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Mediators of Inflammation

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https://www.readbyqxmd.com/read/27890971/veronicastrum-axillare-alleviates-lipopolysaccharide-induced-acute-lung-injury-via-suppression-of-proinflammatory-mediators-and-downregulation-of-the-nf-%C3%AE%C2%BAb-signaling-pathway
#1
Quanxin Ma, Kai Wang, Qinqin Yang, Shun Ping, Weichun Zhao, Qiyang Shou, Weimin Zhou, Minli Chen
Veronicastrum axillare is a traditional medical plant in China which is widely used in folk medicine due to its versatile biological activities, especially for its anti-inflammatory effects. However, the detailed mechanism underlying this action is not clear. Here, we studied the protective effects of V. axillare against acute lung injury (ALI), and we further explored the pharmacological mechanisms of this action. We found that pretreatment with V. axillare suppressed the release of proinflammatory cytokines in the serum of ALI mice...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27890970/enterococcus-faecium-hdrsef1-protects-the-intestinal-epithelium-and-attenuates-etec-induced-il-8-secretion-in-enterocytes
#2
Zhongyuan Tian, Xiaofang Liu, Ran Dai, Yuncai Xiao, Xiliang Wang, Dingren Bi, Deshi Shi
The probiotic Enterococcus faecium HDRsEf1 (Ef1) has been shown to have positive effects on piglet diarrhoea, but the mechanism has not yet been elucidated. In this study, using the IPEC-J2 cell line to mimic intestinal epithelial cells and enterotoxigenic Escherichia coli (ETEC) K88ac as a representative intestinal pathogen, the mechanism underlying Ef1 protection against an enteropathogen was investigated. The results demonstrated that Ef1 was effective in displacing K88ac from the IPEC-J2 cell layer. Moreover, Ef1 and its cell-free supernatant (S-Ef1) modulate IL-8 released by IPEC-J2 cells...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27881904/long-noncoding-rnas-in-metabolic-syndrome-related-disorders
#3
REVIEW
Magdalena Losko, Jerzy Kotlinowski, Jolanta Jura
Ribonucleic acids (RNAs) are very complex and their all functions have yet to be fully clarified. Noncoding genes (noncoding RNA, sequences, and pseudogenes) comprise 67% of all genes and they are represented by housekeeping noncoding RNAs (transfer RNA (tRNA), ribosomal RNA (rRNA), small nuclear RNA (snRNA), and small nucleolar RNA (snoRNA)) that are engaged in basic cellular processes and by regulatory noncoding RNA (short and long noncoding RNA (ncRNA)) that are important for gene expression/transcript stability...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27881903/forskolin-inhibits-lipopolysaccharide-induced-modulation-of-mcp-1-and-gpr120-in-3t3-l1-adipocytes-through-an-inhibition-of-nf%C3%AE%C2%BAb
#4
Jeanne Durendale Chiadak, Tatjana Arsenijevic, Kevin Verstrepen, Françoise Gregoire, Nargis Bolaky, Valérie Delforge, Véronique Flamand, Jason Perret, Christine Delporte
In an obese state, Toll-like receptor-4 (TLR-4) upregulates proinflammatory adipokines secretion including monocyte chemotactic protein-1 (MCP-1) in adipose tissue. In contrast, G-protein coupled receptor 120 (GPR120) mediates antiobesity effects. The aim of this study was to determine the signaling pathway by which Forskolin (FK), a cyclic adenosine monophosphate- (cAMP-) promoting agent causing positive changes in body composition in overweight and obese adult men, affects MCP-1 and GPR120 expression during an inflammatory response induced by lipopolysaccharide (LPS) in adipocytes, such as in an obese state...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27872516/proliferative-effects-of-histamine-on-primary-human-pterygium-fibroblasts
#5
Zhenwei Qin, Qiuli Fu, Lifang Zhang, Houfa Yin, Xiuming Jin, Qiaomei Tang, Danni Lyu, Ke Yao
