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Cellular and Molecular Biology

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https://www.readbyqxmd.com/read/28145863/the-association-between-paraoxonase-1-gene-polymorphisms-and-polycystic-ovarian-syndrome
#1
H F Gu, M Mou, Z G Liang, C Sun, X Y Ren, Y B Xiao
Some studies investigated the association of paraoxonase 1 (PON1) polymorphisms with polycystic ovarian syndrome (PCOS) risk. However, the result was still inconsistent. The aim of this study was to investigate whether there is an association between the PON1 polymorphisms and PCOS risk. Electronic databases, such as PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) databases, were searched for identification of the studies. The associations between PON1 polymorphisms and PCOS risk was quantified using ORs with 95% CIs...
December 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28145862/vegf-mediated-signaling-in-oral-cancer
#2
REVIEW
X Lin, S Khalid, M Z Qureshi, R Attar, I Yaylim, I Ucak, A Yaqub, S Fayyaz, A A Farooqi, M Ismail
Increasingly it is being realized that oral cancer arises from genetic/epigenetic mutations, dysregulations of spatio-temporally controlled signal transduction cascades and loss of apoptosis. Epidemiological studies have provided a stronger association between tobacco use (chewed and smoked) and oral cancer. Nevertheless, alcohol has also gained attention as a significant risk factor, having a multiplicative synergistic cancer promoting effect with tobacco. Vascular Endothelial Growth Factor (VEGF) mediated signaling has gained limelight because of its instrumental role in endothelial cell proliferation, survival, invasion, migration, chemotaxis of bone marrow (BM)-derived progenitor cells, vasodilation and vascular permeability...
December 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28145861/molecular-talk-of-adipokines-in-dermatological-diseases
#3
REVIEW
S Aydin
Adipose tissue is not a passive tissue storing triglycerides, but one that releases hormones, enzymes, growth factors, and cytokines. Currently, known to release more than 600 adipokines, the adipose is an active tissue involved in energy homeostasis and serving paracrine, autocrine and endocrinal functions. Besides, some adipokines (irisin and ghrelin, for example) are synthesized in the sebaceous glands of the skin and play important roles in certain dermatological diseases. This review will provide a systemic overview of adipokines, focusing on their tissue and organ distribution, functions in biological systems, and roles in dermatological diseases...
December 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28145860/synergistic-antibacterial-effect-of-apigenin-with-%C3%AE-lactam-antibiotics-and-modulation-of-bacterial-resistance-by-a-possible-membrane-effect-against-methicillin-resistant-staphylococcus-aureus
#4
K Akilandeswari, K Ruckmani
Methicillin-resistant Staphylococcus aureus (MRSA) infections are easily spread among infected patients, where resistance has dramatically increased resulted in serious health issues. Therefore, there is a need to develop alternative natural or combination drug therapies. Apigenin (AP) is a natural poly phenolic flavonoid has been found to possess many beneficial biological actions. The aim of this study was to investigate the anti-MRSA efficacy and synergistic effect of apigenin (AP) and in combination with ampicillin (AM) and ceftriaxone (CEF)...
December 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28145859/phytochemical-properties-of-iranian-organic-saffron-stigma-antioxidant-anticancer-and-apoptotic-approaches
#5
M A Behdani, R Hoshyar
Agronomic and environmental factors affect quality and quantity of constituents in Saffron.  In this study, we compared chemical and antioxidant compounds of organic (OS) and inorganic (IOS) stigma of saffron and evaluated their anti-proliferative and apoptosis effects on cancer cells. Total antioxidant capacity of both saffron were characterized by FRAP, DPPH and Folin-Ciocalteu. HPLC and MTT methods were used to assay the amount of their secondary metabolites and anticancer effects, respectively. The expression of two apoptosis-related genes in treated cells evaluated by quantitative Real Time-PCR analysis...
