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Breast: Official Journal of the European Society of Mastology

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https://www.readbyqxmd.com/read/28432979/the-reality-of-economics-for-oncologists
#1
REVIEW
David Taylor
This article outlines the historical development of health economics and its present role in oncology related health technology assessments (HTAs). Despite concerns about the prices and immediate costs of new anticancer medicines for indications such as breast cancer overall spending on such treatments is affordable and offers long term value for money in countries such as the US, Canada and those of Western Europe. Oncologists wishing to protect the interests of current and future patients with both advanced and earlier stage cancers may be regarded as having a responsibility to understand the nature of health economic evaluations, and to be actively involved in decisions affecting access to current treatments and future levels of investment in incrementally improving therapies...
April 19, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28419909/reduction-in-advanced-breast-cancer-after-introduction-of-a-mammography-screening-program-in-tyrol-austria
#2
W Oberaigner, Sabine Geiger-Gritsch, M Edlinger, M Daniaux, R Knapp, M Hubalek, U Siebert, C Marth, W Buchberger
BACKGROUND: We analysed all female breast cancer (BC) cases in Tyrol/Austria regarding the shift in cancer characteristics, especially the shift in advanced BC, for the group exposed to screening as compared to the group unexposed to screening. METHODS: The analysis was based on all BC cases diagnosed in women aged 40-69 years, resident in Tyrol, and diagnosed between 2009 and 2013. The data were linked to the Tyrolean mammography screening programme database to classify BC cases as "exposed to screening" or "unexposed to screening"...
April 15, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28415013/the-effect-of-exercise-on-fatigue-and-physical-functioning-in-breast-cancer-patients-during-and-after-treatment-and-at-6-months-follow-up-a-meta-analysis
#3
REVIEW
L K Juvet, I Thune, I K Ø Elvsaas, E A Fors, S Lundgren, G Bertheussen, G Leivseth, L M Oldervoll
Breast cancer is the leading cause of cancer in women worldwide. Exercise interventions may improve physical and psychological factors during and after active breast cancer treatment. The aim of this systematic review was to assess the current knowledge regarding the efficacy of physical exercise with respect to fatigue and self-reported physical functioning. Systematic searches in Cochrane Library, Medline, Embase, Cinahl, PsycINFO, AMED and PEDro. After assessing the quality of the studies, we identified 25 randomized controlled trials that included 3418 breast cancer patients...
April 14, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28395234/reirradiation-for-locally-recurrent-breast-cancer
#4
REVIEW
Gustavo Nader Marta, Tarek Hijal, Heloisa de Andrade Carvalho
The aim of this study is to review the current status of reirradiation therapy (Re-RT) for locally recurrent breast cancer. The overall outcome of breast/chest wall Re-RT is difficult to assess because of the wide range of different treatments that a patient may have undergone and the patient's individual features. The local control and complete response rates were reported to be 43-96% and 41-71%, respectively. The combination of Re-RT and hyperthermia seems to be related to improved outcomes. Toxicity rates vary between studies, and Re-RT is generally well tolerated...
April 7, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28395233/the-effect-of-obesity-on-pathological-complete-response-and-survival-in-breast-cancer-patients-receiving-uncapped-doses-of-neoadjuvant-anthracycline-taxane-based-chemotherapy
#5
Alex Farr, Myriam Stolz, Lukas Baumann, Zsuzsanna Bago-Horvath, Elisabeth Oppolzer, Georg Pfeiler, Michael Seifert, Christian F Singer
PURPOSE: The effect of obesity in breast cancer patients undergoing neoadjuvant chemotherapy (NAC) remains controversial. The aim of this study was to determine the obesity-related effect on pathological complete response (pCR) and survival in women receiving full uncapped doses of NAC. METHODS: We retrospectively analyzed the data of all consecutive women who underwent anthracycline-taxane-based NAC for primary breast cancer between 2005 and 2015 at the Department of Obstetrics and Gynecology, Medical University of Vienna...
April 7, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28395232/laser-interstitial-thermotherapy-application-for-breast-surgery-current-situation-and-new-trends
#6
REVIEW
Yohan Kerbage, Nacim Betrouni, Pierre Collinet, Henri Azaïs, Serge Mordon, Anne-Sophie Dewalle-Vignion, Benjamin Merlot
While breast specialists debate on therapeutic de-escalation in breast cancer, the treatment of benign lesions is also discussed in relation to new percutaneous ablation techniques. The purpose of these innovations is to minimize potential morbidity. Laser Interstitial ThermoTherapy (LITT) is an option for the ablation of targeted nodules. This review evaluated the scientific publications investigating the LITT approach in malignant and benign breast disease. Three preclinical studies and eight clinical studies (2 studies including fibroadenomas and 6 studies including breast cancers) were reviewed...
