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European Journal of Cancer Prevention

Yusuke Kobayashi, Kouji Banno, Haruko Kunitomi, Shimpei Nagai, Takayuki Takahashi, Mayuka Anko, Moito Iijima, Takashi Takeda, Yusuke Matoba, Kanako Nakamura, Kosuke Tsuji, Eiichiro Tominaga, Daisuke Aoki
Novel pharmacological therapies are in development for cancer, ranging from conventional chemotherapeutic drugs to molecular targeted drugs, antibody-based drugs, and immune checkpoint inhibitors, which are developed using new technologies. However, the increasing cost of new drug development is increasing the costs of national healthcare and putting pressure on government finances worldwide. Under these circumstances, drug repositioning (i.e. discovering novel effects of existing drugs, thereby allowing their use to treat other diseases) has become a major focus because of reliability and cost reduction...
November 8, 2018: European Journal of Cancer Prevention
Sharada H Sharma, Vinothkumar Rajamanickam, Sangeetha Nagarajan
Suppression of colorectal cancer by means of chemoprevention is gaining great attention owing to promising outcomes with less adverse effects in preclinical and clinical trials. The present study aims to explore the mechanism of chemoprevention by p-coumaric acid (p-CA) in a short-term preclinical model of colon cancer. 1,2-dimethylhydrazine-administered rats supplemented with p-CA showed downregulation of the expression of colonic proteins, namely, cyclin B1, cdc2, and mdm2, which regulate cell cycle, and immediate early response genes, namely, c-fos, c-jun and c-myc, which regulate cell proliferation...
November 6, 2018: European Journal of Cancer Prevention
Inês A Gomes, Ana Miranda, Carla Nunes
Breast cancer (BC) is the most frequent malignancy in Portuguese women, and more than half of the registered cases live in the south of the country. The main of this study was to characterize patients with locoregional and metastatic incident BC living in the Southern Portuguese and Madeira regions in 2005-2012 according to demographic, clinical and contextual characteristics. Additionally it aimns to find the associations and relative influences of these factors with locoregional or metastatic disease at diagnosis...
November 6, 2018: European Journal of Cancer Prevention
Mai V Nguyen, Mo T Tran, Chi TDu Tran, Quang H Tran, Thuy Tv Tuong, Lam N Phung, Huyen X Vu, Linh C Le, Paolo Boffetta, Hung N Luu
The incidence of childhood brain tumors (CBT) has increased worldwide, likely resulting from the improvements of early diagnostics. We conducted a systematic review and meta-analysis to clarify the association between birth order and CBT. We followed established guidelines to systematically search Ovid Medline, PubMed, and the Cochrane Library for English language studies, published before March 2018. Quality assessment was performed using the Newcastle-Ottawa Scale. Meta-analysis provided pooled risk estimates and their 95% confidence intervals (CIs) for birth order and CBT...
November 5, 2018: European Journal of Cancer Prevention
Nagisa Mori, Norie Sawada, Taichi Shimazu, Taiki Yamaji, Atsushi Goto, Ribeka Takachi, Junko Ishihara, Motoki Iwasaki, Manami Inoue, Shoichiro Tsugane
We aimed to assess the association between cruciferous vegetable intake and colorectal cancer (CRC) development among Japanese adults aged between 45 and 74 years in the Japan Public Health Center-based Prospective Study. During 1 325 853 person-years of follow-up, 2612 CRC cases were identified. The association of cruciferous vegetable intake with CRC risk was assessed using a Cox proportional hazard regression model to compute hazard ratios (HRs) and 95% confidence intervals (CIs), adjusted for potential confounders...
November 5, 2018: European Journal of Cancer Prevention
Eszter A Janka, Kriszta Kékedi, Tünde Várvölgyi, Emese Gellén, Borbála Kiss, Éva Remenyik, Gabriella Emri
There is a great need for efficient and cost-effective melanoma screening, but this is not yet solved. Epidemiological studies on trends in melanoma incidence by tumour thickness, anatomical site and demographical data can help to improve public health efforts regarding earlier melanoma diagnosis. We aimed to study the trends in the incidence and characteristics of patients and their melanoma in North-East Hungary from 2000 to 2014. Data were obtained from a university hospital-based registry. A total of 1509 cutaneous invasive melanomas of 1464 patients were included in the study...
November 5, 2018: European Journal of Cancer Prevention
Wei Ma, Bei Shi, Fangkun Zhao, Yunfei Wu, Feng Jin
The purpose of this study was to describe breast atypical hyperplasia (BAH)-related gene expression and to systematically analyze the functions, pathways, and networks of BAH-related hub genes. On the basis of natural language processing, gene data for BAH were extracted from the PubMed database using text mining. The enriched Gene Ontology terms and Kyoto Encyclopedia of Genes and Genomes pathways were obtained using DAVID ( A protein-protein interaction network was constructed using the STRING database...
