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Mediators of Inflammation

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https://www.readbyqxmd.com/read/29769839/a-novel-association-of-polymorphism-in-the-itga4-gene-encoding-the-vla-4-%C3%AE-4-subunit-with-increased-risk-of-alzheimer-s-disease
#1
Vladimira Durmanova, Zuzana Parnicka, Juraj Javor, Gabriel Minarik, Lubomir Vrazda, Barbora Vaseckova, Karin Gmitterova, Maria Kralova, Jan Pecenak, Peter Filipcik, Ivana Shawkatova
Alzheimer's disease (AD) is the most prevalent cause of dementia in elderly people worldwide. Many studies support the hypothesis that the inflammation of the CNS contributes to the neurodegeneration and disease progression. The integrin molecule α 4 β 1, also known as very late antigen 4 (VLA-4), belongs to adhesion molecules that activate the inflammatory process through the migration of immune cells into the CNS. Therefore, the objective of our study was to analyze the association between two polymorphisms located in the ITGA4 gene encoding the α 4 subunit of VLA-4 and the risk of AD...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29769838/selected-biomarkers-correlate-with-the-origin-and-severity-of-sepsis
#2
Michal Holub, Olga Džupová, Michaela Růžková, Alžběta Stráníková, Eva Bartáková, Jan Máca, Jiří Beneš, Heiko Herwald, Ondřej Beran
The microbial etiology and source of sepsis influence the inflammatory response. Therefore, the plasma levels of cytokines (IL-6, IL-8, and IL-10), chemokines (CCL2/MCP-1, MIP-1 β ), heparin-binding protein (HBP), soluble CD14 (sCD14), and cortisol were analyzed in blood from septic patients obtained during the first 96 hours of intensive care unit hospitalization. The etiology was established in 56 out of a total of 62 patients enrolled in the study. Plasma concentrations of MCP-1, sCD14, IL-6, and IL-10 were significantly higher in patients with community-acquired pneumonia (CAP; n = 10) and infective endocarditis (IE; n = 11) compared to those with bacterial meningitis (BM; n = 18)...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29769837/the-role-of-extracellular-adenosine-generation-in-the-development-of-autoimmune-diseases
#3
REVIEW
F Morandi, A L Horenstein, R Rizzo, F Malavasi
Adenosine (ADO) is an immunosuppressive molecule, which suppresses the immune responses by interacting with specific receptors expressed by immune effector cells. ADO is produced from ATP through the enzymatic activities of CD39 and CD73. Alternatively, ADO can be generated starting from NAD+ , which is metabolized by the concerted action of CD38, CD203a/PC-1, and CD73. The role of ADO in immunity has been characterized in the last years in physiology and in pathological settings. This review examines a panel of reports focused on the functions of ADO in the context of human autoimmune/inflammatory diseases and the selected animal models...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29743813/plasma-asprosin-concentrations-are-increased-in-individuals-with-glucose-dysregulation-and-correlated-with-insulin-resistance-and-first-phase-insulin-secretion
#4
Yuren Wang, Hua Qu, Xin Xiong, Yuyang Qiu, Yong Liao, Yingchun Chen, Yi Zheng, Hongting Zheng
Background: Adipokines are reported to participate in many common pathologic processes of glucose dysregulation, such as insulin resistance, β -cell dysfunction, and chronic inflammation. Objective: To detect the concentrations of plasma asprosin in subjects with impaired glucose regulation (IGR) and newly diagnosed type 2 diabetes (nT2DM) and its relationship to parameters of glucose and lipid metabolism, insulin resistance, and pancreatic β -cell function. Methods: 143 eligible participants were included and were divided into three groups including normal glucose regulation (NGR, n = 52), IGR ( n = 40), and nT2DM group ( n = 51)...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29743812/nmr-based-plasma-metabolomics-at-set-intervals-in-newborn-dairy-calves-with-severe-sepsis
#5
Abdullah Basoglu, Ismail Sen, Gaia Meoni, Leonardo Tenori, Amir Naseri
The aim of this first study was to reveal the new potential biomarkers by a metabolomics approach in severe septic calves. Sepsis is a common cause of morbidity and mortality in newborn dairy calves. The main challenges with the use of biomarkers of sepsis in domestic animals are their availability, cost, and time required to obtain a result. Metabolomics may offer the potential to identify biomarkers that define calf sepsis in terms of combined clinical, physiological, and pathobiological abnormalities. To our knowledge, this is the first study presenting an NMR- (nuclear magnetic resonance-) based plasma metabolomics at set intervals in neonatal septic calves...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29743811/the-immunoregulation-of-th17-in-host-against-intracellular-bacterial-infection
