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Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie

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https://www.readbyqxmd.com/read/28739395/sterigmatocystin-induced-apoptosis-in-human-pulmonary-cells-in-vitro
#1
Jinfeng Cui, Juan Wang, Shujuan Huang, Xiujuan Jiang, Yuehong Li, Wenxin Wu, Xianghong Zhang
Sterigmatocystin (ST) is generally recognized as a potential carcinogen, mutagen and teratogen. Studies showed that ST could induce adenocarcinoma of lung in mice in vivo and DNA damage, cell cycle arrest in a human immortalized bronchial epithelial cell line (BEAS-2B cells) and a human lung cancer cell line (A549 cells) in vitro. Besides, ST could induce G2 arrest (cell cycle arrest in G2 phase) in several other cells. Cell cycle arrest may be one of the common toxic effects of ST. As cells may undergo apoptosis or death due to cell cycle arrest, we wondered whether apoptosis is another common effect of ST in different cells in vitro...
July 21, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28739394/ameliorative-effect-of-%C3%AE-tocopherol-on-polychlorinated-biphenyl-pcbs-induced-testicular-sertoli-cell-dysfunction-in-f1-prepuberal-rats
#2
Sugantha Priya Elayapillai, Dhanaraj Teekaraman, Raja Singh Paulraj, Arunakaran Jagadeesan
The study was conducted to investigate the protective role of α-tocopherol against polychlorinated biphenyls (PCBs) induced effect in Sertoli cell function of F1 prepuberal rats. Dams were grouped into six; each group consists of six animals. Group 1-control treated with corn oil as vehicle, group II- 0.5mgPCBs/kg bw/day, group III- 0.5mgPCBs/kg bw/day with α-tocopherol (50mg α-tocopherol/kg bw/day), group IV- 1mgPCBs/kg bwt/day, group V- 1mgPCBs/kg bw/day with α-tocopherol (50mg α-tocopherol/kg bw/day) and group VI - α-tocopherol alone treated orally from postpartum day1-20...
July 21, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28684087/anti-arthritic-potential-of-marine-macroalgae-turbinaria-ornata-in-complete-freund-s-adjuvant-induced-rats
#3
S Ananthi, V Gayathri, R Malarvizhi, Meenakshi Bhardwaj, Hannah R Vasanthi
T. ornata a macroalgae rich in bioactive molecules possess various biological activities. Herein, the aim of the study is to evaluate the aqueous extract and the sulphated polysaccharide isolated from T. ornata for its anti-arthritic potential in Complete Freund's Adjuvant (CFA) induced arthritis in rats. Anti-arthritic potential of aqueous T. ornata (ATO) and T. ornata sulphated polysaccharide (TSP) was evidenced by the significant reduction in paw volume and arthritic score. Inflammatory and antioxidant markers were found to be restored in the drug treated groups which was found to be in line with dexamethasone a standard anti-inflammatory drug...
July 3, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28655429/a-study-of-the-correlation-between-ultrafine-particle-emissions-in-motorcycle-smoke-and-mice-erythrocyte-damages
#4
Arinto Y P Wardoyo, Unggul P Juswono, Johan A E Noor
Sharply increasing of motor vehicles every year contributes to amounts of ultrafine particles (UFPs) in the air. Besides, the existence of UFPs in the blood may cause erythrocyte damages that subject to shape deformation. This study was aimed to investigate the influence of UFPs in the motorcycle smoke exposed to mice in different concentrations to the erythrocyte damages. The experiments were conducted by injecting the motorcycle smoke with the varied amounts in an experimental chamber (dimension of 30×20×20cm(3)) where the mice were put in advance for exposuring twice a day (100s)...
June 24, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28648614/the-effects-of-retinoic-acid-on-mmp-2-production-proliferation-and-ultrastructural-morphology-in-rat-uterus
#5
Tuğba Kotil, Şengül Şentürk, Türkan Sarioğlu, Leyla Tapul
AIMS: Retinoic acid (RA) has a vital importance in order to ensure continuity and morphology in many tissues. Matrix metalloproteinases (MMPs) have significant roles in proliferation, the formation of cancers, and metastasis. In this study the effects of RA on MMP-2 production in cells of rat uterus were investigated. METHODS: Twenty-four adult Spraque Dawley rats were divided into two groups, the experimental group was treated with 40mg/kg/day 13-cis RA for 5days by gavage...
