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Acta Pharmaceutica

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https://www.readbyqxmd.com/read/29453917/comparative-chemical-investigation-and-evaluation-of-antioxidant-and-tyrosinase-inhibitory-effects-of-withania-somnifera-l-dunal-and-solanum-nigrum-l-berries
#1
Abdul Hameed, Naveed Akhtar
In the present study, berries of two different species of Solanaceae family, Withania somnifera (WS) and Solanum nigrum (SN), were extracted in methanol and then fractionated with solvents, ranging from non-polar to polar, for their phytochemical profiling and investigation of antioxidant and tyrosinase enzyme inhibition capacity. The methanolic extract and n-hexane, ethyl acetate (WSEA, SNEA) and aqueous fractions were chemically analyzed and evaluated for biological activity. Total flavonoids and total phenolics were quantified in WSEA (96...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453916/distinguishing-smilax-glabra-and-smilax-china-rhizomes-by-flow-injection-mass-spectrometry-combined-with-principal-component-analysis
#2
Jian Liang, Meng Zhou, Lin-Yu Li, Ji-Cheng Shu, Yong-Hong Liang, Feng-Qin Li, Li Xiong, Hui-Lian Huang
Flow-injection mass spectrometry (FIMS) coupled with a chemometric method is proposed in this study to profile and distinguish between rhizomes of Smilax glabra (S. glabra) and Smilax china (S. china). The proposed method employed an electrospray-time-of-flight MS. The MS fingerprints were analyzed using principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) with the aid of SIMCA software. Findings showed that the two kinds of samples perfectly fell into their own classes...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453915/efficacy-of-nucleoside-analogues-for-hepatitis-b-virus-related-liver-failure-a-network-meta-analysis
#3
Jian Wu, Fang Yin, Xinmin Zhou
The purpose of this study was to compare the efficacy of nucleoside analogues (NAs) in the treatment of HBV-related liver failure. The data of patients with HBV-related liver failure treated with nucleoside analogues were used to conduct a network meta-analysis. A total of 1660 patients from 12 articles about the efficacy of lamivudine, entecavir, telbivudine and tenofovir for HBV-related liver failure treatment were recruited in the study. The highest two- and three-month survival rate was recorded for patients using tenofovir...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453914/medication-adherence-and-health-related-quality-of-life-among-patients-with-chronic-obstructive-pulmonary-disease
#4
Nejc Horvat, Igor Locatelli, Mitja Kos, Ana Janežič
This study evaluated medication adherence and health-related quality of life (HRQoL) of Slovenian patients with chronic obstructive pulmonary disease (COPD) and examined the factors associated with HRQoL. Demographic and therapy information was collected from 65 patients through interviews. The St. George's Respiratory Questionnaire and the Morisky Medication Adherence Scale were used to evaluate HRQoL and adherence, resp. A multiple linear regression model was used to assess the association between the factors and HRQoL...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453913/chronic-fluoxetine-treatment-induces-lipid-accumulation-but-does-not-alter-the-expression-of-pref-1-in-rat-adipose-tissue
#5
László-István Bába, Zsolt Gáll, István Lóránt Bíró, Tibor Mezei, Imre Zoltán Kun, Melinda Kolcsár
This study aims to investigate the effects of chronic fluoxetine (FLX) treatment on preadipocyte factor-1 (Pref-1) expression in subcutaneous, visceral and brown adipose tissues, and on the size of vacuoles in a dipocytes obtained from the perirenal regions in rats. Twenty-eight Wistar rats were treated with FLX at two different doses and fourteen animals received vehicle. After 40 days of treatment, the subcutaneous, perirenal and interscapular adipose tissues were collected. Pref-1 expression was examined using an immunohistochemical method and the vacuolar area was measured in stained sections...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453912/hptlc-determination-of-diosgenin-in-fenugreek-seeds
#6
Barbara Król-Kogus, Khenifi Mohammed Lamine, Piotr Migas, Messaoud Boudjeniba, Mirosława Krauze-Baranowska