Purpose. It has been confirmed that inflammatory cytokines are involved in the progression of pterygium. Histamine can enhance proliferation and migration of many cells. Therefore, we intend to investigate the proliferative and migratory effects of histamine on primary culture of human pterygium fibroblasts (HPFs). Methods. Pterygium and conjunctiva samples were obtained from surgery, and toluidine blue staining was used to identify mast cells. 3-[4, 5-Dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) was performed to evaluate the proliferative rate of HPFs and human conjunctival fibroblasts (HCFs); ki67 expression was also measured by immunofluorescence analysis...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27872515/therapeutic-treatment-of-arthritic-mice-with-15-deoxy-%C3%AE-12-14-prostaglandin-j2-15d-pgj2-ameliorates-disease-through-the-suppression-of-th17-cells-and-the-induction-of-cd4-cd25-foxp3-cells
#6
Vanessa Carregaro, Marcelo H Napimoga, Raphael S Peres, Luciana Benevides, Laís Amorim Sacramento, Larissa G Pinto, Renata Grespan, Thiago M Cunha, João Santana da Silva, Fernando Q Cunha
The prostaglandin, 15-deoxy Δ(12,14)-prostaglandin J2 (15d-PGJ2), is a lipid mediator that plays an important role in the control of chronic inflammatory disease. However, the role of prostanoid in rheumatoid arthritis (RA) is not well determined. We demonstrated the therapeutic effect of 15d-PGJ2 in an experimental model of arthritis. Daily administration of 15d-PGJ2 attenuated the severity of CIA, reducing the clinical score, pain, and edema. 15d-PGJ2 treatment was associated with a marked reduction in joint levels of proinflammatory cytokines...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27872514/the-role-of-interleukin-17-in-lung-cancer
#7
REVIEW
Feng Wu, Juanjuan Xu, Qi Huang, Jieli Han, Limin Duan, Jinshuo Fan, Zhilei Lv, Mengfei Guo, Guorong Hu, Lian Chen, Shuai Zhang, Xiaonan Tao, Wanli Ma, Yang Jin
Tumour-associated inflammation is a hallmark of malignant carcinomas, and lung cancer is a typical inflammation-associated carcinoma. Interleukin-17 (IL-17) is an important inflammatory cytokine that plays an important role in chronic inflammatory and autoimmune diseases and in inflammation-associated tumours. Numerous studies have shown that IL-17 directly or indirectly promotes tumour angiogenesis and cell proliferation and that it inhibits apoptosis via the activation of inflammatory signalling pathways...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27872513/vaginal-lactoferrin-modulates-pge2-mmp-9-mmp-2-and-timp-1-amniotic-fluid-concentrations
#8
Alessandro Trentini, Martina Maritati, Carlo Cervellati, Maria C Manfrinato, Arianna Gonelli, Carlo A Volta, Fortunato Vesce, Pantaleo Greco, Franco Dallocchio, Tiziana Bellini, Carlo Contini
Inflammation plays an important role in pregnancy, and cytokine and matrix metalloproteases (MMPs) imbalance has been associated with premature rupture of membranes and increased risk of preterm delivery. Previous studies have demonstrated that lactoferrin (LF), an iron-binding protein with anti-inflammatory properties, is able to decrease amniotic fluid (AF) levels of IL-6. Therefore, we aimed to evaluate the effect of vaginal LF administration on amniotic fluid PGE2 level and MMP-TIMP system in women undergoing genetic amniocentesis...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27867263/interferon-stimulated-gene-15-conjugation-stimulates-hepatitis-b-virus-production-independent-of-type-i-interferon-signaling-pathway-in-vitro
#9
Yujia Li, Shilin Li, Xiaoqiong Duan, Yanzhao Chen, Baihai Jiao, Haiyan Ye, Min Yao, Limin Chen
Hepatitis B virus (HBV) is an important account of infectious hepatitis and interferon (IFN) remains one of the best treatment options. Activation of type I IFN signaling pathway leads to expressions of IFN-stimulated genes (ISGs) which play important roles in antiviral and immunomodulatory responses to HBV or hepatitis C virus (HCV) infection. Our previous studies indicated that ISG15 and its conjugation (ISGylation) were exploited by HCV to benefit its replication and persistent infection. This study was designed to assess the role of ISG15 and ISGylation in HBV infection in vitro...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27847409/effect-of-interleukin-15-on-cd11b-cd54-and-cd62l-expression-on-natural-killer-cell-and-natural-killer-t-like-cells-in-systemic-lupus-erythematosus
#10
Syh-Jae Lin, Ji-Yih Chen, Ming-Ling Kuo, Hsiu-Shan Hsiao, Pei-Tzu Lee, Jing-Long Huang
