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Journal of AOAC International

Naeemullah Khan, Mustafa Tuzen, Tasneem Gul Kazi
An innovative, rapid, and simple dual-dispersive liquidߛliquid microextraction (DDLL-ME) approach was used to extract uranium from real samples for the first time. The main objective of this study was to disperse extraction solvent by using an air-agitated syringe system to overcome matrix effects and avoid dispersion of hazardous dispersive organic solvents by using heat. The DDLL-ME method consisted of two dispersive liquidߛrliquid extraction steps with chloroform as the extracting solvent. Uranium formed complexes with 4-(2-thiazolylazo) resorcinol in the aqueous phase and was extracted in extracting solvent (chloroform) after the first dispersive liquidߛrliquid process...
May 25, 2017: Journal of AOAC International
Urška Kropf, Vekoslava Stibilj, Radojko Jaćimović, Jasna Bertoncelj, Terezija Golob, Mojca Korošec
The botanical origin of seven types of Slovenian honey was investigated by analysis of their elemental content using k0-instrumental neutron activation analysis. A total of 28 representative samples were collected from beekeepers all over Slovenia in 2 consecutive years. Nineteen of the 37 elements measured were present in amounts above their LOD. The present study suggests that the determination of only alkali elements might be sufficient for the classification of Slovenian honeys according to their botanical origin...
May 23, 2017: Journal of AOAC International
Milica Jovetić, Jelena Trifković, Dalibor Stanković, Dragan Manojlović, Dušanka Milojković-Opsenica
The present work aims to provide a contribution to the overall investigation of European unifloral honeys with regard to authentication according to botanical and geographical origins. The mineral content of 206 monofloral honey samples of five botanical origins from six different regions in Serbia was investigated by inductively coupled plasma optical emission spectrometry. Chemometric techniques were applied for the classification and differentiation of acacia, sunflower, and linden honey according to botanical origin, as well as acacia honey samples according to regional origin...
May 23, 2017: Journal of AOAC International
Shan Xiong, Zhipeng Deng, Peilu Sun, Yanling Mu, Mingxing Xue
<p>Osimertinib is a new-generation epidermal growth factor inhibitor for the treatment of non-small cell lung cancer. In the present study, a rapid and sensitive LC with tandem MS method was developed and validated for the determination of osimertinib in rat plasma. Chromatographic separation was carried out on a C18 column using acetonitrile and water containing 0.1% formic acid. The assay was validated over a concentration range of 1.0–1000 ng/mL for osimertinib, with a lower LOQ of 1.0 ng/mL...
May 22, 2017: Journal of AOAC International
Xian-Fei Zhang, Jun-Li Yang, Juan Chen, Yan-Ping Shi
<p>An herbal formula, Huang-Qi-Liu-Yi Tang, is a prescription medicine that has been commonly used for the treatment of prostatitis and condyloma acuminatum over the last thousand years. In this study, response surface methodology, with a Box–Behnken design (BBD), was used to optimize the decoction conditions of an herbal formula. Astragaloside, calycosin-7-glucoside, glycyrrhizic acid, liquiritin, polysaccharide, and extractum were used as multiple evaluation markers. Soak time, water-to-medicinal herb ratio, and extraction time were determined as the three main variables by single-factor experiments and further optimized to obtain the maximum yields for the six marker compounds...
May 22, 2017: Journal of AOAC International
Stig Valdersnes, Anita Birkenes, Livar Froyland
<p>The aim of this study was to develop and validate a method for the determination of balenine/ophidine (hereafter referred to as “balenine”) in whale extracts and muscle samples from Balaenoptera acutorostrata. Further, the goal was to evaluate the method's applicability for the determination of other histidine-containing dipeptides (HCDs): anserine and carnosine and their amino acids π-methylhistidine, τ-methylhistidine, histidine, and β-alanine. For balenine, the LOD and LOQ were found to be 0...
