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Statistical Methods in Medical Research

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https://www.readbyqxmd.com/read/30232928/optimal-designs-for-testing-hypothesis-in-multiarm-clinical-trials
#1
Alessandro Baldi Antognini, Marco Novelli, Maroussa Zagoraiou
The present paper deals with the problem of designing randomized multiarm clinical trials for treatment comparisons in order to achieve a suitable trade-off among inferential precision and ethical concerns. Although the large majority of the literature is focused on the estimation of the treatment effects, in particular for the case of two treatments with binary outcomes, the present paper takes into account the inferential goal of maximizing the power of statistical tests to detect correct conclusions about the treatment effects for normally response trials...
September 20, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/30232923/a-robust-and-powerful-test-for-case-control-genetic-association-study-on-x-chromosome
#2
Peng Wang, Si-Qi Xu, Bei-Qi Wang, Wing Kam Fung, Ji-Yuan Zhou
Hundreds of genome-wide association studies were conducted to map the disease genes on autosomes in human beings. It is known that many complex diseases are sex-determined and X chromosome is expected to play an important role. However, only a few single-nucleotide polymorphisms on X chromosome were found to be significantly associated with the diseases under study. On the other hand, to balance the genetic effect between two sexes, X chromosome inactivation occurs in most of X-linked genes by silencing one copy of two X chromosomes in females and dosage compensation is achieved...
September 20, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/30229703/penalized-multiple-inflated-values-selection-method-with-application-to-safer-data
#3
Qiuya Li, Geoffrey Kf Tso, Yichen Qin, Travis I Lovejoy, Timothy G Heckman, Yang Li
Expanding on the zero-inflated Poisson model, the multiple-inflated Poisson model is applied to analyze count data with multiple inflated values. The existing studies on the multiple-inflated Poisson model determined the inflated values by inspecting the histogram of count response and fitting the model with different combinations of inflated values, which leads to relatively complicated computations and may overlook some real inflated points. We address a two-stage inflated values selection method, which takes all values of count response as potential inflated values and adopts the adaptive lasso regularization on the mixing proportion of those values...
September 19, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/30229698/a-spatial-regression-model-for-the-disaggregation-of-areal-unit-based-data-to-high-resolution-grids-with-application-to-vaccination-coverage-mapping
#4
C E Utazi, J Thorley, V A Alegana, M J Ferrari, K Nilsen, S Takahashi, Cje Metcalf, J Lessler, A J Tatem
The growing demand for spatially detailed data to advance the Sustainable Development Goals agenda of 'leaving no one behind' has resulted in a shift in focus from aggregate national and province-based metrics to small areas and high-resolution grids in the health and development arena. Vaccination coverage is customarily measured through aggregate-level statistics, which mask fine-scale heterogeneities and 'coldspots' of low coverage. This paper develops a methodology for high-resolution mapping of vaccination coverage using areal data in settings where point-referenced survey data are inaccessible...
September 19, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/30229695/a-bayesian-adaptive-phase-ii-clinical-trial-design-accounting-for-spatial-variation
#5
Beibei Guo, Yong Zang
Conventional phase II clinical trials evaluate the treatment effects under the assumption of patient homogeneity. However, due to inter-patient heterogeneity, the effect of a treatment may differ remarkably among subgroups of patients. Besides patient's individual characteristics such as age, gender, and biomarker status, a substantial amount of this heterogeneity could be due to the spatial variation across geographic regions because of unmeasured or unknown spatially varying environmental and social exposures...
September 19, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/30203725/a-novel-approach-to-selecting-classification-types-for-time-dependent-covariates-in-the-marginal-analysis-of-longitudinal-data
#6
I-Chen Chen, Philip M Westgate
Generalized estimating equations are routinely utilized for the marginal analysis of longitudinal data. In order to obtain consistent regression parameter estimates, these estimating equations must be unbiased. However, when certain types of time-dependent covariates are presented, these equations can be biased unless the working independence structure is used. Unfortunately, regression parameter estimation can be very inefficient with this structure because not all valid moment conditions are incorporated within the corresponding equations...
