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European Spine Journal

Ming-Bo Guo, De-Chun Wang, Hai-Fei Liu, Long-Wei Chen, Jian-Wei Wei, Yong Lin, Hui Xue
PURPOSE: This study aimed to investigate the potential mechanism and value of lupeol in inhibiting high-glucose-induced apoptosis in rabbit nucleus pulposus cells (NPCs). METHODS: NPCs were divided into four groups: control (CON), high glucose (HG), LUP, and HG + LUP. Viability, reactive oxygen species (ROS) levels, and apoptosis were examined in NPCs. The protein expression levels of Bax, Bcl-2, cytochrome C, and caspase 9/3 were measured using reverse transcription-polymerase chain reaction and Western blot assay...
July 14, 2018: European Spine Journal
Max Aebi
No abstract text is available yet for this article.
July 14, 2018: European Spine Journal
Karsten Wiechert
No abstract text is available yet for this article.
July 14, 2018: European Spine Journal
Christoph J Siepe, Daniel Sauer, H Michael Mayer
No abstract text is available yet for this article.
July 14, 2018: European Spine Journal
Cesare Faldini, Alberto Ruffilli, Fabrizio Perna, Federico Pilla, Alessandro Panciera, Francesco Traina
No abstract text is available yet for this article.
July 14, 2018: European Spine Journal
Jia Liu, Shengfa Li, Ke Huang, Xianzhe Lu, Yu Shi, Kegong Xie, Yujing Tang
PURPOSE: Disorders of the upper thoracic spine can lead to serious disability and morbidity. However, operating on the upper thoracic vertebrae T2-T5 remains challenging because of the anatomical features of the thoracic spine. We describe a novel anterolateral upper thoracic approach, which is safe and reproducible and allows direct access to the upper thoracic spine from T2 to T6 inclusive, obviating the risk of damaging complex anatomical structures inherent in the anterior trans-sternal approach...
July 13, 2018: European Spine Journal
Julio Urrutia, Pablo Besa, Sergio Morales, Antonio Parlange, Sebastian Flores, Mauricio Campos, Sebastian Mobarec
PURPOSE: Differentiating osteoporotic vertebral fractures (OVF) from metastatic vertebral fractures (MVF) is difficult. A magnetic resonance imaging (MRI)-based score (META score) aiming to differentiate OVF and MVF was recently published; however, an independent agreement assessment is required before the score is used. We performed such independent agreement evaluation, including raters with different levels of training. METHODS: Sixty-four patients with confirmed OVF or MVF were evaluated by six raters (three spine surgeons and three orthopaedic residents) using the META score...
July 11, 2018: European Spine Journal
Niek Koenders, Alison Rushton, Martin L Verra, Paul C Willems, Thomas J Hoogeboom, J Bart Staal
PURPOSE: Lumbar spinal fusion (LSF) is frequently and increasingly used in lumbar degenerative disorders despite conflicting results and recommendations. A thorough understanding of patient outcomes after LSF is required to inform decisions regarding surgery and to improve post-surgery management. The current study aims to evaluate the course of pain and disability in patients with degenerative disorders of the lumbar spine after first-time LSF. METHODS: A systematic review and meta-analysis of pain and disability outcomes in prospective cohort studies up to 31 March 2017 is identified in four electronic databases...
July 11, 2018: European Spine Journal
Ganesha K Thayaparan, Mark G Owbridge, Robert G Thompson, Paul S D'Urso
PURPOSE: Despite the variety of "off-the-shelf" implants and instrumentation, outcomes following revision lumbosacral surgery are inconstant. Revision fusion surgery presents a unique set of patient-specific challenges that may not be adequately addressed using universal kits. This study aims to describe how patient-specific factors, surgeon requirements, and healthcare efficiencies were integrated to design and manufacture anatomically matched surgical tools and implants to complement a minimally invasive posterior approach for revision lumbar fusion surgery...
July 10, 2018: European Spine Journal
Osamu Tono, Kazuhiro Hasegawa, Masashi Okamoto, Shun Hatsushikano, Haruka Shimoda, Kei Watanabe, Katsumi Harimaya
PURPOSE: To test the hypothesis that the relationship between PI and L1-S1 lumbar lordosis (LL) is always positive, even in cases with different lumbar sagittal profiles. METHODS: Standing whole-spine sagittal alignment was measured with EOS system in 100 healthy adults (46 men, 54 women, mean age 40.9 years). The apex of lumbar lordosis was defined as the most anterior lumbar vertebra or intervertebral disk from the gravity line determined by a force plate measurement...
July 10, 2018: European Spine Journal
Cesare Faldini, Fabrizio Perna, Antonio Mazzotti, Niccolò Stefanini, Giuseppe Geraci, Francesco Traina
No abstract text is available yet for this article.
July 9, 2018: European Spine Journal
Christoph J Siepe, Daniel Sauer
No abstract text is available yet for this article.
