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Cellular and Molecular Biology

Y H Lee, S-C Bae
This study systemically reviewed evidence regarding the relationship between circulating blood transforming growth factor-β1 (TGF-β1) levels and systemic lupus erythematous (SLE) and rheumatoid arthritis (RA), and associations between TGF-β1 polymorphisms and susceptibility to SLE and RA.  We conducted a meta-analysis on the serum/plasma TGF-β1 levels in SLE and RA patients and healthy controls, and the associations between TGF-β1 +869 T/C, +915 C/G, and -509 T/C polymorphisms and SLE or RA risk. Twenty-eight studies were considered in this meta-analysis...
February 22, 2017: Cellular and Molecular Biology
O Ozcelik, S Algul
The association between hyperglycaemia and serum nitric oxide (NO) levels has not yet been fully clarified. Thus, it was aimed to evaluate the concentration of NO metabolites (nitrate, nitrite) in diabetic patients and to find the relationship between hyperglycaemia and serum NO levels in diabetic and prediabetic patients, and control groups. In this study, 100 subjects were divided into 3 groups: healthy control (n=20), prediabetic (n=40) and diabetic (n=40). Glycemic control was assessed using glycated hemoglobin (HbA1c)...
February 22, 2017: Cellular and Molecular Biology
F Mohammadian, A Eatemadi, H Daraee
Dysfunction of inner ear can result in from several disease procedures and introduce a possibility for therapeutic intervention. The existence of a blood-cochlear obstacle and round window membrane restricts direct access into the inner ear and following inner ear drug, gene, protein and cell delivery. Several strategies have designed to increase drug delivery to the inner ear. One of main particles for inner ear drug delivery is liposome. Here we reviewed the application of liposomes in inner ear drug delivery...
January 30, 2017: Cellular and Molecular Biology
F Mohammadian, A Eatemadi, H Daraee
Over 278 million of people worldwide suffers from hearing loss, and this disease has significant detrimental effects emotionally and economically on individuals and the society in totality. Treatment using cochlear implant dramatically improve the perception, and production of speech, as well as the patient quality of life, with the different sensorineural hearing loss (SNHL). Yet, there are some challenges faced by a cochlear implant. In this review, we propose the regeneration of spiral ganglion neurons which is an interface neuron using human amniotic fluid mesenchymal stem cells (hAFMSCs), due to its high pluripotency potentials, this stem cell source can regenerate the spiral ganglion and this in-turn will bring back the inner ear hair-cells to functionality...
January 30, 2017: Cellular and Molecular Biology
G Gorgisen, I M Gulacar, O N Ozes
Insulin Receptor Substrate (IRS) proteins are the main cytoplasmic adaptor molecules involved in transducing extracellular signals from receptors to downstream proteins. This protein family have pivotal roles on maintenance, distribution and regulation of signaling networks. Since IRS1/2 interact with and transmits signals from the receptors of insulin, Insulin Like Growth Factor 1 (IGF1), prolactin, growth hormone (GH), leptin, Vascular Endothelial Growth Factor (VEGF), TrkB, ALK and integrins this promoted scientist to think that IRS1 may have functions in cell proliferation, tumorigenesis and metastasis...
January 30, 2017: Cellular and Molecular Biology
Z Qiao, Y Chen, Y Zhang, Q Niu
Deep sea fish oil mainly includes polyunsaturated fatty acid, which is usually used as health products and applied for prevention of cardiovascular and cerebrovascular diseases. However, there are only a few studies investigating the diabetes induced nerve injury till now. We established the diabetic model by using the 8-week old inbred male mice, and assumed that fish oil had a certain therapeutic effect on related neurosensory impairment and oxidative stress. Mice were divided into group A (diabetic mice induced by streptozotocin (STZ) and treated with fish oil), group B (diabetic mice) and group C (normal mice, without STZ treatment)...
January 30, 2017: Cellular and Molecular Biology
J Yuan, X Liu, Y Chen, Y Zhao, P Liu, L Zhao, W Han
To explore the effect of SOX2 on osteogenic differentiation of dental pulp stem cells (DPSCs) and to develop a new method for facilitating osteogenic differentiation of DPSCs. SOX2-overexpressing human DPSCs (DPSCs-SOX2) were established through retrovirus infection. Differentiation was induced with osteogenic differentiation medium and further evaluated by alkaline phosphatase (ALP) staining and qPCR. Following the differentiation procedure, the mechanism of SOX2 on osteogenic differentiation of DPSCs was analyzed using genome RNA microarray and flow cytometry...
