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European Journal of Cancer Care

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https://www.readbyqxmd.com/read/28707433/comparison-of-irinotecan-platinum-versus-etoposide-platinum-chemotherapy-for-extensive-stage-small-cell-lung-cancer-a-meta-analysis
#1
D Han, G Wang, L Sun, X Ren, W Shang, L Xu, S Li
This meta-analysis was performed to compare the effects and toxicities between irinotecan/platinum (IP) and etoposide/platinum (EP) regimens as the fist-line treatment of patients with extensive-stage small cell lung cancer (E-SCLC). A systematic search was made of MEDLINE, Cochrane, ISI Web of Science and SCOPUS databases. Randomised clinical trials on treatment of E-SCLC with the IP regimens, compared with EP regimens, were reviewed. Studies were pooled to hazard ratio (HR), relative risk (RR) and odds ratio (OR), with 95% confidence interval (CI)...
July 13, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28707369/psychological-stress-affects-the-severity-of-radiation-induced-acute-skin-reactions-in-breast-cancer-patients
#2
A E Sutherland, N C Bennett, P M Herst
Psychological stress exacerbates many pathological conditions including inflammatory skin conditions. The effect of psychological stress on acute radiation-induced skin reactions has not been documented before. Here, we aimed to explore if psychological stress could aggravate skin reaction severity in breast cancer patients. We conducted a secondary analysis of patient data obtained during a randomised, controlled clinical trial for acute radiation-induced skin reaction severity in 78 breast cancer patients...
July 13, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28675545/cost-effectiveness-analysis-of-fulvestrant-versus-anastrozole-as-first-line-treatment-for-hormone-receptor-positive-advanced-breast-cancer
#3
H Ding, L Fang, W Xin, Y Tong, Q Zhou, P Huang
Although recent studies demonstrated that fulvestrant is superior to anastrozole as first-line treatment for hormone receptor (HR)-positive advanced breast cancer, the cost-effectiveness of fulvestrant versus anastrozole remained uncertain. Thus, the current study aimed to evaluate the cost-effectiveness of fulvestrant compared with anastrozole in the first-line setting. A Markov model consisting of three health states (stable, progressive and dead) was constructed to simulate a hypothetical cohort of patients with HR-positive advanced breast cancer...
July 3, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28671297/standardisation-of-minimal-residual-disease-in-multiple-myeloma
#4
V Innao, A Allegra, S Russo, D Gerace, D Vaddinelli, A Alonci, A G Allegra, C Musolino
The assessment of the effectiveness of chemotherapy in oncology cannot disregard the concept of minimal residual disease (MRD). In fact, the efforts of numerous scientific groups all over the world are currently focusing on this issue, with the sole purpose of defining sensitive, effective assessment criteria that are, above all, able to give acceptable, easily repeatable results worldwide. Regarding this issue, especially with the advent of new drugs, multiple myeloma is one of the haematologic malignancies for which a consensus has not yet been reached...
July 3, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28653449/the-value-of-biomarkers-in-bone-metastasis
#5
Stella D'Oronzo, Janet Brown, Robert Coleman
The worst complication of cancer is represented by its spread to distant sites. In particular, bone provides a fertile soil for several cancer types, especially those derived from breast, prostate and lung tumours. Despite the progress in diagnostic and therapeutic strategies, bone metastases (BM) still impact on quality of life and overall survival, making it necessary to identify the "high-risk" patients at an earlier stage. Since BM affect physiological bone turnover, measurement of bone turnover markers (BTM) has been widely investigated for diagnostic and prognostic purposes, as well as to support the development of anti-cancer drugs...