July 9, 2018: European Spine Journal
Ming Lu, Zhongxin Zhou, Zixiong Lei, Haomiao Li, Stefano Boriani
PURPOSE: En bloc resection is the treatment of choice of myxoid chondrosarcoma. These tumors can produce huge masses. Anatomical constraints limit the possibility to perform en bloc resection in the spine. METHODS: A very huge myxoid chondrosarcoma (14.2 × 10.8 × 11.4 cm) arising from T2 to T5 and invading the whole higher left pleural cavity was observed. Surgical planning according to WBB staging system was performed. RESULTS: The tumor was successfully submitted to en bloc resection achieving a tumor-free margin as demonstrated by the pathologist's report...
July 4, 2018: European Spine Journal
(no author information available yet)
No abstract text is available yet for this article.
July 3, 2018: European Spine Journal
Crystian B Oliveira, Chris G Maher, Rafael Z Pinto, Adrian C Traeger, Chung-Wei Christine Lin, Jean-François Chenot, Maurits van Tulder, Bart W Koes
OBJECTIVE: The aim of this study was to provide an overview of the recommendations regarding the diagnosis and treatment contained in current clinical practice guidelines for patients with non-specific low back pain in primary care. We also aimed to examine how recommendations have changed since our last overview in 2010. METHOD: The searches for clinical practice guidelines were performed for the period from 2008 to 2017 in electronic databases. Guidelines including information regarding either the diagnosis or treatment of non-specific low back pain, and targeted at a multidisciplinary audience in the primary care setting, were considered eligible...
July 3, 2018: European Spine Journal
Alfredo Franco-Obregón, Elena Cambria, Helen Greutert, Timon Wernas, Wolfgang Hitzl, Marcel Egli, Miho Sekiguchi, Norbert Boos, Oliver Hausmann, Stephen J Ferguson, Hiroshi Kobayashi, Karin Wuertz-Kozak
PURPOSE: Prolonged bed rest and microgravity in space cause intervertebral disc (IVD) degeneration. However, the underlying molecular mechanisms are not completely understood. Transient receptor potential canonical (TRPC) channels are implicated in mechanosensing of several tissues, but are poorly explored in IVDs. METHODS: Primary human IVD cells from surgical biopsies composed of both annulus fibrosus and nucleus pulposus (passage 1-2) were exposed to simulated microgravity and to the TRPC channel inhibitor SKF-96365 (SKF) for up to 5 days...
July 2, 2018: European Spine Journal
Po-Hsun Tu, Chun-Ting Chen, Ching-Chang Chen, Jyi-Feng Chen, Chieh-Tsai Wu, Kuo-Chen Wei, Zhuo-Hao Liu
PURPOSE: Cervical laminectomy is an effective treatment for multilevel cervical compressive myelopathy. Symptomatic spinal cord compression (SSCC) by paraspinal musculature (PSM) following cervical laminectomy is rarely reported. The aim of this study was to evaluate the frequency and pathogenesis of this complication after cervical laminectomy. METHODS: Between 2007 and 2016, the medical records of 1309 cervical laminectomy patients were reviewed. From these 1309 records, seven patients (five men and two women; average age, 64...
July 2, 2018: European Spine Journal
Mark Nowell, Richard Nelson
PURPOSE: Traumatic atlantoaxial dislocation (AAD) is usually associated with fatal high-velocity road traffic accidents (Xu et al. in Medicine (Baltimore) 94:e1768, 2015). There are few reports of survival following posterior AAD without odontoid fracture (Xu et al. 2015; Zhen et al. in Arch Orthop Trauma Surg 131:681-685, 2011; de Carvalho and Swash in Handb Clin Neurol 119:435-448, 2014). METHOD: We present a previously undescribed case of posterior AAD associated with a C1 Jefferson fracture but no odontoid fracture and bilateral vertebral artery occlusion without neurological deficit...
July 2, 2018: European Spine Journal
Haining Tan, Jianxiong Shen, Fan Feng, Jianguo Zhang, Hai Wang, Chong Chen, Zheng Li
PURPOSE: To clarify the clinical manifestation and radiological characteristics of idiopathic syringomyelia (IS) and to investigate the relationship between syrinx and scoliotic curves in IS-related scoliosis patients. METHODS: Fifty-five patients with IS and scoliosis were identified and reviewed retrospectively from June 2009 to December 2016. Radiographic features of syrinx, scoliosis and clinical manifestations of neurological deficits were collected. The syrinx/cord (S/C) ratio was defined as the anteroposterior diameter of syrinx divided by the diameter of spinal cord at the same level...
June 30, 2018: European Spine Journal
Emmanuelle Ferrero, Nicolas Bocahut, Yan Lefevre, Pierre Roussouly, Sebastien Pesenti, Walid Lakhal, Thierry Odent, Christian Morin, Jean-Luc Clement, Roxane Compagnon, Jérôme Sales de Gauzy, Jean-Luc Jouve, Keyvan Mazda, Kariman Abelin-Genevois, Brice Ilharreborde
INTRODUCTION: Proximal junctional kyphosis (PJK) is a frequent complication, up to 46%, in adolescent idiopathic scoliosis surgical treatment (AIS). Several risk factors have been evoked but remain controversial. The purpose of this study was to analyze the incidence of PJK in a multicenter cohort of AIS patient and to determine risk factor for PJK. MATERIALS AND METHODS: Lenke I and II AIS patients operated between 2011 and 2015 (minimum of 2-years follow-up) were included...
June 29, 2018: European Spine Journal
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