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Breast: Official Journal of the European Society of Mastology

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https://www.readbyqxmd.com/read/29161653/psychosocial-issues-of-a-population-approach-to-high-genetic-risk-identification-behavioural-emotional-and-informed-choice-issues
#1
David P French, Anthony Howell, D Gareth Evans
To allow women at high genetic risk of breast cancer to benefit from prevention or early prevention strategies, a screening programme is required to identify them. The present review considers the likelihood of key outcomes that would arise from such a programme, in relation to behavioural, emotional and informed choice outcomes. The likelihood of outcomes in each category is considered in relation to the limited direct evidence and relevant indirect evidence, given the dearth of studies that have directly studied the effects of communication of personal genetic risk of breast cancer...
November 18, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29161652/impact-of-body-mass-index-on-the-clinical-outcomes-of-patients-with-her2-positive-metastatic-breast-cancer
#2
Samuel Martel, Elena Poletto, Arlindo R Ferreira, Matteo Lambertini, Federico Sottotetti, Ilaria Bertolini, Filippo Montemurro, Antonio Bernardo, Emanuela Risi, Elisa Zanardi, Serena Ziliani, Silvia Mura, Chiara Dellepiane, Lucia Del Mastro, Alessandro Marco Minisini, Fabio Puglisi
BACKGROUND: Overweight and obesity are associated with an increased risk of developing many types of cancer, including breast cancer. Moreover, increased body mass index (BMI) seems to be associated with a worse prognosis in patients with HER2-positive early breast cancer. However, little is known about the impact of BMI on the clinical outcomes of HER2-positive metastatic breast cancer (MBC). METHODS: This was a multicenter retrospective cohort study including 329 consecutive patients with HER2-positive MBC treated with first-line trastuzumab-based regimens...
November 18, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29156385/interaction-with-the-gdf8-11-pathway-reveals-treatment-options-for-adenocarcinoma-of-the-breast
#3
Christoph Wallner, Marius Drysch, Mustafa Becerikli, Henriette Jaurich, Johannes Maximilian Wagner, Stephanie Dittfeld, Julia Nagler, Kamran Harati, Mehran Dadras, Stathis Philippou, Marcus Lehnhardt, Björn Behr
Breast adenocarcinoma continues to be the most frequently diagnosed tumor entity. Despite established therapy options, mortality for breast cancer remains to be as high as 40,000 patients in the US annually. Thus, a need to develop a patient-oriented, targeted therapy exists. In this study, we investigated the interaction of breast adenocarcinoma with the ubiquitously present protein Follistatin and subsequently the GDF8/11 pathway. We analyzed primary histological samples from adenocarcinoma patients for expression of Follistatin and GDF8/11...
November 17, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29156384/targeting-fgfr-pathway-in-breast-cancer
#4
J Perez-Garcia, E Muñoz-Couselo, J Soberino, F Racca, J Cortes
Developments in breast cancer biology over the last years have permitted deconstructing the molecular profile of the most relevant breast cancer subtypes. This has led to an increase in therapeutic options, including more effective personalized therapy for breast cancer and substantial improvements in patient outcomes. Although currently there are only a few targeted therapies approved for metastatic breast cancer, the discovery of druggable kinase gene alterations has radically changed cancer treatment by providing novel and successfully actionable drug targets...
November 17, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29145033/is-chronic-postsurgical-pain-surgery-induced-a-study-of-persistent-postoperative-pain-following-breast-reconstruction
#5
Randy S Roth, Ji Qi, Jennifer B Hamill, Hyungjin M Kim, Tiffany N S Ballard, Andrea L Pusic, Edwin G Wilkins
BACKGROUND: Chronic postsurgical pain (CPSP) is a reported risk for women undergoing breast reconstruction, but it remains unclear that such persistent pain is induced by reconstructive surgery. To address this concern, this prospective cohort study examined the prevalence of and risk factors associated with CPSP among women undergoing breast reconstruction. MATERIALS AND METHODS: Women (n = 1996) recruited for the Mastectomy Reconstruction Outcomes Consortium (MROC) Study were assessed preoperatively and at two-years postoperatively for relevant medical/...
