journal
MENU ▼
Read by QxMD icon Read
search

Journal of the European Academy of Dermatology and Venereology: JEADV

journal
https://www.readbyqxmd.com/read/28815749/commentary-estrogen-receptor-expression-in-melanoma
#1
E Ramelyte, P Koelblinger, R Dummer
Sexual hormones share a common cholesterol derived steroid backbone and comprise estrogens, gestagens and androgens. They elicit numerous physiological and pathological functions; e.g. androgens are known to contribute to prostatic cancer development, whereas estrogens are of major importance in the pathogenesis of breast cancer. In 1986, presence of estrogen receptors (ER) on breast cancer cells was described as one of the first biomarkers in oncology [1]. This article is protected by copyright. All rights reserved...
August 16, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28796927/epithelial-to-mesenchymal-transition-contributes-to-invasion-in-squamous-cell-carcinomas-originated-from-actinic-keratosis-through-the-differentiated-pathway-whereas-proliferation-plays-a-more-significant-role-in-the-classical-pathway
#2
X Saenz-Sardà, C Carrato, L Pérez-Roca, L Puig, C Ferrándiz, A Ariza, M T Fernández-Figueras
BACKGROUND: Every actinic keratosis (AK) starts with atypia at the basal layers of the epidermis (AK I). Progression into invasive squamous cell carcinoma (iSCC) may occur following two main pathways, classical and differentiated. In the former, iSCC only occurs after involvement of the upper epidermal layers by atypical cells (AK III), while in the latter iSCC develops directly from AK I. In the anogenital mucosa, these two pathways are associated with differential expression of p53 and p16...
August 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28796920/recommendations-for-the-management-of-comorbidity-in-hidradenitis-suppurativa
#3
E Dauden, P Lazaro, M D Aguilar, A J Blasco, C Suarez, I Marin, R Queiro, J Bassas-Vila, A Martorell, J García-Campayo
BACKGROUND: The association between hidradenitis suppurativa (HS) and some diseases is becoming relevant in recent years. Providing appropriate management of HS from an early stage requires to include prompt diagnosis and treatment of concomitant diseases and to prevent any potential comorbidity. This approach should consider the adverse events of the drugs used to treat HS potentially related to the onset of a comorbidity. OBJECTIVE: To provide the dermatologist with an accurate, easily used tool that will inform the diagnosis of HS comorbidity, and to facilitate decision-making regarding the referral and treatment of patient with HS-associated comorbidity...
August 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28796916/fragrance-contact-allergens-in-5-588-cosmetic-products-identified-through-a-novel-smartphone-application
#4
Niels Højsager Bennike, Nikoline Bang Oturai, Stine Müller, Christel Søgaard Kirkeby, Claus Jørgensen, Anne Beck Christensen, Claus Zachariae, Jeanne Duus Johansen
BACKGROUND: More than 25% of the adult European population suffers from contact allergy, with fragrance substances recognized as one of the main causes. Since 2005, 26 fragrance contact allergens have been mandatory to label in cosmetic products within the EU if present at 10 ppm or above in leave-on and 100 ppm or above in wash-off cosmetics. OBJECTIVE: To examine exposure, based on ingredient labelling, to the 26 fragrances in a sample of 5,588 fragranced cosmetic products...
August 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28796915/clearance-in-vulvar-lichen-sclerosus-a-realistic-treatment-endpoint-or-a-chimera
#5
A Borghi, A Virgili, S Minghetti, G Toni, M Corazza
BACKGROUND: according to the current guidelines, the aim of vulvar lichen sclerosus (VLS) treatment is to improve symptoms and signs, not to cure. OBJECTIVE: to assess i) the rate of VLS patients who achieved complete clearance of symptoms or objective features, or both, with a 12-week pharmacological treatment and ii) the predictive value of therapeutic response of the demographic and clinical features. METHODS: we retrospectively included VLS patients who had undergone any topical treatment for 12 weeks; demographics, history, VLS-related symptoms and objective features recorded at baseline and on completion of treatment were collected and elaborated...
