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Faraday Discussions

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https://www.readbyqxmd.com/read/29620133/light-induced-charge-and-energy-transport-in-nucleic-acids-and-proteins-general-discussion
#1
Amitabha Chattopadhyay, Richard Cogdell, Carlos E Crespo-Hernández, Ankona Datta, Arijit De, Stefan Haacke, Mahesh Hariharan, John Helliwell, Ashley Hughes, Roberto Improta, Mike Jones, Joshy Joseph, Tolga Karsili, Bern Kohler, Retheesh Krishnan, Anvy Kuriakose, Mahil L, Dimitra Markovitsi, Himani Medhi, Ganga Periyasamy, P I Pradeepkumar, Priyadarshi Roy Chowdhury, Manas Sarangi, Igor Schapiro, Gebhard F X Schertler, Ilme Schlichting, Javier Segarra-Martí, Rajaram Swaminathan, Vishnu V, Rienk van Grondelle, Ravi Kumar Venkatraman, Ravindra Venkatramani, Anthony Watts
No abstract text is available yet for this article.
April 5, 2018: Faraday Discussions
https://www.readbyqxmd.com/read/29617022/photocrosslinking-between-nucleic-acids-and-proteins-general-discussion
#2
Vinayak Bhat, Richard Cogdell, Carlos E Crespo-Hernández, Ankona Datta, Arijit De, Stefan Haacke, John Helliwell, Roberto Improta, Joshy Joseph, Tolga Karsili, Bern Kohler, Retheesh Krishnan, Mahil L, Frederick Lewis, Imon Mandal, Dimitra Markovitsi, Padmaja P Mishra, Sneha Paul, Ganga Periyasamy, P I Pradeepkumar, Priyadarshi Roy Chowdhury, Manas Sarangi, Devika Sasikumar, Igor Schapiro, Gebhard F X Schertler, Ilme Schlichting, Javier Segarra-Martí, Rajaram Swaminathan, Vishnu V, Rienk van Grondelle, Reji Varghese, Ravindra Venkatramani
No abstract text is available yet for this article.
April 4, 2018: Faraday Discussions
https://www.readbyqxmd.com/read/29617021/bionanophotonics-general-discussion
#3
Amitava Chandra, Amitabha Chattopadhyay, Richard Cogdell, Ankona Datta, Arijit De, Shaina Dhamija, Murali Golla, Stefan Haacke, Mahesh Hariharan, John Helliwell, Roberto Improta, Ramapurath S Jayasree, Mike Jones, Joshy Joseph, Tolga Karsili, Bern Kohler, Retheesh Krishnan, Imon Mandal, Dimitra Markovitsi, Himani Medhi, Padmaja P Mishra, Priyadarshi Roy Chowdhury, Manas Sarangi, Ilme Schlichting, John Seddon, Amit Sharma, Atchimnaidu Siriki, Rajaram Swaminathan, Rienk van Grondelle, Reji Varghese, Ravindra Venkatramani, Anthony Watts
No abstract text is available yet for this article.
April 4, 2018: Faraday Discussions
https://www.readbyqxmd.com/read/29617016/light-induced-damage-and-repair-in-nucleic-acids-and-proteins-general-discussion
#4
Amitava Chandra, Richard Cogdell, Carlos E Crespo-Hernández, Ankona Datta, Angelo Giussani, Stefan Haacke, John Helliwell, Roberto Improta, Ramapurath S Jayasree, Mike Jones, Tolga Karsili, Bern Kohler, Mahil L, Imon Mandal, Dimitra Markovitsi, Himani Medhi, Padmaja P Mishra, P I Pradeepkumar, Priyadarshi Roy Chowdhury, Manas Sarangi, Igor Schapiro, Ilme Schlichting, Javier Segarra-Martí, Amit Sharma, Vishnu V, Rienk van Grondelle, Anthony Watts
No abstract text is available yet for this article.
