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Cellular and Molecular Biology

Babita Patni, Harish Chandra, Abhay Prakash Mishra, Sudhir Kumar Guru, Sara Vitalini, Marcello Iriti
The intensive use of pesticides with low biodegradability and high persistence in soil, surface and ground waters, represents a considerable environmental risk, especially under high weed pressure conditions. Furthermore, the number of herbicide-resistant weeds is increasing. Against this background, the investigation of alternative weed control strategies has taken on considerable importance. Among these, allelopathy as a negative effect of one plant on another due to the direct or indirect (including microorganisms) release of chemicals in the environment can be a useful tool for the integrated management of weeds in agroecosystems...
June 25, 2018: Cellular and Molecular Biology
Abhay Prakash Mishra, Mehdi Sharifi-Rad, Mohammad Ali Shariati, Yahia N Mabkhot, Salim S Al-Showiman, Abdur Rauf, Bahare Salehi, Milan Župunski, Majid Sharifi-Rad, Poonam Gusain, Javad Sharifi-Rad, Hafiz Ansar Rasul Suleria, Marcello Iriti
Medicinal and food plants as well as their bioactive fractions have been used by diverse human cultures since ancient times. These plants provide multiple health benefits because of the presence of a plethora of phytochemicals including phenylpropanoids, isoprenoids, alkaloids, sulphated compounds, peptides and polysaccharides that are responsible for various biological activities such as anticancer, antioxidant, antifungal, antibacterial, anti-dysenteric, anti-inflammatory, antiulcer, anti-hypertensive and anticoagulant properties...
June 25, 2018: Cellular and Molecular Biology
Federico Scotti, Sem Decani, Andrea Sardella, Marcello Iriti, Elena Maria Varoni, Giovanni Lodi
Post-operative management of patients receiving oral biopsy includes the control of edema, pain, infection, and re-epithelization at the surgical site. This clinical study investigates the topical use of a bioadhesive gel, containing essential oils, to promote wound healing and prevent post-operative pain and infection, avoiding the need for surgical suture and chlorhexidine applications. Ten patients, who needed to receive oral biopsies (≤6 mm in diameter) for the diagnosis of mucosal oral lesions, were enrolled...
June 25, 2018: Cellular and Molecular Biology
Anna Abdolshahi, Sahar Naybandi-Atashi, Mojtaba Heydari-Majd, Bahare Salehi, Farzad Kobarfard, Seyed Abdulmajid Ayatollahi, Athar Ata, Giulia Tabanelli, Mehdi Sharifi-Rad, Chiara Montanari, Marcello Iriti, Javad Sharifi-Rad
Doogh is a dairy drinkable fermented product, whose shelf-life and quality is mostly affected by bacteria such as Staphylococcus spp.. This study investigated the antibacterial activity of essential oils (EOs) from Thymus vulgaris L., Mentha piperita L. and Ziziphora tenuior L., alone or in combination, against Staphylococcus aureus in industrial doogh. A three-level and three-variable face centered central composite design experiment was used. Results showed that EOs significantly inhibited S. aureus growth after 1 and 7 days of storage...
June 25, 2018: Cellular and Molecular Biology
Abhay P Mishra, Sarla Saklani, Mehdi Sharifi-Rad, Marcello Iriti, Bahare Salehi, Vineet Kumar Maurya, Abdur Rauf, Luigi Milella, Sadegh Rajabi, Navid Baghalpour, Javad Sharifi-Rad
Uttarakhand Himalayan region holds Asteraceae or Compositae as the largest family of flowering, medicinal and aromatic plants. Species belonging to this family rises from low altitude to the alpine region. Among Asteraceae, Saussurea obvallata (DC.) Edgew. is widely used in several indigenous systems of medicine. Flowers, leaves and rhizomes of S. obvallata are used for several traditional, religious, therapeutic and ornamental purposes. Aim of this study was to determine the chemical composition and antibacterial efficacy of petroleum ether extract (PEE) of S...
June 25, 2018: Cellular and Molecular Biology
Javad Sharifi-Rad, Mehdi Sharifi-Rad, Bahare Salehi, Marcello Iriti, Amir Roointan, Dima Mnayer, Azam Soltani-Nejad, Azam Afshari
With the appearance of new disorders along with inability of some conventional therapies for the treatment of diseases without any side effects, the discovery of safe and efficient therapeutic agents is of utmost importance in the medical area. In this context, medicinal plants as promising therapeutic candidates can provide a reliable and efficient profile. Since free radicals are at the center of various disorder pathways, reducing their production or complete removal of these chemical species could be advantageous for prevention and treatment of many diseases...
