journal
MENU ▼
Read by QxMD icon Read
search

Journal of the European Academy of Dermatology and Venereology: JEADV

journal
https://www.readbyqxmd.com/read/30005134/a-practical-application-of-onychomycosis-cure-combining-patient-physician-and-regulatory-body-perspectives
#1
REVIEW
Aditya K Gupta, Sarah G Versteeg, Neil H Shear
Due to the high relapse rates and the rise of predisposing factors, the need for curing onychomycosis is paramount. To effectively address onychomycosis, the definition of cure used in a clinical setting should be agreed upon and applied homogenously across therapies (e.g., oral, topical and laser treatments). In order to determine what is or what should be used to define cure in a clinical setting, a literature search was conducted to identify methods used to evaluate treatment success. The limitations, strengths, prevalence and utility of each outcome measure were investigated...
July 13, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30004597/the-clinical-effects-of-l-arginine-and-asymmetric-dimethylarginine-implications-for-treatment-in-secondary-raynaud-s-phenomenon
#2
REVIEW
P Curtiss, Z Schwager, K Lo Sicco, A G Franks
Secondary Raynaud's phenomenon (RP) is often the sentinel clinical finding in systemic sclerosis and may precede systemic disease by several years. Altered nitric oxide metabolism plays a critical role in both fibrosis and severe secondary RP phenotypes in these patients. Increased flux through inducible nitric oxide synthase (iNOS) drives cutaneous fibrosis. Failure of flux through endothelial nitric oxide synthase (eNOS) contributes to increased vasoconstriction and decreased vasorelaxation. The underproduction of nitric oxide by eNOS is in part due to increased levels of asymmetric dimethylarginine (ADMA), an endogenous competitive inhibitor of nitric oxide synthase...
July 13, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29998520/aligned-on-adherence-subanalysis-of-adherence-in-immune-mediated-inflammatory-diseases-in-the-dach-region-of-the-global-align-study
#3
Antonios G A Kolios, Axel J Hueber, Pierre Michetti, Ulrich Mrowietz, Monika Mustak-Blagusz, Paul-Gunther Sator, Max Reinshagen, Dagmar Wilsmann-Theis, Susana Gomis-Kleindienst, Ulrike Luckey, Alexander Rössler, Ingolf Schiefke
BACKGROUND: Non-adherence to medication is a challenging problem in daily clinical practice. OBJECTIVE: To assess reasons for non-adherence in patients with chronic immune-mediated inflammatory diseases (IMIDs) in a direct comparison including evaluation of treatment necessity and concerns. METHODS: ALIGN was a non-interventional, multi-country, multi-center, self-administered, cross-sectional, epidemiologic survey study. Here we investigate the German, Austrian, and Swiss (DACH) cohort...
July 12, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29992639/acute-generalized-exanthematous-pustulosis-a-case-series-of-13-patients-in-brazil
#4
D A M Costa, C A Seque, M M S S Enokihara, A M Porro
Acute generalized exanthematous pustulosis (AGEP) is an adverse drug reaction characterized by the sudden appearance of hundreds of sterile, non-follicular pustules, on an erythematous or edematous skin background, mainly in flexural areas, affecting equally men and women at any age. It was described in 19681 but classified as a disease distinctive from pustular psoriasis in 1980.Mucosal involvement is rare (20%), usually restricted to oral mucosa3 . Facial edema, lower limb purpura, atypical target-lesions (resembling Stevens-Johnson's syndrome) and blisters have been described, but are not common...
July 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29992638/factors-influencing-sessions-and-speakers-evaluation-an-analysis-of-seven-consecutive-eadv-congress-editions
#5
S Cazzaniga, L Scerri, J P Gabbud, P Arenberger, L Borradori, L Naldi
BACKGROUND: The variables affecting participants' satisfaction with a scientific conference in dermatology have not been systematically assessed. The European Academy of Dermatology and Venereology (EADV) has collected a huge number of questionnaires related to sessions' and speakers' evaluation over the years. The critical analysis of satisfaction's score is important and helpful for continuous improvement of the scientific programming. OBJECTIVE: To identify factors that positively or negatively affect sessions' and speakers' scoring in the largest European congress of dermatology...
July 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29992631/position-statement-for-the-management-of-comorbidities-in-psoriasis
#6
E Dauden, A J Blasco, C Bonanad, R Botella, J M Carrascosa, E González-Parra, E Jodar, B Joven, P Lázaro, A Olveira, J Quintero, R Rivera
BACKGROUND: The association between psoriasis and some diseases has become relevant in recent years. Providing appropriate management of psoriasis from an early stage requires prompt diagnosis and treatment of concomitant diseases and to prevent any potential comorbidity. This approach should consider the adverse events of the drugs used to treat psoriasis potentially related to the onset of comorbidities. OBJECTIVE: To provide the dermatologist with an accurate and friendly tool for systematising the diagnosis of psoriasis-associated comorbidities, which generally escapes the scope of the dermatology setting, and to facilitate decision-making about the referral and treatment of patients with comorbidities...
