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Blood Pressure

Anneli Talvik, Paola Rebora, Marika Heinpalu-Kuum, Sabrina Salerno, Eliza Miszkowska-Nagórna, Xiaoqiu Liu, Tommaso Comotti, Ewa Świerblewska, Maria Grazia Valsecchi, Fadl Elmula M Fadl Elmula, Anne Cecilie Larstorp, Krzysztof Narkiewicz, Gianfranco Parati, Stéphane Laurent, Margus Viigimaa
BACKGROUND: In the BEAUTY study we investigated whether utilizing non-invasive monitoring of hemodynamic parameters combined with a drug selection algorithm (integrated hemodynamic management-IHM) compared to conventional drug selection may improve home BP in patients with uncontrolled hypertension. METHODS: Uncontrolled (office systolic blood pressure (SBP) > 140 mmHg and ambulatory daytime SBP >135 mmHg while taking ≥2 antihypertensive drugs) essential hypertensive patients were referred to 5 European Hypertension Excellence Centers and, if eligible, were randomized into IHM-guided vs conventional treatment adjustment...
August 21, 2018: Blood Pressure
Ewa Świerblewska, Jacek Wolf, Katarzyna Kunicka, Beata Graff, Katarzyna Polonis, Michał Hoffmann, Marzena Chrostowska, Anna Szyndler, Piotr Bandosz, Beata Graff, Krzysztof Narkiewicz
BACKGROUND: Although the presence of sub-clinical left ventricular diastolic dysfunction (LVDD) increases cardiovascular risk, the current ESH/ESC guidelines do not include the presence of this condition in the list of target organ damage or cardiovascular risk charts dedicated to the hypertensive population. Several conditions may predict the LVDD occurrence, however, clustering of these factors with hypertension makes the relationship less clear. Therefore, the aim of this study was to evaluate both the occurrence and the severity of diastolic dysfunction in a large cohort of treated hypertensives...
August 21, 2018: Blood Pressure
Géraldine Petit, Elena Berra, Coralie M G Georges, Arnaud Capron, Qi-Fang Huang, Marilucy Lopez-Sublet, Franco Rabbia, Jan A Staessen, Pierre Wallemacq, Philippe de Timary, Alexandre Persu
PURPOSE: Patients with apparent treatment-resistant hypertension (a-TRH) are often poorly adherent to drug treatment and have an unusual personal history and psychological profile. The aim of this study was to identify predictors of drug adherence and drug resistance in a cohort of patients with aTRH, with emphasis on psychological characteristics. METHODS: All patients with confirmed aTRH on standardized antihypertensive treatment were eligible. Drug adherence was assessed by drug dosages in urine using Liquid Chromatography coupled with tandem Mass Spectrometry (LC-MS/MS)...
June 28, 2018: Blood Pressure
Sverre E Kjeldsen, Krzysztof Narkiewicz, Michel Burnier, Suzanne Oparil
No abstract text is available yet for this article.
October 2018: Blood Pressure
Ragab A Mahfouz, Mohammad Goda, Islam Galal, Mohamed S Ghareb
Background & hypothesis: We hypothesized that exaggerated morning blood pressure surge, may contribute in cardiac dysfunction and arterial stiffness in patients with cardiac syndrome X. Thus we investigated the impact of morning blood pressure surge on cardiac function and carotid intima-media thickness in subjects with cardiac syndrome X. METHODS: We studied patients with cardiac syndrome X using ambulatory blood pressure monitoring and investigated the association of morning blood pressure surge with carotid intima thickness, left atrial volume index and left ventricular filling (E/e')...
October 2018: Blood Pressure
Joanna Kanarek-Kucner, Adrian Stefański, Rufus Barraclough, Tomasz Gorycki, Jacek Wolf, Krzysztof Narkiewicz, Michał Hoffmann
BACKGROUND: Primary aldosteronism (PA) is the most common cause of secondary hypertension and bilateral adrenal hyperplasia (BAH) and aldosterone-producing adenoma (APA) seem to be the most common causes of PA. Unilateral adrenalectomy (UA) is the preferred treatment for APA, although the benefits are still difficult to assess. CASE REPORT: We present a case report of a 69-year old man with a 30 year history of hypertension and probably long-standing PA due to APA, with typical organ complications...
October 2018: Blood Pressure
Monesha Gupta-Malhotra, Syed Shahrukh Hashmi, Michelle S Barratt, Dianna M Milewicz, Sanjay Shete
PURPOSE: Determining familial aggregation is an important first step in narrowing the search for disease-causing genes and hence we determined the familial aggregation of EH among first degree relatives of children with EH. MATERIALS AND METHODS: We prospectively enrolled children with EH along with their first degree relatives from a tertiary pediatric hypertension clinic in a large ambulatory care center. We utilized rigorous methodology for blood pressure (BP) measurements and diagnoses of EH to reduce the heterogeneity in the phenotype...
