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Surgical Oncology Clinics of North America

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https://www.readbyqxmd.com/read/29935693/current-management-of-peritoneal-surface-malignancy
#1
EDITORIAL
Edward A Levine
No abstract text is available yet for this article.
July 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29935692/peritoneal-malignancies
#2
EDITORIAL
Timothy M Pawlik
No abstract text is available yet for this article.
July 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29935691/palliative-management-of-advanced-peritoneal-carcinomatosis
#3
REVIEW
Laura A Lambert, Ryan J Hendrix
Despite advances in the management of peritoneal carcinomatosis, morbidity remains high with survival often measured in weeks to months. Patients are often subjected to symptoms and complications that impact quality of life. Much of the management revolves around palliation of symptoms and providing support and resources to address emotional and existential concerns. This article reviews surgical and nonsurgical palliative treatments for the symptoms and complications associated with advanced, incurable peritoneal carcinomatosis...
July 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29935690/peritoneal-metastases-from-colorectal-cancer-treatment-principles-and-perspectives
#4
REVIEW
Diane Goéré, Isabelle Sourrouille, Maximiliano Gelli, Léonor Benhaim, Matthieu Faron, Charles Honoré
Peritoneal metastases are the third most common site of recurrence of colorectal cancer. Diagnosis is difficult and often made at an advanced stage even on imaging. Curative treatment relies on complete cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (HIPEC), which dramatically improves survival in selected patients. Main prognostic factors are based on the extent of the peritoneal disease and the completeness of surgery. Therefore, identifying patients at high risk of developing peritoneal metastases with the aim of diagnosing and treating patients at an early stage appears crucial...
July 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29935689/peritoneal-metastases-from-appendiceal-cancer
#5
REVIEW
Konstantinos I Votanopoulos, Perry Shen, Aleksander Skardal, Edward A Levine
The early symptoms of appendiceal cancer may mimic the clinical picture of appendicitis. Most patients are diagnosed incidentally during surgical exploration or late when peritoneal or systemic dissemination has already occurred, as colonoscopy rarely will diagnose an appendiceal cancer. Systemic/extraperitoneal metastases are distinctly unusual for appendiceal mucinous lesions.
July 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29935688/peritoneal-metastases-from-malignant-mesothelioma
#6
REVIEW
Claire Yue Li, H Richard Alexander
Diffuse malignant peritoneal mesothelioma (MPM) is a rare cancer that is ultimately fatal in almost all afflicted individuals. Morbidity and mortality from MPM is due to its propensity to progress locoregionally within the abdominal cavity. Patients with MPM most commonly present with nonspecific abdominal symptoms that usually lead to diagnosis when the condition is relatively advanced. MPM is considered a chemotherapy-resistant malignancy.
July 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29935687/evolving-treatment-strategies-and-outcomes-in-advanced-gastric-cancer-with-peritoneal-metastasis
#7
REVIEW
Fadi S Dahdaleh, Kiran K Turaga
Gastric cancer (GC) has a predilection to metastasize to the peritoneum, denoting a poor prognosis. Treatment strategies available for advanced GC have significantly evolved over time and can be categorized into systemic, regional, and surgical. Although systemic therapies have been the mainstay for the treatment of advanced GC, their ability in achieving long-term survival in patients with peritoneal involvement is modest at best. This article describes advances in combined modality treatment of peritoneal metastases, specifically with an emphasis on peritoneal-directed therapies...
July 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29935686/learning-curve-training-program-and-monitorization-of-surgical-performance-of-peritoneal-surface-malignancies-centers
#8
REVIEW
Shigeki Kusamura, Santiago González-Moreno, Eran Nizri, Dario Baratti, Stefano Guadagni, Marcello Guaglio, Luigi Battaglia, Marcello Deraco
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy is a complex procedure with high cost and significant morbidity and mortality. The associated learning curve is steep and could reliably be evaluated using specific statistics. Risk-adjusted sequential probability ratio test is an effective and robust method to monitor surgical performance in the learning and audit phase of a peritoneal surface malignancies center development. The most critical factor associated with surgical performance is mentoring of the trainee by an expert...
July 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29935685/techniques-and-safety-issues-for-intraperitoneal-chemotherapy
#9
REVIEW
Santiago González-Moreno, Gloria Ortega-Pérez, Oscar Alonso-Casado, Javier Galipienzo-García, Manuel J Linero-Noguera, David Salvatierra-Díaz
Different techniques for delivering perioperative intraperitoneal chemotherapy have been described, but no significant differences have been found among them. Hyperthermic intraperitoneal chemotherapy (HIPEC) is a safe treatment for the patient and for the health care workers involved in the procedure provided standard protective and environmental measures are employed.
July 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29935684/pharmacokinetics-and-tissue-transport-of-intraperitoneal-chemotherapy
#10
REVIEW
Nick Lagast, Charlotte Carlier, Wim P Ceelen
The presence of a peritoneal barrier results in a pharmacokinetic advantage associated with intraperitoneal (IP) delivery of anticancer drugs. The anticancer efficacy of IP chemotherapy depends, however, on its ability to penetrate the tumor stroma. Tumor tissue transport is governed by diffusion and convection and is affected by numerous physical, biological, and pharmaceutical variables. From preclinical and clinical studies, it appears that tissue penetration after IP chemotherapy delivery is very limited...