June 27, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28639355/how-do-the-characteristics-of-breast-cancer-diagnostic-assessment-programmes-influence-service-delivery-a-mixed-methods-study
#6
A R Gagliardi, G Honein-AbouHaidar, T Stuart-McEwan, J Smylie, A Arnaout, J Seely, F C Wright, M J Dobrow, M C Brouwers, K Bukhanov, D R McCready
Diagnostic assessment programmes (DAPs) coordinate multidisciplinary teamwork (MDT), and improve wait times and patient satisfaction. No research has established optimal DAP design. This study explored how DAP characteristics influence service delivery. A mixed methods case study of four breast cancer DAPs was conducted including qualitative interviews with health-care providers and retrospective chart review. Data were integrated using multiple approaches. Twenty-three providers were interviewed; 411 medical records were reviewed...
June 21, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28631284/the-role-of-radiotherapy-in-bone-metastases-a-critical-review-of-current-literature
#7
REVIEW
A Kougioumtzopoulou, A Zygogianni, Z Liakouli, E Kypraiou, V Kouloulias
Radiotherapy is considered the treatment of choice for painful bone metastases. However, novel modalities of radiotherapy have emerged in the concept of oligometastasic disease. In addition, the increase of overall survival of patients with bone metastatic disease in the last decades due to systemic treatments has issued the silent topic of re-irradiation. The aim of this manuscript was to present a current thorough search of relevant literature. Originally, 6,087 articles revealed from PubMed database related to radiotherapy and bone metastases...
June 20, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28597947/the-feasibility-of-a-pragmatic-distance-based-intervention-to-increase-physical-activity-in-lung-cancer-survivors
#8
C J Peddle-McIntye, M K Baker, Y C G Lee, D A Galvão, P Cormie, V Graham, R U Newton
The purpose of this study was to investigate the feasibility and preliminary efficacy of a pragmatic distance-based intervention designed to increase physical activity (PA) participation in lung cancer survivors. Fourteen lung cancer survivors were recruited via invitation from the State Cancer Registry to join a 12-week PA intervention of print materials paired with brief telephone follow-up. Outcome measures of feasibility, PA participation and quality of life (QoL) were assessed at baseline, post-intervention and follow-up via telephone interview...
June 9, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28597493/seeking-accepting-and-declining-help-for-emotional-distress-in-cancer-a-systematic-review-and-thematic-synthesis-of-qualitative-evidence
#9
C M Carolan, A Smith, G R Davies, L Forbat
Many individuals affected by cancer who experience emotional distress report not wanting help. This review aims to understand why individuals affected by cancer seek, accept or decline help for emotional distress and what influences these actions. A systematic review and thematic synthesis of the qualitative literature was conducted. Using pre-defined search terms, four electronic databases were searched from January 2000 to May 2016. Pre-determined inclusion and exclusion criteria were then applied. Identified papers were quality appraised...
June 8, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28557060/epidermal-growth-factor-receptor-and-anaplastic-lymphoma-kinase-testing-and-mutation-prevalence-in-patients-with-advanced-non-small-cell-lung-cancer-in-switzerland-a-comprehensive-evaluation-of-real-world-practices
#10
S M Ess, C Herrmann, H Frick, M Krapf, T Cerny, W Jochum, M Früh
In order to improve outcomes, identification of the epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) genes has become crucial in advanced non-small-cell lung cancer (NSCLC). The aim of the present study is to analyse time trends and frequency of testing, factors affecting testing as well as prevalence of mutations in the Swiss population. We analysed EGFR and ALK testing in a cohort of patients with newly diagnosed metastasised non-squamous NSCLC in the catchment area of the cancer registry Eastern Switzerland in the years 2008-2014...
May 30, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28544085/e-tc-development-and-pilot-testing-of-a-web-based-intervention-to-reduce-anxiety-and-depression-in-survivors-of-testicular-cancer
#11
L E Heiniger, A B Smith, I Olver, P Grimison, B Klein, A Wootten, J-A M Abbott, M A Price, M McJannett, B Tran, M R Stockler, H Gurney, P N Butow
e-TC is an online intervention designed to address common psychosocial concerns of testicular cancer survivors. It aims to reduce anxiety, depression and fear of cancer recurrence by providing evidence-based information and psychological intervention. This paper details the development and pilot testing of e-TC. During pilot testing, 25 men (with varying psychological profiles) who had completed treatment for testicular cancer, 6 months to 5 years ago (which had not recurred), used e-TC over a 10-week period and provided quantitative and qualitative feedback on the feasibility and acceptability of the programme...
