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Mediators of Inflammation

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https://www.readbyqxmd.com/read/28428684/innate-immunity-of-adipose-tissue-in-rodent-models-of-local-and-systemic-staphylococcus-aureus-infection
#1
Andreas Schmid, Thomas Karrasch, Miriam Thomalla, Jutta Schlegel, Bernd Salzberger, Andreas Schäffler, Frank Hanses
Background. The role of adipose tissue in systemic inflammation during bacterial infection is unclear. Effects of Staphylococcus aureus infection on adipocytes in rodent models of experimental endocarditis and peritonitis, the impact of S. aureus infection on gene expression in epididymal and subcutaneous adipose tissue, and effects of S. aureus infection on the toll-like receptor-2- (TLR2-) cathelicidin pathway in vivo and in vitro were investigated. Material and methods. The rat model of catheter-induced S...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28420941/recent-advances-the-imbalance-of-cytokines-in-the-pathogenesis-of-inflammatory-bowel-disease
#2
REVIEW
Qingdong Guan, Jiguo Zhang
Cytokines play an important role in the immunopathogenesis of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, where they drive and regulate multiple aspects of intestinal inflammation. The imbalance between proinflammatory and anti-inflammatory cytokines that occurs in IBD results in disease progression and tissue damage and limits the resolution of inflammation. Targeting cytokines have been novel strategies in the treatment of IBD. Recent studies show the beneficial effects of anticytokine treatments to IBD patients, and multiple novel cytokines are found to be involved in the pathogenesis of IBD...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28408792/thrombopoietin-receptor-agonist-mitigates-hematopoietic-radiation-syndrome-and-improves-survival-after-whole-body-ionizing-irradiation-followed-by-wound-trauma
#3
Juliann G Kiang, Min Zhai, Pei-Jun Liao, Connie Ho, Nikolai V Gorbunov, Thomas B Elliott
Ionizing radiation combined with trauma tissue injury (combined injury, CI) results in greater mortality and H-ARS than radiation alone (radiation injury, RI), which includes thrombocytopenia. The aim of this study was to determine whether increases in numbers of thrombocytes would improve survival and mitigate H-ARS after CI. We observed in mice that WBC and platelets remained very low in surviving RI animals that were given 9.5 Gy (60)Co-γ-photon radiation, whereas only lymphocytes and basophils remained low in surviving CI mice that were irradiated and then given skin wounds...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28408791/all-trans-retinoic-acid-modulates-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway-targeting-tnf-%C3%AE-and-nitric-oxide-synthase-2-expression-in-colonic-mucosa-during-ulcerative-colitis-and-colitis-associated-cancer
#4
Hayet Rafa, Sarra Benkhelifa, Sonia AitYounes, Houria Saoula, Said Belhadef, Mourad Belkhelfa, Aziza Boukercha, Ryma Toumi, Imene Soufli, Olivier Moralès, Yvan de Launoit, Hassen Mahfouf, M'hamed Nakmouche, Nadira Delhem, Chafia Touil-Boukoffa
Colitis associated cancer (CAC) is the colorectal cancer (CRC) subtype that is associated with bowel disease such as ulcerative colitis (UC). The data on role of NF-κB signaling in development and progression of CAC were derived from preclinical studies, whereas data from human are rare. The aim of this work was to study the contribution of NF-κB pathway during UC and CAC, as well as the immunomodulatory effect of all-trans retinoic acid (AtRA). We analyzed the expression of NOS2, TNF-α, TLR4, and NF-κB, in colonic mucosa...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28408790/hbv-viral-load-and-liver-enzyme-levels-may-be-associated-with-the-wild-mbl2-aa-genotype