April 4, 2018: Faraday Discussions
https://www.readbyqxmd.com/read/29583144/spiers-memorial-lecture-introductory-lecture-the-impact-of-structure-on-photoinduced-processes-in-nucleic-acids-and-proteins
#5
Tatiana Domratcheva, Ilme Schlichting
Light is an important environmental variable and most organisms have evolved means to sense, exploit or avoid it and to repair detrimental effects on their genome. In general, light absorption is the task of specific chromophores, however other biomolecules such as oligonucleotides also do so which can result in undesired outcomes such as mutations and cancer. Given the biological importance of light-induced processes and applications for imaging, optogenetics, photodynamic therapy or photovoltaics, there is a great interest in understanding the detailed molecular mechanisms of photoinduced processes in proteins and nucleic acids...
March 27, 2018: Faraday Discussions
https://www.readbyqxmd.com/read/29564457/photoinduced-processes-in-nucleic-acids-and-proteins-concluding-remarks
#6
Rienk van Grondelle
Light induced charge and energy transport in nucleic acids and proteins is the basis of fundamental biological processes such as photosynthesis, vision, DNA-photostability, DNA-photodamage and photosensing. This article summarises the concluding remarks given at the Faraday Discussions meeting on this topic. The specific themes arising from the meeting that are discussed herein include charge transfer in nucleic acids and proteins, excited state dynamics and topology, vibrations and dynamic disorder, proteins and charge transfer states, nanobiophotonics coupled to biomedical applications and photosynthesis...
March 22, 2018: Faraday Discussions
https://www.readbyqxmd.com/read/29652068/poster-list
#7
(no author information available yet)
No abstract text is available yet for this article.
April 17, 2018: Faraday Discussions
https://www.readbyqxmd.com/read/29410984/the-role-of-water-molecules-in-phototransduction-of-retinal-proteins-and-g-protein-coupled-receptors
#8
Elena Lesca, Valérie Panneels, Gebhard F X Schertler
G protein coupled receptors (GPCRs) are a key family of membrane proteins in all eukaryotes and also very important drug targets for medical intervention. The extensively studied visual pigment rhodopsin is a prime example of a family A GPCR. Its chromophore ligand retinal is covalently linked to a lysine in helix seven forming a protonated Schiff base. Interestingly, this is the same situation in other-non-GPCR-retinal proteins, like the prototype light-driven microbial proton pump bacteriorhodopsin, albeit there is no (or only a very remote) phylogenetical link...
April 17, 2018: Faraday Discussions
https://www.readbyqxmd.com/read/29393940/a-qm-mm-study-of-the-initial-excited-state-dynamics-of-green-absorbing-proteorhodopsin
#9
Veniamin A Borin, Christian Wiebeler, Igor Schapiro
The primary photochemical reaction of the green-absorbing proteorhodopsin is studied by means of a hybrid quantum mechanics/molecular mechanics (QM/MM) approach. The simulations are based on a homology model derived from the blue-absorbing proteorhodopsin crystal structure. The geometry of retinal and the surrounding sidechains in the protein binding pocket were optimized using the QM/MM method. Starting from this geometry the isomerization was studied with a relaxed scan along the C13[double bond, length as m-dash]C14 dihedral...
April 17, 2018: Faraday Discussions
https://www.readbyqxmd.com/read/29388996/effect-of-point-mutations-on-the-ultrafast-photo-isomerization-of-anabaena-sensory-rhodopsin
#10
D Agathangelou, Y Orozco-Gonzalez, M Del Carmen Marín, P P Roy, J Brazard, H Kandori, K-H Jung, J Léonard, T Buckup, N Ferré, M Olivucci, S Haacke
Anabaena sensory rhodopsin (ASR) is a particular microbial retinal protein for which light-adaptation leads to the ability to bind both the all-trans, 15-anti (AT) and the 13-cis, 15-syn (13C) isomers of the protonated Schiff base of retinal (PSBR). In the context of obtaining insight into the mechanisms by which retinal proteins catalyse the PSBR photo-isomerization reaction, ASR is a model system allowing to study, within the same protein, the protein-PSBR interactions for two different PSBR conformers at the same time...
April 17, 2018: Faraday Discussions
https://www.readbyqxmd.com/read/29383368/direct-observation-of-the-external-force-mediated-conformational-dynamics-of-an-ihf-bound-holliday-junction
#11
Subhas C Bera, Tapas Paul, A N Sekar Iyengar, Padmaja P Mishra
We have investigated the isomerization dynamics and plausible energy landscape of 4-way Holliday junctions (4WHJs) bound to integration host factor (IHF, a DNA binding protein), considering the effect of applied external force, by single-molecule FRET methods. A slowing down of the forward as well as the backward rates of the isomerization process of the protein bound 4WHJ has been observed under the influence of an external force, which indicates an imposed restriction on the conformational switching. This has also been reflected by an increase in rigidity, as observed from the increase in the single-molecule FRET (smFRET)-anisotropy values (0...