A new HPTLC-densitometric method for diosgenin determination in fenugreek seeds was established after optimization of the conditions for efficient saponin extraction and acid hydrolysis. Several procedures were tested, the best of which was a three-step Soxhlet extraction, followed by hydrolysis of the obtained methanolic extract with 2 mol L-1 H2SO4. Best diosgenin separation from other hydrolysis products was obtained on HPTLC Si60F254 plates u sing a mixture of n-heptane/ethyl acetate (7:3, V/V) and modified anisaldehyde as a spraying reagent...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453911/induction-of-xenobiotic-metabolizing-enzymes-in-hepatocytes-by-beta-naphthoflavone-time-dependent-changes-in-activities-protein-and-mrna-levels
#7
Kateřina Lněničková, Lenka Skálová, Lucie Stuchlíková, Barbora Szotáková, Petra Matoušková
In the present study, time-dependency of the induction effect of a selective inducer on the activity, protein and mRNA levels of cytochromes P450 1A1/2 (CYP1A1/2), NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione S-transferases (GSTA), in primary culture of rat hepatocytes was tested and evaluated. To show the differences in responses of tested enzymes, the common aryl hydrocarbon receptor (AhR) ligand agonist, beta-naphthoflavone (BNF), was used. Induction of CYP1A1/2 by BNF was detected at all time intervals and at all levels (i...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453910/advanced-spectrophotometric-chemometric-methods-for-resolving-the-binary-mixture-of-doxylamine-succinate-and-pyridoxine-hydrochloride
#8
Plamen Katsarov, Georgi Gergov, Aylin Alin, Bissera Pilicheva, Yahya Al-Degs, Vasil Simeonov, Margarita Kassarova
The prediction power of partial least squares (PLS) and multivariate curve resolution-alternating least squares (MCR-ALS) methods have been studied for simultaneous quantitative analysis of the binary drug combination - doxylamine succinate and pyridoxine hydrochloride. Analysis of first-order UV overlapped spectra was performed using different PLS models - classical PLS1 and PLS2 as well as partial robust M-regression (PRM). These linear models were compared to MCR-ALS with equality and correlation constraints (MCR-ALS-CC)...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453909/a-headspace-gas-chromatography-method-for-isopropanol-determination-in-warfarin-sodium-products-as-a-measure-of-drug-crystallinity
#9
Ziyaur Rahman, Sohail Akhtar, Akhtar Siddiqui, Anthony B Ciavarella, Agnes Nguyenpho, Patrick J Faustino, Mansoor A Khan
Coumadin® a nd s everal generic products of warfarin s odium (WS) contain the crystalline form (clathrate) in which WS and isopropanol (IPA) are associated in a 2:1 molar ratio. IPA is critical in maintaining the WS crystalline structure. Physicochemical properties of the drug and drug product may change when the crystalline drug transforms to amorphous form. A headspace-gas chromatography (HS-GC) method was developed and validated for IPA determination in the WS drug product. n-propanol (NPA) was used as internal standard and the method was validated for specificity, system suitability, linearity, accuracy, precision, range, limits of detection and quantification, and robustness...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453908/effective-anti-adhesives-of-uropathogenic-escherichia-coli
#10
Rosana Ribić, Tomislav Meštrović, Marijana Neuberg, Goran Kozina
Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are among the most common infectious diseases in humans. Due to their frequent occurrence in the community and nosocomial settings, as well as the development of resistance to the commonly prescribed antimicrobial agents, an enormous financial burden is placed on healthcare systems around the world. Therefore, novel approaches to the prevention and treatment of UTIs are needed. Although UPEC may harbour a plethora of virulence factors, type I fimbriae and P pili are two of the most studied adhesive organelles, since the attachment to host cells in the urinary tract is a crucial step towards infection...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29337677/synthesis-and-cytotoxicity-evaluation-of-thiazole-derivatives-obtained-from-2-amino-4-5-6-7-tetrahydrobenzo-b-thiophene-3-carbonitrile
#11
Rafat M Mohareb, Amira E M Abdallah, Ebtsam A Ahmed
Reactivity of 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3- carbonitrile towards thioglycolic acid resulted in thiazole derivative 1. The latter reacted with different chemical reagents to give thiazole, pyrano[2,3-d]thiazole and thiazolo[ 4,5-d]thiazole derivatives. Cytotoxicity effects of the newly synthesized products against six cancer cell lines, namely, human gastric cancer (NUGC), human colon cancer (DLD- 1), human liver cancer (HA22T and HEPG-2), human breast cancer (MCF) and nasopharyngeal carcinoma (HONE-1) as well as against a normal fibroblast cell (WI-38) were evaluated...