June 22, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28645882/cardiopreventive-effect-of-ethanolic-extract-of-date-palm-pollen-against-isoproterenol-induced-myocardial-infarction-in-rats-through-the-inhibition-of-the-angiotensin-converting-enzyme
#6
Amal Daoud, Fedia Ben Mefteh, Kais Mnafgui, Mouna Turki, Salwa Jmal, Rawdha Ben Amar, Fatma Ayadi, Abdelfattah ElFeki, Leila Abid, Mostafa E Rateb, Lassaad Belbahri, Adel Kadri, Neji Gharsallah
The present study aimed to examine the putative preventive effect of the ethanolic extract Date Palm Pollen (DPP, Phoenix dactylifera L., family Arecaceae) on isoproterenol-induced myocardial infarction (MI) in rats. Twenty four rats were randomly divided into four groups including control. They were treated with DPP extract (400mg/kg) and clopidogrel (0.2mg/kg) for 7days followed by myocardial injury induction using subcutaneous isoproterenol (100mg/kg) with an interval of 24h for two days (6th and 7th day)...
June 20, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28619518/in-vitro-cytotoxic-potential-of-friedelin-in-human-mcf-7-breast-cancer-cell-regulate-early-expression-of-cdkn2a-and-prb1-neutralize-mdm2-p53-amalgamation-and-functional-stabilization-of-p53
#7
Pandurangan Subash-Babu, David K Li, Ali A Alshatwi
We aimed to explore the cytotoxic and apoptotic effect of friedelin on breast cancer MCF-7 cells. Cytotoxic effect of friedelin on MCF-7 cells was analyzed using MTT, cell and nuclear morphology. The apoptosis mechanism of friedelin on MCF-7 cells was analyzed using real-time PCR. Friedelin potentially inhibit 78% of MCF-7 cell's growth, the IC50 value was 1.8μM in 24h and 1.2μM in 48h. Friedelin increased ROS significantly and DNA damage was confirmed by tunel assay. We found characteristically 52% apoptotic cells and 6% necrotic cells in PI, AO/ErBr staining after 48h treatment with 1...
June 12, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28602391/validating-the-use-of-napsin-a-as-a-marker-for-identifying-tumorigenic-potential-of-lung-bronchiolo-alveolar-hyperplasia-in-rodents
#8
Masanao Yokohira, Yuko Nakano-Narusawa, Keiko Yamakawa, Nozomi Hashimoto, Shota Yoshida, Shohei Kanie, Katsumi Imaida
There are two types of bronchiolo-alveolar hyperplasia (hyperplasia) in rodent lungs. The first is "inflammatory hyperplasia" that retains its ability to revert to normal epithelia upon removal of the stimulating insult. The second is "latent tumorigenic hyperplasia", which is irreversible and causes independent preneoplastic lesions that can progress to bronchiolo-alveolar adenocarcinoma. Previously, lung samples with hyperplastic lesions were obtained from rats exposed to N-bis (2-hydroxypropyl) nitrosamine (DHPN) and fine particles (e...
June 8, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28602390/a-study-on-role-of-triiodothyronine-t3-hormone-on-the-improvement-of-articular-cartilage-surface-architecture
#9
Pei-Tong Jia, Xing-Lin Zhang, Hai-Ning Zuo, Xing Lu, Peng-Zhou Gai
The present study was aimed to investigate the effect of triiodothyronine (T3) on the improvement of articular cartilage surface architecture at in vitro level. The T3 hormone was applied to neo-tissues in the range of 50, 100, 150 and 200ng/ml for 5 weeks. At the end of the treatment, biochemical and histological evaluation was carried out in the neo-tissues. T3 hormone application significantly increased the collagen production in neo-cartilage tissues. The properties of tensile and compressive were significantly increased compared to the controls...
June 8, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28599809/hepatoprotective-effect-of-chitosan-caffeic-acid-conjugate-against-ethanol-treated-mice
#10
Soo Yeon Park, Ginnae Ahn, Ju Hyung Um, Eui Jeong Han, Chang-Bum Ahn, Na Young Yoon, Jae-Young Je
The chitosan-caffeic acid (CCA) conjugate shows a hepatoprotective effect against oxidative stress-induced hepatic damage in cultured hepatocytes. The objective of this study is the verification of the hepatoprotective effect of the CCA in vivo against ethanol-induced liver injury in mice. The administration of ethanol resulted in the increase of the serum-aminotransferase activities (AST and ALT), triglycerides, total cholesterol, and lipid peroxidation. The CCA co-administration, however, significantly (p<0...
