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European Journal of Cancer Prevention

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https://www.readbyqxmd.com/read/28723704/trends-and-territorial-inequalities-of-incidence-and-survival-of-childhood-leukaemia-and-their-relations-to-socioeconomic-status-in-hungary-1971-2015
#1
Zsuzsanna Jakab, Attila Juhasz, Csilla Nagy, Dezso Schuler, Miklos Garami
The Hungarian Childhood Cancer Registry, a population-based national registry of the Hungarian Paediatric Haemato-Oncology Network founded in 1971, monitors the incidence and mortality of childhood cancer. Our aims were to carry out a longitudinal study to investigate the trends and spatial inequalities of incidence and survival of leukaemia, and the association between survival and deprivation in Hungary. All cases of childhood leukaemia and myelodysplasia were analysed (3157 cases, 1971-2015, age: 0-14 years)...
July 18, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28704214/bile-acids-upregulate-brca1-and-downregulate-estrogen-receptor-1-gene-expression-in-ovarian-cancer-cells
#2
Qunyan Jin, Olivier Noel, Mai Nguyen, Lionel Sam, Glenn S Gerhard
Two major risk factors for ovarian cancer include loss-of-function mutations in the BRCA1 (breast cancer 1, early onset) gene and aspects of estrogen metabolism. Modulation of the levels of the normal BRCA1 allele and estrogen receptor expression may therefore be a preventive strategy. Consensus binding motifs for the bile acid-responsive transcription factor farnesoid X receptor were identified in the BRCA1 and estrogen receptor 1 (ESR1) and estrogen receptor 2 (ESR2) genes, supported by chromatin immunoprecipitation sequencing data...
July 12, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28704213/menstrual-pad-a-cervical-cancer-screening-tool-a-population-based-study-in-rural-india
#3
Atul Budukh, Vrushali Palayekar, Amita Maheshwari, Kedar Deodhar, Pallavi Purwar, Sonali Bagal, Ashok Vadigoppula, Manoj Lokhande, Nandkumar Panse, Rajesh Dikshit, Rajendra Badwe
In the rural areas of India, women generally use a piece of old cloth as a menstrual device. The aim of this study was to detect human papilloma virus (HPV) from menstrual blood on the menstrual pad and assess whether this could be a useful screening tool for cervical cancer. In Jamkhed area of rural Maharashtra, (population A), we collected menstrual pads from women who provided consent in the 30-50 year age group. The women who had provided menstrual pads underwent HC2 testing. We standardized the method for extracting DNA by PCR from the menstrual pad...
July 12, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28692588/utilization-of-colonoscopy-and-colonoscopic-findings-among-individuals-aged-40-54-years-with-a-positive-family-history-of-colorectal-cancer-a-cross-sectional-study-in-general-practice
#4
Jasper Plath, Andrea Siebenhofer, Ulrike Haug, Insa Koné, Marlene Hechtner, Irina Blumenstein, Sylvia Schulz-Rothe, Ferdinand M Gerlach, Corina Guethlin
Guidelines recommend early colonoscopy for individuals with a positive family history of colorectal cancer (CRC), but little is known about the utilization of colonoscopy and the frequency of colorectal neoplasms among younger affected individuals in Germany. The aim of this study was to determine the utilization of colonoscopy and the frequency of colorectal neoplasms in this risk group. We conducted a cross-sectional study in a general practice setting. Patients aged 40-54 years with at least one first-degree relative with CRC were identified, counseled on their increased risk, and referred to colonoscopy if they decided to undergo this procedure...
July 7, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28692587/colorectal-cancer-and-markers-of-anemia
#5
Cornelia Schneider, Michael Bodmer, Susan S Jick, Christoph R Meier
Unexplained iron-deficiency anemia is an important marker for colorectal cancer (CRC). Our objectives were as follows: (a) to assess whether the association between anemia and CRC can be detected on the 'Clinical Practice Research Datalink', (b) to evaluate the timing between laboratory changes and CRC detection, and (c) to analyze its association with survival. We conducted a case-control study on patients with an incident CRC diagnosis during 2008-2012 and a 1 : 1-matched control group. We compared anemia markers serum ferritin (SF), hemoglobin (Hb), mean corpuscular volume (MCV), and red blood cell count between cases and controls using conditional logistic regression...
