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European Journal of Cancer Prevention

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https://www.readbyqxmd.com/read/28542079/adherence-to-mediterranean-diet-and-risk-of-gastric-cancer-results-of-a-case-control-study-in-italy
#1
Jovana Stojanovic, Luca Giraldi, Dario Arzani, Roberta Pastorino, Alberto Biondi, Roberto Persiani, Stefania Boccia, Emanuele Leoncini
The aim of this study is to evaluate the association between adherence to Mediterranean diet (MD) and gastric cancer (GC). A case-control study was carried out at the Fondazione Policlinico 'A. Gemelli' (Rome, Italy) from 2003 to 2015. A total of 223 incident cases and 223 controls were interviewed. Dietary intake was assessed through a validated food frequency questionnaire that collected information on more than 25 food items. The association between adherence to MD and risk of GC was quantified by calculating Odds Ratios (OR) and 95% confidence intervals (CI)...
May 24, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28542078/a-population-level-investigation-of-cancer-clinical-trials-participation-in-a-uk-region
#2
Conan B Donnelly, Amy C Wotherspoon, Melanie Morris, Richard H Wilson, Jingwen J Chen, Victoria Cairnduff, Eileen Morgan, Amy Devlin, Anna T Gavin
The aim of this study was to document cancer trial participation since establishment of the Northern Ireland Cancer Trials Network and investigate population and disease factors associated with trial participation. An independent cohort of over 51 000 cancer patients from the Northern Ireland Cancer Registry covering the same population (2007-2012) was linked to a database of 1316 interventional cancer trial participants in a UK region. The primary outcome measure was participation in an intervention clinical trial...
May 24, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28542077/physical-activity-sedentary-time-and-risk-of-colorectal-cancer-the-singapore-chinese-health-study
#3
Yvonne L Eaglehouse, Woon-Puay Koh, Renwei Wang, Jin Aizhen, Jian-Min Yuan, Lesley M Butler
Singapore has experienced a marked increase in colorectal cancer incidence over the past 40 years. Evidence from prospective studies in Western Europe and the USA suggests that low physical activity and high amounts of sedentary time are associated with increased colorectal cancer risk. The aim of this study is to evaluate these relationships in an Asian population. The Singapore Chinese Health Study enrolled 63 257 adults between 1993 and 1998. At enrollment, participants reported past year physical activity and time spent sitting...
May 24, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28538041/the-frequency-of-bladder-cancer-in-alexandria-egypt-over-the-last-two-decades
#4
Iman El Sayed, Fayek Elkhwsky, Carlo La Vecchia, Gianfranco Alicandro
No abstract text is available yet for this article.
May 19, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28538040/interleukin-10-592c-a-but-not-1082a-g-promoter-single-nucleotide-polymorphism-is-associated-with-a-decreased-risk-of-colorectal-cancer-in-an-ethnic-kashmiri-population-a-case-control-study
#5
Mujeeb Z Banday, Aga S Sameer, Nissar A Chowdri, Ehtishamul Haq
Chronic inflammation influences the development of various cancers including colorectal cancer (CRC). Interleukin-10 (IL-10), an anti-inflammatory cytokine, plays a vital role in several homeostatic physiological processes occurring in the human gastrointestinal tract including intestinal inflammation and is a key regulator of several gastrointestinal tract pathophysiological processes such as inflammatory bowel diseases that are associated with an increased predisposition to CRC. Several studies have reported the association of various polymorphisms in the human IL-10 gene including IL-10 -592C/A and IL-10 -1082A/G single nucleotide polymorphisms (SNPs) with various cancers including CRC, but these SNPs are yet to be studied in a Kashmiri population with respect to CRC risk...
May 19, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28538039/association-of-physical-activity-and-sitting-time-with-incident-colorectal-cancer-in-postmenopausal-women
#6
Anna M Gorczyca, Charles B Eaton, Michael J LaMonte, David O Garcia, Jeanne D Johnston, Ka He, Aurelian Bidulescu, Deborah Goodman, Erik Groessl, Dorothy Lane, Marcia L Stefanick, Polly Newcomb, Charles Mouton, Andrea K Chomistek
Findings from epidemiological studies have found that physical activity (PA) is associated with a lower risk of colorectal cancer (CRC). Recent studies have found an increased CRC risk with higher sitting time (ST); however, many studies did not include PA as a potential confounder. The objective of this project was to investigate the independent and combined associations of ST and PA with the risk of incident CRC, specifically colon and rectal cancer. Participants in the Women's Health Initiative Observational Study (n=74 870), 50-79 years of age self-reported ST and PA at baseline, years 3 and 6...