December 20, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29337676/alkyl-polyglucoside-vs-ethoxylated-surfactant-based-microemulsions-as-vehicles-for-two-poorly-water-soluble-drugs-physicochemical-characterization-and-in-vivo-skin-performance
#12
Nataša Z Bubić Pajić, Marija N Todosijević, Gordana M Vuleta, Nebojša D Cekić, Vladimir D Dobričić, Sonja R Vučen, Bojan R Čalija, Milica Ž Lukić, Tanja M Ilić, Snežana D Savić
Two types of biocompatible surfactants were evaluated for their capability to formulate skin-friendly/non-irritant microemulsions as vehicles for two poorly water-soluble model drugs differing in properties and concentrations: alkyl polyglucosides (decyl glucoside and caprylyl/capryl glucoside) and ethoxylated surfactants (glycereth-7-caprylate/ caprate and polysorbate 80). Phase behavior, structural inversion and microemulsion solubilization potential for sertaconazole nitrate and adapalene were found to be highly dependent on the surfactants structure and HLB value...
December 20, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29337675/synthesis-and-evaluation-of-antitumor-activity-of-new-4-substituted-thieno-3-2-d-pyrimidine-and-thienotriazolopyrimidine-derivatives
#13
Hend N Hafez, Abdel-Rhman B A El-Gazzar
3-Methyl-6-phenyl-2-thioxo-2,3-dihydrothieno[3,2-d]pyrimidin- 4(1H)-one (2), on treatment with phosphorous oxychoride, affored 4-chloro-3-methyl-6-phenyl -thieno[3,2-d]pyrimidine- 2(3H)-thione (3). A series of novel 6-phenyl-thieno[3,2-d]pyrimidine derivatives 4-9 bearing different functional groups were synthesized via treatment of compound 3 with different reagents. On the other hand, compound 2 was used to synthesize ethyl-[(3-methyl-6-phenyl-2-thioxo-2,3-dihydrothieno[ 3,2-d]pyrimidin-4-yl)-oxy]acetate (10), 2-hydrazinyl- -3-methyl-6-phenyl-thieno[3,2-d]pyrimidin-4(3H)-one (11), 3-methyl-2-(methyl-sulfanyl)-6-phenyl-thieno[3,2-d]pyrimidin- 4(3H)-one (12) and N-(phenyl)/4-chlorophenyl or methoxy- phenyl)-2-[(3-methyl-4-oxo-6-phenyl-3,4-dihydrothieno[ 3,2-d]pyrimidin-2-yl)-sulfanyl]-acetamide (13a-c)...
December 20, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29337674/a-study-on-blocking-store-operated-ca2-entry-in-pulmonary-arterial-smooth-muscle-cells-with-xyloketals-from-marine-fungi
#14
Jie-Bin Zhou, Ying-Ying Sun, Ying-Lin Zheng, Chu-Qin Yu, Hua-Qing Lin, Ji-Yan Pang
In this study, the effect of four xyloketals 1-4 on store-operated calcium entry (SOCE) was investigated in primary distal pulmonary arterial smooth muscle cells (PASMCs) isolated from mice. The results showed that xyloketal A (1), an unusual ketal with C-3 symmetry, exhibited strong SOCE blocking activity. Secretion of interleukin-8 (IL-8) was also inhibited by xyloketal A. The parallel artificial membrane permeability assay (PAMPA) of 1-4 suggested that these xyloketals penetrated easily through the cell membrane...
December 20, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29337673/evaluation-of-immunomodulatory-effects-of-lamotrigine-in-balb-c-mice
#15
Eman Y Abu-Rish, Shada Y Elhayek, Yehia S Mohamed, Islam Hamad, Yasser Bustanji
Modulation of the immune system has recently been shown to be involved in the pharmacological effects of old antiepileptic drugs and in the pathogenesis of epilepsy. Therefore, the most recent guidelines for immunotoxicological evaluation of drugs were consulted to investigate the immunomodulatory effects of lamotrigine, a newer antiepileptic drug, in BALB/c mice. These included the in vivo effects of lamotrigine on delayed-type hypersensitivity (DTH) response to sheep red blood cell (SRBC) antigens, hemagglutination titer assays and hematological changes...