January 30, 2017: Cellular and Molecular Biology
M Kalani, H Hodjati, A GhamarTalepoor, A Samsami Dehaghani, M Doroudchi
Given that the basic mechanism of the effect of Helicobacter (H.) pylori in the induction of atherosclerosis remains unknown and regarding the regulatory role of micro RNAs (miRNAs) in endothelial cell (EC) functions, we aimed to investigate the effect of H. pylori on the expression of miRNAs involved in atherosclerosis (atheromiRs) and their correlation with apoptosis in human umbilical vein EC (HUVEC). HUVECs were treated with different cytotoxin associated gene A (CagA) positive and negative H. pylori derived products, then the levels of apoptosis and miR-21, 92a, 155 and 663 were measured using flowcytometry and real time-PCR methods, respectively...
January 30, 2017: Cellular and Molecular Biology
G A Duran-Rehbein, J C Vargas-Zambrano, A Cuéllar, C J Puerta, J M Gonzalez
Trypanosoma cruzi can compromise the human central nervous system (CNS) during acute infection or reactivation in immune-suppressed hosts. Astrocytes have been identified as targets of T. cruzi's CNS infection in humans. Despite a high degree of parasitism and cellular lysis by T. cruzi in vitro the number of astrocytoma cells did not change when compared to uninfected cultures. This work evaluated cellular proliferation, changes in Major Histocompatibility Complex (MHC) expression as a reflection of antigen processing, and cytokine (IL-6 & IL-8) secretion in a human astrocytoma cell line exposed to a trypomastigote-derived antigen...
January 30, 2017: Cellular and Molecular Biology
U İspir, M Kirici, M E Yonar, S Mişe Yonar
Formalin bath treatments are widely used to control of parasitic infections in aquaculture. However, effects of formaldehyde on the lipid peroxidation and antioxidant system were not still need elucidation. Fish were exposed to formalin at doses of 50, 100 and 200 ppm for 1 h. Fish were then left to depurate for 24 h in formalin-free water. At the end of the test, whole bodies were isolated and homogenized to measured malondialdehyde (MDA) and reduced glutathione  (GSH) levels and catalase (CAT) and glutathione peroxidase (GPx ) activities...
January 30, 2017: Cellular and Molecular Biology
H F Gu, M Mou, Z G Liang, C Sun, X Y Ren, Y B Xiao
Some studies investigated the association of paraoxonase 1 (PON1) polymorphisms with polycystic ovarian syndrome (PCOS) risk. However, the result was still inconsistent. The aim of this study was to investigate whether there is an association between the PON1 polymorphisms and PCOS risk. Electronic databases, such as PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) databases, were searched for identification of the studies. The associations between PON1 polymorphisms and PCOS risk was quantified using ORs with 95% CIs...
December 30, 2016: Cellular and Molecular Biology
X Lin, S Khalid, M Z Qureshi, R Attar, I Yaylim, I Ucak, A Yaqub, S Fayyaz, A A Farooqi, M Ismail
Increasingly it is being realized that oral cancer arises from genetic/epigenetic mutations, dysregulations of spatio-temporally controlled signal transduction cascades and loss of apoptosis. Epidemiological studies have provided a stronger association between tobacco use (chewed and smoked) and oral cancer. Nevertheless, alcohol has also gained attention as a significant risk factor, having a multiplicative synergistic cancer promoting effect with tobacco. Vascular Endothelial Growth Factor (VEGF) mediated signaling has gained limelight because of its instrumental role in endothelial cell proliferation, survival, invasion, migration, chemotaxis of bone marrow (BM)-derived progenitor cells, vasodilation and vascular permeability...
December 30, 2016: Cellular and Molecular Biology
S Aydin
Adipose tissue is not a passive tissue storing triglycerides, but one that releases hormones, enzymes, growth factors, and cytokines. Currently, known to release more than 600 adipokines, the adipose is an active tissue involved in energy homeostasis and serving paracrine, autocrine and endocrinal functions. Besides, some adipokines (irisin and ghrelin, for example) are synthesized in the sebaceous glands of the skin and play important roles in certain dermatological diseases. This review will provide a systemic overview of adipokines, focusing on their tissue and organ distribution, functions in biological systems, and roles in dermatological diseases...
