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Journal of the European Academy of Dermatology and Venereology: JEADV

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https://www.readbyqxmd.com/read/28107605/creating-immunocompromised-districts
#1
K Ramey, J Ibrahim, R T Brodell
We read the letter to the editor, Viral warts and seborrheic keratosis on tattoos: a review of 9 cases with great interest.(1) Dermatologists see only what they know! Once we recognized the possibility that warts might grow preferentially in black and blue tattoo dye, we collected 7 cases over a 10-year period from one solo private practice. In this report, a patient with a pre-existing viral wart on skin adjacent to a new tattoo appears to have preferentially spread onto the immunocompromised district (Ruocco, 2009)(2) created by black ink nanoparticles...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28107597/viral-warts-and-seborrheic-keratoses-on-tattoos-a-review-of-9-cases
#2
Nicolas Kluger
We wish to add to the recent article by Ramley et al(1) our experience on 8 cases of viral warts and one case of seborrheic keratosis (SK) on tattoos. Those cases were collected with the help of dermatologists and family doctors between 2007 and 2016. We reviewed the demographic data, delay of onset after tattooing, clinical presentation and outcomes whenever possible. The number of lesions was counted manually from the available pictures. This article is protected by copyright. All rights reserved.
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28107593/patient-satisfaction-in-dermatology
#3
Emilie Brenaut, Claire-Alice De Salins, Laurent Misery, Anne-Marie Roguedas-Contios
We are pleased that there is a growing interest from doctors in patient'satisfaction. According to PubMed data and the key words 'patient' AND 'satisfaction', we found an impressive increase of the number of articles, from 179 in 1985 to 7,211 in 2015. We were highly interested by the lecture of the letter « Patient satisfaction and the waiting room in Mohs surgery: appropriate pre-warning may abrogate boredorm » from F.R. Ali, F. Al-Niaimi, E.E. Craythorne, R. Patalay and R. Mallipeddi and thank them for their interest in our paper...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28107592/psoriasis-and-palmoplantar-pustulosis-an-endless-debate
#4
Alexandra Maria Giovanna Brunasso, Cesare Massone
Since 2007, palmoplantar pustulosis (PPP) has been classified as a separate entity and not a clinical variant of psoriasis despite the presence of certain phenotypes common in both diseases.(1) We read with interest the review by Misiak-Galazka et al., and we found that even after the extensive work (inclusion of 65 articles), some relevant data are missing.(1-3) The clue question remains the following: Is palmoplantar pustulosis (PPP) closely related to psoriasis or is PPP a separate condition? Herein we will systematically review the literature searching for frequency of psoriasis in PPP patients and we will discuss new genetic insights that connect PPP and psoriasis vulgaris...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28107579/experience-of-skin-cancer-and-contact-with-health-professionals-is-associated-with-increased-skin-cancer-knowledge-but-not-sun-safety-knowledge-or-behaviour
#5
Charlotte L Thomas, Pablo Fernández Peñas
The mortality and morbidity associated with melanoma is unquestionable, but its global incidence is greatly outnumbered by that of non-melanoma skin cancer (NMSC). The economic burden of NMSC is significant, falling within the US' top five most costly cancers (1) . In Australia, a high level of skin cancer awareness has been reported (2) . Public health campaigns and advice provided by individual health professionals seek to increase knowledge about skin cancer, risk factors and protective sun-safety behaviours...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28107578/patient-satisfaction-and-the-waiting-room-in-mohs-surgery-appropriate-pre-warning-may-abrogate-boredom
#6
F R Ali, F Al-Niaimi, E E Craythorne, R Patalay, R Mallipeddi
Patient satisfaction in dermatology consultations has rightly been afforded attention by De Salins and colleagues.(1) When considering the patient journey through an outpatient appointment, a significant proportion of time is spent in the waiting room, a period which is poorly understood and may contribute to patient anxiety and perceived satisfaction with treatment.(2) In our outpatient Mohs micrographic surgery (MMS) unit, patients may be waiting for several hours in total whilst histological specimens are processed and analysed, prior to reconstruction, particularly if multiple MMS stages are needed...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28107577/is-palmoplantar-pustulosis-simply-a-variant-of-psoriasis-or-a-distinct-entity
#7
Magdalena Misiak-Galazka, Hanna Wolska, Lidia Rudnicka
We read with interest the comment of Brunasso and Massone to our review article.(1) We agree that palmoplantar pustulosis (PPP) shares many features with palmoplantar pustular psoriasis (PPPP), and about 1/3 patients with PPP present with psoriasis lesions (skin, nail or joint changes). The close relationship and coexistence of PPP and psoriasis was confirmed in many studies. (3-5) This article is protected by copyright. All rights reserved.