#6
REVIEW
Yonghong Li, Chaojun Wei, Hui Xu, Jing Jia, Zhenhong Wei, Rui Guo, Yanjuan Jia, Yu Wu, Yuanting Li, Xiaoming Qi, Zhenhao Li, Xiaoling Gao
T helper 17 cells (Th17) constitute a distinct subset of helper T cells with a unique transcriptional profile (STAT3, ROR γ , and ROR α ), cytokine production pattern (IL17 family), and requirement of specific cytokines for their differentiation (TGF- β , IL6, IL21, and IL23). Recent studies involving experimental animals and humans have shown that Th17/IL17 plays a crucial role in host defense against a variety of pathogens, including bacteria and viruses. The underlying mechanisms by which Th17 performs include dendritic cell (DC) regulation, neutrophil recruitment, Th1 modulation, and T regulatory cell (Treg) balance...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29743810/auricular-cartilage-regeneration-with-adipose-derived-stem-cells-in-rabbits
#7
Se-Joon Oh, Hee-Young Park, Kyung-Un Choi, Sung-Won Choi, Sung-Dong Kim, Soo-Keun Kong, Kyu-Sup Cho
Tissue engineering cell-based therapy using induced pluripotent stem cells and adipose-derived stem cells (ASCs) may be promising tools for therapeutic applications in tissue engineering because of their abundance, relatively easy harvesting, and high proliferation potential. The purpose of this study was to investigate whether ASCs can promote the auricular cartilage regeneration in the rabbit. In order to assess their differentiation ability, ASCs were injected into the midportion of a surgically created auricular cartilage defect in the rabbit...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29743809/evaluation-of-regulatory-immune-response-in-skin-lesions-of-patients-affected-by-nonulcerated-or-atypical-cutaneous-leishmaniasis-in-honduras-central-america
#8
Gabriela Venicia Araujo Flores, Carmen Maria Sandoval Pacheco, Thaise Yumie Tomokane, Wilfredo Sosa Ochoa, Concepción Zúniga Valeriano, Claudia Maria Castro Gomes, Carlos Eduardo Pereira Corbett, Marcia Dalastra Laurenti
In Honduras, Leishmania (L.) infantum chagasi causes both visceral leishmaniasis (LV) and nonulcerated or atypical cutaneous leishmaniasis (NUCL). NUCL is characterized by mononuclear inflammatory infiltration of the dermis, composed mainly of lymphocytes followed by macrophages with discrete parasitism. Considering that little is known about the pathogenesis of NUCL, the aim of this study was to evaluate the regulatory response in situ in skin lesions of patients affected by NUCL. Biopsies ( n = 20) from human cutaneous nonulcerative lesions were collected and processed by usual histological techniques...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29736154/decreased-il-33-production-contributes-to-trophoblast-cell-dysfunction-in-pregnancies-with-preeclampsia
#9
Hong Chen, Xiaobo Zhou, Ting-Li Han, Philip N Baker, Hongbo Qi, Hua Zhang
Preeclampsia (PE) is a life-threatening pregnancy complication which is related to aggradation of risk regarding fetal and maternal morbidity and mortality. Dysregulation of systemic inflammatory response and dysfunction of trophoblast cells have been proposed to be involved in the development and progression of PE. Some studies have demonstrated that interleukin-33 (IL-33) is an immunomodulatory cytokine that is associated with the immune regulation of tumor cells. However, little is known whether IL-33 and its receptor ST2/IL-1 R4 could regulate trophoblast cells, which are associated with the pathogenesis of PE...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29736153/tabetri%C3%A2-tabebuia-avellanedae-ethanol-extract-ameliorates-atopic-dermatitis-symptoms-in-mice
#10
Jae Gwang Park, Young-Su Yi, Sang Yun Han, Yo Han Hong, Sulgi Yoo, Eunji Kim, Seong-Gu Jeong, Adithan Aravinthan, Kwang Soo Baik, Su Young Choi, Jung-Il Kim, Young-Jin Son, Jong-Hoon Kim, Jae Youl Cho
Tabebuia avellanedae has been traditionally used as an herbal remedy to alleviate various diseases. However, the plant's pharmacological activity in allergic and inflammatory diseases and its underlying mechanism are not fully understood. Therefore, we investigated the pharmacological activity of Tabetri ( T. avellanedae ethanol extract (Ta-EE)) in the pathogenesis of AD. Its underlying mechanism was explored using an AD mouse model and splenocytes isolated from this model. Ta-EE ameliorated the AD symptoms without any toxicity and protected the skin of 2,4-dinitrochlorobenzene- (DNCB-) induced AD mice from damage and epidermal thickness...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29736152/butyrylcholinesterase-levels-on-admission-predict-severity-and-12-month-mortality-in-hospitalized-aids-patients
