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Breast: Official Journal of the European Society of Mastology

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https://www.readbyqxmd.com/read/29783185/impact-of-body-mass-index-on-the-efficacy-of-endocrine-therapy-in-patients-with-metastatic-breast-cancer-a-retrospective-two-center-cohort-study
#1
Luwam Zewenghiel, Henrik Lindman, Antonis Valachis
BAKGROUND: The aim of this study was to investigate the impact of body mass index (BMI) on the efficacy of endocrine therapy in postmenopausal women with metastatic hormone receptor breast cancer (HR+BC) as well as to identify if the potential difference in efficacy was associated with Fulvestrant only or both aromatase inhibitors (AIs) and Fulvestrant. METHODS: A consecutive cohort of postmenopausal women with HR+metastatic breast cancer that have received endocrine therapy including Fulvestrant as a metastatic treatment strategy at the Departments of Oncology in Eskilstuna and Uppsala, Sweden, between 2008 and 2016 were identified...
May 18, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29772517/dynamics-of-the-hazard-for-distant-metastases-after-ipsilateral-breast-tumor-recurrence-according-to-estrogen-receptor-status-an-analysis-of-2851-patients
#2
Massimiliano Gennaro, Serena Di Cosimo, Ilaria Ardoino, Silvia Veneroni, Luigi Mariani, Roberto Agresti, Maria Grazia Daidone, Filippo de Braud, Giovanni Apolone, Elia Biganzoli, Romano Demicheli
BACKGROUND: Breast cancer (BC) patients with ipsilateral breast tumor recurrence (IBTR) are at high risk of developing distant metastases (DM). We aimed to evaluate the risk pattern of developing DM, with respect to the occurrence of IBTR, in a large series of patients homogeneously treated by conservative surgery (QUART) with a considerably long follow-up. METHODS: Piecewise exponential model was used to investigate DM dynamics conditioning on known prognostic factors and IBTR occurrence as time dependent covariate...
May 14, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29763858/the-oncologic-impact-of-hormone-replacement-therapy-in-premenopausal-breast-cancer-survivors-a-systematic-review
#3
REVIEW
Yimeng Wang, Naomi Lewin, Yazan Qaoud, A Nikoo Rajaee, Adena S Scheer
SYNOPSIS: This is the first systematic review to investigate the risk of recurrence in breast cancer survivors <50 years old who have used hormone replacement therapy (HRT). BACKGROUND: The risk of HRT in premenopausal breast cancer survivors is unclear. Due to the higher incidence of estrogen receptor negative tumours in women <50, the potential for HRT to promote breast cancer recurrence may differ from older age groups. METHODS: We performed a search of Medline, EMBASE and CINAHL through June 2016...
May 12, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29758504/patients-perspectives-and-experiences-concerning-barriers-to-accessing-information-about-bilateral-prophylactic-mastectomy
#4
Rachael Glassey, Moira O'Connor, Angela Ives, Christobel Saunders, kConFab Investigators, Sarah O'Sullivan, Sarah J Hardcastle
PURPOSE: To explore the barriers and experiences of accessing information for women who have received genetic risk assessment/testing results for breast cancer (BC) and are considering a bilateral prophylactic mastectomy (BPM) and, exploring participants' preferences concerning information and support needs. METHODS: A qualitative retrospective study guided by interpretative phenomenological analysis was utilised. Semi-structured interviews were conducted with forty-six women who were either considering BPM or had already undergone the surgery...
May 11, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29758503/mri-and-pet-ct-for-evaluation-of-the-pathological-response-to-neoadjuvant-chemotherapy-in-breast-cancer-a-systematic-review-and-meta-analysis
#5
REVIEW
Huimin Li, Liang Yao, Penghui Jin, Lidong Hu, Xiaofei Li, Tiankang Guo, Kehu Yang
BACKGROUND: Neoadjuvant chemotherapy (NAC) has become an essential treatment for breast cancer. However, there is still no consensus on the best tool to evaluate pathological response to NAC. METHODS: Two reviewers systematically searched Cochrane, PubMed, EMBASE, Web of Science, and CBM (last updated in February 2017) for eligible articles. We independently screened and selected studies that conformed to the inclusion criteria and extracted the requisite data. Pooled sensitivity, specificity, and the area under the SROC curve were calculated to estimate the diagnostic accuracy of magnetic resonance imaging (MRI) and positron emission computed tomography (PET/CT)...
