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Experimental Dermatology

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https://www.readbyqxmd.com/read/28787094/mast-cells-are-critical-for-the-limitation-of-thrombin-induced-skin-inflammation
#1
Cathleen A Suender, Mandy Leist, Magnus Åbrink, Patricia Valentin, Astrid Geldmacher, Martin Steinhoff, Martin Metz, Marcus Maurer
Thrombin, a key player in coagulation, is widely held to induce and promote inflammation. As of now, the features, kinetics, and control of thrombin's proinflammatory effects on the skin remain to be characterized in detail. We, therefore, injected thrombin into the ear skin of mice and observed strong, dose-dependent, and transient ear swelling responses as well as mast cell degranulation. Unexpectedly, thrombin induced even stronger, not reduced, ear swelling in mast cell-deficient Kit(W-sh/W-sh) mice. Prior local reconstitution of Kit(W-sh/W-sh) mice with mast cells inhibited this effect, indicating that mast cells may contribute to the control of thrombin-induced skin inflammation...
August 8, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28771827/glucocorticoids-the-mode-of-action-in-bullous-pemphigoid
#2
REVIEW
Minna E Kubin, Lars Hellberg, Riitta Palatsi
Bullous pemphigoid (BP) is the most common of pemphigoid diseases caused by autoantibodies against the structures of dermoepidermal junction followed by complement activation, innate immune cell infiltration, neutrophil proteinase secretion and subepidermal blister formation. The first line treatment of BP is topical and systemic glucocorticoids (GC). Regulation of the immune system and inflammatory cells is the main target of GC actions. GCs act through genomic and non-genomic mechanisms. The human glucocorticoid receptor (GR) mediates most of the biologic effects of glucocorticoids: cytosolic GR binds GCs and is capable to bind to glucocorticoid response elements in DNA and either transactivate or transrepress genes depending on the tissue and cell-type...
August 3, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28767174/inactivation-of-beclin-1-dependent-autophagy-promotes-ursolic-acid-induced-apoptosis-in-hypertrophic-scar-fibroblasts
#3
Chuan Cao, Wenping Wang, Lele Lu, Liang Wang, XiaoSong Chen, Rui Guo, Shirong Li, Junzi Jiang
A hypertrophic scar (HS) is caused by abnormal proliferation of dermal fibroblasts. Thus, promoting hypertrophic scar fibroblast (HSFB) apoptosis is an effective strategy for HS therapy. Ursolic acid (UA) has been widely used as an inducer of apoptosis in diverse cancers. However, whether UA plays an inhibitory role in HS formation is still unknown. In our study, UA was used to treat HSFBs and the cell viability, apoptosis, and collagen synthesis were determined by a Cell Counting Kit 8 (CCK8) assay, flow cytometry, and an H(3) -proline incorporation assay, respectively...
August 2, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28767170/what-about-physical-contacts-between-epidermal-keratinocytes-and-sensory-neurons
#4
Matthieu Talagas, Nicolas Lebonvallet, Raphael Leschiera, Pascale Marcorelles, Laurent Misery
Recent studies have demonstrated that keratinocytes closely participate in sensory transduction, and therefore, intra-epidermal free nerve endings are not exclusive transducers of pain. This discovery implies the existence of close afferent communication from keratinocytes to sensory neurons. Although reciprocal interactions between keratinocytes and intra-epidermal free nerve endings via soluble mediators are well established, little attention has been paid to physical contacts between keratinocytes and intra-epidermal free nerve endings...
August 2, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28677275/ultraviolet-radiation-and-skin-mast-cells-effects-mechanisms-and-relevance-for-skin-diseases
#5
REVIEW
Hanna Siiskonen, Anna Smorodchenko, Karoline Krause, Marcus Maurer
Mast cells (MCs) are well-known as versatile effector cells in allergic reactions and several other immune responses. Skin MCs and cutaneous MC responses are subject to the effects of environmental factors including ultraviolet radiation (UVR). Numerous studies have assessed the effects of UVR on MCs, in vitro and in vivo. Interestingly, UVR seems to have variable effects on nonactivated and activated mast cells. In general, UV therapy is beneficial in the treatment of urticaria and mastocytosis, but the effects are variable depending on treatment regimen and type of UVR...