May 22, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28523723/patient-characteristics-and-surgery-related-factors-associated-with-patient-reported-recovery-at-1-and-6%C3%A2-months-after-colorectal-cancer-surgery
#12
J Jakobsson, E Idvall, C Kumlien
Predictors for postoperative recovery after colorectal cancer surgery are usually investigated in relation to length of stay (LoS), readmission, or 30-day morbidity. This study describes patient characteristics and surgery-related factors associated with patient-reported recovery 1 and 6 months after surgery. In total, 153 consecutively included patients who were recovering from colorectal cancer surgery reported their level of recovery using the Postoperative Recovery Profile. Multiple logistic regression analysis was used to calculate associations with recovery, defined as good or poor, divided into five recovery dimensions: physical symptoms, physical functions, psychological, social and activity...
May 19, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28513056/lessons-learned-from-a-pilot-study-of-an-indigenous-patient-navigator-intervention-in-queensland-australia
#13
C M Bernardes, J Martin, P Cole, T Kitchener, G Cowburn, G Garvey, E Walpole, P C Valery
Indigenous patient navigator (IPN) programmes show promise in addressing barriers to cancer care and facilitation of patient self-efficacy. The purpose of this paper is to describe and reflect upon the experience of training an IPN and implementation of the intervention in the Australian context with Indigenous cancer patients. Randomised clinical trial might provide the best available evaluation measure of an intervention but caution should be taken in the implementation process. Socio-cultural aspects and training can affect the conduct of this type of intervention...
May 17, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28497549/a-large-scale-prospective-clinical-and-psychometric-validation-of-the-eortc-colorectal-qlq-cr29-module-in-polish-patients-with-colorectal-cancer
#14
B Sanna, K Bereza, D Paradowska, E Kucharska, I M Tomaszewska, Z Dudkiewicz, J Golec, A Bottomley, K A Tomaszewski
The purpose of our study was to assess if the Polish translation of the European Organisation for Research and Treatment of Cancer (EORTC) Colorectal Cancer (CRC)-Specific Quality of Life Questionnaire (QLQ-CR29) is an acceptable and psychometrically valid measure to collect quality of life (QoL) data in Polish patients with CRC for use in clinical trials and clinical practice. A total of 150 patients undergoing treatment for CRC were prospectively enrolled in the study. Psychometric assessment of the translated QLQ-CR29 structure, reliability, convergent and divergent validity, and clinical validity was subsequently performed...
May 11, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28488812/decreased-body-mass-index-is-associated-with-impaired-survival-in-lung-cancer-patients-with-brain-metastases-a-retrospective-analysis-of-624-patients
#15
E K Masel, A S Berghoff, L M Füreder, P Heicappell, F Schlieter, G Widhalm, B Gatterbauer, U Dieckmann, P Birner, R Bartsch, S Schur, H H Watzke, C C Zielinski, M Preusser
Body mass index (BMI) is a prognostic factor in several cancer types. We investigated the prognostic role of BMI in a large patient cohort with newly diagnosed lung cancer brain metastases (BM) between 1990 and 2013. BMI at diagnosis of BM and graded prognostic assessment (GPA) were calculated. Definitions were underweight (BMI <18.50), weight within normal range (BMI 18.50-24.99) and overweight (BMI ≥ 25.00). A total of 624 patients (men 401/624 [64.3%]; women 223/624 [35.7%]; median age of 61 [range 33-88]) were analysed...