May 11, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29730304/assessing-the-effectiveness-of-interventions-to-support-patient-decision-making-about-breast-reconstruction-a-systematic-review
#6
REVIEW
Nicole Paraskeva, Ella Guest, Helena Lewis-Smith, Diana Harcourt
BACKGROUND: Decision making about breast reconstruction (BR) following a diagnosis of breast cancer, Ductal Carcinoma in Situ (DCIS), or to reduce future breast cancer risk, is difficult and complex. This paper systematically reviews interventions aiming to support patients facing the option of BR, and assesses their effectiveness in improving a range of patient outcomes. METHODS: Ten databases were searched for articles published up to October 2017 that evaluated interventions to support patient decision making about BR within controlled trials...
May 3, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29723697/an-exploratory-radiomics-analysis-on-digital-breast-tomosynthesis-in-women-with-mammographically-negative-dense-breasts
#7
Alberto Stefano Tagliafico, Francesca Valdora, Giovanna Mariscotti, Maunela Durando, Jacopo Nori, Daniele La Forgia, Ilan Rosenberg, Francesca Caumo, Nicoletta Gandolfo, Nehmat Houssami, Massimo Calabrese
PURPOSE: To compare Digital Breast Tomosynthesis (DBT) for cancers and normal screens in women with dense breasts and negative mammography using a Radiomics approach. MATERIALS AND METHODS: A substudy (N = 40) of the 'Adjunct Screening With Tomosynthesis or Ultrasound in Women With Mammography-Negative Dense Breasts (ASTOUND)' trial was done based on 20 women who had DBT-detected, histology-proven, breast cancer and 20 controls matched for age and density. Using a Radiomics approach normal and pathological breast parenchyma were evaluated, and correlations among Radiomics features and clinical and prognostic parameters were investigated...
April 30, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29709729/smoking-and-fgfr2-rs2981582-variant-independently-modulate-male-breast-cancer-survival-a-population-based-study-in-tuscany-italy
#8
Ines Zanna, Valentina Silvestri, Domenico Palli, Alessandro Magrini, Piera Rizzolo, Calogero Saieva, Veronica Zelli, Benedetta Bendinelli, Vania Vezzosi, Virginia Valentini, Simonetta Bianchi, Laura Ottini, Giovanna Masala
AIM: Male breast cancer (MBC) is a rare disease and recommendations for its clinical management are often extrapolated from those for female breast cancer, even if breast cancer (BC) has different characteristics in the two sexes. The purpose of this study was to assess the influence of several individual characteristics including clinico-pathological, lifestyle and genetic factors on overall survival (OS) of a relatively large and well characterized population-based series of 166 MBCs enrolled in Tuscany...
April 27, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29709728/patterns-of-disease-progression-in-patients-with-local-and-metastatic-breast-cancer-as-evaluated-by-whole-body-magnetic-resonance-imaging
#9
Michael Kosmin, Anwar R Padhani, Heminder Sokhi, Toon Thijssen, Andreas Makris
BACKGROUND: Patterns of progressive disease (PD) in patients with local and metastatic sites of breast cancer are poorly described. Whole-body magnetic resonance imaging (WB-MRI) identifies PD earlier than CT. METHODS: Thirty-one patients receiving first-line systemic anti-cancer therapy (SACT) were studied. Data were obtained from original WB-MRI reports. RESULTS: First PD was reported at metastatic sites only in 77.4%, and at local and metastatic sites concurrently in 22...
April 27, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29698928/identifying-pathologic-complete-response-of-the-breast-after-neoadjuvant-systemic-therapy-with-ultrasound-guided-biopsy-to-eventually-omit-surgery-study-design-and-feasibility-of-the-micra-trial-minimally-invasive-complete-response-assessment
#10
M E M van der Noordaa, F H van Duijnhoven, C E Loo, E van Werkhoven, K K van de Vijver, T Wiersma, H A O Winter-Warnars, G S Sonke, M T F D Vrancken Peeters
PURPOSE: Improvements in neoadjuvant systemic therapy (NST) for breast cancer patients have led to increasing rates of pathologic complete response (pCR). The MICRA trial (NTR6120) aims at identifying pCR with post-NST biopsies. Here, we report the study design and feasibility. METHODS: The MICRA-trial is a multi-center prospective cohort study. Patients with a pre-NST placed marker and radiologic complete (rCR) or partial response on MRI after NST are eligible for inclusion...