November 13, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29136523/the-advantages-of-hypnosis-intervention-on-breast-cancer-surgery-and-adjuvant-therapy
#6
M Berlière, F Roelants, C Watremez, M A Docquier, N Piette, S Lamerant, V Megevand, A Van Maanen, P Piette, A Gerday, F P Duhoux
BACKGROUND: In oncology, hypnosis has been used for pain relief in metastatic patients but rarely for induction of anesthesia. MATERIAL AND METHOD: Between January 2010 and October 2015, 300 patients from our Breast Clinic (Cliniques universitaires Saint-Luc, Université catholique de Louvain) were included in an observational, non-randomized study approved by our local ethics committee (ClinicalTrials.gov - NCT03003611). The hypothesis of our study was that hypnosis intervention could decrease side effects of breast surgery...
November 11, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29131988/treatment-adoption-and-relative-effectiveness-of-aromatase-inhibitors-compared-to-tamoxifen-in-early-breast-cancer-a-multi-institutional-observational-study
#7
Arlindo R Ferreira, Ana Palha, Lurdes Correia, Pedro Filipe, Vasco Rodrigues, Ana Miranda, Rosário André, João Fernandes, Joaquim Gouveia, José L Passos-Coelho, António Moreira, Margarida Brito, Joana Ribeiro, Otto Metzger-Filho, Nancy U Lin, Luís Costa, Inês Vaz-Luis
BACKGROUND: Since 2005, aromatase inhibitors (AIs) have been the adjuvant treatment of choice for postmenopausal women with early breast cancer (BC). In this study we characterize the adoption of AIs in Portugal, variables associated with treatment administration, and compare its effectiveness (either in monotherapy or sequential therapy) to tamoxifen monotherapy (TAM). PATIENTS AND METHODS: This was a retrospective cohort study that included postmenopausal women with stage I-III hormone receptor (HR) positive BC diagnosed from 2006 to 2008 and treated with adjuvant endocrine therapy in four participating institutions...
November 10, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29128583/patients-experiences-with-decisions-on-timing-of-chemotherapy-for-breast-cancer
#8
K M de Ligt, P E R Spronk, A C M van Bommel, M T F D Vrancken Peeters, S Siesling, C H Smorenburg
INTRODUCTION: Despite potential advantages, application of chemotherapy in the neo-adjuvant (NAC) instead of adjuvant (AC) setting for breast cancer (BC) patients varies among hospitals. The aim of this study was to gain insight in patients' experiences with decisions on the timing of chemotherapy for stage II and III BC. MATERIALS AND METHODS: A 35-item online questionnaire was distributed among female patients (age>18) treated with either NAC or AC for clinical stage II/III invasive BC in 2013-2014 in the Netherlands...
November 9, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29128582/budget-impact-analysis-of-gene-expression-tests-to-aid-therapy-decisions-for-breast-cancer-patients-in-germany
#9
M P Lux, N Nabieva, T Hildebrandt, H Rebscher, S Kümmel, J-U Blohmer, M G Schrauder
OBJECTIVES: Many women with early-stage, hormone receptor-positive breast cancer may not benefit from adjuvant chemotherapy. Gene expression tests can reduce chemotherapy over- and undertreatment by providing prognostic information on the likelihood of recurrence and, with Oncotype DX, predictive information on chemotherapy benefit. These tests are currently not reimbursed by German healthcare payers. An analysis was conducted to evaluate the budget impact of gene expression tests in Germany...
November 9, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29117902/editorial-approaches-of-the-treatment-of-dcis
#10
EDITORIAL
Steven A Narod
No abstract text is available yet for this article.
November 5, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29102782/metastasis-free-interval-in-breast-cancer-patients-thirty-year-trends-and-time-dependency-of-prognostic-factors-a-retrospective-analysis-based-on-a-single-institution-experience
#11
A Houzé de l'Aulnoit, B Rogoz, C Pinçon, D Houzé de l'Aulnoit
INTRODUCTION: Breast cancer remains the leading cause of cancer death in French women in spite of continuously improving management. The objectives of this study were to analyse trends in the metastasis-free interval over the past 30 years and to identify the prognostic factors of survival, while accounting for time dependency. METHODS: A total of 1613 patients diagnosed with invasive non-metastatic breast cancer at Saint Vincent de Paul Hospital, Lille, France between 1977 and 2013, were followed for outcome (metastasis-free interval)...
