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Journal of Glaucoma

Keunheung Park, Jinmi Kim, Jiwoong Lee
PURPOSE: To evaluate the relationship between macular vessel density and ganglion cell to inner plexiform layer thickness (GCIPLT) and to compare their diagnostic performance. We attempted to develop a new combined parameter using an artificial neural network. METHODS: A total of 173 subjects: 100 for the test and 73 for neural net training. The test group consisted of 32 healthy, 33 early, and 35 advanced glaucoma subjects. Macular GCIPLT and vessel density were measured using Spectralis optical coherence tomography (OCT) and Topcon swept-source OCT, respectively...
July 12, 2018: Journal of Glaucoma
Anthony P Khawaja, Michelle P Y Chan, Jennifer L Y Yip, David C Broadway, David F Garway-Heath, Ananth C Viswanathan, Robert Luben, Shabina Hayat, Michael A Hauser, Nicholas J Wareham, Kay-Tee Khaw, Brad Fortune, R Rand Allingham, Paul J Foster
PURPOSE: A common missense variant in the SIX6 gene (rs33912345) is strongly associated with primary open-angle glaucoma (POAG). We aimed to examine the association of rs33912345 with optic disc and retinal nerve fiber layer (RNFL) measures in a European population. METHODS: We examined participants of the population-based EPIC-Norfolk Eye Study. Participants underwent confocal laser scanning tomography (Heidelberg Retina Tomograph II, HRT) to estimate optic disc rim area and vertical cup-disc ratio (VCDR)...
July 12, 2018: Journal of Glaucoma
Hellen C S Römkens, Henny J M Beckers, Jan S A G Schouten, Rudy M M A Nuijts, Tos T J M Berendschot, Christophe M Breusegem, Carroll A B Webers
PURPOSE: The purpose of this study is to evaluate the effect of early phacoemulsification on the management of acute angle closure glaucoma in patients with coexisting cataract after initial treatment with medical therapy and laser peripheral iridotomy. PATIENTS AND METHODS: This study involved a retrospective analysis of patients presenting to the Maastricht University Medical Center+ with acute angle closure and coexisting cataract between 2005 and 2015. Patients were included after initial treatment with a standard protocol comprising topical and systemic medical therapy and laser peripheral iridotomy...
July 12, 2018: Journal of Glaucoma
Stephanie L Grillo, Christa L Montgomery, Heather M Johnson, Peter Koulen
PURPOSE: We investigated the relationship between visual parameters that are commonly affected during glaucomatous disease progression with functional measures of retina physiology using electroretinography and behavioral measures of visual function in a mouse model of glaucoma. Electroretinogram components measuring retinal ganglion cell (RGC) responses were determined using the non-invasive Ganzfeld flash electroretinography (fERG) in order to assess RGC loss in a mouse model of glaucoma...
July 11, 2018: Journal of Glaucoma
Janusz Skrzypecki, Tymoteusz Żera, Marcin Ufnal
BACKGROUND: Accumulating evidence supports a role of gut bacterial metabolites in arterial blood pressure (BP) regulation. Since the mechanisms controlling intraocular pressure (IOP) and BP overlap, we hypothesized that butyrate, a bacterial metabolite, might affect both IOP and BP. METHODS: IOP, BP and heart rate (HR) were measured at baseline and after the intraperitoneal administration of either butyrate or a vehicle (0.9% NaCl) in anaesthetized normotensive Wistar-Kyoto rats (WKY) and Spontaneously Hypertensive rats (SHR)...
July 11, 2018: Journal of Glaucoma
Michael L Hopen, Shamil Patel, Mark J Gallardo
PURPOSE: To report a case of successful intraocular pressure reduction following CyPass supraciliary stent implantation in a post-vitrectomized eye filled with silicone oil and chronic angle closure glaucoma. METHODS AND MATERIALS: Case report RESULTS:: A 19 year-old female with chronic angle closure glaucoma underwent combined cataract extraction, goniosynechiolysis and CyPass supraciliary shunt implantation. Patient had a history of proliferative diabetic retinopathy and a tractional retinal detachment, which required pars plana vitretomy and silicone oil implantation, and was subsequently complicated by neovascular glaucoma requiring implantation of an inferior glaucoma drainage device...
July 3, 2018: Journal of Glaucoma
Juha Välimäki
PURPOSE: To describe a new surgical method for treating late profound hypotony in two patients with glaucoma drainage implant (GDI). PATIENTS AND METHODS: Two patients, an 85-year-old woman and a 44-year-old woman, presented with choroidal effusions secondary related to chronic hypotony after GDI surgery. A novel technique was performed in both cases in order to narrow the lumen size of the GDI tube. The GDI tube was exposed and ligated temporarily with a polyglactin suture in both cases...
