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Acta Pharmaceutica

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https://www.readbyqxmd.com/read/29702483/topical-antifungal-bigels-formulation-characterization-and-evaluation
#1
COMPARATIVE STUDY
Agne Mazurkeviciute, Kristina Ramanauskiene, Marija Ivaskiene, Aidas Grigonis, Vitalis Briedis
Bigels with antifungal substances, ciclopirox olamine and terbinafine hydrochloride, were made of hydrogel (poloxamer 407 gel) and oleogel (polyethylene and liquid paraffin mixture). Prepared bigels were found physically stable at room temperature for six months and at least four months at 40 °C. Released amount of drug decreased when oleogel concentration in the formulation increased. Release test results depended on the insertion place of active substances. The amount of released substance was highest when ciclopirox olamine was incorporated in both phases in an equal quantity, and terbinafine hydrochloride in oleogel or in hydrogel...
June 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29702482/development-and-evaluation-of-orally-disintegrating-tablets-containing-the-mosapride-resin-complex
#2
Tong Wu, Guanhua Wang, Caihong Shi, Jinghan Li, Na Zhao, Zihao Dong, Weisan Pan, Xiangrong Zhang
The purpose of this study was to prepare a mosapride citrate-resin (Amberlite® IRP 88) complex and orally fast-disintegrating tablets of the resin complex. The resinate complex of mosapride-Amberlite® IRP 88, mass ratio 2:1, was prepared in an ethanol-water solution. The effects of alcohol concentration, temperature, and pH of the solution on complex formation were evaluated. The complex physicochemical properties were characterized by differential scanning calorimetry, X-ray diffraction and scanning electron microscopy...
June 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29702481/paeoniflorin-inhibits-the-growth-of-bladder-carcinoma-via-deactivation-of-stat3
#3
Jianhui Yang, Yu Ren, Zhong-Guan Lou, Xue Wan, Guo-Bin Weng, Dong Cen
Bladder cancer (BCa) is one of the most common urinary cancers. The present study aims to investigate whether Paeoniflorin (Pae) can exert inhibitory effects on BCa. The results showed that Pae inhibited proliferation of human BCa cell lines in a concentration- and time-dependent manner. Pae and cisplatin (Cis) synergistically inhibited the growth of tumours in RT4-bearing mice. Pae treatment neutralized the body loss induced by Cis. Moreover, Pae induced apoptosis in RT4 cells and increased the activities of caspase3, caspase8 and caspase9...
June 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29702480/spectrofluorimetric-method-for-atenolol-determination-based-on-gold-nanoparticles
#4
Esam Bakir, Mohamed Gouda, Ahmed Alnajjar, Waleed E Boraie
A simple and sensitive spectrofluorimetric method for determination of atenolol (ATE) using gold nanoparticles (AuNPs) was developed. The method is based on the quenching effect of atenolol on photoluminescence of AuNPs at λem = 705 nm. Variables affecting luminescence of gold nanoparticles such as the solvent, pH value and surfactant were studied and optimized. The method was preliminarily validated according to ICH guidelines. A linear correlation was recorded within the range of 1.0-10 mg mL-1 ATE with the coefficient of determination R2 of 0...
June 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29702479/preparation-and-characterization-of-simvastatin-dm%C3%AE-cd-complex-and-its-pharmacokinetics-in-rats
#5
COMPARATIVE STUDY
Fugen Gu, Jia Ning, Huimin Fan, Chunzhi Wu, Yi Wang
Simvastatin is poorly bioavailable because it is practically insoluble in water and shows dissolution rate-limited absorption. Solubilizing effects of several β-cyclodextrin (βCD) derivatives such as HPβCD, SBEβCD and DMβCD on simvastatin in aqueous solution were investigated using the phase solubility technique. The solubility diagram of simvastatin with each βCD derivative could be classified as AL-type, indicating soluble complex formation of 1:1 stoichiometry. Among the above βCD derivatives DMβCD was found to be the ideal complexing agent for improving drug solubility...