November 2, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29102781/outcomes-of-immediate-versus-delayed-breast-reconstruction-results-of-a-multicenter-prospective-study
#12
Alfred P Yoon, Ji Qi, David L Brown, Hyungjin M Kim, Jennifer B Hamill, Jessica Erdmann-Sager, Andrea L Pusic, Edwin G Wilkins
BACKGROUND: Previous studies suggest that immediate reconstruction following mastectomy produces superior results over delayed procedures. However, for medical or oncological reasons, some patients may be poor candidates for immediate reconstruction. We compared complications and patient-reported outcomes between immediate and delayed breast reconstructions in a prospective, multicenter study. METHODS: 1957 patients (1806 immediate, 151 delayed) met eligibility criteria...
November 2, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29101824/effect-of-prophylactic-betablocker-or-ace-inhibitor-on-cardiac-dysfunction-heart-failure-during-anthracycline-chemotherapy%C3%A2-%C3%A2-%C3%A2-trastuzumab
#13
Dorothy M Gujral, Guy Lloyd, Sanjeev Bhattacharyya
BACKGROUND: Administration of anthracycline chemotherapy ± trastuzumab is associated with cardiac dysfunction. We sought to identify whether prophylactic administration of angiotensin converting enzyme (ACE) inhibitor or beta-blocker attenuates subsequent left ventricular dysfunction and heart failure. METHODS: Electronic databases were searched for studies examining the effect of beta-blockers or ACE inhibitors on left ventricular ejection fraction (LVEF) and heart failure in patients receiving anthracycline chemotherapy ± trastuzumab...
November 1, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29100639/radiation-therapy-after-breast-conserving-surgery-increases-long-term-breast-conservation-for-dcis-patients
#14
EDITORIAL
Orit Kaidar-Person, Icro Meattini, Philip Poortmans
No abstract text is available yet for this article.
October 31, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29100045/evaluation-of-the-prognostic-stage-in-the-8th-edition-of-the-american-joint-committee-on-cancer-in-locally-advanced-breast-cancer-an-analysis-based-on-seer-18-database
#15
Maoli Wang, Hongliang Chen, Kejin Wu, Ang Ding, Mingdi Zhang, Peng Zhang
BACKGROUND: The new "prognostic stage" in the 8th edition of the American Joint Committee on Cancer (AJCC) incorporated important biologic factors such as estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER2), histologic grade and TNM stage into one system. The objective of this study was to evaluate the "prognostic stage" in locally advanced breast cancer (LABC) based on the Surveillance, Epidemiology, and End Results (SEER) 18 database. METHODS: 10053 LABCs diagnosed between 2010 and 2013 were enrolled...
October 31, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29100044/a-plea-for-appraisal-and-appreciation-of-immunohistochemistry-in-the-assessment-of-prognostic-and-predictive-markers-in-invasive-breast-cancer
#16
Mieke Van Bockstal, Giuseppe Floris, Christine Galant, Kathleen Lambein, Louis Libbrecht
This viewpoint is a personal reflection on the values and merits of immunohistochemistry in current breast cancer diagnosis. Immunohistochemistry is a validated mainstay in molecular subtyping of invasive breast cancer. Immunohistochemical assessment of hormone receptor status and HER2 expression is used to determine the clinico-pathological surrogate of breast cancer intrinsic subtypes, which guide neoadjuvant and adjuvant therapy. The advent of genomic prognostic signatures and qualitative mRNA-based assays makes some clinicians and researchers wonder whether immunohistochemistry should be abandoned...