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28107576/non-invasive-anaesthetic-methods-for-dermatological-laser-procedures-a-systematic-review
#8
REVIEW
K Greveling, E P Prens, L Liu, M B A van Doorn
Pain is a common side-effect of dermatological laser procedures. Non-invasive anaesthetic drugs and anaesthetic procedures can be used to provide pain relief and increase patient satisfaction and treatment efficacy. However, it remains unclear which method provides the best pain relief. The objective of this systematic review was therefore to assess the efficacy and safety of non-invasive anaesthetic methods during dermatological laser procedures. A systematic literature search was conducted. Randomized and non-randomized controlled clinical trials (RCTs and CCTs) were included...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28107575/spanish-version-of-actinic-keratosis-quality-of-life-questionnaire-akqol
#9
I Alarcon, G R Vinding, K B Christensen, S Esmann, J Malvehy, S Puig, G B E Jemec
BACKGROUND: Patient Reported Outcome Measures are very important outcomes. For specific diseases Health Related Quality of Life-instruments (HRQoL) are increasingly used to provide data on patients' overall perceptions of the course of a given disease. Actinic keratoses (AKs) are common keratotic lesions that occur on chronically sunlight-exposed skin. Only few studies regarding HRQoL in AKs have been made. OBJECTIVE: In order to be able to compare HRQoL among different countries and cultures we aimed to translate and validate the Actinic Keratosis Quality of Life (AKQoL) questionnaire into Spanish and quantify the impairment caused by AKs in Spanish patients...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28107570/efficacy-and-safety-of-interleukin-17-antagonists-in-patients-with-plaque-psoriasis-a-meta-analysis-from-phase-3-randomized-controlled-trails
#10
Dan Wu, Si-Yuan Hou, Shuai Zhao, Lin-Xin Hou, Ting Jiao, Nan-Nan Xu, Ning Zhang
BACKGROUND: The interleukin-17 (IL-17) cytokine pathway plays a key role in the development of psoriasis. Antibodies targeting IL-17 or blocking its receptor may be a new therapeutic approach for psoriasis. To assist treatment selection in daily practice it is essential to understand the benefit and risk profile of IL-17 antagonists. OBJECTIVE: We performed a meta-analysis to evaluate the efficacy and safety of IL-17 antagonists in patients with psoriasis. METHODS: We searched a number of databases for relevant randomized clinical trials (RCTs) published before May 2016...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28107565/idermatopath-a-novel-software-tool-for-mitosis-detection-in-h-e-stained-tissue-sections-of-malignant-melanoma
#11
C Andres, B Andres-Belloni, R Hein, T Biedermann, A Schäpe, N Brieu, R Schönmeyer, M Yigitsoy, J Ring, G Schmidt, N Harder
BACKGROUND: Malignant Melanoma (MM) is characterized by a growing incidence and a high malignant potential. Beside well defined prognostic factors such as tumor thickness and ulceration, the Mitotic Rate (MR) was included in the AJCC recommendations for diagnosis and treatment of MM. In daily routine, the identification of a single mitosis can be difficult on Hematoxylin&Eosin slides alone. Several studies showed a big inter- and intra-individual variability in detecting the MR in MM even by very experienced investigators, thus raising the question for a computer assisted method...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28107564/tattoo-removal-by-q-switched-yag-laser-client-satisfaction
#12
K Hutton Carlsen, J Esmann, J Serup
BACKGROUND: Tattoo removal by Q-switched lasers is golden standard; however, clients' satisfaction with treatment is little known. OBJECTIVE: To determine clients' satisfaction with tattoo removal. METHODS: 154 tattoo removal clients who had attended the private clinic "Centre for Laser Surgery", Hellerup, Denmark from 2001-2013 completed a questionnaire concerning outcome expectations, level of pain experiences and satisfaction with tattoo removal...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28107559/a-randomized-double-blind-placebo-controlled-dose-escalation-first-in-man-study-phase-0-to-assess-the-safety-and-efficacy-of-topical-cytosolic-phospholipase-a2-inhibitor-avx001-in-patients-with-mild-to-moderate-plaque-psoriasis
#13
S H Omland, A Habicht, P Damsbo, J Wilms, B Johansen, R Gniadecki
BACKGROUND: Cytosolic Phospholipase A2 (cPLA2α) is an enzyme suggested as a therapeutic target in inflammatory skin diseases. AVX001, a cPLA2α-inhibitor was investigated in a randomized, double-blind, placebo-controlled, split-design, first-in-man study in patients with mild to moderate psoriasis. OBJECTIVES: The primary objective was to evaluate cutaneous safety and tolerability of AVX001 in doses from 0.002%-5.0%. Safety was assessed as local skin reaction adverse events (LSRAE) grade 3-4...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28079942/treatment-of-capillary-malformation-using-topical-timolol-combined-with-585-nm-pulsed-dye-laser-a-prospective-randomized-split-lesion-study
#14
Sang-Jin Cheon, Woo-Haing Shim, Gun-Wook Kim, Hoon-Soo Kim, Byung-Soo Kim, Moon-Bum Kim, Hyun-Chang Ko
Capillary malformation (CM) is a congenital vascular malformation characterized by the dilation of superficial dermal blood vessels.(1)  Currently, pulsed dye laser (PDL) is considered the gold standard for the treatment of CM.(1)  However, its use results in incomplete clearance despite multiple sessions and relapses during long-term follow-up.(1)  Alternative methods are needed to achieve improved therapeutic results. This article is protected by copyright. All rights reserved.
