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European Journal of Cancer Prevention

Eunjoo Kim, Gus A Wright, Roger S Zoh, Bhimanagouda S Patil, Guddadarangavvanahally K Jayaprakasha, Evelyn S Callaway, Ivan Ivanov, Nancy D Turner, Robert S Chapkin
Multicomponent therapy has gained interest for its potential to synergize and subsequently lower the effective dose of each constituent required to reduce colon cancer risk. We have previously showed that rapidly cycling Lgr5 stem cells are exquisitely sensitive to extrinsic dietary factors that modulate colon cancer risk. In the present study, we quantified the dose-dependent synergistic properties of dietary n-3 polyunsaturated fatty acids (PUFA) and curcumin (Cur) to promote targeted apoptotic deletion of damaged colonic Lgr5 stem cells...
September 18, 2018: European Journal of Cancer Prevention
Simona Catalani, Francesca Donato, Cesare Tomasi, Enrico Pira, Pietro Apostoli, Paolo Boffetta
We carryied out a meta-analysis of studies on exposure to polychlorinated biphenyls (PCBs) and risk of non-Hodgkin lymphoma (NHL). Through a systematic search of the literature, we identified relative risks (RRs) for PCB exposure and NHL risk in 30 populations (10 occupational exposure, seven high environmental exposure, 13 without special exposure). We performed random effects meta-analyses for exposure to all PCBs, specific PCB congeners and risk of all NHL and NHL subtypes. The meta-RR for studies of occupational exposure, high environmental exposure, and no special exposure were 0...
September 17, 2018: European Journal of Cancer Prevention
Wanshui Yang, Yingfang Shi, Xiumei Ke, Haina Sun, Jianchao Guo, Xin Wang
Previous observational studies have inconsistently suggested that poor sleep is a novel risk factor for breast cancer (BC). However, these studies mainly focused on sleep duration; other sleep domains were rarely reported. The aim of this study was to evaluate the association of a broad range of sleep domains with the risk of BC incidence. We used a community-based 1 : 1 individual matched case-control design that included 401 female patients with incident BC and 401 age-matched and area-matched female controls in Jiujiang, China...
September 4, 2018: European Journal of Cancer Prevention
Chung-Yu Lai, Chih-Ling Kerr, Chia-Chen Huang, Chun-Chieh Chen, Chin-Hung Tsai, Yu-Min Tang, Pei-Yu Chen, You-Rong Chen, Ruey-Hong Wong
Tea polyphenols are strong antioxidants, which can be rapidly O-methylated by catechol-O-methyltransferase (COMT). Thus, it is possible that the genetic polymorphism of COMT can modulate the association of green tea consumption and lung cancer. Here, we designed a case-control study to evaluate the combined effect of green tea consumption and COMT genotypes on the risk of lung cancer. A total of 237 lung cancer patients and 474 healthy controls were recruited. Questionnaires were administered to obtain demographic data, smoking status, green tea consumption, fruits and vegetables intake, exposure to cooking fumes, and family history of lung cancer...
August 28, 2018: European Journal of Cancer Prevention
Mariana Brandão, Satish Tulsidás, Albertino Damasceno, Carla Silva-Matos, Carla Carrilho, Nuno Lunet
Cervical cancer is the most common cancer in Mozambique, reflecting the high prevalence of both human papillomavirus and HIV infections. A national screening program for cervical cancer was started in 2009, using the visual inspection with acetic acid and cryotherapy, targeting women aged 30-55 years. We aimed to estimate the self-reported prevalence and determinants of cervical cancer screening uptake in Mozambique. A cross-sectional study of a representative sample of the women aged 15-64 years (n=1888) was carried out in 2014/2015 following the WHO-Stepwise Approach to Chronic Disease Risk Factor Surveillance...
July 16, 2018: European Journal of Cancer Prevention
Pengcheng Wang, Yuwei Chen, Lei Wang, Yang Wu, Lichun Wang, Yongning Wu, Zhiyong Gong
Folic acid is a necessary micronutrient for normal human growth and development. Benzo(a)pyrene (BaP) is a ubiquitously distributed environmental pollutant and its metabolite, benzo(a)pyrene-diol-epoxide, is known to exert a strong teratogenic and carcinogenic effect on the body's tissues and cells. The aim of this study was to investigate the mechanism by which folic acid can inhibit the toxic effects of BaP both in vivo and in vitro. We measured changes in 16HBE cell activity affected by the intervention of folic acid on BaP using the cell counting kit-8 assay and that of cell cycle distribution by flow cytometry...
