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Transfusion Medicine

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https://www.readbyqxmd.com/read/28643867/transfusion-transmitted-cmv-infection%C3%A2-%C3%A2-current-knowledge-and-future-perspectives
#1
REVIEW
M Ziemann, T Thiele
Transmission of human cytomegalovirus (CMV) via transfusion (TT-CMV) may still occur and remains a challenge in the treatment of immunocompromised CMV-seronegative patients, e.g. after stem cell transplantation, and for low birthweight infants. Measures to reduce the risk of TT-CMV have been evaluated in clinical studies, including leucocyte depletion of cellular blood products and/or the selection of CMV-IgG-negative donations. Studies in large blood donor cohorts indicate that donations from newly CMV-IgG-positive donors should bear the highest risk for transmitting CMV infections because they contain the highest levels of CMV-DNA, and early CMV antibodies cannot neutralise CMV...
June 23, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28621494/an-analysis-of-blood-donor-deferrals-among-repeat-donors
#2
LETTER
S Kheiri, Z Alibeigi
No abstract text is available yet for this article.
June 16, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28608636/aetiology-and-outcome-of-massive-transfusion-in-two-large-london-teaching-hospitals-over-a-3-year-period-2012-2014
#3
L Green, J Tan, C Grist, M Kaur, P MacCallum
OBJECTIVES: The objectives of this study were to determine: (i) the incidence of massive transfusion (MT) (defined as transfusion of ≥5 red-blood-cell (RBC) units within 4 h, and/or ≥10 RBC units within 24 h of bleeding) over a 3-year period; (ii) the cause, and mortality rate of patients who received MT (from any cause); and (iii) the risk factors for death. BACKGROUND: MT can occur in different clinical settings, yet little is known about its epidemiology/clinical outcomes...
June 13, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28608631/a-descriptive-single-centre-experience-of-the-management-and-outcome-of-maternal-alloantibodies-in-pregnancy
#4
V Chatziantoniou, N Heeney, T Maggs, C Rozette, C Fountain, T Watts, C Harrison, D Pasupathy, S Sankaran, P Kyle, S Robinson
BACKGROUND: Haemolytic disease of the fetus and newborn (HDFN) occurs when maternal IgG alloantibodies to fetal red blood cell antigens cross the placenta, causing haemolysis in the fetus and/or neonate. After delivery, the main concern is hyperbilirubinaemia, which can cause neurological damage. OBJECTIVES: To summarise our current management and outcome data to inform health-care professionals counselling women whose pregnancies are at risk of HDFN and to compare these data with relevant studies...
June 13, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28589653/assessment-of-hna-alloimmunisation-risk-in-northeastern-thais-burmese-and-karen
#5
P Simtong, C Puapairoj, C Leelayuwat, S Santoso, A V Romphruk
OBJECTIVES: This study aimed to determine human neutrophil antigen (HNA) frequency, estimate possible HNA incompatibilities and predict the risk of HNA alloimmunisation in the Northeastern Thai, Burmese and Karen populations. BACKGROUND: Alloantibodies against HNA are implicated in a number of clinical conditions, including immune-mediated neutropenia and transfusion reactions. METHODS: A total of 400 unrelated healthy Thais, 261 Burmese and 249 Karen was included in this study...
June 7, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28557101/the-association-between-interval-from-acceptance-to-first-time-donation-missed-first-appointment-and-future-donation-behaviour
#6
S A Mousavi, B Hermundstad, T R Knutsen, A H Llohn
BACKGROUND AND OBJECTIVES: We examined the association of the interval between the date an individual is accepted for blood donation and the date of first donation (IFD-interval, index-to-first-time donation interval) and missed first appointment with future donation behaviour among new donors. These two variables have not been analysed in previous studies of donation behaviour among new donors. METHODS: Categories were generated for age (18-29 vs 30-65 years), missed-appointment status (no-show vs same-day cancellation) and the IFD-interval [short (≤median time) vs long (>median time)]...