November 2, 2018: European Journal of Cancer Prevention
Hilal A Wani, Sabhiya Majid, Arif A Bhat, Shajrul Amin, Rabia Farooq, Showkat A Bhat, Nissar A Naikoo, Mushtaq A Beigh, Showkat A Kadla
Globally, colorectal cancer (CRC) is the third most commonly diagnosed cancer in males and the second most commonly diagnosed cancer in females, with 1.4 million new cases and almost 694 000 deaths estimated to have occurred in 2012. The development and progression of CRC is dictated by a series of alterations in diverse genes mostly proto-oncogenes and tumor suppressor genes. In this dreadful disease disturbances different from mutations called as epigenetic regulations are also taken into consideration and are thoroughly investigated...
October 30, 2018: European Journal of Cancer Prevention
Jie Lin, Christine Kamamia, Craig D Shriver, Kangmin Zhu
To study racial differences in tumor stage at diagnosis among Black and White patients with renal cell carcinoma (RCC) by histologic type and time period. The patients were Black and White patients with RCC from 1999 to 2011 derived from the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. Multinomial logistic regression was used to assess the associations between cancer stage and race and then stratified by histology and diagnosis year. Compared to Whites, Blacks were less likely to be diagnosed with regional disease [odds ratio (OR)=0...
October 29, 2018: European Journal of Cancer Prevention
Mi Ah Han, Jin Hwa Kim, Han Soo Song
Previous epidemiological studies have reported persistent organic pollutants (POPs) and some nonpersistent pesticides and the risk of thyroid cancer. The aim of this study was to assess the association between exposure to POPs, pesticides, and thyroid cancer by carrying out a meta-analysis. Literature searches were performed using PubMed, Embase, and reference lists of relevant articles. Summary risk estimates for thyroid cancer were calculated using fixed-effects and random-effects models. In addition, several subgroup and sensitivity analyses were carried out...
October 22, 2018: European Journal of Cancer Prevention
Chih-Hsing Hung, Yi-Ching Lin, Yu-Han Chang, Yu-Chih Lin, Hsin-Yi Huang, Wei-Ju Yeh, Ting-Yi Wu, Ming-Feng Hou
Both breast cancer and autoimmune diseases (ADs) are predominant in women. NSAIDs are common medications for AD. Evidence on the association between NSAIDs use and breast cancer risk is controversial. We investigated the association between NSAIDs exposure and breast cancer risk in female patients with AD. AD patients older than 18 years of age were enrolled from Taiwan Longitudinal Health Insurance Database 2005. The NSAID users were defined as AD patients who had ever taken NSAIDs for at least 3 months between 2000 and 2009...
October 18, 2018: European Journal of Cancer Prevention
Lan Kluwe, Christian Hagel, Reinhard E Friedrich, Claudia Schnabel, Gerhard Schön, Victor Mautner
Vitamin D and its receptor may play a role in preventing tumor development and progression. As such antineoplastic effects are expected to be weak and to act over long periods, conditions with increased tumor incidence, such as the neurofibromatosis type 1 (NF1), provide suitable study models. We previously found an inverse correlation of serum 25(OH)D concentration with number of neurofibromas in NF1. Here we aim to further explore the role of the vitamin D receptor. A total of 141 adult NF1 patients were included in the study...
October 5, 2018: European Journal of Cancer Prevention
Zheng Zhou, Shen-Dan Nie, Bo Jiang, Jun Wang, Pin Lv
To investigate risk factors for extrahepatic cholangiocarcinoma (ECC) in China. A total of 200 ECC cases and 200 matched control were included in the study. The presence of cigarette smoking, alcohol drinking, choledocholithiasis, primary sclerosing cholangitis, liver fluke infection (Clonorchis sinensis), diabetes mellitus, was investigated through clinical records. Blood from all cases was tested for hepatitis B surface antigen. Odds ratios (OR) and 95% confidence intervals (CIs) were estimated using conditional logistic regression...
October 5, 2018: European Journal of Cancer Prevention
Ana Barbosa, Ana Rute Costa, Filipa Fontes, Teresa Dias, Susana Pereira, Nuno Lunet
The aim of the study was to describe changes in health behaviours and BMI after breast cancer diagnosis, depicting the potential influence of sociodemographic, clinical and psychological characteristics. A total of 428 breast cancer patients were prospectively followed for 3 years, since diagnosis. At the end of follow-up, women were classified regarding their adherence to recommendations for cancer prevention, prediagnosis and after 3 years, including not smoking, alcohol consumption up to one drink per day, intake of at least five portions per day of fruits and/or vegetables, physical activity and body mass index (BMI) less than 25...