July 4, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28677217/age-associated-intracellular-superoxide-dismutase-deficiency-potentiates-dermal-fibroblast-dysfunction-during-wound-healing
#6
Toshihiro Fujiwara, Teruyuki Dohi, Zeshaan N Maan, Kristine C Rustad, Sun Hyung Kwon, Jagannath Padmanabhan, Alexander J Whittam, Hirotaka Suga, Dominik Duscher, Melanie Rodrigues, Geoffrey C Gurtner
Reactive oxygen species (ROS) impair wound healing through destructive oxidation of intracellular proteins, lipids, and nucleic acids. Intracellular superoxide dismutase (SOD1) regulates ROS levels and plays a critical role in tissue homeostasis. Recent evidence suggests that age-associated wound healing impairments may partially result from decreased SOD1 expression. We investigated the mechanistic basis by which increased oxidative stress links to age-associated impaired wound healing. Fibroblasts were isolated from unwounded skin of young and aged mice, and myofibroblast differentiation was assessed by measuring α-smooth muscle actin and collagen gel contraction...
July 4, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28677206/imiquimod-applied-interleukin-10-deficient-mice-better-reflects-severe-and-persistent-psoriasis-with-systemic-inflammatory-state
#7
Seon-Pil Jin, Seong-Joon Koh, Da-Ae Yu, Min-Woo Kim, Hee Tae Yun, Dong Hun Lee, Hyun-Sun Yoon, Soyun Cho, Hyun-Sun Park
Previous studies have shown that imiquimod-induced psoriasis-like skin inflammation in mice resembles phenotypic changes and cytokine profiles of human psoriasis. However, a psoriasis animal model reflecting the chronic inflammatory course and comorbidities has not yet been established. We aimed to evaluate the imiquimod-applied interleukin (IL)-10 deficient mouse model in comparison to previous models. IL-10 deficient and wild type (WT) mice received either imiquimod or vehicle cream for 12 days and were sacrificed on day 15...
July 4, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28677172/neurological-and-psychiatric-associations-in-bullous-pemphigoid-more-than-skin-deep
#8
REVIEW
Anna-Kaisa Försti, Laura Huilaja, Enno Schmidt, Kaisa Tasanen
In elderly patients, bullous pemphigoid (BP) is associated with several comorbidities; the strongest association occurs between BP and neurological diseases. Different types of dementia, Parkinson's disease, cerebrovascular disorders and epilepsy all have a significant association with BP but patients with multiple sclerosis have the highest risk of BP. An existing neurological disorder appears to increase the risk for subsequent BP, but an increased risk for developing some neurological diseases has also been reported following BP diagnosis...
July 4, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28636810/the-sox2-gfp-knock-in-mouse-model-does-not-faithfully-recapitulate-sox2-expression-in-skin
#9
LETTER
Lucia Salz, Ryan R Driskell
No abstract text is available yet for this article.
June 21, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28636791/isotretinoin-and-lymecycline-treatments-modify-the-skin-microbiota-in-acne
#10
Hanna-Leena Kelhälä, Velma T E Aho, Nanna Fyhrquist, Pedro A B Pereira, Minna E Kubin, Lars Paulin, Riitta Palatsi, Petri Auvinen, Kaisa Tasanen, Antti Lauerma
Oral retinoids and tetracyclines have a major role in acne treatment. Here, we report for the first time the effect of isotretinoin and lymecycline therapy on the skin microbiota in cheek, back and armpit swab samples of acne vulgaris patients using 16S ribosomal RNA (16S rRNA) gene amplicon sequencing. Propionibacterium acnes was the most common in sebaceous areas of healthy and untreated acne skin and more abundant in back than cheek samples. Five taxa, including a Streptococcus taxon, differed significantly between the cheek samples of healthy controls and acne patients, and acne severity was positively correlated with the abundance of Propionibacterium...
