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Surgical Oncology Clinics of North America

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https://www.readbyqxmd.com/read/29496099/colon-cancer-the-road-traveled
#1
EDITORIAL
Mark W Arnold
No abstract text is available yet for this article.
April 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29496098/colon-cancer
#2
EDITORIAL
Timothy M Pawlik
No abstract text is available yet for this article.
April 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29496097/lymph-node-metastasis-in-colorectal-cancer
#3
REVIEW
Ming Jin, Wendy L Frankel
Pathologic examination of lymph nodes in patients with cancer remains crucial for postoperative treatment and prognosis prediction. In this article, the authors aim to review several important and challenging issues regarding lymph node metastasis in colorectal cancer using the AJCC staging manual, College of American Pathologists cancer protocol, as well as the literature. These topics include lymph node staging, the definition and controversies in tumor deposits, isolated tumor cells in lymph node and micrometastasis, lymph node ratio as a prognostic stratification factor, and neoadjuvant treatment effect in rectal cancer...
April 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29496096/surgical-treatment-of-metastatic-colorectal-cancer
#4
REVIEW
Jeffery Chakedis, Carl R Schmidt
Surgical treatment of metastatic colorectal cancer offers a chance for cure or prolonged survival, particularly for those with more favorable prognostic factors and limited tumor burden. The treatment plan requires multidisciplinary evaluation because multiple therapy options exist. Advanced surgical techniques, adjuncts to resection, and modern chemotherapy all contribute to best outcomes for patients with hepatic metastases. Although cure is less common for patients with metastasis to lung or peritoneum, surgical resection for the former and cytoreduction and intraperitoneal chemotherapy for the latter may help to achieve cancer control in selected patients...
April 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29496095/maximizing-the-effectiveness-of-colonoscopy-in-the-prevention-of-colorectal-cancer
#5
REVIEW
John F Sullivan, John A Dumot
Colonoscopy is a proven screening test for colorectal cancer; maximizing its effectiveness is the best way to decrease interval colorectal cancer. The adenoma detection rate can be improved by monitoring physician detection rates. Assistive devices and innovative endoscopic equipment may also decrease adenoma miss rates. Complete polypectomy of adenomatous lesions and recommending the proper date for the next examination are important considerations. Advanced polypectomy techniques including endoscopic mucosal resection and endoscopic mucosal dissection have a clear role in the nonsurgical management of large laterally spreading adenomatous polyps that previously would have required surgical resection...
April 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29496094/clinical-trials-and-progress-in-metastatic-colon-cancer
#6
REVIEW
Kabir Mody, Tanios Bekaii-Saab
Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide but associated mortality has declined in recent decades. Genomic profiling of the disease has resulted in the definition of subsets of patients-for example, KRAS, NRAS, or BRAF mutated; Her2 amplified; and mismatch repair deficient-which has enabled personalization of therapeutic decision making. These subsets are guiding drug development and combination therapy approaches using both targeted therapies and immunotherapies. Further refinement based on molecular discoveries and the emergence of newer technologies to enable new discoveries allow for great optimism for the future on behalf of patients with colon cancer...
April 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29496093/the-economics-of-colon-cancer
#7
REVIEW
Guy R Orangio
The economic burden of cancer on the national health expenditure is billions of dollars. The economic cost is measured on direct and indirect medical costs, which vary depending on stage at diagnosis, patient age, type of medical services, and site of service. Costs vary by region, physician behavior, and patient preferences. When analyzing the economic burden of survivors of colon cancer, we cannot forget the societal burden. Post-acute care and readmissions are major economic burdens. People with colon cancer have to be followed for their lifetime...
April 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29496092/population-screening-for-hereditary-colorectal-cancer
#8
REVIEW
Heather Hampel
Colorectal cancer can be caused by hereditary cancer syndromes such as Lynch syndrome and the polyposis syndromes. Tumor screening for Lynch syndrome has been recommended by several professional organizations. In addition, it has been shown that patients with microsatellite unstable colorectal cancer can benefit from immunotherapy. Unfortunately, universal tumor screening for Lynch syndrome has not been implemented at all hospitals yet. More recent studies have found that the prevalence of all hereditary cancer syndromes is around 10%, and for those diagnosed under age 50, it is closer to 16%...
April 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29496091/minimally-invasive-surgical-approaches-to-colon-cancer
#9
REVIEW
Jean F Salem, Sriharsha Gummadi, John H Marks
Colon cancer remains the most common abdominal visceral malignancy affecting both men and women in America. Open colectomy has been the standard of care for colon cancer patients the past 100 years; although highly effective, the major trauma associated with it has a significant morbidity rate and represents a large operation for patients to recover from. Minimally invasive colon surgery was developed as a new and alternative option, and surgeons aim to continue to make it simpler, more reproducible, and easier to teach and learn...
April 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29496090/colorectal-cancer-imaging-conundrums
#10
REVIEW
Nathan C Hall, Alexander T Ruutiainen
Progressive technological advancements in imaging have significantly improved the preoperative sensitivity for the detection of very small foci of regionally- or hematogenously-metastatic colorectal cancer. Unfortunately, this information has not translated to continued linear gains in patient survival, and might even result in the false-positive upstaging of some cases: these are two conundrums in the imaging of colorectal cancer. Both conundrums might be resolved by the widespread use of real-time imaging guidance during operative procedures...