April 23, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29698927/a-randomized-phase-ii-trial-of-trastuzumab-plus-capecitabine-versus-lapatinib-plus-capecitabine-in-patients-with-her2-positive-metastatic-breast-cancer-previously-treated-with-trastuzumab-and-taxanes-wjog6110b-eltop
#11
Toshimi Takano, Junji Tsurutani, Masato Takahashi, Takeharu Yamanaka, Kazuko Sakai, Yoshinori Ito, Junya Fukuoka, Hideharu Kimura, Hidetaka Kawabata, Kenji Tamura, Koji Matsumoto, Kenjiro Aogi, Kazuhiko Sato, Kazuto Nishio, Kazuhiko Nakagawa, Toshiaki Saeki
BACKGROUND: For human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) with progression on trastuzumab-based therapy, continuing trastuzumab beyond progression and switching to lapatinib combined with chemotherapy are both valid options. We conducted an open-label, randomized phase II trial to compare the efficacy of these strategies. PATIENTS AND METHODS: Women with HER2-positive MBC previously treated with trastuzumab and taxanes were randomly assigned to receive trastuzumab plus capecitabine (HX) or lapatinib plus capecitabine (LX)...
April 23, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29698926/outcomes-of-systemic-therapy-for-advanced-triple-negative-breast-cancer-a-single-centre-experience
#12
Nicolò Matteo Luca Battisti, David Okonji, Thubeena Manickavasagar, Kabir Mohammed, Mark Allen, Alistair Ring
BACKGROUND: Prognosis is worse for advanced triple-negative breast cancer (aTNBC) compared to other disease subtypes. Trials describe treatment outcomes in single specified lines of therapy; but few data describe treatment outcomes across the whole treatment pathway, which is critical in determining when patients should be referred for trials and to inform discussion. We evaluated treatment outcomes for aTNBC (overall response rate [ORR], median progression-free survival [mPFS] and median overall survival [mOS]) in patients treated largely outside of clinical trials...
April 23, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29698925/highly-significant-improvement-in-guideline-adherence-relapse-free-and-overall-survival-in-breast-cancer-patients-when-treated-at-certified-breast-cancer-centres-an-evaluation-of-8323-patients
#13
Rolf Kreienberg, Achim Wöckel, Manfred Wischnewsky
OBJECTIVES: Certified multi-disciplinary breast cancer centres (CBCs) have been established worldwide. Development of CBCs, guideline-adherent systemic therapy and surgical management should now show an impact on outcomes. This analysis aimed to investigate whether guideline adherence (GA) rates, relapse-free survival (RFS) and overall survival (OS) have significantly improved at CBCs compared to the pre-certification period. MATERIALS AND METHODS: 8323 patients with primary breast cancer were treated in 17 German CBCs, which had been certified between 2003 and 2007 [2003 (n = 1), 2004 (n = 6), 2005 (n = 3), 2006 (n = 6) and 2007 (n = 1)]...
April 23, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29679936/controversies-in-monitoring-metastatic-breast-cancer-during-systemic-treatment-results-of-a-gim-gruppo-italiano-mammella-survey
#14
Bonotto Marta, Basile Debora, Gerratana Lorenzo, Pelizzari Giacomo, Bartoletti Michele, Vitale Maria Grazia, Fanotto Valentina, Lisanti Camilla, Mansutti Mauro, Minisini Alessandro Marco, Aprile Giuseppe, De Laurentiis Michele, Montemurro Filippo, Del Mastro Lucia, Puglisi Fabio
BACKGROUND: The optimal strategy for monitoring metastatic breast cancer (M-MBC) is unclear. Nevertheless, M-MBC influences patient's quality of life and it affects the use of resources in terms of both drugs and diagnostic exam prescription. We aim to disclose oncologists' approach on M-MBC, identifying controversial areas. METHODS: An anonymous online survey was conducted among GIM members who, based on their on-field experience, shared their own method for M-MBC planning...
April 18, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29677569/validation-of-the-ajcc-8th-prognostic-system-for-breast-cancer-in-an-asian-healthcare-setting
#15
R X Wong, F Y Wong, John Lim, W X Lian, Y S Yap
AIMS: We aim to validate the AJCC 8th edition prognostic staging system for breast cancer in an Asian setting. METHODS: Clinico-pathologic information and cancer-specific survival (CSS) outcomes of 6287 stage I to III patients with invasive breast cancer who underwent upfront surgery at SingHealth institutions in Singapore from 2006 to 2014 were analyzed. Survival distributions for the different staging systems were estimated by the Kaplan-Meier method and compared using the log-rank tests...