#5
Tuane Carolina Ferreira Moura, Ednelza da Silva Graça Amoras, Mauro Sérgio Araújo, Maria Alice Freitas Queiroz, Simone Regina Souza da Silva Conde, Sâmia Demachki, Rosimar Neris Martins-Feitosa, Luiz Fernando Almeida Machado, Izaura Maria Vieira Cayres-Vallinoto, Ricardo Ishak, Antonio Carlos Rosário Vallinoto
The present study investigated the frequencies of rs1800450 (MBL (⁎)B, G>A), rs1800451 (MBL (⁎)C, G>A), and rs5030737 (MBL (⁎)D, C>T) polymorphisms in exon 1 of the MBL2 gene among patients with chronic viral hepatitis. Blood samples from patients infected with hepatitis B virus (HBV; n = 65), hepatitis C virus (HCV; n = 92), and a noninfected control group (n = 300) were investigated. The presence of polymorphisms was detected using a real-time polymerase chain reaction to correlate with liver disease pathogenesis and fibrosis staging according to the Metavir classification...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28400679/erratum-to-establishment-of-a-consistent-l929-bioassay-system-for-tnf-%C3%AE-quantitation-to-evaluate-the-effect-of-lipopolysaccharide-phytomitogens-and-cytodifferentiation-agents-on-cytotoxicity-of-tnf-%C3%AE-secreted-by-adherent-human-mononuclear-cells
#6
https://www.readbyqxmd.com/read/28400678/key-role-of-stat4-deficiency-in-the-hematopoietic-compartment-in-insulin-resistance-and-adipose-tissue-inflammation
#7
Anca D Dobrian, Kaiwen Ma, Lindsey M Glenn, Margaret A Hatcher, Bronson A Haynes, Eric J Lehrer, Mark H Kaplan, Jerry L Nadler
Visceral adipose tissue (AT) inflammation is linked to the complications of obesity, including insulin resistance (IR) and type 2 diabetes. Recent data from our lab showed that germline deficiency in STAT4 reduces inflammation and improves IR in obese mice. The objective of this study was to determine the contribution of selective STAT4 deficiency in subsets of hematopoietic cells to IR and AT inflammation. To determine the contribution of hematopoietic lineage, we sublethally irradiated Stat4(-/-)C57Bl6 mice and reconstituted them with bone marrow cells (BMC) from Stat4(+/+)C57Bl6 congenic donors...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28400677/the-potential-role-of-aerobic-exercise-induced-pentraxin-3-on-obesity-related-inflammation-and-metabolic-dysregulation
#8
REVIEW
Aaron L Slusher, Chun-Jung Huang, Edmund O Acevedo
Obesity is defined as the excess accumulation of intra-abdominal body fat, resulting in a state of chronic, low-grade proinflammation that can directly contribute to the development of insulin resistance. Pentraxin 3 (PTX3) is an acute-phase protein that is expressed by a variety of tissue and cell sources and provides an anti-inflammatory property to downregulate the production of proinflammatory cytokines, in particular interleukin-1 beta and tumor necrosis factor alpha. Although PTX3 may therapeutically aid in altering the proinflammatory milieu in obese individuals, and despite elevated expression of PTX3 mRNA observed in adipose tissue, the circulating level of PTX3 is reduced with obesity...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28392632/acute-lung-injury-repair-and-remodeling-pulmonary-endothelial-and-epithelial-biology
#9
EDITORIAL
Yutong Zhao, Karen Ridge, Jing Zhao
No abstract text is available yet for this article.