May 19, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28368946/genetic-polymorphisms-in-tlr1-tlr2-tlr4-and-tlr10-of-helicobacter-pylori-associated-gastritis-a-prospective-cross-sectional-study-in-thailand
#7
Taweesak Tongtawee, Theeraya Bartpho, Soraya Kaewpitoon, Natthawut Kaewpitoon, Chavaboon Dechsukhum, Wilairat Leeanansaksiri, Ryan A Loyd, Krajang Talabnin, Likit Matrakool, Sukij Panpimanmas
The toll-like receptors (TLRs) mediate the recognition of Helicobacter pylori and initiate the innate immune response to infection. We hypothesized those genetic polymorphisms in the TLR1, TLR2, TLR4, and TLR10 influence bacterial infection, affecting susceptibility H. pylori to disease outcomes. Genomic DNA was extracted and genotypes of TLR1 (rs4833095), TLR2 (rs3804099 and rs3804100), TLR4 (rs10759932), and TLR10 (rs10004195) polymorphism were detected by the TagMan single-nucleotide epolymorphisms genotyping assay using the real-time PCR hybridization probe method...
May 15, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28368950/cervical-cancer-screening-and-subsequent-procedures-in-women-under-the-age-of-25-years-between-2007-and-2013-in-france-a-nationwide-french-healthcare-database-study
#8
Géric Maura, Christophe Chaignot, Alain Weill, François Alla, Isabelle Heard
Cervical cancer screening in young women may lead to the detection of lesions with a high potential for spontaneous regression and no benefit of surgery. French guidelines recommend initiating cervical cancer screening by the Pap test from the age of 25 years. To date, no French nationwide study has assessed cervical cancer screening in young women and the related subsequent work-up and surgical procedures among screen-positive women. Using data from the French national healthcare databases (around 50 million beneficiaries), annual and 3-year Pap test screening rates were calculated among women aged 15-24 years between 2007 and 2013...
May 10, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28471803/search-for-genetic-factor-association-with-cancer-free-prostate-specific-antigen-level-elevation-on-the-basis-of-a-genome-wide-association-study-in-the-korean-population
#9
Eun Kyung Choe, Young Lee, Jeong Yeon Cho, Seung Ho Choi, Boram Park, Jong-Eun Lee, Eun Young Cho
We investigated the genetic markers associated with elevated serum prostate-specific antigen (sPSA) levels to improve the predictive power of sPSA in screening for prostate cancer. A genome-wide association study was carried out among 4124 healthy Korean male adults using the Affymetrix Axiom Customized Biobank Genotyping Arrays for sPSA levels. A subgroup analysis for increased sPSA levels who underwent a prostate biopsy (n=64) was also carried out. We detected 11 single nucleotide polymorphisms (SNPs) near the Solute carrier family 45member 3, AGAP7P, MSMB, LOC101929917, and KLK3 genes associated with sPSA levels...
May 3, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28489708/muc1-muc5ac-and-muc6-polymorphisms-helicobacter-pylori-infection-and-gastric-cancer-a-systematic-review-and-meta-analysis
#10
Luca Giraldi, Maria B Michelazzo, Dario Arzani, Roberto Persiani, Roberta Pastorino, Stefania Boccia
The risk of Helicobacter pylori (HP) infection, as well as gastric cancer (GC), in association with genetic polymorphisms of gene encoding for mucins, has been investigated with contradictory results. We carried out this systematic review and meta-analysis to summarize the relationship between MUC1, MUC5AC, and MUC6 polymorphisms and HP infection, as well as GC risk. We searched MEDLINE, ISI Web of Science, Scopus bibliographic databases and the HuGE Navigator database. Odds ratios (ORs) and 95% confidence interval (CI) were calculated to assess the association between the genetic polymorphisms, and HP/GC risk...