#11
Lijun Xu, Biao Zhu, Ying Huang, Zongxing Yang, Jia Sun, Yan Xu, Jinlei Zheng, Sabine Kinloch, Michael T Yin, Honglei Weng, Nanping Wu
Background: Butyrylcholinesterase (BChE) is synthesized mainly in the liver and an important marker in many infectious/inflammatory diseases, but its role in acquired immunodeficiency syndrome (AIDS) patients is not clear. We wished to ascertain if BChE level is associated with the progression/prognosis of AIDS patients. Methods: BChE levels (in U/L) were measured in 505 patients; <4500 was defined as "low" and ≥4500 as "normal." Associations between BChE level and CD4 count, WHO stage, body mass index (BMI), C-reactive protein (CRP) level, and duration of hospitalization were assessed...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29725272/the-role-of-regulatory-t-cell-in-nontypeable-haemophilus-influenzae-induced-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#12
Xuewa Guan, Yanjiao Lu, Guoqiang Wang, Peter Gibson, Fang Chen, Keyong Fang, Ziyan Wang, Zhiqiang Pang, Yingqiao Guo, Junying Lu, Yuze Yuan, Nan Ran, Fang Wang
Chronic obstructive pulmonary disease (COPD) is associated with irreversible persistent airflow limitation and enhanced inflammation. The episodes of acute exacerbation (AECOPD) largely depend on the colonized pathogens such as nontypeable Haemophilus influenzae (NTHi), one of the most commonly isolated bacteria. Regulatory T cells (Tregs) are critical in controlling inflammatory immune responses and maintaining tolerance; however, their role in AECOPD is poorly understood. In this study, we hypothesized a regulatory role of Tregs, as NTHi participated in the progress of COPD...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29725271/the-protective-mechanism-of-cay10683-on-intestinal-mucosal-barrier-in-acute-liver-failure-through-lps-tlr4-myd88-pathway
#13
Yao Wang, Hui Chen, Qian Chen, Fang-Zhou Jiao, Wen-Bin Zhang, Zuo-Jiong Gong
The purpose of this study was to investigate the protective mechanism of HDAC2 inhibitor CAY10683 on intestinal mucosal barrier in acute liver failure (ALF). In order to establish ALF-induced intestinal epithelial barrier disruption models, D-galactosamine/LPS and LPS were, respectively, used with rats and NCM460 cell and then administrated with CAY10683. Transepithelial electrical resistance (TEER) was measured to detect the permeability of cells. Real-time PCR and Western blotting were employed to detect the key mRNA and protein levels...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29725270/long-noncoding-rnas-and-mrna-regulation-in-peripheral-blood-mononuclear-cells-of-patients-with-chronic-obstructive-pulmonary-disease
#14
Xiaoyan Qu, Xiaomin Dang, Weijia Wang, Ying Li, Dan Xu, Dong Shang, Ying Chang
Background: Inflammation plays a pivotal role in the pathogenesis of chronic obstructive pulmonary disease (COPD). We evaluated the lncRNA and mRNA expression profile of peripheral blood mononuclear cells (PBMCs) from healthy nonsmokers, smokers without airflow limitation, and COPD patients. Methods: lncRNA and mRNA profiling of PBMCs from 17 smokers and 14 COPD subjects was detected by high-throughput microarray. The expression of dysregulated lncRNAs was validated by qPCR...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29725269/extraction-process-component-analysis-and-in-vitro-antioxidant-antibacterial-and-anti-inflammatory-activities-of-total-flavonoid-extracts-from-abutilon-theophrasti-medic-leaves
#15
Chunlian Tian, Peng Zhang, Caixia Yang, Xiang Gao, Hong Wang, Yuru Guo, Mingchun Liu
The flavonoid fraction was extracted from the leaves of Abutilon theophrasti Medic., which are usually used as a traditional Chinese herbal medicine for the treatment of inflammation and joint pain. The current study focused on the extraction process, component analysis, and in vitro antioxidant, antibacterial, and anti-inflammatory activities of the flavonoid fraction as a part of ongoing research on bioactive substances from natural plant sources. This study evaluated the antioxidant activities via assays of DPPH radical scavenging capacity, ABTS radical scavenging capacity, and reducing power and investigated inhibitory activities against Escherichia coli , Salmonella , Staphylococcus aureus , and Streptococcus ...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29720895/monocyte-chemoattractant-protein-1-in-antineutrophil-cytoplasmic-autoantibody-associated-vasculitis-biomarker-potential-and-association-with-polymorphisms-in-the-mcp-1-and-the-cc-chemokine-receptor-2-gene