August 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28796914/actinic-keratoses-show-variable-histological-basal-growth-patterns-a-proposed-classification-adjustment
#6
L Schmitz, T Gambichler, G Gupta, M Stücker, E Stockfleth, R M Szeimies, T Dirschka
BACKGROUND: Common histological classification schemes of actinic keratoses (AK) do not evaluate growth patterns at basal epidermal aspects of AK. Until now, the importance of basal epidermal growth patterns of AK has not been studied. OBJECTIVE: To investigate the extent of atypical keratinocytes throughout the epidermis and variation in basal growth patterns of AK. METHODS: AK lesions occurring on the head/face from patients seen in routine practice were assessed histologically...
August 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28796913/patients-with-psoriasis-have-different-preferences-for-topical-therapy-highlighting-the-importance-of-individualized-treatment-approaches-randomized-phase-iiib-pso-insightful-study
#7
C-H Hong, K A Papp, K W Lophaven, P Skallerup, S Philipp
BACKGROUND: Poor adherence to topical therapy in psoriasis remains an issue; it is associated with poor clinical outcomes, reduced quality of life, and increased costs. Treatment-related factors leading to poor adherence include lack of efficacy, excessive time applying medication, and poor cosmetic characteristics (e.g. slow absorption, greasiness). OBJECTIVE: To assess the topical treatment attributes that influence patient preference for fixed combination calcipotriol 50 μg/g (Cal) and betamethasone 0...
August 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28796910/factors-predicting-the-self-evaluated-health-of-hidradenitis-suppurativa-patients-recruited-from-an-outpatient-clinic
#8
R Kjaersgaard Andersen, P Theut Riis, G B E Jemec
OBJECTIVES: In recent years, Hidradenitis suppurativa has received increased attention, but still lack well-defined, robust patient reported outcome measures. Such measures are likely to be influenced by contextual factors. We therefore aim to describe the association of biological and other factors with HS patient's self-evaluated health as reflected by the EQ5D VAS score. METHODS: This cross-sectional study measured basic information, Dermatology Life Quality Index, Major Depression Inventory, and Euro-QoL-5D...
August 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28792092/european-dermatology-forum-s1-guideline-on-the-diagnosis-and-treatment-of-sclerosing-diseases-of-the-skin-part-1-localized-scleroderma-systemic-sclerosis-and-overlap-syndromes
#9
LETTER
R Knobler, P Moinzadeh, N Hunzelmann, A Kreuter, A Cozzio, L Mouthon, M Cutolo, F Rongioletti, C P Denton, L Rudnicka, L A Frasin, V Smith, A Gabrielli, E Aberer, M Bagot, G Bali, J Bouaziz, A Braae Olesen, I Foeldvari, C Frances, A Jalili, U Just, V Kähäri, S Kárpáti, K Kofoed, D Krasowska, M Olszewska, C Orteu, J Panelius, A Parodi, A Petit, P Quaglino, A Ranki, J M Sanchez Schmidt, J Seneschal, A Skrok, M Sticherling, C Sunderkötter, A Taieb, A Tanew, P Wolf, M Worm, N J Wutte, T Krieg
The term 'sclerosing diseases of the skin' comprises specific dermatological entities, which have fibrotic changes of the skin in common. These diseases mostly manifest in different clinical subtypes according to cutaneous and extracutaneous involvement and can sometimes be difficult to distinguish from each other. The present guideline focuses on characteristic clinical and histopathological features, diagnostic scores and the serum autoantibodies most useful for differential diagnosis. In addition, current strategies in the first- and advanced-line therapy of sclerosing skin diseases are addressed in detail...