June 21, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28636759/rosacea-and-its-association-with-enteral-microbiota-in-korean-females
#11
Jae-Hui Nam, Yeojun Yun, Han-Saem Kim, Han-Na Kim, Ho Joo Jung, Yoosoo Chang, Seungho Ryu, Hocheol Shin, Hyung-Lae Kim, Won-Serk Kim
Rosacea is a chronic inflammatory dermatosis affecting the face and eyes. An association between systemic comorbidities and rosacea has been reported, but the link to enteral microbiota is uncertain. We aimed to investigate the link between rosacea and enteral microbiota. A cross-sectional study was performed in a sample of Korean women who participated in a health check-up programme at the Kangbuk Samsung Hospital Health Screening Center between 23 June 2014 and 5 September 2014. The gut microbiome was evaluated by 16S rRNA gene and metagenome sequence analyses...
June 21, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28636748/e-cadherin-mediates-uvr-and-calcium-induced-melanin-transfer-in-human-skin-cells
#12
Suman K Singh, Richard Baker, Stephen K Sikkink, Carine Nizard, Sylvianne Schnebert, Robin Kurfurst, Desmond J Tobin
Skin pigmentation is directed by epidermal-melanin units, characterized by long-lived and dendritic epidermal melanocytes (MC) that interact with viable keratinocytes (KC) to contribute melanin to the epidermis. Previously we reported that MC:KC contact is required for melanosome transfer, that this can be enhanced by filopodial and by UVR/UVA irradiation, which can up-regulate melanosome transfer via Myosin X-mediated control of MC filopodia. Both MC and KC express Ca(2+) -dependent E-cadherins. These homophilic adhesion contacts induce transient increases in intra-KC Ca(2+) , while ultraviolet radiation (UVR) raises intra-MC Ca(2+) via calcium selective ORAI1 ion channels; both are associated with regulating melanogenesis...
June 21, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28620967/contribution-of-card9-mediated-signaling-to-wound-healing-in-skin
#13
Emi Kanno, Kazuyoshi Kawakami, Hiromasa Tanno, Aiko Suzuki, Noriko Sato, Airi Masaki, Ayano Imamura, Naoyuki Takagi, Takayuki Miura, Hideki Yamamoto, Keiko Ishii, Hiromitsu Hara, Yoshimichi Imai, Ryoko Maruyama, Masahiro Tachi
The inflammatory response after skin injury involves the secretion of a variety of cytokines and growth factors that are necessary for tissue repair. Caspase recruitment domain-containing protein 9 (CARD9) is an essential signaling adaptor molecule for NF-κB activation upon triggering through C-type lectin receptors (CLRs), which are expressed in macrophages and dendritic cells. However, the role of CARD9 in inflammatory responses at the wound site has not been elucidated. In the present study, we analyzed the role of CARD9 in the healing process of skin wounds...
June 16, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28605165/reg%C3%AE-accelerates-melanoma-formation-by-regulating-wnt-%C3%AE-catenin-signaling-pathway
#14
Hui Chen, Xiao Gao, Zhengwang Sun, Qingwei Wang, Di Zuo, Linian Pan, Kun Li, Jiwei Chen, Geng Chen, Kewen Hu, Ke Li, Abdus Saboor Shah, Tingmei Huang, Muhammad Zeeshan Bhatti, Lu Tong, Chan Jiao, Jian Liu, Tenghui Chen, Liangfang Yao, Yongyan Dang, Tielong Liu, Lei Li
It has been reported that the proteasome activator REGγ is associated with multiple oncogenic pathways in human cancers. However, the role of REGγ in the development of melanoma and the underlying mechanisms remain unclear. In this study, we attempted to investigate the effects of REGγ on human melanoma cell proliferation in vitro and in vivo. We demonstrated that knockdown of REGγ inhibited melanoma cell growth and arrested melanoma cell at G1 phase. Furthermore depletion of REGγ also inhibited the xenograft growth of human melanoma...
