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PharmacoEconomics

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https://www.readbyqxmd.com/read/28063084/methodological-issues-surrounding-the-use-of-baseline-health-related-quality-of-life-data-to-inform-trial-based-economic-evaluations-of-interventions-within-emergency-and-critical-care-settings-a-systematic-literature-review
#1
REVIEW
Melina Dritsaki, Felix Achana, James Mason, Stavros Petrou
BACKGROUND: Trial-based cost-utility analyses require health-related quality of life data that generate utility values in order to express health outcomes in terms of quality-adjusted life years (QALYs). Assessments of baseline health-related quality of life are problematic where trial participants are incapacitated or critically ill at the time of randomisation. This review aims to identify and critique methods for handling non-availability of baseline health-related quality of life data in trial-based cost-utility analyses within emergency and critical illness settings...
January 6, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28063083/can-mapping-algorithms-based-on-raw-scores-overestimate-qalys-gained-by-treatment-a-comparison-of-mappings-between-the-roland-morris-disability-questionnaire-and-the-eq-5d-3l-based-on-raw-and-differenced-score-data
#2
Jason Madan, Kamran A Khan, Stavros Petrou, Sarah E Lamb
INTRODUCTION: Mapping algorithms are increasingly being used to predict health-utility values based on responses or scores from non-preference-based measures, thereby informing economic evaluations. OBJECTIVES: We explored whether predictions in the EuroQol 5-dimension 3-level instrument (EQ-5D-3L) health-utility gains from mapping algorithms might differ if estimated using differenced versus raw scores, using the Roland-Morris Disability Questionnaire (RMQ), a widely used health status measure for low back pain, as an example...
January 6, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28039617/measuring-care-related-quality-of-life-of-caregivers-for-use-in-economic-evaluations-carerqol-tariffs-for-australia-germany-sweden-uk-and-us
#3
Renske J Hoefman, Job van Exel, Werner B F Brouwer
BACKGROUND: Informal care is often not included in economic evaluations in healthcare, while the impact of caregiving can be relevant for cost-effectiveness recommendations from a societal perspective. The impact of informal care can be measured and valued with the CarerQol instrument, which measures the impact of informal care on seven important burden dimensions (CarerQol-7D) and values this in terms of general quality of life (CarerQol-VAS). The CarerQol can be included at the effect side of multi-criteria analyses of patient interventions or in cost-effectiveness or utility analysis of interventions targeted at caregivers...
December 31, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/28039616/a-cost-effectiveness-analysis-of-nintedanib-in-idiopathic-pulmonary-fibrosis-in-the-uk
#4
C Rinciog, M Watkins, S Chang, T M Maher, C LeReun, D Esser, A Diamantopoulos
BACKGROUND: International guidelines recommend nintedanib (OFEV(®)) as an option for the treatment of idiopathic pulmonary fibrosis (IPF). OBJECTIVE: The objective of this study was to assess the cost effectiveness of nintedanib versus pirfenidone, N-acetylcysteine and best supportive care (BSC) for the treatment of IPF from a UK payer's perspective. METHODS: A Markov model was designed to capture the changes in the condition of adults with IPF...
December 31, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/28000158/a-systematic-review-and-critical-appraisal-of-economic-evaluations-of-pharmacological-interventions-for-people-with-bipolar-disorder
#5
REVIEW
Ifigeneia Mavranezouli, Joran Lokkerbol
BACKGROUND: Bipolar disorder (BD) is a chronic mood disorder that causes substantial psychological and financial burden. Various pharmacological treatments are effective in the management and prevention of acute episodes of BD. In an era of tighter healthcare budgets and a need for more efficient use of resources, several economic evaluations have evaluated the cost effectiveness of treatments for BD. OBJECTIVE: The aim of this study was to systematically review and appraise published economic evaluations of pharmacological interventions for BD...
December 20, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27975196/economic-studies-in-motor-neurone-disease-a-systematic-methodological-review
#6
REVIEW
Alan Moore, Carolyn A Young, Dyfrig A Hughes
BACKGROUND: Motor neurone disease (MND) is a devastating condition which greatly diminishes patients' quality of life and limits life expectancy. Health technology appraisals of future interventions in MND need robust data on costs and utilities. Existing economic evaluations have been noted to be limited and fraught with challenges. OBJECTIVE: The aim of this study was to identify and critique methodological aspects of all published economic evaluations, cost studies, and utility studies in MND...
December 14, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27943135/degarelix-for-treating-advanced-hormone-dependent-prostate-cancer-an-evidence-review-group-perspective-of-a-nice-single-technology-appraisal
#7
REVIEW
Lesley Uttley, Sophie Whyte, Timothy Gomersall, Shijie Ren, Ruth Wong, Duncan Chambers, Paul Tappenden
As part of its Single Technology Appraisal Process, the National Institute for Health and Care Excellence (NICE) invited the manufacturer of degarelix (Ferring Pharmaceuticals) to submit evidence for the clinical and cost effectiveness of degarelix for the treatment of advanced hormone-dependent prostate cancer. The School of Health and Related Research Technology Appraisal Group at the University of Sheffield was commissioned to act as the independent Evidence Review Group (ERG). The ERG produced a critical review of the evidence contained within the company's submission to NICE...