April 17, 2018: Faraday Discussions
https://www.readbyqxmd.com/read/29383346/excited-state-dynamics-of-mononucleotides-and-dna-strands-in-a-deep-eutectic-solvent
#12
Yuyuan Zhang, Kimberly de La Harpe, Mahesh Hariharan, Bern Kohler
The photophysics of several mono- and oligonucleotides were investigated in a deep eutectic solvent for the first time. The solvent glyceline, prepared as a 1 : 2 mole ratio mixture of choline chloride and glycerol, was used to study excited-state deactivation in a non-aqueous solvent by the use of steady-state and time-resolved spectroscopy. DNA strands in glyceline retain the secondary structures that are present in aqueous solution to some degree, thus enabling a study of the effects of solvent properties on the excited states of stacked bases and stacked base pairs...
April 17, 2018: Faraday Discussions
https://www.readbyqxmd.com/read/29380840/probing-the-excited-state-dynamics-of-venus-origin-of-dual-emission-in-fluorescent-proteins
#13
Shaina Dhamija, Bhisham Thakur, Purnananda Guptasarma, Arijit K De
Fluorescent proteins exhibit interesting excited state photochemistry, leading to bright fluorescence emission that renders their versatile biological role and wide use as biomarkers. A molecular-level mechanism of the excited state dynamics is desirable to pinpoint the origin of the bright fluorescence of these proteins. Here we present studies on a yellow fluorescent protein variant, Venus, and investigate the photophysics behind the dual fluorescence emission upon UV excitation. Based on our studies, we propose that the unique nature of the potential energy surface is responsible for the observation of minor fluorescence in Venus which is not seen in wild type GFP...
April 17, 2018: Faraday Discussions
https://www.readbyqxmd.com/read/29372211/adenine-radicals-generated-in-alternating-at-duplexes-by-direct-absorption-of-low-energy-uv-radiation
#14
Akos Banyasz, Tiia Ketola, Lara Martínez-Fernández, Roberto Improta, Dimitra Markovitsi
There is increasing evidence that the direct absorption of photons with energies that are lower than the ionization potential of nucleobases may result in oxidative damage to DNA. The present work, which combines nanosecond transient absorption spectroscopy and quantum mechanical calculations, studies this process in alternating adenine-thymine duplexes (AT)n. We show that the one-photon ionization quantum yield of (AT)10 at 266 nm (4.66 eV) is (1.5 ± 0.3) × 10-3. According to our PCM/TD-DFT calculations carried out on model duplexes composed of two base pairs, (AT)1 and (TA)1, simultaneous base pairing and stacking does not induce important changes in the absorption spectra of the adenine radical cation and deprotonated radical...
April 17, 2018: Faraday Discussions
https://www.readbyqxmd.com/read/29372193/photochemical-relaxation-pathways-of-s-6-methylthioinosine-and-o-6-methylguanosine-in-solution
#15
Brennan Ashwood, Luis A Ortiz-Rodríguez, Carlos E Crespo-Hernández
S6-Methylthioinosine and O6-methylguanosine are byproducts resulting from the enzymatic reactions of sulfur-substituted prodrugs in cells and from the interaction of alkylating agents with cellular DNA, respectively. Their photochemistry has not been investigated, and it is currently unknown whether light absorption by these byproducts may pose any threat to the cell. In this contribution, their photoinduced processes upon absorption of UVB radiation are reported using broadband transient absorption spectroscopy...