#16
Nina Jönsson, Evelina Erlandsson, Lena Gunnarsson, Åsa Pettersson, Sophie Ohlsson
Antineutrophil cytoplasmic autoantibody- (ANCA-) associated vasculitis (AAV) are relapsing-remitting disorders with unpredictable prognosis. There is a need of biomarkers for distinguishing which patients will have a more severe outcome and also for predicting relapses in disease activity. This study confirms the previous results of urinary MCP-1 (uMCP-1) as a prognostic marker and explores its potential as a marker of disease activity. Method . 114 patients with AAV were followed regularly between 2002 and 2011 at Skåne University Hospital...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29720894/pleiotropic-associations-of-rarres2-gene-variants-and-circulating-chemerin-levels-potential-roles-of-chemerin-involved-in-the-metabolic-and-inflammation-related-diseases
#17
Leay-Kiaw Er, Semon Wu, Lung-An Hsu, Ming-Sheng Teng, Yu-Ching Sun, Yu-Lin Ko
Chemerin, an adipokine and inflammatory mediator, is associated with metabolic, inflammation- and immune-mediated diseases. The genetic, clinical, and biomarker correlates of circulating chemerin levels have not been completely elucidated. We analyzed the determinants and correlates of retinoic acid receptor responder 2 ( RARRES2 ; encoding chemerin) gene variants and chemerin levels in the Taiwanese population. In total, 612 individuals were recruited. Clinical and metabolic phenotypes, 13 inflammatory markers, 5 adipokines, and 6 single-nucleotide polymorphisms (SNPs) covering the RARRES2 region were analyzed...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29713241/intestinal-immunomodulatory-cells-t-lymphocytes-a-bridge-between-gut-microbiota-and-diabetes
#18
REVIEW
Qingwei Li, Zezheng Gao, Han Wang, Haoran Wu, Yanwen Liu, Yingying Yang, Lin Han, Xinmiao Wang, Linhua Zhao, Xiaolin Tong
Diabetes mellitus (DM) is one of the most familiar chronic diseases threatening human health. Recent studies have shown that the development of diabetes is closely related to an imbalance of the gut microbiota. Accordingly, there is increasing interest in how changes in the gut microbiota affect diabetes and its underlying mechanisms. Immunomodulatory cells play important roles in maintaining the normal functioning of the human immune system and in maintaining homeostasis. Intestinal immunomodulatory cells (IICs) are located in the intestinal mucosa and are regarded as an intermediary by which the gut microbiota affects physiological and pathological properties...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29713240/il-33-il-31-axis-a-potential-inflammatory-pathway
#19
REVIEW
Eleonora Di Salvo, Elvira Ventura-Spagnolo, Marco Casciaro, Michele Navarra, Sebastiano Gangemi
Cytokines play an important role in the regulation of the immune system (adaptive and innate). Given their importance in proinflammatory processes, cytokines have been used for understanding the pathogenesis and as biomarkers in many diseases. IL-31 and IL-33 are still considered novel cytokines. IL-31 controls signalling and regulates a huge amount of biological functions: it induces proinflammatory cytokines, regulates cell proliferation, and is involved also in tissue remodelling. On the other hand, IL-33 has been identified as an "alarmin" released from the epithelial cells and from different human tissues and organs after a damage following, that is, an inflammatory process...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29713239/oxysterols-increase-inflammation-lipid-marker-levels-and-reflect-accelerated-endothelial-dysfunction-in-experimental-animals
#20
Tomasz Wielkoszyński, Jolanta Zalejska-Fiolka, Joanna K Strzelczyk, Aleksander J Owczarek, Armand Cholewka, Marcin Furmański, Agata Stanek
Objective: Oxidized cholesterol derivatives are thought to exert atherogenic effect thus adversely affecting vascular endothelium. The aim of the study was to assess the effect of 5 α ,6 α -epoxycholesterol on experimentally induced hypercholesterolemia in rabbits, and the levels of homocysteine (HCY), asymmetric dimethylarginine (ADMA), paraoxonase-1 (PON-1), and inflammatory parameters (IL-6, TNF- α , CRP). Material and methods: The rabbits were divided into 3 groups, 8 animals each, and fed with basic fodder (C), basic fodder plus cholesterol (Ch) or basic fodder plus 5 α ,6 α -epoxycholesterol, and unoxidized cholesterol (ECh)...
2018: Mediators of Inflammation
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