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Journal of the European Academy of Dermatology and Venereology: JEADV

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https://www.readbyqxmd.com/read/29776016/psoriasis-area-and-severity-index-pasi-response-in-moderate-severe-psoriatic-patients-switched-to-adalimumab-results-from-the-oppsa-study
#1
M Talamonti, M Galluzzo, N Bernardini, G Caldarola, S Persechino, F Cantoresi, C G Egan, C Potenza, K Peris, L Bianchi
BACKGROUND: Few studies have compared the efficacy of switching to adalimumab in the real-life setting in plaque psoriasis patients. OBJECTIVE: To evaluate the effect of adalimumab in psoriasis patients previously treated with other biologics. METHODS: In this multicentre study, psoriasis patients (N=262) treated with an anti-TNF alpha agent, ustekinumab or naïve to biologics then switched to adalimumab were included. Disease severity was assessed by the Psoriasis Area and Severity Index (PASI) at baseline and after 3, 6, 12, 24 and 36 months...
May 18, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29775506/dyschromatosis-symmetrica-hereditaria-with-chilblains-due-to-a-novel-two-amino-acid-deletion-in-the-double-stranded-rna-binding-domain-of-adar1
#2
M Kono, M Suganuma, T Shimada, Y Ishikura, S Watanabe, T Takeichi, Y Muro, M Akiyama
Dyschromatosis symmetrica hereditaria (DSH) is an autosomal dominant skin disease caused by a heterozygous mutation of ADAR1.1 DSH is characterized by a mixture of hyper- and hypo-pigmented small macules in the extremities. Among the mutations, the pathogenicity of in-frame deletion in regions other than the deaminase domain has not been clarified in DSH.2 This article is protected by copyright. All rights reserved.
May 18, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29775498/the-jarisch-herxheimer-reaction-in-syphilis-could-molecular-typing-help-to-understand-it-better
#3
M Arando, C Fernandez, M Mota-Foix, A Alvarez, P Armegol, M J Barberá, J Esperalba, M Vall-Mayans
OBJECTIVES: The Jarisch-Herxheimer reaction (JHR) is a febrile inflammatory reaction that may occur in patients after treatment of syphilis. The overall rate is estimated to be 10-25% with broad variations over time. It appears to be related to factors like stage of the disease or reagin titres. In this study we aimed to describe the incidence of and risk factors including strain typing for JHR among patients with syphilis. METHODS: From January through October 2015, 224 consecutive patients (82 of them with HIV) who were diagnosed with early syphilis were enrolled in this prospective observational study in a referral STI clinic in Barcelona...
May 18, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29775497/inflammatory-cytokines-and-peripheral-mediators-in-the-pathophysiology-of-pruritus-in-cutaneous-t-cell-lymphoma
#4
REVIEW
Daniel J Lewis, Simo Huang, Madeleine Duvic
Cutaneous T-cell lymphoma (CTCL) includes a diverse group of neoplasms, including mycosis fungoides and Sézary syndrome. One of the earliest and most common symptoms of CTCL is pruritus, which affects up to 88% of patients. The severity of pruritus can range from mild to very debilitating, producing tremendous discomfort and a significant decrease in quality of life. Patients with advanced disease, in particular, may experience a more chronic, intractable pruritus. However, the underlying mechanism of pruritus in CTCL remains unknown...
May 18, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29763522/genetic-polymorphism-of-thymic-stromal-lymphopoietin-in-korean-patients-with-atopic-dermatitis-and-allergic-march
#5
E J Ko, W I Heo, K Y Park, M-K Lee, S J Seo
Thymic stromal lymphopoietin(TSLP) is recognized as key cytokine in T helper type 2 (Th 2) cell differentiation and contributes to the pathogenesis of atopic disease. The TSLP gene on chromosome 5q22.1 and atopic cytokine gene on 5q31 are adjacent to each other. Based on their genetic location, it is suggested that the TSLP gene is involved in the progression or activity of atopic disease. Genetic association studies involving TSLP single nucleotide polymorphisms (SNPs) and allergic rhinitis or asthma in different racial group have yielded disparate and inconsistent results...
May 15, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29763518/tattoo-associated-uveitis-with-or-without-systemic-sarcoidosis-a-comparative-review-of-the-literature
#6
REVIEW
Nicolas Kluger
Sarcoidosis is a systemic disease of unknown aetiology characterized by the presence of non-caseating epithelioid cell granulomas in multiple organs, mainly the lungs and the lymphatic system. It is also one of the leading causes of inflammatory eye diseases. For the past 70 years, sarcoidal granulomas on tattoos and permanent make-up have been documented. They can be the first and sometimes unique cutaneous manifestation of systemic sarcoidosis. A few cases of sarcoidosis with uveitis and granulomatous reactions within tattoos have been described...