May 1, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28418939/exploring-the-molecular-pathogenesis-and-biomarkers-of-high-risk-oral-premalignant-lesions-on-the-basis-of-long-noncoding-rna-expression-profiling-by-serial-analysis-of-gene-expression
#11
Hongcheng Jia, Xuan Wang, Zheng Sun
Oral premalignant lesions (OPLs) have malignant transformation potential, with no reliable markers available. This study aimed to assess molecular events to identify biomarkers that can reflect high-risk lesions as predictive factors to tailor clinical decision for patients on the basis of long noncoding RNAs (lncRNA) expression profiling by serial analysis of gene expression. The GSE31021 and GSE8127 datasets were downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) and lncRNAs were identified using the LIMMA package in R language...
April 24, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28403014/occupational-exposures-and-genetic-susceptibility-to-urinary-tract-cancers-a-systematic-review-and-meta-analysis
#12
Jovana Stojanovic, Sonja Milovanovic, Roberta Pastorino, Ivo Iavicoli, Stefania Boccia
This study aims to summarize the current knowledge on the relationship between genetic polymorphisms, occupational exposures, and urinary tract cancers. We searched MEDLINE, ISI Web of science, and SCOPUS online databases for all articles published in English language up to September 2016. A meta-analysis was performed to provide summary estimates for the association between a certain genetic polymorphism, occupational exposure and bladder cancer (BC) or kidney cancer (KC), when appropriate. Fifteen studies on BC and six on KC were deemed eligible for the review...
April 11, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28394804/risk-factors-prevalence-and-site-concordance-of-human-papillomavirus-in-high-risk-greek-men
#13
Savas Tsikis, Lea Hoefer, George Bethimoutis, Electra Nicolaidou, Vassilios Paparizos, Christina Antoniou, Leonidas Chardalias, Georgios-Emmanouil Stavropoulos, Shruti Sharma, Bradley C Long, Ibro Mujacic, Sabah Kadri, Jeremy P Segal, Larissa V Furtado, John Schneider, Angella Charnot-Katsikas
The aim of this study was to determine the risk factors, genotype-specific prevalence, and concordance of human papillomavirus (HPV) infections at three anatomical sites in a cohort of high-risk Greek men. Patients were recruited from sexually transmitted infection and HIV clinics in Athens. Samples were obtained from oral, penile, and anal sites of 294 study participants and HPV testing was performed on 882 samples using next-generation sequencing. Patients also completed a questionnaire assessing risk factors for infection...
April 7, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28379886/are-smokers-less-likely-to-seek-preventive-healthcare-measures-in-italy
#14
Giulia Carreras, Laura Iannucci, Giuseppe Costa, Elisabetta Chellini, Giuseppe Gorini
Smoking cessation is the key cancer and cardiovascular disease (CVD) prevention action for smokers; however, smokers can still benefit from earlier diagnosis. This study aims to investigate behaviours towards cancer and CVD prevention by smoking habits in Italy. The study relies on data from a large Italian population-based survey carried out in 2013 on a sample of 119 073 individuals. We studied the relationship between smoking habits and the participation in cancer (cervical, breast and colorectal) screening programmes, or CVD prevention (performing cholesterol, blood pressure and glycaemia exams) using a multilevel logistic regression model...
April 4, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28379885/recent-lung-cancer-mortality-trends-in-europe-effect-of-national-smoke-free-legislation-strengthening
#15
Jose L López-Campos, Miguel Ruiz-Ramos, Esteve Fernandez, Joan B Soriano
The impact of smoke-free legislation within European Union (EU) countries on lung cancer mortality has not been evaluated to date. We aimed to determine lung cancer mortality trends in the EU-27 by sex, age, and calendar year for the period of 1994 and 2012, and relate them with changes in tobacco legislation at the national level. Deaths by Eurostat in each European country were analyzed, focusing on ICD-10 codes C33 and C34 from the years 1994 to 2012. Age-standardized mortality rates (ASR) were estimated separately for women and men in the EU-27 total and within country for each one of the years studied, and the significance of changing trends was estimated by joinpoint regression analysis, exploring lag times after initiation of smoke-free legislation in every country, if any...
