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Transfusion Medicine

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https://www.readbyqxmd.com/read/29148259/vasovagal-reactions-in-blood-donors-risks-prevention-and-management
#1
REVIEW
A Thijsen, B Masser
This narrative review examines current research on risk factors, prevention methods and management strategies for vasovagal reactions (VVRs) that occur during or as a result of blood donation. VVRs are important to blood collection agencies (BCAs) as they negatively impact the number of completed collections, perceptions of the safety of blood donation and rates of donor return. There has been significant progress in understanding and preventing VVRs in blood donation in recent years, with a multitude of risk factors identified...
November 16, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/29148106/epidemiology-of-donors-and-recipients-lessons-from-the-scandat-database
#2
REVIEW
G Edgren, H Hjalgrim
With the development of several 'vein-to-vein' databases, which capture data on the entire donor-recipient continuum and link this data to health outcomes, there has been an increasing number of studies investigating the health effects of all aspects of the practice of transfusion medicine. The Scandinavian Donations and Transfusions (SCANDAT) database is one of several such databases, which includes all electronically available data on blood donors, donations and transfusions since the late 1960s in Sweden and the early 1980s in Denmark...
November 16, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/29110357/the-administration-of-blood-components-a-british-society-for-haematology-guideline
#3
S Robinson, A Harris, S Atkinson, C Atterbury, P Bolton-Maggs, C Elliott, T Hawkins, E Hazra, C Howell, H New, T Shackleton, K Shreeve, C Taylor
No abstract text is available yet for this article.
November 6, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/29067785/pre-hospital-transfusion-of-red-blood-cells-in-civilian-trauma-patients
#4
M Rehn, A E Weaver, S Eshelby, J Røislien, D J Lockey
INTRODUCTION: The current management of severely injured patients includes damage control resuscitation strategies that minimise the use of crystalloids and emphasise earlier transfusion of red blood cells (RBC) to prevent coagulopathy. In 2012, London's air ambulance (LAA) became the first UK civilian pre-hospital service to routinely carry RBC to the trauma scene. OBJECTIVE: To investigate the effect of pre-hospital RBC transfusion (phRTx) on overall blood product consumption...
October 24, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/29067784/interpretation-of-low-reactivity-in-the-abbott-architect-rhtlv-i-ii-assay
#5
J H C Tosswill, G P Taylor
OBJECTIVE: The objective of this study is to reduce donor tissue wastage. AIM: The aim of this study is to determine, in the case of the Abbott Architect rHTLV I/II assay, whether a signal/cut-off (S/CO) ratio higher than the manufacturer's recommendation of 1·0 could be applied to diagnose significant HTLV-1 seroreactivity. BACKGROUND: The detection of human T cell leukaemia virus type 1 (HTLV-1) infection is primarily based on serology often utilising random access platforms...
October 24, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/29058354/the-practice-of-diagnosing-and-reporting-transfusion-associated-circulatory-overload-a-national-survey-among-physicians-and-haemovigilance-officers
#6
J J Bosboom, R B Klanderman, A L Peters, E K van de Weerdt, E J Goudswaard, J M Binnekade, J J Zwaginga, E A M Beckers, B F Geerts, M W Hollmann, S S Zeerleder, M van Kraaij, A P Vlaar
OBJECTIVES: This study aims at identifying factors that disciplines consider when diagnosing and reporting transfusion-associated circulatory overload ('TACO'). BACKGROUND: TACO is a clinical diagnosis based mainly on subjective factors. Therefore, TACO could be an underreported complication of blood transfusion. METHODS: A survey was conducted among critical care physicians, anaesthesiologists, haematologists, transfusion medicine physicians and haemovigilance officers using case vignettes and a questionnaire...
October 23, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/29024104/the-healthy-donor-effect-impacts-self-reported-physical-and-mental-health%C3%A2-%C3%A2-results-from-the-danish-blood-donor-study-dbds
#7
A S Rigas, A Skytthe, C Erikstrup, K Rostgaard, M S Petersen, H Hjalgrim, H Ullum, K O Kyvik, O B Pedersen
AIMS: This study aimed at quantifying the healthy donor effect by comparing self-perceived mental and physical health between blood donors and non-donors. BACKGROUND: In theory, the selection process known as the healthy donor effect should result in better self-perceived, health-related quality of life in donors than in non-donors. METHODS: The Short Form-12 data from the Danish Twin Registry (DTR) was compared with the data from the Danish Blood Donor Study (DBDS)...
