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Breast: Official Journal of the European Society of Mastology

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https://www.readbyqxmd.com/read/30408714/circulating-renin-angiotensin-system-regulating-specific-aminopeptidase-activities-in-pre-and-post-menopausal-women-with-breast-cancer-treated-or-not-with-neoadyuvant-chemotherapy-a-two-years-follow-up-study
#1
María Jesús Ramírez-Exposito, Basilio Dueñas-Rodríguez, José Manuel Martínez-Martos
We have previously described changes in several circulating renin-angiotensin system (RAS)-regulating aminopeptidase activities in pre- and postmenopausal women with breast cancer treated or not with neoadjuvant chemotherapy. Women with breast cancer presented a reduced catabolism of angiotensin II (AngII) when compared to healthy individuals, although specific enzyme activities were different between pre- and post- menopausal women. In addition, neoadjuvant chemotherapy in breast cancer patients caused changes in aminopeptidase activities leading to increased AngII catabolism independently of hormonal status...
November 1, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30388502/how-to-become-a-breast-cancer-specialist-in-2018-the-point-of-view-of-the-second-cohort-of-the-certificate-of-competence-in-breast-cancer-ccb2
#2
Giacomo Montagna, David Anderson, Justyna Bochenek-Cibor, Ivana Bozovic-Spasojevic, Conceicao Campos, Sandro Cavallero, Ivana Durutovic, Manuel Oscar Gomez Cuadra, Tazia Irfan, Laetita Joly, Loay Kassem, Theresa M Kolben, Martina Machacek, Benazir Mir Khan, Mayur Nagvekar, Benedetta Pellegrino, Katarzyna Pogoda, Gabriela Rodrigues Câmara, Pedro Santos Ferreira, Melsi Seferi, Narmin Talibova, Nathalie Van den Rul, Elen Vettus, Nicola Rocco
Breast cancer (BC) is the most frequent cancer in women and the leading cause of cancer death in females worldwide. Rapid research advancements add to the complexity of treatment options for this disease. It is known that the quality of patients' care is deeply affected by healthcare professionals following these advancements. There is a growing need for academic education to increase clinical knowledge and skills of physicians treating BC patients. The certificate of Competence in Breast Cancer Program (CCB) is a Certificate in Advanced Studies (CAS) organized by the European School of Oncology in cooperation with Ulm University (Germany), which focuses on both the clinical and scientific competence required for improving quality in the management of BC patients...
October 22, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30391832/treatment-patterns-and-clinical-outcomes-among-patients-receiving-palbociclib-in-combination-with-an-aromatase-inhibitor-or-fulvestrant-for-hr-her2-negative-advanced-metastatic-breast-cancer-in-real-world-settings-in-the-us-results-from-the-iris-study
#3
Gavin Taylor-Stokes, Debanjali Mitra, John Waller, Katie Gibson, Gary Milligan, Shrividya Iyer
PURPOSE: Palbociclib is a selective cyclin-dependent kinase (CDK) 4/6 inhibitor approved for use in postmenopausal women with hormone receptor-positive, human epidermal growth factor 2-negative (HR+/HER2-) advanced/metastatic breast cancer (ABC/MBC). Palbociclib has proven benefits in phase III placebo-controlled studies; however, real-world outcome data are lacking. The Ibrance Real World Insights (IRIS) study evaluated palbociclib use in patients with HR+/HER2- ABC/MBC in the real-world setting in the US, Argentina, and Germany...
October 20, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30385097/reply-to-the-letter-safety-of-fertility-preservation-in-women-with-breast-cancer
#4
LETTER
Matteo Lambertini, Paola Anserini, Lucia Del Mastro
No abstract text is available yet for this article.
October 19, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30415143/mirna-27a-sensitizes-breast-cancer-cells-to-treatment-with-selective-estrogen-receptor-modulators
#5
Bojan Ljepoja, Jonathan García-Roman, Ann-Katrin Sommer, Ernst Wagner, Andreas Roidl
BACKGROUND: MicroRNA-27a (miR-27a) is a small non-coding RNA, shown to play a role in multiple cancers, including the regulation of ERα expression in breast cancer. Most ERα positive tumors are treated with Selective Estrogen Receptor Modulators (SERMs) and thus the role of miR-27a expression in response to SERM treatment is of interest. METHODS: Tamoxifen resistant cells were generated by molecular evolution with six cycles of tamoxifen treatment. MCF7 and T47D luminal A breast cancer cell lines were either treated with miR-27a mimics, or ER-signaling was modulated ectopically...
