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Experimental Dermatology

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https://www.readbyqxmd.com/read/28636810/the-sox2-gfp-knock-in-mouse-model-does-not-faithfully-recapitulate-sox2-expression-in-skin
#1
LETTER
Lucia Salz, Ryan R Driskell
No abstract text is available yet for this article.
June 21, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28636791/isotretinoin-and-lymecycline-treatments-modify-the-skin-microbiota-in-acne
#2
Hanna-Leena Kelhälä, Velma T E Aho, Nanna Fyhrquist, Pedro A B Pereira, Minna E Kubin, Lars Paulin, Riitta Palatsi, Petri Auvinen, Kaisa Tasanen, Antti Lauerma
Oral retinoids and tetracyclines have a major role in acne treatment. Here, we report for the first time the effect of isotretinoin and lymecycline therapy on the skin microbiota in cheek, back and armpit swab samples of acne vulgaris patients using 16S ribosomal RNA (16S rRNA) gene amplicon sequencing. Propionibacterium acnes was the most common in sebaceous areas of healthy and untreated acne skin and more abundant in back than cheek samples. Five taxa, including a Streptococcus taxon, differed significantly between the cheek samples of healthy controls and acne patients, and acne severity was positively correlated with the abundance of Propionibacterium...
June 21, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28636759/rosacea-and-its-association-with-enteral-microbiota-in-korean-females
#3
Jae-Hui Nam, Yeojun Yun, Han-Saem Kim, Han-Na Kim, Ho Joo Jung, Yoosoo Chang, Seungho Ryu, Hocheol Shin, Hyung-Lae Kim, Won-Serk Kim
BACKGROUND: Rosacea is a chronic inflammatory dermatosis affecting the face and eyes. An association between systemic comorbidities and rosacea has been reported, but the link to enteral microbiota is uncertain. OBJECTIVES: We aimed to investigate the link between rosacea and enteral microbiota. METHODS: A cross-sectional study was performed in a sample of Korean women who participated in a health checkup program at the Kangbuk Samsung Hospital Health Screening Center between 23 June 2014 and 5 September 2014...
June 21, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28636748/e-cadherin-mediates-uvr-and-calcium-induced-melanin-transfer-in-human-skin-cells
#4
Suman K Singh, Richard Baker, Stephen K Sikkink, Carine Nizard, Sylvianne Schnebert, Robin Kurfurst, Desmond J Tobin
Skin pigmentation is directed by epidermal-melanin units, characterized by long-lived and dendritic epidermal melanocytes (MC) that interact with viable keratinocytes (KC) to contribute melanin to the epidermis. Previously we reported that MC:KC contact is required for melanosome transfer, that this can be enhanced by filopodial and by UVR/UVA irradiation, which can up-regulate melanosome transfer via Myosin X-mediated control of MC filopodia. Both MC and KC express Ca(2+) -dependent E-cadherins. These homophilic adhesion contacts induce transient increases in intra-KC Ca(2+) , while ultraviolet radiation (UVR) raises intra-MC Ca(2+) via calcium selective ORAI1 ion channels; both are associated with regulating melanogenesis...
June 21, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28620967/contribution-of-card9-mediated-signaling-to-wound-healing-in-skin
#5
Emi Kanno, Kazuyoshi Kawakami, Hiromasa Tanno, Aiko Suzuki, Noriko Sato, Airi Masaki, Ayano Imamura, Naoyuki Takagi, Takayuki Miura, Hideki Yamamoto, Keiko Ishii, Hiromitsu Hara, Yoshimichi Imai, Ryoko Maruyama, Masahiro Tachi
The inflammatory response after skin injury involves the secretion of a variety of cytokines and growth factors that are necessary for tissue repair. Caspase recruitment domain-containing protein 9 (CARD9) is an essential signaling adaptor molecule for NF-κB activation upon triggering through C-type lectin receptors (CLRs), which are expressed in macrophages and dendritic cells. However, the role of CARD9 in inflammatory responses at the wound site has not been elucidated. In the present study, we analyzed the role of CARD9 in the healing process of skin wounds...