April 7, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28384565/impact-of-hormonal-status-on-outcome-of-ductal-carcinoma-in-situ-treated-with-breast-conserving-surgery-plus-radiotherapy-long-term-experience-from-two-large-institutional-series
#7
Icro Meattini, Calogero Saieva, Paolo Bastiani, Francesca Martella, Giulio Francolini, Monica Lo Russo, Lisa Paoletti, Morena Doria, Isacco Desideri, Francesca Terziani, Carla De Luca Cardillo, Benedetta Bendinelli, Cinzia Ciabatti, Cristina Muntoni, Galliano Tinacci, Jacopo Nori, Herd Smith, Beniamino Brancato, Lorenzo Galli, Luis Jose Sanchez, Donato Casella, Marco Bernini, Lorenzo Orzalesi, Giulio Alberto Carta, Simonetta Bianchi, Francesca Rossi, Lorenzo Livi
BACKGROUND: Ductal carcinoma in situ (DCIS) is a heterogeneous disease, for which the best adjuvant treatment is still uncertain. Many attempts of risk-groups stratification have been made over time, developing prognostic scores to predict risk of local recurrence (LR) on the basis of features such as age, final surgical margins (FSM) status, grade, and tumor size. The aim of our analysis was to evaluate the patterns of recurrence from a two large-institutional retrospective series. PATIENTS AND METHODS: We collected data on 457 patients treated with BCS and adjuvant RT between 1990 and 2012...
April 3, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28384564/effect-of-acupuncture-on-aromatase-inhibitor-induced-arthralgia-in-patients-with-breast-cancer-a-meta-analysis-of-randomized-controlled-trials
#8
Lawrence Chen, Chao-Chun Lin, Tsai-Wei Huang, Yi-Chun Kuan, Yao-Hsien Huang, Hung-Chou Chen, Chun-Yu Kao, Chih-Ming Su, Ka-Wai Tam
PURPOSE: Aromatase inhibitor (AI)-induced arthralgia (AIA) is a common side effect that may lead to premature discontinuation of effective hormonal therapy in patients with breast cancer. Acupuncture may relieve joint pain in patients with AIA. We conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the effectiveness of acupuncture in pain relief in AIA. METHODS: The PubMed, Embase, Cochrane Library, and Scopus databases and the ClinicalTrials...
April 3, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28384563/neuropathic-pain-after-breast-cancer-treatment-and-its-impact-on-sleep-quality-one-year-after-cancer-diagnosis
#9
Filipa Fontes, Marta Gonçalves, Susana Pereira, Nuno Lunet
OBJECTIVES: Data regarding the impact of breast cancer treatment-related neuropathic pain (NP) on sleep quality are scarce. Therefore, we aimed to assess the impact of breast cancer treatment-related NP on patients' sleep quality, during the first year after cancer diagnosis. MATERIALS AND METHODS: A total of 501 breast cancer patients were followed prospectively. Incident NP was identified through systematic evaluations after treatments and one year after enrolment...
April 3, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28371644/smoking-and-survival-of-breast-cancer-patients-a-meta-analysis-of-cohort-studies
#10
REVIEW
Wenhou Duan, Suyun Li, Xin Meng, Yanxin Sun, Chongqi Jia
OBJECTIVES: Published articles reported controversial results about the association of breast cancer survival with smoking. Hence, a meta-analysis was performed to investigate this association. METHODS: A comprehensive search was performed to identify relevant cohort studies (up to May 31st, 2016). In the current smoking and former smoking v. never smoking analyses, the fixed- or random-effect model was selected based on the heterogeneity test among studies. And the heterogeneity was measured using Q test and I(2) statistic...
March 31, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28364669/suggestion-of-brca1-c-5339t-c-p-l1780p-variant-confer-from-unknown-significance-to-likely-pathogenic-based-on-clinical-evidence-in-korea
#11
Jai Min Ryu, Goeun Kang, Seok Jin Nam, Seok Won Kim, Jonghan Yu, Se Kyung Lee, Soo Youn Bae, Sungmin Park, Hyun-June Paik, Jong-Won Kim, Sung-Shin Park, Jeong Eon Lee, Sung-Won Kim
PURPOSE: We describe a rationale for the re-classification of the BRCA1 c.5539T>C (L1780P) variant using a clinical evidence. METHODS: A retrospective review was conducted to identify all patients with breast or ovarian cancer and the L1780P variant between 2002 and 2015 at a single institution. RESULTS: We identified the BRCA1/2 genetic mutation test results of 1223 breast cancer patients and 174 patients with ovarian cancer. Of the 160 BRCA 1/2 variant unknown significance, 16 (10...
March 29, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28363679/tumor-infiltrating-lymphocytes-in-early-breast-cancer
#12
Giancarlo Pruneri, Andrea Vingiani, Carsten Denkert
Immunoediting represents a complex and dynamic process involving cancer and immune system cells, composed by three intertwined phases: elimination, equilibrium and escape. A large number of immune cell subtypes are involved, each playing a peculiar role in interacting with cancer cells: cytotoxic CD8(+) T cells play a main role in cancer killing by inducing tumor cell death, while FOXP3+ T-regulatory cells represent an immune-inhibitory cell subtype. The evaluation of tumor infiltrating lymphocytes (TILs) in H&E routine samples has been shown to represent a reliable surrogate of the immune anti-tumor activity and a robust independent prognostic biomarker in breast cancer (BC) patients, especially in the Tripe Negative and HER2+ subtypes...