July 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29935683/genomics-of-peritoneal-malignancies
#11
REVIEW
Enusha Karunasena, Jonathan Sham, Kevin Wyatt McMahon, Nita Ahuja
The peritoneum protects the intraabdominal organs. This function is exploited by aggressive cancers originating from organs within the abdomen, resulting in peritoneal metastasis. We discuss genomic variants that may lead to peritoneal metastasis from multiple cancers. Peritoneal malignancies are attributed to epithelial-mesenchymal transition. These metastatic lesions harbor similar genetic mutations to the primary tumor yet may manifest clone-specific aberrations that promote propagation. Peritoneal metastasis are increasingly being treated with surgical resection as an adjunct to radiation, chemotherapy, and other biologic therapies...
July 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29935682/patient-selection-for-cytoreductive-surgery
#12
REVIEW
Travis E Grotz, Keith F Fournier, Paul F Mansfield
The peritoneal malignancies span the biologic spectrum of aggressiveness from the indolent growth pattern and superficial nature of well-differentiated mucinous appendiceal adenocarcinoma to the rapidly growing and invasive nature of poorly differentiated signet ring cell adenocarcinomas of the appendix, colon, and stomach. An understanding of the biology, distribution, and volume of disease is critical to appropriately selecting patients for cytoreduction and HIPEC with the goal of long-term survival. Herein the authors discuss appropriate the evaluation and selection of patients for with peritoneal surface malignancies for cytoreduction and HIPEC...
July 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29935681/imaging-for-peritoneal-metastases
#13
REVIEW
Russell N Low, Robert M Barone
MRI provides considerable advantages for imaging of patients with peritoneal tumor. Its inherently superior contrast resolution compared with computed tomography allows MRI to more accurately depict small peritoneal tumors that are often missed on other imaging tests. Combining different contrast mechanisms, including diffusion-weighted MRI and gadolinium-enhanced MRI, provides a powerful tool for preoperative and surveillance imaging in patients being considered for cytoreductive surgery and heated intraperitoneal chemotherapy...
July 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29935680/peritoneal-metastases-a-frontier-for-progress
#14
REVIEW
Paul H Sugarbaker
The treatments for peritoneal metastases have evolved over 30 years. Now the concepts that guided clinicians are being tested in clinical trials to optimize standardized treatment regimens. The essential features of a successful management plan are cytoreductive surgery combined with cancer chemotherapy in a large volume of intraperitoneal fluid administered into the peritoneal space. The cytotoxicity of the cancer chemotherapy is maximized by moderate hyperthermia. The patients must be carefully selected using well-defined prognostic indicators...
July 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29496099/colon-cancer-the-road-traveled
#15
EDITORIAL
Mark W Arnold
No abstract text is available yet for this article.
April 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29496098/colon-cancer
#16
EDITORIAL
Timothy M Pawlik
No abstract text is available yet for this article.
April 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29496097/lymph-node-metastasis-in-colorectal-cancer
#17
REVIEW
Ming Jin, Wendy L Frankel
Pathologic examination of lymph nodes in patients with cancer remains crucial for postoperative treatment and prognosis prediction. In this article, the authors aim to review several important and challenging issues regarding lymph node metastasis in colorectal cancer using the AJCC staging manual, College of American Pathologists cancer protocol, as well as the literature. These topics include lymph node staging, the definition and controversies in tumor deposits, isolated tumor cells in lymph node and micrometastasis, lymph node ratio as a prognostic stratification factor, and neoadjuvant treatment effect in rectal cancer...
April 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29496096/surgical-treatment-of-metastatic-colorectal-cancer
#18
REVIEW
Jeffery Chakedis, Carl R Schmidt
Surgical treatment of metastatic colorectal cancer offers a chance for cure or prolonged survival, particularly for those with more favorable prognostic factors and limited tumor burden. The treatment plan requires multidisciplinary evaluation because multiple therapy options exist. Advanced surgical techniques, adjuncts to resection, and modern chemotherapy all contribute to best outcomes for patients with hepatic metastases. Although cure is less common for patients with metastasis to lung or peritoneum, surgical resection for the former and cytoreduction and intraperitoneal chemotherapy for the latter may help to achieve cancer control in selected patients...
April 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29496095/maximizing-the-effectiveness-of-colonoscopy-in-the-prevention-of-colorectal-cancer
#19
REVIEW
John F Sullivan, John A Dumot
Colonoscopy is a proven screening test for colorectal cancer; maximizing its effectiveness is the best way to decrease interval colorectal cancer. The adenoma detection rate can be improved by monitoring physician detection rates. Assistive devices and innovative endoscopic equipment may also decrease adenoma miss rates. Complete polypectomy of adenomatous lesions and recommending the proper date for the next examination are important considerations. Advanced polypectomy techniques including endoscopic mucosal resection and endoscopic mucosal dissection have a clear role in the nonsurgical management of large laterally spreading adenomatous polyps that previously would have required surgical resection...
April 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29496094/clinical-trials-and-progress-in-metastatic-colon-cancer
#20
REVIEW
Kabir Mody, Tanios Bekaii-Saab
Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide but associated mortality has declined in recent decades. Genomic profiling of the disease has resulted in the definition of subsets of patients-for example, KRAS, NRAS, or BRAF mutated; Her2 amplified; and mismatch repair deficient-which has enabled personalization of therapeutic decision making. These subsets are guiding drug development and combination therapy approaches using both targeted therapies and immunotherapies. Further refinement based on molecular discoveries and the emergence of newer technologies to enable new discoveries allow for great optimism for the future on behalf of patients with colon cancer...
April 2018: Surgical Oncology Clinics of North America
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