June 16, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28605165/reg%C3%AE-accelerates-melanoma-formation-by-regulating-wnt-%C3%AE-catenin-signaling-pathway
#6
Hui Chen, Xiao Gao, Zhengwang Sun, Qingwei Wang, Di Zuo, Linian Pan, Kun Li, Jiwei Chen, Geng Chen, Kewen Hu, Ke Li, Abdus Saboor Shah, Tingmei Huang, Muhammad Zeeshan Bhatti, Lu Tong, Chan Jiao, Jian Liu, Tenghui Chen, Liangfang Yao, Yongyan Dang, Tielong Liu, Lei Li
It has been reported that the proteasome activator REGγ is associated with multiple oncogenic pathways in human cancers. However, the role of REGγ in the development of melanoma and the underlying mechanisms remain unclear. In this study, we attempted to investigate the effects of REGγ on human melanoma cell proliferation in vitro and in vivo. We demonstrated that knockdown of REGγ inhibited melanoma cell growth and arrested melanoma cell at G1 phase. Furthermore depletion of REGγ also inhibited the xenograft growth of human melanoma...
June 12, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28605064/characterization-of-the-chloroquine-induced-mouse-model-of-pruritus-using-an-automated-behavioural-system
#7
Gema Tarrasón, Carla Carcasona, Peter Eichhorn, Bibiana Pérez, Amadeu Gavaldà, Núria Godessart
Pruritus is a major symptom of several dermatological diseases but has limited therapeutic options available. Animal models replicating the pathophysiology of pruritus are needed to support the development of new drugs. Induction of pruritus by chloroquine (CQ) in mice is widely used, although, as with similar models, it has low throughput and does not distinguish between anti-pruritic effects and confounding factors such as sedation. To overcome these issues, we incorporated into the model an automated system that measures both scratching and locomotor behaviour simultaneously...
June 12, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28603863/identification-of-ptpn22-st6gal1-and-jazf1-as-psoriasis-risk-genes-demonstrates-shared-pathogenesis-between-psoriasis-and-diabetes
#8
Honglei Wang, Zhenzhen Wang, Parimi Leela Rani, Xi'an Fu, Wenjun Yu, Fangfang Bao, Gongqi Yu, Jianke Li, Lulu Li, Lele Sun, Zhenhua Yue, Qing Zhao, Qing Pan, Jing Cao, Chuan Wang, Xiaojun Chi, Yaru Wang, Qing Yang, Zihao Mi, Hong Liu, Furen Zhang
The biological connections between psoriasis and diabetes have been suggested by epidemiological, immunological and genetic studies. To identify additional shared susceptibility loci and investigate shared pathogenesis between these two diseases, we genotyped 89 reported diabetes susceptibility loci in 4,456 psoriasis cases and 6,027 controls of Chinese population using the MassARRAY system from Sequenom. We discovered three significant associations at rs6679677 on 1p13.2 (P = 6.15 × 10(-5) , OR = 5.07), rs16861329 on 3q27...
June 12, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28603914/mutation-in-il36rn-impairs-the-processing-and-regulatory-function-of-the-interleukin-36-receptor-antagonist-and-is-associated-with-ditra-syndrome
#9
Elodie Bal, Ai Ching Lim, Min Shen, Jason Douangpanya, Marine Madrange, Rihab Gazah, Marie Tauber, Walid Beghdadi, Jean Laurent Casanova, Emmanuelle Bourrat, Hervé Bachelez, Jennifer E Towne, Asma Smahi
No abstract text is available yet for this article.