March 28, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28360014/concurrent-versus-sequential-adjuvant-chemo-endocrine-therapy-in-hormone-receptor-positive-early-stage-breast-cancer-patients-a-systematic-review-and-meta-analysis
#13
F Poggio, M Ceppi, M Lambertini, P Bruzzi, D Ugolini, C Bighin, A Levaggi, S Giraudi, A D'Alonzo, M Vaglica, E Blondeaux, M R Sertoli, P Pronzato, L Del Mastro
BACKGROUND: Although in clinical practice adjuvant chemotherapy (CT) and endocrine therapy (ET) are administered sequentially in patients with hormone-receptor positive breast cancer, the optimal timing, i.e. concurrent or sequential administration, of these treatments has been scarcely investigated. To better clarify this issue we conducted a systematic review and meta-analysis of randomized studies comparing these two modalities of administrations in terms of disease-free survival (DFS) and overall survival (OS)...
March 27, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28351000/targeted-superparamagnetic-nanoparticles-coated-with-2-deoxy-d-gloucose-and-doxorubicin-more-sensitize-breast-cancer-cells-to-ionizing-radiation
#14
Jalil Pirayesh Islamian, Milad Hatamian, Negar Abbasi Aval, Mohammad Reza Rashidi, Asghar Mesbahi, Mohammad Mohammadzadeh, Mohammad Asghari Jafarabadi
INTRODUCTION: Nanoparticles are promising as a new approach to enhance chemo- radiotherapy efficiency in breast cancer mainly via targeted therapy. MATERIALS & METHODS: SKBR3 and T47D breast cancer cells were treated with superparamagnetic mesoporous hydroxyapatite nanocomposites (SPmHANs)conjugated with 1 μM doxorubicin and 0.5 mM 2-Deoxy-d-Glucose and irradiated with 1 and 2 Gy gamma rays in vitro. The treatment toxicity and also the apoptosis/necrosis ratio were measured by MTT assay and also ELISA cell death detection PLUS, respectively...
March 25, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28347588/reply-to-h-ian-robins
#15
LETTER
Luis Ruano, Susana Pereira, Filipa Fontes, Mariana Ramalho, Nuno Lunet
No abstract text is available yet for this article.
March 24, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28327352/update-on-the-diagnosis-and-management-of-malignant-phyllodes-tumors-of-the-breast
#16
REVIEW
Matthew Strode, Thaer Khoury, Christopher Mangieri, Kazuaki Takabe
Malignant phyllodes tumors of the breast are a rare entity. They occur infrequently but most often in younger women in comparison to typical epithelial-based breast cancers. Treatment of these tumors is not without controversy and in this review we will present an update on the diagnosis and management of malignant phyllodes tumors of the breast.
March 16, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28288387/can-we-make-a-portrait-of-women-with-inoperable-locally-advanced-breast-cancer
#17
Giacomo Montagna, Andres R Schneeberger, Lorenzo Rossi, Gabriella Bianchi Micheli, Francesco Meani, Mauro Imperiali, Alessandra Spitale, Olivia Pagani
INTRODUCTION: Delay between clinical presentation and treatment of breast cancer (BC) can significantly impact mortality. We aimed at drawing a picture of women with locally advanced breast cancer (LABC) treated at our Breast Unit and at investigating factors associated with treatment delay. MATERIAL AND METHODS: A retrospective descriptive analysis, using a specific 28-item semi-structured questionnaire, was conducted in 67 patients diagnosed with T4 BC. RESULTS: Nearly a third of our patients had at least one known predisposing factor for LABC...
March 10, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28285890/cancer-related-cognitive-impairment-and-its-relation-to-ptsd
#18
LETTER
H Ian Robins, Laddie Johnson, Noelle LoConte, Kimberly Brandt
No abstract text is available yet for this article.
March 9, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28285236/efficacy-of-nepa-netupitant-palonosetron-across-multiple-cycles-of-chemotherapy-in-breast-cancer-patients-a-subanalysis-from-two-phase-iii-trials
#19
Hope S Rugo, Giorgia Rossi, Giada Rizzi, Matti Aapro
OBJECTIVES: Breast cancer (BC) patients represent a high-risk population for experiencing chemotherapy-induced nausea and vomiting (CINV), since they frequently receive highly emetogenic anthracycline-cyclophosphamide-based (AC) chemotherapy, and are often female and young, two predisposing risk factors for CINV. Guidelines recommend the combination of a neurokinin-1 receptor antagonist (NK1RA), 5-hydroxytryptamine-3 RA (5-HT3RA), and dexamethasone (DEX) for CINV prophylaxis in AC-treated patients...
March 9, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28284541/integration-of-psycho-oncology-through-the-whole-care-pathway-for-breast-cancer-patients-in-europe
#20
LETTER
L Neamţiu, S Deandrea, L Pylkkänen, C Freeman, J López-Alcalde, A Bramesfeld, Z Saz-Parkinson, A Ulutürk, D Lerda
No abstract text is available yet for this article.
March 8, 2017: Breast: Official Journal of the European Society of Mastology
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