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Journal of the European Academy of Dermatology and Venereology: JEADV

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https://www.readbyqxmd.com/read/28925576/is-there-an-increased-risk-of-cervical-neoplasia-in-atopic-dermatitis-patients-treated-with-oral-immunosuppressive-drugs
#1
F M Garritsen, R H M Verheijen, C G Gerestein, A D van Zuilen, J A F Oosterhaven, M van Dijk, C A F Bruijnzeel-Koomen, M L Schuttelaar, M S de Bruin-Weller
BACKGROUND: Oral immunosuppressive drugs are frequently prescribed in young women with atopic dermatitis (AD). Immunocompromised patients may have a higher risk of developing high risk HPV infections, CIN and cervical carcinoma. Most literature on patients using oral immunosuppressive drugs is available in organ transplant patients. Literature on the risk of developing cervical carcinoma in AD patients treated with oral immunosuppressive drugs is lacking. At this moment there is no clear guideline/consensus on this topic, but in daily practice, questions arise concerning whether this risk is increased and whether more intensive screening in women using immunosuppressive drugs should take place...
September 19, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28925560/apremilast-in-psoriasis-a-prospective-real-world-study
#2
I Vujic, R Herman, M Sanlorenzo, C Posch, B Monshi, K Rappersberger, L Richter
BACKGROUND: Apremilast is a novel oral phosphodiesterase-4 inhibitor approved for psoriasis treatment. Randomized trials have documented its efficacy and safety, but data on real-world patients are scarce. OBJECTIVES: We aim to characterize psoriasis patients treated with apremilast in a real-world setting and calculate drug survival as an important measure of efficacy and compliance. METHODS: All psoriasis patients that received apremilast between April 1(st) 2015 and January 19(th) 2017 were evaluated every 4 weeks and we documented: age, weight, height, smoking status, family history of psoriasis, joint involvement, previous treatments, psoriasis area severity index (PASI) scores, and the onset and duration of adverse events (AE)...
September 19, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28925002/verrucous-epidermal-nevus-a-misleading-diagnosis-for-28-years
#3
Jorge Ocampo-Garza, Nilton Gioia Di Chiacchio, Eckart Haneke, Nilton Di Chiacchio, Leandro Fonseca Noriega
Epidermal nevi (EN) are hamartomas of the skin that result from mosaic post-zygotic mutations. There are several variants of EN, the verrucous epidermal nevus (VEN) being the most common. EN can be further subdivided into epidermolytic and nonepidermolytic, important since in contrast with nonepidermolytic EN, epidermolytic EN occurs sporadically (not heritable), and it is not associated with extracutaneous abnormalities. This article is protected by copyright. All rights reserved.
September 19, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28924993/acquired-a-haemophilia-a-case-report
#4
E Cinotti, E Trovato, M Fimiani, P Rubegni
Acquired haemophilia A (AHA) due to autoantibodies against Factor VIII (FVIII) is a rare disease associated with severe bleeding. Since diffuse cutaneous hematomas and ecchymoses are the main clinical signs of this condition, dermatologists should be aware about this disease. Here, we present a case of AHA in a patient with systemic lupus erythematosus (SLE). This article is protected by copyright. All rights reserved.
September 19, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28924988/benefit-from-reslizumab-treatment-in-a-patient-with-chronic-spontaneous-urticaria-and-cold-urticaria
#5
Marcus Maurer, Sabine Altrichter, Martin Metz, Torsten Zuberbier, Martin K Church, Karl-Christian Bergmann
Chronic urticaria (CU) is a group of common and debilitating conditions containing both chronic spontaneous urticaria (CSU) and chronic inducible urticarias (CIndU) including cold urticaria (ColdU) [1]. While antihistamines and omalizumab are effective treatments for both CSU and ColdU [2], many patients show insufficient response to either or both of these treatments [3], and additional and better therapies are needed [4]. This article is protected by copyright. All rights reserved.
