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European Child & Adolescent Psychiatry

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https://www.readbyqxmd.com/read/28822049/potential-for-diagnosis-versus-therapy-monitoring-of-attention-deficit-hyperactivity-disorder-a-new-epigenetic-biomarker-interacting-with-both-genotype-and-auto-immunity
#1
Walter Adriani, Emilia Romano, Mariangela Pucci, Esterina Pascale, Luca Cerniglia, Silvia Cimino, Renata Tambelli, Paolo Curatolo, Oleg Granstrem, Mauro Maccarrone, Giovanni Laviola, Claudio D'Addario
In view of the need for easily accessible biomarkers, we evaluated in ADHD children the epigenetic status of the 5'-untranslated region (UTR) in the SLC6A3 gene, coding for human dopamine transporter (DAT). We analysed buccal swabs and sera from 30 children who met DSM-IV-TR criteria for ADHD, assigned to treatment according to severity. Methylation levels at six-selected CpG sites (among which, a CGGCGGCGG and a CGCG motif), alone or in combination with serum titers in auto-antibodies against dopamine transporter (DAT aAbs), were analysed for correlation with CGAS scores (by clinicians) and Conners' scales (by parents), collected at recruitment and after 6 weeks...
August 18, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28821994/psychiatry-mental-health-mental-disability-time-for-some-necessary-clarifications
#2
EDITORIAL
Bruno Falissard, Marlène Monégat, Gordon Harper
No abstract text is available yet for this article.
August 18, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28808831/the-2017-escap-research-academy-workshop-bright-perspectives-for-child-and-adolescent-psychiatry
#3
Alexis Revet, Johannes Hebebrand, Paul Klauser
No abstract text is available yet for this article.
August 14, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28799094/hydrogen-breath-test-to-detect-small-intestinal-bacterial-overgrowth-a-prevalence-case-control-study-in-autism
#4
Li Wang, Yu-Mei Yu, You-Qi Zhang, Jie Zhang, Na Lu, Na Liu
The aim of this study is to assess the prevalence of small intestinal bacterial overgrowth (SIBO) by hydrogen breath test in patients with autism spectrum disorders (ASD) with respect to a consistent control group. From 2011 to 2013, 310 children with ASD and 1240 sex- and age-matched typical children were enrolled in this study to undergo glucose breath test. The study participants were considered to exhibit SIBO when an increase in H2 of ≥20 ppm or CH4 of ≥10 ppm with respect to the fasting value was observed up to 60 min after the ingestion of glucose...
August 10, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28791523/parent-dependent-stressors-and-the-onset-of-anxiety-disorders-in-children-links-with-parental-psychopathology
#5
Jennifer L Allen, Seija Sandberg, Celine Y Chhoa, Tom Fearn, Ronald M Rapee
Exposure to stressors is associated with an increased risk for child anxiety. Investigating the family origins of stressors may provide promising avenues for identifying and intervening with children at risk for the onset of anxiety disorders and their families. The aim of this study was to compare the frequency of parent-dependent negative life events and chronic adversities experienced by children with an anxiety disorder (n = 34) in the 12 months prior to the onset of the child's most recent episode, compared to healthy controls (n = 34)...
August 8, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28785852/breakdown-of-foster-care-placements-in-flanders-incidence-and-associated-factors
#6
Johan Vanderfaeillie, Frank Van Holen, Elke Carlier, Hanne Fransen
In Flanders, family foster care is increasingly the option of choice for children in need of out-of-home care. Foster care is however an assailable intervention as is shown by the high number of placement disruptions. Knowledge regarding breakdown in Flanders remains scant. This study aimed at investigating the incidence of placement breakdown in Flemish long-term foster care and exploring the association of breakdown with foster child, foster family and case characteristics. Case files of 309 Flemish foster children were analysed...
August 7, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28779358/self-injury-and-suicide-behavior-among-young-people-with-perceived-parental-alcohol-problems-in-denmark-a-school-based-survey
#7
Veronica S C Pisinger, Keith Hawton, Janne S Tolstrup
The aim of this study was to test the hypothesis that young people who perceive their parents to have alcohol problems are more likely to self-injure, have suicide ideation, and to attempt suicide than young people without parental alcohol problems. We also tested whether the association between parental alcohol problems and self-injury, suicide ideation, and suicide attempt among young people differed depending on the gender of the child and the parent. Data came from the Danish National Youth Study 2014, a web-based national survey...
August 4, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28776094/upper-secondary-school-students-compliance-with-two-internet-based-self-help-programmes-a-randomised-controlled-trial
#8
Carl Antonson, Frida Thorsén, Jan Sundquist, Kristina Sundquist
Psychiatric symptoms and stress are on the increase among Swedish adolescents. We aimed to study the potential effect and feasibility of two Internet-based self-help programmes, one mindfulness based (iMBI) and the other music based in a randomised controlled trial that targeted adolescents. A total of 283 upper secondary school students in two Swedish schools were randomised to either a waiting list or one of the two programmes, on their own incentive, on schooltime. General psychiatric health (Symptoms Checklist 90), sleep quality (Pittsburgh Sleep Quality Index), and perceived stress (Perceived Stress Scale) were assessed before and after the interventions...