October 31, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29100043/treatment-landscape-of-advanced-breast-cancer-patients-with-hormone-receptor-positive-her2-negative-tumors-data-from-the-german-praegnant-breast-cancer-registry
#17
Andreas D Hartkopf, Jens Huober, Bernhard Volz, Naiba Nabieva, Florin-Andrei Taran, Judith Schwitulla, Friedrich Overkamp, Hans-Christian Kolberg, Peyman Hadji, Hans Tesch, Lothar Häberle, Johannes Ettl, Michael P Lux, Diana Lüftner, Markus Wallwiener, Volkmar Müller, Matthias W Beckmann, Erik Belleville, Pauline Wimberger, Carsten Hielscher, Matthias Geberth, Nikos Fersis, Wolfgang Abenhardt, Christian Kurbacher, Rachel Wuerstlein, Christoph Thomssen, Michael Untch, Peter A Fasching, Wolfgang Janni, Tanja N Fehm, Diethelm Wallwiener, Sara Y Brucker, Andreas Schneeweiss
PURPOSE: This study describes comprehensive data from a breast cancer registry concerning the use of endocrine treatment (ET) and chemotherapy in the first, second and higher therapy lines in hormone receptor (HR) positive, HER2 negative metastatic breast cancer (MBC). METHODS: The PRAEGNANT study is a real-time registry for patients with MBC. Therapies were categorized into the following categories: chemotherapy, aromatase inhibitor (AI), tamoxifen, fulvestrant, or everolimus plus ET and reported for first, second and third line or higher therapy use...
October 26, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29073498/external-validation-of-modified-breast-graded-prognostic-assessment-for-breast-cancer-patients-with-brain-metastases-a-multicentric-european-experience
#18
Gaia Griguolo, William Jacot, Eva Kantelhardt, Maria Vittoria Dieci, Céline Bourgier, Christoph Thomssen, Caroline Bailleux, Federica Miglietta, Antoine-Laurent Braccini, PierFranco Conte, Jean Marc Ferrero, Valentina Guarneri, Amélie Darlix
BACKGROUND: Several prognostic scores have been developed to estimate survival of breast cancer (BC) patients with brain metastases (BM). Modified Breast Graded Prognostic Assessment (GPA), based on a single-institution cohort of 1552 patients, has been proposed as refinement of Breast-GPA. In addition to age, tumour subtype and KPS, Modified Breast-GPA comprises number of BM. This study was designed to validate Modified Breast-GPA. PATIENTS AND METHODS: Clinical data of 668 BC patients diagnosed with BM at four institutions between 1996 and 2016 were reviewed...
October 23, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29073497/therapeutic-approaches-for-protecting-bone-health-in-patients-with-breast-cancer
#19
REVIEW
Diana Lüftner, Daniela Niepel, Guenther G Steger
Improvements in the survival of patients with breast cancer, together with a better understanding of the pathology of the disease, have led to the emergence of bone health as a key aspect of patient management. Patients with breast cancer are typically at risk of skeletal complications throughout their disease course. The receptor activator of nuclear factor κ B ligand (RANKL) inhibitor denosumab and bisphosphonates (e.g. zoledronic acid) are approved in Europe for the prevention of skeletal-related events (pathologic fracture, radiation or surgery to bone, and spinal cord compression) in adults with bone metastases secondary to solid tumours...
October 23, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29059538/effects-of-the-chinese-medicine-yi-shen-jian-gu-granules-on-aromatase-inhibitor-associated-musculoskeletal-symptoms-a-randomized-controlled-clinical-trial
#20
Nan Peng, Mingwei Yu, Guowang Yang, Qi Fu, Yongmei Xu, Jie Yu, Qiang Liu, Chen Li, Weiru Xu, Yi Zhang, Cong Ma, Lin Yang, Rencun Yu, Xiaomin Wang
Aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) are prevalent among patients on AI therapy, which leads to a lower quality of life and poor adherence to AI treatment. We evaluated whether Yi Shen Jian Gu granules (YSJG) is effective and safe to relieve AIMSS in patients with breast cancer. Eligible participants were randomly assigned to the YSJG group or the placebo group. Both groups had a 12-week treatment period and a 12-week follow-up period. Brief Pain Inventory-Short Form (BPI-SF), Western Ontario and McMaster Universities Osteoarthritis (WOMAC) Index, and the Modified Score for the Assessment and Quantification of Chronic Rheumatoid Affections of the Hands (M-SACRAH) were obtained at baseline and at 4, 8, 12 and 24 weeks...
October 20, 2017: Breast: Official Journal of the European Society of Mastology
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