December 20, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29337672/influence-of-plasma-on-the-physical-properties-of-ointments-with-quercetin
#16
Beata Szulc-Musioł, Barbara Dolińska, Justyna Kołodziejska, Florian Ryszka
Effects of two independent variables - the content of quercetin (0 or 1 or 1.5 or 5 %) and the content of plasma (0 or 2 or 4 or 6 %) - on the organoleptic properties and rheological parameters of model formulations prepared on an amphiphilic base were estimated. The consistency of all ointments was uniform, and the content of quercetin and plasma lay within the predefined range. Tested ointments are non-Newtonian systems. The content of quercetin and plasma was found to have a significant effect on the rheological properties of the ointments...
December 20, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29337671/spectrophotometric-method-for-simultaneous-determination-of-valsartan-and-substances-from-the-group-of-statins-in-binary-mixtures
#17
Mariusz Stolarczyk, Anna Apola, Anna Maślanka, Anna Kwiecień, Włodzimierz Opoka
Applicability of derivative spectrophotometry for the determination of valsartan in the presence of a substance from the group of statins was checked. The obtained results indicate that the proposed method may be effective by using appropriate derivatives: for valsartan and fluvastatin - D1, D2 and D3, for valsartan and pravastatin - D1 and D3, for valsartan and atorvastatin - D2 and D3. The method was characterized by high sensitivity and accuracy. Linearity was maintained in the following ranges: 9.28-32...
December 20, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29337670/sustained-release-biodegradable-solid-lipid-microparticles-formulation-evaluation-and-statistical-optimization-by-response-surface-methodology
#18
Muhammad Hanif, Hafeez Ullah Khan, Samina Afzal, Asif Mahmood, Safirah Maheen, Khurram Afzal, Nabila Iqbal, Mehwish Andleeb, Nazar Abbas
For preparing nebivolol loaded solid lipid microparticles (SLMs) by the solvent evaporation microencapsulation process from carnauba wax and glyceryl monostearate, central composite design was used to study the impact of independent variables on yield (Y1), entrapment efficiency (Y2) and drug release (Y3). SLMs having a 10-40 μm size range, with good rheological behavior and spherical smooth surfaces, were produced. Fourier transform infrared spectroscopy, differential scanning calorimetry and X-ray diffractometry pointed to compatibility between formulation components and the zeta-potential study confirmed better stability due to the presence of negative charge (-20 to -40 mV)...
December 20, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29337669/gastroprotective-effects-of-the-isopropanol-extract-of-artemisia-princeps-and-its-gastroretentive-floating-tablets-on-gastric-mucosal-injury
#19
Joo-Il Kim, Sang-Wook Park, Jhong-Jae Lim, Se-Il Sohn, Ji-Su Shin, Sang Cheol Park, Young Pyo Jang, Eun Kyoung Chung, Hong-Woo Lee, Kyung-Tae Lee
In this study, we investigated the gastroprotective effect of an isopropanol extract from the aerial parts of Artemisia princeps (IPAP) and developed a gastroretentive floating tablet of IPAP (IPAP-FR) for maximized local gastroprotective effects. Pre-treatment with IPAP ameliorated the gastric mucosal hemorrhagic lesions in ethanol/HCl- or indomethacin- treated rats. IPAP decreased mucosal hemorrhage of gastric ulcers induced by ethanol or indomethacin plus pyloric ligation in rats. The optimized floating tablet, IPAP-FR, floated on medium surface with more sustained eupatilin release compared to the non-floating control tablet...
December 20, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29337668/solving-manufacturing-problems-for-l-carnitine-l-tartrate-to-improve-the-likelihood-of-successful-product-scale-up
#20
Aliaa A Badawi, Mahmoud M Hegazy, Dina Louis, Mohammed A Eldegwy
L-carnitine-L-tartrate, a non-essential amino acid, is hygroscopic. This causes a problem in tablet production due to pronounced adhesion of tablets to punches. A 33 full factorial design was adopted to suggest a tablet formulation. Three adsorbents were suggested (Aerosil 200, Aerosil R972, talc) to reduce stickiness at three concentrations (1, 3 and 5 %), and three fillers (mannitol, Avicel PH 101, Dibasic calcium phosphate) were chosen to prepare 27 formulations. Micromeritic properties of formulations were studied, and tablets were prepared by wet granulation...
December 20, 2017: Acta Pharmaceutica
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