August 9, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28786499/european-dermatology-forum-s1-guideline-on-the-diagnosis-and-treatment-of-sclerosing-diseases-of-the-skin-part-2-scleromyxedema-scleredema-and-nephrogenic-systemic-fibrosis
#10
R Knobler, P Moinzadeh, N Hunzelmann, A Kreuter, A Cozzio, L Mouthon, M Cutolo, F Rongioletti, C P Denton, L Rudnicka, L A Frasin, V Smith, A Gabrielli, E Aberer, M Bagot, G Bali, J Bouaziz, A Braae Olesen, I Foeldvari, C Frances, A Jalili, U Just, V Kähäri, S Kárpáti, K Kofoed, D Krasowska, M Olszewska, C Orteu, J Panelius, A Parodi, A Petit, P Quaglino, A Ranki, J M Sanchez Schmidt, J Seneschal, A Skrok, M Sticherling, C Sunderkötter, A Taieb, A Tanew, P Wolf, M Worm, N J Wutte, T Krieg
The term 'sclerosing diseases of the skin' comprises specific dermatological entities which have fibrotic changes of the skin in common. These diseases mostly manifest in different clinical subtypes according to cutaneous and extracutaneous involvement and can sometimes be difficult to distinguish from each other. The present guideline focuses on characteristic clinical and histopathological features, diagnostic scores and the serum autoantibodies most useful for differential diagnosis. In addition, current strategies in the first- and advanced-line therapy of sclerosing skin diseases are addressed in detail...
August 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28779501/response-to-eruptive-keratoacanthomas-arising-in-the-setting-of-lichenoid-toxicity-after-pd1-inhibition-with-nivolumab
#11
Justin P Bandino, Dirk M Elston
We thank Dr. Fung and colleagues for their interest in our publication concerning eruptive keratoacanthomas (KAs) and bullous pemphigoid-like disease in patients on anti-programmed cell death-1 (PD-1) immunotherapy.(1) We agree that nivolumab, like pembrolizumab, seems to share the same immune-related adverse event profile, and in fact our second case occurred in a patient on nivolumab (after no visible reduction in metastatic disease on pembrolizumab). This article is protected by copyright. All rights reserved...
August 5, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28776776/ten-treatment-without-immunosuppressive-therapy-in-a-burn-centre-a-series-of-10-cases
#12
P Gacto, J J Pereyra, J Carbajal, T Gomez-Cía, J Conejo-Mir
Toxic epidermal necrolysis (TEN) is a serious and infrequent skin disease, usually secondary to drugs. Since the disease includes severe exfoliative disease it has been treated in Burn Centers due to large skin losses. The mechanism leading to the development of lesions is not fully known; the main role is attributed to dysfunction of T lymphocytes (1). The mortality, ranging from 10% to 70% (2), predominantly results from severe complications of multiple organ failure and infections affecting extensive areas of inflamed skin...
August 4, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28776772/dynamic-optical-coherence-tomography-of-skin-blood-vessels-proposed-terminology-and-practical-guidelines
#13
M Ulrich, L Themstrup, N de Carvalho, S Ciardo, J Holmes, R Whitehead, J Welzel, G B E Jemec, G Pellacani
BACKGROUND: Dynamic optical coherence tomography (D-OCT) has recently been introduced in dermatology. In contrast to 'Standard' OCT imaging, which exclusively relies on the morphological analysis of the tissue, D-OCT allows the in-vivo visualisation of blood flow. Preliminary D-OCT data showed differences in the vascularisation of nevus to melanoma transition, suggesting that this technology may help to differentiate between benign and malignant lesions. OBJECTIVE: Several factors may influence the quality of D-OCT imaging...
August 4, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28776768/atypical-presentation-of-enterovirus-infection-in-adults-outbreak-of-hand-foot-mouth-and-scalp-disease-in-northern-italy
#14
R Balestri, M Bellino, L Landini, L Tasin, L Rizzoli, L Speziali, P Bauer, M C Sicher, G Rech, C R Girardelli
We read with great interest the article entitled 'Hand, foot and mouth disease: an overview of clinical features in adult patients' published by I. Neri et al. in the JEADV, in which the authors reported the atypical features of hand, foot and mouth disease (HFMD)observed over 16 months. We recently witnessed an outbreak of atypical HFDM with well defined features, almost exclusively affecting adults, and we would therefore like to report and compare our experience. This article is protected by copyright. All rights reserved...