October 12, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/29024114/iron-deficiency-among-blood-donors-experience-from-the-danish-blood-donor-study-and-from-the-copenhagen-ferritin-monitoring-scheme
#8
REVIEW
A S Rigas, O B Pedersen, K Magnussen, C Erikstrup, H Ullum
Blood components collected from blood donors are an invaluable part of modern-day medicine. A healthy blood donor population is therefore of paramount importance. The results from the Danish Blood Donor Study (DBDS) indicate that gender, number of previous donations, time since last donation and menopausal status are the strongest predictors of iron deficiency. Only little information on the health effects of iron deficiency in blood donors exits. Possibly, after a standard full blood donation, a temporarily reduced physical performance for women is observed...
October 10, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28944508/blood-service-in-the-tibetan-regions-of-garz%C3%A3%C2%AA-and-aba-china-a-longitudinal-survey
#9
Y Wang, Z Wu, Y H Yin, S Q Rao, B Liu, X Q Huang, X X Liu, W H Li, S L Ye, S Y Li, X C Yu, D R Wu, J Xu, Z K Wang, R Zhang, C Q Li
BACKGROUND: Garzê and Aba form the second largest Tibetan-inhabited area of China. Blood services have never been reported for this region before. OBJECTIVE: To assess the current situation and analyse whether a safe and adequate blood supply has been developed in both Garzê and Aba. METHODS: We conducted a longitudinal survey covering the period 2011-2016. The subjects of interest were recruited from non-remunerated voluntary donation, blood testing, clinical transfusion practices and infrastructure of local blood service systems...
September 25, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28940786/cornerstones-of-patient-blood-management-in-surgery
#10
REVIEW
A Butcher, T Richards
Pre-operative anaemia and perioperative red blood cell transfusion carry significant consequence when it comes to surgical outcomes. The establishment of patient-centred clinical pathways has been designed to harness and endorse good transfusion practice, termed the three pillars of patient blood management (PBM). These focus on the timely and appropriate management of anaemia, prevention of blood loss and restrictive transfusion where appropriate. This article reviews the current evidence and ongoing research in the field of PBM in surgery...
September 22, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28940923/blood-conservation-in-cardiac-surgery
#11
REVIEW
G Blaudszun, A Butchart, A A Klein
This article aims at reviewing the currently available evidence about blood conservation strategies in cardiac surgery. Pre-operative anaemia and perioperative allogeneic blood transfusions are associated with worse outcomes after surgery. In addition, transfusions are a scarce and costly resource. As cardiac surgery accounts for a significant proportion of all blood products transfused, efforts should be made to decrease the risk of perioperative transfusion. Pre-operative strategies focus on the detection and treatment of anaemia...
September 21, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28940904/genotyping-of-the-abcg2-gene-using-matrix-associated-laser-desorption-ionisation-time-of-flight-mass-spectrometry
#12
M Tanaka, I Kamada, J Takahashi, T Kimura, Y Tani
OBJECTIVES: The aim of this study was to evaluate the applicability of genotyping of the ABCG2 gene using MALDI-TOF MS and to estimate the allele frequency in the Japanese population. BACKGROUND: Jr (a-) phenotype has a prevalence of approximately 0·05% among Japanese blood donors; DNA-based genotyping was conducted to investigate the molecular basis of the Jr (a-) phenotype along with serological typing. To detect all SNPs of the ABCG2 gene, a high-throughput SNP genotyping platform is needed...
September 21, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28913908/provision-of-cellular-blood-components-to-cmv-seronegative-patients-undergoing-allogeneic-stem-cell-transplantation-in-the-uk-survey-of-uk-transplant-centres
#13
S Morton, A Peniket, R Malladi, M F Murphy
OBJECTIVES: To identify current UK practice with regards to provision of blood components for cytomegalovirus (CMV)-seronegative, potential, allogeneic stem cell recipients of seronegative grafts. BACKGROUND: Infection with CMV remains a major cause of morbidity and mortality after allogeneic stem cell transplantation (aSCT). CMV transmission has been a risk associated with the transfusion of blood components from previously exposed donors, but leucocyte reduction has been demonstrated to minimise this risk...
