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Journal of the European Academy of Dermatology and Venereology: JEADV

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https://www.readbyqxmd.com/read/29314428/mosaic-nrasopathy-n-a-child-with-giant-melanocytic-congenital-naevus-epidermal-hamartoma-and-bilateral-nephroblastomatosis-clinical-implication-for-follow-up
#1
C Maridet, F Morice-Picard, A Gros, L Crivelli, A de la Fouchardière, B Vergier, A Taïeb
Various nevoid proliferations result from postzygotic mutation in genes within the RAF/RAS/MAPK pathway, supporting the term "mosaic RASopathy"(1). Giant congenital melanocytic naevus (GCMN) and neurocutaneous melanosis are rare mosaic RASopathies mainly known to be at risk for the development of melanoma and skeletal anomalies are variably recorded (2,3). This article is protected by copyright. All rights reserved.
January 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29314333/programmed-cell-death-1-blockade-induced-cutaneous-sarcoid-like-epithelioid-granulomas-in-advanced-melanoma-a-case-report
#2
T Ogawa, Y Ishitsuka, K Iwamoto, H Koguchi-Yoshioka, R Tanaka, R Watanabe, Y Fujisawa, M Fujimoto
Sarcoidosis is a chronic, systemic inflammatory disorder of unknown etiology that is characterized by the formation of noncaseating granuloma in affected organs, most commonly the lung.1 In pulmonary sarcoidosis patients, the T helper 1 (Th1) cytokine profile of CD4+ as well as CD8+ T cells was demonstrated in bronchoalveolar lavage fluid.2 However, there has been no detailed description of a lymphocyte profile in cutaneous sarcoid-like epithelioid granulomas. Here, we report a case of sarcoid-like epithelioid granulomas induced by nivolumab in a patient with advanced melanoma and we performed functional lymphocyte analysis of the granuloma lesions...
January 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29314302/toxic-epidermal-necrolysis-a-review-of-20-years-of-data
#3
Mark C Marchitto, Sarah Sung, Judy Doong, Anna L Chien
Toxic epidermal necrolysis (TEN) is a rare, yet life-threatening immune-mediated mucocutaneous disorder often occurring in the context of a newly administered medication. The cutaneous manifestations are characterized by extensive epidermal detachment, mucosal surface erosion, and multi-organ damage (1-2). This article is protected by copyright. All rights reserved.
January 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29314294/participation-of-the-th17-response-in-the-pathogenesis-of-oral-lichen-planus
#4
R A Melo, L A B Silva, A N Fernades-Costa, B V B Monteiro, E J D Silveira, M C C Miguel
Lichen planus is a chronic noninfectious inflammatory mucocutaneous disease that affects the skin, nails and mucosae, including the oral mucosa.1 Although the etiology of oral liquen planus (OLP) remains not fully elucidated, it is recognized that its pathogenesis arises from an immune-mediated response and many authors suggest the disease to be an autoimmune process.2-5 Despite the high prevalence and well-defined cytotoxic activity of CD8+ T lymphocytes against keratinocytes of the basal layer of the epithelium in OLP, helper CD4+ T lymphocytes also play an important role in the pathogenesis of this disease...
January 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29314292/examination-of-the-melanocytes-of-the-nevus-of-ota-with-in-vivo-reflectance-confocal-microscopy-15-cases
#5
Christoph Grechenig, Elisa Cinotti, Bruno Labeille, Gerald Langmann, Jean Luc Perrot, Olivia Schatz, Lisa Tarmann, Andreas Wedrich, Werner Wackernagel, Iris Zalaudek, Johannes Haybaeck, Christoph Schwab
The Nevus of Ota (NO) is a bluish or greyish hyperpigmentation caused by an accumulation of dermal melanocytes that typically extend to the innervated parts of the ophthalmic and maxillary divisions of the trigeminal nerve, involving the facial skin, the uvea, the iris and the sclera (Figure 1). This article is protected by copyright. All rights reserved.
January 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29314288/the-limitations-of-dermoscopy-false-positive-and-false-negative-tumors
#6
REVIEW
V Papageorgiou, Z Apalla, E Sotiriou, C Papageorgiou, E Lazaridou, S Vakirlis, D Ioannides, A Lallas
Dermoscopy has been documented to increase the diagnostic accuracy of clinicians evaluating skin tumors, improving their ability to detect skin cancer and better recognize benign moles. However, dermoscopically "false positive" and "false negative" tumors do exist. False positive diagnosis usually leads to unnecessary excisions. False negative diagnosis is much more dangerous, since it might result in overlooking a cancer, with severe undesirable consequences for the patient and the physician. Therefore, management strategies should mainly focus on addressing the risk of dermoscopically false negative tumors...
January 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29314277/erasmus-syndrome-associated-with-an-immune-thrombocytopenic-purpura
#7
Maxime Fouchard, Brigitte Pan Petesch, Claire Abasq-Thomas, Alain Saraux, Laurent Misery, Emilie Brenaut
We report the observation of a 57-year-old patient followed for an Erasmus syndrome (a systemic sclerosis developing secondary to silica exposure) (1) diagnosed in 2002 after being exposed as a dental technician, for whom a severe thrombocytopenia was discovered. He suffered from a pulmonary fibrosis, polyarthralgia, esophageal dysphagia and cutaneous involvement such as finger ulcerations and sclerodactylia. The treatment was made of nifedipine 30mg/day, esomeprazole 20mg/day and bosentan 25 mg twice a day...