July 7, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28692586/bioactivity-and-prostate-tissue-distribution-of-metformin-in-a-preprostatectomy-prostate-cancer-cohort
#6
Mike M Nguyen, Jessica A Martinez, Chiu-Hsieh Hsu, Mitchell Sokoloff, Robert S Krouse, Blake A Gibson, Raymond B Nagle, Howard L Parnes, Catherine Cordova, H-H Sherry Chow
Metformin has recently been shown to have potential to reduce prostate cancer risk. We conducted a randomized, double-blind, placebo-controlled trial to determine the modulating effects of metformin on tissue and systemic biomarkers of drug activity and its distribution into the prostate tissue. Twenty patients with prostate cancer scheduled to undergo prostatectomy were randomly assigned to receive either extended-release metformin or placebo for a median of 34 days before surgery. Prostatectomy and serum samples were analyzed for metformin concentrations, serum biomarkers of drug activity (prostate-specific antigen, insulin, insulin-like growth factor-1, insulin-like growth factor binding protein 3, sex hormone-binding globulin, and testosterone) and tissue biomarkers of proliferation, apoptosis, cell cycle regulation, and mTOR inhibition...
July 7, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28692585/association-between-alcohol-consumption-and-colorectal-cancer-risk-a-case-control-study-in-the-han-chinese-population
#7
Yue Wang, Helen Yang, Chun-Jian Shen, Jin-Nian Ge, Jie Lin
Many epidemiologic studies have reported that alcohol is a risk factor for colorectal cancer. To further evaluate the association, we carried out a case-control study in the Han Chinese population. From February 2008 to February 2013, we carried out a hospital-based case-control study on colorectal cancer. Information was collected using a questionnaire. Cases were 310 patients with colorectal cancer; 620 healthy matched controls were also recruited. Multiple logistic regression was used to estimate the odds ratios (OR) and the corresponding 95% confidence intervals...
July 7, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28692584/association-between-risk-factors-and-detection-of-cutaneous-melanoma-in-the-setting-of-a-population-based-skin-cancer-screening
#8
Joachim Hübner, Annika Waldmann, Nora Eisemann, Maria Noftz, Alan C Geller, Martin A Weinstock, Beate Volkmer, Rüdiger Greinert, Eckhard W Breitbart, Alexander Katalinic
Early detection is considered to improve the prognosis of cutaneous melanoma. The value of population-based screening for melanoma, however, is still controversial. The aim of this study was to evaluate the predictive power of established risk factors in the setting of a population-based screening and to provide empirical evidence for potential risk stratifications. We reanalyzed data (including age, sex, risk factors, and screening results) of 354 635 participants in the Skin Cancer Research to provide Evidence for Effectiveness of Screening in Northern Germany project conducted in the German state of Schleswig-Holstein (2003-2004)...
July 7, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28683010/the-incidence-rates-and-survival-of-gallbladder-cancer-in-the-usa
#9
Veeravich Jaruvongvanich, Ju Dong Yang, Thoetchai Peeraphatdit, Lewis R Roberts
Gallbladder cancer is a rare malignancy in most countries. The racial and sociodemographic factors associated with its incidence and survival are poorly defined. We aimed to investigate population-based gallbladder cancer incidence and survival trends on the basis of clinical characteristics and sociodemographic factors in the USA. Gallbladder cancer incidence and survival data from 2001 to 2012 were obtained from 18 registries of the Surveillance, Epidemiology, and End Results database. Incidence rates and Joinpoint trends were calculated by demographic subgroup...