August 4, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28776782/%C3%A2-%C3%A2-malignant%C3%A2-%C3%A2-rosacea-as-a-sign-of-systemic-marginal-zone-lymphoma
#15
A Lamoureux, Béatrice Vergier, Gladys Fidelin-Ferrati, Pierrick Hans, Noel Milpied, Marie Beylot-Barry
Rosacea is a common facial dermatosis for which differential diagnoses have to be considered in the case of atypical features or treatment failure. We report 3 cases of systemic marginal zone lymphomas (MZL), with skin involvement simulating rosacea. A 76-year-old man presented a rhinophyma for one year (Fig 1). This article is protected by copyright. All rights reserved.
August 3, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28776778/eruptive-keratoacanthomas-arising-in-the-setting-of-lichenoid-toxicity-after-pd1-inhibition-with-nivolumab
#16
Stephanie I Feldstein, Forum Patel, Larissa Larsen, Edward Kim, Samuel Hwang, Maxwell A Fung
We were fascinated to read the observations of Bandino et al. who described two patients who developed keratoacanthomas and squamous cell carcinoma in association with bullous pemphigoid-like lesions after treatment with PD-1 inhibitors, nivolumab or pembrolizumab, in a recent issue of the Journal. Herein we report two patients with no prior history of skin cancer who developed eruptive keratoacanthomas in the setting of lichenoid skin toxicity after starting nivolumab. This article is protected by copyright...
August 3, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28776773/hand-foot-and-mouth-disease-in-adult-patients
#17
I Neri, M A Chessa, A Virdi, A Patrizi
We read with great interest the paper by Balestri et al(1) "atypical presentation of enterovirus infection in adults: outbreak of Hand, Foot, Mouth and Scalp disease in Northern Italy" which confirms the adult involvement in hand, foot and mouth disease (HFMD). This article is protected by copyright. All rights reserved.
August 3, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28776770/cutaneous-leishmaniasis-by-leishmania-infantum-behind-granulomatous-lesions-of-unknown-etiology
#18
G Merino-Espinosa, V Corpas-López, V Díaz-Sáez, F Morillas-Márquez, J Tercedor-Sánchez, J M Azaña-Defez, J López-Hidalgo, J Aneiros-Fernández, J Martín-Sánchez
BACKGROUND: Cutaneous leishmaniasis (CL) is underestimated in Spain as in other European countries due to the polymorphism of its clinical manifestations and histopathological features discouraging doctors from suspecting leishmaniasis. Mucosal manifestations (ML) are misdiagnosed due to the fact that they often mimic cancer. OBJECTIVES: Given that leishmaniasis may be masked as different granulomatous diseases in Leishmania infantum endemic areas, the aim of this study is to verify this misdiagnosing and contribute to the improvement of CL/ML diagnosis...
August 3, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28776767/applying-behavioral-economics-to-psoriasis-treatment-interventions-to-improve-patient-adherence-to-biologics
#19
Daniel J Lewis, Leah A Cardwell, Steven R Feldman
Zschocke et al(1) identified factors associated with adherence to biologics for psoriasis. The physician-patient relationship influences adherence considerably.(1) Specific interventions may increase adherence to biologics. This article is protected by copyright. All rights reserved.
August 3, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28758268/noodle-pattern-a-new-dermoscopic-pattern-for-crusted-scabies-norwegian-scabies
#20
Sonia Chavez-Alvarez, Alejandra Villarreal-Martinez, Giuseppe Argenziano, Jesus Ancer-Arellano, Jorge Ocampo-Candiani
A 36-year-old female patient with HIV infection and poor treatment adherence was seen due to a skin rash that was affecting mainly her trunk and extremities. Lesions consisted of non-pruriginous papules, hyperkeratotic plaques, and desquamation (Fig 1). Upon dermoscopic examination (10x, DermLite DL3N, San Juan Capistrano, CA, USA), the lesions exhibited a hyperkeratotic appearance, and the centre was composed of several burrows on top of each other in a noodle-like pattern. This article is protected by copyright...
July 31, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
journal
journal
31187
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"