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Breast: Official Journal of the European Society of Mastology

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https://www.readbyqxmd.com/read/29957557/the-impact-of-organized-breast-assessment-on-survival-by-stage-for-screened-women-diagnosed-with-invasive-breast-cancer
#1
Courtney R Smith, Anna M Chiarelli, Claire Mb Holloway, Lucia Mirea, Frances P O'Malley, Kristina M Blackmore, Anjali Pandya, Vicky Majpruz, Cathy Paroschy Harris, Ashley Hendry, Amanda Hey, Anat Kornecki, George Lougheed, Barbara-Anne Maier, Patricia Marchand, David McCready, Carol Rand, Simon Raphael, Roanne Segal-Nadler, Neelu Sehgal, Derek Muradali
PURPOSE: Since 1998, the Ontario Breast Screening Program (OBSP) has offered organized assessment through Breast Assessment Centres (BAC). This study compares survival between screened women diagnosed with breast cancer who have undergone assessment through a BAC and usual care (UC). METHODS: A retrospective design identified two concurrent cohorts of women aged 50 to 69 within the OBSP diagnosed with screen-detected invasive breast cancer at a BAC (n = 2010) and UC (n = 1844) between 2002 and 2010 and followed until 2016...
June 18, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29940498/the-value-of-3d-images-in-the-aesthetic-evaluation-of-breast-cancer-conservative-treatment-results-from-a-prospective-multicentric-clinical-trial
#2
Maria João Cardoso, Conny Vrieling, Jaime S Cardoso, Helder P Oliveira, Norman R Williams, J M Dixon
PURPOSE: BCCT.core (Breast Cancer Conservative Treatment. cosmetic results) is a software created for the objective evaluation of aesthetic result of breast cancer conservative treatment using a single patient frontal photography. The lack of volume information has been one criticism, as the use of 3D information might improve accuracy in aesthetic evaluation. In this study, we have evaluated the added value of 3D information to two methods of aesthetic evaluation: a panel of experts; and an augmented version of the computational model - BCCT...
June 18, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29913374/fluctuation-of-the-left-ventricular-ejection-fraction-in-patients-with-her2-positive-early-breast-cancer-treated-by-12-months-of-adjuvant-trastuzumab
#3
Quentin Jacquinot, Sophie Paget-Bailly, Pierre Fumoleau, Gilles Romieu, Jean Yves Pierga, Marc Espié, Alain Lortholary, Jean Marc Nabholtz, Celine Faure Mercier, Iris Pauporté, Julie Henriques, Xavier Pivot
BACKGROUND: Cardiac toxicity with a decrease of the left ventricular ejection fraction (LVEF) is the main side effect induced by trastuzumab. This study reports the fluctuation of LVEF over the 12 months of adjuvant trastuzumab in PHARE trial (NCT00381901). METHODS: LVEF assessment was performed every 3 months while patients received trastuzumab and after completion of treatment over the first 2 years and then every 6 months afterwards. The fluctuations of LVEF over time were described and a logistic regression model was performed investigating associated factors to LVEF perfect recovery at baseline value...
June 15, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29933179/transmission-of-breast-cancer-polygenic-risk-based-on-single-nucleotide-polymorphisms
#4
David G Cox, Pierre-Etienne Heudel, Julie Henry, Xavier Pivot
AIM: The goal of the present study was to further refine how polygenic risk scores may be used in a large population and to quantify the transmission of risk score through generations. METHODS: Allele frequencies from the 1000 Genomes data for 159 single nucleotide polymorphisms associated with breast cancer risk were used. A breast cancer risk score was calculated among 100,000 people. Choosing two "parents" and the alleles they transmit at random, 100,000 "daughters" were simulated...
June 14, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29906741/group-medical-consultations-gmcs-and-tablet-based-online-support-group-sessions-in-the-follow-up-of-breast-cancer-a-multicenter-randomized-controlled-trial
#5
Annemiek Visser, Judith B Prins, Lisette Jansen, Sandra A Radema, Margrethe S Schlooz, Thijs van Dalen, Hanneke W M van Laarhoven
OBJECTIVE: Group medical consultations (GMCs) provide individual medical visits in the presence of ≤7 peer-patients. In the follow-up of breast cancer, we evaluated the efficacy of a new type of blended care My-GMC, a GMC combined with a tablet-based online app, consisting of three online support group sessions (SGS) and additional information. METHODS: This randomized controlled trial compared the effect of My-GMC (n = 59) with one individual medical visit (n = 50) (care as usual)...