June 25, 2018: Cellular and Molecular Biology
Javad Sharifi-Rad, Ghazaleh S Tayeboon, Fereshteh Niknam, Majid Sharifi-Rad, Maryam Mohajeri, Bahare Salehi, Marcello Iriti, Mehdi Sharifi-Rad
Veronica persica (Persian speedwell) is a flowering plant local to Eurasia. In this study, several analyses were done to discover the antimicrobial and scolicidal activities and acetyl cholinesterase (AChE), tyrosinase (TYR), lipoxygenase (LOX), and xanthine oxidase (XO) inhibitory activities of V. persica extract. The results presented that B. subtilis was the most susceptible to the extract (MIC = 40.3 μg/mL), while P. aeruginosa was the most resistant strain (MIC = 250.9 μg/mL) among all bacteria evaluated...
June 25, 2018: Cellular and Molecular Biology
Javad Sharifi-Rad, Amir Roointan, William N Setzer, Mehdi Sharifi-Rad, Marcello Iriti, Bahare Salehi
Leishmania major is an intracellular parasite generally responsible for cutaneous leishmaniasis (CL), one of the most encountered skin diseases especially in Pakistan, Iran, Iraq, and Saudi Arabia. Current treatment options are not ideal, due to unwanted side effects and increasing resistance and availability is often limited in developing countries. Medicinal plants continue to attract attention because of their beneficial effects in the prevention or/and accelerating the healing process of various diseases...
June 25, 2018: Cellular and Molecular Biology
Abhay P Mishra, Sarla Saklani, Bahare Salehi, Versha Parcha, Mehdi Sharifi-Rad, Luigi Milella, Marcello Iriti, Javad Sharifi-Rad, Manjoosha Srivastava
The present study investigated antioxidant and antibacterial activities of 5 different extracts and derived fractions from the S. nepalense tubers. Identification of the most active fractions, their phytochemical characterization, total phenolic and flavonoid contents, and biological activities were also evaluated. Petroleum ether, chloroform, ethyl acetate, methanol, water extracts and methanol fractions were screened for their antibacterial activity at 10, 50 and 100 mg/mL doses against ten Gram-negative and Gram-positive bacterial strains by disc diffusion method...
June 25, 2018: Cellular and Molecular Biology
Leila Monjazeb Marvdashti, Anna Abdolshahi, Sara Hedayati, Mehdi Sharifi-Rad, Marcello Iriti, Bahare Salehi, Javad Sharifi-Rad
Pullulan is an important polysaccharide with several potential applications in food science, pharmaceutical and cosmetic industries, but high costs of pullulan production are the main limitation for commercial utilization. Therefore, a cost-effective process for pullulan production was developed using fig syrup as an exclusive nutrient source. In particular, the feasibility of using low quality fig syrup as a supplemental substrate for pullulan gum production by Aureobasidium pullulans was investigated. Fermentation was carried out over a range of fig syrup and sucrose degrees Brix (5-15%)...
June 25, 2018: Cellular and Molecular Biology
Mehdi Sharifi-Rad, Bahar Salehi, Javad Sharifi-Rad, William N Setzer, Marcello Iriti
Leishmaniasis is a neglected parasitic protozoal disease that affects approximately 12 million people and represents a public health problem in Iran. The objectives of this study were to obtain the essential oil (EO) from Pulicaria vulgaris Gaertn. growing in Iran and to carry out in-vitro antileishmanial screening of the EO against promastigotes of Leishmania major and Leishmania infantum. The EO from the aerial parts of P. vulgaris was extracted by hydrodistillation. Serial dilutions of the EO were screened for in-vitro antileishmanial activity using 96-well microtiter plates...
June 25, 2018: Cellular and Molecular Biology
Javad Sharifi-Rad, Marcello Iriti, William N Setzer, Mehdi Sharifi-Rad, Amir Roointan, Bahare Salehi
The lack of an effective anti-viral agent and the emergence of drug-resistant strains dictate a real need for discovery of novel therapies able to ameliorate viral infections. In this regards, medicinal plants and natural products offer safe and inexpensive platforms for discovery of efficient and novel anti-viral agents. We have investigated the potential anti-viral activities of Veronica persica Poir.  as a medicinal plant against herpes simplex viruses (HSVs). In vitro screening of the ethanol plant extract against HSV-1 and HSV-2 infected Vero cells revealed the extract to show a dose-dependent inhibitory activity against both virus strains...
June 25, 2018: Cellular and Molecular Biology
Agata Kabała-Dzik, Anna Rzepecka-Stojko, Robert Kubina, Marcello Iriti, Robert D Wojtyczka, Ewa Buszman, Jerzy Stojko
Breast cancer is one of the most common causes of mortality in women. Flavonoids, among other compounds, are bioactive constituents of propolis. In this comparative study, we investigated the effects of flavonoids apigenin (API), genistein (GEN), hesperidin (HES), naringin (NAR) and quercetin (QUE) on the proliferation, apoptosis, and cell cycle of two different human cancer cells - MDA-MB-231, estrogen-negative, and MCF-7, estrogen-positive receptor breast carcinoma cells. Many cytotoxic reports of flavonoids were performed by MTT assay...
