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Acta Pharmaceutica

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https://www.readbyqxmd.com/read/28590914/porphyra-334-a-mycosporine-like-amino-acid-attenuates-uv-induced-apoptosis-in-hacat-cells
#1
Sung-Suk Suh, Se Kyung Oh, Sung Gu Lee, Il-Chan Kim, Sanghee Kim
The main aim of the current research was to study the effect of porphyra-334, one of mycosporine-like amino acids (MAAs), well known as UV-absorbing compounds, on UVinduced apoptosis in human immortalized keratinocyte (HaCaT) cells. Due to their UV-screening capacity and ability to prevent UV-induced DNA damage, MAAs have recently attracted considerable attention in both industry and research in pharmacology. Herein, human HaCaT cells were used to determine the biological activities of porphyra- 334 by various in vitro assays, including proliferation, apoptosis and Western blot assays...
June 27, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28590913/testing-of-resveratrol-microemulsion-photostability-and-protective-effect-against-uv-induced-oxidative-stress
#2
Vaida Juškaitė, Kristina Ramanauskienė, Vitalis Briedis
Resveratrol is well known for its antioxidant activity and susceptibility to ultraviolet radiation. Development of formulations providing improved stability and relevant drug delivery of resveratrol is still a challenging task. The aim of this study was to determine protective characteristics of formulated microemulsions by evaluating photoisomerization of resveratrol and to investigate the effects of resveratrol on human keratinocyte cells under oxidative stress caused by ultraviolet radiation. Incorporation of resveratrol into microemulsions resulted in increased photostability of active compounds and the results demonstrated that photodegradation of resveratrol was significantly delayed...
June 27, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28590912/quantitative-analysis-of-povidone-iodine-thin-films-by-x-ray-photoelectron-spectroscopy-and-their-physicochemical-properties
#3
Anongtip Sa, Somchai Sawatdee, Narubodee Phadoongsombut, Wilaiporn Buatong, Titpawan Nakpeng, Rutthapol Sritharadol, Teerapol Srichana
In this study, povidone-iodine (PVP-I) has been formulated as a topical spray to produce a thin film for the controlled release of I2. By means of experimental design, 27 formulations containing glycerol, ethanol, PEG 400, copovidone and HFA 134a as a propellant were prepared. The pH values of all formulations were in the range of 6-7. The viscosity was within the range of 11.9-85.9 mPa s. The surface tensions were 20.3 to 24.6 mN m-1 and the contact angles were between 19.3 and 38.7°. The assays for the iodine contents were within acceptable range (80-120 %)...
June 27, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28590911/effect-of-%C3%AE-ethyl-%C3%AE-phenyl-butyrolactone-efbl-anticonvulsant-and-hypnotic-drug-on-mouse-brain-catecholamine-levels
#4
Lourdes A Vega Rasgado, Iván Villanueva, Fernando Vega Díaz
γ-Ethyl-γ-phenyl-butyrolactone (EFBL) is a structural combination of the anticonvulsant γ-hydroxy-γ-ethyl-γ-phenylbutyramide (HEPB) and the hypnotic γ-butyrolactone (GBL), which inherits both properties. To clarify its mechanism of action, the effects of EFBL, GBL and HEPB on dopamine (DA) and noradrenaline (NA) brain levels were investigated. Influences of chlorpromazine, phenelzine and aminooxyacetic acid were also studied. EFBL increased DA in a dose-dependent manner, remaining enhanced by 80 % over a period of 24 h and augmented NA by 54 % one hour after treatment...
June 27, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28590910/application-of-sedem-expert-systems-in-preformulation-studies-of-pediatric-ibuprofen-odt-tablets
#5
Emese Sipos, Andrea Ramona Oltean, Zoltán-István Szabó, Emőke-Margit Rédai, Gabriella Dónáth Nagy
Pediatric, ibuprofen containing orodispersible tablets (ODTs) were prepared using the SeDeM expert system methodology. In order to facilitate formulation, directly compressible ibuprofen was employed (Ibuprofen DC 8TM) and characterized using its SeDeM profile. The mannitol based superdisintegrant Ludiflash® was characterized by the SeDeM-ODT expert system, which also allowed calculation of the optimal excipient concentration in order to obtain suitable tablet hardness and disintegration time. After adding a sweetener and a standard combination of lubricants, the optimized formulation was directly compressed into tablets and evaluated in terms of tablet hardness, friability, disintegration time and dissolution profile...