May 15, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29763514/measurement-of-health-care-quality-in-atopic-dermatitis-development-and-application-of-a-set-of-quality-indicators
#7
S Steinke, F C Beikert, A Langenbruch, R Fölster-Holst, J Ring, J Schmitt, T Werfel, S Hintzen, N Franzke, M Augustin
BACKGROUND: Quality indicators are essential tools for the assessment of health care, in particular for guideline-based procedures. OBJECTIVE: 1) Development of a set of indicators for the evaluation of process and outcomes quality in atopic dermatitis (AD) care. 2) Application of the indicators to a cross-sectional study and creation of a global process quality index. METHODS: An expert committee consisting of 10 members of the German guideline group on atopic dermatitis condensed potential quality indicators to a final set of 5 outcomes quality and 12 process quality indicators using a Delphi panel...
May 15, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29763511/a-review-of-non-invasive-imaging-in-extramammary-paget-s-disease
#8
REVIEW
Claire-Audrey Y Bayan, Trisha Khanna, Veronica Rotemberg, Faramarz H Samie, Nathalie C Zeitouni
Extramammary Paget's Disease (EMPD) is a rare intraepithelial adenocarcinoma that classically manifests with pruritic, erythematous, scaling plaques. The clinical picture frequently mimics inflammatory or infectious conditions, and is thus commonly misdiagnosed. The assessment of tumor margins is equally challenging as tumors have a propensity to spread beyond clinically visible boundaries. Appropriate non-invasive diagnostic tools can assist in the early detection, diagnosis, and management of EMPD. This paper will review the literature on non-invasive imaging modalities used in EMPD...
May 15, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29761904/prevalence-and-comorbidities-associated-with-hidradenitis-suppurativa-a-nationwide-population-based-study
#9
Ji Hae Lee, Hyuck Sun Kwon, Han Mi Jung, Gyong Moon Kim, Jung Min Bae
BACKGROUND: The prevalence of hidradenitis suppurativa (HS) in Asia is unknown. The associations between HS and other autoimmune disorders have rarely been reported. OBJECTIVE: We sought to determine the prevalence of and diseases associated with HS using the National Health Insurance (NHI) database. METHODS: We examined Korean NHI claim database data from 2007 to 2016. We enrolled all patients with HS and age- and sex-matched control subjects without HS...
May 15, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29761895/blurry-halos-after-tattooing-tattoo-blow-out-a-review-of-16-cases
#10
Nicolas Kluger
"Tattoo blow-out" (TBO) refers to the diffusion of tattoo inks deep in the hypodermis [1]. TBO presents as an asymptomatic, permanent, blurry halo of colour around the tattoo. It is rapidly visible after tattooing, but mistaken initially as a hematoma. It is only weeks after when the tattoo is healed that the customer starts to be concerned. This article is protected by copyright. All rights reserved.
May 15, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29761855/presence-of-scf-cxcl12-double-positive-large-blast-like-cells-at-the-site-of-cutaneous-extramedullary-hematopoiesis
#11
Toshiaki Kogame, Masahiro Hirata, Tatsuki R Kataoka, Judith A Seidel, Chiyuki Ueshima, Miho Matsui, Takashi Nomura, Kenji Kabashima
Extramedullary hematopoiesis (EMH) is observed in the fetal liver and the spleen under physiological conditions, but can rarely occur as pathologic condition after birth. EMH is observed in various anatomical sites in patients with hypoxia-inducing conditions, such as idiopathic myelofibrosis. The nature of the microenvironment for the maintenance of hematopoietic stem cells (HSCs) in EMH is unclear. Recent studies showed that mesenchymal stem/stromal cell (MSC)-derived cells, that can differentiate into various types of cells, play critical roles in the formation of hematopoietic niches...
May 15, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29747243/biosimilars
#12
J Barker
Biologics have had an enormous impact on the practice of medicine. In cancer, checkpoint inhibitors have dramatically improved survival, including in melanoma. In chronic inflammatory diseases their impact has been similarly impressive. To date in dermatology this has mainly been felt in the management of severe psoriasis. This article is protected by copyright. All rights reserved.
May 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29730899/smartphone-and-video-games-overuse-effects-on-hand-joints-time-for-screening-interventions
#13
Matteo Megna, Pietro Gisonni, Nicola Balato
We read with great interest the letter by Kluger and we completely agree that apart from smartphone addiction also other technologies overuse such as video games joysticks and controllers may have an effect on hand joints. Particularly, we have previously demonstrated that in psoriasis patients smartphone over-use is linked with higher signs of inflammation of muscoloskelatal structures of hands joints potentially being a factor which facilitate or speed up the possible development of psoriatic arthritis (PsA)...