April 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29496089/colon-cancer-inflammation-associated-cancer
#11
REVIEW
Sherief Shawki, Jean Ashburn, Steven A Signs, Emina Huang
Colitis-associated cancer is a relatively rare form of cancer with an unclear pathogenesis. Colitis-associated cancer serves as a prototype of inflammation-associated cancers. Advanced colonoscopic techniques are considered standard of care for surveillance in patients with long-standing colitis, especially those with other risk factors, including sclerosing cholangitis and a family history of colorectal cancer. When colitis-associated cancer is diagnosed, the standard operation involves total proctocolectomy...
April 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29496088/colon-cancer-what-we-eat
#12
REVIEW
Pan Pan, Jianhua Yu, Li-Shu Wang
A higher incidence of colorectal cancer (CRC) is observed in Oceania and Europe, whereas Africa and Asia have a lower incidence. CRC is largely preventable by adapting a healthy lifestyle, such as healthy diet, adequate physical activity, and avoiding obesity. This review summarizes the latest work available, mainly epidemiologic studies, to examine the relationship between diet and CRC. Higher intake of red/processed meat could increase the CRC risk, whereas fibers, especially from whole grains and cereals, as well as fruit and vegetables may decrease the CRC risk...
April 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29496087/systemic-therapy-for-colon-cancer
#13
REVIEW
Christina Wu
Systemic treatments for patients with colon cancer has expanded broadly beyond 5-fluorouracil based chemotherapy. For early stage colon cancer patients who are considering adjuvant chemotherapy, multiple factors such as the risk of disease recurrence, absolute survival benefit of chemotherapy, treatment toxicity, and patient comorbid medical conditions must be taken into account. In the metastatic setting, biomarkers such as KRAS/NRAS/BRAF mutation, microsatellite instability status, and left- versus right-sided colon cancer have helped oncologists to tailor systemic treatment regimens, which include chemotherapy, targeted therapy, and immunotherapy...
April 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29132570/integrating-new-knowledge-and-surgical-innovation-into-the-diagnosis-and-management-of-breast-cancer
#14
EDITORIAL
Kelly K Hunt
No abstract text is available yet for this article.
January 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29132569/innovation-in-the-diagnosis-and-management-of-breast-cancer
#15
EDITORIAL
Timothy M Pawlik
No abstract text is available yet for this article.
January 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29132568/molecular-subtypes-and-local-regional-control-of-breast-cancer
#16
REVIEW
Simona Maria Fragomeni, Andrew Sciallis, Jacqueline S Jeruss
In the era of personalized medicine, there has been significant progress regarding the molecular analysis of breast cancer subtypes. Research efforts have focused on how classification of subtypes could provide information on prognosis and influence treatment planning. Although much is known about the impact of different molecular subtypes on disease-specific survival, more recent studies have investigated the role of the different molecular subtypes on local-regional recurrence. This is an area of active study, and in recent years there has been significant progress...
January 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29132567/lobular-breast-cancer-different-disease-different-algorithms
#17
REVIEW
Anita Mamtani, Tari A King
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer, with a unique pathogenesis and distinct clinical biology. ILCs display a characteristic loss of E-cadherin, are largely estrogen receptor positive, HER2 negative, and low to intermediate grade. These features portend a favorable prognosis, but there is a tendency for late recurrences and atypical metastases. ILCs tend to be insidious and infiltrative, which can pose a challenge for diagnosis, and emerging data suggest they may have a propensity for a differing response to standard therapies...
January 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29132566/are-there-alternative-strategies-for-the-local-management-of-ductal-carcinoma-in-situ
#18
REVIEW
Kelly J Rosso, Anna Weiss, Alastair M Thompson
The management of ductal carcinoma in situ (DCIS) has traditionally followed the evidence base for invasive breast cancer using surgery, radiation therapy, and drug therapy to remove the DCIS from the breast and reduce the risk of recurrence for both DCIS and invasive breast cancer. Because of concerns regarding the overtreatment of DCIS, randomized controlled trials have been established to test the outcomes (invasive breast cancer outcomes and patient-reported outcome measures) of active surveillance compared with guideline-concordant care for low-risk (for progression) DCIS...
January 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29132565/anatomy-and-breast-cancer-staging-is-it-still-relevant
#19
REVIEW
Jennifer K Plichta, Brittany M Campbell, Elizabeth A Mittendorf, E Shelley Hwang
Breast cancer staging concisely summarizes disease status, creating a framework for assessing and relaying prognostic information. The fundamental concepts and components of breast cancer staging are reviewed. The AJCC Cancer Staging Manual, which includes traditional anatomic factors, now includes additional tumor characteristics: tumor grade, estrogen receptor status, progesterone receptor status, human epidermal growth factor receptor 2 status, and (when available) multigene panel testing from the primary tumor...
January 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29132564/tomosynthesis-in-breast-cancer-imaging-how-does-it-fit-into-preoperative-evaluation-and-surveillance
#20
REVIEW
Mohammad Eghtedari, Catherine Tsai, Julie Robles, Sarah L Blair, Haydee Ojeda-Fournier
An important limitation of conventional two-dimensional mammography is the overlap of dense breast tissue obscuring masses. Digital breast tomosynthesis (DBT) has emerged as a mammographic technology that overcomes this limitation and is considered an overall better mammogram. DBT has been shown to detect significantly more breast cancer than conventional two-dimensional mammography, and to decrease the number of callbacks for diagnostic evaluation from screening mammography. Usually the callback evaluation is deemed to be overlap of tissue requiring no further management...
January 2018: Surgical Oncology Clinics of North America
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