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Breast: Official Journal of the European Society of Mastology

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https://www.readbyqxmd.com/read/28527397/mri-surveillance-for-women-with-dense-breasts-and-a-previous-breast-cancer-and-or-high-risk-lesion
#1
Michelle Nadler, Hyder Al-Attar, Ellen Warner, Anne L Martel, Sharmila Balasingham, Liying Zhang, Joseph H Lipton, Belinda Curpen
BACKGROUND: The role of surveillance breast MRI for women with mammographically dense breasts, a personal history of breast cancer (BC), atypical hyperplasia (AH), or lobular carcinoma in situ (LCIS) is unclear. We estimated the performance of annual surveillance MRI in women with a combination of these risk factors. METHODS: We performed a retrospective review of the clinical, radiological, and pathological parameters of women who received annual concurrent surveillance breast MRI and mammography between 04/2013 and 12/2015 and fulfilled all of the following criteria: 1) age <70; 2) prior diagnosis of AH, LCIS or BC; 3) heterogeneously or extremely dense breast(s); and 4) did not qualify for our provincial breast MRI high risk screening program...
May 17, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28527396/breast-oedema-following-free-flap-breast-reconstruction
#2
Jennifer Greenhowe, Christopher Stephen, Liusaidh McClymont, D Alex Munnoch
OBJECTIVES: Breast oedema causes significant morbidity and is historically difficult to quantify. The aim of this study was to identify changes in breast tissue water content from pre-operative levels in the native breast to post-operative levels in mastectomy skin flaps and free flaps in the reconstructed breast. MATERIALS AND METHODS: One hundred patients undergoing unilateral mastectomy and immediate free flap breast reconstruction were examined pre-operatively and at three post-operative appointments...
May 17, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28526175/do-cut-off-values-of-lymph-node-ratio-and-presence-of-perineural-invasion-affect-survival-in-breast-cancer-patients-with-pathologic-n3a-lymph-node-stage-reply-to-kadri-altundag
#3
LETTER
Antonino Grassadonia, Patrizia Vici, Teresa Gamucci, Luca Moscetti, Laura Pizzuti, Lucia Mentuccia, Laura Iezzi, Maria Teresa Scognamiglio, Marinella Zilli, Jamara Giampietro, Vincenzo Graziano, Clara Natoli, Nicola Tinari
No abstract text is available yet for this article.
May 16, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28521178/impact-of-2013-asco-cap-guidelines-on-her2-determination-of-invasive-breast-cancer-a-single-institution-experience-using-frontline-dual-color-fish
#4
M Ragazzi, A Bisagni, E Gasparini, E Kuhn, C Bassano, I Tamagnini, M Foroni, M Bortesi, G Falco, G Ferrari, L Braglia, L Savoldi, A Bologna, R Di Cicilia, G Bisagni, G Gardini
PURPOSE: The new ASCO/CAP guidelines published in 2013 (AC2013) significantly modified the scoring criteria for HER2-FISH, introducing the most controversial change to the HER2-equivocal category. We retrospectively evaluated the impact of AC2013 in a cohort of consecutive invasive breast cancers (IBCs) analyzed with frontline dual-color FISH. METHODS: 2788 consecutive IBCs were reclassified based on the AC2013 guidelines. Clinico-pathological features of equivocal IBCs were compared with HER2-negative and HER2-positive IBCs...
May 15, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28505558/oncoplastic-techniques-attitudes-and-changing-practice-amongst-breast-and-plastic-surgeons-in-great-britain
#5
T Challoner, J Skillman, K Wallis, M Vourvachis, L Whisker, J Hardwicke
PURPOSE: The availability, acceptability and practice of oncoplastic surgery has increased over the last 5 years. This study aims to describe how the breast and plastic surgical workforce has adapted to provide oncoplastic breast surgery. METHODS: A questionnaire was distributed to members of the Association of Breast Surgery and BAPRAS, and results compared to a survey completed in 2010. RESULTS: In 2010, 228 respondents completed the survey compared to 237 in 2015, of whom 204 were consultants (105 General or Breast Surgeons and 99 Plastic Surgeons)...
