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Journal of the European Academy of Dermatology and Venereology: JEADV

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https://www.readbyqxmd.com/read/30223310/type-iv-allergy-to-antimalarials-can-mimic-cutaneous-manifestations-of-lupus-erythematosus
#1
Liliane Borik, Peter Petzelbauer, Tamara Quint, Stefan Wöhrl, Tamar Kinaciyan, Peter Maximilian Heil
The antimalarials chloroquine and hydroxychloroquine are key medications in the long-term therapy of systemic and cutaneous lupus erythematosus, a disease characterized by a plethora of potential cutaneous manifestations. Reports on the frequency and type of dermatologic side effects of antimalarials are sparse and heterogenous, ranging from 0.1% to more than 10% of treated patients and including the very general term "cutaneous eruption" as well as dyspigmentation, alopecia, hair bleaching, pruritus, polymorphous light eruption, Stevens-Johnson syndrome and toxic epidermal necrolysis...
September 17, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30223307/screening-for-syphilis-with-dual-algorithms-analysis-of-discordant-and-concordant-serology-results-in-a-population-with-a-low-prevalence-of-syphilis
#2
Yi-Hui Zhuang, Hua Liu, Jin Tang, Ying-Zhi Wang, Xiao-Hong Zheng, Yan Gong, Xiao-Feng Xu, Xiang Gao, Ren-Quan Lu, Song-Guang Ju, Lin Guo
BACKGROUND: Currently, many laboratories have switched the traditional screening algorithm (TSA) to reverse screening algorithm (RSA) for the efficiencies in high-volume syphilis screening. However, confusions have been arisen regarding this paradigm shift. OBJECTIVE: To compare the performance of two algorithms with head-to-head mode. METHODS: Sera screening for syphilis were tested in parallel with chemiluminescence immunoassay (CIA) and toluidine red unheated serum test (TRUST)...
September 17, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30223303/morphological-classification-system-of-hair-regrowth-patterns-in-alopecia-areata-patches-dimt-classification
#3
H Lee, S Lee, W S Lee
Alopecia areata (AA) is an autoimmune disease causing non-scarring hair loss. In many cases, regrowth of hair can be expected either with or without treatment. In vitiligo, which has similarities in pathogenesis with AA, repigmentation patterns have been classified into 5 distinct patterns: diffuse, marginal, perifollicular, combined, and medium-spotted. This article is protected by copyright. All rights reserved.
September 17, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30223293/p-ventricosus-detection-in-a-baby-skin-folds
#4
Linda Tognetti, Elisa Cinotti, Pietro Rubegni
A 20-month-old healthy baby was referred during the summertime for a 15 and 20 days-history of two erythematous scaling patches of the axillar (fig.1a) and popliteal (fig.1b) folds, respectively, slightly itching at onset. The clinical history was mute except for contacts with cats in the last months and anti-Meningococcal vaccination one month before, followed by fever and transient erythema of the chest. This article is protected by copyright. All rights reserved.
September 17, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30199578/successful-treatment-of-metastatic-mucosal-melanoma-with-a-del579-c-kit-mutation-by-imatinib-after-treatment-of-anti-pd-1-antibody
#5
Chisato Yamashita, Atsushi Otsuka, Motoo Nomura, Tetsuya Honda, Kenji Kabashima
C-KIT mutations and amplifications are seen in approximately 15 to 30% of acral and mucosal melanomas. As c-KIT is a validated therapeutic target in other cancers, such as gastrointestinal stromal tumor (GIST) and chronic myelogenous leukemia (CML), there are several reports of melanoma patients with c-KIT mutation achieving good response to the off-label use of multi-tyrosine kinase inhibitors such as imatinib. The improved efficacy of sequential treatment with immunotherapies including programmed cell death1 (PD-1) blockade is currently being investigated...
