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Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine

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https://www.readbyqxmd.com/read/30225625/correction-to-iron-metabolism-in-diabetes-induced-alzheimer-s-disease-a-focus-on-insulin-resistance-in-the-brain
#1
Ji Yeon Chung, Hyung-Seok Kim, Juhyun Song
Due to a technical error, the copyright line of the above mentioned article was incorrect. The original publication has been corrected.
September 17, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30136243/lfchimera-protects-hela-cells-from-invasion-by-yersinia-spp-in-vitro
#2
Tjitske Sijbrandij, Antoon J Ligtenberg, Kamran Nazmi, Petra A M van den Keijbus, Enno C I Veerman, Jan G M Bolscher, Floris J Bikker
Yersinia pestis is the causative agent of plague. As adequate antibiotic treatment falls short and currently no effective vaccine is available, alternative therapeutic strategies are needed. In order to contribute to solving this problem we investigated the therapeutic potential of the peptide construct LFchimera against the safer-to-handle Y. pestis simulants Yersinia enterocolitica and Yersinia pseudotuberculosis in vitro. LFchimera is a heterodimeric peptide construct mimicking two antimicrobial domains of bovine lactoferrin, i...
August 22, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30132273/differential-heme-mediated-modulation-of-deinagkistrodon-dispholidus-protobothrops-and-pseudonaja-hemotoxic-venom-activity-in-human-plasma
#3
Vance G Nielsen, Nathaniel Frank
Envenomation by vipers with hemotoxic enzymes continues to be a worldwide source of morbidity and mortality. The present work examined the effects of exposure of venom enzymes to carbon monoxide and O-phenylhydroxylamine, agents that modulate the biometal heme, by forming carboxyheme and metheme, respectively. Four venoms obtained from medically important, diverse snake venom found in Africa, Asia and Australia were analyzed. The species that had venom tested in human plasma with thrombelastography and heme modulating agents were Deinagkistrodon acutus, Protobothrops mucrosquamatus, Dispholidus typus and Pseudonaja textilis...
August 21, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30117045/iron-chelator-deferiprone-rescues-memory-deficits-hippocampal-bdnf-levels-and-antioxidant-defenses-in-an-experimental-model-of-memory-impairment
#4
Luisa Azambuja Alcalde, Betânia Souza de Freitas, Gustavo Dalto Barroso Machado, Pedro Castilhos de Freitas Crivelaro, Victoria Campos Dornelles, Henrique Gus, Ricardo Tavares Monteiro, Luiza Wilges Kist, Mauricio Reis Bogo, Nadja Schröder
Brain-derived neurotrophic factor (BDNF) plays a key role in neural development and physiology, as well as in pathological states. Post-mortem studies demonstrate that BDNF is reduced in the brains of patients affected by neurodegenerative diseases. Iron accumulation has also been associated to the pathogenesis of neurodegenerative diseases. In rats, iron overload induces persistent memory deficits, increases oxidative stress and apoptotic markers, and decreases the expression of the synaptic marker, synaptophysin...
August 16, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30008026/selenised-yeast-sources-differ-in-their-capacity-to-protect-porcine-jejunal-epithelial-cells-from-cadmium-induced-toxicity-and-oxidised-dna-damage
#5
Sarah Lynch, Karina Horgan, Dermot Walls, Blánaid White
In recent years there has been increasing interest in the use of selenised yeast (Se-Y) as an antioxidant feed supplement. Here, three selenised yeast products are differentiated in terms of bioefficiency and the ameliorative effect on Cadmium (Cd) toxicity in porcine epithelial cells. A porcine digestion in vitro model was chosen to more accurately simulate the bioavailability of different Se-Y preparations, allowing a comprehensive understanding of the bio efficiency of each Se-Y compound in the porcine model...
July 14, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30043289/iron-metabolism-in-diabetes-induced-alzheimer-s-disease-a-focus-on-insulin-resistance-in-the-brain
#6
REVIEW
Ji Yeon Chung, Hyung-Seok Kim, Juhyun Song
Alzheimer's disease (AD) is characterized by an excessive accumulation of toxic amyloid beta (Aβ) plaques and memory dysfunction. The onset of AD is influenced by age, genetic background, and impaired glucose metabolism in the brain. Several studies have demonstrated that diabetes involving insulin resistance and glucose tolerance could lead to AD, ultimately resulting in cognitive dysfunction. Even though the relationship between diabetes and AD was indicated by significant evidences, the critical mechanisms and metabolic alterations in diabetes induced AD are not clear until now...
October 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30030679/prevention-of-progression-in-parkinson-s-disease
#7
REVIEW
Jan Aaseth, Petr Dusek, Per M Roos
Environmental influences affecting genetically susceptible individuals seem to contribute significantly to the development of Parkinson's disease (PD). Xenobiotic exposure including transitional metal deposition into vulnerable CNS regions appears to interact with PD genes. Such exposure together with mitochondrial dysfunction evokes a destructive cascade of biochemical events, including oxidative stress and degeneration of the sensitive dopamine (DA) production system in the basal ganglia. Recent research indicates that the substantia nigra degeneration can be decelerated by treatment with iron binding compounds such as deferiprone...