June 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29702478/reversed-phase-hplc-for-strontium-ranelate-method-development-and-validation-applying-experimental-design
#6
Béla Kovács, Lajos Kristóf Kántor, Mircea Dumitru Croitoru, Éva Katalin Kelemen, Mona Obreja, Előd Ernő Nagy, Blanka Székely-Szentmiklósi, Árpád Gyéresi
A reverse-phase HPLC (RP-HPLC) method was developed for strontium ranelate using a full factorial, screening experimental design. The analytical procedure was validated according to international guidelines for linearity, selectivity, sensitivity, accuracy and precision. A separate experimental design was used to demonstrate the robustness of the method. Strontium ranelate was eluted at 4.4 minutes and showed no interference with the excipients used in the formulation, at 321 nm. The method is linear in the range of 20-320 μg mL-1 (R2 = 0...
June 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29702477/in-vitro-oxidative-stress-regulatory-potential-of-citrullus-colocynthis-and-tephrosia-apollinea
#7
COMPARATIVE STUDY
Tania Shamim Rizvi, Abdul Latif Khan, Liaqat Ali, Narjis Al-Mawali, Fazal Mabood, Javid Hussain, Muhammad Adnan, Ahmed Al-Harrasi
The present study investigates the potential role of medicinal plants Citrullus colocynthis and Tephrosia apollinea in ameliorating the oxidative stress developed during the generation of reactive oxygen species. Organic extracts of different organs (leaf, stem and root) of these medicinal plants obtained in n-hexane, chloroform, n-butanol and water were assayed for radical scavenging, total antioxidant capacity, anti-lipid peroxidation and reduced glutathione. The total phenolic content (TPC) of both selected medicinal plants was also evaluated...
June 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29702476/effect-of-lemongrass-water-extract-supplementation-on-atherogenic-index-and-antioxidant-status-in-rats
#8
Nuntiya Somparn, Suphaket Saenthaweeuk, Jarinyaporn Naowaboot, Atcharaporn Thaeomor, Veerapol Kukongviriyapan
Cymbopogon citratus (DC) Stapf., commonly known as lemongrass, possesses strong antioxidant and cardiotonic properties. Lemongrass water extract contains several polyphenolic compounds including gallic acid, isoquercetin, quercetin, rutin, catechin and tannic acid. Rutin, isoquercetin catechin and quercetin are the flavonoids most abundantly found in the extract. The extract significantly decreased total cholesterol, low-density lipoprotein and atherogenic index in rats after treatment (p < 0.05). Expression of genes and protein of sterol regulatory element binding protein-1c (SREBP1c) and HMG-CoA reductase (HMGR) was also lowered significantly in treated groups (p < 0...
June 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29702475/tlc-determination-of-some-flavanones-in-the-buds-of-different-genus-populus-species-and-hybrids
#9
COMPARATIVE STUDY
Loretta Pobłocka-Olech, Piotr Migas, Mirosława Krauze-Baranowska
Flavonoids in the buds of eight Populus species and hybrids were detected and compared with the aid of an optimized TLC method. Separation of 17 flavonoid aglycones belonging to different groups, namely, flavones, flavonols, flavanones and flavanonols, previously described as constituents of poplar buds, was performed on silica gel plates using a hexane/ethyl acetate/formic acid (60:40:1.3, V/V/V) mixture as the mobile phase. Pinocembrin and pinostrobin were found in the majority of analyzed poplar buds. For quantitative analysis of both compounds, two TLC evaluation modes, densitometric and videodensitometric, were compared and the established methods were validated...
June 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29702474/hydroxyapatite-ciprofloxacin-delivery-system-synthesis-characterisation-and-antibacterial-activity
#10
Maria-Viorica Ciocilteu, Andreea Gabriela Mocanu, Adriana Mocanu, Catalin Ducu, Oana Elena Nicolaescu, Valentin Costel Manda, Adina Turcu-Stiolica, Claudiu Nicolicescu, Razvan Melinte, Maria Balasoiu, Octavian Croitoru, Johny Neamtu
The main objective of this study was to synthesize hydroxyapatite-ciprofloxacin composites using a chemical precipitation method and to evaluate the properties and in vitro release profile of the drug from the hydroxyapatite-ciprofloxacin composites. Composite characterization was achieved by FT-IR, XRD and DLS. Ciprofloxacin determination was accomplished by HPLC, resulting in good incorporation efficiency of the drug (18.13 %). The in vitro release study (Higuchi model C = K t1/2 and Ritger-Peppas model, C = K t0...