May 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29730897/the-effect-of-autoimmune-blistering-diseases-on-work-productivity
#14
E Q Wang, M Radjenovic, M A Castrillón, G Feng, D F Murrell
BACKGROUND: Autoimmune blistering diseases (AIBD) is known to negatively impact upon quality of life (QoL), however there is a paucity of research on the effect of AIBD on work productivity. AIBD can be quite disfiguring in terms of a patient's appearance due to its blistering nature. OBJECTIVE: To determine the impact of AIBD on work productivity and to determine whether patients are stigmatized at work due to their appearance. METHODS: Sixty one patients with AIBD completed the Work Productivity and Activity Impairment Questionnaire-Specific Health Problem (WPAIQ-SHP), the Dermatology Life Quality Index (DLQI), the Autoimmune Bullous Disease Quality of Life (ABQOL), and the Treatment of Autoimmune Bullous Disease Quality of Life questionnaires (TABQOL)...
May 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29730890/local-radio-and-local-newspaper-best-methods-to-reach-older-male-population-for-euromelanoma-campaign-in-ireland
#15
L Griffin, D Roche, L Roche, M Murphy
The incidence of melanoma is increasing in Ireland and worldwide with higher rates of increase in Irish men (5% per year) compared to women (2.3% per year). Fortunately, overall mortality rates are not growing to the same extent especially in women, where mortality rates have flattened. Irish males, however, tend to present at a later stage with thicker tumors and have lower survival rates with the hazard ratio for men 61% greater than women when all other factors were allowed for. Survival from melanoma has been shown to be lower in men suggesting differences in tumour-host interaction across gender...
May 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29730889/outdoor-environment-ozone-radionuclide-associated-aerosols-and-incidences-of-infantile-eczema-in-minsk-belarus
#16
I N Belugina, N Z Yagovdik, O S Belugina, S N Belugin
BACKGROUND: The early occurrence of atopic dermatitis in infants may be influenced by urban air pollution. OBJECTIVE: The aim of this study was to determine the relationship between incidences of infantile eczema in children under 2 years of age and urban outdoor environmental factors. METHODS: A 11-year population based study was conducted in retrospective design. The age/gender adjusted incidence rates of infantile eczema were determined using the data of outpatient visits...
May 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29730888/patient-perceptions-of-clear-almost-clear-skin-in-moderate-to-severe-plaque-psoriasis-results-of-the-clear-about-psoriasis-worldwide-survey
#17
A Armstrong, S Jarvis, W-H Boehncke, M Rajagopalan, P Fernández-Peñas, R Romiti, A Bewley, B Vaid, L Huneault, T Fox, M Sodha, R B Warren
BACKGROUND: Therapeutic advances have made the achievement of clear/almost clear skin possible for many patients with moderate-to-severe plaque psoriasis. OBJECTIVE: To determine patient perceptions of the impact of psoriasis and of attaining clear/almost clear skin. METHODS: Global survey of patients with moderate-to-severe psoriasis. RESULTS: 8338 patients from 31 countries participated. The majority (57%) had not achieved self-assessed clear/almost clear skin with their current therapy, and 56% of those who had not met this goal believed it would be impossible to do so...
May 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29730887/drug-induced-longitudinal-melanonychia-and-transverse-muerhcke-s-lines
#18
N di Meo, M Longone, R Chiara, I Zalaudek
We describe the case of a 60 years old woman, who came to our attention in November 2017. She was worried about a "dark line" which had recently developed on the second finger nail of the right hand. The patient had a medical history of infiltrating ductal carcinoma of the breast and she had received in the Spring of 2017 six courses of adjuvant chemotherapy with Docetaxel and Cyclophosphamide, later in October 2017 she had started a hormonal therapy with Letrozole. This article is protected by copyright...
May 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29730886/primary-syphilis-occurring-as-extensive-ulceration-on-the-palatal-gingival-mucosa-diagnosed-by-immunohistochemical-stain
#19
Norberto Sugaya, Paulo H Braz-Silva, Mariana L Bergamini, Dante Migliari
Syphilis is an infectious disease caused by Treponema pallidum, a spirochete microorganism that is pathogenic only to humans. Its transmission occurs predominantly by sexual contact. Clinically, it has four stages: primary, secondary, latent, and tertiary. In most instances, the diagnosis is made during the secondary stage, on which lesions are more numerous, symptomatic, and may affect skin and mucosa areas simultaneously. On the other hand, the primary stage manifests by single, usually painless, ulceration that goes into spontaneously healing between 2 to 4 weeks after its appearance...
May 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29730885/adverse-events-associated-with-apremilast-use-and-withdrawal-for-psoriasis-in-a-real-world-setting
#20
Erica B Lee, Mina Amin, Alexander Egeberg, Jashin J Wu
Apremilast, a phosphodiesterase-4 inhibitor, is an oral therapy for treatment of psoriasis. Its safety profile is favorable, with side effects including diarrhea, nausea, vomiting, depression, and weight decrease, primarily based on clinical trial data. However, limited research exists on the side effect frequency and subsequent adverse events (AEs) in real-world practice. This retrospective chart review included patients who presented to the dermatology clinic at Kaiser Permanente Los Angeles Medical Center and were treated with apremilast at any time between January 1, 2015 and January 11, 2018...
May 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
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