May 12, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28505557/follow-up-of-patients-with-localized-breast-cancer-and-first-indicators-of-advanced-breast-cancer-recurrence-a-retrospective-study
#6
Julien Viot, Martin Bachour, Aurélia Meurisse, Xavier Pivot, Frédéric Fiteni
We conducted a retrospective study to assess the follow-up of patients with localized breast cancer and the first indicators of advanced breast cancer recurrence. All patients with advanced breast cancer recurrence treated between January 2010 and June 2016 in our institution were registered. Among these patients, 303 patients initially treated for early breast cancer with curative intent were identified. After initial curative treatment, follow-up involved the oncologist, the general practitioner and the gynecologist in 68...
May 12, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28502743/reply-to-garcia-j-et%C3%A2-al
#7
LETTER
Romualdo Barroso-Sousa, Nancy U Lin
No abstract text is available yet for this article.
May 11, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28500901/the-course-of-cancer-related-fatigue-up-to-ten-years-in-early-breast-cancer-patients-what-impact-in-clinical-practice
#8
Alessandra Fabi, Chiara Falcicchio, Diana Giannarelli, Gabriella Maggi, Francesco Cognetti, Patrizia Pugliese
Little is known about the cancer related fatigue (CRF) along cancer course and risk factors that could predict CRF development and persistence in breast cancer (BC) survivors. This prospective study detected incidence, timing of onset, duration of CRF, impact on QoL and psychological distress. Seventy-eight early BC patients, undergoing chemotherapy (CT) followed or not by hormonal therapy were assessed for QoL and psychological distress by EORTC QLQC30 and HADs questionnaires. Fatigue was investigated with mix methods, structured interview and psychometric measures...
May 10, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28475933/surgical-implications-and-variability-in-the-use-of-the-flat-epithelial-atypia-diagnosis-on-breast-biopsy-specimens
#9
Laura S Samples, Mara H Rendi, Paul D Frederick, Kimberly H Allison, Heidi D Nelson, Thomas R Morgan, Donald L Weaver, Joann G Elmore
OBJECTIVES: Flat epithelial atypia (FEA) is a relatively new diagnostic term with uncertain clinical significance for surgical management. Any implied risk of invasive breast cancer associated with FEA is contingent upon diagnostic reproducibility, yet little is known regarding its use. MATERIALS AND METHODS: Pathologists in the Breast Pathology Study interpreted one of four 60-case test sets, one slide per case, constructed from 240 breast biopsy specimens. An electronic data form with standardized diagnostic categories was used; participants were instructed to indicate all diagnoses present...
May 3, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28475932/therapeutic-escalation-de-escalation-data-from-15-508-early-breast-cancer-treated-with-upfront-surgery-and-sentinel-lymph-node-biopsy-slnb
#10
Gilles Houvenaeghel, Eric Lambaudie, Monique Cohen, Jean-Marc Classe, Fabien Reyal, Jean-Rémy Garbay, Sylvia Giard, Nicolas Chopin, Alejandra Martinez, Roman Rouzier, Emile Daraï, Pierre Emmanuel Colombo, Charles Coutant, Pierre Gimbergues, Pierre Azuar, Richard Villet, Christine Tunon de Lara, Emmanuel Barranger, Laura Sabiani, Anthony Goncalves
INTRODUCTION: The aim of this study was to examine changes in therapeutic practices for early breast cancer T0-2 N0 managed by upfront surgery and SLNB. POPULATION: Between 1999 and 2012, 15.508 patients were treated. Four periods were determined: 1999-2003, 2004-2006, 2007-2009 and > 2009. Five tumor subtypes were defined according to hormonal receptors (HR) and Her2: Luminal A (HR + Her2- Grade 1-2), Her2 (Her2+ HR-), Triple-negative (HR- Her2-), Luminal B Her2- (HR + Her2- Grade 3), Luminal B Her2+ (HR + HER2+)...