June 11, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28603906/atopic-skin-in-vivo-raman-identification-of-global-molecular-signature-a-comparative-study-with-healthy-skin
#10
L Verzeaux, R Vyumvuhore, D Boudier, M Le Guillou, S Bordes, M Essendoubi, M Manfait, B Closs
Atopic dermatitis (AD) is the most common skin inflammatory disease, affecting up to 3% of adults and 20% of children. Skin barrier impairment is thought to be the primary factor in this disease. Currently, there is no method proposed to monitor non-invasively the different molecular disorders involved in the upper layer of AD skin. Raman microspectroscopy has proved to be a powerful tool to characterize some AD molecular descriptors such as lipid content, global hydration level, filaggrin and its derivatives...
June 11, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28603898/getting-to-the-root-of-scales-feather-and-hair-as-deep-as-odontodes
#11
Danielle Dhouailly, Pascal Godefroit, Thomas Martin, Stefan Nonchev, Flavien Caraguel, Olav Oftedal
While every jawed vertebrate, or its recent ancestor, possesses teeth, skin appendages are characteristic of the living clades: skin denticles (odontodes) in chondrichthyians, dermal scales in teleosts, ducted multicellular glands in amphibians, epidermal scales in squamates, feathers in birds, and hair-gland complexes in mammals, all of them showing a dense periodic patterning. While the odontode origin of teleost scales is generally accepted, the origin of both feather and hair is still debated. They appear long before mammals and birds, at least in Jurassic in mammaliaforms and in ornithodires (pterosaurs and dinosaurs), and are contemporary to scales of early squamates...
June 11, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28603853/a-3d-in-vitro-model-of-the-re-epithelialization-phase-in-the-wound-healing-process
#12
Nathalie Deshayes, Fabienne Bloas, Florian Boissout, Jennifer Lecardonnel, Maryline Paris
No abstract text is available yet for this article.
June 11, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28500685/analysis-of-serum-markers-of-cellular-immune-activation-in-patients-with-bullous-pemphigoid
#13
Katja Bieber, Anna Lara Ernst, Stefan Tukaj, Maike M Holtsche, Enno Schmidt, Detlef Zillikens, Ralf J Ludwig, Michael Kasperkiewicz
Experimental models of bullous pemphigoid (BP), the most frequent subepidermal autoimmune bullous disease, revealed that the immune response leading to blister formation represents an incompletely understood complex process involving different inflammatory cells. In contrast to previous reports commonly focusing on limited molecular and cellular phenotypes of the disease, the aim of this study was to investigate a broad spectrum of markers of cellular immune activation in patients with BP. We found that serum levels of soluble CD4, myeloperoxidase, S100A12, eosinophil cationic protein, and soluble P-selectin were significantly elevated in patients with active BP compared with normal controls...
May 13, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28500679/red-tattoos-ultraviolet-radiation%C3%A2-and-skin-cancer-in-mice
#14
Catharina M Lerche, Ida M Heerfordt, Jørgen Serup, Thomas Poulsen, Hans Christian Wulf
Ultraviolet radiation (UVR) induces skin cancer. The combination of UVR and red tattoos may be associated with increased risk of skin cancer due to potential carcinogens in tattoo inks. This combination has not been studied previously. Immunocompetent C3.Cg/TifBomTac hairless mice (n=99) were tattooed on their back with a popular red tattoo ink. This often used ink is banned for use on humans because of high content of the potential carcinogen 2-anisidine. Half of the mice were irradiated with three standard erythema doses UVR thrice weekly...
May 13, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28500634/inhibition-of-mast-cell-infiltration-in-an-ll-37-induced-rosacea-mouse-model-using-topical-brimonidine-tartrate-0-33-gel
#15
LETTER
Miri Kim, Jongsic Kim, Seo-Won Jeong, Hyunmu Jo, Yu Ri Woo, Hyun Jeong Park
No abstract text is available yet for this article.
