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PharmacoEconomics

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https://www.readbyqxmd.com/read/30019118/medical-care-costs-associated-with-genital-warts-for-commercially-insured-us-patients
#1
Kristina R Dahlstrom, Shuangshuang Fu, Wenyaw Chan, Zeena Shelal, Lois M Ramondetta, David R Lairson
INTRODUCTION: Genital warts are caused by infection with human papillomavirus (HPV) and are associated with significant morbidity. Primary prevention of genital warts is possible through HPV vaccination, but vaccination rates remain low in the USA. When deciding to implement HPV vaccination programs, public health officials and policy makers rely on cost-effectiveness studies that accurately reflect costs associated with morbidity and mortality. However, previous information on the cost of treating genital warts was outdated...
July 18, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/30003435/the-future-of-precision-medicine-potential-impacts-for-health-technology-assessment
#2
James Love-Koh, Alison Peel, Juan Carlos Rejon-Parilla, Kate Ennis, Rosemary Lovett, Andrea Manca, Anastasia Chalkidou, Hannah Wood, Matthew Taylor
OBJECTIVE: Precision medicine allows healthcare interventions to be tailored to groups of patients based on their disease susceptibility, diagnostic or prognostic information, or treatment response. We analysed what developments are expected in precision medicine over the next decade and considered the implications for health technology assessment (HTA) agencies. METHODS: We performed a pragmatic literature search to account for the large size and wide scope of the precision medicine literature...
July 13, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29981004/economic-evaluation-for-the-uk-of-systemic-chemotherapies-as-first-line-treatment-of-metastatic-pancreatic-cancer
#3
Mahdi Gharaibeh, Ali McBride, David S Alberts, Brian Erstad, Marion Slack, Nimer Alsaid, J Lyle Bootman, Ivo Abraham
BACKGROUND: Gemcitabine (GEM), oxaliplatin plus GEM (OX + GEM), cisplatin plus GEM (CIS + GEM), capecitabine plus GEM (CAP + GEM), FOLFIRINOX (FFX), and nab-paclitaxel plus GEM (NAB-P + GEM) are the most commonly used regimens as first-line treatment of metastatic pancreatic cancer (MPC) in the UK. Independent economic evaluation of these regimens simultaneously has not been conducted for the UK. OBJECTIVE: Using data from a network meta-analysis as efficacy measures, we estimated the cost effectiveness and cost utility of these regimens for the UK...
July 6, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29971666/modeling-approaches-in-cost-effectiveness-analysis-of-disease-modifying-therapies-for-relapsing-remitting-multiple-sclerosis-an-updated-systematic-review-and-recommendations-for-future-economic-evaluations
#4
REVIEW
Luis Hernandez, Malinda O'Donnell, Maarten Postma
BACKGROUND: Numerous cost-effectiveness analyses (CEAs) of disease-modifying therapies (DMTs) for relapsing-remitting multiple sclerosis (RRMS) have been published in the last three decades. Literature reviews of the modeling methods and results from these CEAs have also been published. The last literature review that focused on modeling methods, without country or time horizon in the inclusion criteria, included studies published up to 2012. Since then, new DMTs have become available, and new models and data sources have been used to assess their cost effectiveness...
July 3, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29951793/ibrutinib-for-treating-waldenstr%C3%A3-m-s-macroglobulinaemia-an-evidence-review-group-perspective-of-a-nice-single-technology-appraisal
#5
REVIEW
Paul Tappenden, Christopher Carroll, John Stevens, Emma Simpson, Praveen Thokala, Ruth Wong, Josh Wright, Rebecca Auer
As part of its Single Technology Appraisal (STA) process, the UK National Institute for Health and Care Excellence (NICE) invited the manufacturer of ibrutinib (Janssen) to submit evidence on the clinical and cost effectiveness of ibrutinib for treating Waldenström's macroglobulinaemia (WM). The School of Health and Related Research Technology Assessment Group at the University of Sheffield was commissioned to act as the independent Evidence Review Group (ERG). The ERG produced a critical review of the evidence for the clinical and cost effectiveness of ibrutinib based on the company's submission to NICE...
