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Cellular and Molecular Biology

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https://www.readbyqxmd.com/read/28478806/the-emerging-role-of-oxidative-stress-in-regulating-autophagy-applications-of-cancer-therapy
#1
W Zhang, X Wan, Z Liu, L Xiao, H Huang, X Liu
Emerging evidences show that autophagy, as a major cellular adaptive degradation mechanism, is involved in tumorigenesis, cell aging, inflammation and neurodegeneration. It has been reported that multiple stresses including nutrient deprivation, pathogen infection, oxidative stress, endoplasmic reticulum (ER) stress and metabolic stress can influence cellular autophagy, leading to distinct cell fate. Although numerous studies have been employed to elucidate the probable issues, the underlying mechanism of the initiation and maturation of autophagy remains unclear...
April 29, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28478805/clostridium-butyricum-partially-regulates-the-development-of-colitis-associated-cancer-through-mir-200c
#2
Y Xiao, X Dai, K Li, G Gui, J Liu, H Yang
Colitis-associated cancer (CAC), one form of colorectal cancer (CRC),is an increasing concern worldwide. Both diagnosis and current therapy are challenging and bottlenecked. The aim of this study is to investigate novel mechanisms by which the therapeutic C. butyricum regulates colitis-induced oncogenesis. Mouse models of CAC were established with 2,4,6-Trinitrobenzenesulfonic acid (TNBS)and azoxymethane (AOM), following by biochemical, clinical and histological analysis. The integrity of epitheliumwas examined by electron microscopy (EM)...
April 29, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28478804/connexin-43-enhances-oxaliplatin-cytotoxicity-in-colorectal-cancer-cell-lines
#3
S Q Wang, S W Zhang, C Z Zhang, Z Y Zhao, Y J Wang
Oxaliplatin, a platinum-based chemotherapeutic agent, is an important first-line drug in the treatment of colorectal cancers, but drug resistance causes treatment failure. It has been reported that gap junctional communication can enhance the cytotoxicity of platinum drugs.  The gap junction formed of connexin proteins provides a direct pathway for electrical and metabolic cell-cell interaction. The voltage-dependent gating of gap junction allows small hydrophilic molecules and ions to permeate to adjacent cells...
April 29, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28478803/peptide-11r-vivit-stimulates-osteoblastogenesis-through-regulating-the-expression-of-nuclear-factor-of-activated-t-cells-cytoplasmic-1
#4
M Li, X Wang, Z Bian, W Yao, Q He, F Tian, J Zhang, L Zhu
Osteoporosis is characterized by the imbalance of two relatively independent processes-osteoblastogenesis and osteoclastogenesis. Calcineurin (Cn)/nuclear factor of activated T cells (NFAT)(Cn/NFAT) signaling pathway is involved in these two processes in bone metabolism, but its potential as a target to treat osteoporosis needs to be defined. The aim of this study is to investigate the inhibition of polypeptide 11R-VIVIT onCn/NFAT signaling pathway. Rat calvaria (RC) cells were prepared from experimental model of osteoporosis in rat...
April 29, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28478802/electroacupuncture-ameliorates-spatial-learning-and-memory-impairment-via-attenuating-nox2-related-oxidative-stress-in-a-rat-model-of-alzheimer-s-disease-induced-by-a%C3%AE-1-42
#5
G Wu, L Li, H-M Li, Y Zeng, W-C Wu
Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by progressive deterioration of cognition and memory, in which oxidative stress has been played a crucial role in the pathology of AD. Electroacupuncture (EA) is a widely used therapy based on traditional acupuncture combined with modern electrotherapy in Asia. The present study aimed to determine the effects of EA treatment on spatial learning and memory impairment, and to elucidate the status of NOX2-related oxidative stress in a rat model of Alzheimer's disease induced by Beta-amyloid1-42 (Aβ1-42)...
April 29, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28478801/involvement-of-trpc1-in-nampt-induced-cardiomyocyte-hypertrophy-through-the-activation-of-er-stress
#6
J Li, W Wu, M Zhao, X Liu
Nicotinamide phosphoribosyltransferase (Nampt) is involved in the development of cardiac hypertrophy. Transient receptor potential canonical channel 1 (TRPC1) and endoplasmic reticulum stress (ER stress) are regarded as critical pathways in cardiac hypertrophy. Therefore, we hypothesizedthat TRPC1 might be associated with ER stress in Nampt-induced cardiac hypertrophy. CulturedH9c2cardiomyocyteswereexposed to Namptfor different timesand the expression of markers of cardiomyocyte hypertrophy and ER stress, as well as TRPC1 were detected...
April 29, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28478800/hif-1%C3%AE-mediates-visfatin-induced-ctgf-expression-in-vascular-endothelial-cells
#7
W Wu, J Li, M Zhao, X Liu
Visfatin is an adipokine that functions as a mediator of endothelial dysfunction and cardiovascular diseases. Connective tissue growth factor (CTGF) is a key factor in vascular remodeling and atherosclerosis. However, the association between visfatin and CTGF is unclear. Therefore the study was to test the hypothesis that visfatin could modulate the expression of CTGF in vascular endothelial cells. In our study, cultured endothelial cell line EA.Hy926 cells were treated with different concentrations of visfatin for different times...