April 17, 2018: Faraday Discussions
https://www.readbyqxmd.com/read/29364305/engineered-photoproteins-that-give-rise-to-photosynthetically-incompetent-bacteria-are-effective-as-photovoltaic-materials-for-biohybrid-photoelectrochemical-cells
#16
Juntai Liu, Vincent M Friebe, David J K Swainsbury, Lucy I Crouch, David A Szabo, Raoul N Frese, Michael R Jones
Reaction centre/light harvesting proteins such as the RCLH1X complex from Rhodobacter sphaeroides carry out highly quantum-efficient conversion of solar energy through ultrafast energy transfer and charge separation, and these pigment-proteins have been incorporated into biohybrid photoelectrochemical cells for a variety of applications. In this work we demonstrate that, despite not being able to support normal photosynthetic growth of Rhodobacter sphaeroides, an engineered variant of this RCLH1X complex lacking the PufX protein and with an enlarged light harvesting antenna is unimpaired in its capacity for photocurrent generation in two types of bio-photoelectrochemical cells...
April 17, 2018: Faraday Discussions
https://www.readbyqxmd.com/read/29364301/mechanistic-insights-into-photoinduced-damage-of-dna-and-rna-nucleobases-in-the-gas-phase-and-in-bulk-solution
#17
Pratip Chakraborty, Tolga N V Karsili, Barbara Marchetti, Spiridoula Matsika
DNA/RNA photohydrates represent a class of well-known biomolecular lesions formed by the absorption of near- to mid-UV light. They are formed via a photoinduced nucleophilic hydrolysis reaction in which water is split (via nucleobase sensitisation) into H + OH radicals. These nascent radicals can then add across C5[double bond, length as m-dash]C6, saturating the preexisting double bond. If unrepaired, such lesions can lead to mutagenic carcinogenesis, which is responsible for several forms of cancer. Using high-level electronic structure theory (CASPT2), we map the key excited-state reaction paths associated with the reactivity of DNA (guanine and thymine) and RNA (uracil) nucleobases with water...
April 17, 2018: Faraday Discussions
https://www.readbyqxmd.com/read/29363700/optically-sensing-phospholipid-induced-coil-helix-transitions-in-the-phosphoinositide-binding-motif-of-gelsolin
#18
Samsuzzoha Mondal, Amitava Chandra, Ravindra Venkatramani, Ankona Datta
We present a systematic experimental and computational study of phospholipid induced peptide coil-helix transitions which are relevant in the context of proteins mediating cytoskeletal rearrangement via membrane binding. We developed a sensitive Förster resonance energy transfer (FRET) based assay to address whether coil-helix transitions in phospholipid binding motifs of actin-binding proteins can be induced by physiologically-relevant concentrations (1-20 μM) of phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) phospholipids...
April 17, 2018: Faraday Discussions
https://www.readbyqxmd.com/read/29362761/protein-charge-transfer-absorption-spectra-an-intrinsic-probe-to-monitor-structural-and-oligomeric-transitions-in-proteins
#19
Mohd Ziauddin Ansari, Amrendra Kumar, Dileep Ahari, Anurag Priyadarshi, Padmavathi Lolla, Rashna Bhandari, Rajaram Swaminathan
Protein Charge Transfer Spectra (ProCharTS) originate when charged amino/carboxylate groups in the side chains of Lys/Glu act as electronic charge acceptors/donors for photoinduced charge transfer either from/to the polypeptide backbone or to each other. The absorption band intensities in ProCharTS at wavelengths of 250-800 nm are dependent on the 3D spatial proximity of these charged functional groups across the protein. Intrinsically disordered proteins (IDPs) are an important class of proteins involved in signalling and regulatory functions in the eukaryotic cell...
April 17, 2018: Faraday Discussions
https://www.readbyqxmd.com/read/29362748/fluorescent-excimers-and-exciplexes-of-the-purine-base-derivative-8-phenylethynyl-guanine-in-dna-hairpins
#20
Kristen E Brown, Arunoday P N Singh, Yi-Lin Wu, Lin Ma, Ashutosh K Mishra, Brian T Phelan, Ryan M Young, Frederick D Lewis, Michael R Wasielewski
The ground- and excited-state electronic interactions between the nucleobase analog 8-(4'-phenylethynyl)deoxyguanosine, EG, with natural nucleobases and 7-deazaguanine, as well as between adjacent EG base analogs, have been characterized using a combination of steady-state spectroscopy and time-resolved fluorescence, absorption, and stimulated Raman spectroscopies. The properties of the nucleoside EG-H2 are only weakly perturbed upon incorporation into synthetic DNA hairpins in which thymine, cytosine or adenine are the bases flanking EG...
April 17, 2018: Faraday Discussions
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