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European Journal of Cancer Prevention

Pei-Fen Kuan, Zhongyuan Mi, Panos Georgopoulos, Dana Hashim, Benjamin J Luft, Paolo Boffetta
DNA methylation has emerged as a promising target linking environmental exposures and cancer. The World Trade Center (WTC) responders sustained exposures to potential carcinogens, resulting in an increased risk of cancer. Previous studies of cancer risk in WTC-exposed responders were limited by the deficiency in quantitative and individual information on exposure to carcinogens. The current study introduces a new exposure-ranking index (ERI) for estimating cancer-related acute and chronic exposures, which aimed to improve the ability of future analyses to estimate cancer risk...
July 11, 2018: European Journal of Cancer Prevention
Zi-Yi Jin, Gina Wallar, Jin-Yi Zhou, Jie Yang, Ren-Qiang Han, Pei-Hua Wang, Ai-Min Liu, Xiao-Ping Gu, Xiao-Feng Zhang, Xu-Shan Wang, Ming Su, Xu Hu, Zheng Sun, Gang Li, Li-Na Mu, Qing-Yi Lu, Xing Liu, Li-Ming Li, Na He, Ming Wu, Jin-Kou Zhao, Zuo-Feng Zhang
Garlic consumption has been associated inversely with esophageal cancer (EC); however, its interactions with tobacco smoking and alcohol consumption have never been evaluated in an epidemiological study. We evaluated the potential interactions between garlic intake and tobacco smoking as well as alcohol consumption in a population-based case-control study with 2969 incident EC cases and 8019 healthy controls. Epidemiologic data were collected by face-to-face interviews using a questionnaire. The adjusted odds ratio (OR) and 95% confidence interval (CI) were estimated and additive and multiplicative interactions were evaluated using unconditional logistic regression models, adjusting for potential confounding factors...
July 11, 2018: European Journal of Cancer Prevention
Maki Kobayashi, Hiroshi Kawachi, Samara Pasternak, Carlos Delgado, Pablo Pinto, Takashi Ito, Stanko Karelovic, Hernan Carrasco, Koji Tanaka, Takuya Okada, Tomoyuki Odagaki, Alejandro J Zárate, Alejandra Ponce, Udo Kronberg, Francisco López-Köstner, Masahiro Tsubaki, Tatsuyuki Kawano, Yoshinobu Eishi
A national colorectal cancer (CRC) screening program began in Chile in 2012, which is an international collaboration between Japan and Chile and is based on a standardized protocol supported by Tokyo Medical and Dental University. We describe the results from the first 2 years of screening at one public hospital in Punta Arenas, Chile. Of 4124 asymptomatic individuals aged between 50 and 75 years, 485 participants with immunological fecal occult blood test values of at least 100 ng/ml and/or those with family histories of CRC underwent colonoscopies...
June 28, 2018: European Journal of Cancer Prevention
Carla Carrilho, Filipa Fontes, Satish Tulsidás, Cesaltina Lorenzoni, Josefo Ferro, Mariana Brandão, Ana Ferro, Nuno Lunet
There is scarce information on cancer incidence in Mozambique. We aimed to describe cancer incidence data from the Cancer Registry of the Maputo Central Hospital (MCH) in 2015-2016, for Maputo City dwellers, and to compare the incidence rates with those observed in 1956-1961. Cancers with incidence data in 2015-2016 were identified by the Cancer Registry of the MCH. Crude and age-standardized incident rates (ASIR, per 100 000) - direct method, world standard population - were computed for Maputo City, under the assumption that most cancer cases among this population were identified at the MCH...
June 22, 2018: European Journal of Cancer Prevention
Fereshteh Shojaei, Farshad Yazdani-Nafchi, Mehdi Banitalebi-Dehkordi, Mohammad Chehelgerdi, Milad Khorramian-Ghahfarokhi
Survivin is one of the most cancer-specific proteins overexpressed in almost all malignancies, but is nearly undetectable in most normal tissues in adults. Functionally, as a member of the inhibitor of apoptosis family, survivin has been shown to inhibit apoptosis and increase proliferation. The antiapoptotic function of survivin seems to be related to its ability to inhibit caspases directly or indirectly. Furthermore, the role of survivin in cell cycle division control is related to its role in the chromosomal passenger complex...