October 18, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30342259/corrigendum-to-quality-of-life-evolution-in-elderly-survivors-with-localized-breast-cancer-treated-with-radiotherapy-over-a-three-year-follow-up-breast-41-october-2018-74-81
#6
Juan Ignacio Arraras, Ana Manterola, Jose Juan Illarramendi, Gemma Asin, Susana de la Cruz, Berta Ibañez, Arkaitz Galbete, Esteban Salgado, Uxue Zarandona, Ruth Vera, Miguel Angel Dominguez, Enrique Martinez
No abstract text is available yet for this article.
October 17, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30342258/ribociclib-in-hormone-receptor-positive-advanced-breast-cancer-establishing-a-value-based-cost-in-china
#7
XiaoMin Wan, YuCong Zhang, JinAn Ma, Chongqing Tan, XiaoHui Zeng, LiuBao Peng
BACKGROUND: The addition of ribociclib (RIB) to letrozole (LET) significantly increases progression free survival for patients with hormone-receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer (ABC). We identified the range of drug costs for which RIB could be considered cost effective from a Chinese perspective. METHODS: A discrete event simulation model was developed to model the treatment sequences among patients with ABC...
October 16, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30336339/erbb4-receptor-polymorphism-2368a-c-and-risk-of-breast-cancer
#8
Masoumeh Mansouri Bidkani, Hossein Tabatabaeian, Soha Parsafar, Nafezeh Ghanei, Mohammad Fazilati, Kamran Ghaedi
PURPOSE: A number of single nucleotide polymorphisms (SNPs) in EebB4 gene have been studied, which has clarified their impact on breast cancer in different populations. Nevertheless, the importance of rs13423759 in breast cancer has not been studied and its effect remained almost unclear. In this paper, we evaluated the frequency of rs13423759 different alleles in Iranian population and statistically analyzed their association with breast cancer risk. MATERIALS AND METHODS: Allele-specific Primer PCR (ASP-PCR) was recruited in this study to genotype rs13423759 position in 172 breast cancer and 148 healthy control subjects...
October 9, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30359883/targeting-cdk4-6-pathways-and-beyond-in-breast-cancer
#9
Domen Ribnikar, Simona Ruxandra Volovat, Fatima Cardoso
Metastatic or advanced breast cancer (mBC/ABC) remains incurable despite many different systemic treatment options. Hormone receptor positive (HR+) disease represents the most common subtype in both early and advanced disease. A better understanding of the biology of this BC subtype, in particular regarding potential mechanisms of endocrine resistance, has led to the development of CDK4/6 inhibitors. All three selective CDK4/6 inhibitors, palbociclib, ribociclib and abemaciclib have shown to significantly improve progression-free survival (PFS) when combined to endocrine therapy as first-line treatment for patients with HR+/HER-2 negative ABC, who have progressed on or after adjuvant endocrine therapy...
October 8, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30293676/safety-of-fertility-preservation-in-women-with-breast-cancer
#10
LETTER
Kenny A Rodriguez-Wallberg, Annelie Liljegren
No abstract text is available yet for this article.
October 2, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30296647/trace-element-concentrations-in-breast-cancer-patients
#11
Noemí Cabré, Fedra Luciano-Mateo, Meritxell Arenas, Martí Nadal, Gerard Baiges-Gaya, Anna Hernández-Aguilera, Isabel Fort-Gallifa, Elisabet Rodríguez, Francesc Riu, Jordi Camps, Jorge Joven, José Luis Domingo
Alterations in the circulating levels of trace elements have been observed in breast cancer (BC) patients. However, the relationships between these alterations and the metabolic and clinical consequences of BC are unknown. The treatment-of-choice of BC is surgery followed by radiation therapy (RT). The present study was aimed at investigating: 1) the concentrations of several trace elements in BC patients, and their relationships with the intrinsic molecular subtypes of tumors; 2) the toxicological effect of RT...
