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Experimental Dermatology

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https://www.readbyqxmd.com/read/28267869/analysis-of-the-skin-of-mice-humanized-for-the-immune-system
#1
LETTER
Mireille Centlivre, Maxime Petit, Andrew J Hutton, Mélody Dufossée, David Boccara, Maurice Mimoun, Angèle Soria, Béhazine Combadière
No abstract text is available yet for this article.
March 7, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28266782/systemic-immune-mechanisms-in-atopic-dermatitis-and-psoriasis-with-implications-for-treatment
#2
REVIEW
Emma Guttman-Yassky, James G Krueger, Mark G Lebwohl
Atopic dermatitis (AD) and psoriasis are inflammatory skin diseases that negatively affect patients' quality of life. Although distinctions exist between these diseases, both are characterised by erythematous, thickened epidermal lesions that vary in intensity and affected body surface area. Early models of etiology attributed symptoms of both diseases to cutaneous inflammation at lesion sites, but recent studies have established that activated immune mediators in the circulation drive disease severity. Activation of T helper 2 (Th2) and Th22 cells in the circulation appears to be the principal initiator of acute AD pathology, with the emergence of Th1 and Th17/interleukin (IL)-23 pathway activation marking the transition to a chronic state...
March 7, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28266778/hematoxylin-and-eosin-staining-identifies-medium-to-large-bacterial-aggregates-with-a-reliable-specificity-a-comparative-analysis-of-follicular-bacterial-aggregates-in-axillary-biopsies-using-pna-fish-and-hematoxylin-and-eosin-staining
#3
H C Ring, P Theut Riis, L Bay, K Kallenbach, T Bjarnsholt, G B Jemec
BACKGROUND: Although Peptide Nucleic Acid (PNA) - Fluorescence in situ Hybridization (FISH) and Confocal Laser Scanning Microscopy (CLSM) is the reference tool in the study of bacterial aggregates/biofilms, it may also be rather time-consuming. This study aimed to investigate the sensitivity and specificity between bacterial aggregates identified by Hematoxylin and Eosin (HE) staining versus bacterial aggregates in corresponding PNA-FISH samples. METHOD: Axillary biopsies were obtained in 24 healthy controls...
March 7, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28266764/type-iv-collagen-aggregates-promote-keratinocyte-proliferation-and-formation-of-epidermal-layer-in-human-skin-equivalents
#4
Yuko Matsuura-Hachiya, Koji Y Arai, Taichi Muraguchi, Tasuku Sasaki, Toshio Nishiyama
Type IV collagen isolated from lens capsule without enzymatic treatment is known to form a gel under physiological condition and influences cellular activities. In case of human keratinocytes, the suppression of proliferation on reconstituted type IV collagen gels was reported in monolayer culture. In this study, we examined effects of type IV collagen isolated from porcine lens capsule on epidermal formation in human skin equivalents. Type IV collagen aggregates were prepared under the culture condition and the aggregates suppressed keratinocyte proliferation in monolayer culture as well as the culture on the gels...
March 7, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28266752/increased-levels-of-circulating-platelet-derived-microparticles-is-associated-with-metastatic-cutaneous-melanoma
#5
LETTER
Joséphine Moreau, Fabien Pelletier, Sabeha Biichle, Guillaume Mourey, Marc Puyraveau, Nicolas Badet, Matthieu Caubet, Claire Laresche, Francine Garnache-Ottou, Philippe Saas, Estelle Seilles, François Aubin
No abstract text is available yet for this article.
March 7, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28266743/the-hair-follicle-enigma
#6
Bruno A Bernard
The hair follicle is a mini organ endowed with a unique structure and cyclic behavior. Despite the intense research efforts which have been devoted at deciphering the hair follicle biology over the past 70 years, one must admit that hair follicle remains an enigma. In this brief review, various aspects of hair follicle biology will be addressed, and more importantly, unsolved questions and new possible research tracks will be highlighted, including hair follicle glycobiology and exosome mediated cell-cell interactions...
March 7, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28266741/signaling-and-targeted-therapy-of-inflammatory-cells-in-epidermolysis-bullosa-acquisita
#7
REVIEW
Ralf J Ludwig
Pemphigoid diseases (PD) are chronic and life-threating autoimmune diseases of the skin and mucous membranes. PD are characterized and caused by autoantibodies targeting components of the basement membrane. In the PD epidermolysis bullosa acquisita (EBA) the target autoantigen is type VII collagen. Current treatment options of PD, especially EBA, are limited and are mostly based on systemic immunosuppression. Animal models of PD have greatly advanced our understanding of PD pathogenesis. This has led to the identification of several novel therapeutic targets, including signaling molecules...
