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Journal of the Formosan Medical Association, Taiwan Yi Zhi

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https://www.readbyqxmd.com/read/28089494/downregulation-of-mir-1-enhances-tumorigenicity-and-invasiveness-in-oral-squamous-cell-carcinomas
#1
Chih-Yu Peng, Yi-Wen Liao, Ming-Yi Lu, Chuan-Hang Yu, Cheng-Chia Yu, Ming-Yung Chou
BACKGROUND/PURPOSE: Cumulative evidence suggest that microRNAs (miRNAs) function as biosignatures of oral squamous cell carcinomas (OSCC). However, the functional roles of miR-1 as well as its downstream targets in the regulation of tumorigenicity in OSCC remain unclear. METHODS: miRNAs RT-PCR analysis was performed to identify miR-1 as a putative candidate on mediating invasiveness of OSCC cells. Consequently, we elucidated the tumorigenicity of OSCC cells with miR-1 downregulation or overexpression, respectively...
January 12, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28089493/recent-advances-of-stroke-thrombolysis-in%C3%A2-taiwan-a-successful-interaction-between%C3%A2-physicians-regulators-and-national-health-insurance-administration
#2
Cheng-Yang Hsieh, Ruey-Tay Lin, Han-Hua Hu
No abstract text is available yet for this article.
January 12, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28089190/positron-emission-tomography-in-the-management-of-documented-or-suspected-recurrent-ovarian-cancer
#3
Hung-Hsueh Chou, Chao-Yu Chen, Feng-Yuan Liu, Gigin Lin, Chun-Chieh Wang, Lan-Yan Yang, Min-Yu Chen, Yu-Bin Pan, Ren-Chin Wu, Tzu-Chen Yen, Ting-Chang Chang, Chyong-Huey Lai
BACKGROUND: To prospectively evaluate the value of positron emission tomography (PET) or integrated computed tomography (CT) and PET (PET/CT) in the management of documented or suspected recurrent ovarian cancer. METHODS: Patients with ovarian cancer who had completed primary cytoreductive surgery and standard adjuvant chemotherapy were studied to evaluate the following indications: (1) CA125 elevation after complete remission with negative CT or magnetic resonance imaging (MRI) result; (2) post-therapy surveillance CT/MRI-detected suspicious lesions that guided biopsy was not feasible; (3) documented relapse for restaging prior to or after curative salvage therapy...
January 11, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28081867/the-central-nervous-system-patterning-gene-variants-associated-with-clinical-symptom-severity-of-autism-spectrum-disorders
#4
Yi-Ling Chien, Yu-Yu Wu, Hsin-I Chen, Wen-Che Tsai, Yen-Nan Chiu, Shih-Kai Liu, Susan Shur-Fen Gau
BACKGROUND/PURPOSE: Central nervous system (CNS) patterning genes are recognized as candidate genes for autism spectrum disorders (ASDs) based on neuroimaging and neuropathological evidence. Several genes that regulate CNS development are shown to be associated with ASD. Our previous family-based association study also revealed that a specific haplotype of WNT2 (wingless-type MMTV integration site family member 2) gene was overtransmitted to probands with ASD. Whether the CNS patterning genes moderate the clinical phenotype of ASD is unclear...
January 9, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28089092/treatment-of-de-novo-hepatitis-c-virus-related-fibrosing-cholestatic-hepatitis-after-orthotopic-heart-transplantation-by-ledipasvir-and-sofosbuvir
#5
LETTER
Chen-Hua Liu, Yih-Sharng Chen, Sheoi-Shen Wang, Jia-Horng Kao
No abstract text is available yet for this article.
January 7, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28063722/concordance-of-two-approaches-in-monitoring-of-minimal-residual-disease-in-b-precursor-acute-lymphoblastic-leukemia-fusion-transcripts-and-leukemia-associated-immunophenotypes
#6
Ying-Jung Huang, Elaine Coustan-Smith, Hsiao-Wen Kao, Hsi-Che Liu, Shih-Hsiang Chen, Chih-Cheng Hsiao, Chao-Ping Yang, Tang-Her Jaing, Ting-Chi Yeh, Ming-Chung Kuo, Chang-Liang Lai, Chia-Hui Chang, Dario Campana, Der-Cherng Liang, Lee-Yung Shih
BACKGROUND: Real-time quantitative polymerase chain reaction (RQ-PCR) for fusion transcripts and flow cytometry for leukemia-specific markers are widely used for minimal residual disease (MRD) detection in acute lymphoblastic leukemia, but the relation between the results of either method is unclear. METHODS: Mononucleated cells from 108 bone marrow samples collected from 55 B-precursor acute lymphoblastic leukemia patients (30 with t(12;21)/ETV6-RUNX1, 16 with t(9;22)/BCR-ABL1 and nine with t(1;19)/TCF3-PBX1) were examined in tandem by RQ-PCR and six-color flow cytometry...