May 29, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28547759/blood-donors-attitudes-towards-voluntary-non-remunerated-donation-in-trinidad-and-tobago
#7
K S Charles, A Poon King, A Ramai, K Rajnath, D Ramkissoon, S Ramkissoon, C Ramlal, K Ramnarine, K Rampersad, G Legall, S Pooransingh, A D Chantry
OBJECTIVES: To assess the attitude towards voluntary non-remunerated blood donation among blood donors in Trinidad and Tobago (TRT). BACKGROUND: Blood donors in TRT are either family replacement (F/R, 87%) or remunerated (13%). There is chronic blood shortage and high seroreactivity for transfusion-transmissible infections (TTI) in donors. Converting existing to voluntary non-remunerated donors (VNRD) reduces the need to recruit news donors in achieving 100% VNRD...
May 26, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28543884/psychological-factors-related-to-donation-behaviour-among-chinese-adults-results-from-a-longitudinal-investigation
#8
H Hu, T Wang, Q Fu
BACKGROUND AND OBJECTIVES: Little is known about the psychological factors currently influencing blood donation in China. This study investigated the structure of psychological factors and their correlation with donation behaviour of adults in a transforming city in China over a 6-month period. METHODS: Participants were recruited in Nanjing from May 2013 to April 2014. Preliminary focus group interviews with 102 participants were conducted to generate new items for a Theory of Planned Behaviour (TPB) questionnaire...
May 22, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28524626/cardiac-arrest-triggered-by-hyperkalemia-during-red-blood-cell-transfusion-a-case-report-and-literature-review
#9
LETTER
Z Zhang, Y Shen, B Li, N Li
No abstract text is available yet for this article.
May 19, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28524621/a-fatal-case-of-autoanti-wr-b-causing-autoagglutination-of-red-blood-cells-and-intravascular-haemolysis
#10
LETTER
K Maguire, K Morris, M Quinn, B Herron, A Rainey, N Thornton
No abstract text is available yet for this article.
May 19, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28524547/performance-of-a-new-generation-continuous-autotransfusion-device-including-fat-removal-and-consequences-for-quality-controls
#11
T F Seyfried, M Gruber, D Bitzinger, M T Pawlik, A Breu, B M Graf, E Hansen
BACKGROUND AND OBJECTIVES: Cell salvage plays a key role in blood conservation. To maintain high performance, quality management is recommended. Accordingly, a new-generation autotransfusion device was tested for its performance and compared with its predecessor. Two different calculations of quality parameters were applied. MATERIALS AND METHODS: In an experimental study, the continuous autotransfusion devices CATSmart and Continuous Autotransfusion System (C.A...
May 19, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28524366/contrasting-hcv-and-hiv-seroepidemiology-in-11-years-of-blood-donors-screening-in-brazil
#12
J E Levi, S M Lira, C B Bub, M B Polite, C C Terzian, J M Kutner
BACKGROUND: Blood donors are, in principle, healthy individuals who may be revealed as infectious for blood-borne agents by the laboratory screening process, depicting the asymptomatic burden of the disease. Therefore, monitoring hepatitis C virus (HCV)-infected donor and human immunodeficiency virus (HIV)-infected donor and associating to their demographical and behavioural characteristics may shed light on the dynamics and contemporary changes in these viruses' epidemiology. METHODS: Donors presenting repeatedly reactive HCV or HIV serology/nucleic acid testing (NAT) screening results were submitted to confirmatory testing...
May 19, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28516675/analysis-of-platelet-reactive-alloantibodies-and-evaluation-of-cross-match-compatible-platelets-for-the-management-of-patients-with-transfusion-refractoriness
#13
J Wang, W Xia, J Deng, X Xu, Y Shao, H Ding, Y Chen, J Liu, D Chen, X Ye, S Santoso
BACKGROUND: Cross-match-compatible platelets can improve corrected count increments (CCIs) in alloimmunised patients with transfusion refractoriness. However, only a few studies mentioned that the specificities of platelet-reactive alloantibodies can predict high reactivity in cross-match assays among these patients. METHODS: A total of 204 medical records of patients who were refractory to random single-donor apheresis platelets between January 2014 and December 2014 were enrolled...
