun Zhang, Sharia M Ahmed, Nancy Nesser, Daniel M Hartung
BACKGROUND AND AIMS: In response to the opioid overdose epidemic, USA state Medicaid programs have adopted restrictive policies for opioid analgesics, yet effects on prescribing patterns and health outcomes are uncertain. This study aimed to examine effects of a prior authorization policy for extended-release/long-acting (ER/LA) opioids on opioid use in the Oklahoma, USA state Medicaid program. DESIGN: Retrospective difference-in-differences design study comparing changes in opioid use in Oklahoma Medicaid to control (Oregon Medicaid)...
April 20, 2018: Addiction
https://www.readbyqxmd.com/read/29676824/the-safety-effectiveness-and-cost-effectiveness-of-cytisine-in-achieving-six-month-continuous-smoking-abstinence-in-tuberculosis-patients-protocol-for-a-double-blind-placebo-controlled-randomised-trial
#20
Omara Dogar, Deepa Barua, Melanie Boeckmann, Helen Elsey, Razia Fatima, Rhian Gabe, Rumana Huque, Ada Keding, Amina Khan, Daniel Kotz, Eva Kralikova, James N Newell, Iveta Nohavova, Steve Parrott, Anne Readshaw, Lottie Renwick, Aziz Sheikh, Kamran Siddiqi
BACKGROUND AND AIMS: Tuberculosis (TB) patients who quit smoking have much better disease outcomes than those who continue to smoke. Behavioural support combined with pharmacotherapy is the most effective strategy in helping people to quit, in general populations. However, there is no evidence for the effectiveness of this strategy in TB patients who smoke. We will assess the safety, effectiveness and cost-effectiveness of cytisine - a low-cost plant-derived nicotine substitute - for smoking cessation in TB patients compared with placebo, over and above brief behavioural support...
April 20, 2018: Addiction
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