Adhesion molecules may play an important role in systemic lupus erythematosus (SLE) pathogenesis. We investigated the effect of interleukin- (IL-) 15 on CD11b, CD54, and CD62L expression on natural killer (NK) cells, T cells, and CD56(+)CD3(+) NKT-like cells from SLE subjects and healthy controls. SLE patients had decreased circulating NK cells and NKT-like cells compared to controls. NK cells from SLE patients showed higher CD11b and CD62L expression compared to controls. IL-15 enhanced CD11b and CD54 but downregulated CD62L expression on NK cells from SLE patients...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27847408/herbal-medicines-for-inflammatory-diseases-2016
#11
EDITORIAL
Seong-Gyu Ko, Chang Shik Yin, Bing Du, Kyoung Hyun Kim
No abstract text is available yet for this article.
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27847407/anti-inflammatory-effects-of-traf-interacting-protein-in-rheumatoid-arthritis-fibroblast-like-synoviocytes
#12
Qing-Zhu Kong, Li-Tao Guo, Jia-Ning Yang, Yan-Fei Wang, Jing-Xin Zhao, Su-Hong Kong, Meng Zhang, Shi Yan, Yu Jin
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by inflammatory cell infiltration, synovial inflammation, and cartilage destruction. Proliferative fibroblast-like synoviocytes (FLS) play crucial roles in both propagation of inflammation and joint damage because of their production of great amount of proinflammatory cytokines and proteolytic enzymes. In this study, we investigate the role of TRAF-interacting protein (TRIP) in regulating inflammatory process in RA-FLS. TRIP expression was attenuated in RA-FLS compared with osteoarthritis- (OA-) FLS...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27847406/high-mobility-group-box-1-a-missing-link-between-diabetes-and-its-complications
#13
REVIEW
Han Wu, Zheng Chen, Jun Xie, Li-Na Kang, Lian Wang, Biao Xu
High mobility group box-1 (HMGB-1), a damage-associated molecular pattern, can be actively or passively released from various cells under different conditions and plays a pivotal role in the pathogenesis of inflammation and angiogenesis-dependent diseases. More and more evidence suggests that inflammation, in addition to its role in progression of diabetes, also promotes initiation and development of diabetic complications. In this review, we focus on the role of HMGB-1 in diabetes-related complications and the therapeutic strategies targeting HMGB-1 in diabetic complications...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27847405/in-vitro-anti-inflammatory-effects-of-three-fatty-acids-from-royal-jelly
#14
Yi-Fan Chen, Kai Wang, Yan-Zheng Zhang, Yu-Fei Zheng, Fu-Liang Hu
Trans-10-hydroxy-2-decenoic acid (10-H2DA), 10-hydroxydecanoic acid (10-HDAA), and sebacic acid (SEA) are the three major fatty acids in royal jelly (RJ). Previous studies have revealed several pharmacological activities of 10-H2DA and 10-HDAA, although the anti-inflammatory effects and underlying mechanisms by which SEA acts are poorly understood. In the present study, we evaluated and compared the in vitro anti-inflammatory effects of these RJ fatty acids in lipopolysaccharide-stimulated RAW 264.7 macrophages...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27843203/mir-155-regulated-inflammation-response-by-the-socs1-stat3-pdcd4-axis-in-atherogenesis
#15
Jinshan Ye, Ruiwei Guo, Yankun Shi, Feng Qi, Chuanming Guo, Lixia Yang
Inflammation response plays a critical role in all phases of atherosclerosis (AS). Increased evidence has demonstrated that miR-155 mediates inflammatory mediators in macrophages to promote plaque formation and rupture. However, the precise mechanism of miR-155 remains unclear in AS. Here, we also found that miR-155 and PDCD4 were elevated in the aortic tissue of atherosclerotic mice and ox-LDL treated RAW264.7 cells. Further studies showed that miR-155 not only directly inhibited SOCS1 expression, but also increased the expression of p-STAT and PDCD4, as well as the production of proinflammation mediators IL-6 and TNF-α...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27843202/inflammatory-biomarkers-in-cancer
#16
EDITORIAL
Tomoki Nakamura, Czar L Gaston, Krishna Reddy, Shintaro Iwata, Jun Nishio
No abstract text is available yet for this article.