January 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29314272/eruptive-nevi-under-tocilizumab-first-case-report-and-data-analysis
#8
Y Mansour, A Lambert, M Tebacher-Alt, J L Pasquali, D Lipsker
we would like to draw attention to an unusual side effect of tocilizumab (TOC), a humanized monoclonal antibody directed against the interleukin 6 (IL-6) receptor, approved for the treatment of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA). This article is protected by copyright. All rights reserved.
January 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29283463/neck-rejuvenation-by-direct-anterior-medial-cervicoplasty-the-modified-zigzag-plasty-according-to-tschopp
#9
Alexander Konstantinow, Tatjana Fischer, Alexander Zink
BACKGROUND: Conventional cervicofacial rhytidectomy has become the standard treatment of skin excess of the ageing neck. However, some patients want to avoid an extensive surgical procedure, especially if the anterior neck is the predominant problem zone. OBJECTIVE: To report on the efficacy and safety of a zigzag-shaped skin excision combined with platysma plication. METHODS & MATERIALS: We present a retrospective case review series of 6 female patients...
December 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29283462/role-of-t-helper-17-cells-and-t-regulatory-cells-in-alopecia-areata-comparison-of-lesion-and-serum-cytokine-between-controls-and-patients
#10
Seung-Hee Loh, Hae-Na Moon, Bark-Lynn Lew, Woo-Young Sim
BACKGROUND: Alopecia areata (AA) is an organ-specific autoimmune disease with T-cell-mediated attack of hair follicle autoantigens. As T-helper 17 (Th17) cells and T regulatory (Treg) cells are crucially involved in the pathogenesis, the role of Th17 and Treg cytokines has not been studied yet. OBJECTIVE: To determine whether AA is associated with alterations in lesional and serum Th17 and Treg cytokines, and studied whether they were associated with clinical type...
December 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29283460/a-novel-scale-for-measurement-of-acquired-dermal-macular-hyperpigmentation-adhm-severity
#11
Keshavamurthy Vinay, Garima Dabas, Davinder Parsad, Sendhil Kumaran Muthu
Acquired dermal macular hyperpigmentation (ADMH) is a hypernym which includes lichen planus pigmentosus (LPP), Riehl's melanosis (RM), pigmented contact dermatitis (PCD) and erythema dyschromicum perstans (EDP). There is considerable overlap between the clinical and histopathological features of these conditions. Despite affecting a large number of patients, there is no validated quantitative scale for LPP/EDP/RM/PCD/ADMH. This article is protected by copyright. All rights reserved.
December 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29283454/design-development-and-optimization-of-a-transungual-duple-nail-lacquer-for-onychomycosis-therapy
#12
Nazia Hasan, Manvi Singh, Sufiyanu Sulaiman, Shyamasree Nandy, Mridu Dudeja, Asgar Ali, Zeenat Iqbal
Onychomycosis is a degenerative fungal infection inflicting toes and finger nails which is caused by both dermatophytes and non-dermatophytes such as Trichophyton rubrum and Candida spp. respectively. The infection apparently causes nail mutilation making nails stiff, skinny, flawed, and dyschromic. Owing to the anatomical presentation of the disease, a topical application is warranted which asserts positive attributes like ease of preparation, improved adherence, negligible drug interactions, low systemic adverse effects and voluntary removal...
December 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29283443/letter-on-european-dermatology-forum-s1-guideline-on-the-diagnosis-and-treatment-of-sclerosing-diseases-of-the-skin-part-2-scleromyxedema-scleredema-and-nephrogenic-systemic-fibrosis
#13
Patrick Mark, Ilona Dekkers, Peter Blankestijn, Tim Leiner, Giles Roditi
We read with interest the guidelines recently published on sclerosing diseases of the skin (Part 2: Scleromyxedema, scleredema and nephrogenic systemic fibrosis)[1, 2]. However, we are concerned that the guideline recommendations proposed for prevention of nephrogenic systemic fibrosis (NSF) are potentially dangerous. Although we recognise the challenges in constructing comprehensive guidelines, we are concerned that this may be because the guidelines have not involved a multidisciplinary team. This article is protected by copyright...
December 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29265550/inter-rater-and-intra-rater-agreement-of-confocal-microscopy-imaging-in-diagnosing-and-subtyping-basal-cell-carcinoma
#14
D J Kadouch, A van Haersma de With, Y S Elshot, M Peppelman, M W Bekkenk, A Wolkerstorfer, I Eekhout, C A C Prinsen, M A de Rie
BACKGROUND: Reflectance confocal microscopy (RCM) imaging can be used to diagnose and subtype basal cell carcinoma (BCC) but relies on individual morphologic pattern recognition that might vary among users. OBJECTIVES: We assessed the inter-rater and intra-rater agreement of RCM in correctly diagnosing and subtyping BCC. METHODS: In this prospective study we evaluated the inter-rater and intra-rater agreement of RCM on BCC presence and subtype among three raters with varying experience who independently assessed static images of 48 RCM cases twice with four weeks interval (T1 and T2)...
