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Journal of the European Academy of Dermatology and Venereology: JEADV

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https://www.readbyqxmd.com/read/28430376/acute-generalized-exanthematous-pustulosis-associated-with-ipilimumab-and-nivolumab
#1
Basile Page, Luca G Borradori, Helmut Beltraminelli, Nikhil Yawalkar, Robert E Hunger
Acute generalized exanthematous pustulosis (AGEP) is a rare potentially severe adverse cutaneous eruption, that is usually induced by a variety of drugs, most commonly anti-bacterial drugs. AGEP is characterized by the acute development of extensive, non-follicular, sterile pustules on an erythematous background accompanied by systemic symptoms such as fever and leucocytosis.¹ The prognosis is usually favourable, but in elderly patients with comorbidities morbidity and mortality are increased.² This article is protected by copyright...
April 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28426924/high-dose-pulsed-corticosteroid-therapy-combined-with-methotrexate-for-severe-alopecia-areata-of-childhood
#2
J H Chong, A Taïeb, F Morice-Picard, A S Dutkiewicz, C Léauté-Labrèze, F Boralevi
Alopecia areata (AA) in childhood can run a chronic course and worsen over time(1). Spontaneous hair regrowth is rarely appreciated in chronic severe AA(2-4). Our centre described the ineffective use of high dose pulsed corticosteroid therapy (HDPCT) in the long term(1). Methotrexate (MTX) as a maintenance therapy following HDPCT showed some success in adults(5). Although the evidence for using either drug individually was weak(6), the combination of using both was not well studied. This article is protected by copyright...
April 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28426907/frontal-fibrosing-alopecia-clinical-and-prognostic-classification
#3
O M Moreno-Arrones, D Saceda-Corralo, P Fonda-Pascual, A R Rodrigues-Barata, D Buendía-Castaño, A Alegre-Sánchez, C Pindado-Ortega, M Molins, D Perosanz, G Segurado-Miravalles, P Jaén, S Vañó-Galván
BACKGROUND: Frontal fibrosing alopecia (FFA) is a chronic scarring alopecia with an unpredictable evolution. There are no current classifications of this disease that may predict its prognosis. OBJECTIVE: To analyze the differences in clinical presentation and evolution of FFA patients and to create a clinical and prognostic classification METHODS: We conducted a retrospective analytical study of FFA patients. Clinical characteristics of frontal hairline recession were used as the sorting variable between patterns of presentation...
April 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28426906/measuring-the-impact-of-dermatological-conditions-on-family-and-caregivers-a-review-of-dermatology-specific-instruments
#4
REVIEW
F Sampogna, A Y Finlay, S S Salek, P Chernyshov, F J Dalgard, A W M Evers, D Linder, L Manolache, S E Marron, F Poot, S Spillekom-van Koulil, Å Svensson, J C Szepietowski, L Tomas-Aragones, D Abeni
The patient is the centre of a web of relationships and the impact of his/her disease on family members and caregivers must be taken into account. The aim of this study was to identify the specific instruments that measure the impact of a dermatological disease on the quality of life (QoL) of family members, by performing a systematic search of the literature. Fifteen papers were identified, describing the creation and validation of nine instruments. Four of them concerned atopic dermatitis (Dermatitis Family Index, DFI; Parents' Index QoL Atopic Dermatitis, PiQoL-AD; QoL in Primary Caregivers of children with Atopic Dermatitis, QPCAD; Childhood Atopic Dermatits Impact Scale, CADIS), two measured the impact of psoriasis in family members (Psoriasis Family Index, PFI; FamilyPso), one the impact of epidermolysis bullosa (Epidermolysis Bullosa Burden of Disease, EB-BoD), one of ichthyosis (Family Burden Ichthyosis, FBI), and one was generic for dermatological conditions (Family Dermatology Life Quality Index, FDLQI)...
April 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28426905/acantholytic-dyskeratotic-acanthoma-a-possible-skin-adverse-event-of-vemurafenib-treatment
#5
Takaya Komori, Atsushi Otsuka, Yo Kaku, Tetsuya Honda, Kenji Kabashima
Acantholytic dyskeratotic acanthoma (ADA) is a solitary small papule that is pathologically characterized by dyskeratosis with acantholytic acanthosis (1). Vemulafenib is a specific inhibitor of BRAF protein kinase with V600E mutation and is administered to treat metastatic melanoma. Various skin adverse events associated with vemurafenib, including acantholysis and flare up of Darier's disease, have been reported (2, 3). Here we report a case of ADA that developed during vemulafenib treatment for metastatic melanoma...
April 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28426901/a-case-of-toxic-epidermal-necrolysis-and-vanishing-bile-duct-syndrome-requiring-liver-transplantation
#6
Sophie Momen, Carol Dangiosse, Emma Wedgeworth, Sarah Walsh, Daniel Creamer
A 52-year-old woman presented with a five-day history of headache, fevers and a diffuse, macular erythematous rash. Ten days prior she received cephalexin for a urinary-tract infection. She had a history of gastro-oesophageal reflux disorder and took omeprazole. This article is protected by copyright. All rights reserved.