July 16, 2018: European Journal of Cancer Prevention
Pei-Fen Kuan, Zhongyuan Mi, Panos Georgopoulos, Dana Hashim, Benjamin J Luft, Paolo Boffetta
DNA methylation has emerged as a promising target linking environmental exposures and cancer. The World Trade Center (WTC) responders sustained exposures to potential carcinogens, resulting in an increased risk of cancer. Previous studies of cancer risk in WTC-exposed responders were limited by the deficiency in quantitative and individual information on exposure to carcinogens. The current study introduces a new exposure-ranking index (ERI) for estimating cancer-related acute and chronic exposures, which aimed to improve the ability of future analyses to estimate cancer risk...
July 11, 2018: European Journal of Cancer Prevention
Zi-Yi Jin, Gina Wallar, Jin-Yi Zhou, Jie Yang, Ren-Qiang Han, Pei-Hua Wang, Ai-Min Liu, Xiao-Ping Gu, Xiao-Feng Zhang, Xu-Shan Wang, Ming Su, Xu Hu, Zheng Sun, Gang Li, Li-Na Mu, Qing-Yi Lu, Xing Liu, Li-Ming Li, Na He, Ming Wu, Jin-Kou Zhao, Zuo-Feng Zhang
Garlic consumption has been associated inversely with esophageal cancer (EC); however, its interactions with tobacco smoking and alcohol consumption have never been evaluated in an epidemiological study. We evaluated the potential interactions between garlic intake and tobacco smoking as well as alcohol consumption in a population-based case-control study with 2969 incident EC cases and 8019 healthy controls. Epidemiologic data were collected by face-to-face interviews using a questionnaire. The adjusted odds ratio (OR) and 95% confidence interval (CI) were estimated and additive and multiplicative interactions were evaluated using unconditional logistic regression models, adjusting for potential confounding factors...
July 11, 2018: European Journal of Cancer Prevention
Maki Kobayashi, Hiroshi Kawachi, Samara Pasternak, Carlos Delgado, Pablo Pinto, Takashi Ito, Stanko Karelovic, Hernan Carrasco, Koji Tanaka, Takuya Okada, Tomoyuki Odagaki, Alejandro J Zárate, Alejandra Ponce, Udo Kronberg, Francisco López-Köstner, Masahiro Tsubaki, Tatsuyuki Kawano, Yoshinobu Eishi
A national colorectal cancer (CRC) screening program began in Chile in 2012, which is an international collaboration between Japan and Chile and is based on a standardized protocol supported by Tokyo Medical and Dental University. We describe the results from the first 2 years of screening at one public hospital in Punta Arenas, Chile. Of 4124 asymptomatic individuals aged between 50 and 75 years, 485 participants with immunological fecal occult blood test values of at least 100 ng/ml and/or those with family histories of CRC underwent colonoscopies...
June 28, 2018: European Journal of Cancer Prevention
Hai-Fang Wang, Ai-Lin Yao, Yan-Yan Sun, Ai-Hua Zhang
Dietary patterns, which reflect overall diet and possible nutrient and food interactions, have been reported to be related to ovarian cancer (OC) risk. However, studies on the relationship between dietary patterns and OC risk have been inconsistent. Thus, we carried out a systematic meta-analysis to assess the relationship between dietary patterns and the risk of OC. Relevant studies are identified by searching the Medline and Embase electronic databases up to December 2016. The Cochrane Q statistic and the I statistical were used to evaluate heterogeneity...
September 2018: European Journal of Cancer Prevention
Yue Wang, Helen Yang, Chun-Jian Shen, Jin-Nian Ge, Jie Lin
Many epidemiologic studies have reported that alcohol is a risk factor for colorectal cancer. To further evaluate the association, we carried out a case-control study in the Han Chinese population. From February 2008 to February 2013, we carried out a hospital-based case-control study on colorectal cancer. Information was collected using a questionnaire. Cases were 310 patients with colorectal cancer; 620 healthy matched controls were also recruited. Multiple logistic regression was used to estimate the odds ratios (OR) and the corresponding 95% confidence intervals...
September 2018: European Journal of Cancer Prevention
Iman El Sayed, Fayek Elkhwsky, Carlo La Vecchia, Gianfranco Alicandro
No abstract text is available yet for this article.
September 2018: European Journal of Cancer Prevention
Eun Kyung Choe, Young Lee, Jeong Yeon Cho, Seung Ho Choi, Boram Park, Jong-Eun Lee, Eun Young Cho
We investigated the genetic markers associated with elevated serum prostate-specific antigen (sPSA) levels to improve the predictive power of sPSA in screening for prostate cancer. A genome-wide association study was carried out among 4124 healthy Korean male adults using the Affymetrix Axiom Customized Biobank Genotyping Arrays for sPSA levels. A subgroup analysis for increased sPSA levels who underwent a prostate biopsy (n=64) was also carried out. We detected 11 single nucleotide polymorphisms (SNPs) near the Solute carrier family 45member 3, AGAP7P, MSMB, LOC101929917, and KLK3 genes associated with sPSA levels...