December 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28145858/analysis-of-serum-calcium-magnesium-and-parathyroid-hormone-in-neonates-delivered-following-preeclampsia-treatment
#6
S Vahabi, M Zaman, B Farzan
Due to the approximate clinical and biochemical manifestations of calcium and magnesium disturbances, with regard to the regulatory effects of parathyroid hormone (PTH), this present study is designed to analyze serum calcium (Ca), magnesium (Mg), and (PTH) at the time of birth, 24 hours afterwards in newborns after the mother has been treated with Mg-sulfate. We registered 86 term and preterm neonates (43 in each group) using simple census method delivered through vagina to preeclampsia pregnant women treated with Mg-sulfate immediately before birth in Khoramabad Asali Hospital, Iran...
December 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28145857/cytotoxicity-study-of-benzo-a-pyrene-on-blood-cells-of-wistar-rat-in-vitro
#7
J Zhang, Y Liu, S-Z Wei
The effect of benzo[a]pyrene (BaP) on Wistar rat lymphocyte activity, lymphocyle membrane integrity and erythrocytes hemolysis were examined using the MTT assay, the release of the lactate dehydrogenase (LD) and the hemoglobin release respectively in vitro. The results showed that lymphocyte activity had no remarkable response to BaP after a low dose of exposure. But the membrane change was found after higher dose of BaP exposure, and the significant release of LD was observed. The release of LD increased with exposure time prolonging and exposure dose increasing...
December 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28145856/class-i-integron-and-%C3%AE-lactamase-encoding-genes-of-multidrug-resistance-salmonella-isolated-from-pigeons-and-their-environments
#8
S Yousef, R Mamdouh
Seroprevalence of Salmonella spp. was investigated in pigeon and its surrounding environment of Sharkia province, Egypt. Samples were randomly collected from fifty freshly dead squabs, forty freshly dead adults pigeons, sixty diseased adult pigeons and 100 apparently healthy adult pigeons. Bacterial isolates were tested for their susceptibility to 17 different antimicrobial discs, by using the disc diffusion method. The bacterial isolates were tested for Class I and β-lactamase encoding genes by using PCR...
December 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28145855/association-between-gpx1-pro189leu-polymorphism-and-the-occurrence-of-bladder-cancer-in-morocco
#9
K Hadami, R Ameziane El Hassani, A Ameur, N Dakka, M Abbar, A Al Bouzidi, M Attaleb, M El Mzibri
Worldwide, Bladder cancer is the most frequent male malignancy. It is the third most common male malignancy in Morocco. The risk factors for developing bladder cancer are multiples including dietary conditions, environmental exposure and oxidative stress. GPX1 gene encoding for the human cellular antioxidant enzyme glutathione peroxidase1 is a key factor in the cell detoxification process. GPX1 Pro198Leu polymorphism is associated with a decrease of enzyme activity and may contribute to bladder cancer susceptibility...
December 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28145854/effects-of-matrix-types-on-formation-and-transformation-of-energy-accumulating-substances-in-enhanced-biological-phosphorus-removal-ebpr
#10
D Li, Z Fang, X Long, R Tang, S Di
Enhanced biological phosphorus removal (EBPR) has been widely used in wastewater treatment. In this study, a laboratory investigation of activated sludge in A/O-SBR reactor was conducted to probe the effects of the matrix types on EBPR polyphosphate, intracellular polysaccharide, polyhydroxyalkanoates (PHA) formation and transformation. There is a decrease in anaerobic condition and an increase in aerobic condition for the intracellular glycogen of sodium propionate matrix and sodium acetate matrix. While the intracellular glycogen of glucose matrix shows a decreasing tendency in both anaerobic and aerobic reaction process...
