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Transfusion Medicine

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https://www.readbyqxmd.com/read/28940786/cornerstones-of-patient-blood-management-in-surgery
#1
REVIEW
A Butcher, T Richards
Pre-operative anaemia and perioperative red blood cell transfusion carry significant consequence when it comes to surgical outcomes. The establishment of patient-centred clinical pathways has been designed to harness and endorse good transfusion practice, termed the three pillars of patient blood management (PBM). These focus on the timely and appropriate management of anaemia, prevention of blood loss and restrictive transfusion where appropriate. This article reviews the current evidence and ongoing research in the field of PBM in surgery...
September 22, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28940923/blood-conservation-in-cardiac-surgery
#2
REVIEW
G Blaudszun, A Butchart, A A Klein
This article aims at reviewing the currently available evidence about blood conservation strategies in cardiac surgery. Pre-operative anaemia and perioperative allogeneic blood transfusions are associated with worse outcomes after surgery. In addition, transfusions are a scarce and costly resource. As cardiac surgery accounts for a significant proportion of all blood products transfused, efforts should be made to decrease the risk of perioperative transfusion. Pre-operative strategies focus on the detection and treatment of anaemia...
September 21, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28940904/genotyping-of-the-abcg2-gene-using-matrix-associated-laser-desorption-ionisation-time-of-flight-mass-spectrometry
#3
M Tanaka, I Kamada, J Takahashi, T Kimura, Y Tani
OBJECTIVES: The aim of this study was to evaluate the applicability of genotyping of the ABCG2 gene using MALDI-TOF MS and to estimate the allele frequency in the Japanese population. BACKGROUND: Jr (a-) phenotype has a prevalence of approximately 0·05% among Japanese blood donors; DNA-based genotyping was conducted to investigate the molecular basis of the Jr (a-) phenotype along with serological typing. To detect all SNPs of the ABCG2 gene, a high-throughput SNP genotyping platform is needed...
September 21, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28913908/provision-of-cellular-blood-components-to-cmv-seronegative-patients-undergoing-allogeneic-stem-cell-transplantation-in-the-uk-survey-of-uk-transplant-centres
#4
S Morton, A Peniket, R Malladi, M F Murphy
OBJECTIVES: To identify current UK practice with regards to provision of blood components for cytomegalovirus (CMV)-seronegative, potential, allogeneic stem cell recipients of seronegative grafts. BACKGROUND: Infection with CMV remains a major cause of morbidity and mortality after allogeneic stem cell transplantation (aSCT). CMV transmission has been a risk associated with the transfusion of blood components from previously exposed donors, but leucocyte reduction has been demonstrated to minimise this risk...
September 15, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28913856/multiplate-and-teg-platelet-mapping-in-a-population-of-severely-injured-trauma-patients
#5
M J George, J Burchfield, B MacFarlane, Y-W W Wang, J C Cardenas, N J White, B S Gill, C E Wade
OBJECTIVES: The objectives of this study were to compare thromboelastography platelet mapping (TEG PM) with impedance aggregometry (Multiplate, MP) in a single trauma population and relate their results clinically. BACKGROUND: Platelet function as measured by thromboelastography and impedance aggregometry demonstrates significant reductions that persist for days following traumatic injury. However, no study compares these devices and the correlation between them is not known...
September 15, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28881103/hla-polymorphisms-and-risk-of-red-blood-cell-alloimmunisation-in-polytransfused-patients-with-sickle-cell-anaemia
#6
C Rodrigues, A M Sell, G A S Guelsin, T T Higa, S Pagliarini E Silva, L C Macedo, E Â Sippert, J B de Alencar, Â Zanette, C R L Acorsi, L Castilho, J E L Visentainer
BACKGROUND: Red blood cell (RBC) alloimmunisation is an event that may occur due to factors such as numerous blood transfusions, age, gender and genetic factors such as human leukocyte antigen (HLA). AIMS/OBJECTIVES: The aim of the present study was to investigate the possibility of alloimmunisation to red blood cell group antigens associated with the HLA of individuals and to relate alloimmunisation to risk factors. METHODS: A total of 172 polytransfused patients with sickle cell anaemia (SCA) (44 alloimmunised, 128 non-alloimmunised) participated in this study...