June 12, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28605064/characterization-of-the-chloroquine-induced-mouse-model-of-pruritus-using-an-automated-behavioural-system
#15
Gema Tarrasón, Carla Carcasona, Peter Eichhorn, Bibiana Pérez, Amadeu Gavaldà, Núria Godessart
Pruritus is a major symptom of several dermatological diseases but has limited therapeutic options available. Animal models replicating the pathophysiology of pruritus are needed to support the development of new drugs. Induction of pruritus by chloroquine (CQ) in mice is widely used, although, as with similar models, it has low throughput and does not distinguish between anti-pruritic effects and confounding factors such as sedation. To overcome these issues, we incorporated into the model an automated system that measures both scratching and locomotor behaviour simultaneously...
June 12, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28603863/identification-of-ptpn22-st6gal1-and-jazf1-as-psoriasis-risk-genes-demonstrates-shared-pathogenesis-between-psoriasis-and-diabetes
#16
Honglei Wang, Zhenzhen Wang, Parimi Leela Rani, Xi'an Fu, Wenjun Yu, Fangfang Bao, Gongqi Yu, Jianke Li, Lulu Li, Lele Sun, Zhenhua Yue, Qing Zhao, Qing Pan, Jing Cao, Chuan Wang, Xiaojun Chi, Yaru Wang, Qing Yang, Zihao Mi, Hong Liu, Furen Zhang
The biological connections between psoriasis and diabetes have been suggested by epidemiological, immunological and genetic studies. To identify additional shared susceptibility loci and investigate shared pathogenesis between these two diseases, we genotyped 89 reported diabetes susceptibility loci in 4,456 psoriasis cases and 6,027 controls of Chinese population using the MassARRAY system from Sequenom. We discovered three significant associations at rs6679677 on 1p13.2 (P = 6.15 × 10(-5) , OR = 5.07), rs16861329 on 3q27...
June 12, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28603914/mutation-in-il36rn-impairs-the-processing-and-regulatory-function-of-the-interleukin-36-receptor-antagonist-and-is-associated-with-ditra-syndrome
#17
Elodie Bal, Ai Ching Lim, Min Shen, Jason Douangpanya, Marine Madrange, Rihab Gazah, Marie Tauber, Walid Beghdadi, Jean Laurent Casanova, Emmanuelle Bourrat, Hervé Bachelez, Jennifer E Towne, Asma Smahi
No abstract text is available yet for this article.
June 11, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28603906/atopic-skin-in-vivo-raman-identification-of-global-molecular-signature-a-comparative-study-with-healthy-skin
#18
L Verzeaux, R Vyumvuhore, D Boudier, M Le Guillou, S Bordes, M Essendoubi, M Manfait, B Closs
Atopic dermatitis (AD) is the most common skin inflammatory disease, affecting up to 3% of adults and 20% of children. Skin barrier impairment is thought to be the primary factor in this disease. Currently, there is no method proposed to monitor non-invasively the different molecular disorders involved in the upper layer of AD skin. Raman microspectroscopy has proved to be a powerful tool to characterize some AD molecular descriptors such as lipid content, global hydration level, filaggrin and its derivatives...
June 11, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28603898/getting-to-the-root-of-scales-feather-and-hair-as-deep-as-odontodes
#19
Danielle Dhouailly, Pascal Godefroit, Thomas Martin, Stefan Nonchev, Flavien Caraguel, Olav Oftedal
While every jawed vertebrate, or its recent ancestor, possesses teeth, skin appendages are characteristic of the living clades: skin denticles (odontodes) in chondrichthyians, dermal scales in teleosts, ducted multicellular glands in amphibians, epidermal scales in squamates, feathers in birds, and hair-gland complexes in mammals, all of them showing a dense periodic patterning. While the odontode origin of teleost scales is generally accepted, the origin of both feather and hair is still debated. They appear long before mammals and birds, at least in Jurassic in mammaliaforms and in ornithodires (pterosaurs and dinosaurs), and are contemporary to scales of early squamates...
June 11, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28603853/a-3d-in-vitro-model-of-the-re-epithelialization-phase-in-the-wound-healing-process
#20
Nathalie Deshayes, Fabienne Bloas, Florian Boissout, Jennifer Lecardonnel, Maryline Paris
No abstract text is available yet for this article.
June 11, 2017: Experimental Dermatology
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