July 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29989662/head-to-head-trials-of-systemic-psoriasis-therapies-a-systematic-review-of-study-design-and-maximum-acceptable-treatment-differences
#7
REVIEW
M T Wan, J Alvarez, D B Shin, E D Dommasch, J J Wu, J M Gelfand
There is increasing use of head-to-head clinical trials in dermatology when establishing the efficacy of a new treatment. Active comparator trials (ACTs) can be classified into three distinct study trial designs: non-inferiority, equivalence, and superiority. A better understanding of the statistical parameters, such as acceptable treatment differences (also known as the margin or delta), is necessary to properly design and interpret findings of active comparator trials (ACTs) in the field of dermatology. Therefore, the objective of this study is to summarize the maximum acceptable treatment differences in clinical trials that examine the efficacy of an oral or biologic psoriasis therapy with an active comparator...
July 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29972879/diagnosis-of-anti-laminin-%C3%AE-1-pemphigoid-by-immunoblot-analysis
#8
Farzan Solimani, Robert Pollmann, Norito Ishii, Rüdiger Eming, Takashi Hashimoto, Thomas Schmidt, Michael Hertl
BACKGROUND: Anti-laminin-γ1 (lam-γ1) pemphigoid, a recently described immunobullous disorder sharing immune serological features of bullous pemphigoid and epidermolysis bullosa acquisita (EBA), is characterized by the detection of serum IgG autoantibodies against the lam-γ1 chain, a 200 kDa heterotrimeric component of the dermal-epidermal junction (DEJ). OBJECTIVE: The aim of the study was to develop an easy to perform and reliable assay for the serological detection of anti-lam-γ1 IgG autoantibodies...
July 4, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29972872/a-unique-presentation-of-petrified-ears-with-pain-due-to-fracture
#9
L Thomas, K Naidoo, P Woolfall, A J Carmichael
A 52-year-old man was referred with a presumptive diagnosis of chondrodermatitis nodularis helicis. He gave a 12-month history of pain affecting the helix of his right ear. Pain was exacerbated by washing and in bed at night. This article is protected by copyright. All rights reserved.
July 4, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29972866/physicochemical-characterization-of-inorganic-deposits-associated-with-granulomas-in-cutaneous-sarcoidosis
#10
H Colboc, P Moguelet, D Bazin, C Bachmeyer, V Frochot, R Weil, E Letavernier, C Jouanneau, M Daudon, J F Bernaudin
BACKGROUND: Sarcoidosis, characterized by epithelioid granulomas, is considered to be caused by a complex interplay between genetics and environmental agents. It has been hypothesized that exogenous inorganic particles as crystalline silica could be a causal or adjuvant agent in sarcoidosis onset. OBJECTIVES: To investigate the location, frequency and physicochemical characteristics of foreign materials and mineral tissue deposits in the granulomatous area of cutaneous sarcoidosis...
July 4, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29972712/a-randomized-double-blind-controlled-study-of-the-efficacy-and-safety-of-topical-solution-of-0-25-finasteride-admixed-with-3-minoxidil-versus-3-minoxidil-solution-in-the-treatment-of-male-androgenetic-alopecia
#11
P Suchonwanit, P Srisuwanwattana, N Chalermroj, S Khunkhet
BACKGROUND: The synergism of combined use between oral finasteride and topical minoxidil has been established in treating androgenetic alopecia among men. However, the concern regarding adverse effects of finasteride use has been rising. OBJECTIVE: To compare the efficacy and safety of topical solution of 0.25% finasteride admixed with 3% minoxidil versus 3% minoxidil solution in men with androgenetic alopecia. METHODS: Forty men aged 18 to 60 years with androgenetic alopecia were randomized to 24 weeks of treatment with a finasteride/minoxidil or minoxidil solution twice daily...
July 4, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29972710/identifying-key-components-for-a-psychological-intervention-for-people-with-vitiligo-a-quantitative-and-qualitative-study-in-the-united-kingdom-using-web-based-questionnaires-of-people-with-vitiligo-and-healthcare-professionals
#12
A Ahmed, L Steed, E Burden-Teh, R Shah, S Sanyal, S Tour, S Dowey, M Whitton, J M Batchelor, A P Bewley
BACKGROUND: Psychological interventions are recommended as part of routine management of vitiligo. However the development and effectiveness of such interventions has been rarely addressed. This study aims to identify key components for a psychological intervention for people with vitiligo. This is the first time perspectives of people with vitiligo and healthcare professionals (HCPs) have been directly explored to inform intervention content and delivery. OBJECTIVES: To identify: 1...
July 4, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29961950/rosacea-like-demodicosis-and-papulopustular-rosacea-may-be-two-phenotypes-of-the-same-disease-and-pityriasis-folliculorum-may-be-their-precursor-response-to-the-comment-of-tatu
#13
F Forton, V De Maertelaer
We thank Tatu et al for their comment1 on our recent article2 in which they agree with the idea that rosacea-like demodicosis (RLD) and papulopustular rosacea (PPR) may be two phenotypes of the same disease. Tatu et al raise the question of the potential role of some of the numerous species of bacteria3 inadvertently ingested by Demodex that could potentially influence its behaviour.1 We did not explore this interesting hypothesis in our study but agree that this and other types of interactions, such as those of Staphylococcus epidermidis,4 are important areas for future study...