March 7, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28266738/the-how-why-and-clinical-importance-of-stratum-corneum-acidification
#8
Peter M Elias
In this article, I review the multiple endogenous mechanisms that contribute to the highly acidic pH of normal stratum corneum (SC). Then, I describe how each mechanism potentially impacts specific defensive functions of the SC. Finally, I review the rapidly expanding, clinical implications and potential therapeutic applications of SC acidification. This article is protected by copyright. All rights reserved.
March 7, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28266737/epidermal-keratinocytes-sense-dsrna-via-the-nlrp3-inflammasome-mediating-interleukin-il-1%C3%AE-and-il-18-release
#9
Xiuju Dai, Mikiko Tohyama, Masamoto Murakami, Koji Sayama
Skin epidermis, in addition to its barrier function, is able to actively sense harmful pathogens using pattern recognition receptors. In immune cells, the nucleotide-binding oligomerization domain, leucine-rich repeat, pyrin domain containing 3 (NLRP3) inflammasome can mediate innate immunity against viral infection via a mechanism involving viral dsRNA recognition. Epidermal keratinocytes express NLRP3 inflammasome, which can sense contact sensitizers and mite allergens, leading to pro-interleukin (IL)-1β and pro-IL-18 cleavage into their active forms...
March 7, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28266733/a-pulmonary-metastatic-model-of-murine-melanoma-assessed-by-magnetic-resonance-imaging
#10
Takafumi Numata, Shigeru Kiryu, Tatsuo Maeda, Chizu Egusa, Ryoji Tsuboi, Kazutoshi Harada
BACKGROUND: Immune checkpoint inhibitors and kinase inhibitors have improved prognosis of malignant melanoma (MM) patients. However these therapies cannot completely overcome the metastasis of MM. Thus development of new therapy against metastasis should be required. A first step towards this goal, the aim of this study, is to establish a model of pulmonary metastasis from primary cutaneous MM and a monitoring system. EXPERIMENTAL DESIGN: B16-F10, a murine melanoma cell line, was subcutaneously injected into the pinna of mice...
March 7, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28266729/infundibular-protein-and-rna-microarray-analyses-from-affected-and-clinically-non-affected-scalp-in-male-androgenetic-alopecia-patients
#11
LETTER
Annika Vogt, Eva K B Pfannes, Sabine Fimmel, Sabrina Hadam, Annette Andruck, Jan Kottner, Ulrike Blume-Peytavi
No abstract text is available yet for this article.
March 7, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28266728/genetic-3-utr-variation-is-associated-with-human-pigmentation-characteristics-and-sensitivity-to-sunlight
#12
Barbara Hernando, Maria Peña-Chilet, Maider Ibarrola-Villava, Manuel Martin-Gonzalez, Cristina Gomez-Fernandez, Gloria Ribas, Conrado Martinez-Cadenas
Sunlight exposure induces signalling pathways leading to the activation of melanin synthesis and tanning response. MicroRNAs (miRNAs) can regulate the expression of genes involved in pigmentation pathways by binding to the complementary sequence in their 3'-untrastaled regions (3'UTRs). Therefore, 3'UTR SNPs are predicted to modify the ability of miRNAs to target genes, resulting in differential gene expression. In this study, we investigated the role in pigmentation and sun-sensitivity traits, as well as in melanoma susceptibility, of 38 different 3'UTR SNPs from 38 pigmentation-related genes...
March 7, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28266727/autoantibodies-of-non-inflammatory-bullous-pemphigoid-hardly-deplete-type-xvii-collagen-of-keratinocytes
#13
LETTER
Keisuke Imafuku, Hiroaki Iwata, Mayumi Kamaguchi, Kentaro Izumi, Ken Natsuga, Hideyuki Ujiie, Wataru Nishie, Hiroshi Shimizu
No abstract text is available yet for this article.
March 7, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28266726/uv-adaptation-pigmentation-and-protection-against-overexposure
#14
REVIEW
Frank R de Gruijl
The skin is known to adapt to UV exposures, i.e., become less sensitive to sunburn. Reported decreases in sensitivity vary widely from well over 10 fold down to a negligible 10%. This appears to depend importantly on the UV irradiation spectrum to which the skin adapts and on the UV irradiation spectrum that is used to test the sensitivity. The sensitivity is conventionally and generally assessed by the reciprocal of the minimal erythema dose (MED): the UV dose causing a just perceptible reddening of the skin after 8 - 24 h...