July 7, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28079603/genital-use-of-talc-and-risk-of-ovarian-cancer-a-meta-analysis
#10
Wera Berge, Kenneth Mundt, Hung Luu, Paolo Boffetta
Some epidemiological studies suggest an association between genital use of talc powders and increased risk of ovarian cancer, but the evidence is not consistent. We performed a meta-analysis of epidemiological studies to formally evaluate this suspected association. A systematic search was conducted in Medline, Embase, and Scopus, leading to the identification of 24 case-control studies and three cohort studies. In the meta-analysis, we used a random-effect model to calculate summary estimates of the association between genital use of talc and occurrence of ovarian cancer...
July 7, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28683011/is-low-cholesterol-a-risk-factor-for-cancer-mortality
#11
Nader Parsa, Samira Taravatmanesh, Maurizio Trevisan
Although a large number of studies have shown the associations of high plasma lipid profile levels with cancer, few studies demonstrate the association between low serum cholesterol (<160 mg/dl) and risk for cancer mortality. The aim of this study was to determine the association of low serum cholesterol level as a risk factor for mortality in cancer. The prospective cohort studies were conducted on 19 of 52 cohort studies including 30 179 male and 26 005 female participants who were followed up for 9 years...
July 4, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28683009/is-there-an-association-between-trends-in-alcohol-consumption-and-cancer-mortality-findings-from-a-multicountry-analysis
#12
Naomi Schwartz, Diane Nishri, Sandrene Chin Cheong, Norman Giesbrecht, Julie Klein-Geltink
The aim of this analysis is to examine long-term trends in alcohol consumption and associations with lagged data on specific types of cancer mortality, and indicate policy implications. Data on per capita annual sales of pure alcohol; mortality for three alcohol-related cancers - larynx, esophageal, and lip, oral cavity, and pharynx; and per capita consumption of tobacco products were extracted at the country level. The Unobservable Components Model was used for this time-series analysis to examine the temporal association between alcohol consumption and cancer mortality, using lagged data, from 17 countries...
July 4, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28683008/tar-nicotine-and-carbon-monoxide-yield-of-uk-cigarettes-and-the-risk-of-non-muscle-invasive-and-muscle-invasive-bladder-cancer
#13
Frits H M van Osch, Charlotte G G M Pauwels, Sylvia H J Jochems, Ranti Fayokun, Nicholas D James, D Michael A Wallace, Kar-Keung Cheng, Richard T Bryan, Frederik J van Schooten, Maurice P Zeegers
Cigarette smoking is a major risk factor for bladder cancer (BC); however, the impact of cigarette content remains unclear. This study aims to investigate tar, nicotine and carbon monoxide (TNCO) yields of different filtered cigarettes in relation to BC risk. From the Bladder Cancer Prognosis Programme 575 non-muscle-invasive bladder cancer (NMIBC) cases, 139 muscle-invasive bladder cancer (MIBC) cases and 130 BC-free controls with retrospective data on smoking behaviour and cigarette brand were identified...
July 4, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28683007/prophylactic-effects-of-secretion-metabolites-of-dairy-lactobacilli-through-downregulation-of-erbb-2-and-erbb-3-genes-on-colon-cancer-cells
#14
Zeinab Faghfoori, Bahram Pourghassem Gargari, Amir Saber, Maryam Seyyedi, Siavash Fazelian, Ahmad Yari Khosroushahi
Colon cancer is one of the most prevalent cancers, and intestinal microbial community plays a pivotal role in colorectal tumor genesis. Probiotics as live microorganisms may be able to exert an anticancer effect in colon cancer. The aim of this study was to isolate and identify Lactobacillus spp. from traditional dairy products with probiotic properties and to investigate their anticancer effects through ErbB-2 and ErbB-3 gene expression in colon cancer cells. The isolated lactobacilli from yogurt and cheese samples were molecularly identified by blasting of 16-23s rDNA region PCR sequenced products...