October 2018: Blood Pressure
Leoné Malan, Andrea de Kock, Mark Hamer, Marike Cockeran, Nicolaas Theodor Malan
OBJECTIVES: Taxing psychosocial stress and defensive coping have been associated with hypoactivity in cortisol, a vasoconstrictive agent. Estradiol has vasodilatory properties with cardio- and neuroprotective effects. It can however also induce α1 -adrenergic vasoconstrictive responsiveness. We aimed to determine whether the cortisol-to-estradiol ratio (Cort:E2) may augment α1 -adrenergic responsiveness and hypertension risk when habitually using defensive coping. METHODS: African (n = 168) and Caucasian (n = 207) men and women (46 ± 9 years) were included...
October 2018: Blood Pressure
Mark R de Jong, Annemiek F Hoogerwaard, Ahmet Adiyaman, Jaap Jan J Smit, Jan-Evert Heeg, Boudewijn A A M van Hasselt, Anand R Ramdat Misier, Arif Elvan
PURPOSE: Recently we reported the use of renal nerve stimulation (RNS) during renal denervation (RDN) procedures. RNS induced changes in blood pressure (BP) and heart rate are not fully delineated yet. We hypothesized that electrical stimulation of the sympathetic nerve tissue in the renal artery would lead to an increase in BP and vagal stimulation would cause a decrease in BP. We report the different patterns of BP and heart rate responses elicited by RNS prior to RDN. METHODS: 35 patients with drug-resistant hypertension were included...
October 2018: Blood Pressure
Alessandro Maloberti, Francesca Farina, Marco Carbonaro, Enrico Piccinelli, Ilaria Bassi, Francesco Pansera, Guido Grassi, Giuseppe Mancia, Paola Palestini, Cristina Giannattasio
PURPOSE: Only few studies evaluated biomarkers useful for defining the cardiovascular risk of a subject in a pre-clinical condition (i.e. healthy subjects). In this context we sought to determine the relationships of Plasminogen activator inhibitor type 1 (PAI-1), P-Selectin, Tissue Inhibitors Metalloproteinases type 1 (TIMP-1) and Cystatin-C with subclinical Target Organ Damage (TOD) in normotensive and normoglycemic subjects without known cardiovascular and kidney diseases. MATERIALS AND METHODS: 480 blood donors participated at the present analysis...
October 2018: Blood Pressure
Jitka Seidlerová, Julius Gelžinský, Markéta Mateřánková, Jiří Ceral, Petr König, Jan Filipovský
AIMS: Several papers reported that unattended automated office blood pressure (uAutoOBP) is closely related to daytime ambulatory blood pressure monitoring (ABPM). In the present study, we aim to study uAutoOBP and its relation to 24-hour ABPM and ABPM variability. MATERIAL AND METHODS: Stable treated hypertensive subjects were examined in two Czech academic hypertension centres. uAutoOBP was measured with the BP Tru device; attended BP three times with auscultatory method (AuscOBP) by the physician...
October 2018: Blood Pressure
Joakim Olbers, Adam Gille, Petter Ljungman, Mårten Rosenqvist, Jan Östergren, Nils Witt
PURPOSE: Atrial fibrillation (AF) is associated with an increased risk for cardiovascular morbidity and mortality, not entirely explained by thromboembolism. The underlying mechanisms for this association are largely unknown. Similarly, high blood pressure (BP) increases the risk for cardiovascular events. Despite this the interplay between AF and BP is insufficiently studied. The purpose of this study was to examine and quantify the beat-to-beat blood pressure variability in patients with AF in comparison to a control group of patients with sinus rhythm...
October 2018: Blood Pressure
Sverre E Kjeldsen, Krzysztof Narkiewicz, Michel Burnier, Suzanne Oparil
No abstract text is available yet for this article.
August 2018: Blood Pressure
Radovan Prijić, Vedran Premužić, Marko Brinar, Željko Krznarić, Bojan Jelaković, Silvija Čuković-Čavka
PURPOSE: Chronic inflammatory diseases are related with earlier onset of atherosclerosis. We hypothesized that inflammatory bowel disease patients with chronic, systemic inflammation have an increased arterial stiffness associated with the disease duration. Also, we wanted to compare arterial stiffness markers between inflammatory bowel disease and well-controlled hypertension patients. MATERIALS AND METHODS: A total of 89 inflammatory bowel disease patients (60 patients with Crohn's disease and 29 patients with ulcerative colitis, age range 20-64 years) without history of arterial hypertension or diabetes were enrolled and age matched with a control group of patients (73 patients, age range 25-69 years, 41 (56...