April 17, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29677568/validation-of-the-cps-eg-and-neo-bioscore-staging-systems-after-preoperative-systemic-therapy-for-breast-cancer-in-a-single-center-in-china
#16
Ling Xu, Xuening Duan, Bin Zhou, Yinhua Liu, Jingming Ye, Zhaorui Liu, Chao Ma, Hong Zhang, Shuang Zhang, Lanbo Zhang, Jianxin Zhao, Yuanjia Cheng
BACKGROUND: Prognostic assessment after preoperative systemic therapy (PST) plays a vital role in determining treatment in breast cancer patients. Many researchers have sought to develop a system to quantitate residual tumor and its correlation with prognosis after PST. This retrospective study validated the CPS + EG staging system and Neo-Bioscore in a single center in China. METHODS: Data from patients with non-metastatic primary breast cancer who were treated with PST and surgery from Jan...
April 17, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29674221/physical-activity-levels-after-treatment-for-breast-cancer-two-year-follow-up
#17
An De Groef, Inge Geraerts, Heleen Demeyer, Elien Van der Gucht, Lore Dams, Carlijn de Kinkelder, Sanne Dukers-van Althuis, Marijke Van Kampen, Nele Devoogdt
OBJECTIVES: Breast cancer treatment can have a considerable large and prolonged impact on activity levels of breast cancer survivors. Therefore, the aim of the present study was to investigate the change in total physical activity level and occupational, sport and household activity levels of breast cancer survivors from preoperatively up to 24 months after breast cancer surgery. Additionally, predictive factors for this change were investigated. METHODS: Patients with primary breast cancer (n = 267) filled in the Flemish Physical Activity Computerized Questionnaire (FPACQ) before surgery and 1, 3, 6, 12 and 24 months after surgery...
April 16, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29674220/childbearing-across-borders-fertility-and-parenthood-attitudes-and-decisions-among-breast-cancer-survivors-in-usa-and-portugal
#18
Vânia Gonçalves, Janella Hudson, Maria Cristina Canavarro, Julie Morris, M Catherine Lee, Kristine A Donovan, Steven K Sutton, Susan T Vadaparampil, Gwendolyn P Quinn
OBJECTIVE: To compare fertility and childbearing attitudes and decisions of Portuguese and American female reproductive aged breast cancer survivors. METHODS: This was a cross-sectional study of 102 young breast cancer survivors (59 from Portugal and 43 from USA). Demographic, clinical and reproductive information were collected. Fertility and parenthood attitudes and decisions were assessed through a self-report questionnaire devised specifically for the study...
April 16, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29674010/one-step-intraoperative-radiotherapy-optimizes-conservative-treatment-of-breast-cancer-with-advantages-in-quality-of-life-and-work-resumption
#19
Luca Sorrentino, Susanna Fissi, Ilaria Meaglia, Daniela Bossi, Ottavia Caserini, Serena Mazzucchelli, Marta Truffi, Sara Albasini, Paola Tabarelli, Marco Liotta, Giovanni B Ivaldi, Fabio Corsi
BACKGROUND: Intraoperative radiotherapy (IORT) could be not-inferior to external beam radiotherapy (EBRT) in selected patients, but toxicities, self-perception of body image, quality of life, and resumption of work or daily activities have been poorly explored. The aim of the present study was to compare these outcomes between EBRT, IORT full-dose (IORT-f) and IORT boost (IORT-b). METHODS: 443 consecutive patients, candidates for breast-conserving surgery, were included: EBRT was performed in 220 patients (49...
April 16, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29665448/all-pure-flat-atypical-atypia-lesions-of-the-breast-diagnosed-using-percutaneous-vacuum-assisted-breast-biopsy-do-not-need-surgical-excision
#20
Lobna Ouldamer, Elodie Poisson, Flavie Arbion, Carole Bonneau, Anne Vildé, Gilles Body, Patrick Michenet
BACKGROUND: The purposes of this study were to evaluate the outcome of women with pure flat atypical atypia (FEA) diagnosed at vacuum-assisted breast biopsy (VABB) targeting microcalcifications and to determine whether clinical, radiological and pathologic parameters are able to predict which lesions will be upgraded to malignancy. MATERIALS: 2414 cases of consecutive VABB for microcalcifications using VA 8-, 10- or 11-Gauge stereotactically guided core biopsy performed between January 2005 and December 2011 from two french breast cancer centers were evaluated...
April 14, 2018: Breast: Official Journal of the European Society of Mastology
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