August 3, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28761989/comparing-the-dimensional-structure-and-diagnostic-algorithms-between-dsm-5-and-icd-11-ptsd-in-children-and-adolescents
#9
Cedric Sachser, Lucy Berliner, Tonje Holt, Tine Jensen, Nathaniel Jungbluth, Elizabeth Risch, Rita Rosner, Lutz Goldbeck
In contrast to the DSM-5, which expanded the posttraumatic stress disorder (PTSD) symptom profile to 20 symptoms, a workgroup of the upcoming ICD-11 suggested a reduced symptom profile with six symptoms for PTSD. Therefore, the objective of the study was to investigate the dimensional structure of DSM-5 and ICD-11 PTSD in a clinical sample of trauma-exposed children and adolescents and to compare the diagnostic rates of PTSD between diagnostic systems. The study sample consisted of 475 self-reports and 424 caregiver-reports on the child and adolescent trauma screen (CATS), which were collected at pediatric mental health clinics in the US, Norway and Germany...
July 31, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28748485/early-onset-first-episode-psychosis-dimensional-structure-of-symptoms-clinical-subtypes-and-related-neurodevelopmental-markers
#10
Maria Giuseppina Petruzzelli, Lucia Margari, Andrea Bosco, Francesco Craig, Roberto Palumbi, Francesco Margari
Despite the growing interest in a dimensional approach to the assessment of symptoms and clinically relevant phenomena in schizophrenia spectrum disorders, very few studies, to date, have examined the dimensional structure of symptoms in early onset first episode psychosis. In the present study, we assessed a sample of 60 children and adolescents of both sexes with first episode schizophrenia spectrum psychosis. A principal component analysis (PCA) of the Positive and Negative Syndrome Scale (PANSS) was performed and the factors obtained were used to carry out a cluster analysis...
July 26, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28748484/assessing-for-suicidal-behavior-in-youth-using-the-achenbach-system-of-empirically-based-assessment
#11
Anna R Van Meter, Guillermo Perez Algorta, Eric A Youngstrom, Yana Lechtman, Jen K Youngstrom, Norah C Feeny, Robert L Findling
This study investigated the clinical utility of the Achenbach System of Empirically Based Assessment (ASEBA) for identifying youth at risk for suicide. Specifically, we investigated how well the Total Problems scores and the sum of two suicide-related items (#18 "Deliberately harms self or attempts suicide" and #91 "Talks about killing self") were able to distinguish youth with a history of suicidal behavior. Youth (N = 1117) aged 5-18 were recruited for two studies of mental illness. History of suicidal behavior was assessed by semi-structured interviews (K-SADS) with youth and caregivers...
July 26, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28744718/at-least-one-more-reason-why
#12
LETTER
Charles-Edouard Notredame, Pierre Grandgenèvre, Guillaume Vaiva, Monique Séguin
No abstract text is available yet for this article.
July 25, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28733915/characteristics-of-undiagnosed-children-with-parent-reported-adhd-behaviour
#13
Kathrine Bang Madsen, Mette Holmelin Ravn, Jon Arnfred, Jørn Olsen, Charlotte Ulrikka Rask, Carsten Obel
There is an ongoing public debate on the diagnosis of attention deficit hyperactivity disorder (ADHD) in which critics have claimed that the disorder is over-diagnosed, while the potential under-diagnosis of children with ADHD has received little attention. In this study we estimate the number of children with parent-reported ADHD behaviour at age 7 and absence of recorded ADHD diagnosis through adolescence, and investigate whether socio-demographic characteristics of this group differed from the children diagnosed with ADHD during follow-up...
July 21, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28712019/maternal-body-mass-index-before-pregnancy-as-a-risk-factor-for-adhd-and-autism-in-children
#14
Christina Hebsgaard Andersen, Per Hove Thomsen, Ellen Aagaard Nohr, Sanne Lemcke
The risk of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) may be influenced by environmental factors such as maternal obesity before pregnancy. Previous studies investigating those associations have found divergent results. We aim to investigate in a large birth cohort this association further in children with ADHD, ASD and comorbid ADHD and ASD. Our study population consisted of 81,892 mother-child pairs participating in the Danish National Birth Cohort (DNBC). Information about pre-pregnancy weight and height was collected in week 16 of pregnancy; the analysis was divided into groups based on BMI...
July 15, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28710695/serum-brain-derived-neurotrophic-factor-levels-in-treatment-na%C3%A3-ve-boys-with-attention-deficit-hyperactivity-disorder-treated-with-methylphenidate-an-8-week-observational-pretest-posttest-study
#15
Aynur Pekcanlar Akay, Halil Resmi, Sevay Alsen Güney, Handan Özek Erkuran, Gonca Özyurt, Enis Sargin, Ahmet Topuzoglu, Ali Evren Tufan
Brain-derived neurotrophic factor (BDNF) is an important neurotrophin in the brain that modulates dopaminergic neurons. In this study, we aimed to investigate the changes in serum BDNF levels of children with attention-deficit/hyperactivity disorder (ADHD) in response to OROS methylphenidate treatment. We also aimed to determine whether there were any pre-post-differences between ADHD subtypes and comorbid psychiatric disorders in serum BDNF levels. Fifty male children with ADHD and 50 male healthy controls within the age range of 6-12 years were recruited to the study...