July 1, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29959803/real-life-efficacy-and-safety-of-secukinumab-results-from-a-tertiary-hospital-in-greece
#14
Aikaterini Tsentemeidou, Elena Sotiriou, Efstratios Vakirlis, Nikolaos Sideris, Ilias Papadimitriou, Elisabeth Lazaridou, Demetrios Ioannides
Secukinumab is a recombinant monoclonal antibody that prevents interleukin 17A (IL-17A) from binding to its receptor, thus limiting inflammatory processes ultimately leading to excessive keratinocyte proliferation.1,2 According to phase-III clinical trials, it significantly reduces disease severity within a short period of time (PASI75>80% at week 12).3 Three real-life studies (47, 69 & 83 patients each) showed that 72.30%, 52.90% & 80.00% of treated subjects respectively achieved PASI75 at week 12...
June 29, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29959796/reliability-of-the-hidradenitis-suppurativa-clinical-response-hiscr-in-the-assessment-of-patients-with-hidradenitis-suppurativa
#15
A B Kimball, A Ganguli, A Fleischer
BACKGROUND: Hidradenitis suppurativa clinical response (HiSCR) is a validated clinical end point for measuring response to treatment in patients with hidradenitis suppurativa (HS). Previous studies have reported on the validity, responsiveness, and meaningfulness of the HiSCR. OBJECTIVE: To evaluate the HiSCR for inter- and intra-rater reliability characteristics. METHODS: A stand-alone, 2-site, prospective, non-interventional observational study consisted of 22 patients, with self-reported severity between mild, moderate, and severe HS...
June 29, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29959794/titanium-dioxide-nanoparticles-and-frontal-fibrosing-alopecia-cause-or-consequence
#16
Olivier Aerts, Annick Bracke, An Goossens, Veronique Meuleman, Julien Lambert
We read with interest the publication by Brunet-Possenti F et al. who report on the presence of titanium dioxide nanoparticles (TiO2 NP) along the hair shafts of a patient suffering from frontal fibrosing alopecia (FFA)1 . Given the widespread use of TiO2 NP in leave-on cosmetics, and particularly in sunscreens, and the recent publications reporting a 'possible' association between the use of sunscreens and the development of FFA2,3 , the authors suggest that a T-cell mediated allergic response to TiO2 NP, as occurs to metals involved in some cases of oral lichenoid lesions, might also be important in the pathophysiology of FFA...
June 29, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29959789/dermatology-more-than-an-outpatient-specialty
#17
Suchismita Paul, Anna J Nichols, Robert S Kirsner
Dermatologists care for a minority of patients hospitalized for skin disease. Few programs still train residents to provide care as the admitting physician for patients with cutaneous manifestations of systemic diseases or primary skin conditions. Despite this, dermatologic conditions affect a large proportion of hospital inpatients, both as the primary reason for admission or as a secondary diagnosis. This article is protected by copyright. All rights reserved.
June 29, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29959784/rosacea-like-demodicosis-but-not-primary-demodicosis-and-papulo-pustular-rosacea-may-be-two-phenotypes-of-the-same-disease-a-microbioma-therapeutic-and-diagnostic-tools-perspective
#18
Alin Laurentiu Tatu, Victor Gabriel Clatici, Lawrence Chukwudi Nwabudike
The scope of their research appears to be limited to the effects of Demodex spp in rosacea and thus does not consider possible confounding factors such as the effects of Bacillus oleronius, which has been isolated from Demodex folliculorum and been identified as a trigger of inflammation in rosacea(2). Other endosymbionts described as related to Demodex are:I.Bacillus simplex, which was isolated from Demodex folliculorum in a patient with primary demodicosis(3) II. Bacillus pumilus positive culture and mass spectrometry were found in a patient with rosacea and D...
June 29, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29956847/anti-tnf%C3%AE-therapy-modulates-mtorc1signalling-in-hidradenitis-suppurativa
#19
A Balato, G Caiazzo, M C Annunziata, C Marasca, E Scala, S Cacciapuoti, G Fabbrocini
Hidradenitis Suppurativa (HS) is a chronic, inflammatory, recurrent and debilitating skin disease of the hair follicle, which usually occurs after puberty with painful, deep-seated, inflammatory lesions in the apocrine gland-bearing areas of the body, most commonly in axillary, inguinal and anogenital regions This article is protected by copyright. All rights reserved.
June 29, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29953691/dermoscopy-in-disseminated-sporotrichosis
#20
G Dabas, H Kaur, K Vinay, M S Kumaran, M R Shivaprakash, U N Saikia, S Dogra
We read with interest the article by Slawinska et al1 on dermoscopic features of disseminated cryptococcosis. We would like to highlight the dermatoscopic features of disseminated sporotrichosis and discuss the similarities in the dermatoscopic features of various deep mycosis and cutaneous leishmaniasis. A 41-year-old male, resident of the Kashmir valley, presented for the evaluation of multiple ulcerated skin lesions since past 3 years. This article is protected by copyright. All rights reserved.
June 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
journal
journal
31187
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"