September 7, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28881066/molecular-screening-of-vel-blood-donors-using-dna-pools-in-nanjing-of-china
#7
LETTER
T X Liu, Y C Liu, L Ma, F Zhao, R Y Zhang, L L Shi
No abstract text is available yet for this article.
September 7, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28875563/theoretical-and-experimental-ethics-advocacy-for-blood-donors-and-beneficiaries-of-blood-transfusions
#8
LETTER
O Garraud, J-D Tissot
No abstract text is available yet for this article.
September 5, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28875548/bacterial-contamination-of-platelet-components-not-detected-by-bact-alert%C3%A2
#9
M A Abela, S Fenning, K A Maguire, K G Morris
OBJECTIVES: To investigate the possible causes for false negative results in BacT/ALERT® 3D Signature System despite bacterial contamination of platelet units. BACKGROUND: The Northern Ireland Blood Transfusion Service (NIBTS) routinely extends platelet component shelf life to 7 days. Components are sampled and screened for bacterial contamination using an automated microbial detection system, the BacT/ALERT® 3D Signature System. We report on three platelet components with confirmed bacterial contamination, which represent false negative BacT/ALERT® results and near-miss serious adverse events...
September 5, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28875531/pathogen-reduction-of-whole-blood-utility-and-feasibility
#10
REVIEW
J-P Allain, R Goodrich
OBJECTIVES: To collect information on pathogen reduction applied to whole blood. BACKGROUND: Pathogen reduction (PR) of blood components has been developed over the past two decades, and pathogen-reduced fresh-frozen plasma and platelet concentrates are currently in clinical use. High cost and incomplete coverage of components make PR out of reach for low- and middle-income countries (LMIC). However, should PR become applicable to whole blood (WB), the main product transfused in sub-Saharan Africa, and be compatible with the preparation of clinically suitable components, cost would be minimised, and a range of safety measures in place at high cost in developed areas would become redundant...
September 5, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28850748/sequence-analysis-of-abo-and-its-homologues-is-valid-for-species-identification
#11
R Sano, H Fukuda, Y Takahashi, K Takahashi, R Kubo, M Kobayashi, J Fujihara, H Takeshita, Y Kominato
BACKGROUND: ABO and its paralogues, such as A3GALT2 and GGTA1, encoding α1,3-Gal(NAc) transferases, belong to the glycosyltransferase 6 (GT6) gene family. We have developed an alternative method for the identification of species based on sequence variations within the GT6 gene family, which is applicable to degraded DNA. METHODS/MATERIALS: DNA samples prepared from control mammalian species, together with an unknown sample, were polymerase chain reaction (PCR)-amplified using one universal primer pair targeting the sequences in the last coding exons of the GT6 gene family, yielding 141-bp products derived from those multiple loci...
August 29, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28833768/metastatic-efficiency-of-tumour-cells-can-be-impaired-by-intraoperative-cell-salvage-process-truth-or-conjecture
#12
REVIEW
N Kumar, A S Zaw, S B Kantharajanna, B L Khoo, C T Lim, J P Thiery
The use of salvaged blood in oncological surgery has been a matter of controversy over the years. This is due to the concern of systemic dissemination of reinfused tumour cells. Recent literature, across disciplines, has shed considerable light on its safety in terms of tumour recurrence, progression and overall survival rates. This clinical safety demonstrates the apparent metastatic inefficiency of reinfused tumour cells. The proof of this concept comes from various studies that have shown that salvaged blood has no tumour cells, or has a significantly lower count as compared to the patient's original circulatory tumour load...
August 23, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28833874/use-of-granulocyte-transfusions-among-haematology-units-in-england-and-north-wales
#13
S Morton, A Mijovic, D I Marks, J Griffin, E Massey, N Bhatnagar, S J Stanworth
OBJECTIVES: To establish the current use of granulocyte transfusions in haematology patients and explore interest in further research. BACKGROUND: Granulocytes may be used for the treatment of severe infection in neutropenic patients or for primary or secondary prophylaxis. Clinical utility of granulocyte transfusions is unclear, and recent studies have demonstrated equivocal outcomes. Pooled granulocytes are the main granulocyte product used in England and Wales, but there are no data on the patterns of use and little consensus on accepted indications...