April 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28426900/videodermoscopy-supports-the-diagnosis-of-eyelash-trichotillomania
#7
M Sławińska, A Opalska, D Mehrholz, M Sobjanek, R Nowicki, W Barańska-Rybak
37-year-old woman presented with extensive erythematous and ulcerative eruptions on the face and chest with concomitant isolated eyelash alopecia. Skin problems started during adolescence; eyelash loss several years before hospital admission. This article is protected by copyright. All rights reserved.
April 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28426899/ultrasonographic-features-of-intravascular-fasciitis-case-report-and-review-of-the-literature
#8
K Takahashi, T Yanagi, K Imafuku, S Kitamura, Y Inamura-Takashima, Y Yamaguchi, H Hata, H Shimizu
Intravascular fasciitis (IF), a variant of nodular fasciitis (NF), is a reactive intravascular proliferation of myofibroblasts. IF is an indolent subcutaneous or intramuscular nodule that is most commonly found on the extremities, head and neck.(1, 2) This article is protected by copyright. All rights reserved.
April 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28426893/diffuse-normolipemic-plane-xanthoma-on-striae
#9
C Baykal, Z Yılmaz, N Büyükbabani
Diffuse normolipemic plane xanthoma (DNPX) is a rare skin disorder characterized by the presence of symmetric, asymptomatic, flat, yellow plaques of different size.(1) As it is commonly located on the eyelids, xanthelesma may be a differential diagnostic consideration, but the lesions of DNPX are usually larger and other parts of the face, neck, flexural folds and trunk may also be involved.(1) This article is protected by copyright. All rights reserved.
April 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28426138/incremental-burden-of-cardiovascular-comorbidity-and-psoriatic-arthritis-among-adults-with-moderate-to-severe-psoriasis-in-five-european-countries
#10
M Augustin, J Vietri, H Tian, I Gilloteau
BACKGROUND: Moderate-to-severe psoriasis is associated with reduced health-related quality of life (HRQoL). Individuals with psoriasis are at increased risk for other medical conditions, but little information quantifies the incremental burden of psoriasis-associated comorbidity among European adults, and data have generally been limited to clinical samples. OBJECTIVE: To quantify the incremental burden of cardiovascular comorbidity and psoriatic arthritis among adults with moderate-to-severe psoriasis in the general population of France, Germany, Italy, Spain, and the United Kingdom (EU5)...
April 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28423206/folic-acid-who-does-what-with-methotrexate
#11
A Randhawa, R Blair, G Wylie
Methotrexate is a folic acid derivative that inhibits dihydrofolate reductase which has effects on DNA synthesis and cellular replication. In Dermatology, it is licensed for use in recalcitrant psoriasis but is also used off-label in many other conditions.(1) It is given either orally or by subcutaneous injection. Folic acid is usually prescribed alongside methotrexate but there is often variation in prescribing practice. This article is protected by copyright. All rights reserved.
April 17, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28419674/prognostic-risk-factors-of-first-recurrence-in-patients-with-primary-stage-i-ii-cutaneous-malignant-melanoma-from-the-population-based-swedish-melanoma-register
#12
J Lyth, M Falk, M Maroti, H Eriksson, C Ingvar
BACKGROUND: Prognostic factors in patients with localised primary cutaneous malignant melanoma (CMM) are well described. However, prognostic factors for recurrence are less documented. OBJECTIVES: The aim of this study was to identify prognostic risk factors for first recurrence in patients with localised stage I-II CMM using population-based data. METHODS: This study included 1 437 CMM patients registered in one region of Sweden during 1999-2012 followed-up through December 31, 2012...
April 17, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28419600/reformulations-of-well-known-active-ingredients-in-the-topical-treatment-of-psoriasis-vulgaris-can-improve-clinical-outcomes-for-patients
#13
REVIEW
L Iversen, E Dauden, S Segaert, K Freeman, S Magina, D Rigopoulos, D Thaci
BACKGROUND: Although the majority of patients with psoriasis vulgaris are treated exclusively with topical therapies, research to develop more effective topical therapies that are associated with higher patient satisfaction has lagged behind the development of systemic agents. OBJECTIVE: The aim of this literature review was to determine whether there is documented evidence that applying an innovative approach to improving the formulation of active ingredients commonly used in the topical treatment of psoriasis can have a positive effect on clinical outcomes and patient-reported outcomes (PROs)...