March 7, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28266725/the-kollias-legacy-skin-autofluorescence-and-beyond
#15
Paulo R Bargo, Apostolos Doukas, Salvador González, Gopinathan Menon, Apostolos Pappas, Eduardo C Ruvolo, Georgios N Stamatas
In a paper published at the J Invest Dermatol in 1998 Nik Kollias and coworkers described distinct changes in skin native fluorescence associated with skin aging and photoaging, using in vivo fluorescence excitation spectroscopy. The assignment of the 295 nm band to tryptophan fluorescence had a profound significance influencing many later studies from multiple groups. The reproducible changes in skin native fluorescence suggested that aging causes predictable alterations in both the epidermis and the dermis, whereas chronic UV exposure induces the appearance of new fluorophores...
March 7, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28192606/metformin-alleviates-aging-cellular-phenotypes-in-hutchinson-gilford-progeria-syndrome-dermal-fibroblasts
#16
Seul-Ki Park, Ok Sarah Shin
Metformin is a popular antidiabetic biguanide, which has been considered as a candidate drug for cancer treatment and aging prevention. Hutchinson-Gilford progeria syndrome (HGPS) is a devastating disease characterized by premature aging and severe age-associated complications leading to death. The effects of metformin on HGPS dermal fibroblasts remain largely undefined. In this study, we investigated whether metformin could exert a beneficial effect on nuclear abnormalities and delay senescence in fibroblasts derived from HGPS patients...
February 13, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28191690/mutational-profiling-of-acral-melanomas-in-korean-populations
#17
Joon Ho Shim, Hyun-Tae Shin, Jiho Park, Ji-Hye Park, Jong-Hee Lee, Jun-Mo Yang, Duk-Hwan Kim, Kee-Taek Jang, Dong-Youn Lee
The proportion of acral melanoma (AM) is much higher in Asian populations than in Caucasians populations. Although mutational profiles associated with AM have been discovered in Caucasian populations, knowledge of its genetic alterations in the Asian populations is limited. To describe the molecular nature of AM in Korean patients, we performed mutational profilinge of AM and matched normal tissues of in patients. Fifty-one formalin-fixed paraffin-embedded AM samples and 32 matched pairs of from patients' saliva DNA were analyzed by next-generation sequencing...
February 13, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28191688/functional-expression-of-olfactory-receptors-in-human-primary-melanoma-and-melanoma-metastasis
#18
Lian Gelis, Nikolina Jovancevic, Falk Bechara, Eva M Neuhaus, Hanns Hatt
We identified the olfactory receptor 51E2 in human melanoma and have measured both OR51E2 mRNA and protein expression in melanoma tissue sections. qPCR analysis revealed that the receptor is upregulated in melanoma cells compared to normal melanocytes, indicating that OR51E2 may play a role in early melanoma development and progression. Activation of endogenous OR51E2 in cultured cells derived from metastatic and vertical-growth phase (VGP) by its ligand β-ionone results in an increase in the intracellular Ca(2+) concentration...
February 13, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28191683/immediate-type-allergic-and-protease-mediated-reactions-are-involved-in-scratching-behavior-induced-by-topical-application-of-dermatophagoides-farinae-extract-in-nc-nga-mice
#19
Yoshihito Yamada, Yuhki Ueda, Aki Nakamura, Shoji Kanayama, Rie Tamura, Kei Hashimoto, Tatsumi Matsumoto, Ritsuko Ishii
Atopic dermatitis (AD)-like dermatitis can be induced by repeated topical application of an ointment containing Dermatophagoides farinae body (Dfb) extract in NC/Nga mice. This AD-like murine model also exhibits a biphasic increase in the number of scratching behavior after topical application of Dfb ointment. In this study, we investigated the possible mechanisms underlying the scratching behavior in each phase. An increase in the content of mast cell derived mediators such as histamine and 5-hydroxytryptamine in the lesional skin and increased vascular permeability were observed in the early phase after the Dfb ointment application...
February 13, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28191680/friends-or-foes-host-defense-antimicrobial-peptides-and-proteins-in-human-skin-diseases
#20
REVIEW
François Niyonsaba, Chanisa Kiatsurayanon, Panjit Chieosilapatham, Hideoki Ogawa
Host defense peptides/proteins (HDPs), also known as antimicrobial peptides/proteins (AMPs), are key molecules in the cutaneous innate immune system. AMPs/HDPs historically exhibit broad-spectrum killing activity against bacteria, enveloped viruses, fungi and several parasites. Recently, AMPs/HDPs were shown to have important biological functions, including inducing cell proliferation, migration and differentiation; regulating inflammatory responses; controlling the production of various cytokines/chemokines; promoting wound healing; and improving skin barrier function...
February 13, 2017: Experimental Dermatology
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