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Journal of Glaucoma

Mohammad H Ahoor, Amir Ghorbanihaghjo, Rana Sorkhabi, Ali Kiavar
PURPOSE: Klotho is a newly discovered protein that presumably has an important role in the aging process. The goal of this research is to compare the levels of Klotho and Endothelin-1 (ET-1) in the serum and aqueous humor of patients with pseudoexfoliation syndrome (PES) and pseudoexfoliative glaucoma (PEG). PATIENTS AND METHODS: Aqueous humor and serum samples were obtained at the time of cataract surgery from 15 patients with PES, 15 patients with PEG, and 15 control patients...
October 14, 2016: Journal of Glaucoma
Mark Yu-Ming Chiang, Jayne E Camuglia, Peng Tee Khaw
PURPOSE: To describe a new and simple technique of glaucoma tube extension that carries several advantages over previously described techniques. PATIENTS AND METHODS: A retrospective noncomparative case series of 3 patients (1 adult and 2 pediatric cases) with glaucoma tube retraction managed by the "tube-in-tube" technique. The follow-up duration ranges from 1 month to 3 years. RESULTS: Adequate tube position and length were seen in all cases throughout the follow-up period...
October 14, 2016: Journal of Glaucoma
Nikhil S Choudhari, Harsha L Rao, Suresh Ramavath, Gunturu Rekha, Aparna Rao, Sirisha Senthil, Chandra S Garudadri
PURPOSE: To evaluate the frequency of Goldmann applanation tonometer (GAT) calibration error (CE) check. METHODS: One observer at each of the 3 tertiary care ophthalmic centers was involved. The tonometers were checked at baseline for CE. A tonometer was defined as faulty when CE exceeded 2 mm Hg at any testing level. Faulty GATs were repaired in-house. Subsequent CE check was done once per month for 6 months. GATs were divided into 3 groups: group 1 (G1)≤1 year, group 2 (G2)>1 to 10 years, and group 3 (G3)>10 years of usage...
October 14, 2016: Journal of Glaucoma
Cindy T Y Lam, Graham E Trope, Yvonne M Buys
PURPOSE: To measure the influence of body weight on postural intraocular pressure (IOP) changes and to determine if significant weight loss effects IOP. PATIENTS AND METHODS: In this prospective case-control study 25 morbidly obese subjects scheduled for bariatric surgery and 25 age-matched and sex-matched normal weight controls were recruited. Subjects had tonometry performed in 7 positions with the order randomized: sitting with the neck in neutral position, neck flexion at 30 degrees, extension at 30 degrees, supine, right, and left lateral decubitus, and with the head and upper body elevated at 30 degrees...
October 14, 2016: Journal of Glaucoma
Youngkyo Kwun, Gyule Han, Yoon-Jung Choy, Jong Chul Han, Changwon Kee
PURPOSE OF THE STUDY: The purpose of the study was to evaluate the optic disc characteristics associated with visual field (VF) progression in normal tension glaucoma (NTG) eyes with tilted optic discs. METHODS: Sixty-six eyes of 66 NTG patients with tilted optic disc were included in this cross-sectional study, who were examined by at least 5 Humphrey 30-2 VFs. Glaucomatous VF progression was evaluated using pointwise linear regression. Optic nerve heads were scanned with enhanced-depth imaging optical coherence tomography (EDI-OCT), and evaluated for the focal lamina cribrosa (LC) defects and LC thicknesses...
October 14, 2016: Journal of Glaucoma
Davinder S Grover, David G Godfrey, Oluwatosin Smith, Wei Shi, William J Feuer, Ronald L Fellman
PURPOSE: To report on outcomes of gonioscopy-assisted transluminal trabeculotomy (GATT) in eyes with prior incisional glaucoma surgery. PATIENTS AND METHODS: A retrospective review was performed for all patients who underwent a GATT procedure with a history of prior incisional glaucoma surgery. RESULTS: Thirty-five eyes of 35 patients were treated. The mean age was 67.7 years. Nineteen eyes had a prior trabeculectomy, 13 eyes had a prior glaucoma drainage device, 4 eyes had a prior trabectome, and 5 eyes had prior endocyclophotocoagulation...