May 29, 2018: European Journal of Cancer Prevention
Hong Luo, Yu-Jing Fang, Min-Shan Lu, Zhi-Zhong Pan, Jing Huang, Yu-Ming Chen, Cai-Xia Zhang
The effect of vitamin A (VA) and vitamin E (VE) on colorectal cancer (CRC) risk is controversial. The aim of this study is to examine the association between serum concentrations and dietary intakes of VA and VE and the risk of CRC in Guangdong, China. A total of 535 cases and 552 sex and age-matched (5-year interval) controls were recruited during July 2010 to September 2014. Dietary information was assessed by face-to-face interviews using a validated food frequency questionnaire. Concentrations of VA and VE were measured by high-performance liquid chromatography...
May 24, 2018: European Journal of Cancer Prevention
Yue Wang, Long-Fei Xie, Jie Lin
The association between gallstones or cholecystectomy and the incidence risk of liver cancer is controversial. This is a meta-analysis of observational studies on the role of gallstones or cholecystectomy in primary liver cancer. Relevant studies were identified after the literature search via electronic databases until June 2014. A random-effects model was used to generate pooled multivariable adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Heterogeneity among studies was evaluated using Cochran's Q and I statistics...
May 5, 2018: European Journal of Cancer Prevention
Hélène Willem, Valérie Jooste, Olayide Boussari, Gaëlle Romain, Anne-Marie Bouvier
Staging is essential for scientific exchanges on colorectal cancer. Lack of a consensual definition for synchronous and metachronous metastases for colorectal cancer may introduce artifactual differences between epidemiological studies according to stage. We investigated how variations in the cutoff for the definition of synchronous metastases influenced the stage-specific distribution and incidence and the survival of stage IV patients. Between 2007 and 2013, a total of 4636 cases of colorectal adenocarcinoma were registered in the cancer registry of Burgundy...
May 5, 2018: European Journal of Cancer Prevention
Wu-Xia Luo, Ye Chen, Yun-Tao Li, Jie Tang, Jing Ding, Yang Du, Qiang Wu, Ji-Yan Liu
For treatment of metastatic colorectal cancer, the dynamics of tumor growth is an important factor for treatment decision. However, it is difficult to evaluate the dynamics of tumor growth, especially those of synchronous metastatic diseases. This study aimed to find some indicators related to tumor proliferation to judge the dynamics of tumor progression. The pathological reports and clinical data of 1205 patients with metastatic colorectal cancer were retrospectively reviewed; 75 patients with known relapse time after radical resection were included, and the expression of proliferation-associated proteins was detected by immunohistochemistry...
April 23, 2018: European Journal of Cancer Prevention
Xiao-Yan Huang, Chao Hu
No abstract text is available yet for this article.
July 2018: European Journal of Cancer Prevention
Joséphine Bryere, Olivier Dejardin, Ludivine Launay, Marc Colonna, Pascale Grosclaude, Guy Launoy
The aim of this study was to identify and compare cancer sites whose incidence is influenced by social deprivation. The study population comprised 189 144 cases of cancer diagnosed between 2006 and 2009, recorded in member registries of the French Network of Cancer Registries. Social environment was assessed at an aggregate level using the European Deprivation Index. The association between incidence and socioeconomic status was assessed by a geographical Bayesian Poisson model enabling a reduction of the overall variability and smoothing of the relative risks by sharing information provided by multiple geographic units...
July 2018: European Journal of Cancer Prevention
Giovanni Corso, Paolo Veronesi, Virgilio Sacchini, Viviana Galimberti
No abstract text is available yet for this article.
May 2018: European Journal of Cancer Prevention
Ana Ferro, Samantha Morais, Matteo Rota, Claudio Pelucchi, Paola Bertuccio, Rossella Bonzi, Carlotta Galeone, Zuo-Feng Zhang, Keitaro Matsuo, Hidemi Ito, Jinfu Hu, Kenneth C Johnson, Guo-Pei Yu, Domenico Palli, Monica Ferraroni, Joshua Muscat, Reza Malekzadeh, Weimin Ye, Huan Song, David Zaridze, Dmitry Maximovitch, Nuria Aragonés, Gemma Castaño-Vinyals, Jesus Vioque, Eva M Navarrete-Muñoz, Mohammadreza Pakseresht, Farhad Pourfarzi, Alicja Wolk, Nicola Orsini, Andrea Bellavia, Niclas Håkansson, Lina Mu, Roberta Pastorino, Robert C Kurtz, Mohammad H Derakhshan, Areti Lagiou, Pagona Lagiou, Paolo Boffetta, Stefania Boccia, Eva Negri, Carlo La Vecchia, Bárbara Peleteiro, Nuno Lunet
Tobacco smoking is one of the main risk factors for gastric cancer, but the magnitude of the association estimated by conventional systematic reviews and meta-analyses might be inaccurate, due to heterogeneous reporting of data and publication bias. We aimed to quantify the combined impact of publication-related biases, and heterogeneity in data analysis or presentation, in the summary estimates obtained from conventional meta-analyses. We compared results from individual participant data pooled-analyses, including the studies in the Stomach Cancer Pooling (StoP) Project, with conventional meta-analyses carried out using only data available in previously published reports from the same studies...