June 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453917/comparative-chemical-investigation-and-evaluation-of-antioxidant-and-tyrosinase-inhibitory-effects-of-withania-somnifera-l-dunal-and-solanum-nigrum-l-berries
#11
Abdul Hameed, Naveed Akhtar
In the present study, berries of two different species of Solanaceae family, Withania somnifera (WS) and Solanum nigrum (SN), were extracted in methanol and then fractionated with solvents, ranging from non-polar to polar, for their phytochemical profiling and investigation of antioxidant and tyrosinase enzyme inhibition capacity. The methanolic extract and n-hexane, ethyl acetate (WSEA, SNEA) and aqueous fractions were chemically analyzed and evaluated for biological activity. Total flavonoids and total phenolics were quantified in WSEA (96...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453916/distinguishing-smilax-glabra-and-smilax-china-rhizomes-by-flow-injection-mass-spectrometry-combined-with-principal-component-analysis
#12
Jian Liang, Meng Zhou, Lin-Yu Li, Ji-Cheng Shu, Yong-Hong Liang, Feng-Qin Li, Li Xiong, Hui-Lian Huang
Flow-injection mass spectrometry (FIMS) coupled with a chemometric method is proposed in this study to profile and distinguish between rhizomes of Smilax glabra (S. glabra) and Smilax china (S. china). The proposed method employed an electrospray-time-of-flight MS. The MS fingerprints were analyzed using principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) with the aid of SIMCA software. Findings showed that the two kinds of samples perfectly fell into their own classes...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453915/efficacy-of-nucleoside-analogues-for-hepatitis-b-virus-related-liver-failure-a-network-meta-analysis
#13
REVIEW
Jian Wu, Fang Yin, Xinmin Zhou
The purpose of this study was to compare the efficacy of nucleoside analogues (NAs) in the treatment of HBV-related liver failure. The data of patients with HBV-related liver failure treated with nucleoside analogues were used to conduct a network meta-analysis. A total of 1660 patients from 12 articles about the efficacy of lamivudine, entecavir, telbivudine and tenofovir for HBV-related liver failure treatment were recruited in the study. The highest two- and three-month survival rate was recorded for patients using tenofovir...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453914/medication-adherence-and-health-related-quality-of-life-among-patients-with-chronic-obstructive-pulmonary-disease
#14
Nejc Horvat, Igor Locatelli, Mitja Kos, Ana Janežič
This study evaluated medication adherence and health-related quality of life (HRQoL) of Slovenian patients with chronic obstructive pulmonary disease (COPD) and examined the factors associated with HRQoL. Demographic and therapy information was collected from 65 patients through interviews. The St. George's Respiratory Questionnaire and the Morisky Medication Adherence Scale were used to evaluate HRQoL and adherence, resp. A multiple linear regression model was used to assess the association between the factors and HRQoL...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453913/chronic-fluoxetine-treatment-induces-lipid-accumulation-but-does-not-alter-the-expression-of-pref-1-in-rat-adipose-tissue
#15
László-István Bába, Zsolt Gáll, István Lóránt Bíró, Tibor Mezei, Imre Zoltán Kun, Melinda Kolcsár
This study aims to investigate the effects of chronic fluoxetine (FLX) treatment on preadipocyte factor-1 (Pref-1) expression in subcutaneous, visceral and brown adipose tissues, and on the size of vacuoles in a dipocytes obtained from the perirenal regions in rats. Twenty-eight Wistar rats were treated with FLX at two different doses and fourteen animals received vehicle. After 40 days of treatment, the subcutaneous, perirenal and interscapular adipose tissues were collected. Pref-1 expression was examined using an immunohistochemical method and the vacuolar area was measured in stained sections...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453912/hptlc-determination-of-diosgenin-in-fenugreek-seeds
#16
Barbara Król-Kogus, Khenifi Mohammed Lamine, Piotr Migas, Messaoud Boudjeniba, Mirosława Krauze-Baranowska