July 4, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28683006/height-and-risk-of-colorectal-cancer-a-meta-analysis
#15
Xinyuan Song, Xiuzhen Gong, Tong Zhang, Wenjie Jiang
Several epidemiological studies have investigated the relationship between height and risk of colorectal cancer (CRC), but the results were inconsistent. Thus, a meta-analysis of observational studies was carried out to clarify this association. A literature search was performed in PubMed and Web of Science databases for all relevant studies up to 25 May 2016. The random-effects model was used to calculate the pooled relative risks (RRs) and restricted cubic spline model was adopted for the dose-response analysis...
July 4, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28665812/interventions-to-increase-uptake-of-faecal-tests-for-colorectal-cancer-screening-a-systematic-review
#16
Cédric Rat, Chloé Latour, Rosalie Rousseau, Aurélie Gaultier, Corinne Pogu, Adrian Edwards, Jean-Michel Nguyen
International guidelines promote screening by faecal tests in asymptomatic individuals at average risk of colorectal cancer (CRC), but uptake does not reach recommended levels in most countries. The aim of this study was to synthetize evidence on (a) interventions aiming to increase uptake of faecal tests for CRC screening, in asymptomatic individuals at average risk of CRC, (b) interventions that targeted general practitioner (GP) involvement and (c) interventions that targeted nonresponders or disadvantaged groups...
June 29, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28654436/variability-of-cancer-risk-within-an-area-time-to-complement-the-incidence-rate
#17
Emanuele Crocetti, Francesco Giusti, Carmen Martos, Giorgia Randi, Tadeusz Dyba, Manola Bettio
The aim of this study was to show that age-adjusted cancer incidence rates for an area may not be representative of the incidence in subareas. We propose a simple measure to show the amount of geographical variability. European age-standardized incidence rates (ASRs) for 'all sites excluding nonmelanoma skin cancer', for men, in 2014, for Nordic countries as a whole, for each country (Denmark, Faroe Islands, Finland, Greenland, Iceland, Sweden and Norway) and for their regions, were retrieved from the Nordcan with corresponding standard errors SEs...
June 26, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28639952/toward-a-comprehensive-cancer-registration-in-germany
#18
Bernd Holleczek, Alexander Katalinic
This article presents the current status of the implementation of clinical cancer registration across all German federal states that started in 2013 and that is basis for setting up comprehensive clinical and population-based cancer registries (CRs). A nationwide definition of relevant cancers, a common model of passive registration, a standard basic set of data items as well as a sustainable funding are prerequisites for a standardized collection of cancer data in Germany. For the collected information, the tools and methods used for data collection and processing, for statistical analyses and reporting, the potential synergies of a comprehensive CR implementing the tasks of both a clinical CR and a population-based CR become evident...
June 20, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28617683/estimation-of-population-based-cancer-specific-potential-years-of-life-lost-in-belgium
#19
Geert Silversmit, Evelien Vaes, Liesbet van Eycken
The potential years of life lost (PYLL) observed in a cohort of cancer patients cannot be fully assigned to the cancer as both cancer-related and non-cancer-related deaths contribute. A method is presented to decompose the observed all-cause PYLL into cancer mortality and population background mortality fractions when cause of death information is not available. Furthermore, the association of cancer-specific PYLL with cancer-specific mortality and mean age at diagnosis is explored and the impact of the follow-up window length is examined...
June 14, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28604420/the-impact-of-under-reporting-of-cases-on-the-estimates-of-childhood-cancer-incidence-and-survival-in-estonia
#20
Keiu Paapsi, Margit Mägi, Sirje Mikkel, Kadri Saks, Tiiu Aareleid, Kaire Innos
About 35 new childhood cancer cases are diagnosed in Estonia (population 1.3 million in 2011) every year. Despite continuous improvements in the healthcare system and available cancer treatment options, the survival rates for childhood cancers have appeared to remain lower than the European average. These observations and the accompanying decrease in incidence led us to hypothesize that some nonfatal cases might be missing from the Estonian Cancer Registry (ECR). The aim of this study was to evaluate the completeness of reporting of childhood cancer cases to the ECR and its impact on the estimates of cancer incidence and survival...
June 9, 2017: European Journal of Cancer Prevention
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