October 1, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30296648/treatment-outcomes-of-breast-cancer-liver-metastasis-treated-with-stereotactic-body-radiotherapy
#12
Cem Onal, Ozan Cem Guler, Berna Akkus Yildirim
BACKGROUND: To assess the outcomes of breast cancer liver metastasis (BCLM) treated with stereotactic body radiotherapy (SBRT) and systemic treatment. MATERIALS AND METHODS: Patients with oligometastasis at the time of liver metastasis (LM) or who became oligometastatic (≤5 metastases) after systemic treatment were assessed. Twenty-nine liver metastatic lesions were treated with a total of 54 Gy delivered in 3 fractions. The local control (LC), overall survival (OS), and progression-free survival (PFS) rates were calculated using Kaplan-Meier analyses...
September 29, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30257226/risk-factors-of-sentinel-and-non-sentinel-lymph-node-metastases-in-patients-with-ductal-carcinoma-in-situ-of-the-breast-a-nationwide-study
#13
Emil Villiam Holm-Rasmussen, Maj-Britt Jensen, Eva Balslev, Niels Kroman, Tove Filtenborg Tvedskov
OBJECTIVES: Unexplained axillary metastases have been detected in some patients with ductal carcinoma in situ (DCIS), possibly because of occult invasion or iatrogenic tumor cell displacement. The significance of these metastases is unknown and brings into questions the need for upstaging and axillary surgery. What are the risk factors for sentinel lymph node (SN) and non-SN metastases, including the risk of iatrogenic displacement of tumor cells in relation to an excisional biopsy, in patients diagnosed with DCIS? METHODS: Nationwide data on 1787 women diagnosed with DCIS between 2001 and 2015 were retrieved from the Danish Breast Cancer Group database...
September 18, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30278369/the-presentation-management-and-outcome-of-inflammatory-breast-cancer-cases-in-the-uk-data-from-a-multi-centre-retrospective-review
#14
E Copson, A M Shaaban, T Maishman, P M Moseley, H McKenzie, J Bradbury, A Borley, M Brzezinska, S Y T Chan, J Ching, R I Cutress, I Danial, B Dall, M Kerin, A J Lowery, I R Macpherson, L Romics, E Sawyer, N Sharmat, T Sircar, R Vidya, Y Pan, D Rea, L Jones, D M Eccles, F Berditchevski
OBJECTIVES: Inflammatory Breast cancer (IBC) is a rare but aggressive form of breast cancer. Its incidence and behaviour in the UK is poorly characterised. We collected retrospective data from hospitals in the UK and Ireland to describe the presentation, pathology, treatment and clinical course of IBC in the UK. MATERIALS AND METHODS: Patients with IBC diagnosed between 1997-2014 at fourteen UK and Irish hospitals were identified from local breast unit databases...
September 15, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30236594/the-impact-of-legislation-mandating-breast-density-notification-review-of-the-evidence
#15
REVIEW
Nehmat Houssami, Christoph I Lee
Breast density (BD) is an independent risk factor for breast cancer and reduces the sensitivity of mammography. The enactment of BD legislation in a majority of states in the USA mandating notification of risks associated with BD directly to women undergoing mammography has catapulted interest in BD among women, physicians, and policymakers. We therefore report a descriptive review of the evidence on the impact of enactment of BD legislation. Based on 22 eligible studies, we identified four broad themes of research: studies of the impact on screening rates, most showing increased utilisation of supplemental screening; studies exploring the effect on women, radiologists, or primary physicians (reporting heterogeneous effects on knowledge, awareness, perceptions, attitudes and behaviour; and changes in practice); few studies assessing the population impact (effect on screening outcomes or breast cancer stage); and studies of costs highlighting the economic burden from supplemental screening...