July 14, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28707138/gray-matter-changes-and-cognitive-predictors-of-2-year-follow-up-abnormalities-in-early-onset-first-episode-psychosis
#16
Josefina Castro-Fornieles, Nuria Bargalló, Anna Calvo, Celso Arango, Immaculada Baeza, Ana Gonzalez-Pinto, Mara Parellada, Montserrat Graell, Carmen Moreno, Soraya Otero, Joost Janssen, Marta Rapado-Castro, Elena de la Serna
This study aims to examine regional gray matter (GM) changes over a period of 2 years in patients diagnosed with early-onset first-episode psychosis (EO-FEP), and to identify baseline predictors of abnormalities at the follow-up. Fifty-nine patients with EO-FEP aged 11-17 years were assessed. Magnetic resonance imaging was carried out at admission and 2 years later. Changes over time were assessed with voxel-based morphometry. Fifty-nine patients (34 schizophrenia-SCZ, 15 bipolar disorder-BP, and 10 other psychotic disorders) and 70 healthy controls were assessed...
July 13, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28689312/sleep-chronotype-and-sleep-hygiene-in-children-with-attention-deficit-hyperactivity-disorder-autism-spectrum-disorder-and-controls
#17
K B van der Heijden, R J Stoffelsen, A Popma, H Swaab
Sleep problems are highly prevalent in ADHD and autism spectrum disorder (ASD). Better insight in the etiology is of clinical importance since intervention and prevention strategies of sleep problems are directed at underlying mechanisms. We evaluated the association of sleep problems and sleep patterns with sleep hygiene (behavioral/environmental practices that influence sleep quality, e.g. caffeine use), access to electronic media, chronotype, and anxiety/depression in children aged 6-12 years with ADHD, ASD, or typical development (TD) using parental questionnaires...
July 8, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28688012/sex-differences-in-risk-based-decision-making-in-adolescents-with-conduct-disorder
#18
Justina Sidlauskaite, Karen González-Madruga, Areti Smaragdi, Roberta Riccelli, Ignazio Puzzo, Molly Batchelor, Harriet Cornwell, Luke Clark, Edmund J S Sonuga-Barke, Graeme Fairchild
Altered decision making processes and excessive risk-seeking behaviours are key features of conduct disorder (CD). Previous studies have provided compelling evidence of abnormally increased preference for risky options, higher sensitivity to rewards, as well as blunted responsiveness to aversive outcomes in adolescents with CD. However, most studies published to date have focused on males only; thus, it is not known whether females with CD show similar alterations in decision making. The current study investigated potential sex differences in decision making and risk-seeking behaviours in adolescents with CD...
July 7, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28688011/separation-anxiety-among-birth-assigned-male-children-in-a-specialty-gender-identity-service
#19
Doug P VanderLaan, Alanna Santarossa, A Natisha Nabbijohn, Hayley Wood, Allison Owen-Anderson, Kenneth J Zucker
Previous research suggested that separation anxiety disorder (SAD) is overrepresented among birth-assigned male children clinic-referred for gender dysphoria (GD). The present study examined maternally reported separation anxiety of birth-assigned male children assessed in a specialty gender identity service (N = 360). SAD was determined in relation to DSM-III and DSM-IV criteria, respectively. A dimensional metric of separation anxiety was examined in relation to several additional factors: age, ethnicity, parental marital status and social class, IQ, gender nonconformity, behavioral and emotional problems, and poor peer relations...
July 7, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28685401/high-maternal-vitamin-d-levels-in-early-pregnancy-may-protect-against-behavioral-difficulties-at-preschool-age-the-rhea-mother-child-cohort-crete-greece
#20
Vasiliki Daraki, Theano Roumeliotaki, Katerina Koutra, Georgia Chalkiadaki, Marianna Katrinaki, Andriani Kyriklaki, Mariza Kampouri, Katerina Margetaki, Marina Vafeiadi, Stathis Papavasiliou, Manolis Kogevinas, Leda Chatzi
Animal studies suggest that prenatal vitamin D status may affect fetal brain growth. However, human studies are scarce with conflicting results. We aimed to investigate the association of maternal 25-hydroxyvitamin D [25(OH) D] levels with multiple neurodevelopmental outcomes at 4 years of age. We included 487 mother-child pairs from the prospective pregnancy cohort, "Rhea" in Crete, Greece. Maternal serum 25(OH) D concentrations were measured at the first prenatal visit (13 ± 2.4 weeks). Cognitive functions at 4 years were assessed by means of the McCarthy Scales of Children's Abilities...
July 6, 2017: European Child & Adolescent Psychiatry
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