April 4, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28379884/parental-alcohol-consumption-and-risk-of-leukemia-in-the-offspring-a-systematic-review-and-meta-analysis
#16
Maria A Karalexi, Nick Dessypris, Thomas P Thomopoulos, Evangelos Ntouvelis, Maria Kantzanou, Andreas-Antonios Diamantaras, Maria Moschovi, Margarita Baka, Emmanuel Hatzipantelis, Maria Kourti, Sophia Polychronopoulou, Eftichia Stiakaki, Ana-M Mora, Victor Wunsch-Filho, Claire Infante-Rivard, Dimitrios Loutradis, Eleni Th Petridou
Parental alcohol consumption before and during pregnancy has been linked to adverse outcomes in the offspring including leukemogenesis. We, therefore, aimed to systematically assess and quantitatively synthesize published data on the association of paternal consumption during preconception and maternal consumption during pregnancy with leukemia risk in childhood (0-14 years). Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we searched PubMed (until February 2016) and the reference lists of the relevant studies...
April 4, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28379883/rheumatoid-arthritis-and-cancer-risk-bullet-operator-results-from-the-greek-european-prospective-investigation-into-cancer-and-nutrition-cohort
#17
Eleni Klinaki, Michail Katsoulis, Carlo La Vecchia, Antonia Trichopoulou
To investigate the relative risk of cancer development in rheumatoid arthritis (RA) patients in Greece after taking into consideration treatment modalities. The present analysis used data on the medical history of 26 331 participants in the Greek arm of the European Prospective Investigation into Cancer and Nutrition that were collected at enrollment and thereafter during active follow-up. A history of RA and of drug treatment for the disease, as reported at baseline examination, was linked to cases of cancer reported during follow-up...
April 4, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28368949/uptake-of-a-colorectal-cancer-screening-blood-test-in-people-with-elevated-risk-for-cancer-who-cannot-or-will-not-complete-a-faecal-occult-blood-test
#18
Erin L Symonds, Charles Cock, Rosie Meng, Stephen R Cole, Robert J L Fraser, Graeme P Young
Participation rates in colorectal cancer (CRC) screening programmes using faecal occult blood tests (FOBTs) are low. Nonparticipation is commonly attributed to psychosocial factors, but some medical conditions also prevent screening. These barriers might be partially overcome if a blood test for CRC screening was available. This study determined whether people who had always declined screening by FOBT would participate if offered a blood test. An audit of registrants within a personalized CRC screening programme was undertaken to determine the reasons for regular nonparticipation in FOBT...
March 31, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28368948/active-lifestyle-patterns-reduce-the-risk-of-colorectal-cancer-in-the-mecca-region-saudi-arabia-a-case-control-study
#19
Awfa Y Alazzeh, Firas S Azzeh
We carried out a case-control study to investigate the effects of some lifestyle patterns on the occurrence of colorectal cancer (CRC) in the city of Mecca, Saudi Arabia. Parameters included BMI, employment, family income, educational level, family size, exercise, cancer awareness, diabetes, and hypertension. Individuals of both groups (n=164 for control group, n=137 for CRC group) completed a questionnaire with the help of trained dietitians. Results showed that limited cancer awareness was found to increase the risk of CRC [odds ratio (OR)=49...
March 31, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28368947/female-reproductive-factors-exogenous-hormone-use-and-pancreatic-cancer-risk-the-japan-public-health-center-based-prospective-study
#20
Yvonne Teng, Eiko Saito, Sarah K Abe, Norie Sawada, Motoki Iwasaki, Taiki Yamaji, Taichi Shimazu, Shizuka Sasazuki, Manami Inoue, Shoichiro Tsugane
An association between female reproductive factors, exogenous hormone use, and pancreatic cancer risk has long been suggested in laboratory settings, but epidemiological findings remain mixed and inconclusive. Studies carried out on Asian populations are also limited. In this study, 45 617 women aged 40-69 years were followed for an average of 18.4 years in the Japan Public Health Center-based prospective cohort and 211 pancreatic cases were identified as of 31 December 2011. We applied multivariate-adjusted Cox proportional hazards regression models using age as a time-scale to assess the association between female reproductive factors (menstrual status, menarche age, menopause age, number of births, age at first birth, total years of fertility, history of breastfeeding) and exogenous hormone use with the incidence of pancreatic cancer through hazard ratios and confidence intervals...
March 31, 2017: European Journal of Cancer Prevention
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