May 18, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28516464/the-blood-donation-ambivalence-survey-measuring-conflicting-attitudes-about-giving-blood
#14
K R Fox, L K Himawan, C R France
OBJECTIVES: This study was designed to develop and conduct initial validation testing for a novel measure of ambivalence about donating blood. BACKGROUND: Previous studies of living organ, bone marrow and stem cell donors have identified donation-related ambivalence as a predictor of decisions about donation and post-donation outcomes. Ambivalence about blood donation has not received the same attention. METHODS: In Study 1, a sample of young adults (N = 396) were administered test items of ambivalence, and exploratory (EFA) and confirmatory factor analyses (CFA) were performed to identify the Blood Donation Ambivalence Survey...
May 18, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28508562/can-serological-methods-help-distinguish-between-prophylactic-and-alloimmune-anti-d
#15
C Irving, M Crennan, T Vanniasinkam
OBJECTIVES: Enzyme indirect antiglobulin test (EIAT) and polyethylene glycol IAT (PIAT) were evaluated for their potential use as tests to distinguish between prophylactic and alloimmune anti-D in plasma by comparing with a tube variation of the standard low ionic strength solution-IAT (LISS-IAT). BACKGROUND: Laboratories performing the screening of RhD-negative pregnant women are required to provide clinicians with guidance as to the source of detected RhD antibodies...
May 15, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28470880/virus-inactivation-by-25-kgy-gamma-irradiation-during-a-new-manufacturing-process-of-%C3%AE-2-macroglobulin
#16
LETTER
C Huangfu, Y Ma, J Jia, M Lv, F Zhu, X Ma, X Zhao, J Zhang
No abstract text is available yet for this article.
May 4, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28419585/a-new-discrepancy-of-hpa-3-genotyping-because-of-a-rare-hpa-27bw-polymorphism
#17
LETTER
G Bertrand, A Aarnink, C Nivet, A Jacques, M Cherel, V Renac, A Kennel
No abstract text is available yet for this article.
April 17, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28401678/a-and-b-antigen-levels-acquired-by-group-o-donor-derived-erythrocytes-following-abo-non-identical-transfusion-or-minor-abo-incompatible-haematopoietic-stem-cell-transplantation
#18
A K Hult, J H Dykes, J R Storry, M L Olsson
BACKGROUND AND OBJECTIVES: ABO-incompatible haematopoietic stem cell transplantation (HSCT) presents a challenge to blood component transfusion. The aim of this study was to investigate the weak blood group A or B antigen expression by donor-derived group O red blood cells (RBC) observed following transfusion or minor ABO-incompatible HSCT. In addition, in vitro experiments were performed to elucidate possible mechanisms underlying this phenomenon. MATERIALS AND METHODS: A sensitive flow cytometry assay for the semi-quantification of RBC A/B antigen levels was used to assess patient samples and evaluate in vitro experiments...
April 12, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28401611/pegylated-bovine-carboxyhaemoglobin-utilisation-in-a-thrombotic-thrombocytopenic-purpura-patient
#19
C Sam, P Desai, D Laber, A Patel, N Visweshwar, M Jaglal
OBJECTIVE: To determine if pegylated bovine carboxyhaemoglobin can be utilised in a thrombotic thrombocytopenic purpura (TTP) patient. BACKGROUND: TTP is a condition characterized by thrombotic microangiopathy and has a high mortality rate when left untreated. Therapeutic plasma exchange is well established as the most effective and evidence-based treatment of TTP. METHODS: The ability to administer plasma exchange therapy is limited in Jehovah's Witnesses who decline blood products due to religious beliefs...
April 12, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28393455/hlamatchmaker-is-effective-for-selecting-appropriate-platelet-units-for-alloimmunised-thrombocytopaenic-patients-who-are-refractory-to-random-donor-platelets
#20
C O'Rafferty, G Rooney, R Hagan, M Woolfson, D O'Donghaile, J Fitzgerald
BACKGROUND: HLAMatchmaker has been used in the Irish Blood Transfusion Service (IBTS) to select platelets for HLA-alloimmunised, platelet refractory thrombocytopaenic patients since 2006. Although available since 2002, only three studies have been published supporting the programme's effectiveness for this indication. OBJECTIVES: We sought to examine increments to HLA-matched platelets (HMPs) at various matchmaker scores and to examine the impact of transfusing older platelets and ABO-mismatched platelets to this patient group...
April 10, 2017: Transfusion Medicine
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