June 27, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28590909/comparing-monolithic-and-fused-core-hplc-columns-for-fast-chromatographic-analysis-of-fat-soluble-vitamins
#6
Said El Kurdi, Dina Abu Muaileq, Hassan A Alhazmi, Mohammed Al Bratty, Sami El Deeb
HPLC stationary phases of monolithic and fused core type can be used to achieve fast chromatographic separation as an alternative to UPLC. In this study, monolithic and fused core stationary phases are compared for fast separation of four fat-soluble vitamins. Three new methods on the first and second generation monolithic silica RP-18e columns and a fused core pentafluoro-phenyl propyl column were developed. Application of three fused core columns offered comparable separations of retinyl palmitate, DL-α-tocopheryl acetate, cholecalciferol and menadione in terms of elution speed and separation efficiency...
June 27, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28590908/biomimetic-insulin-imprinted-polymer-nanoparticles-as-a-potential-oral-drug-delivery-system
#7
Pijush Kumar Paul, Alongkot Treetong, Roongnapa Suedee
In this study, we investigate molecularly imprinted polymers (MIPs), which form a three-dimensional image of the region at and around the active binding sites of pharmaceutically active insulin or are analogous to b cells bound to insulin. This approach was employed to create a welldefined structure within the nanospace cavities that make up functional monomers by cross-linking. The obtained MIPs exhibited a high adsorption capacity for the target insulin, which showed a significantly higher release of insulin in solution at pH 7...
June 27, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28590907/real-practice-thromboprophylaxis-in-atrial-fibrillation
#8
Paola Deambrosis, Alessandra Bettiol, Jenny Bolcato, Roberta Pirolo, Giulia Franchin, Sakis Themistoclakis, Michele Pellizzari, Alessandro Chinellato, Pietro Giusti
This retrospective observational study was based on databases of the Local Health Authority of Treviso, Italy. It evaluated the prevalence and the effectiveness of oral anticoagulation treatment (OAT) for the management of nonvalvular atrial fibrillation (NVAF) in everyday clinical practice. Out of 6,138 NVAF patients, only 3,024 received vitamin K antagonist (VKA). Potential barriers decreasing the probability of being treated with VKA were female sex, older age, antiplatelet treatment and history of bleeding...
June 27, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28590906/influence-of-concentration-and-type-of-microcrystalline-cellulose-on-the-physical-properties-of-tablets-containing-cornelian-cherry-fruits
#9
Aleš Franc, Slavomir Kurhajec, Sylvie Pavloková, Dana Sabadková, Jan Muselík
The aim of this study was to find the optimal tablet composition with maximum content of dried fruits (Cornus mas L.). The effect of three different concentrations (12.5, 25 and 50 %) of two types of microcrystalline cellulose (Avicel® PH 101 and Avicel® PH 200) and three different compression pressures (20, 60 and 100 MPa) on the physical properties of tablet blends and tablets was studied. Tablets containing 50 % Avicel® PH 101 compressed under 100 MPa were found to have the best physical properties. This combination of composition and compression pressure resulted in stable tablets even after storage under accelerated stability conditions (6 months, 40 °C and 75 % RH)...
June 27, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28590905/the-bioguided-fractionation-and-pharmacological-activity-of-an-endemic-salix-canariensis-species
#10
Sandra Dévora Gutiérrez, Susana Abdala Kuri, Domingo Martín-Herrera
The present study was designed to confirm the wide traditional use of treating pain with Salix canariensis, an endemic species of the Macaronesian region. The active compounds were identified. Pharmacological activities were explored in experimental animals by acetic acid-induced writhing, formalin and Levy's tests, and bioactive compounds were identified after a bio-guided fractionation of the most active organic extract. S. canariensis extract, orally administrated at different doses, led to a significant reduction in writhing, caused a moderate decrease of formalin-induced pain and revealed an excellent dose-dependent anti-inflammatory effect...
