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Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie

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https://www.readbyqxmd.com/read/28216169/cytogenotoxicological-defense-of-retinyl-palmitate-in-the-front-damage-of-antineoplastics
#1
Ricardo Melo de Carvalho, Rai Pablo de Sousa Aguiar, Muhammad Torequl Islam, Marcus Vinicius Oliveira Barros de Alencar, Ana Maria Oliveira Ferreira da Mata, Antonio Lima Braga, Josemar José da Silva Júnior, Leonardo da Rocha Sousa, Rosália Maria Tôrres de Lima, Márcia Fernanda Correia Jardim Paz, João Marcelo de Castro E Sousa, Ana Amélia de Carvalho Melo-Cavalcante
Cancer, the multifactorial pathology and to date is the most lethal causes of death in the world. Cyclophosphamide (CPA) and doxorubicin (DOX) are the individually or combindly used two anticancer drugs. The antineoplastic drugs-mediated genetic instability can be overcome by using antioxidants. The study evaluated the cytogenotoxic modulatory potentials of retinyl palmitate (RP) caused by CPA and DOX in Swiss mice. For this, adult Mus musculus of either sex were divided equally regarding to the gender. Toxicogenetic effects were induced by the intraperitoneal (i...
February 16, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28215571/oral-administration-of-nigella-sativa-oil-ameliorates-the-effect-of-cisplatin-on-brush-border-membrane-enzymes-carbohydrate-metabolism-and-antioxidant-system-in-rat-intestine
#2
Faaiza Shahid, Zeba Farooqui, Sana Rizwan, Subuhi Abidi, Iqbal Parwez, Farah Khan
Cisplatin (CP) is an effective chemotherapeutic agent that induces gastrointestinal toxicity. Nigella sativa oil (NSO) has been shown to be beneficial in a wide range of gastrointestinal disorders. The present study investigates the possible protective effect of NSO on CP-induced gastrointestinal toxicity. NSO administration (2ml/kg bwt, orally), prior to and following, a single dose CP treatment (6mg/kg bwt. ip), significantly attenuated the CP-induced decrease in brush border membrane (BBM) enzyme activities in intestinal homogenates and BBM vesicles (BBMV)...
February 15, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28190563/pathological-and-biochemical-evaluation-of-coumarin-and-chlorophyllin-against-aflatoxicosis-in-rat
#3
Mohamed S Abdel-Latif, Khaled M Elmeleigy, Tahany A A Aly, Marwa S Khattab, Sara M Mohamed
Aflatoxin contamination of animal diet has adverse effects on animal health and productivity. This study was performed to investigate the effect of using coumarin and/or chlorophyllin in rat diet against aflatoxicosis. Fifty-four rats were assigned into 7 groups (6 rats each). G1 was a negative control. G2 received water with coumarin 0.5%. G3 received water with chlorophyllin 0.5%. G4 received water with coumarin 0.5% and chlorophyllin 0.5%. G5-8 fed aflatoxin B1 1000ppb in diet. Group 6-8 were administered similar treatments as G2-4...
February 9, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28190562/a-combined-approach-to-early-detect-in-vitro-drug-induced-hemostatic-changes-in-preclinical-safety
#4
Myriam Defontis, Serge Côté, David Ledieu
Early detection of drug-induced alterations of hemostasis is challenging. Drugs can affect different components of the Virchow's triad and measurement of plasmatic coagulation times lacks sensitivity. New techniques for a more global assessment of the hemostasis are now available: the impedance platelet aggregometry, the thromboelastography and the thrombin generation measurement. The aim of this study was to evaluate three techniques (i.e.: Multiplate(®), TEG(®) and CAT) for the in vitro detection of the effect of a drug known to induce hemostatic alterations in a preclinical safety environment...
February 9, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28189473/effects-of-copper-on-viability-and-functional-properties-of-hippocampal-neurons-in-vitro
#5
Marina R Kapkaeva, Olga V Popova, Rodion V Kondratenko, Pavel D Rogozin, Elisaveta E Genrikhs, Elena V Stelmashook, Vladimir G Skrebitsky, Leonid G Khaspekov, Nickolay K Isaev
Copper (Cu(2+)) is an essential metal presented in the mammalian brain and released from synaptic vesicles following neuronal depolarization. However, the disturbance of Cu(2+) homeostasis results in neurotoxicity. In our study we performed for the first time a combined functional investigation of cultured hippocampal neurons under Cu(2+) exposure, its effect on spontaneous spike activity of hippocampal neuronal network cultured on multielectrode array (MEA), and development of long-term potentiation (LTP) in acute hippocampal slices in the presence of Cu(2+)...