May 2, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28467918/higher-antitumor-activity-of-trabectedin-in-germline-brca2-carriers-with-advanced-breast-cancer-as-compared-to-brca1-carriers-a-subset-analysis-of-a-dedicated-phase-ii-trial
#11
Amal Ghouadni, Suzette Delaloge, Pilar Lardelli, Carmen Kahatt, Tomasz Byrski, Joanne L Blum, Anthony Gonçalves, Mario Campone, Antonio Nieto, Vicente Alfaro, Martin Cullell-Young, Jan Lubinski
Specific alkylators may allow synthetic lethality among patients with germline BRCA1/2-mutations related cancers. The tetrahydroisoquinolone trabectedin administered at 1.3 mg/m(2) as a 3-h intravenous infusion every 3 weeks showed activity in patients with pretreated metastatic breast cancer (MBC) and BRCA germline mutations, but mainly in BRCA2 carriers. Data from a phase II study were retrospectively analyzed to compare the efficacy and safety of this trabectedin dose and schedule in pretreated MBC patients bearing germline BRCA1/2 mutations...
April 30, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28456099/thyroid-disorders-and-mammographic-density-in-spanish-women-var-ddm-study
#12
Ana María Pedraza-Flechas, Virginia Lope, Carmen Vidal, Carmen Sánchez-Contador, Carmen Santamariña, Carmen Pedraz-Pingarrón, Pilar Moreo, Nieves Ascunce, Josefa Miranda-García, Rafael Llobet, Nuria Aragonés, Dolores Salas-Trejo, Marina Pollán, Beatriz Pérez-Gómez
OBJECTIVES: The association between breast cancer (BC) and thyroid disorders has been widely explored with unclear results. Mammographic density (MD) is one of the strongest risk factor for BC. This study explores the relationship between thyroid diseases and MD in Spanish women. MATERIALS & METHODS: This cross-sectional study covered 2883 women aged 47-71 years participating in 7 BC screening programs in 2010. They allowed access to their mammograms, had anthropometrical-measures taken, and answered a telephonic epidemiological interview which included specific questions on thyroid diseases...
April 26, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28448864/new-agents-for-endocrine-resistance-in-breast-cancer
#13
REVIEW
Christian Maurer, Samuel Martel, Dimitrios Zardavas, Michail Ignatiadis
Estrogen receptor positive (ER+) and HER2-negative (HER2-) breast cancer (BC) is the most common BC subtype, defined by expression of the ER and absence of HER2 amplification. Endocrine treatment (ET), aiming at therapeutic blockade of ER signaling, represents the therapeutic mainstay for patients with both early and advanced disease. Despite its wide therapeutic efficacy, ET fails for a proportion of ER+, HER2- BC patients with early disease who develop endocrine resistance, resulting in disease recurrence...
April 24, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28419909/reduction-in-advanced-breast-cancer-after-introduction-of-a-mammography-screening-program-in-tyrol-austria
#14
W Oberaigner, Sabine Geiger-Gritsch, M Edlinger, M Daniaux, R Knapp, M Hubalek, U Siebert, C Marth, W Buchberger
BACKGROUND: We analysed all female breast cancer (BC) cases in Tyrol/Austria regarding the shift in cancer characteristics, especially the shift in advanced BC, for the group exposed to screening as compared to the group unexposed to screening. METHODS: The analysis was based on all BC cases diagnosed in women aged 40-69 years, resident in Tyrol, and diagnosed between 2009 and 2013. The data were linked to the Tyrolean mammography screening programme database to classify BC cases as "exposed to screening" or "unexposed to screening"...
April 15, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28384565/impact-of-hormonal-status-on-outcome-of-ductal-carcinoma-in-situ-treated-with-breast-conserving-surgery-plus-radiotherapy-long-term-experience-from-two-large-institutional-series
#15
Icro Meattini, Calogero Saieva, Paolo Bastiani, Francesca Martella, Giulio Francolini, Monica Lo Russo, Lisa Paoletti, Morena Doria, Isacco Desideri, Francesca Terziani, Carla De Luca Cardillo, Benedetta Bendinelli, Cinzia Ciabatti, Cristina Muntoni, Galliano Tinacci, Jacopo Nori, Herd Smith, Beniamino Brancato, Lorenzo Galli, Luis Jose Sanchez, Donato Casella, Marco Bernini, Lorenzo Orzalesi, Giulio Alberto Carta, Simonetta Bianchi, Francesca Rossi, Lorenzo Livi
BACKGROUND: Ductal carcinoma in situ (DCIS) is a heterogeneous disease, for which the best adjuvant treatment is still uncertain. Many attempts of risk-groups stratification have been made over time, developing prognostic scores to predict risk of local recurrence (LR) on the basis of features such as age, final surgical margins (FSM) status, grade, and tumor size. The aim of our analysis was to evaluate the patterns of recurrence from a two large-institutional retrospective series. PATIENTS AND METHODS: We collected data on 457 patients treated with BCS and adjuvant RT between 1990 and 2012...