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27843201/indoxyl-sulfate-induces-mesangial-cell-proliferation-via-the-induction-of-cox-2
#17
Shuzhen Li, Sijie Cheng, Zhenzhen Sun, Harr-Keshauve Mungun, Wei Gong, Jing Yu, Weiwei Xia, Yue Zhang, Songming Huang, Aihua Zhang, Zhanjun Jia
Indoxyl sulfate (IS) is one of important uremic toxins and is markedly accumulated in the circulation of end stage renal disease (ESRD) patients, which might contribute to the damage of residual nephrons and progressive loss of residual renal function (RRF). Thus this study was undertaken to investigate the role of IS in modulating mesangial cell (MC) proliferation and the underlying mechanism. The proliferation of MCs induced by IS was determined by cell number counting, DNA synthase rate, and cell cycle phase analysis...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27843200/mmp8-is-increased-in-lesions-and-blood-of-acne-inversa-patients-a-potential-link-to-skin-destruction-and-metabolic-alterations
#18
Athanasia Tsaousi, Ellen Witte, Katrin Witte, Hans-Joachim Röwert-Huber, Hans-Dieter Volk, Wolfram Sterry, Kerstin Wolk, Sylke Schneider-Burrus, Robert Sabat
Acne inversa (AI; also designated as hidradenitis suppurativa) is a chronic inflammatory disease with still unknown pathogenesis that affects the intertriginous skin of perianal, inguinal, and axillary sites. It leads to painful nodules, abscesses, and fistulas with malodorous secretion and is frequently associated with metabolic alterations. Here, we demonstrate that one of the most highly upregulated molecules in AI lesions is matrix metalloproteinase 8 (MMP8), an enzyme specialized in the degradation of extracellular matrix components and the HDL component apolipoprotein A-I...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27843199/corrigendum-to-sphingosine-1-phosphate-signaling-in-immune-cells-and-inflammation-roles-and-therapeutic-potential
#19
Masayo Aoki, Hiroaki Aoki, Rajesh Ramanathan, Nitai C Hait, Kazuaki Takabe
[This corrects the article DOI: 10.1155/2016/8606878.].
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27843198/regulation-of-autophagy-related-protein-and-cell-differentiation-by-high-mobility-group-box-1-protein-in-adipocytes
#20
Huanhuan Feng, Lili Yu, Guojun Zhang, Guoyan Liu, Can Yang, Hui Wang, Xiangfeng Song
High mobility group box 1 protein (HMGB1) is a molecule related to the development of inflammation. Autophagy is vital to maintain cellular homeostasis and protect against inflammation of adipocyte injury. Our recent work focused on the relationship of HMGB1 and autophagy in 3T3-L1 cells. In vivo experimental results showed that, compared with the normal-diet group, the high-fat diet mice displayed an increase in adipocyte size in the epididymal adipose tissues. The expression levels of HMGB1 and LC3II also increased in epididymal adipose tissues in high-fat diet group compared to the normal-diet mice...
2016: Mediators of Inflammation
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