February 8, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28189472/the-potential-protective-role-of-taurine-against-5-fluorouracil-induced-nephrotoxicity-in-adult-male-rats
#6
Hany N Yousef, Hanaa R Aboelwafa
Nephrotoxicity is common with the use of the chemotherapeutic agent 5-Fluorouracil (5-FU). The current study aimed to investigate the probable protective effect of taurine (TAU) against 5-FU-induced nephrotoxicity in rats using biochemical, histological and ultrastructural approaches. Twenty-four rats were equally divided into control, TAU, 5-FU and 5-FU+TAU groups. 5-FU significantly elevated levels of blood urea nitrogen (BUN), creatinine, and uric acid; while it reduced activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px)...
February 8, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28185787/progression-of-renal-fibrosis-in-congenital-ckd-model-rats-with-reduced-number-of-nephrons
#7
Hidenori Yasuda, Yuki Tochigi, Kentaro Katayama, Hiroetsu Suzuki
A congenital reduction in the number of nephrons is a critical risk factor for both onset of chronic kidney disease (CKD) and its progression to end-stage kidney disease (ESKD). Hypoplastic kidney (HPK) rats have only about 20% of the normal number of nephrons and show progressive CKD. This study used an immunohistological method to assess glomerular and interstitial pathogenesis in male HPK rats aged 35-210days. CD68 positive-macrophages were found to infiltrate into glomeruli in HPK rats aged 35 and 70days and to infiltrate into interstitial tissue in rats aged 140 and 210days...
February 6, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28161190/a-spontaneous-high-grade-undifferentiated-mammary-carcinoma-in-a-seven-week-old-female-rat
#8
Ana I Faustino-Rocha, Adelina Gama, Paula A Oliveira, Antonieta Alvarado, Rita Ferreira, Mário Ginja
The present work describes a rare case of a spontaneous high-grade carcinoma in a seven-week-old Sprague-Dawley female rat that had been included in the control group of an assay of mammary carcinogenesis. The mass was detected at 50days of age, it grown quickly and the animal was humanely sacrificed eight days later. The tumor was located in the left cervical region, in the vicinity of the left submandibular and sublingual glands. It was soft and reddish and had several dens with a bloody content. The tumor was PAS negative and exhibited immunostaining for ER-α...
February 1, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28159300/attenuation-of-alpha-naphthylisothiocyanate-anit-induced-biliary-fibrosis-by-depletion-of-hepatic-macrophages-in-rats
#9
Hossain M Golbar, Takeshi Izawa, Alexandra Bondoc, Kavindra K Wijesundera, Anusha H Tennakoon, Mitsuru Kuwamura, Jyoji Yamate
Biliary fibrosis is a complex process in which macrophages and myofibroblasts may play central roles. We investigated biliary fibrosis lesions induced in the Glisson's sheath in rats by alpha-naphthylisothiocyanate (ANIT) administration under macrophage depletion. Hepatic macrophages were depleted in F344 rats with liposome-encapsulated clodronate (CLD) (10mL/kg body weight, i.v) followed by bile duct injury with ANIT (75mg/kg body weight, i.p) (ANIT+CLD group). Rats received empty-liposomes (Lipo) followed by ANIT, and served as control (ANIT+Lipo group)...
January 31, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28153389/gold-nanoparticles-ameliorate-acetaminophen-induced-hepato-renal-injury-in-rats
#10
Mohd Salim Reshi, Sadhana Shrivastava, Amita Jaswal, Neelu Sinha, Chhavi Uthra, Sangeeta Shukla
Valuable effects of gold particles have been reported and used in complementary medicine for decades. The aim of this study was to evaluate the therapeutic efficacy of gold nanoparticles (AuNPs) against acetaminophen (APAP) induced toxicity. Albino rats were administered APAP at a dose of 2g/kg p.o. once only. After 24h of APAP intoxication, animals were treated with three different doses of AuNPs (50μg/kg, 100μg/kg, 150μg/kg) orally or silymarin at a dose of 50mg/kg p.o., once only. Animals of all the groups were sacrificed after 24h of last treatment...