June 27, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28231053/original-research-paper-synthesis-and-antitumor-activity-of-some-novel-thiophene-pyrimidine-coumarin-pyrazole-and-pyridine-derivatives
#11
Mohammed Albratty, Karam Ahmed El-Sharkawy, Shamsher Alam
No abstract text is available yet for this article.
March 1, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28231052/review-the-role-of-peroxisome-proliferator-activated-receptor-in-the-treatment-of-non-alcoholic-fatty-liver-disease
#12
REVIEW
Xin Sun, Yan Zhang, Meilin Xie
Non-alcoholic fatty liver disease (NAFLD) has been defined as a spectrum of histological abnormalities and is characterized by significant and excessive accumulation of triglycerides in the hepatocytes in patients without alcohol consumption or other diseases. Current studies are targeting new molecular mechanisms that underlie NAFLD and associated metabolic disorders. Many therapeutic targets have been found and used in clinical studies. Peroxisome proliferator-activated receptors (PPARs) are among the potential targets and have been demonstrated to exert a pivotal role in modulation of NAFLD...
March 1, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28231051/short-communication-challenges-relating-to-comparison-of-flavonoid-glycosides-dissolution-profiles-from-sutherlandia-frutescens-products
#13
COMPARATIVE STUDY
Oluchi N Mbamalu, James Syce, Halima Samsodien
Unlike the case of conventional drug formulations, dissolution tests have hitherto not been required for herbal medicinal products commercially available in South Africa. This study investigated dissolution of the South African Sutherlandia frutescens using selected flavonoid glycosides as marker compounds. Dissolution of markers was assessed in three dissolution media at pH 1.2, 4.5 and 6.8, and samples were analysed using a validated HPLC method. The dissolution profile of each marker varied for the different materials investigated...
March 1, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28231050/original-research-paper-pulmonary-prophylactic-impact-of-melatonin-and-or-quercetin-a-novel-therapy-for-inflammatory-hypoxic-stress-in-rats
#14
Nouf M Al-Rasheed, Laila Fadda, Hala A Attia, Iman A Sharaf, Azza M Mohamed, Nawal M Al-Rasheed
The study aims to compare, through histological and biochemical studies, the effects of quercetin, melatonin and their combination in regulation of immuno-inflammatory mediators and heat shock protein expressions in sodium nitrite induced hypoxia in rat lungs. The results revealed that NaNO2 injection caused a significant decrease in Hb in rats, while serum levels of TNF-α, IL-6 and CRP, VEGF and HSP70 were elevated compared to the control group. Administration of melatonin, quercetin or their combination before NaNO2 injection markedly reduced these parameters...
March 1, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28231049/original-research-paper-hydrazinyldiene-chroman-2-4-diones-in-inducing-growth-arrest-and-apoptosis-in-breast-cancer-cells-synergism-with-doxorubicin-and-correlation-with-physicochemical-properties
#15
Lulzime Ballazhi, Faik Imeri, Ahmed Jashari, Emil Popovski, Goran Stojković, Aleksandar J Dimovski, Bozhana Mikhova, Kristina Mladenovska
This study evaluates the effects of previously synthesized hydrazinyldiene-chroman-2,4-diones on cell proliferation and apoptosis, cell cycle distribution and migration capacity of MCF-7 breast cancer cells in synergy with doxorubicin. Physicochemical properties of the synthesized compounds were correlated with their structure and activity. Significant cell viability decrease in comparison with the effect of doxorubicin alone and the reference 4-hydroxycoumarin was observed when combination treatment comprising doxorubicin and the title compounds was applied...