September 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30198598/clinical-outcomes-in-patients-on-secukinumab-cosentyx-%C3%A2-within-a-specialist-psoriasis-clinic-a-single-centre-retrospective-cohort-study
#6
A V Sears, C Szlumper, K W Liu, C H Smith, J N W N Barker, A E Pink
Secukinumab, a fully human anti-IL-17A monoclonal antibody, is a highly effective therapy for chronic plaque psoriasis. Up to 81.6% of patients achieved ∆PASI75 responses after 12 weeks in trials1-3 . However, up to 30% of patients on systemic therapy for psoriasis would be ineligible to participate in such trials4,5 . The aim of this retrospective observational study was to assess the real-world clinical effectiveness of secukinumab in patients attending our specialist psoriasis clinic. This article is protected by copyright...
September 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30198596/successful-treatment-of-resistant-condylomas-with-nitrizinc-complex-solution-a-retrospective-study-in-11-patients
#7
Awatef Kelati, Abdallah Khemis, Henri Montaudié, Jean-Philippe Lacour, Thierry Passeron
Ano-genital warts (AGW) are benign epithelial skin lesions caused by human papilloma virus (HPV) subtypes 6 and 11(1). AGW are frequently a cause a discomfort and a psychological outweighs. Unfortunately, the treatment remains challenging(2-3). Nitrizinc complex (NZC) solution is a complex of organic acids, nitric acid in addition to zinc and copper salts which produces a painless mummification of the damaged tissue. NCZ has shown its efficacy in difficult-to-treat extragenital warts(4, 5). The objective of this study was to investigate the efficacy and tolerance of NZC for treating resistant AGW...
September 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30198589/diagnostic-accuracy-of-a-new-ex-vivo-confocal-laser-scanning-microscope-clsm-compared-to-h-e-stained-paraffin-slides-for-micrographic-surgery-of-basal-cell-carcinoma
#8
Nina Peters, Melanie Schubert, Gisela Metzler, Jan-Philipp Geppert, Matthias Moehrle
BACKGROUND: For safe excision of malignant skin tumours, complete negative surgical margins are mandatory. The gold standard for analysis is frozen sections or paraffin-embedded haematoxylin and eosin- (H&E)-stained slides. The production of H&E-stained slides is time-consuming (>20 hrs) while wounds remain unclosed. An upcoming method is confocal laser scanning microscopy (CLSM), a technique that scans unfixed fresh tissue rapidly. OBJECTIVE: Evaluation of the process to generate and analyse CLSM images and assessment of the accuracy to detect basal cell carcinoma (BCC) tissue...
September 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30198588/long-term-safety-profile-of-ixekizumab-in-patients-with-moderate-to-severe-plaque-psoriasis-an-integrated-analysis-from-11-clinical-trials
#9
R G Langley, A B Kimball, H Nakagawa, W Xu, B Pangallo, O O Osuntokun, N Agada, K Reich
BACKGROUND: Psoriasis in many patients is a chronic and recalcitrant disease that requires long-term treatment, reinforcing the importance of long-term safety data. Ixekizumab, a high-affinity monoclonal antibody that selectively targets interleukin (IL)-17A, is approved for treating patients with moderate-to-severe plaque psoriasis. OBJECTIVE: To determine long-term safety of ixekizumab in psoriasis. METHODS: Integrated safety data are presented from 12-week induction period, 12-60-week maintenance period, and from all ixekizumab-treated patients from 11 clinical studies...
September 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30198584/decreased-photosensitivity-to-uva-on-vemurafenib-combined-with-cobimetinib
#10
Cécile Frenard, Hervé Dutartre, Aurélie Boisrobert, Amir Khammari, Brigitte Dreno
Vemurafenib is a BRAF inhibitor used in the treatment of stage IV melanomas. One of the adverse events of this treatment is the induction of a photosensitivity. Dummer et al. and our team have previously shown that this photosensitivity was exclusively induced by UVA and defined by a minimum erythema dose (MED) of UVA of less than 20 joules, present in about 84% of patients and disappearing rapidly upon treatment discontinuation. This article is protected by copyright. All rights reserved.
September 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30198583/prevalence-and-risk-factors-of-dermatoporosis-a-prospective-observational-study-of-dermatology-outpatients-in-a-finnish-tertiary-care-hospital
#11
Nicolas Kluger, Sanna Impivaara
BACKGROUND: Dermatoporosis describes the cutaneous signs and complications related to chronic cutaneous fragility related to aging, chronic sun exposure and long-term use of topical and systemic corticosteroids. Chronic renal failure may be an additional co-factor. The prevalence of dermatoporosis is estimated around 32 to 37% in France among the elderly. OBJECTIVE: We evaluated the prevalence of dermatoporosis and its risk factors in outpatients who attended a consultation in the department of dermatology of Helsinki University Central Hospital...