June 6, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28587827/combined-effects-of-deoxynivalenol-and-zearalenone-on-oxidative-injury-and-apoptosis-in-porcine-splenic-lymphocytes-in-vitro
#11
Zhihua Ren, Huidan Deng, Youtian Deng, Zhen Liang, Junliang Deng, Zhicai Zuo, Yanchun Hu, Liuhong Shen, Shumin Yu, Suizhong Cao
Deoxynivalenol (DON) and zearalenone (ZEA) are the two most common mycotoxins in animal feed. In this study, we examined oxidative injury and apoptosis of porcine splenic lymphocytes induced by DON or ZEA and their combination in vitro. Based on IC50 values, porcine splenic lymphocytes were treated with 0.06, 0.3, 1.5, and 7.5μg/mL DON, 0.08, 0.4, 2, and 10μg/mL ZEA, or both DON and ZEA at 0.06 and 0.08μg/mL, 0.3 and 0.4μg/mL, and 1.5 and 2μg/mL, respectively. After 48h of DON and/or ZEA exposure, the cells were analyzed for antioxidant functions, apoptosis, and mRNA and protein expression of apoptosis-related genes p53, Bcl-2, Bax, caspase-3, and caspase-8 to determine their apoptosis and oxidative damage effects and mechanisms...
June 3, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28583699/stem-cell-therapy-with-skeletal-myoblasts-accelerates-neointima-formation-in-a-mouse-model-of-vein-graft-disease
#12
Christina Maria Steger, Johannes Bonatti, Ralf Joachim Rieker, Nikolaos Bonaros, Thomas Schachner
Although still a matter of controversial discussion, skeletal myoblasts are one of the options for stem cell transplantation improving cardiac function after myocardial infarction, exhibiting several advantages including the availability, the ability of self-renewal and differentiation, and the lack of ethical and immunological problems. The aim of this study was to investigate the impact of stem cell therapy with skeletal myoblasts on experimental venous bypass grafts in a mouse model of vein graft disease...
June 2, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28559049/attenuation-of-thioacetamide-induced-hepatocellular-injury-by-short-term-repeated-injections-associated-with-down-regulation-of-metabolic-enzymes-and-relationship-with-mhc-class-ii-presenting-cells
#13
Mizuki Kuramochi, Takeshi Izawa, Munmun Pervin, Alexandra Bondoc, Mitsuru Kuwamura, Jonathan LaMarre, Jyoji Yamate
The liver is the primary organ participating in the metabolism of xenobiotics and is therefore an important target in the safety assessment of drugs, chemicals and environmental toxins. Drug-induced liver injury (DILI) has recently become widely recognized in human medicine as an adverse event. The progression of DILI often involves "damage-associated molecular patterns" (DAMPs) of gene and protein expression such as high-mobility group boxes (HMGBs), S100 proteins and heat shock proteins (Hsp). DAMPs are released from injured or necrotic cells and are bound to Toll-like receptors (TLRs) and modulate inflammatory reactions...
May 27, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28554820/argininic-acid-alters-markers-of-cellular-oxidative-damage-in-vitro-protective-role-of-antioxidants
#14
Daniela Delwing-de Lima, Simone Sasso, Leticia Dalmedico, Débora Delwing-Dal Magro, Eduardo Manoel Pereira, Angela T S Wyse
We, herein, investigated the in vitro effects of argininic acid on thiobarbituric acid-reactive substances (TBA-RS), total sulfhydryl content and on the activities of antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the blood, kidney and liver of 60-day-old rats. We also verified the influence of the antioxidants (each at 1.0mM) trolox and ascorbic acid, as well as of N(G)-nitro-l-arginine methyl ester (L-NAME) at 1.0mM, a nitric oxide synthase inhibitor, on the effects elicited by argininic acid on the parameters tested...
May 26, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28552630/protective-effects-of-melatonin-on-long-term-administration-of-fluoxetine-in-rats
#15
Majid Khaksar, Ahmad Oryan, Mansour Sayyari, Aysa Rezabakhsh, Reza Rahbarghazi
The degree and consequence of tissue injury are highly regarded during long-term exposure to selective antidepressant fluoxetine. Melatonin has been shown to palliate different lesions by scavenging free radicals, but its role in the reduction of the fluoxetine-induced injuries has been little known. Thirty-six mature male Wistar rats were randomly assigned into control and experimental groups. The experimental rats were included as following; 24mg/kg/bw fluoxetine for 4 weeks; 1mg/kg/bw melatonin for 4 weeks; fluoxetine+1-week melatonin, fluoxetine+2-week melatonin and fluoxetine+4-week melatonin...