January 4, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28057401/ruptured-extradural-vertebral-artery-aneurysm-in-a-patient-with-neurofibromatosis-type-1
#7
Chia-Ying Lin, Yu-Hsiang Shih, Ming-Tsung Chuang
No abstract text is available yet for this article.
January 2, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28038823/a-kcnq2-e515d-mutation-associated-with-benign-familial-neonatal-seizures-and-continuous-spike-and-waves-during-slow-wave-sleep-syndrome-in-taiwan
#8
Inn-Chi Lee, Jiann-Jou Yang, Shuan-Yow Li
BACKGROUND/PURPOSE: Pediatric epilepsy caused by a KCNQ2 gene mutation usually manifests as benign familial neonatal seizures (BFNS) during the 1(st) week of life. However, the exact mechanism, phenotype, and genotype of the KCNQ2 mutation are unclear. METHODS: We studied the KCNQ2 genotype from 75 nonconsanguineous patients with childhood epilepsy without an identified cause (age range: from 2 days to 18 years) and from 55 healthy adult controls without epilepsy...
December 27, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28034492/addition-of-ribavirin-to-daclatasvir-plus-asunaprevir-for-chronic-hepatitis-c-1b-patients-with-baseline-ns5a-resistance-associated-variants-improved-response
#9
Chun-Ming Hong, Chun-Jen Liu, Shiou-Hwei Yeh, Pei-Jer Chen
BACKGROUND/PURPOSE: Daclatasvir is a nonstructural protein 5A inhibitor with potent activity against hepatitis C virus genotypes 1-6 in vitro, and asunaprevir is a nonstructural protein 3 protease inhibitor with activity against genotypes 1, 4, 5, and 6. Despite a 90% sustained virologic response (SVR) rate, the SVR rate in patients with baseline NS5A-L31/Y93H polymorphisms decreased to around 40%. Therefore, an alternative regimen under the consideration of cost-effectiveness would be important...
December 26, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28034491/a-role-of-multimodality-bladder-preserving-therapy-in-patients-with-muscle-invasive-bladder-cancer-plus-hydronephrosis-with-or-without-pelvic-nodal-involvement
#10
Yun Chiang, Jason Chia-Hsien Cheng, Chao-Yuan Huang, Yu-Chieh Tsai, Chia-Chi Lin, Chih-Hung Hsu, Ann-Lii Cheng, Yeong-Shiau Pu
BACKGROUND/PURPOSE: To retrospectively evaluate the failure patterns of multimodality bladder-preserving therapy in patients with muscle-invasive bladder cancer. METHODS: Patients with muscle-invasive bladder cancer underwent maximal transurethral resection of bladder tumor and induction chemotherapy, followed by concurrent chemoradiotherapy (CCRT). Radiotherapy was given with 45 Gy to the pelvis, 50.4 Gy to the bladder, and 64.8 Gy to the tumor bed. Three protocols of trimodality treatment were used: Protocol A, three cycles of cisplatin and fluorouracil (CF), followed by CCRT with 6 weekly cisplatin; Protocol B, three cycles of weekly paclitaxel plus CF, followed by CCRT with 6 weekly paclitaxel and cisplatin; Protocol C, three cycles of gemcitabine and cisplatin, followed by CCRT with 6 weekly cisplatin...
December 26, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28024664/long-term-use-of-opioids-in-210-officially-registered-patients-with-chronic-noncancer-pain-in-taiwan-a-cross-sectional-study
#11
Tso-Chou Lin, Luo-Ping Ger, Joseph V Pergolizzi, Robert B Raffa, Ju-O Wang, Shung-Tai Ho
BACKGROUND/PURPOSE: Prescribing opioids for chronic noncancer pain has been strictly regulated for two decades in Taiwan. The aim of this study was to survey the patients' perspectives and potential drawbacks following long-term use of opioids. METHODS: An observational cross-sectional survey using the Taiwanese version of Brief Pain Inventory was conducted among outpatients with chronic noncancer pain registered by the Taiwan Food and Drug Administration. Patients were also asked about their sexual behavior, depression, opioid misuse behaviors, and use of complementary and alternative medicine...