September 27, 2018: European Journal of Cancer Prevention
Ana Ferro, Samantha Morais, Claudio Pelucchi, Nuria Aragonés, Manolis Kogevinas, Lizbeth López-Carrillo, Reza Malekzadeh, Shoichiro Tsugane, Gerson S Hamada, Akihisa Hidaka, Raúl U Hernández-Ramírez, Malaquias López-Cervantes, David Zaridze, Dmitry Maximovitch, Farhad Pourfarzi, Zuo-Feng Zhang, Guo-Pei Yu, Mohammadreza Pakseresht, Weimin Ye, Amelie Plymoth, Marcis Leja, Evita Gasenko, Mohammad H Derakhshan, Eva Negri, Carlo La Vecchia, Bárbara Peleteiro, Nuno Lunet
Smoking has been associated with acquisition and increased persistence of Helicobacter pylori infection, as well as with lower effectiveness of its eradication. A greater prevalence of infection among smokers could contribute to the increased risk for gastric cancer. We aimed to estimate the association between smoking and seropositivity to H. pylori through an individual participant data pooled analysis using controls from 14 case-control studies participating in the Stomach Cancer Pooling Project. Summary odds ratios and prevalence ratios (PRs), adjusted for age, sex and social class, and the corresponding 95% confidence intervals (CIs) were estimated through random-effects meta-analysis...
September 27, 2018: European Journal of Cancer Prevention
Vivian H T So, Andrew A Channon, Mohamed M Ali, Leena Merdad, Sultana Al Sabahi, Huda Al Suwaidi, Abdullah Al Ajeel, Nabil Osman, Tawfik A M Khoja
In Gulf Cooperation Council States, there is limited information on national levels of mammography and Pap smear screening uptake. The aim of this study is to provide a baseline for national estimates for mammography and Pap smear screening and to explore associations between screening uptake and socioeconomic factors. The nationally representative World Health Survey Plus, implemented in 2008/2009 in Kuwait, Oman, Saudi Arabia and United Arab Emirates (UAE), was used. Uptake of mammography and Pap smear was estimated for each country, followed by the examination of associations between screening and a range of socioeconomic variables...
September 26, 2018: European Journal of Cancer Prevention
Weisong Xu, Hui Fan, Zhijuan Han, Yufeng Liu, Yiping Wang, Zhenming Ge
There were inconsistent results with respect to the correlation between consumption of wine and the development of colorectal cancer (CRC). We carried out a meta-analysis to investigate this issue. We included observational studies on the aforementioned relationship according to a literature search of Embase and Pubmed from inception till 28 February 2017. The summary relative risk (SRR) and 95% confidence intervals (CI) were calculated using a random-effects model. A total of eight case-control and nine cohort studies were identified, involving 12 110 CRC cases...
September 21, 2018: European Journal of Cancer Prevention
Eunjoo Kim, Gus A Wright, Roger S Zoh, Bhimanagouda S Patil, Guddadarangavvanahally K Jayaprakasha, Evelyn S Callaway, Ivan Ivanov, Nancy D Turner, Robert S Chapkin
Multicomponent therapy has gained interest for its potential to synergize and subsequently lower the effective dose of each constituent required to reduce colon cancer risk. We have previously showed that rapidly cycling Lgr5 stem cells are exquisitely sensitive to extrinsic dietary factors that modulate colon cancer risk. In the present study, we quantified the dose-dependent synergistic properties of dietary n-3 polyunsaturated fatty acids (PUFA) and curcumin (Cur) to promote targeted apoptotic deletion of damaged colonic Lgr5 stem cells...
September 18, 2018: European Journal of Cancer Prevention
Simona Catalani, Francesca Donato, Cesare Tomasi, Enrico Pira, Pietro Apostoli, Paolo Boffetta
We carryied out a meta-analysis of studies on exposure to polychlorinated biphenyls (PCBs) and risk of non-Hodgkin lymphoma (NHL). Through a systematic search of the literature, we identified relative risks (RRs) for PCB exposure and NHL risk in 30 populations (10 occupational exposure, seven high environmental exposure, 13 without special exposure). We performed random effects meta-analyses for exposure to all PCBs, specific PCB congeners and risk of all NHL and NHL subtypes. The meta-RR for studies of occupational exposure, high environmental exposure, and no special exposure were 0...
September 17, 2018: European Journal of Cancer Prevention
Wanshui Yang, Yingfang Shi, Xiumei Ke, Haina Sun, Jianchao Guo, Xin Wang
Previous observational studies have inconsistently suggested that poor sleep is a novel risk factor for breast cancer (BC). However, these studies mainly focused on sleep duration; other sleep domains were rarely reported. The aim of this study was to evaluate the association of a broad range of sleep domains with the risk of BC incidence. We used a community-based 1 : 1 individual matched case-control design that included 401 female patients with incident BC and 401 age-matched and area-matched female controls in Jiujiang, China...
September 4, 2018: European Journal of Cancer Prevention
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