September 2018: European Journal of Cancer Prevention
Jovana Stojanovic, Sonja Milovanovic, Roberta Pastorino, Ivo Iavicoli, Stefania Boccia
This study aims to summarize the current knowledge on the relationship between genetic polymorphisms, occupational exposures, and urinary tract cancers. We searched MEDLINE, ISI Web of science, and SCOPUS online databases for all articles published in English language up to September 2016. A meta-analysis was performed to provide summary estimates for the association between a certain genetic polymorphism, occupational exposure and bladder cancer (BC) or kidney cancer (KC), when appropriate. Fifteen studies on BC and six on KC were deemed eligible for the review...
September 2018: European Journal of Cancer Prevention
Savas Tsikis, Lea Hoefer, George Bethimoutis, Electra Nicolaidou, Vassilios Paparizos, Christina Antoniou, Leonidas Chardalias, Georgios-Emmanouil Stavropoulos, Shruti Sharma, Bradley C Long, Ibro Mujacic, Sabah Kadri, Jeremy P Segal, Larissa V Furtado, John Schneider, Angella Charnot-Katsikas
The aim of this study was to determine the risk factors, genotype-specific prevalence, and concordance of human papillomavirus (HPV) infections at three anatomical sites in a cohort of high-risk Greek men. Patients were recruited from sexually transmitted infection and HIV clinics in Athens. Samples were obtained from oral, penile, and anal sites of 294 study participants and HPV testing was performed on 882 samples using next-generation sequencing. Patients also completed a questionnaire assessing risk factors for infection...
September 2018: European Journal of Cancer Prevention
Giulia Carreras, Laura Iannucci, Giuseppe Costa, Elisabetta Chellini, Giuseppe Gorini
Smoking cessation is the key cancer and cardiovascular disease (CVD) prevention action for smokers; however, smokers can still benefit from earlier diagnosis. This study aims to investigate behaviours towards cancer and CVD prevention by smoking habits in Italy. The study relies on data from a large Italian population-based survey carried out in 2013 on a sample of 119 073 individuals. We studied the relationship between smoking habits and the participation in cancer (cervical, breast and colorectal) screening programmes, or CVD prevention (performing cholesterol, blood pressure and glycaemia exams) using a multilevel logistic regression model...
September 2018: European Journal of Cancer Prevention
Eleni Klinaki, Michail Katsoulis, Carlo La Vecchia, Antonia Trichopoulou
To investigate the relative risk of cancer development in rheumatoid arthritis (RA) patients in Greece after taking into consideration treatment modalities. The present analysis used data on the medical history of 26 331 participants in the Greek arm of the European Prospective Investigation into Cancer and Nutrition that were collected at enrollment and thereafter during active follow-up. A history of RA and of drug treatment for the disease, as reported at baseline examination, was linked to cases of cancer reported during follow-up...
September 2018: European Journal of Cancer Prevention
Géric Maura, Christophe Chaignot, Alain Weill, François Alla, Isabelle Heard
Cervical cancer screening in young women may lead to the detection of lesions with a high potential for spontaneous regression and no benefit of surgery. French guidelines recommend initiating cervical cancer screening by the Pap test from the age of 25 years. To date, no French nationwide study has assessed cervical cancer screening in young women and the related subsequent work-up and surgical procedures among screen-positive women. Using data from the French national healthcare databases (around 50 million beneficiaries), annual and 3-year Pap test screening rates were calculated among women aged 15-24 years between 2007 and 2013...
September 2018: European Journal of Cancer Prevention
Erin L Symonds, Charles Cock, Rosie Meng, Stephen R Cole, Robert J L Fraser, Graeme P Young
Participation rates in colorectal cancer (CRC) screening programmes using faecal occult blood tests (FOBTs) are low. Nonparticipation is commonly attributed to psychosocial factors, but some medical conditions also prevent screening. These barriers might be partially overcome if a blood test for CRC screening was available. This study determined whether people who had always declined screening by FOBT would participate if offered a blood test. An audit of registrants within a personalized CRC screening programme was undertaken to determine the reasons for regular nonparticipation in FOBT...
September 2018: European Journal of Cancer Prevention
Awfa Y Alazzeh, Firas S Azzeh
We carried out a case-control study to investigate the effects of some lifestyle patterns on the occurrence of colorectal cancer (CRC) in the city of Mecca, Saudi Arabia. Parameters included BMI, employment, family income, educational level, family size, exercise, cancer awareness, diabetes, and hypertension. Individuals of both groups (n=164 for control group, n=137 for CRC group) completed a questionnaire with the help of trained dietitians. Results showed that limited cancer awareness was found to increase the risk of CRC [odds ratio (OR)=49...
September 2018: European Journal of Cancer Prevention
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