January 30, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28153388/short-term-and-long-term-models-of-doxorubicin-induced-cardiomyopathy-in-rats-a-comparison-of-functional-and-histopathological-changes
#11
João Lucas O'Connell, Minna Moreira Dias Romano, Erica C Campos Pulici, Eduardo E V Carvalho, Fernanda R de Souza, Denise M Tanaka, Benedito Carlos Maciel, Hélio C Salgado, Rubens Fazan-Júnior, Marcos A Rossi, Marcus V Simões
OBJECTIVES: Doxorubicin (DXR), an anthracyclic antineoplastic agent, is one of the most commonly drug utilized to induce dilated cardiomyopathy (DCM) and heart failure (HF), but the well optimized protocol for cardiomyopathy induction leading to development of cardiac systolic dysfunction is unclear. This study aims to critically compare short-term and long-term DXR injection protocols for the induction of DCM in rats. METHODS: Animals were allocated into 3 experimental groups: a ST (short-term DXR injection) group, in which animals received 6 intraperitoneal (i...
January 30, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28132802/the-ability-of-hesperidin-compared-to-that-of-insulin-for-preventing-osteoporosis-induced-by-type-i-diabetes-in-young-male-albino-rats-a-histological-and-biochemical-study
#12
Azza Saad Shehata, Mona Gomah Amer, Manal Reda Abd El-Haleem, Rehab Ahmed Karam
BACKGROUND: Patients with type I diabetes are at increased risk of osteoporosis even after insulin therapy in adult stage. This study was conducted to compare the efficacy of hesperidin (hesp) therapy versus that of insulin alone in the alleviation of osteoporosis arising from type I diabetes mellitus (T1DM) in young rats. MATERIALS AND METHODS: Hesperidin was administered orally to STZ-induced diabetes. The animals were evaluated morphologically and biochemically and compared with that received daily SC injections of long-acting insulin...
January 26, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28126209/hepatotoxicity-induced-by-radix-sophorae-tonkinensis-in-mice-and-increased-serum-cholinesterase-as-a-potential-supplemental-biomarker-for-liver-injury
#13
Liping Wang, Jinyao Lu, Wei Sun, Yingmin Gu, Chaochao Zhang, Ruomin Jin, Lingyong Li, Zean Zhang, Xuesong Tian
Radix Sophorae tonkinensis (S. tonkinensis) is used in Chinese folk medicine to treat sore throats, viral hepatitis, and jaundice. However, little is known about the hepatotoxicity induced by it. This study is to investigate hepatotoxicity induced by radix S. tonkinensis and a potential supplemental biomarker for liver injury through acute toxicity, accumulative toxicity, tolerance test, and sub-chronic toxicity. The contents of cytisine (CYT), matrine (MT), and oxymatrine (OMT) in radix S. tonkinensis extracts were determined simultaneously by the method we developed...
January 23, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28108073/reference-control-data-obtained-from-an-in-vivo-comet-micronucleus-combination-assay-using-sprague-dawley-rats
#14
Sawako Kasamoto, Shoji Masumori, Jin Tanaka, Maya Ueda, Masahito Fukumuro, Miho Nagai, Jyoji Yamate, Makoto Hayashi
According to the International Conference on Harmonization Guidance on Genotoxicity Testing and Data Interpretation for Pharmaceuticals Intended for Human Use (ICH S2(R1)), a positive response in any in vitro assay necessitates additional in vivo test(s) (other tissue/endpoint) in addition to the erythrocyte micronucleus test when Option 1 of the test battery is selected. When Option 2 of the test battery is selected, a bacterial gene mutation test and two in vivo tests with different tissues/endpoint are required...
January 17, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28089463/anti-inflammatory-effects-of-the-selective-phosphodiesterase-3-inhibitor-cilostazol-and-antioxidants-enzymatically-modified-isoquercitrin-and-%C3%AE-lipoic-acid-reduce-dextran-sulphate-sodium-induced-colorectal-mucosal-injury-in-mice
#15
Yumi Kangawa, Toshinori Yoshida, Hajime Abe, Yoshiki Seto, Taishi Miyashita, Michi Nakamura, Tohru Kihara, Shim-Mo Hayashi, Makoto Shibutani
Developing effective treatments and preventing inflammatory bowel disease (IBD) are urgent challenges in improving patients' health. It has been suggested that platelet activation and reactive oxidative species generation are involved in the pathogenesis of IBD. We examined the inhibitory effects of a selective phosphodiesterase-3 inhibitor, cilostazol (CZ), and two antioxidants, enzymatically modified isoquercitrin (EMIQ) and α-lipoic acid (ALA), against dextran sulphate sodium (DSS)-induced colitis. BALB/c mice were treated with 0...