September 11, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/30203723/robust-likelihood-inference-for-diagnostic-accuracy-measures-for-paired-organs
#7
Tsung-Shan Tsou
Paired data arise naturally in Ophthalmology where pairs of eyes undergo diagnostic tests to predict the presence of certain diseases. The common correlation model is popular for modeling the joint probabilities of responses from fellow eyes for inference about accuracy measures. One of the assumptions underlying the model is exchangeability of fellow eyes that stipulates the accuracy measures such as sensitivities/specificities of fellow eyes be equal. We propose a parametric robust likelihood approach to testing the equality of accuracy measures of fellow eyes without modeling correlation...
September 11, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/30203707/a-review-and-empirical-comparison-of-causal-inference-methods-for-clustered-observational-data-with-application-to-the-evaluation-of-the-effectiveness-of-medical-devices
#8
Guy Cafri, Wei Wang, Priscilla H Chan, Peter C Austin
Observational studies are commonplace in medicine. A frequent concern is confounding bias due to differences in patient characteristics across treatment groups, but other important issues include dependency among observations nested within clusters (e.g. patients clustered within physicians or surgeons) and confounding due to cluster characteristics (e.g. physician or surgeon experience or training). Given the frequency with which these issues arise in medical research, as well as their relative complexity, methods for the analysis of clustered observational data are reviewed...
September 11, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/30198417/testing-modified-zeros-for-poisson-regression-models
#9
Yi Tang, Wan Tang
Excessive zeros are common in practice and may cause overdispersion and invalidate inferences when fitting Poisson regression models. Zero-inflated Poisson regression models may be applied if there are inflated zeros; however, it is desirable to test if there are inflated zeros before such zero-inflated Poisson models are applied. Assuming a constant probability of being a structural zero in a zero-inflated Poisson regression model, the existence of the inflated zeros may be tested by testing whether the constant probability is zero...
September 10, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/30189796/eliminating-systematic-bias-from-case-crossover-designs
#10
Xiaoming Wang, Sukun Wang, Warren Kindzierski
Case-crossover designs have been widely applied to epidemiological and medical investigations of associations between short-term exposures and risk of acute adverse health events. Much effort has been made in literature on understanding source of confounding and reducing systematic bias by reference-select strategies. In this paper, we explored the nature of bias in the ambi-directional and time-stratified case-crossover designs via simulation using actual air pollution data from urban Edmonton, Alberta, Canada...
September 7, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/30189794/inference-for-the-treatment-effect-in-multiple-period-cluster-randomised-trials-when-random-effect-correlation-structure-is-misspecified
#11
Jessica Kasza, Andrew B Forbes
Multiple-period cluster randomised trials, such as stepped wedge or cluster cross-over trials, are being conducted with increasing frequency. In the design and analysis of these trials, it is necessary to specify the form of the within-cluster correlation structure, and a common assumption is that the correlation between the outcomes of any pair of subjects within a cluster is identical. More complex models that allow for correlations within a cluster to decay over time have recently been suggested. However, most software packages cannot fit these models...
September 7, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/30175683/measures-for-concordance-and-discordance-with-applications-in-disease-control-and-prevention
#12
Marc Aerts, Adelino Jc Juga, Niel Hens
Bivariate binary response data appear in many applications. Interest goes most often to a parameterization of the joint probabilities in terms of the marginal success probabilities in combination with a measure for association, most often being the odds ratio. Using, for example, the bivariate Dale model, these parameters can be modelled as function of covariates. But the odds ratio and other measures for association are not always measuring the (joint) characteristic of interest. Agreement, concordance, and synchrony are in general facets of the joint distribution distinct from association, and the odds ratio as in the bivariate Dale model can be replaced by such an alternative measure...
September 3, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/30156122/asymptotic-and-exact-interval-estimators-of-the-common-odds-ratio-under-the-sequential-parallel-comparison-design
#13
Kung-Jong Lui
When studying treatments for psychiatric or mental diseases in a placebo-controlled trial, we may consider use of the sequential parallel comparison design to reduce the number of patients needed through the reduction of the high placebo response rate. Under the assumption that the odds ratio of responses is constant between phases in the sequential parallel comparison design, we derive the conditional maximum likelihood estimator for the odds ratio. On the basis of the conditional likelihood, we further derive three asymptotic interval and an exact interval estimators for the odds ratio of responses...