June 25, 2018: Cellular and Molecular Biology
Wee Chee Lee, Siti Safiah Mokhtar, Seetha Munisamy, Sahran Yahaya, Aida Hanum Ghulam Rasool
Diabetes mellitus is an epidemic that is gaining global concern. Chronic hyperglycemia in diabetes induces the excess production of free radicals. The deleterious effects of excess free radicals are encountered by endogenous antioxidant defense system. Imbalance between free radicals production and antioxidants defense mechanisms leads to a condition known as "oxidative stress". Diabetes mellitus is associated with augmented oxidative stress that induced micro- and macrovascular complications, which presents a significant risk for cardiovascular events...
May 30, 2018: Cellular and Molecular Biology
Erdoğan Dadaş, Muhsin Aydın
Overexpression of Hox transcript antisense intergenic RNA (HOTAIR), a long non-coding RNA (lncRNA), is associated with tumorigenesis and multiple cancer types including lung cancer. In this study, the association between two HOTAIR single nucleotide polymorphisms (SNPs) (rs12826786 and rs1899663) on the risk and clinical characteristics of lung cancer in a Turkish population was investigated. We genotyped HOTAIR rs12826786 and rs1899663 polymorphisms in 180 Turkish people including 87 lung cancer patients (71 males and 16 females) and 93 age-matched healthy controls (67 males and 26 females) by a TaqMan real-time polymerase chain reaction method...
May 30, 2018: Cellular and Molecular Biology
Alireza Zebarjadi, Samaneh Kazem, Danial Kahrizi
Arctium lappa L. (Burdock) is an important plant with various pharmacological effects. According to the importance of this plant, optimization of its tissue culture will lead to more investigation and application of it. The aim of this study was to develop protocols for callus induction and shoot regeneration of A.  lappa. In order to optimize of tissue culture in A. lappa, callus induction, indirect regeneration and direct regeneration were carried out in factorial experiment based on Completely Randomized Designs (CRDs)...
May 30, 2018: Cellular and Molecular Biology
Mehdi Bagheri, Mozhgan Fazli, Sara Saeednia, Aylar Kor, Naghmeh Ahmadiankia
The standard treatment for triple-negative breast cancer (TNBC) is chemotherapy, which is highly toxic to patients; thereby, there is a need to identify safer and more effective therapeutic approaches. Medicinal plants constitute a common alternative for cancer treatment. Pomegranate is a well-known fruit in this context, but its antimetastatic property has not been extensively studied. As breast cancer-related deaths from TNBC are mainly due to metastasis, the present study was designed to investigate the antimigratory effect of pomegranate peel extract (PPE) on TNBC cells...
May 30, 2018: Cellular and Molecular Biology
Yi-Hua Zhu, Zhen-Ming Pei
Therapeutic target transient receptor potential vanilloid-4 (TRPV-4) is frequently applied in endotoxemia research. It has been reported that HC067047, an inhibitor of TRPV-4, mitigated LPS-induced injury. However, the inhibition of TRPV-4 with HC06047 did not attenuate LPS-induced symptoms and exaggerated pathology. This study was carried with a view to unravelling the reason(s) behind these conflicting results. Different doses of the inhibitor were used in the same degree of sepsis, and their effects were determined through assays for sepsis-related physiological indicators such as endothelial injury markers, coagulation index, organ damage indicators, inflammatory factor levels, and cell apoptosis...
May 30, 2018: Cellular and Molecular Biology
Fatemeh Ghaffarian, Mojtaba Hedayati, Hadi Sedigh Ebrahim-Saraie, Zahra Atrkar Roushan, Ali Mojtahedi
The emergence of extended-spectrum beta-lactamases (ESBL) producing strains become a great concern, because few antimicrobial agents remain active against them. Due to the lack of data on the genotyping characteristics and antibiotics resistance of clinical isolates of Klebsiella pneumoniae in the north of Iran, this study aimed to determine the occurrence of ESBL-producing isolates and their molecular characteristics in order to analyses their epidemiological relationships. This cross-sectional study performed on 60 K...
May 30, 2018: Cellular and Molecular Biology
Liu Shuaichen, Wang Guangyi
Hepatocellular carcinoma (HCC) is a common cancer and the sixth most lethal malignancy in the world. We chose gene expression profile of GSE14520 from GEO database aiming to find key genes that affect HCC progression. 22 paired tumor and non-tumor samples were included in this analysis. Differentially expressed genes (DEGs) between tumor and non-tumor were selected using GEO2R. Gene ontology (GO) enrichment and protein-protein interaction (PPI) of the DEGs were done using Metascape. There were 357 DEGs, including 70 up-regulated genes and 287 down-regulated genes...
May 30, 2018: Cellular and Molecular Biology
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