June 12, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29902718/impact-of-schizophrenia-and-related-disorders-on-mortality-from-breast-cancer-a-population-based-cohort-study-in-denmark-1995-2011
#6
Susanne Oksbjerg Dalton, Nis Palm Suppli, Marianne Ewertz, Niels Kroman, Luigi Grassi, Christoffer Johansen
OBJECTIVES: To investigate overall and breast cancer-specific mortality in early-stage breast cancer patients with and without schizophrenia or related disorders. METHODS: We used Danish national registers to identify all women with no prior history of cancer or organic mental disorders, who were diagnosed with early-stage breast cancer 1995-2011. Logistic regression models were used to calculate the odds ratios (ORs) for not being allocated to guideline treatment...
June 11, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29937231/reply-to-valid-assessment-of-women-s-satisfaction-with-breast-cancer-screening-programs
#7
LETTER
Silvia Deandrea, Minna Salakari, Luciana Neamţiu, Asli Ulutürk, Donata Lerda, Liisa Pylkkänen
No abstract text is available yet for this article.
June 7, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29933180/feasibility-and-oncological-safety-of-sentinel-node-biopsy-in-breast-cancer-patients-with-a-local-recurrence
#8
N Biglia, V E Bounous, M Gallo, L Fuso, L G Sgro, F Maggiorotto, R Ponzone
OBJECTIVES: To investigate the role and feasibility of sentinel lymph node biopsy (SLNB) in breast cancer patients with a local recurrence and no clinically positive axillary lymph nodes. MATERIALS AND METHODS: A total of 71 patients underwent SLNB for breast cancer recurrence. At first surgery, they had received SLNB (46.5%), axillary lymph node dissection (ALND) (36.6%) or no axillary surgery (16.9%). RESULTS: Lymphatic migration was successful in 53 out of 71 patients (74...
June 7, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29890463/hpv-infection-and-breast-cancer-results-of-a-microarray-approach
#9
Andriana Kouloura, Electra Nicolaidou, Ioannis Misitzis, Euaggelia Panotopoulou, Vasilios Smyrniotis, Giovanni Corso, Paolo Veroneci, Nikolaos Arkadopoulos
OBJECTIVES: Human papilloma virus (HPV) has been implicated in several types of epithelial cancer. The role of HPV in breast carcinogenesis has been a matter of debate fueled by conflicting reports in recent years. The aim of this study is to identify the prevalence of breast and cervical HPV infection in cancer patients by using a modern microarray approach. MATERIALS AND METHODS: In the present prospective study, 201 breast cancer patients were included. For each patient a detailed medical history was taken and during the operation, under sterile conditions, samples were collected, from the tumour, the healthy adjacent breast tissue and any positive sentinel lymph nodes...
June 4, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29803409/corrigendum-to-validated-tools-measuring-women-s-satisfaction-in-breast-cancer-screening-programmes-a-systematic-review-breast-39-2018-33-38
#10
Silvia Deandrea, Minna Salakari, Luciana Neamţiu, Asli Ulutürk, Donata Lerda, Liisa Pylkkänen
No abstract text is available yet for this article.
May 23, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29906740/diagnostic-challenges-in-clinical-radiological-and-histopathological-tests-regarding-papillomatous-lesions-of-the-breast
#11
Birgitte Bruun Rasmussen, Eva Balslev, Ib Jarle Christensen, Charlotte Lanng, Anne Bak, Hanne Galatius, Maj-Lis Møller Talman, Nahid Sharghi Someh, Ilse Vejborg, Mette Okholm
Papillomas of the female breast is a relatively frequent lesion, and the majority are benign when excised. However, some may host malignant or premalignant areas. Consequently, it is a worldwide accepted principle to excise the lesion whenever diagnosed. However, this leads to a large number of patients having an unnecessary operation. The present study was designed to investigate whether we could find clinical, radiological and pathological factors in the preoperative, diagnostic setting that could identify patients hosting a benign papilloma in order to avoid operation...
