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Surgical Oncology Clinics of North America

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https://www.readbyqxmd.com/read/28576188/update-of-practical-radiation-oncology-management-trends-for-surgeons
#1
EDITORIAL
Adam Raben
No abstract text is available yet for this article.
July 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28576187/foreword
#2
EDITORIAL
Nicholas J Petrelli
No abstract text is available yet for this article.
July 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28576186/novel-opportunities-to-use-radiation-therapy-with-immune-checkpoint-inhibitors-for-melanoma-management
#3
REVIEW
Kamran A Ahmed, Sungjune Kim, Louis B Harrison
Immunotherapy has revolutionized the systemic management of numerous malignancies. Nowhere has the proven benefit of these agents in clinical practice been more evident than in the management of advanced melanoma. Numerous preclinical studies have revealed the potential benefit of immune-priming radiotherapy in stimulating tumor-specific immune responses. This signal for immune activation may lead to clinically relevant synergy with immune checkpoint inhibitors against malignant cells. In this review, the authors summarize the current data outlining the role radiation therapy may play in the management of advanced melanoma alongside immune checkpoint inhibitors...
July 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28576185/brachytherapy-in-the-management-of-prostate-cancer
#4
REVIEW
Bradley J Stish, Brian J Davis, Lance A Mynderse, Christopher L Deufel, Richard Choo
Brachytherapy is performed by directly inserting radioactive sources into the prostate gland and is an important treatment option for appropriately selected men with prostate adenocarcinoma. Brachytherapy provides highly conformal radiotherapy and delivers tumoricidal doses that exceed those administered with external beam radiation therapy. There is a significant body of literature supporting the excellent long-term oncologic and safety outcomes achieved when brachytherapy is used for men in all risk categories of nonmetastatic prostate cancer...
July 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28576184/radiation-oncology-management-of-stage-i-iii-cervix-cancer
#5
REVIEW
Lana de Souza Lawrence
Radiotherapy plays a critical role in the management of cervix carcinoma, in the adjuvant setting for patients with high-risk pathologic features and in the definitive setting for locoregionally advanced disease. External beam radiotherapy fields encompass potential areas of microscopic disease spread in addition to known areas of gross disease. In the presence of gross disease, however, escalation of dose is required that is best accomplished using a brachytherapy boost to spare surrounding normal organs from toxicity...
July 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28576183/radiotherapy-for-anal-cancer-intensity-modulated-radiotherapy-and-future-directions
#6
REVIEW
Serguei A Castaneda, Lindsay B Romak
The treatment of anal cancer has evolved remarkably in the past 30 years. Definitive chemoradiotherapy is the standard of care, allowing organ preservation and maintenance of continence for most patients. This article reviews recent advances in radiotherapy planning and delivery that have resulted in improvements in treatment-related toxicity. Most notably, the advent and wide adoption of intensity-modulated radiotherapy provides a superior toxicity profile compared with older techniques, while maintaining similar oncologic outcomes...
July 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28576182/evolving-role-of-radiotherapy-in-the-management-of-rectal-carcinoma
#7
REVIEW
Clayton A Smith, Lisa A Kachnic
Management of locally advanced rectal cancer has evolved over time from surgical resection alone to multimodality therapy with preoperative radiation, chemotherapy, and total mesorectal excision resulting in excellent local control rates. Refinements in neoadjuvant therapies and their sequencing have improved pathologic complete response rates such that consideration of selective radiation and nonoperative management are now active clinical trial questions. Advances in radiation treatment planning and delivery techniques may allow for further reduction in acute treatment-related toxicity in select patient populations...
July 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28576181/the-role-of-radiation-therapy-for-pancreatic-cancer-in-the-adjuvant-and-neoadjuvant-settings
#8
REVIEW
Shahed N Badiyan, Jason K Molitoris, Michael D Chuong, William F Regine, Adeel Kaiser
Pancreatic cancer is the third leading cause of cancer-related death in the United States. Although surgery remains the only curative treatment, chemotherapy and radiation therapy are frequently used. In the adjuvant setting, radiation is usually delivered with chemotherapy to eradicate residual microscopic or macroscopic disease in the resection bed. Neoadjuvant radiation therapy has become more frequently utilized. This article reviews the historical and modern literature regarding radiation therapy in the neoadjuvant and adjuvant settings, focusing on the evolution of radiation therapy techniques and clinical trials in an attempt to identify patients best suited to receiving radiation therapy...
July 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28576180/optimal-use-of-combined-modality-therapy-in-the-treatment-of-esophageal-cancer
#9
REVIEW
Talha Shaikh, Joshua E Meyer, Eric M Horwitz
Esophageal cancer is associated with a poor prognosis with 5-year survival rates of approximately 15% to 20%. Although patients with early stage disease may adequately be treated with a single modality, combined therapy typically consisting of neoadjuvant chemoradiation followed by esophagectomy is being adopted increasingly in patients with locally advanced disease. In patients who are not surgical candidates, definitive chemoradiation is the preferred treatment approach. All patients with newly diagnosed esophageal cancer should be evaluated in the multidisciplinary setting by a surgeon, radiation oncologist, and medical oncologist owing to the importance of each specialty in the management of these patients...
July 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28576179/management-of-stage-i-lung-cancer-with-stereotactic-ablative-radiation-therapy
#10
REVIEW
Tu Dan, Noelle L Williams
Early stage non-small cell lung cancer is a growing clinical entity with evolving standards of care. With the adoption of lung screening guidelines, the incidence of early stage disease is expected to increase. Surgical resection for early stage disease has been considered standard of care; however, there is evidence that stereotactic ablative radiation therapy (SABR) may be a viable alternate to surgery. In the last decade, advances in image guidance, treatment planning systems, and improved spatial accuracy of treatment delivery have converged to result in the effective use of SABR in the treatment of early stage lung cancer...