August 2018: Blood Pressure
Gaia Favero, Anna Paini, Carolina De Ciuceis, Luigi F Rodella, Enrico Moretti, Enzo Porteri, Claudia Rossini, Silvia Ministrini, Leonardo Solaini, Caletti Stefano, Maria Antonietta Coschignano, Valeria Brami, Alina Petelca, Matteo Nardin, Ilenia Valli, Guido A M Tiberio, Francesca Bonomini, Claudia Agabiti Rosei, Nazario Portolani, Damiano Rizzoni, Rita Rezzani
BACKGROUND: In the development of hypertensive microvascular remodeling, a relevant role may be played by changes in extracellular matrix proteins. Aim of this study was the to evaluate some extracellular matrix components within the tunica media of subcutaneous small arteries in 9 normotensive subjects and 12 essential hypertensive patients, submitted to a biopsy of subcutaneous fat from the gluteal or the anterior abdominal region. PATIENTS AND METHODS: Subcutaneous small resistance arteries were dissected and mounted on an isometric myograph, and the tunica media to internal lumen ratio was measured...
August 2018: Blood Pressure
Yi-Bang Cheng, Qian-Hui Guo, Dong-Yan Zhang, Ying Wang, Qi-Fang Huang, Chang-Sheng Sheng, Ji-Guang Wang, Jan A Staessen, Yan Li
OBJECTIVE: Carotid-femoral pulse wave velocity (cfPWV) was associated with serum parathyroid hormone (PTH) in untreated Chinese. We investigated in the same cohort whether cfPWV, brachial-ankle (baPWV) and heart-brachial (hbPWV) pulse wave velocity (PWV) were associated with rs6127099 (CYP24A1) and rs4074995 (RGS14). A previously published genome-wide association study demonstrated that each additional copy of the T (rs6127099) or G (rs4074995) allele was associated with a 7% or 3% higher serum PTH, respectively...
August 2018: Blood Pressure
Jonas Wuopio, Carl Johan Östgren, Toste Länne, Lars Lind, Toralph Ruge, Axel C Carlsson, Anders Larsson, Fredrik H Nyström, Johan Ärnlöv
BACKGROUND: Endostatin, cleaved from collagen XVIII in the extracellular matrix, is a promising circulating biomarker for cardiovascular damage. It possesses anti-angiogenic and anti-fibrotic functions and has even been suggested to be involved in blood pressure regulation. Less is known if endostatin levels relate to circadian blood pressure patterns. In the present paper we studied the association between circulating levels of endostatin and nocturnal dipping in blood pressure. METHODS: We used the CARDIPP-study, a cohort of middle aged, type 2 diabetics (n = 593, 32% women), with data on both 24-hour and office blood pressure, serum-endostatin, cardiovascular risk factors, and incident major cardiovascular events...
August 2018: Blood Pressure
Culadeeban Ratneswaran, Martino F Pengo, Sichang Xiao, Yuanming Luo, Gian Paolo Rossi, Michael I Polkey, John Moxham, Joerg Steier
OBJECTIVES: Continuous positive airway pressure (CPAP) improves upper airway obstruction in patients with obstructive sleep apnoea (OSA), who often are overweight-obese. Although it is thought that CPAP improves long-term blood pressure control (BP), the impact of acute and short-term CPAP use on the cardiovascular system in obese patients has not been described in detail. METHODS: Obese patients (body mass index, BMI > 25 kg/m2 ) with OSA were studied awake, supine during incremental CPAP titration (4-20 cmH2 O, +2 cmH2 O/3 mins)...
August 2018: Blood Pressure
Giuseppe Maiolino, Giulio Ceolotto, Michele Battistel, Giulio Barbiero, Maurizio Cesari, Laurence Amar, Brasilina Caroccia, Roberto Padrini, Michel Azizi, Gian Paolo Rossi
PURPOSE: Aldosterone-producing adenoma (APA) is the main curable cause of endocrine hypertension cause of primary aldosteronism (PA) and it is in up to 66% of all cases investigated with adrenal vein sampling (AVS). Mutations in the KCNJ5 potassium channel involve up to 70% of APA and cause the most florid PA phenotypes. The recent finding that macrolide antibiotics specifically inhibit in vitro the altered function of mutated KCNJ5 channels has opened new horizons for the diagnosis and treatment of APA with KCNJ5 mutations in that it can allow identification and target treatment of PA patients harbouring a mutated APA...
August 2018: Blood Pressure
Elisabete Alves, Ana Rute Costa, Pedro Moura-Ferreira, Ana Azevedo, Nuno Lunet
PURPOSE: Adequate knowledge on hypertension has been shown to improve awareness, adherence to treatment and control of the disease. We aimed to estimate the health-related knowledge about hypertension among the Portuguese population. MATERIALS AND METHODS: A representative sample of Portuguese-speaking dwellers in mainland Portugal (n = 1624), aged 16 to 79 years, was evaluated through face-to-face interviews conducted using a structured questionnaire. Health literacy was evaluated using the instrument Newest Vital Sign...
August 2018: Blood Pressure
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