May 22, 2017: Journal of AOAC International
Uroš M Gašić, Dušanka M Milojković-Opsenica, Živoslav Lj Tešić
In recent years, the botanical and geographical origin of food has become an important topic in the context of food quality and safety, as well as consumer protection, in accordance with international standards. Finding chemical markers, especially phytochemicals, characteristic for some kind of food is the subject of interest of a significant number of researchers in the world. This paper is focused on the use of polyphenols as potential markers for the determination of botanical origin of honey. It includes a review of the polyphenols present in various honey samples and the methods for their separation and identification...
May 19, 2017: Journal of AOAC International
Jelena Trifković, Filip Andrić, Petar Ristivojević, Etil Guzelmeric, Erdem Yesilada
Honey is a precious natural product that is marketed with a wide range of nutritional and medicinal properties. However, it is also a product subjected to frequent adulteration through mislabeling and mixing with cheaper and lower-quality honeys and various sugar syrups. In that sense, honey authentication regarding its genuine botanical and geographical origins, as well as the detection of any adulteration, is essential in order to protect consumer health and to avoid competition that could create a destabilized market...
May 19, 2017: Journal of AOAC International
Kristina B Lazarević, Milica S Jovetić, Živoslav Lj Tešić
Honey is a complex mixture of various substances, and its composition depends on both botanical and geographical origin, as well as anthropogenic factors. The accurate identification of honey origin guarantees the satisfaction of consumers' needs and has an impact on the honey market value. Physicochemical parameters, some of which are used in routine analysis of honey quality, could be useful for the assessment of its origin. In this review, special attention is paid to those studies that assessed the sugar and mineral composition of honey, whether they were investigated in terms of botanical or geographical origin, or for the characterization of honey type...
May 19, 2017: Journal of AOAC International
Dušanka M Milojković-Opsenica, Živoslav Lj Tešić
No abstract text is available yet for this article.
May 19, 2017: Journal of AOAC International
Robyn M Lucas, Shelley Gorman, Lucinda Black, Rachel E Neale
There is widespread concern about the high prevalence of vitamin D deficiency amid evidence to support that such a state may increase the risk of a wide range of adverse health outcomes. Estimating the prevalence of deficiency, as well as establishing links to health outcomes, requires the accurate and precise measurement of 25-hydroxyvitamin D [25(OH)D] in serum or plasma. Accurate measurement of 25(OH)D underlies the definitions of vitamin D deficiency, insufficiency, and sufficiency and, thus, prevalence estimates...
May 11, 2017: Journal of AOAC International
Heureux Nicolas, Ernst Lindhout, Leon Swinkels
Recent studies suggest that the concentration and genotype of vitamin D binding protein (VDBP) are important factors that determine the bioavailability of 25-hydroxyvitamin D [25(OH)D] in blood. Accumulating data indicate that, e.g., in pregnant women, hemodialysis patients, chronic kidney disease, liver failure, and bladder and pancreatic cancers, the measurement of free 25(OH)D in serum provides more relevant diagnostic information than measurement of total 25(OH)D. The aim of this study was to develop and validate an ELISA for direct measurement of free 25(OH)D in serum...
May 11, 2017: Journal of AOAC International
Carolyn Q Burdette
Vitamin D is an important nutrient for many areas of human health and well-being, including improved bone strength, muscle movement, cognitive function, and immune health. The National Institute of Standards and Technology, in collaboration with the National Institutes of Health Office of Dietary Supplements, has developed SRM 3532 Calcium-Containing Solid Oral Dosage Form to help address the analytical challenges seen by the dietary supplement communities for the determination of vitamin D₃ (cholecalciferol) and elements...
May 11, 2017: Journal of AOAC International
Shelley Gorman, Mark Zafir, Ee Mun Lim, Michael W Clarke, Gursimran Dhamrait, Naomi Fleury, John P Walsh, Martin Kaufmann, Glenville Jones, Robyn M Lucas
The best management of vitamin D deficiency, defined as a 25-hydroxyvitamin D [(25(OH)D] level <50 nM, is unclear. Intramuscular (IM) injection of a large bolus of vitamin D (≥100 000 IU) is used, but its safety is uncertain. In 10 adults given an IM injection of 600 000IU vitamin D₃, we measured at baseline and at 1, 2, 3, and 4 weeks postinjection the serum levels of vitamin D₃, 25(OH)D₃, 25(OH)D₂, total 25(OH)D, 3-epi-25(OH)D₃, and 24,25-dihydroxyvitamin D₃ [24,25(OH)₂D₃] using a standardized LC with tandem MS (MS/MS) assay; serum levels of 25(OH)D using the Abbott ARCHITECT i2000 immunoassay; and markers of bone metabolism...