May 13, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28482119/silencing-of-homeobox-a5-gene-in-the-stratum-corneum-of-psoriasis
#16
Yoshimasa Nobeyama, Yoshinori Umezawa, Hidemi Nakagawa
Analysis of psoriatic parakeratotic cells is helpful for understanding the pathogenesis of psoriasis. Methylation analysis can be performed on psoriatic scales, but it is unclear whether genes can be silenced by DNA methylation in psoriatic stratum corneum. The present study was conducted to detect genes silenced in psoriatic stratum corneum. Methylation array analysis with 485,577 probes, quantitative real-time methylation-specific PCR (RT-MSP) and bisulfite sequencing were performed for 30 psoriatic scale samples, 6 fully developed psoriatic skin samples and 12 normal skin samples...
May 8, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28482118/autoantigens-adamtsl5-and-ll37-are-significantly-upregulated-in-active-psoriasis-and-localized-with-keratinocytes-dendritic-cells-and-other-leukocytes
#17
Judilyn Fuentes-Duculan, Kathleen M Bonifacio, Jason E Hawkes, Norma Kunjravia, Inna Cueto, Xuan Li, Juana Gonzalez, Sandra Garcet, James G Krueger
Psoriasis is a common immune-mediated disease that affects 2-4% of individuals in North America and Europe. In the past decade, advances in research have led to an improved understanding of immune pathways involved in the pathogenesis of psoriasis and has spurred the development of targeted therapeutics. Recently, three psoriasis autoantigens have been described: cathelicidin (LL37), a disintegrin and metalloprotease domain containing thrombospondin type 1 motif-like 5 (ADAMTSL5), and lipid antigens generated by phospholipase A2 (PLA2) group IVD (PLA2G4D)...
May 8, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28480983/effects-of-two-chronic-stresses-on-mental-state-and-hair-follicle-melanogenesis-in-mice
#18
Sha Liao, Jinpeng Lv, Jia Zhou, Praveen Kumar Kalavagunta, Jing Shang
Growing bodies of data show that psychological stress can be associated with hair loss and vitiligo. Researchers have revealed that stress could indeed inhibit hair growth in vivo, but the relationship between chronic stress and melanogenesis remains unknown. In this study, we established two types of stress models, chronic restraint stress (CRS) and chronic unpredicted mild stress (CUMS) mice models, and explored the possible role of stress in mice hair follicle melanogenesis. We found that stress changed hippocampal morphology, decreased 5-HT level in brain and skin and down-regulated 5-HT1A receptor expression in hippocampal CA1 region and skin...
May 8, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28453925/pkc%C3%AE-is-a-target-of-7-8-4-trihydroxyisoflavone-for-the-suppression-of-uvb-induced-mmp-1-expression
#19
Tae-Gyu Lim, Yoon-A Kim, Jong-Eun Kim, Sohee Baek, Sung-Young Lee, Charles C Lee, Hanyong Chen, Jong Rhan Kim, Jung Yeon Kwon, Ann M Bode, Chang Yong Lee, Zigang Dong, Deok-Kun Oh, Jun Seong Park, Ki Won Lee
No abstract text is available yet for this article.
April 28, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28453913/bioprinting-of-biomimetic-skin-containing-melanocytes
#20
Daejin Min, Wonhye Lee, Il-Hong Bae, Tae Ryong Lee, Phillip Croce, Seung-Schik Yoo
This study reports a three-dimensional (3D) bioprinting technique that is capable of producing a full-thickness skin model containing pigmentation. Multiple layers of fibroblasts (FB)-containing collagen hydrogel precursor were printed and crosslinked through neutralization using sodium bicarbonate, constituting the dermal layer. Melanocytes (MC) and keratinocytes (KC) were sequentially printed on top of the dermal layer to induce skin pigmentation upon subsequent air-liquid interface culture. Histological analysis was performed not only to confirm the formation of distinct skin layers, but also to identify the presence of pigmentation...
April 28, 2017: Experimental Dermatology
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