October 6, 2016: Journal of Glaucoma
Takehiro Yamashita, Taiji Sakamoto, Naoya Yoshihara, Hiroto Terasaki, Minoru Tanaka, Yuya Kii, Kumiko Nakao
PURPOSE: To determine the correlations between the retinal nerve fiber layer thickness (RNFLT) and the axial length, peripapillary retinal tilt (PRT), and optic disc size, and retinal artery position. METHODS: A prospective, observational cross-sectional study of 119 healthy right eyes of 119 volunteers. All participants underwent comprehensive ophthalmologic examinations including peripapillary RNFLT imaging and measurements of the axial length. The RNFLT was determined by the TOPCON 3D OCT-1000, MARK II...
October 6, 2016: Journal of Glaucoma
Mahmut Asfuroglu, Busranur Cavdarli, Ozlem G Koz, Ahmet A Yarangumeli, Emine Y Ozdemir
PURPOSE: To investigate the genetic association of lysyl oxidase-like 1 (LOXL1) gene polymorphisms in patients with pseudoexfoliation (PEX) syndrome and PEX glaucoma of Turkish descent. METHODS: Three LOXL1 single nucleotide polymorphisms (SNPs) (rs1048661, rs3825942, and rs2165241) were analyzed in 109 Turkish patients (44 patients with PEX syndrome, 65 patients with PEX glaucoma) and 47 healthy subjects. RESULTS: "A" allele of SNP rs3825942 was underrepresented in control group compared with the glaucoma [odds ratio (OR)=4...
October 6, 2016: Journal of Glaucoma
Elisa D'Alessandro, Jacopo M Guidotti, Kaweh Mansouri, André Mermoud
BACKGROUND: Glaucoma drainage devices have traditionally been reserved for patients with refractory glaucoma. However, these devices are prone to various sight-threatening complications. To prevent hypotony after placement of the Baerveldt tube, surgeons traditionally tie the tube with an absorbable suture until encapsulation occurs around the plate. We hypothesized that combining the XEN tube, placing it in the anterior chamber and connecting it to the Baerveldt tube posteriorly, outside the anterior chamber, would minimize 2 main potentially blinding complications: hypotony and corneal disease...
September 21, 2016: Journal of Glaucoma
Bo Hee Kim, Eun Ji Lee
PURPOSE OF THE STUDY: The purpose of the study was to report cases with acute primary angle closure where optic disc swelling was documented after intraocular pressure (IOP) lowering by laser iridotomy. PATIENTS AND METHODS: Two patients with acute primary angle closure underwent funduscopic examination of the optic disc and spectral-domain optical coherence tomography circumpapillary scanning at the time of acute primary angle closure attack before laser iridotomy, and after the laser iridotomy treatment...
September 21, 2016: Journal of Glaucoma
Hiroshi Inazaki, Satoshi Kobayashi, Yoko Anzai, Hisayoshi Satoh, Shimpei Sato, Maiko Inoue, Shin Yamane, Kazuaki Kadonosono
PURPOSE OF THE STUDY: The purpose of the study was to evaluate the intraocular pressure (IOP)-lowering effect and tolerability of ripasudil, a rho-kinase inhibitor, in patients with glaucoma inadequately controlled with maximum medical therapy. PATIENTS AND METHODS: This prospective, noncomparative, interventional case series study included 35 patients with primary open angle glaucoma, in whom the glaucoma was poorly controlled with maximum medical therapy before starting the treatment with ripasudil...
September 21, 2016: Journal of Glaucoma
Carmen Mendez-Hernandez, Paula Arribas-Pardo, Ricardo Cuiña-Sardiña, Cristina Fernandez-Perez, Rosalia Mendez-Fernandez, Federico Saenz-Frances, Jose M Benitez-Del-Castillo, Julian Garcia-Feijoo
PURPOSE: To compare intraocular pressure (IOP) measurements made using 5 tonometers in keratoconic eyes with and without intrastromal corneal ring segments. METHODS AND PATIENTS: This was an observational case series study. A total of 147 eyes of 147 patients with keratoconus, 74 of which had undergone corneal ring segment placement, were prospectively evaluated. IOP was measured using the tonometers Tonopen XL, Pascal dynamic contour tonometer, iCare Pro, ocular response analyzer (ORA), and Goldmann applanation (GAT) in random order...
September 21, 2016: Journal of Glaucoma
Oliver L Yeh, Karine D Bojikian, Mark A Slabaugh, Philip P Chen
PURPOSE: To examine refractive outcomes after phacoemulsification in eyes with prior trabeculectomy. DESIGN: Retrospective observational case-control study METHODS:: Comparison of eyes of glaucoma patients undergoing cataract surgery after trabeculectomy (study group) with a matched group with medically controlled glaucoma (control group). Laser interferometry was used to obtain ocular biometry. We measured the difference between the expected and actual postoperative refraction using third-generation and fourth-generation intraocular lens (IOL) prediction formulae (Haigis, Holladay 2, Hoffer Q, and SRK-T)...