July 3, 2018: Journal of Glaucoma
Aleksandr Yelenskiy, Thomas B Gillette, Analisa Arosemena, Augustus G Stern, Winston J Garris, Curt T Young, Michelle Hoyt, Nancy Worley, David Zurakowski, Ramesh S Ayyala
PURPOSE: To report the safety and efficacy outcomes following micropulse transscleral cyclophotocoagulation (MPTSCPC) procedure in patients with uncontrolled glaucoma. METHODS: Longitudinal retrospective cohort, multicenter study. Patients with different types of glaucoma who underwent MPTSCPC with P3 probe between July 2015 and May 2017. Patients were treated by different glaucoma specialists from 5 different locations (Tulane Study Group). Data on preoperative characteristics, surgical procedure(s) performed and postoperative outcomes were collected and analyzed...
July 3, 2018: Journal of Glaucoma
Phillip M Radke, Tal Rubinstein, Steven Hamilton, Annisa Jamil, Bryan S Sires
INTRODUCTION: Trans-lamina cribrosa pressure has been postulated to be a contributor in the development of a glaucomatous optic nerve versus optic nerve edema, depending on the pressure gradient. Uncertainty remains in the therapeutic outcome of adjusting this gradient. CASE REPORT: We discuss a unique case of idiopathic intracranial hypertension presenting as asymmetric optic disc edema following trabeculectomy. It was treated via optic nerve fenestration due to the patient remaining symptomatic on maximum tolerated acetazolamide...
July 3, 2018: Journal of Glaucoma
Lauriane Salinas, Ankita Chaudhary, John P Berdahl, Gabriel S Lazcano-Gomez, Blake K Williamson, Syril K Dorairaj, Leonard K Seibold, Sanjay Smith, Ahmad A Aref, Jason K Darlington, Jesus Jimenez-Roman, Ahad Mahootchi, Mohamed Boucekine, Kaweh Mansouri
PURPOSE: To describe short-term efficacy and safety of goniotomy with trabecular meshwork excision using the Kahook Dual Blade (KDB, New World Medical Inc., Rancho Cucamonga, CA) in patients with severe or refractory glaucoma. METHOD: Retrospective multicentric case series of 53 eyes with severe or refractory glaucoma as defined by ICD-10 conducted in the United States, Mexico and Switzerland. Primary efficacy outcome was a 20% or more decrease in intraocular pressure (IOP) from baseline at 6 months...
July 3, 2018: Journal of Glaucoma
Gloria Liliana Duque-Chica, Carolina P B Gracitelli, Ana Laura Araujo Moura, Balázs Vince Nagy, Kallene Summer Vidal, Augusto Paranhos, Dora Fix Ventura
PURPOSE: To evaluate in patients with Primary Open Angle Glaucoma (POAG) the contribution of the inner and outer retinal photoreceptors to the pupillary light responses (PLRs) correlated with both functional (color vision and visual field (VF) perimetry) and morphological (optical coherence tomography-OCT) parameters. METHODS: Forty-five patients with POAG and 25 healthy control participants were evaluated. The PLR was measured as pupil diameter with an eye tracker; stimuli were presented in a Ganzfeld...
June 29, 2018: Journal of Glaucoma
Tony Realini, Hazel Shillingford-Ricketts, Darra Burt, Goundappa K Balasubramani
PURPOSE: To identify factors associated with intraocular pressure (IOP) reduction following selective laser trabeculoplasty (SLT) in Afro-Caribbean people with primary open-angle glaucoma (POAG). DESIGN: Prospective stepped-wedge study. METHODS: Data were drawn from 72 Afro-Caribbean subjects with primary open-angle glaucoma participating in the ongoing West Indies Glaucoma Laser Study (WIGLS). Multivariable mixed-model analysis was utilized to develop a predictive model for percent IOP reduction 12 months following SLT...
June 29, 2018: Journal of Glaucoma
Xinjun Li, Jan Sundquist, Bengt Zöller, Kristina Sundquist
BACKGROUND: Glaucoma has a familial component but detailed data on the modification of familial risks are lacking. The aim of the study was to determine detailed familial risks for medically diagnosed glaucoma based on nationwide hospital and population records. METHODS: Subjects were obtained from the Multigeneration Register, contains the Swedish population in families, and glaucoma patients were identified from the Hospital Discharge Register (1987-2012) and the Outpatient Register (2001-2012)...