March 1, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28231048/original-research-paper-formulation-and-pharmaceutical-development-of-quetiapine-fumarate-sustained-release-matrix-tablets-using-a-qbd-approach
#16
COMPARATIVE STUDY
Alexandru Gavan, Alina Porfire, Cristina Marina, Ioan Tomuta
The main objective of the present study was to apply QbD methodology in the development of once-a-day sustained release quetiapine tablets. The quality target product profile (QTPP) was defined after the pharmaceutical properties and kinetic release of the innovator product, Seroquel XR 200 mg. For the D-optimal experimental design, the level and ratio of matrix forming agents and the type of extragranular diluent were chosen as independent inputs, which represented critical formulation factors. The critical quality attributes (CQAs) studied were the cumulative percentages of quetiapine released after certain time intervals...
March 1, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28231047/original-research-paper-characterization-and-taste-masking-evaluation-of-microparticles-with-cetirizine-dihydrochloride-and-methacrylate-based-copolymer-obtained-by-spray-drying
#17
Aleksandra Amelian, Marta Szekalska, Patrycja Ciosek, Anna Basa, Katarzyna Winnicka
Taste of a pharmaceutical formulation is an important parameter for the effectiveness of pharmacotherapy. Cetirizine dihydrochloride (CET) is a second-generation antihistamine that is commonly administered in allergy treatment. CET is characterized by extremely bitter taste and it is a great challenge to successfully mask its taste; therefore the goal of this work was to formulate and characterize the microparticles obtained by the spray drying method with CET and poly(butyl methacrylate-co-(2-dimethylaminoethyl) methacrylate-co-methyl methacrylate 1:2:1 copolymer (Eudragit E PO) as a barrier coating...
March 1, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28231046/original-research-paper-a-superior-preparation-method-for-daidzein-hydroxypropyl-%C3%AE-cyclodextrin-complexes-with-improved-solubility-and-dissolution-supercritical-fluid-process
#18
COMPARATIVE STUDY
Hao Pan, Han-Bing Wang, Yi-Bin Yu, Bing-Chao Cheng, Xiao-Yu Wang, Ying Li
Advantages of the supercritical fluid (SCF) process compared to the conventional solution stirring method (CSSM) in the preparation of daidzein-hydroxypropyl-β-cyclodextrin (HPβCD) complexes were investigated. Formation of daidzein/ HPβCD inclusion complexes was confirmed by Fourier transformed-infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and scanning electron microscopy (SEM). Particle size, inclusion yield, drug solubility and dissolution of daidzein/HPβCD complexes were evaluated...
March 1, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28231045/original-research-paper-public-health-care-system-a-quasi-experimental-study-acceptance-and-attitude-to-implicate-clinical-services
#19
Syed Wasif Gillani, Mohi Iqbal Mohammad Abdul
A six-month longitudinal intervention arm study with a pre-post cross-sectional questionnaire-based survey was performed. A 3-phase objective structured clinical examination (OSCE) design was utilized for evaluation of acceptance and attitude of pharmacy students towards clinical pharmacy services. The pre-OSCE survey showed increased disagreement with the role of clinical pharmacists, compared to a significant positive shift in attitude towards their services in the healthcare team after 6 months of the trial...
March 1, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28231044/original-research-paper-switching-antipsychotics-results-of-16-month-non-interventional-prospective-observational-clinical-research-of-inpatients-with-schizophrenia-spectrum-disorders
#20
COMPARATIVE STUDY
Cvetka Bačar Bole, Mitja Pišlar, Metka Šen, Rok Tavčar, Aleš Mrhar
The study aims to identify prescribing and switching patterns of antipsychotics in clinical practice. A 16-month, prospective study was conducted at the Psychiatric Hospital Idrija, Slovenia. Inpatients (N = 311) with schizophrenia spectrum disorders were observed. The causes for switching antipsychotics and switching strategies were analyzed. Analyzing a total of 3954 prescriptions, the collected data confirmed that treatment strategies in this psychiatric hospital are very complex. It was found that 37 percent of inpatients had at least one switch...
March 1, 2017: Acta Pharmaceutica
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