September 19, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28924985/not-a-simple-plantar-wart-a-case-of-tungiasis
#6
F Peccerillo, F Zambito Spadaro, G Fabrizi, C Feliciani, C Pagliarello, I Stanganelli
A 62-year-old Caucasian woman complained of a painful nodular lesion on her right heel that restricted her walking. She had noticed the onset of the itching after approximately 3 weeks of travel in Brazil. She was initially treated by her general practitioner with topical salicylic acid, suspecting a plantar wart. After a week of increased itching and unbearable pain, the patient was referred to our dermatological service. This article is protected by copyright. All rights reserved.
September 19, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28924975/trichoscopic-spectrum-of-folliculotropic-mycosis-fungoides
#7
Martyna Sławińska, Michał Sobjanek, Berenika Olszewska, Roman Nowicki, Małgorzata Sokołowska-Wojdyło
Folliculotropic mycosis fungoides (F-MF) is a variant of mycosis fungoides characterized by preferential infiltration of the follicular epithelium by atypical T lymphocytes, with or without follicular mucinosis or infiltration of the intervening epidermis. It is the most common subtype of mycosis fungoides (MF) in adults, with 4% frequency according to WHO classification. Follicular mucinosis refers to depositions of mucin within the follicular epithelium, which may be idiopathic or associated with different benign or malignant skin diseases, including MF...
September 19, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28921696/exome-sequencing-identifies-a-tcf4-mutation-in-a-chinese-pedigree-with-symmetrical-acral-keratoderma
#8
Pingjiao Chen, Silong Sun, Kang Zeng, Changxing Li, Ju Wen, Jingyao Liang, Xin Tian, Yiqi Jiang, Jing Zhang, Sanquan Zhang, Kai Han, Chunlei Han, Xibao Zhang
BACKGROUND: Symmetrical acral keratoderma (SAK) is a rare skin disorder and its pathogenesis and inheritability are unknown. OBJECTIVES: To investigate the inheritance and pathogenesis of SAK. METHODS: Four SAK cases occurred in a four-generation Chinese family. Exome sequencing identified SNPs with potential SAK related mutations, and a potentially responsible gene (Transcription factor 4, TCF4) was identified. TCF4 was then sequenced in all 11 family members and pedigree analysis was performed...
September 18, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28921662/atenolol-treatment-for%C3%A2-severe-infantile-hemangiomas-a-single-centre-prospective-study
#9
LETTER
A Alexopoulos, I Thanopoulou, M Dakoutrou, E Georgiadou, G P Chrousos, T Kakourou
Infantile hemangiomas (IHs) are common benign vascular tumors of infancy with an incidence of 4-5% (1) . The majority of IHs are self-limited, though in approximately 10% of patients, when their lesions compromise vital and sensory functions or cause disfigurement, medical treatment is warranted (2,3) . Τhe most exciting development in the treatment for IHs over the last decade has been the discovery of propranolol's effects during the proliferative phase of the hemangioma cycle (4) . This article is protected by copyright...
September 18, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28898541/biologics-combined-with-conventional-systemic-agents-or-phototherapy-for-the-treatment-of-psoriasis-real-life-data-from-psonet-registries
#10
C I Busard, A D Cohen, P Wolf, S Gkalpakiotis, S Cazzaniga, R S Stern, B A Hutten, I Feldhamer, F Quehenberger, R Lichem, M Kojanova, E Adenubiova, A Addis, L Naldi, P I Spuls
BACKGROUND: Biologics have greatly improved psoriasis management. However, primary and secondary non-response to treatment requires innovative strategies to optimize outcomes. OBJECTIVE: To describe the use of combined treatment of biologics with conventional systemic agents or phototherapy in daily clinical practice. METHODS: We collected data on frequency of use, demographics, treatment characteristics and drug survival of biologics combined with conventional systemic agents or phototherapy in five PSONET registries...