May 22, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29857282/development-and-pilot-testing-of-a-decision-aid-da-for-women-with-early-stage-breast-cancer-considering-contralateral-prophylactic-mastectomy
#12
B Ager, J Jansen, D Porter, K A Phillips, R Glassey, P Butow
OBJECTIVE: Describe the development, acceptability and feasibility of a Decision Aid (DA) for women with early-stage breast cancer (BC) at average contralateral breast cancer (CBC) risk considering contralateral prophylactic mastectomy (CPM). METHODS: The DA was developed using the International Patient Decision Aid Standards (IPDAS) and the Ottawa Decision Support Framework. It provides evidence-based information about CPM in a booklet format combining text, graphs and images of surgical options...
May 22, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29804045/factors-associated-with-the-increasing-trend-of-contralateral-prophylactic-mastectomy-among-patients-with-ductal-carcinoma-in-situ-analysis-of-surveillance-epidemiology-and-end-results-data
#13
Qiuting You, Kai Chen, Yudong Li, Jianguo Lai, Yichao Fang, Shiyu Shen, Yicheng Liu, Fengxi Su, Fengyan Yu
PURPOSE: Our study aimed to investigate the factors influencing trends of contralateral prophylactic mastectomy (CPM) among patients with unilateral ductal carcinoma in situ (DCIS). PATIENTS AND METHODS: We used the Surveillance, Epidemiology, and End Results (SEER) data to identify patients with unilateral DCIS diagnosed from 1998 to 2013. Patients were categorized as breast-conserving surgery (BCS), Unilateral Mastectomy and CPM group. Univariate and multivariate logistic regressions were applied to assess the factors associated with undergoing CPM among mastectomy patients...
May 22, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29800932/evaluation-of-tolerability-and-efficacy-of-incorporating-carboplatin-in-neoadjuvant-anthracycline-and-taxane-based-therapy-in-a-brca1-enriched-triple-negative-breast-cancer-cohort
#14
Tal Sella, Einav Nili Gal Yam, Keren Levanon, Tal Shapira Rotenberg, Moran Gadot, Iryna Kuchuk, Rinat Bernstein Molho, Amit Itai, Tami Mekel Modiano, Raya Gold, Bella Kaufman, Shani Paluch Shimon
PURPOSE: The addition of carboplatin (Cb) to neoadjuvant chemotherapy in triple-negative breast cancer (TNBC) has been demonstrated to improve pathologic complete response (pCR) at the expense of increased toxicity. We aimed to evaluate the effectiveness and tolerability of dose-dense anthracycline & cyclophosphamide (ddAC) followed by weekly paclitaxel (wT) in combination with weekly Cb. METHODS: Retrospective data was collected on patients with clinical stage I-III TNBC treated with neoadjuvant ddAC-wTCb (four cycles of ddA 60 mg/m2 and ddC 600 mg/m2 every 2 weeks followed by 12 cycles of wT 80 mg/m2 with Cb AUC 1...
May 22, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29783185/impact-of-body-mass-index-on-the-efficacy-of-endocrine-therapy-in-patients-with-metastatic-breast-cancer-a-retrospective-two-center-cohort-study
#15
Luwam Zewenghiel, Henrik Lindman, Antonis Valachis
BAKGROUND: The aim of this study was to investigate the impact of body mass index (BMI) on the efficacy of endocrine therapy in postmenopausal women with metastatic hormone receptor breast cancer (HR+BC) as well as to identify if the potential difference in efficacy was associated with Fulvestrant only or both aromatase inhibitors (AIs) and Fulvestrant. METHODS: A consecutive cohort of postmenopausal women with HR+metastatic breast cancer that have received endocrine therapy including Fulvestrant as a metastatic treatment strategy at the Departments of Oncology in Eskilstuna and Uppsala, Sweden, between 2008 and 2016 were identified...