September 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30198582/predictors-of-treatment-success-in-children-with-difficult-to-treat-atopic-dermatitis-using-a-personalized-integrative-multidisciplinary-treatment-program-pim
#12
K B Fieten, R Schappin, W T Zijlstra, L Rijssenbeek-Nouwens, Y Meijer, S G M A Pasmans
BACKGROUND: A 6 week personalized integrative multidisciplinary treatment program (PIM) was developed for children with difficult to treat AD who appeared unresponsive to treatment according to current guidelines. OBJECTIVE: The aim of the present study was to identify clinical and psychosocial characteristics that predict long-term treatment success after PIM. METHODS: Treatment was considered successful when there was a 75% reduction on the Self-Administered Eczema Area and Severity Index and/or little impact of AD on daily life, measured with the Children's Dermatology Life Quality Index (score <= 6), six months after the end of PIM...
September 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30193410/cross-european-validation-of-the-itchyqol-in-pruritic-dermatoses
#13
C Zeidler, S Steinke, C Riepe, P Bruland, I Soto-Rey, M Storck, S Garcovich, C Blome, S Bobko, F J Legat, N Potekaev, A Lvov, L Misery, W Weger, A Reich, E Şavk, M Streit, E Serra-Baldrich, J C Szepietowski, G Yosipovitch, S C Chen, M Dugas, S Ständer
BACKGROUND: Chronic pruritus (CP) is a frequently occurring symptom in inflammatory dermatoses, causing a high burden and limitations to health related quality of life (HRQoL). OBJECTIVE: The ItchyQoL was developed to assess the impairment to HRQoL in patients with CP. However, it has only been validated in English and German. Here we report the validation in several languages across Europe. METHODS: After professional translation, the versions of ItchyQoL were digitized for use as a tablet application...
September 7, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30176180/secukinumab-survival-and-long-term-efficacy-in-patients-with-plaque-psoriasis-real-life-data-from-a-tertiary-hospital-in-greece
#14
Elena Sotiriou, Aikaterini Tsentemeidou, Efstratios Vakirlis, Nikolaos Sideris, Demetrios Ioannides
Secukinumab is an anti-IL17A antibody approved for the treatment of moderate-to-severe plaque psoriasis since 2015.1 After 52 weeks of a 300 mg monthly dosage, 78.20-84.30% of patients maintained PASI75 in clinical trials. 1-3 Efficacy seems to be less well maintained in real life, however, as 60-74% and 53.80-78% of biologic naïve and non-naïve patients respectively, as well as 68.30-80% of patients regardless of prior treatment, had PASI75 at week 52.4-7 This article is protected by copyright. All rights reserved...
September 3, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30176179/management-of-patients-with-hereditary-angioedema-in-germany-comparison-to-other-countries-in-the-icatibant-outcome-survey
#15
M Maurer, K Bork, I Martinez-Saguer, E Aygören-Pürsün, J Botha, I Andresen, M Magerl
BACKGROUND: The Icatibant Outcome Survey (IOS; NCT01034969) is a Shire-sponsored, international, observational study monitoring the safety and effectiveness of icatibant, a bradykinin B2 receptor antagonist approved for the acute treatment of adults with hereditary angioedema with C1 inhibitor deficiency (HAE-C1-INH). OBJECTIVE: To report IOS data comparing demographic and icatibant-treatment outcomes in patients with HAE-C1-INH from Germany to HAE-C1-INH patients from 11 other IOS countries...
September 3, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30176169/survival-disease-progression-and-prognostic-factors-in-elderly-patients-with-mycosis-fungoides-and-s%C3%A3-zary-syndrome-a-retrospective-analysis-of-174-patients
#16
E Lebowitz, S Geller, E Flores, M Pulitzer, S Horwitz, A Moskowitz, M Kheterpal, P L Myskowski
BACKGROUND: Advanced age at diagnosis is considered a poor prognostic factor in mycosis fungoides (MF) and Sézary syndrome (SS). OBJECTIVE: To evaluate the outcomes and prognostic factors in patients diagnosed at an advanced age (>65 years) with MF/SS. METHODS: Survival, progression rates and various clinical and histopathological variables were studied in a group of 174 elderly patients diagnosed with MF/SS between 1992 and 2015 at a single referral cancer center in the United States...