September 21, 2016: Journal of Glaucoma
Amit Meshi, Sharon Armarnik, Michael Mimouni, Fani Segev, Ori Segal, Hagai Kaneti, Ehud I Assia, Noa Geffen
PURPOSE: To investigate the effect of modern vaginal labor using epidural anesthesia on the intraocular pressure (IOP) and on the mean ocular perfusion pressure (MOPP) in healthy women. PATIENTS AND METHODS: In this prospective observational study, eligible candidates were healthy pregnant women for vaginal delivery with epidural anesthesia, with a singleton pregnancy, who were admitted to the delivery room in the first phase of the first stage of labor. Demographic data as well as medical and obstetric history were obtained at baseline, followed by performance of a biomicroscopic examination...
September 21, 2016: Journal of Glaucoma
Wei Zhou, Eric R Muir, Steven Chalfin, Kundandeep S Nagi, Timothy Q Duong
PURPOSE OF THE STUDY: The purpose of the study was to evaluate neurodegeneration along brain visual pathways in primary open angle glaucoma (POAG) using improved analysis methods of volumetric and diffusion tensor magnetic resonance imaging (MRI) data. METHODS: Eleven POAG patients (60.0±9.2 y) with primarily mild to moderate POAG and 11 age-matched controls (55.9±7.5 y) were studied using structural and diffusion tensor MRI. Surface-based segmentation was applied to structural MRI to obtain visual cortical area and volume...
September 21, 2016: Journal of Glaucoma
Damla Erginturk Acar, Ugur Acar, Zuhal Ozen Tunay, Ozdemir Ozdemir
PURPOSE: To evaluate the effects of diode laser treatment on intraocular pressure (IOP) of premature infants with retinopathy of prematurity (ROP). PATIENTS AND METHODS: The premature infants who underwent retinal laser photocoagulation therapy for ROP, and gestational age-matched, birth weight-matched, and sex-matched premature infants with ROP which recovered spontaneously without any treatment were enrolled into the study. Anterior segment examination and longitudinal IOP and central corneal thickness measurements were performed 5 times as follows: 1 day before the laser treatment (T0), and 24 hours (T1), 1 week (T2), 1 month (T3), and 3 months (T4) after the laser treatment...
September 21, 2016: Journal of Glaucoma
Matthew D Benson, Imran Jivraj, Karim F Damji, Carlos E Solarte
PURPOSE: To report a rare case of congenital glaucoma in a patient with CHARGE syndrome, present gonioscopic photographs, and explore mechanisms of disease that may account for this association. PATIENTS AND METHODS: We describe a 35-week-old girl with previously diagnosed CHARGE syndrome who presented with corneal edema, buphthalmos, and elevated intraocular pressure in the left eye. She was subsequently diagnosed with congenital glaucoma and started on topical and oral therapy...
September 21, 2016: Journal of Glaucoma
Claudio I Perez, Felipe Mellado, Alex Jones, Ricardo Colvin
PURPOSE OF THE STUDY: The purpose of the study was to report and evaluate outcomes of trabeculectomy with use of a subconjunctival biodegradable collagen matrix implant. PATIENTS AND METHODS: Retrospective review of trabeculectomy with Ologen implant of 65 eyes of 58 patients by the same surgeon from October, 2011 to October, 2014. Exclusion criteria were <6 months of follow-up after surgery, and uveitic or neovascular glaucoma. Demographic characteristics of the study population, visual acuity, intraocular pressure (IOP), glaucoma medications, bleb characteristics, and early and late postoperative complications were recorded...
September 21, 2016: Journal of Glaucoma
Kyung Rim Sung
No abstract text is available yet for this article.
September 21, 2016: Journal of Glaucoma
Aparna Rao, Debananda Padhy, Harika Mudunuri, Avik K Roy, Sarada P Sarangi, Gopinath Das
OBJECTIVE: To compare the variability of central field index (CFI) versus visual field index (VFI) in stable glaucoma with central fixation involvement. MATERIALS AND METHODS: For this retrospective study, we identified multiple visual fields (VFs) of patients with repeatable central fixation involvement on Humphrey VFs (24-2 and 10-2 program) which were stable (clinically and on VFs) over a very short period of 2 to 3 months. The VFI and CFI were calculated as described in earlier reports...
September 15, 2016: Journal of Glaucoma
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