April 17, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28419575/prepubertal-vulvar-fibroma-a-rare-entity-little-known-to-dermatologists-report-of-two-cases
#14
S Nguyen, S Fraitag, N Cardot-Leccia, S Lagrange, C Trastour, T Passeron, S Croce, J M Coindre, J P Lacour, H Montaudié
Prepubertal vulvar tumors are rare and may represent mesenchymal tumors, hamartomas, or vascular malformations. Their presentation may be similar but they do not have the same prognosis and management. We report 2 cases of labium majus hypertrophy corresponding to prepubertal vulvar fibromas. This article is protected by copyright. All rights reserved.
April 17, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28419572/genome-wide-differential-expression-profiling-of-long-non-coding-rnas-in-androgenetic-alopecia-in-a-chinese-male-population
#15
Linlin Bao, Aijiao Yu, Yaojia Luo, Tian Tian, Yuxi Dong, Haifeng Zong, Hongduo Chen, Xinghua Gao, Xuegang Xu, Yuanhong Li
BACKGROUND: Androgenetic alopecia (AGA), or male pattern baldness (MPB), is the most common form of hair loss in males. A combination of genetic and androgen causes have been suggested as factors that contribute to the development of AGA. However, the specific molecular mechanisms that underly AGA remain largely unknown. Long noncoding RNAs (lncRNAs), a new class of regulatory noncoding RNAs that are longer than 200 nucleotides, have been shown to play important roles in a number of cellular processes, including transcription, chromosome remodelling, and posttranscriptional processing...
April 17, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28419570/oral-lichenoid-reactions-associated-with-anti-pd-1-pd-l1-therapies-clinicopathological-findings
#16
V Sibaud, C Eid, V R Belum, P Combemale, B Barres, L Lamant, L Mourey, C Gomez-Roca, C L Estilo, R Motzer, E Vigarios, Mario E Lacouture
Immune checkpoint inhibitors targeting the programmed cell death receptor-1 (PD-1) or its ligand (PD-L1) show broad activity across different tumor types and currently represent one of the keystones of cancer management. Dermatologic toxicities are one of the most frequent immune-related adverse events (irAEs) induced by these new monoclonal antibodies. Maculopapular rash, pruritus, exacerbation of psoriasis or more specific autoimmune disorders (e.g. vitiligo, alopecia areata, and bullous pemphigoid) are amongst the most commonly reported AEs...
April 17, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28419569/lava-lake-structure-and-cloud-like-structureless-area-new-clues-for-diagnosing-extramammary-paget-disease
#17
K Payapvipapong, A Nakakes, M Tanaka
Extramammary Paget disease (EMPD) is a rare malignant skin neoplasm mostly found in the genital area. Its clinical and histopathological features are similar to mammary Paget disease. The clinical differential diagnosis includes various skin diseases. The dermoscopic findings of EMPD have been described in the literature. This article is protected by copyright. All rights reserved.
April 17, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28414878/do-outdoor-workers-know-their-risk-of-nmsc-perceptions-beliefs-and-preventive-behaviour-among-farmers-roofers-and-gardeners
#18
A Zink, D Wurstbauer, M Rotter, M Wildner, T Biedermann
BACKGROUND: Non-melanoma skin cancer (NMSC) was officially recognized in 2015 as an occupational disease for outdoor workers in Germany. Together with the enormous socioeconomic impact of NMSC, this has led to the continuous demand of evidence-based prevention. However, studies assessing the perceptions and beliefs along with risk behavior of outdoor workers as an essential prerequisite for prevention are rare. OBJECTIVE: To assess perceptions, beliefs, barriers, risk and preventive behavior towards non-melanoma skin cancer among different outdoor groups as a basis for the development of sustainable prevention programs...
April 17, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28403528/superficial-black-onychomycosis-due-to-neoscytalidium-dimidiatum
#19
N Di Chiacchio, L F Noriega, N Gioia Di Chiacchio, J Ocampo-Garza
Onychomycosis is the most common onychopathy observed in adults and the elderly, and it is a frequent reason for medical visits.(1) Its prevalence ranges from 2.0-26.9%, depending on the population and geographic region.(1,2) Non-dermatophyte molds are responsible for 1.5-17.6% of onychomycosis cases, with higher prevalence in tropical and subtropical countries. This article is protected by copyright. All rights reserved.
April 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28403511/decrease-of-serum-il-32-level-in-patients-with-atopic-dermatitis-after-cyclosporine-treatment
#20
Naomi Kitayama, Atsushi Otsuka, Yumi Nonomura, Chisa Nakashima, Tetsuya Honda, Kenji Kabashima
Interleukin (IL)-32 is a proinflammatory cytokine that is involved in the inflammatory processes of rheumatoid arthritis, chronic obstructive pulmonary disease, and Crohn disease. [1] Recent studies have reported that IL-32 also contributes to the pathophysiology of atopic dermatitis (AD) in the early stages. [2] IL-32 is expressed in the lesional skin of patients with AD and that serum levels of IL-32 in patients with AD are elevated. This article is protected by copyright. All rights reserved.
April 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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