September 3, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30176093/four-compartment-method-as-an-efficacious-and-simplified-technique-for-autologous-non-cultured-epidermal-cell-suspension-preparation-in-vitiligo-surgery-a-randomized-active-controlled-study
#17
Sahil Mrigpuri, Muhammed T Razmi, Sendhil Kumaran Muthu, Keshavamurthy Vinay, Niharika Srivastava, Davinder Parsad
BACKGROUND: Autologous non-cultured epidermal cell suspension (NCES) is a successful surgical method for repigmentation of stable, refractory vitiligo. The need for laboratory equipment and expertise restricts it to only a few research centers; hence there is requisite to simplify the technique of NCES preparation. OBJECTIVES: To evaluate the efficacy of NCES prepared by four-compartment (4C) method compared to the laboratory-based method (lab-NCES). METHODS: Anatomically based matched lesions (41 pairs) in 30 stable vitiligo patients were randomized to receive NCES prepared by 4C method or lab-NCES...
September 3, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30176092/comparison-of-clinical-and-ultrasound-scores-in-patients-with-hidradenitis-suppurativa-results-from-an-italian-ultrasound-working-group
#18
M Napolitano, P G Calzavara-Pinton, A Zanca, L Bianchi, R D Caposiena Caro, A M Offidani, G Ganzetti, E Molinelli, V Dini, T Oranges, M Romanelli, C G Egan, G Fabbrocini, G Monfrecola, F Lacarrubba, M L Musumeci, E Passoni, M Venturini, G Micali
Hidradenitis suppurativa (HS), is a chronic inflammatory disease affecting the skin-bearing terminal of hair follicles and apocrine glands whose diagnosis and staging are clinical1,2 . Scores mainly rely on physical findings and although easily performed, lack information on disease severity. Ultrasound (US) aids in the diagnosis and assessment of HS disease severity3 . This article is protected by copyright. All rights reserved.
September 3, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30176066/hidradenitis-suppurativa-acne-inversa-a-practical-framework-for-treatment-optimization-systematic-review-and-recommendations-from-the-hs-alliance-working-group
#19
REVIEW
C C Zouboulis, F G Bechara, J L Dickinson-Blok, W Gulliver, B Horváth, R Hughes, A B Kimball, B Kirby, A Martorell, M Podda, E P Prens, H C Ring, T Tzellos, H H van der Zee, K R van Straalen, A R J V Vossen, G B E Jemec
Hidradenitis suppurativa (HS)/acne inversa is a debilitating chronic disease that remains poorly understood and difficult to manage. Clinical practice is variable and there is a need for international, evidence-based and easily applicable consensus on HS management. We report here the findings of a systematic literature review, which were subsequently used as a basis for the development of international consensus recommendations for the management of patients with HS. A systematic literature review was performed for each of nine clinical questions in HS (defined by an expert steering committee), covering comorbidity assessment, therapy (medical, surgical and combinations), and response to treatment...
September 3, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30169916/investigation-of-the-predisposing-factor-of-pemphigus-and-its-clinical-subtype-through-a-genome-wide-association-and-next-generation-sequence-analysis
#20
Y Sun, H Liu, B Yang, C Wang, J N Foo, F Bao, A Irwanto, G Yu, X Fu, Z Wang, J You, J Liu, G Zhou, J Liu, F Zhang
BACKGROUND: Pemphigus is an autoimmune blistering disease with pemphigus vulgaris (PV) and foliaceus (PF) as the two major histological subtypes. Associations with HLA molecules have been suggested, but specific HLA risk variants as well as non-HLA risk variants remain to be discovered. METHODS: We performed a two-stage genome-wide association study in the Chinese Han population through a genome-wide discovery analysis and follow-up validation analysis in a total number of 210 PV, 159 PF and 2493 healthy controls...
August 31, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
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