May 11, 2017: Journal of AOAC International
Stephen P J Brooks, Christopher T Sempos
No abstract text is available yet for this article.
May 11, 2017: Journal of AOAC International
Yan-Ying Yan, Qing-An Zhang, Er-Chun Li, Ya-Feng Zhang
Change in electrical conductivity is considered a potential indicator for the on-line monitoring of wine aging accelerated by ultrasound, as determined in our previous study; however, the exact mechanism of change is currently unclear. In this study, the ion content and the total ionic strength were analyzed by ion-exchange chromatography to investigate the change mechanism of the electrical conductivity of wine under ultrasound irradiation. The results indicate that the changes in wine electrical conductivity during ultrasound treatment correlate with the changes in the cations (Na(+), K(+), Ca(2+), Mg(2+), and NH₄(+)) and in the anions from the organic acids (malic acid, citric acid, tartaric acid, oxalic acid, and formic acid) and inorganic acids (Cl(-), SO₄(2-), and PO₄(3-)), especially for the ionic strength of the wine...
May 11, 2017: Journal of AOAC International
Andrew J Makowski, John A Rathmacher, Ronald L Horst, Christopher T Sempos
Previous studies have assessed vitamin D status based on the 25-hydroxyvitamin D [25(OH)D] concentration measured in samples from dried blood spots (DBSs). In 40 individuals participating in a clinical study, we compared 25(OH)D levels measured from DBSs and in serum using an LC-MS/MS reference procedure in collaboration with the Vitamin D Standardization Program. The main objective was to simplify and optimize current methods to produce an assay that can be used as a screening tool for 25(OH)D concentration assessment without derivatization...
May 11, 2017: Journal of AOAC International
Sofie Malmstroem, Lars Rejnmark, John B Imboden, Dolores M Shoback, Daniel D Bikle
The 25-hydroxylated metabolite of vitamin D is the best clinical indicator of vitamin D status. For many years, emphasis has been on measuring total levels of 25-hydroxyvitamin D [25(OH)D], but recently, interest in measuring free 25(OH)D as a potentially better marker of vitamin D status has arisen. Since the 1980s when the first measurements of free 25(OH)D were made, little progress has been made in the development of rapid, reliable methods to determine the levels of free 25(OH)D. For many years, assessment of free 25(OH)D relied on calculations using levels of total 25(OH)D, albumin, and vitamin D binding protein (VDBP), for which many assays exist...
May 11, 2017: Journal of AOAC International
Peter Sanders, Veronica Ernste-Nota, Klaas Visser, Jeroen van Soest, Kommer Brunt
A method using high-performance anion-exchange chromatography (HPAEC) with a pulsed amperometric detector (PAD) for thedetermination of mono- and disaccharides is described. The method was accepted by the International Dairy Federation and the Internal Organization for Standardization as a new work item for the determination of sugars in dairy matrixes, and the Milk and Milk Products technical committee of ISO/TC 34/SC 5 accepted the topic “Milk and milk products – Determination of the sugar contents – High-performance anion-exchange chromatographic method (HPAEC–PAD)” as a new work item...
May 11, 2017: Journal of AOAC International
Meng-Yan Zhang
This investigation was carried out to determine the differences in the degree of inebriation induced by Luzhou-flavor liquors having the same ethanol content. A BALB/c mouse model was used to test the effects of two liquors on the loss of the righting reflex (LORR) and the duration (DUR) of the LORR, as indices of the degree of inebriation. The blood ethanol concentration, blood acetaldehyde concentration, acetylcholinesterase activity in the hippocampus, and concentrations of dopamine and serotonin in the striatum were also determined...
May 6, 2017: Journal of AOAC International
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