December 30, 2016: Cellular and Molecular Biology
K Akilandeswari, K Ruckmani
Methicillin-resistant Staphylococcus aureus (MRSA) infections are easily spread among infected patients, where resistance has dramatically increased resulted in serious health issues. Therefore, there is a need to develop alternative natural or combination drug therapies. Apigenin (AP) is a natural poly phenolic flavonoid has been found to possess many beneficial biological actions. The aim of this study was to investigate the anti-MRSA efficacy and synergistic effect of apigenin (AP) and in combination with ampicillin (AM) and ceftriaxone (CEF)...
December 30, 2016: Cellular and Molecular Biology
M A Behdani, R Hoshyar
Agronomic and environmental factors affect quality and quantity of constituents in Saffron.  In this study, we compared chemical and antioxidant compounds of organic (OS) and inorganic (IOS) stigma of saffron and evaluated their anti-proliferative and apoptosis effects on cancer cells. Total antioxidant capacity of both saffron were characterized by FRAP, DPPH and Folin-Ciocalteu. HPLC and MTT methods were used to assay the amount of their secondary metabolites and anticancer effects, respectively. The expression of two apoptosis-related genes in treated cells evaluated by quantitative Real Time-PCR analysis...
December 30, 2016: Cellular and Molecular Biology
S Vahabi, M Zaman, B Farzan
Due to the approximate clinical and biochemical manifestations of calcium and magnesium disturbances, with regard to the regulatory effects of parathyroid hormone (PTH), this present study is designed to analyze serum calcium (Ca), magnesium (Mg), and (PTH) at the time of birth, 24 hours afterwards in newborns after the mother has been treated with Mg-sulfate. We registered 86 term and preterm neonates (43 in each group) using simple census method delivered through vagina to preeclampsia pregnant women treated with Mg-sulfate immediately before birth in Khoramabad Asali Hospital, Iran...
December 30, 2016: Cellular and Molecular Biology
J Zhang, Y Liu, S-Z Wei
The effect of benzo[a]pyrene (BaP) on Wistar rat lymphocyte activity, lymphocyle membrane integrity and erythrocytes hemolysis were examined using the MTT assay, the release of the lactate dehydrogenase (LD) and the hemoglobin release respectively in vitro. The results showed that lymphocyte activity had no remarkable response to BaP after a low dose of exposure. But the membrane change was found after higher dose of BaP exposure, and the significant release of LD was observed. The release of LD increased with exposure time prolonging and exposure dose increasing...
December 30, 2016: Cellular and Molecular Biology
S Yousef, R Mamdouh
Seroprevalence of Salmonella spp. was investigated in pigeon and its surrounding environment of Sharkia province, Egypt. Samples were randomly collected from fifty freshly dead squabs, forty freshly dead adults pigeons, sixty diseased adult pigeons and 100 apparently healthy adult pigeons. Bacterial isolates were tested for their susceptibility to 17 different antimicrobial discs, by using the disc diffusion method. The bacterial isolates were tested for Class I and β-lactamase encoding genes by using PCR...
December 30, 2016: Cellular and Molecular Biology
K Hadami, R Ameziane El Hassani, A Ameur, N Dakka, M Abbar, A Al Bouzidi, M Attaleb, M El Mzibri
Worldwide, Bladder cancer is the most frequent male malignancy. It is the third most common male malignancy in Morocco. The risk factors for developing bladder cancer are multiples including dietary conditions, environmental exposure and oxidative stress. GPX1 gene encoding for the human cellular antioxidant enzyme glutathione peroxidase1 is a key factor in the cell detoxification process. GPX1 Pro198Leu polymorphism is associated with a decrease of enzyme activity and may contribute to bladder cancer susceptibility...
December 30, 2016: Cellular and Molecular Biology
D Li, Z Fang, X Long, R Tang, S Di
Enhanced biological phosphorus removal (EBPR) has been widely used in wastewater treatment. In this study, a laboratory investigation of activated sludge in A/O-SBR reactor was conducted to probe the effects of the matrix types on EBPR polyphosphate, intracellular polysaccharide, polyhydroxyalkanoates (PHA) formation and transformation. There is a decrease in anaerobic condition and an increase in aerobic condition for the intracellular glycogen of sodium propionate matrix and sodium acetate matrix. While the intracellular glycogen of glucose matrix shows a decreasing tendency in both anaerobic and aerobic reaction process...
December 30, 2016: Cellular and Molecular Biology
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