December 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28145853/over-expression-of-brain-derived-neurotrophic-factor-in-mesenchymal-stem-cells-transfected-with-recombinant-lentivirus-bdnf-gene
#11
X Zhang, J Zhu, K Zhang, T Liu, Z Zhang
This study was aimed at investigating the expression of brain-derived neurotrophic factor (BDNF) in mesenchymal stem cells (MSCs) modified with recombinant lentivirus bearing BDNF gene. Lentivirus vectors bearing BDNF gene were constructed. MSCs were isolated from rats and cultured. The lentiviral vectors containing BDNF gene were transfected into the MSCs, and BDNF gene and protein expressions were monitored with enhanced green fluorescent protein (EGFP). RT-PCR and Western blot were used to measure gene and protein expressions, respectibvely in MSCs, MSCs-EGFP and MSCs-EGFP-BDNF groups...
December 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28145852/safranal-prevents-rotenone-induced-oxidative-stress-and-apoptosis-in-an-in-vitro-model-of-parkinson-s-disease-through-regulating-keap1-nrf2-signaling-pathway
#12
P-K Pan, L-Y Qiao, X-N Wen
Safranal, a major constituent of saffron, possesses antioxidant and anti-apoptotic properties showing considerable neuroprotective effects. However, whether safranal shows therapeutic effect on Parkinson's disease (PD) remains unknown. In this study, we aimed to investigate the potential effect of safranal on PD using an in vitro model of PD induced by rotenone. We found that safranal significantly inhibited rotenone-induced cell death in a dose-dependent manner. Moreover, safranal also markedly suppressed the reactive oxygen species (ROS) generation and cell apoptosis induced by rotenone...
December 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28145851/the-influence-of-dietary-antioxidant-on-ovarian-eggs-and-levels-of-vitamin-e-c-a-astaxanthin-%C3%AE-carotene-and-oxidative-stres-in-tissues-of-astacus-leptodactylus-eschscholtz-during-reproduction
#13
O Barim-Oz, H Sahin
The experiment was conducted to determine the most effective antioxidant (among the vitamin E (VE), vitamin C (VC), vitamin A (VA), astaxanthine (AX), β-carotene (βC)) on the ovarian egg number and size, level of VE, VC, VA, AX, βC and oxidative stress (as malondialdehyde (MDA)) in the hepatopancreas, ovarian, gills and muscle tissue during ovarian development of Astacus leptodactylus. One control (C) and five experimental diets (EE, EC, EA, EAX and EβC) were prepared. The EE, EC, EA, EAX and EβC groups were formed by added 150 mg kg-1 VE, 200 mg kg-1 VC, 240 mg kg-1 VA, 200 mg kg-1 AX and 200 mg kg-1 βC to diet C, respectively...
December 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28040068/association-between-alpha-adducin-gene-rs4963-polymorphism-and-hypertension-risk-in-asian-population-a-meta-analysis
#14
Y-L Qu, C-M Wu, L-X Zhang, B-L Wen, X Zhang, C Ma, X-Y Yan, H-B Cui, D-M Wang, Y-R Ji
Some studies investigated the association between ADD1 rs4963 polymorphism and hypertension risk. However, the results remained inconclusive. Thus, we performed a meta-analysis. Published reports were searched in PubMed and Google Scholar. The strength of association was assessed by calculating odds ratios (OR) and 95% confidence interval (CI). Twelve studies with 5097 cases and 5937 controls were conducted in this study. Individuals with ADD1 rs4963 polymorphism showed an increased hypertension risk (OR = 1...
November 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28040067/type-2-diabetes-and-mental-disorders-a-plausible-link-with-inflammation
#15
REVIEW
B Hajebrahimi, A Kiamanesh, A A Asgharnejad Farid, G Asadikaram
Mental disorders including depression and anxiety are the prevalent human diseases which are associated with several metabolic and non-metabolic diseases. Recent investigations demonstrated that the mental disorders can be considered as the potential inducers/stimulators of chronic inflammation. Based on the fact that chronic inflammation is a main cause of human diseases, hence, a hypothesis has been raised to explore the interaction between mental disorders and inflammation related metabolic diseases. Type 2 diabetes (T2D), as a complicated metabolic disorder, is associated with inflammation and also mental disorders...