August 18, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28833743/paroxysmal-nocturnal-haemoglobinuria-testing-in-blood-transfusion-laboratories-do-they-go-with-the-flow
#14
L Whitby, J White, M Fletcher, A Whitby, C Milkins, D Barnett
Paroxysmal nocturnal haemoglobinuria (PNH) is a rare stem cell disorder causing, in untreated patients, symptoms that include renal damage, thrombosis and increased mortality. When correctly diagnosed and treated, patients have reduced symptoms and normal life expectancies. Historically PNH testing resided within blood transfusion laboratories using techniques that were insensitive, for example, the Ham test. However, technology has evolved and flow cytometry is now regarded as the gold standard methodology...
August 18, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28804958/prevalence-of-hepatitis-b-and-human-t-lymphotropic-virus-infection-among-blood-donors-at-a-hospital-in-the-south-central-highlands-of-peru
#15
LETTER
M C Ramírez-Soto, M Huichi-Atamari
No abstract text is available yet for this article.
August 14, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28786224/motivational-factors-for-blood-donation-in-first-time-donors-and-repeat-donors-a-cross-sectional-study-in-west-pomerania
#16
A Suemnig, U Konerding, G Hron, N Lubenow, U Alpen, W Hoffmann, T Kohlmann, A Greinacher
OBJECTIVES: This study aimed to analyse motivational factors for blood donation in different donor groups. BACKGROUND: As the demographic change will result in a decrease of the population in age groups of blood donors, the risk of blood product shortage increases. METHODS: During a 12-month period, every sixth blood donor presenting at the blood donation centre of the University Hospital was asked to complete a self-administered questionnaire assessing motivational factors for blood donation...
August 7, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28758700/dengue-virus-infections-among-blood-donors-in-guangxi-of-china-2013-2014
#17
Z Gao, Y Zhang, Y Yang, M Xu, P Liao, W He, J Xu, Y Liu, M He
BACKGROUND: An unexpected, large dengue outbreak, spreading to 20 cities of Guangdong province, occurred in July 2014. Considering the overwhelming influence of this seasonal epidemic, whether this dengue virus outbreak has an significant impact on the blood donors of the ajacent areas in Guangdong requires at least a preliminary investigation. Liuzhou City of Guangxi was chosen as a good representative of the neighbouring geographical location of the dengue virus (DENV) outbreak areas in this research...
July 31, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28749037/transfusion-for-sickle-cell-disease-in-pregnancy-a-single-centre-survey
#18
J Sharif, L Byrd, K Stevenson, J Raddats, E Morsman, K Ryan
INTRODUCTION: Sickle cell disease in pregnancy carries a high risk of maternal and fetal adverse outcomes. The use of prophylactic transfusions to reduce the risk of sickle complications is controversial. Current UK standards do not recommend the routine use of transfusion for sickle pregnancy. We examined transfusion episodes during sickle pregnancies in a single centre over an 11-year period. METHODS: We conducted a retrospective observational study of all pregnancies in patients with sickle cell disease who attended the joint obstetric/haematology clinic over an 11-year period...
July 27, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28737229/advances-in-transfusion-medicine-gastrointestinal-bleeding
#19
REVIEW
K Oakland, V Jairath, M F Murphy
Gastrointestinal bleeding is a common medical and surgical emergency and is the second most common indication for red blood cell (RBC) transfusion in the UK. Most transfusion guidelines recommend the use of restrictive blood transfusion in stable gastrointestinal bleeding. This review explores the evidence supporting this practice, including whether it is safe in lower as well as upper gastrointestinal bleeding, and the risks of restrictive transfusion in patients with cardiovascular disease. There is a lack of evidence supporting the use of platelet and fresh frozen plasma transfusion in gastrointestinal bleeding...
July 24, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28722278/non-physician-health-care-workers-and-voluntary-blood-donation-an-ambiguous-relationship
#20
N Sousos, S Sfyridou, D Adamidou, T-A Vyzantiadis, M Karadosidou, A Filippou, T Karafoulidou, M Chouridi, S Theodoridou
OBJECTIVES: This study aims to assess the knowledge, attitude and practice (KAP) of voluntary blood donation (BD) among the non-physician health-care workers of our institution, to investigate the relationship between these parameters and to determine the predictors of BD practice. BACKGROUND: KAP surveys provide a popular context-specific evidence base for the development of blood transfusion services' strategies and interventions to promote voluntary, non-remunerated BD...
July 19, 2017: Transfusion Medicine
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