September 15, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28913856/multiplate-and-teg-platelet-mapping-in-a-population-of-severely-injured-trauma-patients
#14
M J George, J Burchfield, B MacFarlane, Y-W W Wang, J C Cardenas, N J White, B S Gill, C E Wade
OBJECTIVES: The objectives of this study were to compare thromboelastography platelet mapping (TEG PM) with impedance aggregometry (Multiplate, MP) in a single trauma population and relate their results clinically. BACKGROUND: Platelet function as measured by thromboelastography and impedance aggregometry demonstrates significant reductions that persist for days following traumatic injury. However, no study compares these devices and the correlation between them is not known...
September 15, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28881103/hla-polymorphisms-and-risk-of-red-blood-cell-alloimmunisation-in-polytransfused-patients-with-sickle-cell-anaemia
#15
C Rodrigues, A M Sell, G A S Guelsin, T T Higa, S Pagliarini E Silva, L C Macedo, E Â Sippert, J B de Alencar, Â Zanette, C R L Acorsi, L Castilho, J E L Visentainer
BACKGROUND: Red blood cell (RBC) alloimmunisation is an event that may occur due to factors such as numerous blood transfusions, age, gender and genetic factors such as human leukocyte antigen (HLA). AIMS/OBJECTIVES: The aim of the present study was to investigate the possibility of alloimmunisation to red blood cell group antigens associated with the HLA of individuals and to relate alloimmunisation to risk factors. METHODS: A total of 172 polytransfused patients with sickle cell anaemia (SCA) (44 alloimmunised, 128 non-alloimmunised) participated in this study...
September 7, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28881066/molecular-screening-of-vel-blood-donors-using-dna-pools-in-nanjing-of-china
#16
LETTER
T X Liu, Y C Liu, L Ma, F Zhao, R Y Zhang, L L Shi
No abstract text is available yet for this article.
September 7, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28875563/theoretical-and-experimental-ethics-advocacy-for-blood-donors-and-beneficiaries-of-blood-transfusions
#17
LETTER
O Garraud, J-D Tissot
No abstract text is available yet for this article.
September 5, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28875548/bacterial-contamination-of-platelet-components-not-detected-by-bact-alert%C3%A2
#18
M A Abela, S Fenning, K A Maguire, K G Morris
OBJECTIVES: To investigate the possible causes for false negative results in BacT/ALERT® 3D Signature System despite bacterial contamination of platelet units. BACKGROUND: The Northern Ireland Blood Transfusion Service (NIBTS) routinely extends platelet component shelf life to 7 days. Components are sampled and screened for bacterial contamination using an automated microbial detection system, the BacT/ALERT® 3D Signature System. We report on three platelet components with confirmed bacterial contamination, which represent false negative BacT/ALERT® results and near-miss serious adverse events...
September 5, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28850748/sequence-analysis-of-abo-and-its-homologues-is-valid-for-species-identification
#19
R Sano, H Fukuda, Y Takahashi, K Takahashi, R Kubo, M Kobayashi, J Fujihara, H Takeshita, Y Kominato
BACKGROUND: ABO and its paralogues, such as A3GALT2 and GGTA1, encoding α1,3-Gal(NAc) transferases, belong to the glycosyltransferase 6 (GT6) gene family. We have developed an alternative method for the identification of species based on sequence variations within the GT6 gene family, which is applicable to degraded DNA. METHODS/MATERIALS: DNA samples prepared from control mammalian species, together with an unknown sample, were polymerase chain reaction (PCR)-amplified using one universal primer pair targeting the sequences in the last coding exons of the GT6 gene family, yielding 141-bp products derived from those multiple loci...
August 29, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/29076250/obituary-duncan-stephen-pepper-1942-2017
#20
A Farrugia
No abstract text is available yet for this article.
October 2017: Transfusion Medicine
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