April 3, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28384563/neuropathic-pain-after-breast-cancer-treatment-and-its-impact-on-sleep-quality-one-year-after-cancer-diagnosis
#16
Filipa Fontes, Marta Gonçalves, Susana Pereira, Nuno Lunet
OBJECTIVES: Data regarding the impact of breast cancer treatment-related neuropathic pain (NP) on sleep quality are scarce. Therefore, we aimed to assess the impact of breast cancer treatment-related NP on patients' sleep quality, during the first year after cancer diagnosis. MATERIALS AND METHODS: A total of 501 breast cancer patients were followed prospectively. Incident NP was identified through systematic evaluations after treatments and one year after enrolment...
April 3, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28364669/suggestion-of-brca1-c-5339t-c-p-l1780p-variant-confer-from-unknown-significance-to-likely-pathogenic-based-on-clinical-evidence-in-korea
#17
Jai Min Ryu, Goeun Kang, Seok Jin Nam, Seok Won Kim, Jonghan Yu, Se Kyung Lee, Soo Youn Bae, Sungmin Park, Hyun-June Paik, Jong-Won Kim, Sung-Shin Park, Jeong Eon Lee, Sung-Won Kim
PURPOSE: We describe a rationale for the re-classification of the BRCA1 c.5539T>C (L1780P) variant using a clinical evidence. METHODS: A retrospective review was conducted to identify all patients with breast or ovarian cancer and the L1780P variant between 2002 and 2015 at a single institution. RESULTS: We identified the BRCA1/2 genetic mutation test results of 1223 breast cancer patients and 174 patients with ovarian cancer. Of the 160 BRCA 1/2 variant unknown significance, 16 (10...
March 29, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28363679/tumor-infiltrating-lymphocytes-in-early-breast-cancer
#18
Giancarlo Pruneri, Andrea Vingiani, Carsten Denkert
Immunoediting represents a complex and dynamic process involving cancer and immune system cells, composed by three intertwined phases: elimination, equilibrium and escape. A large number of immune cell subtypes are involved, each playing a peculiar role in interacting with cancer cells: cytotoxic CD8(+) T cells play a main role in cancer killing by inducing tumor cell death, while FOXP3+ T-regulatory cells represent an immune-inhibitory cell subtype. The evaluation of tumor infiltrating lymphocytes (TILs) in H&E routine samples has been shown to represent a reliable surrogate of the immune anti-tumor activity and a robust independent prognostic biomarker in breast cancer (BC) patients, especially in the Tripe Negative and HER2+ subtypes...
March 28, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28351000/targeted-superparamagnetic-nanoparticles-coated-with-2-deoxy-d-gloucose-and-doxorubicin-more-sensitize-breast-cancer-cells-to-ionizing-radiation
#19
Jalil Pirayesh Islamian, Milad Hatamian, Negar Abbasi Aval, Mohammad Reza Rashidi, Asghar Mesbahi, Mohammad Mohammadzadeh, Mohammad Asghari Jafarabadi
INTRODUCTION: Nanoparticles are promising as a new approach to enhance chemo- radiotherapy efficiency in breast cancer mainly via targeted therapy. MATERIALS & METHODS: SKBR3 and T47D breast cancer cells were treated with superparamagnetic mesoporous hydroxyapatite nanocomposites (SPmHANs)conjugated with 1 μM doxorubicin and 0.5 mM 2-Deoxy-d-Glucose and irradiated with 1 and 2 Gy gamma rays in vitro. The treatment toxicity and also the apoptosis/necrosis ratio were measured by MTT assay and also ELISA cell death detection PLUS, respectively...
March 25, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28347588/reply-to-h-ian-robins
#20
LETTER
Luis Ruano, Susana Pereira, Filipa Fontes, Mariana Ramalho, Nuno Lunet
No abstract text is available yet for this article.
March 24, 2017: Breast: Official Journal of the European Society of Mastology
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