April 29, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28478799/role-of-microrna-124-in-cardiomyocyte-hypertrophy-inducedby-angiotensin-ii
#8
Q Bao, L Chen, J Li, M Zhao, S Wu, W Wu, X Liu
Cardiac hypertrophy is a crucial predictor of heart failure and is regulated by microRNAs. MicroRNA-124 (miR-124) is regarded as a prognostic indicator for outcomes after cardiac arrest. However, whether miR-124 participates in cardiac hypertrophy remains unclear. Therefore, our study aimed to determine the role of miR-124 in angiotensin II(AngII)-induced myocardial hypertrophy and the possible mechanism. Primary cultured rat neonatal cardiomyocytes(NCMs) were transfected with miR-124 mimics or inhibitor, followed by AngII stimulation...
April 29, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28478798/sphingosine-1-phosphate-reduces-adhesion-of-malignant-mammary-tumor-cells-mda-mb-231-to-microvessel-walls-by-protecting-endothelial-surface-glycocalyx
#9
L Zhang, M Zeng, B M Fu
Sphingosine-1-phosphate (S1P) is a sphingolipid in plasma that plays a critical role in cardiovascular and immune systems. Endothelial surface glycocalyx (ESG) decorating the inner wall of blood vessels is a regulator of multiple vascular functions. To test the hypothesis that S1P can reduce tumor cell adhesion to microvessel walls by protecting the ESG, we quantified the ESG and MDA-MB-231 tumor cell adhesion in the presence and absence of 1μM S1P, and in the presence of the matrix metalloproteinase (MMP) inhibitor in post-capillary venules of rat mesentery...
April 29, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28478797/effect-of-matrix-rigidity-on-organ-specific-capture-of-tumor-cells-by-flow
#10
P Ma, X Shen, P Tan, L Yang, W Liu
Accumulating evidences have suggested that tumor metastasis exists prominent organ discrepancy. In this progression, the capture of intravascular tumor cells (TCs) to endothelium in distant tissues and organs plays a decisive role in the organ-specific metastasis formation. However, the mechanism of tumor cells preferentially arrest and adhere to endothelial cells (ECs) of target organ still remains elusive. By using the parallel plate flow chamber and the polyacrylamide gels with different matrix stiffness, we here explored the combined effects of matrix rigidity, shear stress, and chemokine SDF-1 on the capture of circulating tumor cells to ECs in the bloodstream...
April 29, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28478796/platelet-derived-mir-142-3p-induces-apoptosis-of-endothelial-cells-in-hypertension
#11
H Bao, Q-P Yao, K Huang, X-H Chen, Y Han, Z-L Jiang, L-Z Gao, Y-X Qi
The dysfunction of endothelial cells (ECs) plays crucial roles in vascular remodeling during hypertension. Researches suggested that ECs are regulated by the circulating platelets in vivo, which may participate in abnormal EC apoptosis in hypertension. However the molecular mechanism in this process is still unclear. Here we focused on the microRNAs (miRs) in platelets, and detected the potential role and delivery mechanism of platelet-derived miRs in ECs. Using microarray, the differentially expressed profile of miRs between platelets and ECs was detected...
April 29, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28478795/cell-biology-biophysics-and-mechanobiology-from-the-basics-to-clinics
#12
Y Zeng
Cell biology, biomechanics and biophysics are the key subjects that guide our understanding in diverse areas of tissue growth, development, remodeling and homeostasis. Novel discoveries such as molecular mechanism, and mechanobiological mechanism in cell biology, biomechanics and biophysics play essential roles in our understanding of the pathogenesis of various human diseases, as well as in designing the treatment of these diseases. In addition, studies in these areas will also facilitate early diagnostics of human diseases, such as cardiovascular diseases and cancer...
April 29, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28466822/the-effects-of-cdkn2a-rs3731249-rs11515-and-rs3088440-polymorphisms-on-cancer-risk
#13
Y Dong, X Wang, Y-W Yang, Y-J Liu
Many studies have been carried out to examine whether there is an association between CDKN2A polymorphisms and cancer risk, but the results from these studies were controversial. In the present study, we performed a meta-analysis to clarify whether there is an association of CDKN2A polymorphisms and cancer risk. Published reports were searched in PubMed and Google Scholar. ORs with 95% CIs were calculated in the dominant models. Twenty six case-control studies that met the inclusion criteria were included in the final meta-analysis...
March 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28466821/long-non-codingrna-lncrna-tug1-and-the-prognosis-of-cancer-a-meta-analysis
#14
X-H Yu, W Guo, J Zhang, C Ma, A-J Chu, B-L Wen, X Zhang, X-Y Yan, C-M Wu, D-M Wang, Y-L Qu
Some studies assessed the association between lncRNA taurine-upregulated gene 1 (TUG1) and the survival in cancer. However, the results were inconclusive.  Therefore, we performed a meta-analysis to determine this association. We used the following electronic databases to search for eligible literature: PubMed, Embase, Chinese National Knowledge Infrastructure (CNKI) and Wanfang. We used ORs and 95% CIs to measure the association between TUG1 and the survival of cancer. There was no significant association between TUG1 and OS of cancer (HR=1...