June 27, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29926358/using-evidence-from-randomised-controlled-trials-in-economic-models-what-information-is-relevant-and-is-there-a-minimum-amount-of-sample-data-required-to-make-decisions
#6
John W Stevens
Evidence from randomised controlled trials (RCTs) is used to support regulatory approval and reimbursement decisions. I discuss how these decisions are typically made and argue that the amount of sample data and regulatory authorities' concerns over multiplicity are irrelevant when making reimbursement decisions. Decision analytic models (DAMs) are usually necessary to meet the requirements of an economic evaluation. DAMs involve inputs relating to health benefits and resource use that represent unknown true population parameters...
June 20, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29923128/comment-on-mapping-the-paediatric-quality-of-life-inventory-pedsql%C3%A2-generic-core-scales-onto-the-child-health-utility-index-9-dimension-chu-9d-score-for-economic-evaluation-in-children
#7
LETTER
https://www.readbyqxmd.com/read/29948965/costs-of-invasive-meningococcal-disease-a-global-systematic-review
#8
REVIEW
Bing Wang, Renee Santoreneos, Hossein Afzali, Lynne Giles, Helen Marshall
BACKGROUND: Invasive meningococcal disease remains a public health concern because of its rapid onset and significant risk of death and long-term disability. New meningococcal serogroup B and combination serogroup ACWY vaccines are being considered for publicly funded immunization programs in many countries. Contemporary costing data associated with invasive meningococcal disease are required to inform cost-effectiveness analyses. OBJECTIVE: The objective of this study was to estimate costs and resource utilization associated with acute infection and the long-term care of invasive meningococcal disease...
June 9, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29948964/economic-evaluation-for-usa-of-systemic-chemotherapies-as-first-line-treatment-of-metastatic-pancreatic-cancer
#9
Mahdi Gharaibeh, Ali McBride, David S Alberts, Marion Slack, Brian Erstad, Nimer Alsaid, J Lyle Bootman, Ivo Abraham
BACKGROUND: Treatments for metastatic pancreatic cancer include monotherapy with gemcitabine (GEM); combinations of GEM with oxaliplatin (OX + GEM), cisplatin (CIS + GEM), capecitabine (CAP + GEM), or nab-paclitaxel (NAB-P + GEM); and the non-GEM combination FOLFIRINOX. Combination therapies have yielded better survival outcomes than GEM alone. A sponsor-independent economic evaluation of these regimens has not been conducted for USA. OBJECTIVE: The objective of this study was to estimate the cost utility and cost effectiveness of these regimens from the payer perspective for USA...
June 9, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29882210/sarilumab-for-previously-treated-moderate-or-severe-rheumatoid-arthritis-an-evidence-review-group-perspective-of-a-nice-single-technology-appraisal
#10
REVIEW
Iñigo Bermejo, Shijie Ren, Emma Simpson, Mark Clowes, David L Scott, Adam Young, Matt Stevenson
As part of its single technology appraisal (STA) process, the National Institute for Health and Care Excellence (NICE) invited the manufacturer (Sanofi Genzyme) of sarilumab (SAR; Kevzara® ) to submit evidence of its clinical effectiveness and cost-effectiveness for previously treated moderate or severe rheumatoid arthritis (RA). The School of Health and Related Research Technology Appraisal Group at the University of Sheffield was commissioned to act as the independent Evidence Review Group (ERG). The ERG produced a detailed review of the evidence for the clinical effectiveness and cost-effectiveness of the technology, based upon the company's submission to NICE...
June 8, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29876877/should-low-and-middle-income-countries-adopt-clinical-guidelines-developed-in-rich-countries
#11
EDITORIAL
Alan Haycox
No abstract text is available yet for this article.
June 7, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29869050/cost-effectiveness-of-pharmacological-treatments-for-asthma-a-systematic-review
#12
REVIEW
Carlos E Rodriguez-Martinez, Monica P Sossa-Briceño, Jose A Castro-Rodriguez
OBJECTIVE: The objective of this article was to summarize the findings of all the available studies on alternative pharmacological treatments for asthma and assess their methodological quality, as well as to identify the main drivers of the cost effectiveness of pharmacological treatments for the disease. METHODS: A systematic review of the literature in seven electronic databases was conducted in order to identify all the available health economic evidence on alternative pharmacological treatments for asthma published up to April 2017...