December 10, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27928760/cost-effectiveness-analysis-of-prophylaxis-treatment-strategies-to-reduce-the-incidence-of-febrile-neutropenia-in-patients-with-early-stage-breast-cancer-or-non-hodgkin-lymphoma
#8
Kelly Fust, Xiaoyan Li, Michael Maschio, Guillermo Villa, Anju Parthan, Richard Barron, Milton C Weinstein, Luc Somers, Caroline Hoefkens, Gary H Lyman
OBJECTIVE: The objective of this study was to evaluate the cost effectiveness of no prophylaxis, primary prophylaxis (PP), or secondary prophylaxis (SP) with granulocyte colony-stimulating factors (G-CSFs), i.e., pegfilgrastim, lipegfilgrastim, filgrastim (6- and 11-day), or lenograstim (6- and 11-day), to reduce the incidence of febrile neutropenia (FN) in patients with stage II breast cancer receiving TC (docetaxel, cyclophosphamide) and in patients with non-Hodgkin lymphoma (NHL) receiving R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) over a lifetime horizon from a Belgian payer perspective...
December 7, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27928759/benefits-challenges-and-potential-strategies-of-open-source-health-economic-models
#9
LETTER
William C N Dunlop, Nicola Mason, James Kenworthy, Ron L Akehurst
No abstract text is available yet for this article.
December 7, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27928758/mapping-chu9d-utility-scores-from-the-pedsql-tm-4-0-sf-15
#10
Christine Mpundu-Kaambwa, Gang Chen, Remo Russo, Katherine Stevens, Karin Dam Petersen, Julie Ratcliffe
BACKGROUND: The Pediatric Quality of Life Inventory™ 4.0 Short Form 15 Generic Core Scales (hereafter the PedsQL) and the Child Health Utility-9 Dimensions (CHU9D) are two generic instruments designed to measure health-related quality of life in children and adolescents in the general population and paediatric patient groups living with specific health conditions. Although the PedsQL is widely used among paediatric patient populations, presently it is not possible to directly use the scores from the instrument to calculate quality-adjusted life-years (QALYs) for application in economic evaluation because it produces summary scores which are not preference-based...
December 7, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27873226/is-dimension-order-important-when-valuing-health-states-using-discrete-choice-experiments-including-duration
#11
Brendan Mulhern, Richard Norman, Paula Lorgelly, Emily Lancsar, Julie Ratcliffe, John Brazier, Rosalie Viney
BACKGROUND: Discrete choice experiments with duration (DCETTO) can be used to estimate utility values for preference-based measures, such as the EQ-5D-5L. For self-completion, the health dimensions are presented in a standard order. However, for valuation, this may result in order effects. Thus, it is important to understand whether health state dimension ordering affects values. The aim of this study was to examine the importance of dimension ordering on DCE values using EQ-5D-5L. METHODS: A choice experiment presenting two health profiles and a third immediate death option was developed...
November 21, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27873225/how-consistent-is-the-relationship-between-improved-glucose-control-and-modelled-health-outcomes-for-people-with-type-2-diabetes-mellitus-%C3%A2-a-systematic-review
#12
REVIEW
Xinyang Hua, Thomas Wai-Chun Lung, Andrew Palmer, Lei Si, William H Herman, Philip Clarke
BACKGROUND: There are an increasing number of studies using simulation models to conduct cost-effectiveness analyses for type 2 diabetes mellitus. OBJECTIVE: To evaluate the relationship between improvements in glycosylated haemoglobin (HbA1c) and simulated health outcomes in type 2 diabetes cost-effectiveness studies. METHODS: A systematic review was conducted on MEDLINE and EMBASE to collect cost-effectiveness studies using type 2 diabetes simulation models that reported modelled health outcomes of blood glucose-related interventions in terms of quality-adjusted life-years (QALYs) or life expectancy (LE)...
November 21, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27858368/valuing-meta-health-effects-for-use-in-economic-evaluations-to-inform-reimbursement-decisions-a-review-of-the-evidence
#13
REVIEW
Richard De Abreu Lourenco, Marion Haas, Jane Hall, Rosalie Viney
OBJECTIVE: This review explores the evidence from the literature regarding how meta-health effects (effects other than health resulting from the consumption of health care) are valued for use in economic evaluations. METHODS: A systematic review of the published literature (the EMBASE, MEDLINE, PsycINFO, CINAHL, EconLit and SocINDEX databases were searched for publications in March 2016, plus manual searching) investigated the associations between study methods and the resulting values for meta-health effects estimated for use in economic evaluations...