September 11, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30243159/prevalence-of-pain-in-patients-with-breast-cancer-post-treatment-a-systematic-review
#16
REVIEW
Katie Wang, Caitlin Yee, Samantha Tam, Leah Drost, Stephanie Chan, Pearl Zaki, Victoria Rico, Krista Ariello, Mark Dasios, Henry Lam, Carlo DeAngelis, Edward Chow
PURPOSE: To evaluate the prevalence and severity of persistent pain after breast cancer treatment (PPBCT) in patients who received surgery, radiotherapy or a combination of treatments and to explore how different treatments and techniques impact pain. METHODS: Medline, Embase and Cochrane Central databases were searched for articles which evaluated the prevalence of PPBCT. Search results were limited to studies addressing chronic post-surgical pain (CPSP), persistent post-surgical pain (PPSP), post-mastectomy pain syndrome (PMPS) or radiotherapy (RT) related pain in breast cancer patients and published in the English language...
September 4, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30189381/expression-of-ny-eso-1-mage-a3-prame-and-wt1-in-different-subgroups-of-breast-cancer-an-indication-to-immunotherapy
#17
Anna Tessari, Lorenzo Pilla, Damian Silvia, Matteo Duca, Biagio Paolini, Maria Luisa Carcangiu, Luigi Mariani, Filippo G de Braud, Sara Cresta
OBJECTIVES: Cancer Testis Antigens are immunogenic tumor-specific proteins. We investigated NY-ESO-1, MAGE-A3 and PRAME, in addition to WT1 expression in different Breast Cancer (BC) subtypes. We then evaluated the expression rate of NY-ESO-1 in early Triple Negative breast cancer (TNBC), and investigated whether its expression would be maintained or lost in the metastatic setting to explore possible immunotherapy indication. MATERIALS AND METHODS: Three subgroups of BC patients were selected by the expression of ER, PgR and Her2...
August 29, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30216838/frequency-and-characteristics-of-additionally-detected-ipsilateral-breast-lesions-following-recall-at-screening-mammography
#18
Joost Rc Lameijer, Angela Mp Coolen, Joost Nederend, Adri C Voogd, Vivianne Cg Tjan-Heijnen, Lucien Em Duijm
PURPOSE: To determine the frequency and outcome of additionally detected ipsilateral breast abnormalities following recall at screening mammography. METHODS AND MATERIALS: We included a consecutive series of 130,338 screening mammograms obtained between January 1, 2014 and January 1, 2016. During 2-year follow-up, clinical data were collected of all recalls. Women with a bilateral recall (115) and women recalled for multiple lesions in one breast (165) were excluded from the analyses...
August 28, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30179779/chemosensitivity-tumor-infiltrating-lymphocytes-tils-and-survival-of-postpartum-pabc-patients-treated-by-neoadjuvant-chemotherapy
#19
Julie Labrosse, Inès Abdennebi, Lucie Thibault, Enora Laas, Hilde Merckelbagh, Charlotte Morel, Thanh Lam, Marick Lae, Fabien Reyal, Anne-Sophie Hamy
BACKGROUND: Pregnancy-associated breast cancer (PABC) refers to breast cancers (BC) diagnosed during pregnancy or shortly after birth. Although the inflammatory environment of post-partum PABC cases (designed as PP-PABC) may be deleterious, so far PP-PABC have scarcely been distinguished from breast cancers diagnosed during pregnancy. Furthermore, whether PP-PABC cases have an enhanced immune infiltration remains unknown. We investigated chemosensitivity, immune infiltration and survival of PP-PABC patients treated by neoadjuvant chemotherapy (NAC) compared to non-PABC matched BC patients...
August 28, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30199761/a-systematic-review-of-women-s-knowledge-of-screening-mammography
#20
REVIEW
Kristen Seaman, Peta L Dzidic, Emily Castell, Christobel Saunders, Lauren J Breen
In light of the contention surrounding the benefit-to-harm ratio of screening mammography, this systematic review aimed to understand women's knowledge of screening mammography. The search yielded 35 studies of varying methodologies, published/completed between 1992 and 2017. Data was collected between November 2017 and February 2018 and utilised publications from member countries of the International Cancer Screening Network- Breast Cancer Division. Data was analysed using a narrative synthesis. The results of the review suggest that most women are aware of mammograms, however there was large variability regarding the awareness of false positives/negatives and about the purpose of screening...
August 27, 2018: Breast: Official Journal of the European Society of Mastology
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