May 25, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28552629/clinical-and-pathological-analysis-of-19-cases-of-medullary-thyroid-carcinoma-without-an-increase-in-calcitonin
#16
Qiufeng Zhou, Shuanglei Yue, Ye Cheng, Ju Jin, Haimiao Xu
BACKGROUND: Medullary thyroid carcinoma (MTC), defined as a malignant tumour with C-cell differentiation, is of neuroendocrine origin and is characterized by the synthesis and secretion of calcitonin (CT). MTC without CT secretion has been reported on rare occasions. The purpose of this study was to evaluate the histological, immunohistochemical, and molecular pathologic features as well as the clinical significance of non-secretory MTC (NCR-MTC). METHODS: A retrospective analysis of patients with NCR-MTC was performed...
May 25, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28552628/effects-of-pcb-126-on-aryl-hydrocarbon-receptor-ubiquitin-and-p53-expression-levels-in-sparus-aurata
#17
M Calò, P Licata, A Bitto, P Lo Cascio, F Giarratana, D Altavilla
The aim of the present study is to determine if Ahr ligands as PCB-126, a dioxin-like, might contribute to inhibition of the tumor suppressor p53 by promoting its degradation through proteasome-ubiquitin system (UPS). The findings show, in the presence of PCB-126, a significant increase of p53 immunoreactivity in fish compared to the control. Subsequently, there is a decrease of p53 immunoreactivity at 24h which is maintained even at 72h. At the same time there is a slight decrease of ubiquitin immunoreactivity to 12h compared to the control and a marked decrease to 24 and 72h...
May 25, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28551406/protective-effect-of-hesperidin-and-tiger-nut-against-acrylamide-toxicity-in-female-rats
#18
Soha M Hamdy, Amany M Shabaan, Abdel Karim M Abdel Latif, Ayman M Abdel-Aziz, Alshimaa M Amin
Phytochemicals that have antioxidant effect play important role in protection against several diseases in humans. This study was carried out to evaluate the efficacy of hesperidin and tiger nut against the early changes that may be related to the toxicity of acrylamide in female rats. 72 Sprague Dawley female rats were divided into six groups (12 rat/group): control group (I); hesperidin (HES) treated group (II); tiger nut (TN) treated group (III); Acrylamide (ACR) treated group (IV); HES-ACR treated group (V); and TN-ACR treated group (VI)...
May 24, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28535907/suppression-of-epithelial-restitution-using-an-inhibitor-against-rho-associated-coiled-coil-containing-protein-kinase-aggravates-colitis-through-reduced-epithelial-expression-of-a-kinase-anchor-protein-13
#19
Yumi Kangawa, Toshinori Yoshida, Yutaka Yonezawa, Kiyoshi Maruyama, Shim-Mo Hayashi, Makoto Shibutani
In the gastrointestinal tract, the immediate healing response to mucosal damage is critical to sustain mucosal homeostasis. The migration of surrounding epithelial cells to cover the denuded area without proliferation is termed restitution, followed by early reparation of the damage. In this study, we determined the role of A-kinase anchor protein 13 (AKAP13) in mice with dextran sulphate sodium (DSS)-induced colitis upon mucosal injury and restitution, and investigated whether inhibition of Rho-associated coiled-coil containing protein kinase (ROCK), downstream effector of AKAP13, affects these mucosal responses...
May 20, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28522248/adverse-effects-in-kidney-function-antioxidant-systems-and-histopathology-in-rats-receiving-monosodium-glutamate-diet
#20
María Del Carmen Contini, Ana Fabro, Néstor Millen, Adriana Benmelej, Stella Mahieu
We investigated the effects of adding of monosodium glutamate (MSG) to a standard diet on oxidative stress in kidney, nitric oxide excretion, renal ions handling and blood pressure. We examined the association of these changes with the effects on renal histology. The study was performed on male Wistar rats (5 weeks old) divided into 3 groups: 1) MSG group were fed a diet supplemented with 3g of MSG/kg b.w./day, five days a week, and spontaneous ingestion of a 1% MSG solution during 16 weeks; 2) NaCl group were fed a diet with NaCl (1g/kg b...
May 15, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
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