May 2018: European Journal of Cancer Prevention
Giovanni Corso, Debora Macis, Paolo Veronesi, Bernardo Bonanni, Viviana Galimberti
No abstract text is available yet for this article.
May 2018: European Journal of Cancer Prevention
Aileen Baecker, Xing Liu, Carlo La Vecchia, Zuo-Feng Zhang
To facilitate regionally specific liver cancer prevention and control, this study estimates the fraction of hepatocellular carcinoma (HCC) cases attributable to five major liver cancer risk factors by geographic region. Prevalence estimates of major HCC risk factors, including chronic infection with hepatitis B and hepatitis C, alcohol drinking, tobacco smoking, obesity, and diabetes, were extracted for each country from the literature, along with recent incidence and risk estimate data, to calculate regionally specific population attributable fractions...
May 2018: European Journal of Cancer Prevention
Geoffrey C Kabat, Mimi Y Kim, Dorothy S Lane, Oleg Zaslavsky, Gloria Y F Ho, Juhua Luo, Wanda K Nicholson, Rowan T Chlebowski, Wendy E Barrington, Mara Z Vitolins, Xiaochen Lin, Simin Liu, Thomas E Rohan
Limited evidence suggests that hyperinsulinemia may contribute to the risk of breast, endometrial, and, possibly, ovarian cancer. The aim of this study was to assess the association of serum glucose and insulin with risk of these cancers in postmenopausal women, while taking into account potential confounding and modifying factors. We studied 21 103 women with fasting baseline insulin and glucose measurements in a subsample of the Women's Health Initiative. The subsample was composed of four studies within Women's Health Initiative with different selection and sampling strategies...
May 2018: European Journal of Cancer Prevention
Jianguang Ji, Jan Sundquist, Kristina Sundquist
Current evidence on congenital malformations in the offspring of cancer survivors is largely inconsistent. Therefore, through this study we aimed to explore the prevalence of congenital malformations in the offspring of cancer survivors. To this end, female cancer survivors were identified from the Swedish Cancer Register and were further linked to the Swedish Medical Birth Register and Hospital Discharge Register to identify congenital malformation in their children at birth or during adulthood between 1987 and 2010...
May 2018: European Journal of Cancer Prevention
Jianguang Ji, Jan Sundquist, Kristina Sundquist
A personal history of autoimmune diseases is associated with an increased incidence of gastric cancer, but whether they share familial susceptibility is still unknown. The contribution of shared environmental or genetic factors toward the observed familial aggregation has not been determined. We used a few Swedish registers, including the Swedish Multigeneration Register and the Cancer Register, to examine the familial risk of gastric cancer among individuals with a family history of a set of autoimmune diseases...
May 2018: European Journal of Cancer Prevention
Clara Castro, Bárbara Peleteiro, Samantha Morais, Milton Severo, Maria José Bento, Nuno Lunet
Variations in the exposure to risk factors may be used to explain past cancer trends and to predict its future burden. This study aimed to develop a model to describe and predict the variation of esophageal cancer incidence in 1995-2005, taking into account changes in exposures to risk factors. We adapted an existing model to calculate the expected variation in the number of esophageal cancer cases, between 1995 and 2005, in Australia, Japan, Italy, Portugal, the UK, and the USA, because of changes in exposures to risk factors, taking into account the corresponding lag times...
May 2018: European Journal of Cancer Prevention
Ana Rute Costa, Luís Pacheco-Figueiredo, Luís Alves, Nuno Lunet
We aimed to quantify the association between a previous cancer diagnosis and medication use, depicting possible sex differences. We analysed data from a representative sample of the Portuguese adult population (n=32 610), which was collected through face-to-face interviews, using a structured questionnaire. The effect of a previous diagnosis of cancer was quantified through prevalence ratios (PR), adjusted for age, education and region of residence. Cancer survivors (CS) reported higher use of prescribed medication, with greater adjusted PR among men (1...
May 2018: European Journal of Cancer Prevention
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