December 23, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28012677/a-noninterventional-observational-registry-of-patients-with-multiple-myeloma-treated-with-lenalidomide-in-taiwan
#12
Shang-Yi Huang, Yuan-Bin Yu, Su-Peng Yeh, Tsai-Yun Chen, Woei-Yau Kao, Chih-Cheng Chen, Ming-Chung Wang, Hsuan-Yu Lin, Sheng-Fung Lin, Tseng-Hsi Lin, Ye Hua, Marie Puccio-Pick, Dena DeMarco, Christian Jacques, Po Dunn
BACKGROUND/PURPOSE: The incidence of multiple myeloma in Asia has risen in the past 30 years. Lenalidomide, an IMiD immunomodulatory agent, has improved the overall survival in patients with relapsed/refractory multiple myeloma (RRMM) when used with dexamethasone versus dexamethasone alone. This observational registry (T-CC-MM-009; NCT01752075) assessed the safety and efficacy of lenalidomide plus dexamethasone in a large Chinese population of patients with RRMM. METHODS: This registry followed the first 100 patients treated with lenalidomide plus dexamethasone in Taiwan...
December 21, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28012676/residents-perception-of-duty-hour-limits-through-teaching-hospital-accreditation-status-experience-in-taiwan
#13
Tsung-Hsi Wang, Brian C Drolet, Kun-Yu Tsai, Yu-Fu Liu
Residents' work overload is a rising issue in Taiwan. Duty hours of the residents in the United States have been limited by the Accreditation Council for Graduate Medical Education Common Program Requirements since 2003; similar standards were not implemented in Taiwan until 2013. Taiwanese duty hour standards are the work hour limits adopted as part of the required teaching hospital accreditation status. In January 2015, the Ministry of Health and Welfare conducted a national survey for all house officers in Taiwan...
December 21, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28012675/saccadic-entropy-of-head-impulses-in-acute-unilateral-vestibular-loss
#14
Li-Chun Hsieh, Hung-Ching Lin, Guo-She Lee
BACKGROUND/PURPOSE: To evaluate the complexity of vestibular-ocular reflex (VOR) in patients with acute unilateral vestibular loss (AUVL) via entropy analysis of head impulses. METHODS: Horizontal head impulse test (HIT) with high-velocity alternating directions was used to evaluate 12 participants with AUVL and 16 healthy volunteers. Wireless electro-oculography and electronic gyrometry were used to acquire eye positional signals and head velocity signals. The eye velocity signals were then obtained through differentiation, band-pass filtering...
December 21, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28012674/impact-of-occult-hepatitis-b-on-the-clinical-outcomes-of-patients-with-chronic-hepatitis-c-virus-infection-a-10-year-follow-up
#15
Hsing-Yu Chen, Tung-Hung Su, Tai-Chung Tseng, Wan-Ting Yang, Ting-Chih Chen, Pei-Jer Chen, Ding-Shinn Chen, Jia-Horng Kao, Chun-Jen Liu
BACKGROUND/PURPOSE: Occult hepatitis B infection (OHB) is not rare in countries that are endemic for hepatitis B virus (HBV) and in patients with chronic hepatitis C virus (HCV) infection. Notably, OHB has been shown to play a role in the progression of liver diseases, including the development of hepatocellular carcinoma (HCC); however, the data is inconsistent. We aim to clarify the contribution of concurrent OHB to the progression of liver diseases in a long-term cohort of patients with HCV infection and to investigate the value of total anti-hepatitis B core (anti-HBc) antibody as a surrogate OHB biomarker...
December 21, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28010913/serum-proteome-and-hepatitis-c-virus-further-issues-to-be-discussed
#16
LETTER
Chao-Yang Hsiao, Ching-Sheng Hsu
No abstract text is available yet for this article.
December 20, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28007466/kras-mutation-in-biliary-tract-cholangiocarcinoma
#17
LETTER
Sora Yasri, Viroj Wiwanitkit
No abstract text is available yet for this article.
December 19, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28007465/poly-l-lactic-acid-injection-induced-delayed-onset-foreign-body-granuloma
#18
Jang-Jaer Lee, Yi-Ping Wang, Yu-Hsueh Wu, Julia Yu Fong Chang
No abstract text is available yet for this article.
December 19, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28003114/does-tracheal-intubation-really-matter-discrepant-survival-between-laryngeal-mask%C3%A2-and-endotracheal-intubation-during-out-of-hospital-cardiac-arrest
#19
LETTER
Yu-Jiun Fan, Chun-Yi Dai, De-Ching Huang, Man-Ling Wang
No abstract text is available yet for this article.
December 18, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28003113/lymphoma-in-taiwan-review-of-1347-neoplasms-from-a-single-institution-according-to-the-2016-revision-of-the-world-health-organization-classification
#20
Shih-Sung Chuang, Shang-Wen Chen, Sheng-Tsung Chang, Yu-Ting Kuo
BACKGROUND: Lymphoid neoplasms are heterogeneous and types of lymphoma vary in different geographic regions. In this study, we aimed at classifying the lymphoid neoplasms at our institution in Taiwan and to compare the relative frequency of various types of lymphoma in different countries. METHODS: We retrospectively searched the files of patients diagnosed with lymphoma at our institution from 2000 to 2015 based on the 2016 Revision of the World Health Organization classification...
December 18, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
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