November 17, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27848220/evolocumab-for-treating-primary-hypercholesterolaemia-and-mixed-dyslipidaemia-an-evidence-review-group-perspective-of-a-nice-single-technology-appraisal
#14
REVIEW
Christopher Carroll, Paul Tappenden, Rachid Rafia, Jean Hamilton, Duncan Chambers, Mark Clowes, Paul Durrington, Nadeem Qureshi, Anthony S Wierzbicki
As part of its Single Technology Appraisal (STA) process, the National Institute for Health and Care Excellence (NICE) invited the manufacturer of evolocumab (Amgen) to submit evidence on the clinical and cost effectiveness of evolocumab. The appraisal assessed evolocumab as monotherapy or in combination with a statin (HMG-CoA reductase inhibitor) with or without ezetimibe, or in combination with ezetimibe (without statin therapy), in adult patients with primary hypercholesterolaemia (which includes mixed dyslipidaemia), for whom statins do not provide optimal control of their low-density lipoprotein cholesterol (LDL-C) levels and/or for whom statins are contraindicated or not tolerated...
November 16, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27848219/the-valuation-of-informal-care-in-cost-of-illness-studies-a-systematic-review
#15
REVIEW
Juan Oliva-Moreno, Marta Trapero-Bertran, Luz Maria Peña-Longobardo, Raúl Del Pozo-Rubio
BACKGROUND: There is a growing interest in incorporating informal care in cost-of-illness studies as a relevant part of the economic impact of some diseases. OBJECTIVE: The aim of this paper was to review the recent literature valuating the costs of informal care in a group of selected diseases from 2005 to 2015. METHODS: We carried out a systematic review on the economic impact of informal care, focusing on six selected diseases: arthritis or osteoarthritis, cancer, dementia, mental diseases, multiple sclerosis and stroke...
November 15, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27838913/validation-of-the-economic-and-health-outcomes-model-of-type-2-diabetes-mellitus-echo-t2dm
#16
Michael Willis, Pierre Johansen, Andreas Nilsson, Christian Asseburg
BACKGROUND: The Economic and Health Outcomes Model of Type 2 Diabetes Mellitus (ECHO-T2DM) was developed to address study questions pertaining to the cost-effectiveness of treatment alternatives in the care of patients with type 2 diabetes mellitus (T2DM). Naturally, the usefulness of a model is determined by the accuracy of its predictions. A previous version of ECHO-T2DM was validated against actual trial outcomes and the model predictions were generally accurate. However, there have been recent upgrades to the model, which modify model predictions and necessitate an update of the validation exercises...
November 12, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27838912/emergent-challenges-in-determining-costs-for-economic-evaluations
#17
Josephine C Jacobs, Paul G Barnett
This paper describes methods of determining costs for economic evaluations of healthcare and considers how cost determination is being affected by recent developments in healthcare. The literature was reviewed to identify the strengths and weaknesses of the four principal methods of cost determination: micro-costing, activity-based costing, charge-based costing, and gross costing. A scoping review was conducted to identify key trends in healthcare delivery and to identify costing issues associated with these changes...
November 12, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27832461/weighing-clinical-evidence-using-patient-preferences-an-application-of-probabilistic-multi-criteria-decision-analysis
#18
Henk Broekhuizen, Maarten J IJzerman, A Brett Hauber, Catharina G M Groothuis-Oudshoorn
The need for patient engagement has been recognized by regulatory agencies, but there is no consensus about how to operationalize this. One approach is the formal elicitation and use of patient preferences for weighing clinical outcomes. The aim of this study was to demonstrate how patient preferences can be used to weigh clinical outcomes when both preferences and clinical outcomes are uncertain by applying a probabilistic value-based multi-criteria decision analysis (MCDA) method. Probability distributions were used to model random variation and parameter uncertainty in preferences, and parameter uncertainty in clinical outcomes...
November 10, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27798809/a-review-of-us-drug-costs-relevant-to-medicare-medicaid-and-commercial-insurers-post-affordable-care-act-enactment-2010-2016
#19
REVIEW
Jacquelyn McRae, F Randy Vogenberg, Silky Webb Beaty, Elizabeth Mearns, Stefan Varga, Laura Pizzi
Since passage of the Affordable Care Act (ACA) in 2010, US stakeholders are increasingly being held accountable for the value of healthcare services and drugs administered to patients. Pharmacoeconomic analyses offer one method of demonstrating a product's value, yet there is a lack of resources specific to US drug costs relevant to each stakeholder. The aim of this study was to review current US drug costs (post-ACA). A literature review aimed at finding evidence on outpatient prescription drug costs was performed using the following sources: PubMed, governmental agencies, news websites, the Academy of Managed Care Pharmacy (AMCP) website, and Google Scholar...
October 31, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27798808/economic-evaluation-in-duchenne-muscular-dystrophy-model-frameworks-for-cost-effectiveness-analysis
#20
Erik Landfeldt, Lars Alfredsson, Volker Straub, Hanns Lochmüller, Katharine Bushby, Peter Lindgren
BACKGROUND: Several treatments are on the horizon for Duchenne muscular dystrophy (DMD), a terminal orphan disease. In many jurisdictions, decisions regarding pricing and reimbursement of these health technologies comprise evidence of value for money. OBJECTIVE: The objective of this study was to develop a cost-effectiveness model based on the Duchenne muscular dystrophy Functional Ability Self-Assessment Tool (DMDSAT), a new rating scale created specifically to measure disease progression in clinical practice and trials and model DMD in economic evaluations, and compare it with two alternative model structures...
October 31, 2016: PharmacoEconomics
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