January 12, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28077256/montivipera-bornmuelleri-venom-selectively-exhibits-high-cytotoxic-effects-on-keratinocytes-cancer-cell-lines
#16
Saly Sawan, Tania Yaacoub, Souad Hraoui-Bloquet, Riyad Sadek, Walid Hleihel, Ziad Fajloun, Marc Karam
CONTEXT: The Viperidae family venom is a rich source of bioactive compounds such as many proteases, which cause tissue necrosis and affect mostly the vascular system. However, the venom exhibits therapeutic potentials and has contributed to the development of some medical drugs. Specifically, the Montivipera bornmuelleri venom has shown to exhibit antibacterial, pro-inflammatory and antifungal activities. OBJECTIVE: This work evaluates the cytotoxic effect of the M...
January 8, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28073664/extract-of-bulbus-fritillaria-cirrhosa-perturbs-spindle-assembly-checkpoint-induces-mitotic-aberrations-and-genomic-instability-in-human-colon-epithelial-cell-line
#17
Xihan Guo, Juan Ni, Jinglun Xue, Xu Wang
BACKGROUND: Bulbus Fritillaria cirrhosa D. Don (BFC) has been used in China as a folk medicine for the treatment of cough and asthma for more than 2000 years. The antitussive and antiasthmatic effects of BFC have been reported before, nevertheless its toxicity and safety have not been documented. This study investigated the possible effects of BFC on spindle assembly checkpoint (SAC), mitotic fidelity and genomic stability in human NCM460 colon epithelial cells. METHODS: Cells were treated with BFC (0, 20, 40, 80 and 160μg/ml) for 24, 48 and 72h and harvested differently according to the biomarkers observed...
January 7, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28063643/protective-effect-of-tritone-livosone-on-oxidative-dna-damage-and-its-hepatoprotective-potential-against-various-hepatotoxic-agent-in-wistar-rats
#18
Sheetal Kashinath Medhekar, Tejas Pandurang Jadhav, Vishal Sadashiv Sasane, Vikas Suresh Shende, Nagesh Hanmantrao Aloorkar, Anjali Baburao Chincholkar, Girish Sudhakar Soman, Ajit Shankarrao Kulkarni
AIM: To evaluate antioxidant activity, DNA damage inhibition and hepatoprotecitve potential of polyherbal formulation Tritone (Livosone). METHODS: In vitro antioxidant activity of Tritone formulation was performed by using DPPH assay. Hepatoprotecitve potential of Tritone was evaluated against various hepatotoxic agents including Paracetamol (2g/kg b. wt p.o. single dose on 15th day), Galactosamine (400mg/kg b. wt. i.p. single dose on 8th day) and Alcohol (30% p...
January 4, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28024668/potential-risks-of-maternal-administration-of-mucophylline-on-the-pups-of-albino-rats-during-lactation
#19
Hamida Hamdi, Heba Ali
The present study was undertaken to evaluate the potential risks of the mucolytic and broncholytic drug, Theophylline derivatives (Mucophylline) maternally administered on the pups. The nursing rats orally administered from 1st postpartum day (PPD) to 21th PPD with two different doses 30.83mg/kg (low dose) and 66.61mg/kg (Human equivalent dose (HED)). On the 21th PPD, the postnatal developmental signs, skeletal malformation and the histopathology of neonatal liver, kidney and brain were examined. Our results showed that Mucophylline induced a significant reduction in the neonatal weight and length, delayed, weak and incomplete ossification, wavy ribs and the neonatal liver revealed histopathological changes, pyknotic hepatocytes, cytoplasmic vacuolization, dilated sinusoid and necrotic area...
December 23, 2016: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/27989570/the-effect-of-tannic-acid-on-the-bone-tissue-of-adult-male-wistar-rats-exposed-to-cadmium-and-lead
#20
Ewa Tomaszewska, Piotr Dobrowolski, Anna Winiarska-Mieczan, Małgorzata Kwiecień, Agnieszka Tomczyk, Siemowit Muszyński
Toxic elements such as cadmium (Cd) and lead (Pb) accumulate to the largest extent in bones. Rats at the age of 12 weeks were used to check whether tannic acid (TA) at the concentration of 0.5%, 1.0%, 1.5%. 2.0% or 2.5% would have a protective effect on the structure and properties of bones in the case of exposure to Cd and Pb (diet: 7mg Cd/kg and 50mg Pb/kg) for 12 weeks. The effects of administration of TA in Cd- and Pb-poisoned rats on bone mechanical and geometric properties, trabecular histomorphometry as well as the morphology of articular and growth cartilages were determined...
December 15, 2016: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
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