July 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28576178/updates-in-postmastectomy-radiation
#11
REVIEW
Jean L Wright, Arti Parekh
Although the use of postmastectomy radiation therapy (PMRT) is widely accepted in certain clinical situations, areas of controversy persist for some clinical scenarios. In addition, with significant shifts in the management of breast cancer, including omission of axillary nodal dissection in select sentinel node-positive patients and increased use of neoadjuvant chemotherapy, new clinical challenges have arisen regarding the role of PMRT. This article reviews the data to support current recommendations for postmastectomy radiation and explores areas of controversy and the studies that guide clinicians in these scenarios...
July 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28576177/updates-in-the-treatment-of-breast-cancer-with-radiotherapy
#12
REVIEW
Serguei A Castaneda, Jon Strasser
Breast-conserving therapy is one of the most remarkable achievements of modern cancer care. The authors review the evidence supporting the role of adjuvant radiotherapy as the standard of care for breast cancer after breast-conserving surgery, consensus guidelines for margins in invasive cancer disease and ductal carcinoma in situ, the role of partial-breast irradiation and hypofractionated whole-breast irradiation, and the evolving indications for postmastectomy radiation therapy and extent of nodal coverage...
July 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28576176/controversies-in-postoperative-irradiation-of-oropharyngeal-cancer-after-transoral-surgery
#13
REVIEW
Sue S Yom, Jon Mallen-St Clair, Patrick K Ha
Transoral surgery (TOS) is a novel technology whose adoption is expanding in the United States and other countries. TOS offers the possibility of a minimally invasive surgical approach to head and neck cancers. Its most frequent application has been in oropharyngeal cancers (OPC), of which most are associated with human papillomavirus (HPV). For HPV-associated OPC, where high response and survival rates are expected, deintensification of standard therapy is a major area of clinical research. In HPV-OPC, traditional pathologic risk factors indicating a need for adjuvant radiation or chemoradiation may not apply as strongly...
July 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28576175/update-on-radiotherapy-for-central-nervous-system-malignancies
#14
REVIEW
Eric Kemmerer, Sunjay Shah
Malignancies arising from the central nervous system are rare. Brain metastases, in contrast, are perhaps the most common neurologic complication of cancer. Radiotherapy, as part of combined modality therapy, continues to evolve with the advancement of stereotactic radiosurgery indications, the addition of new technologies, such as alternating electric field therapy, and mounting advances in the complex biology of these entities. The explosion of new clinical trials combined with newly discovered molecular markers suggest the beginning of a paradigm shift in the management of these challenging malignancies that will allow for future risk-stratification strategies...
July 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28279475/updates-in-esophagogastric-cancer
#15
EDITORIAL
David H Ilson
No abstract text is available yet for this article.
April 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28279474/gastric-and-esophageal-cancer-2017
#16
EDITORIAL
Nicholas J Petrelli
No abstract text is available yet for this article.
April 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28279473/issues-in-the-management-of-esophagogastric-cancer-in-geriatric-patients
#17
REVIEW
Elizabeth Won
Esophagogastric cancers predominantly affect older adults; however, older patients are less likely to be recommended for both curative and palliative treatment. Older patients have unique challenges that need to be addressed during their oncologic care. Tools such as complete geriatric assessments may help to better identify fit older adults and stratify patients for aggressive treatment strategies. This review evaluates the current knowledge and the remaining challenges in optimally managing elderly patients with esophagogastric cancers...
April 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28279472/nutritional-support-in-esophagogastric-cancers
#18
REVIEW
Elliott Birnstein, Mark Schattner
Esophageal and gastric cancers are common malignancies, both in the United States and worldwide, that carry significant morbidity and mortality. Malnutrition is a common complication in patients with esophageal and gastric cancers and it portends a poor prognosis. For patients who undergo surgical therapy for these types of cancers, preoperative and postoperative nutritional optimization have been shown to improve outcomes. The support can be accomplished in different manners, including orally, enterally, or parentally...
April 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28279471/current-progress-in-human-epidermal-growth-factor-receptor-2-targeted-therapies-in%C3%A2-esophagogastric-cancer
#19
REVIEW
Yelena Y Janjigian, Maria Ignez Braghiroli
Esophagogastric cancer is a worldwide health problem. The addition of the epidermal growth factor receptor 2 (HER2)-directed antibody trastuzumab to chemotherapy increased the overall survival of patients with metastatic HER2-positive esophagogastric cancer. This article discusses the available data to support HER2 as validated biomarker and recently completed and ongoing clinical trials of HER2-directed agents in metastatic and localized disease. Also reviewed is the mechanisms of resistance for HER2-directed therapy and ongoing research strategies including new imaging techniques and studies with patient-derived xenografts...
April 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28279470/novel-targeted-therapies-for-esophagogastric-cancer
#20
REVIEW
Steven B Maron, Daniel V T Catenacci
Gastroesophageal cancer (GEC) remains a major cause of cancer-related mortality worldwide. Although the incidence of distal gastric adenocarcinoma (GC) is declining in the United States, proximal esophagogastric junction adenocarcinoma (EGJ) is increasing in incidence. GEC, including GC and EGJ, is treated uniformly in the metastatic setting. Overall survival in the metastatic setting remains poor. Molecular characterization of GEC has identified mutations and copy number variations, along with other oncogenes, biomarkers, and immuno-oncologic checkpoints that may serve as actionable therapeutic targets...
April 2017: Surgical Oncology Clinics of North America
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