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28392631/roles-of-dietary-amino-acids-and-their-metabolites-in-pathogenesis-of-inflammatory-bowel-disease
#10
REVIEW
Xianying Bao, Zemeng Feng, Jiming Yao, Tiejun Li, Yulong Yin
Inflammatory Bowel Disease (IBD) is a kind of chronic inflammation, which has increasing incidence and prevalence in recent years. IBD mainly divides into Crohn's disease (CD) and ulcerative colitis (UC). It is hard to cure IBD completely, and novel therapies are urgently needed. Amino acids (AAs) and their metabolites are regarded as important nutrients for humans and animals and also play an important role in IBD amelioration. In the present study, the potential protective effects of AAs and their metabolites on IBD had been summarized with the objective to provide insights into IBD moderating using dietary AAs and their metabolites as a potential adjuvant therapy...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28377641/the-correlation-of-cd206-cd209-and-disease-severity-in-beh%C3%A3-et-s-disease-with-arthritis
#11
Bunsoon Choi, Chang-Hee Suh, Hyoun-Ah Kim, Hasan M Sayeed, Seonghyang Sohn
The purpose of this study was to clarify the role of pattern recognition receptors in Behçet's disease (BD). The frequencies of several pattern recognition receptors (CD11b, CD11c, CD32, CD206, CD209, and dectin-1) were analyzed in patients with BD by flow cytometry, and cytokine levels, interleukin- (IL-) 18, IL-23, and IL-17A, were compared in plasma. The analysis was performed in active (n = 13) and inactive (n = 13) stages of BD patients. Rheumatoid arthritis patients (n = 19), as a disease control, and healthy control (HC) (n = 19) were enrolled...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28373747/andrographolide-activates-keap1-nrf2-are-ho-1-pathway-in-ht22-cells-and-suppresses-microglial-activation-by-a%C3%AE-42-through-nrf2-related-inflammatory-response
#12
Ji Yeon Seo, Euisun Pyo, Jin-Pyo An, Jinwoong Kim, Sang Hyun Sung, Won Keun Oh
Therapeutic approach of Alzheimer's disease (AD) has been gradually diversified. We examined the therapeutic and preventive potential of andrographolide, which is a lactone diterpenoid from Andrographis paniculata, and focused on the Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated heme oxygenase (HO)-1-inducing effects and the inhibitory activity of amyloid beta (Aβ)42-induced microglial activation related to Nrf2 and nuclear factor κB (NF-κB)-mediated inflammatory responses...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28373746/cyanidin-3-o-glucoside-modulates-the-in-vitro-inflammatory-crosstalk-between-intestinal-epithelial-and-endothelial-cells
#13
Daniela Ferrari, Francesco Cimino, Deborah Fratantonio, Maria Sofia Molonia, Romina Bashllari, Rossana Busà, Antonella Saija, Antonio Speciale
Intestinal epithelium represents a protective physical barrier and actively contributes to the mucosal immune system. Polarized basolateral intestinal secretion of inflammatory mediators, followed by activation of NF-κB signaling and inflammatory pathways in endothelial cells, efficiently triggers extravasation of neutrophils from the vasculature, therefore contributing to the development and maintenance of intestinal inflammation. Proper regulation of NF-κB activation at the epithelial interface is crucial for the maintenance of physiological tissue homeostasis...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28367002/tsg-6-downregulates-ifn-alpha-and-tnf-alpha-expression-by-suppressing-irf7-phosphorylation-in-human-plasmacytoid-dendritic-cells
#14
L Kui, G C Chan, P P W Lee
Proinflammatory cytokines such as TNF-α and type I interferons (IFN) are pathogenic signatures of systemic lupus erythematosus, and plasmacytoid dendritic cells (pDCs) play a major role by predominantly producing IFN-α. Given the rise of importance in identifying tumor necrosis stimulated gene 6 (TSG-6) as a key anti-inflammatory regulator, we investigate its function and its ability to counteract proinflammatory cytokine secretion by pDCs in vitro. CpG-A and R837 induced significant endogenous TSG-6 expression in the pDC cell-line GEN2...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28356656/cpg-type-a-induction-of-an-early-protective-environment-in-experimental-multiple-sclerosis
#15
James Crooks, Marco Gargaro, Carmine Vacca, Claudia Volpi, Matteo Pirro, Giulia Scalisi, Antonella Turco, Rita Romani, Davide Matino, Abdolmohamad Rostami, Paolo Puccetti, Bruno Gran, Francesca Fallarino