August 29, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/30146938/sensitivity-analysis-for-non-monotone-missing-binary-data-in-longitudinal-studies-application-to-the-nida-collaborative-cocaine-treatment-study
#14
Garrett M Fitzmaurice, Stuart R Lipsitz, Roger D Weiss
Conventional approaches for handling missingness in substance use disorder trials commonly rely upon a single deterministic "worst value" imputation that posits a perfect relationship between missingness and drug use ("missing value = presumed drug use"); this yields biased estimates of treatment effects and their standard errors. Instead, deterministic imputations should be replaced by probabilistic versions that encode researchers prior beliefs that those with missing data are more likely to be using drugs at those occasions...
August 27, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/30146936/robust-identification-of-target-genes-and-outliers-in-triple-negative-breast-cancer-data
#15
Pieter Segaert, Marta B Lopes, Sandra Casimiro, Susana Vinga, Peter J Rousseeuw
Correct classification of breast cancer subtypes is of high importance as it directly affects the therapeutic options. We focus on triple-negative breast cancer which has the worst prognosis among breast cancer types. Using cutting edge methods from the field of robust statistics, we analyze Breast Invasive Carcinoma transcriptomic data publicly available from The Cancer Genome Atlas data portal. Our analysis identifies statistical outliers that may correspond to misdiagnosed patients. Furthermore, it is illustrated that classical statistical methods may fail to identify outliers due to their heavy influence, prompting the need for robust statistics...
August 27, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/30132375/asymptotic-variability-of-multilevel-multirater-kappa-coefficients
#16
Sophie Vanbelle
Agreement studies are of paramount importance in various scientific domains. When several observers classify objects on categorical scales, agreement can be quantified through multirater kappa coefficients. In most statistical packages, the standard error of these coefficients is only available under the null hypothesis that the coefficient is equal to zero, preventing the construction of confidence intervals in the general case. The aim of this paper is triple. First, simple analytic formulae for the standard error of multirater kappa coefficients will be given in the general case...
August 22, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/30132370/underestimation-of-treatment-effects-in-sequentially-monitored-clinical-trials-that-did-not-stop-early-for-benefit
#17
Ian C Marschner, I Manjula Schou
In recent years, there has been a prominent discussion in the literature about the potential for overestimation of the treatment effect when a clinical trial stops at an interim analysis due to the experimental treatment showing a benefit over the control. However, there has been much less attention paid to the converse issue, namely, that sequentially monitored clinical trials which did not stop early for benefit tend to underestimate the treatment effect. In meta-analyses of many studies, these two sources of bias will tend to balance each other to produce an unbiased estimate of the treatment effect...
August 22, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/30126324/methods-for-shortening-patient-reported-outcome-measures
#18
Daphna Harel, Murray Baron
Patient-reported outcome measures are widely used to assess patient experiences, well-being, and treatment response in clinical trials and cohort-based observational studies. However, patients may be asked to respond to many different measures in order to provide researchers and clinicians with a wide array of information regarding their experiences. Collecting such long and cumbersome patient-reported outcome measures may burden patients, increase research costs, and potentially reduce the quality of the data collected...
August 20, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/30126322/tournament-leave-pair-out-cross-validation-for-receiver-operating-characteristic-analysis
#19
Ileana Montoya Perez, Antti Airola, Peter J Boström, Ivan Jambor, Tapio Pahikkala
Receiver operating characteristic analysis is widely used for evaluating diagnostic systems. Recent studies have shown that estimating an area under receiver operating characteristic curve with standard cross-validation methods suffers from a large bias. The leave-pair-out cross-validation has been shown to correct this bias. However, while leave-pair-out produces an almost unbiased estimate of area under receiver operating characteristic curve, it does not provide a ranking of the data needed for plotting and analyzing the receiver operating characteristic curve...
August 20, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/30084297/analyzing-pre-post-randomized-studies-with-one-post-randomization-score-using-repeated-measures-and-ancova-models
#20
Fei Wan
The analysis of covariance (ANCOVA) or repeated measures (RM) models are often used to compare the treatment effect between different arms in pre-post randomized studies. ANCOVA adjusts the baseline score as a covariate in regression models. RM treats both the baseline and post-randomization scores as outcome variables. We aim to establish the underlying connections between ANCOVA and a constrained RM ("cRM"). We start with the interrelated concepts in a pre-post randomized designs: homogeneous vs...
August 7, 2018: Statistical Methods in Medical Research
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