June 26, 2018: Journal of Glaucoma
Ken Asakawa, Mami Nanno, Hitoshi Ishikawa, Nobuyuki Shoji
PURPOSE: To evaluate the accuracy of pupil fields and determine the normative pupillary response data by age using a newly developed head-mounted perimeter. METHODS: A total of 100 healthy subjects (20-68▒y of age) were enrolled. The newly developed head-mounted perimeter "imo" was used to measure the percentage pupil constriction (PPC) as response to a stimulus at all 36 test points of the visual field. Goldmann size III and V stimuli at 0, 8, and 11 decibels (dB) under 31...
June 26, 2018: Journal of Glaucoma
Bhavani Karri, Chandni Gupta, Divya Mathews
BACKROUND: XEN45® Gel stents(Allergan inc. Dublin, Ireland) are in their infancy and clinical expertise with microsurgical glaucoma devices are increasing. The soft flexible nature of the XEN stent together with its malleability under the conjunctival tissue should negate any risk of exposure of the XEN45 stent(XEN). However we report a case in which, sight threatening endophthalmitis was the presenting feature of this complication. CASE REPORT: We present a case of uncomplicated XEN implantation that developed endophthalmitis 4 months after surgery...
June 26, 2018: Journal of Glaucoma
Qian Wang, Weiwei Chen, Xiaoxia Qu, Huaizhou Wang, Ying Wang, Xun Zhang, Ting Li, Ningli Wang, Junfang Xian
PURPOSE: Altered ocular and cerebral vascular autoregulation and vasoreactivity have been demonstrated in patients with primary open-angle glaucoma (POAG). In the present study, we investigated the correlations between reduced cerebral blood flow (CBF) in early and higher-tier visual cortical areas and glaucomatous changes in the retinas of patients with mild to moderate POAG. PATIENTS AND METHODS: 3D pseudo-continuous arterial spin labelling (ASL) magnetic resonance imaging (MRI) at 3T was performed in twenty normal controls and fifteen mild to moderate POAG patients...
June 26, 2018: Journal of Glaucoma
Parul Ichhpujani, Sahil Thakur, Suresh Kumar, Rohan Bir Singh
INTRODUCTION: Glaucoma in patients with Non Bullous Congenital Ichthyosiform Erythroderma (NBCIE) is a rare entity that has not been described in a histologically confirmed case. We present a unique case of coexisting glaucoma, ichthyosis and dwarfism that has not been previously described. METHODS: We present a case of NBCIE with glaucoma and dwarfism that presented to our outpatient department. The patient was referred for watering and photophobia that were due to an epithelial defect that was subsequently managed conservatively...
June 26, 2018: Journal of Glaucoma
João Barbosa-Breda, Manuel Gonçalves-Pinho, João Vasco Santos, Amândio Rocha-Sousa, Luís Abegão-Pinto, Ingeborg Stalmans, Alberto Freitas
PURPOSE: Glaucoma leads as the first cause of irreversible blindness. The number of patients will greatly increase in upcoming years and changes will have to be done to cope with those numbers. As such, data are important to understand the effect of new policies introduced in glaucoma management. Only few countries have described their glaucoma surgical profile and, in Europe, only the United Kingdom described the last 15 years. The aim of this study is to assess the glaucoma surgical profile and its changes in mainland Portugal from 2000 to 2015...
June 26, 2018: Journal of Glaucoma
Koosha Ramezani, Iván Marín-Franch, Rongrong Hu, William H Swanson, Lyne Racette
PURPOSE: The purpose of this study was to determine whether combining a structural measure with contrast sensitivity perimetry (CSP), which has lower test-retest variability than static automated perimetry (SAP), reduces prediction error with two models of glaucoma progression. METHODS: In this retrospective analysis, eyes with 5 visits with rim area (RA), SAP and CSP measures were selected from two datasets. Twenty-six eyes with open-angle glaucoma were included in the analyses...
June 18, 2018: Journal of Glaucoma
Donald C Hood, Carlos G De Moraes
We pose four questions for the clinician diagnosing and monitoring glaucoma, and supply evidence-based answers. The first question is: "When do you perform a 10-2 (2° grid) visual field test?" We argue the best answer is: anyone you would do, or have done, a 24-2 (6° grid) visual field on should have both a 24-2 and a 10-2 visual field within the first two visits. Second, "When do you perform an optical coherence tomography (OCT) scan of the macula?" We argue that, if you are performing an OCT test, then it should include both the macula and disc, either as a single scan or as two scans, one centered on the macula and the other on the disc...
June 18, 2018: Journal of Glaucoma
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