December 19, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29265517/two-novel-mutations-in-the-tsc2-gene-causing-severe-phenotype-in-nervous-system-and-skin-in-a-patient-with-tuberous-sclerosis-complex
#15
F Cammarata-Scalisi, C Vidales Moreno, F Stock, A Avendaño, D Araque, M A Lacruz-Rengel, A Diociaiuti, E Bellacchio, M Callea
Tuberous sclerosis complex (TSC1, OMIM 191100 and TSC2 OMIM 613254) is an autosomal dominant neurocutaneous disorder that affects multiple organs, associated with the development of wide spread hamartomatous lesions including brain, eyes, lungs, heart, liver, kidneys and skin. Mutations in the tumor suppressor genes, TSC1 at 9q34 and TSC2 at 16p13.3, which encode the proteins hamartin and tuberin respectively, detected in approximately 85-90% of the cases. The majority of cases occur sporadically, with a family history found in only 30% of patients...
December 19, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29265512/the-inhibitor-of-apoptosis-protein-livin-is-upregulated-in%C3%A2-psoriasis-vulgaris
#16
Hao Wang, Liwei Ran, Ke Hui, Xinqi Pei, Xinyang Wang, Yan Zheng
Psoriasis vulgaris (PV) is widely considered as a chronic inflammatory skin disease which is characterized hyperplasia with incomplete differentiation and decreased apoptosis of epidermal keratinocytes(1). The patients with PV suffer severe physical and psychological discomfort, and often have decreased life quality. However, traditional treatments of PV cannot meet the needs of patients(2). So it is crucial and urgent to explore the underlying molecular mechanism of PV and develop new target therapy to PV...
December 19, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29265508/the-investigated-question-and-study-design-in-cross-sectional-studies-response-to-chronic-urticaria-and-the-metabolic-syndrome-a-cross-sectional-community-based-study-of-11-261-patients-authors-reply
#17
G Shalom, J Dreiher, S Tiosano, A D Cohen
We read with interest the letter by Soria et al. We have been studying Chronic Urticaria (CU) for several years. During this time, we have evaluated the disease and associated conditions from several aspects. The study presented by Soria et al. compared the severity of CU between a small group of obese CU patients and another small group of non-obese CU patients, all recruited in inpatient clinics of a hospital setting. This article is protected by copyright. All rights reserved.
December 19, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29265498/reply-to-chronic-urticaria-and-the-metabolic-syndrome-a-cross-sectional-community-based-study-of-11-261-patients
#18
Angèle Soria, Aurélie Du-Thanh, Emmanuelle Amsler, Nadia Raison-Peyron, Pascale Mathelier-Fusade, Delphine Staumont-Sallé, Florence Hacard, Isabelle Boccon-Gibod, Emeline Castela, Pauline Pralong, Doutre Marie-Sylvie, Etienne Puymirat
We recently read with interest the article by Shalom et al. (1), which reported in multivariate analysis, an association between chronic urticaria (CU) and metabolic syndrome (MS) in a cross-sectional community-based study of 11261 patients with chronic urticaria (CU) compared to control (odd ratio: 1.12 95% CI: 1.05-1.21, p=0.001). With this regard, we would like to make several comments. This article is protected by copyright. All rights reserved.
December 19, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29265481/somatostatin-receptor-type-2-expression-in-merkel-cell-carcinoma-as-a-prognostic-factor
#19
K V Orlova, V V Delektorskaya, Y V Vishnevskaya, T T Kondratieva, N F Orel, A A Markovich, L V Demidov, S Subramanian
Merkel cell carcinoma (MCC) is a rare, aggressive, polyomavirus associated tumor with neuroendocrine and epithelial differentiation. The status of somatostatin receptors (SSTRs) are well characterized in neuroendocrine tumors [1, 2]. The levels of expression of SSTRs differ considerably in different tumors, immunohistochemistry (IHC) to identify the features of their key parameters allow us to assign a reasonable therapy with somatostatin analogues. The cases of successful treatment and diagnostics of metastatic MCC using radiolabelled somatostatin analogues [3, 4, 5] described in the literature...
December 19, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29265421/hidradenitis-suppurativa-treated-with-wide-excision-and-second-intention-healing-a-meaningful-local-cure-rate-after-253-procedures
#20
Inge E Deckers, Yalda Dahi, Hessel H van der Zee, Errol P Prens
BACKGROUND: Surgery is an important treatment modality for hidradenitis suppurativa (HS). Various methods of HS surgery have been described. Even though wide excision is a common surgical procedure for HS, data on the recurrence rate and patient satisfaction are scarce. OBJECTIVE: To determine the recurrence rate and patient satisfaction of HS lesional wide excision (complete excision) with secondary intention healing. METHODS: A single center retrospective study...
December 19, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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