May 10, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28488375/factors-associated-with-healthcare-professional-s-rating-of-disfigurement-and-self-perceived-body-image-in-female-patients-with-head-and-neck-cancer
#16
S-C Chen, C-Y Huang, B-S Huang, C-Y Lin, K-H Fan, J T-C Chang, S-C Wu, Y-H Lai
The purpose of this study was to determine factors associated with self-perceived body image in female patients with head and neck cancer (HNC), and factors associated with healthcare professional's rating of disfigurement, as well as the correlation between patient and observer ratings. This cross-sectional study recruited 105 women with HNC at a large medical centre. Measures of facial disfigurement and body image, as well as demographic and clinical characteristics, were collected. Multivariate multiple linear regression modelling was used to identify factors associated with healthcare professional's rating of disfigurement and patient self-perceived body image...
May 9, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28474488/a-q-methodology-study-to-investigate-the-experiences-of-head-and-neck-cancer-patients-from-diagnosis-to-1%C3%A2-year
#17
K J Reid, A Swift, H Mehanna
The experiences of disease and treatment for patients diagnosed with head and neck cancer (H&NC) are known to be important indicators of the quality of care but are represented poorly in the literature. Survival is a major outcome measure to which health-related quality of life (HRQoL) adds detail but outcomes are not fully representative of the patients' experiences because quality of care and reality of treatment are overlooked. This study explored the HRQoL, quality of care and reality of treatment themes using a mixed-methods approach, Q Methodology...
May 4, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28474341/effects-of-preoperative-dexamethasone-on-postoperative-pain-nausea-vomiting-and-respiratory-function-in-women-undergoing-conservative-breast-surgery-for-cancer-results-of-a%C3%A2-controlled-clinical-trial
#18
A O Cortés-Flores, J Jiménez-Tornero, G Morgan-Villela, M Delgado-Gómez, C J Zuloaga-Fernández Del Valle, J García-Rentería, J Rendón-Félix, C Fuentes-Orozco, M D Macías-Amezcua, G Ambriz-González, A S Alvarez-Villaseñor, D Urias-Valdez, M Chavez-Tostado, G I Contreras-Hernández, A González-Ojeda
The objective was to evaluate whether preoperative administration of dexamethasone improved postoperative nausea and vomiting (PONV), pain and respiratory function tests in women undergoing conservative surgery for breast cancer. This was a controlled clinical trial conducted between June 2013 and October 2014. Eighty patients were evaluated. Patients received a preoperative dose of 8 mg of dexamethasone (n = 40) or placebo (n = 40). The data on PONV and pain intensity was obtained and forced spirometry tests were performed, 1 hr before and at 1, 6, 12 and 24 hr after surgery...
May 4, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28440587/risk-benefit-perception-of-pregnancy-among-breast-cancer-survivors
#19
P-L Hsieh, S-M Huang, L-Y Chien, C-F Lee, Y Hsiung, C-J Tai
Helping breast cancer patients who desire a pregnancy after cancer treatment is a vital issue. Little is known about the complex context of the decision to become pregnant after breast cancer treatment. The purpose of this study was to understand the risk-benefit perception of choosing conception or contraception after treatment in Taiwan. We applied grounded theory to guide this exploratory qualitative study. Data were collected through in-depth interviews with 16 breast cancer patients. Pregnancy was addressed in the context of cancer as a potentially life-threatening diagnosis and its treatment...
April 25, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28440572/feasibility-of-a-multidisciplinary-intervention-to-help-cancer-patients-return-to-work
#20
M C J Leensen, I F Groeneveld, T Rejda, P Groenenboom, S van Berkel, T Brandon, A G E M de Boer, M H W Frings-Dresen
This study evaluates feasibility of a multidisciplinary intervention combining occupational counselling with physical exercise to enhance cancer patients' return to work, assesses whether care providers and patients were satisfied with the intervention, and describes barriers to and facilitators of execution. Newly diagnosed cancer patients, treated with chemotherapy and on sick leave from (self-)employment participated. Patients received counselling from an oncological occupational physician (OOP), were assessed by a sports physician, and performed a 12-week training programme supervised by physiotherapists...
April 25, 2017: European Journal of Cancer Care
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