June 4, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29785689/the-impact-of-hospital-costing-methods-on-cost-effectiveness-analysis-a-case-study
#13
José Leal, Stefania Manetti, James Buchanan
BACKGROUND: Several methods exist to cost hospital contacts when estimating the cost effectiveness of a new intervention. However, the implications of choosing a particular approach remain unclear. We compare the use of the three main diagnosis-related group (DRG)-based national unit costs in England to determine whether choice of approach can impact on economic evaluation results. METHODS: A cost-utility model was developed to compare secondary fracture prevention models of care for hip fracture patients, using data from large primary and hospital care administrative datasets in England...
May 22, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29777433/are-pcsk9-inhibitors-cost-effective
#14
Max J Korman, Kjetil Retterstøl, Ivar Sønbø Kristiansen, Torbjørn Wisløff
The objective of this study was to review available health economic evaluations of PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors. These drugs reduce low-density lipid cholesterol levels and cardiovascular risk, but their cost effectiveness has been questioned. We searched Medline and Embase for economic evaluations in any language at any time. Studies were included if they analysed any PCSK9 inhibitor compared with either statin alone or in combination with ezetimibe or any other therapy considered standard prior to the introduction of PCSK9 inhibitors...
May 18, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29761351/economic-evaluation-of-stiripentol-for-dravet-syndrome-a-cost-utility-analysis
#15
Jesse Elliott, Bláthnaid McCoy, Tammy Clifford, George A Wells, Doug Coyle
BACKGROUND: Dravet syndrome is a catastrophic form of pediatric treatment-resistant epilepsy with few effective treatment options. Stiripentol is approved for use in Canada for treatment of Dravet syndrome, but the associated long-term costs and benefits have not been well-studied and its cost effectiveness is unclear. OBJECTIVE: The aim of this study was to evaluate the cost effectiveness of stiripentol as an adjunctive treatment to clobazam and valproate for treatment of Dravet syndrome from the perspective of the Canadian public healthcare payer...
May 15, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29752675/estimating-drug-costs-how-do-manufacturer-net-prices-compare-with-other-common-us-price-references
#16
T Joseph Mattingly, Joseph F Levy, Julia F Slejko, Nneka C Onwudiwe, Eleanor M Perfetto
BACKGROUND: Drug costs are frequently estimated in economic analyses using wholesale acquisition cost (WAC), but what is the best approach to develop these estimates? Pharmaceutical manufacturers recently released transparency reports disclosing net price increases after accounting for rebates and other discounts. OBJECTIVE: Our objective was to determine whether manufacturer net prices (MNPs) could approximate the discounted prices observed by the U.S. Department of Veterans Affairs (VA)...
May 12, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29750430/a-practical-guide-to-conducting-a-systematic-review-and-meta-analysis-of-health-state-utility-values
#17
Stavros Petrou, Joseph Kwon, Jason Madan
Economic analysts are increasingly likely to rely on systematic reviews and meta-analyses of health state utility values to inform the parameter inputs of decision-analytic modelling-based economic evaluations. Beyond the context of economic evaluation, evidence from systematic reviews and meta-analyses of health state utility values can be used to inform broader health policy decisions. This paper provides practical guidance on how to conduct a systematic review and meta-analysis of health state utility values...
May 10, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29744795/correction-to-3l-5l-what-the-l-a-nice-conundrum
#18
Nancy Devlin, John Brazier, A Simon Pickard, Elly Stolk
The article 3L, 5L, What the L? A NICE Conundrum Written by Nancy Devlin, John Brazier, A. Simon Pickard, Elly Stolk was originally published electronically on the publisher's internet portal (currently Springer Link) on (26th February, 2018) without open access.
May 10, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29737464/highly-priced-gene-therapies-a-wake-up-call-for-early-price-regulation
#19
LETTER
Feng Xie
No abstract text is available yet for this article.
May 8, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29736895/cost-effectiveness-of-biological-asthma-treatments-a-systematic-review-and-recommendations-for-future-economic-evaluations
#20
REVIEW
R Brett McQueen, Danielle N Sheehan, Melanie D Whittington, Job F M van Boven, Jonathan D Campbell
BACKGROUND: Recently developed asthma biological therapies have been shown to provide relief for severe asthma patients not controlled by inhaled treatment. Given the relatively high costs of biological therapies, cost-effectiveness analyses (CEAs) may be required as a prerequisite for coverage and reimbursement. OBJECTIVE: We aimed to systematically review published literature on the economic impact of biological asthma therapies and to identify key drivers that impact cost-effectiveness in order to provide recommendations for future economic evaluations...
May 8, 2018: PharmacoEconomics
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