March 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28466820/association-between-bank1-polymorphisms-and-susceptibility-to-autoimmune-diseases-a-meta-analysis
#15
S-C Bae, Y H Lee
This study aimed to explore whether BANK1 polymorphisms are associated with susceptibility to autoimmune diseases. We conducted a meta-analysis on the associations between the BANK1 rs10516487, rs3733197, and rs17266594 polymorphisms and autoimmune diseases. Twenty-two articles with a total of 22,684 patients and 36,437 controls were included in the meta-analysis. Meta-analysis revealed a significant association between autoimmune diseases and the BANK1 rs10516487 T allele (OR = 1.161, 95% CI = 1.092-1.275, p = 1...
March 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28466819/familial-mediterranean-fever-observations-from-a-pilot-gene-expression-microarray-analysis-study
#16
R Mahfouz, K Kreidieh, R A Khalek, S Yazbek
Familial Mediterranean Fever (FMF) is an autosomal recessive autoinflammatory disease affecting people of Mediterranean ancestry. The disease is caused by mutations in the MEFV gene located on chromosome 16p13.3. The aim of this pilot study was to assess global gene expression and identify genes and pathways involved in FMF that could be downstream to MEFV mutations or could be novel involved. EDTA blood samples were collected from 14 patients showing FMF-like symptoms and age-matched to 7 controls showing healthy conditions...
March 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28466818/evaluation-of-relationship-between-aerobic-fitness-level-and-range-of-isocapnic-buffering-periods-during-incremental-exercise-test
#17
S Algul, O Ozcelik, B Yilmaz
The purpose of this study is to examine the relationship between the amount of O2 uptake (VO2) in the range of isocapnic buffering (ICB) periods and aerobic fitness levels of subjects with different exercise tolerance levels. A total of 50 young male subjects (20.8±0.4 years) performed an incremental exercise test using a cycle ergometer to determinetheir anaerobic threshold (AT), respiratory compensation point (RCP) and maximal exercise capacity (Wmax). The ICB period is defined as the region between AT and RCP...
March 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28466817/dynamic-observation-of-il-33-and-its-receptors-in-hiv-patients-who-received-haart
#18
B He, L Zheng, H Zhou, Y He, Z Chen, S Xiao, H Wang, Y Ling, Y Zheng
The purpose of this study was to observe the changes in serum IL-33 and its soluble receptors, serum sST2 level and ST2L expression in PBMCs of HIV-infected patients receiving highly-active antiretroviral therapy (HAART) for 12 monthes. Fifty-five chronic HIV-1-infected adults were recruited for this study before initiation of HAART. 30 age and gender matched healthy adults were recruited as control. Blood was obtained from each patient at baseline (0 month) and 12 months after initiation of highly active antiretroviral therapy(HAART), and each healthy person...
March 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28466816/antioxidant-effect-of-curcumin-against-exposure-to-malathion-in-cyprinus-carpio
#19
S Mişe Yonar, M E Yonar, M Ş Ural
The aim of this study was to determine protective effects of curcumin on oxidant/antioxidant parameters in Cyprinus carpio exposed to malathion. The fish were exposed to two sublethal concentrations of malathion (0.5 and 1 mg/L), and curcumin (100 mg per kg of fish weight) was simultaneously administered for 14 days. Malondialdehyde level and superoxide dismutase, catalase, glutathione peroxidase, and glutathione-S-transferase  activities were monitored in liver, kidney and gills, which were collected at the end of the experiment...
March 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28466815/the-study-of-cd14-hla-dr-low-myeloid-drived-suppressor-cell-mdsc-in-peripheral-blood-of-peripheral-t-cell-lymphoma-patients-and-its-biological-function
#20
J Du, X Sun, Y Song
Peripheral T-cell lymphoma is the generic term of a group of heterogeneous disease in non-Hodgkin's lymphoma. To investigate the quantity of CD14+HLA-DR-/low MDSC and T cell subsets in peripheral blood of peripheral T cell lymphoma (PTCL) patients, and explore the biological functions of CD14+HLA-DR-/low MDSC in peripheral T-cell lymphoma. Flow cytometry was used to determine CD14+HLA-DR-/low MDSC and T cell subsets in peripheral blood of 33 peripheral T-cell lymphoma patients and 23 healthy cases; CD3 +T cells, CD14+HLA-DR-/low MDSC cells and HLA-DR+ cells were selected with magnetic activated cell sorting; Biotin-labeled micro magnetic beads (CD2 / CD3 / CD28) were used to stimulate amplification of CD3 + T cells, which were co-cultured and analyzed by flow cytometry for the effect of different concentrations of CD14+HLA-DR-/low MDSC on the proliferative activity of autologous CD3+ T cells...
March 31, 2017: Cellular and Molecular Biology
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