September 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28898474/quality-of-life-measurement-in-acne-position-paper-of-the-european-academy-of-dermatology-and-venereology-eadv-task-forces-on-quality-of-life-and-patient-oriented-outcomes-qol-and-po-and-acne-rosacea-and-hidradenitis-suppurativa-arhs
#11
REVIEW
P V Chernyshov, C C Zouboulis, L Tomas-Aragones, G B Jemec, L Manolache, T Tzellos, F Sampogna, A W M Evers, C Dessinioti, S E Marron, V Bettoli, O D van Cranenburgh, A Svensson, A I Liakou, F Poot, J C Szepietowski, Salek, A Y Finlay
Acne causes profound negative psychological and social effects on the quality of life (QoL) of patients. The European Dermatology Forum S3-Guideline for the Treatment of Acne recommended adopting a QoL measure as an integral part of acne management. Because of constantly growing interest in health-related QoL assessment in acne and because of the high impact of acne on patients' lives, the European Academy of Dermatology and Venereology Task Force on QoL and Patient Oriented Outcomes and the Task Force on Acne, Rosacea and Hidradenitis Suppurativa have documented the QoL instruments that have been used in acne patients, with information on validation, purposes of their usage, description of common limitations and mistakes in their usage and overall recommendations...
September 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28898467/mohs-micrographic-surgery-in-the-elderly-comparison-of-tumours-surgery-and-first-year-follow-up-in-patients-younger-and-older-than-80-years-old-in-regesmohs
#12
C Camarero-Mulas, Y Delgado Jiménez, O Sanmartín-Jiménez, J R Garcés, M A Rodríguez-Prieto, T Alonso-Alonso, R Miñano Medrano, J L López-Estebaranz, E de Eusebio Murillo, P Redondo, C Ciudad-Blanco, A Toll-Abelló, J L Artola Igarza, I Allende Markixana, R Suarez Fernández, A Alfaro Rubio, M L Alonso Pacheco, H Vázquez-Veiga, P de la Cueva Dobao, V Ruiz-Salas, E Vilarrasa Rull, L Barchino, V Morales-Gordillo, I Ocerin-Guerra, R Navarro Tejedor, L Hueso, M Mayor Arenal, M J Seoane-Pose, N Cano-Martinez, I Garcia-Doval, M A Descalzo
BACKGROUND: The elderly population is increasing and more patients in this group undergo Mohs micrographic surgery. The few publications investigating MMS in elderly people conclude that it is a safe procedure; however, these are single centre studies without a comparison group. OBJECTIVE: To compare the characteristics of patients, tumours, MMS, and one-year follow-up in patients younger than 80 years, with patients older than 80 years at the time of surgery. METHODS: Data was analysed from REGESMOHS, a prospective cohort study of patients treated with MMS...
September 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28898461/risks-of-different-skin-tumor-combinations-after-a-first-melanoma-squamous-cell-carcinoma-and-basal-cell-carcinoma-in-dutch-population-based-cohorts-1989-2009
#13
R J T van der Leest, L M Hollestein, L Liu, T Nijsten, E de Vries
BACKGROUND: Skin cancer patients are primarily at increased risk of developing subsequent skin cancers of the same type. Shared risk factors might also increase the occurrence of a different type of subsequent skin cancer. OBJECTIVE: To investigate risks of different skin tumor combinations after a first melanoma, squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). METHODS: All melanoma and SCC patients included in the national Netherlands Cancer Registry (NCR) and all BCC patients included in the regional Eindhoven Cancer Registry (ECR) between 1989 and 2009 were followed until diagnosis of a subsequent different skin cancer (melanoma, SCC or BCC), date of death or end of study...
September 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28898460/burden-of-chronic-urticaria-relative-to-psoriasis-in-five-european-countries
#14
M M Balp, S Khalil, H Tian, S Gabriel, J Vietri, T Zuberbier
BACKGROUND: Quantification of burden of chronic spontaneous urticaria (CSU) versus psoriasis (PsO) is limited. OBJECTIVE: To evaluate the burden associated with CSU versus PsO of all severities (overall PsO), mild and moderate/severe PsO. METHODS: his retrospective cross-sectional analysis compared data from adult patients with chronic urticaria (CU), used as a proxy for CSU, and PsO from the National Health and Wellness Survey in France, Germany, Italy, Spain, and the United Kingdom...