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory, demyelinating disease of the CNS that mimics human multiple sclerosis (MS), and it is thought to be driven by Th1 and Th17 myelin-reactive cells. Although adaptive immunity is clearly pivotal in the pathogenesis of EAE, with an essential role of CD4(+) T cells, little is known of early, innate responses in this experimental setting. CpG-rich oligodeoxynucleotides (ODNs), typically found in microbial genomes, are potent activators of TLR9 in plasmacytoid dendritic cells (pDCs)...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28352145/methotrexate-reduced-tnf-bioactivity-in-rheumatoid-arthritis-patients-treated-with-infliximab
#16
Delphine Dénarié, Mélanie Rinaudo-Gaujous, Thierry Thomas, Stéphane Paul, Hubert Marotte
Objectives. To evaluate methotrexate effect on tumor necrosis factor (TNF) alpha bioactivity during infliximab (IFX) therapy in rheumatoid arthritis (RA) patients and to correlate TNF bioactivity with antibody towards IFX (ATI) development and RA clinical response. Materials and Methods. Thirty-nine active women RA patients despite conventional synthetic disease modifying antirheumatic drugs (csDMARDs) requiring IFX therapy were enrolled, and clinical data and blood samples were recorded at baseline (W0) and at 6 weeks (W6), W22, and W54 of IFX treatment...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28348463/human-%C3%AE-defensin-3-reduces-tnf-%C3%AE-induced-inflammation-and-monocyte-adhesion-in-human-umbilical-vein-endothelial-cells
#17
Tianying Bian, Houxuan Li, Qian Zhou, Can Ni, Yangheng Zhang, Fuhua Yan
The aim of this study was to investigate the role of human β-defensin 3 (hBD3) in the initiation stage of atherosclerosis with human umbilical vein endothelial cells (HUVECs) triggered by tumor necrosis factor- (TNF-) α. The effects of hBD3 on TNF-α-induced endothelial injury and inflammatory response were evaluated. Our data revealed that first, hBD3 reduced the production of interleukin-6 (IL-6), IL-8, monocyte chemoattractant protein-1 (MCP-1), and macrophage migration inhibitory factor (MIF) in HUVECs in a dose-dependent manner...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28348462/nlrp3-deficiency-attenuates-renal-fibrosis-and-ameliorates-mitochondrial-dysfunction-in-a-mouse-unilateral-ureteral-obstruction-model-of-chronic-kidney-disease
#18
Honglei Guo, Xiao Bi, Ping Zhou, Shijian Zhu, Wei Ding
Background and Aims. The nucleotide-binding domain and leucine-rich repeat containing PYD-3 (NLRP3) inflammasome has been implicated in the pathogenesis of chronic kidney disease (CKD); however, its exact role in glomerular injury and tubulointerstitial fibrosis is still undefined. The present study was performed to identify the function of NLRP3 in modulating renal injury and fibrosis and the potential involvement of mitochondrial dysfunction in the murine unilateral ureteral obstruction (UUO) model of CKD...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28348461/am966-an-antagonist-of-lysophosphatidic-acid-receptor-1-increases-lung-microvascular-endothelial-permeability-through-activation-of-rho-signaling-pathway-and-phosphorylation-of-ve-cadherin
#19
Junting Cai, Jianxin Wei, Shuang Li, Tomeka Suber, Jing Zhao
Maintenance of pulmonary endothelial barrier integrity is important for reducing severity of lung injury. Lysophosphatidic acid (LPA) regulates cell motility, cytoskeletal rearrangement, and cell growth. Knockdown of LPA receptor 1 (LPA1) has been shown to mitigate lung injury and pulmonary fibrosis. AM966, an LPA1 antagonist exhibiting an antifibrotic property, has been considered to be a future antifibrotic medicine. Here, we report an unexpected effect of AM966, which increases lung endothelial barrier permeability...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28348460/epac1-blocks-nlrp3-inflammasome-to-reduce-il-1%C3%AE-in-retinal-endothelial-cells-and-mouse-retinal-vasculature
#20
Youde Jiang, Li Liu, Elizabeth Curtiss, Jena J Steinle
Inflammation is an important component of diabetic retinal damage. We previously reported that a novel β-adrenergic receptor agonist, Compound 49b, reduced Toll-like receptor 4 (TLR4) signaling in retinal endothelial cells (REC) grown in high glucose. Others reported that TLR4 activates high-mobility group box 1 (HMGB1), which has been associated with the NOD-like receptor 3 (NLRP3) inflammasome. Thus, we hypothesized that Epac1, a downstream mediator of β-adrenergic receptors, would block TLR4/HMGB1-mediated stimulation of the NLRP3 inflammasome, leading to reduced cleavage of caspase-1 and interleukin-1 beta (IL-1β)...
2017: Mediators of Inflammation
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