May 18, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29772517/dynamics-of-the-hazard-for-distant-metastases-after-ipsilateral-breast-tumor-recurrence-according-to-estrogen-receptor-status-an-analysis-of-2851-patients
#16
Massimiliano Gennaro, Serena Di Cosimo, Ilaria Ardoino, Silvia Veneroni, Luigi Mariani, Roberto Agresti, Maria Grazia Daidone, Filippo de Braud, Giovanni Apolone, Elia Biganzoli, Romano Demicheli
BACKGROUND: Breast cancer (BC) patients with ipsilateral breast tumor recurrence (IBTR) are at high risk of developing distant metastases (DM). We aimed to evaluate the risk pattern of developing DM, with respect to the occurrence of IBTR, in a large series of patients homogeneously treated by conservative surgery (QUART) with a considerably long follow-up. METHODS: Piecewise exponential model was used to investigate DM dynamics conditioning on known prognostic factors and IBTR occurrence as time dependent covariate...
May 14, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29763858/the-oncologic-impact-of-hormone-replacement-therapy-in-premenopausal-breast-cancer-survivors-a-systematic-review
#17
REVIEW
Yimeng Wang, Naomi Lewin, Yazan Qaoud, A Nikoo Rajaee, Adena S Scheer
SYNOPSIS: This is the first systematic review to investigate the risk of recurrence in breast cancer survivors <50 years old who have used hormone replacement therapy (HRT). BACKGROUND: The risk of HRT in premenopausal breast cancer survivors is unclear. Due to the higher incidence of estrogen receptor negative tumours in women <50, the potential for HRT to promote breast cancer recurrence may differ from older age groups. METHODS: We performed a search of Medline, EMBASE and CINAHL through June 2016...
May 12, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29758504/patients-perspectives-and-experiences-concerning-barriers-to-accessing-information-about-bilateral-prophylactic-mastectomy
#18
Rachael Glassey, Moira O'Connor, Angela Ives, Christobel Saunders, kConFab Investigators, Sarah O'Sullivan, Sarah J Hardcastle
PURPOSE: To explore the barriers and experiences of accessing information for women who have received genetic risk assessment/testing results for breast cancer (BC) and are considering a bilateral prophylactic mastectomy (BPM) and, exploring participants' preferences concerning information and support needs. METHODS: A qualitative retrospective study guided by interpretative phenomenological analysis was utilised. Semi-structured interviews were conducted with forty-six women who were either considering BPM or had already undergone the surgery...
May 11, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29758503/mri-and-pet-ct-for-evaluation-of-the-pathological-response-to-neoadjuvant-chemotherapy-in-breast-cancer-a-systematic-review-and-meta-analysis
#19
REVIEW
Huimin Li, Liang Yao, Penghui Jin, Lidong Hu, Xiaofei Li, Tiankang Guo, Kehu Yang
BACKGROUND: Neoadjuvant chemotherapy (NAC) has become an essential treatment for breast cancer. However, there is still no consensus on the best tool to evaluate pathological response to NAC. METHODS: Two reviewers systematically searched Cochrane, PubMed, EMBASE, Web of Science, and CBM (last updated in February 2017) for eligible articles. We independently screened and selected studies that conformed to the inclusion criteria and extracted the requisite data. Pooled sensitivity, specificity, and the area under the SROC curve were calculated to estimate the diagnostic accuracy of magnetic resonance imaging (MRI) and positron emission computed tomography (PET/CT)...
May 11, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29730304/assessing-the-effectiveness-of-interventions-to-support-patient-decision-making-about-breast-reconstruction-a-systematic-review
#20
REVIEW
Nicole Paraskeva, Ella Guest, Helena Lewis-Smith, Diana Harcourt
BACKGROUND: Decision making about breast reconstruction (BR) following a diagnosis of breast cancer, Ductal Carcinoma in Situ (DCIS), or to reduce future breast cancer risk, is difficult and complex. This paper systematically reviews interventions aiming to support patients facing the option of BR, and assesses their effectiveness in improving a range of patient outcomes. METHODS: Ten databases were searched for articles published up to October 2017 that evaluated interventions to support patient decision making about BR within controlled trials...
May 3, 2018: Breast: Official Journal of the European Society of Mastology
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