September 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28895209/focal-hyperkeratosis-overlying-the-palmar-faces-of-interphalangeal-and-metacarpophalangeal-joints-revealing-a-juvenile-dermatomyositis
#15
C Abasq-Thomas, V Devauchelle, S Fraitag, N Jay, G Gourier, A Le Duc Pennec, E Brenaut, L Misery
Dermatomyositis (DM) is an idiopathic inflammatory myopathy characterized by an inflammatory infiltrate primarily affecting the skeletal muscle and skin [1]. It is the commonest of the idiopathic inflammatory myopathies of childhood, comprising 85% of cases. It has an annual incidence estimated to range between 1.9 and 4.1 per million children [2, 3]. This article is protected by copyright. All rights reserved.
September 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28895202/european-s3-guideline-on-the-systemic-treatment-of-psoriasis-vulgaris-update-apremilast-and-secukinumab-edf-in-cooperation-with-eadv-and-ipc
#16
LETTER
A Nast, P I Spuls, G van der Kraaij, P Gisondi, C Paul, A D Ormerod, P Saiag, C H Smith, E Dauden, E M de Jong, E Feist, R Jobling, M Maccarone, U Mrowietz, K A Papp, K Reich, S Rosumeck, T Talme, H B Thio, P van de Kerkhof, R N Werner, C Dressler
No abstract text is available yet for this article.
September 11, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28881462/impact-of-ixekizumab-on-facial-psoriasis-and-related-quality-of-life-measures-in-moderate-to-severe-psoriasis-patients-12-week-results-from-2-phase-iii-trials
#17
C Paul, L Guenther, H Torii, H Sofen, R Burge, C Y Lin, A Potts Bleakman, L Mallbris, Y Poulin
BACKGROUND: Facial psoriasis was reported in 17-68% of patients with psoriasis and shown to have a negative impact on patients' personal and health-related quality of life (HRQoL). OBJECTIVES: Explore the association of facial psoriasis with patients' HRQoL and assess the relationship between ixekizumab (IXE) and improvement in facial psoriasis and changes in HRQoL. METHODS: This work reports the combined results of 2 phase III multicenter, randomized, double-blind, placebo-controlled, active-comparator trials in patients with moderate-to-severe psoriasis...
September 7, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28869804/erosive-pustular-dermatosis-of-the-scalp-and-kindler-syndrome-a-new-association
#18
L Atzori, M Lai, A Lappi, M A Brundu, F Rongioletti
Erosive pustular dermatosis of the scalp (EPDS) is a rare inflammatory disease that predominantly affects elderly people, with a chronic course and long-term management.(1) Sterile pustules, superficial erosions and crusted lesions on atrophic skin, resulting in cicatricial alopecia, characterize the typical clinical presentation. (1-3) Triggering factors include several drugs, actinic damage, local trauma, surgery, and physical or chemical procedures for actinic keratosis.(4-6) To the best of our knowledge, no previous association with Kindler syndrome was found in the literature...
September 4, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28865162/three-new-cases-of-bullous-pemphigoid-during-anti-pd-1-antibody-therapy
#19
S Le Naour, L Peuvrel, M Saint-Jean, B Dreno, G Quereux
Anti-programmed death 1 (PD-1) antibodies are revolutionizing the treatment of many cancers, including melanoma (1) . Cutaneous adverse events (AE) of anti-PD-1 antibodies are common (20%) and mainly non-specific. Bullous pemphigoids (BP) are very rare immune-related AEs induced by anti-PD-1 antibodies, with only 12 cases previously published. We report here three new cases of BP during anti PD-1 therapy with nivolumab. This article is protected by copyright. All rights reserved.
September 2, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28862807/clinical-pathological-and-dermoscopic-characteristics-of-cutaneous-lesions-in-leopard-syndrome
#20
J Banuls, P J Álvarez-Chinchilla, A Lucas, I Poveda, B Encabo-Durán, M Niveiro, E Nagore, P Zaballos
LEOPARD syndrome (LS) is a rare autosomal disorder associated with multiple congenital anomalies. This term is an acronym for Lentigines (LT), Electrocardiographic conduction defects, Ocular hypertelorism, Pulmonary valve stenosis, Abnormalities of the genitalia, Retardation of growth, and Deafness (1-3) . Mutations in PTPN11 gene cause this syndrome in around 90% of cases, and less frequently other mutations produce this entity(3-4) . This article is protected by copyright. All rights reserved.
September 1, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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