January 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28079929/the-impact-of-age-on-psoriasis-health-care-in-germany
#15
A Trettel, C Spehr, A Körber, M Augustin
INTRODUCTION: Inequality between age groups has been demonstrated in the prescription of biologics, yet systematic real-world data about age-related differences in psoriasis care are missing. OBJECTIVE: To investigate disparities in psoriasis characteristics by age groups and to identify potential impact on psoriasis health care. PATIENTS AND METHODS: Data analysis included 3,615 patients from the German Psoriasis registry PsoBest, which observes adult patients with moderate to severe psoriasis or psoriatic arthritis (PsA) on systemic treatment over a time period of 10 years...
January 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28079925/pregnancy-outcome-after-rituximab-treatment-before-conception-in-patients-affected-by-severe-pemphigus-vulgaris-superficialis
#16
C Vassallo, S Grassi, E Tagliabue, A Piccolo, V Brazzelli
Pregnancy is rare among patients affected by pemphigus, especially in European countries, mainly because of older patients, lower fertility rates and possible teratogenic risk.(1) Avoidance of immunosuppressive medications during pregnancy has been recommended, but inadequate treatment of pemphigus may increase morbidity and mortality.(2) Corticosteroids remain the first-line agent for treatment of pemphigus in pregnancy when low dosages are sufficient for disease control; however, prednisone and its metabolites crosses the placenta barrier, and high levels in the serum have been associated with adverse fetal outcomes...
January 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28079922/iga-tracheobronchial-deposits-underlie-respiratory-compromise-in-neonatal-linear-iga-bullous-dermatosis
#17
A Diociaiuti, G Zambruno, F Diomedi Camassei, G Di Zenzo, I Capolupo, F Stoppa, V Forziati, M El Hachem
The childhood variant of linear IgA bullous dermatosis (LABD) is characterized by blistering lesions of the perineum and perioral area with an annular or "rosette-like" arrangement, in addition to the pathognomonic linear IgA deposits along the cutaneous basement membrane zone (BMZ).(1) The disease mainly occurs in preschool children.(1) However, a handful of neonatal cases have been described, most of them presenting with severe mucosal involvement.(2-8) We report an additional case of neonatal LABD with life-threatening respiratory tract manifestations...
January 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28079921/four-cases-of-exogenous-acral-pigmentation-related-to-a-darkeling-beetle-coleoptera-tenebrionidae-blaps
#18
S Mokni, L Boussofara, W Saidi, A Aounallah, C Belajouza, N Ghariani, R Nouira, M Denguezli
Beetle (coleoptera) is the largest insect order colonizing all continents 1-2. Most of the beetles synthesize hemolymph containing several chemicals used as signals or defensive secretions against predators 2. Coleoptera body fluids can accidentally come into contact with humans' skin and induce dermatitis. Skin contact with the beetles commonly causes blistering skin eruption 3. This article is protected by copyright. All rights reserved.
January 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28079920/serum-microrna-profiles-in-patients-with-syphilis
#19
Ping Lu, Chang Fang, Qing Cheng, Wu-Jian Ke, Tao Huang, Jun Zhang, He-Ping Zheng, Bin Yang
Syphilis is an acute and chronic inflammatory disorder caused by the non-cultivatable spirochete Treponema pallidum subsp. pallidum (T. pallidum).(1,2) T. pallidum does not produce any known toxic proteins; therefore, most of the symptoms and tissue damage related to syphilis are caused by activation of the host's inflammatory and immune responses,(3) thus suggesting that host genetics play an important role in regulating the progression of syphilis infection. MiRNAs are a class of 19- to 24-nt noncoding RNAs that influence many biological systems, including development, cellular differentiation, proliferation, apoptosis, metabolism, and the immune response;(4-6) they also play crucial roles during microbial infection...
January 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28052464/thymoma-associated-multi-organ-autoimmunity-two-cases-and-a-review-of-the-literature
#20
K Shiba, Y Fujita, H Miyazawa, K Muramatsu, M Watanabe, M Nishimura, S Shinkuma, T Nomura, W Nishie, J Taguchi, I Kinoshita, H Shimizu
Thymoma-associated multi-organ autoimmunity (TAMA) is defined as a disease of the liver, intestine, and skin, which histopathologically resembles graft-versus-host disease (GVHD).(1,2) Several sporadic cases imply that cutaneous manifestations of TAMA are associated with a poor prognosis.(2-5) However, it is difficult to examine the association because of the rarity of the disease. Herein we describe two cases of TAMA with cutaneous lesions and fatal courses, and review the literature with a focus on the prognosis...
January 3, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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