A new HPTLC-densitometric method for diosgenin determination in fenugreek seeds was established after optimization of the conditions for efficient saponin extraction and acid hydrolysis. Several procedures were tested, the best of which was a three-step Soxhlet extraction, followed by hydrolysis of the obtained methanolic extract with 2 mol L-1 H2SO4. Best diosgenin separation from other hydrolysis products was obtained on HPTLC Si60F254 plates u sing a mixture of n-heptane/ethyl acetate (7:3, V/V) and modified anisaldehyde as a spraying reagent...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453911/induction-of-xenobiotic-metabolizing-enzymes-in-hepatocytes-by-beta-naphthoflavone-time-dependent-changes-in-activities-protein-and-mrna-levels
#17
Kateřina Lněničková, Lenka Skálová, Lucie Stuchlíková, Barbora Szotáková, Petra Matoušková
In the present study, time-dependency of the induction effect of a selective inducer on the activity, protein and mRNA levels of cytochromes P450 1A1/2 (CYP1A1/2), NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione S-transferases (GSTA), in primary culture of rat hepatocytes was tested and evaluated. To show the differences in responses of tested enzymes, the common aryl hydrocarbon receptor (AhR) ligand agonist, beta-naphthoflavone (BNF), was used. Induction of CYP1A1/2 by BNF was detected at all time intervals and at all levels (i...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453910/advanced-spectrophotometric-chemometric-methods-for-resolving-the-binary-mixture-of-doxylamine-succinate-and-pyridoxine-hydrochloride
#18
Plamen Katsarov, Georgi Gergov, Aylin Alin, Bissera Pilicheva, Yahya Al-Degs, Vasil Simeonov, Margarita Kassarova
The prediction power of partial least squares (PLS) and multivariate curve resolution-alternating least squares (MCR-ALS) methods have been studied for simultaneous quantitative analysis of the binary drug combination - doxylamine succinate and pyridoxine hydrochloride. Analysis of first-order UV overlapped spectra was performed using different PLS models - classical PLS1 and PLS2 as well as partial robust M-regression (PRM). These linear models were compared to MCR-ALS with equality and correlation constraints (MCR-ALS-CC)...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453909/a-headspace-gas-chromatography-method-for-isopropanol-determination-in-warfarin-sodium-products-as-a-measure-of-drug-crystallinity
#19
Ziyaur Rahman, Sohail Akhtar, Akhtar Siddiqui, Anthony B Ciavarella, Agnes Nguyenpho, Patrick J Faustino, Mansoor A Khan
Coumadin® a nd s everal generic products of warfarin s odium (WS) contain the crystalline form (clathrate) in which WS and isopropanol (IPA) are associated in a 2:1 molar ratio. IPA is critical in maintaining the WS crystalline structure. Physicochemical properties of the drug and drug product may change when the crystalline drug transforms to amorphous form. A headspace-gas chromatography (HS-GC) method was developed and validated for IPA determination in the WS drug product. n-propanol (NPA) was used as internal standard and the method was validated for specificity, system suitability, linearity, accuracy, precision, range, limits of detection and quantification, and robustness...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453908/effective-anti-adhesives-of-uropathogenic-escherichia-coli
#20
REVIEW
Rosana Ribić, Tomislav Meštrović, Marijana Neuberg, Goran Kozina
Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are among the most common infectious diseases in humans. Due to their frequent occurrence in the community and nosocomial settings, as well as the development of resistance to the commonly prescribed antimicrobial agents, an enormous financial burden is placed on healthcare systems around the world. Therefore, novel approaches to the prevention and treatment of UTIs are needed. Although UPEC may harbour a plethora of virulence factors, type I fimbriae and P pili are two of the most studied adhesive organelles, since the attachment to host cells in the urinary tract is a crucial step towards infection...
March 1, 2018: Acta Pharmaceutica
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