November 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28040066/effects-of-ambroxol-hydrochloride-on-concentrations-of-paclitaxel-and-carboplatin-in-lung-cancer-patients-at-different-administration-times
#16
J Li, W Yi, P Jiang, R Sun, T Li
Our previous preliminary study revealed a synergistic effect of ambroxol hydrochloride with chemotherapeutic agents such as paclitaxel and carboplatin in lung cancer. However, the optimal conditions such as administration time and drug concentration of ambroxol hydrochloride to achieve the maximum synergistic effect remained unclear. Therefore, concentration changes of the chemotherapy drugs paclitaxel and carboplatin in the sputum were observed after ambroxol hydrochloride administration at different times in order to determine the most effective time frame of ambroxol hydrochloride administration...
November 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28040065/effects-of-pax9-and-msx1-gene-variants-to-hypodontia-tooth-size-and-the-type-of-congenitally-missing-teeth
#17
D Kirac, F Eraydin, T Avcilar, K Ulucan, F Özdemir, A I Guney, E Ç Kaspar, E Keshi, T Isbir
ooth agenesis, affecting up to 20% of human population, is one of the most common congenital disorder. The most frequent form of tooth agenesis is known as hypodontia, which is characterized by the absence of one to five permanent teeth excluding third molars. It was considered that hypodontia is especially related with gene mutations which play role in tooth formation. Additionally mutations in PAX9 and/or MSX1 have been identified as the defects responsible for missing permanent molars and second premolars...
November 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28040064/klf5-is-involved-in-regulation-of-ifitm1-2-and-3-genes-during-h5n1-virus-infection-in-a549-cells
#18
H-F Wang, L Chen, J Luo, H-X He
The interferon-induced transmembrane (IFITM) proteins usually protect cells from many virus infections by viral entry and replication. Thus, the present study aimed to identification novel regulation factors of IFITM genes. Our data showed up-regulation of IFITM1, IFITM2, and IFITM3 genes in A549 by H5N1 virus infection. However, IFITM1 was not affected, IFITM2 and IFITM3 increases expression following different concentration H5N1 virus infection in HEK293T cells. This is the first time to find differences of IFITM1 transcription in different cells with the H5N1 virus infection...
November 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28040063/pivotal-role-of-glutathione-depletion-in-enos-uncoupling-of-lps-treated-huvecs
#19
L Chen, E Liu, D Cao, S Li, C Xiao, M Xiong, Q Kou
The present study investigated the relationship between uncoupling of endothelial nitric oxide synthase (eNOS) and vascular endothelial cell (VEC) oxidative stress (OS) during sepsis and the role of eNOS glutathionylation in eNOS uncoupling of septic VECs. Human umbilical vein endothelial cells (HUVECs) cultured in vitro (EA.hy269 cell line) were incubated with Dulbecco's modified Eagle's medium (DMEM) (normal control group), lipopolysaccharide (LPS) (sepsis group), 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) (glutathionylation group), and LPS+ dithiothreitol (DTT) (deglutathionylation sepsis group)...
November 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28040062/influences-of-dietary-omega-3-fatty-acids-on-haematologic-and-immunologic-changes-in-rainbow-trout-milked-regularly
#20
M E Yonar, K Koprucu
In this study, it was examined the effects of dietary omega-3 fatty acids on the haematocrit (Ht), haemoglobin (Hb), mean corpuscular haemoglobin (MCH), total protein (TP) and total immunoglobulin (TI) values, erythrocyte (RBC) and leucocyte (WBC) counts, mean corpuscular volume (MCV), mean corpuscular haemoglobin concentration (MCHC), phagocytic index (PI) and nitroblue tetrazolium (NBT) activity in rainbow trout (Oncorhynchus mykiss) milked regularly. For this aim, one control and two experimental diets were prepared as isonitrogenous and isocaloric...
November 30, 2016: Cellular and Molecular Biology
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