October 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30027361/lanthanum-containing-bioparticles-are-associated-with-the-influence-of-lanthanum-on-high-phosphate-mediated-bone-marrow-stromal-cells-viability
#8
Jing Bai, Xiao-Hong Wang, Chan-Juan Zhang, Jian Huang, Werner E G Müller
Lanthanum (La)-based binder appears effective in reducing serum inorganic phosphate (Pi) levels among chronic dialysis patients, yet concern remains about La accumulation in bone during long-term oral administration. In this study, the effect of lanthanum chloride (LaCl3 ) on bone marrow stromal cells (BMSCs) viability was investigated under high Pi situation. We found low concentration (10-9  M) of LaCl3 increased BMSCs viability, while high concentration (10-5  M) of LaCl3 not only inhibited BMSCs viability but also stimulated high Pi induced cell apoptosis...
October 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30027360/expression-of-iron-regulators-in-the-bone-tissue-of-rats-with-and-without-iron-overload
#9
Yanqin Li, Bin Bai, Yaohui Zhang
Recently, more and more studies indicate that iron overload would cause osteopenia or osteoporosis. However, the molecular mechanism of it remains unclear. Moreover, very little is known about the iron metabolism in bone tissue at present. Therefore, the mRNA expression of iron-regulators, transferrin receptor1 (Tfr1), divalent metal transporter1 (Dmt1 + IRE and Dmt1 - IRE), ferritin (FtH and FtL), and ferroportin1 (Ireg1), and the localization of ferroportin1 protein were examined in the bone tissue of rats...
October 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30014355/oxidative-stress-and-neurodegeneration-the-involvement-of-iron
#10
REVIEW
Alessia Carocci, Alessia Catalano, Maria Stefania Sinicropi, Giuseppe Genchi
Many evidences indicate that oxidative stress plays a significant role in a variety of human disease states, including neurodegenerative diseases. Iron is an essential metal for almost all living organisms due to its involvement in a large number of iron-containing proteins and enzymes, though it could be also toxic. Actually, free iron excess generates oxidative stress, particularly in brain, where anti-oxidative defences are relatively low. Its accumulation in specific regions is associated with pathogenesis in a variety of neurodegenerative diseases (i...
October 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30014354/variation-on-a-theme-investigating-the-structural-repertoires-used-by-ferric-uptake-regulators-to-control-gene-expression
#11
REVIEW
Sabina Sarvan, James Butcher, Alain Stintzi, Jean-François Couture
In every living organism, the control of metal homoeostasis is a tightly regulated process coordinated by several intertwined biological pathways. In many bacteria, the ferric uptake regulator (Fur) family of transcriptional factors (TFs) are key factors in controlling the expression of genes involved in metal homeostasis and can also regulate the expression of genes involved in responses to oxidative stresses. Since the crystallization of Escherichia coli Fur DNA binding domain, the crystal structure of several metalloregulators have been reported...
October 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30014353/chromium-malate-alleviates-high-glucose-and-insulin-resistance-in-l6-skeletal-muscle-cells-by-regulating-glucose-uptake-and-insulin-sensitivity-signaling-pathways
#12
Weiwei Feng, Yangyang Ding, Weijie Zhang, Yao Chen, Qian Li, Wei Wang, Hui Chen, Yun Feng, Ting Zhao, Guanghua Mao, Liuqing Yang, Xiangyang Wu
Previous study revealed that chromium malate improved the regulation of fasting blood glucose and insulin resistance in type 2 diabetic rats. In this study, the effect of chromium malate on anti-high-glucose and improve insulin resistance activities in L6 skeletal muscle cells with insulin resistance and its acting mechanism were investigated. Chromium malate showed direct anti-high-glucose activity in vitro. The glucose levels had a significant downward trend compared to chromium trichloride. Compared with model group, chromium malate could significantly promote the secretion levels of GLUT-4, Akt, Irs-1, PPARγ, PI3K and p38-MAPK, promote AMPKβ1 phosphorylation, and reduced the level of p-Irs-1 in L6 cells with insulin resistance...
October 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30014352/high-selenium-yeast-mitigates-aluminum-induced-cerebral-inflammation-by-increasing-oxidative-stress-and-blocking-no-production
#13
Changyu Cao, Xiaowen Li, Lei Qin, Junchong Luo, Mengdan Zhang, Zijian Ou, Kai Wang
High Selenium Yeast (SeY) serves many important roles with respect to the maintenance of normal nervous system functioning. Studies have reported the nerve inflammation induced by Aluminum (Al) was associated with the increase of mortality. However, in-depth studies are required to verify the hypothesized neuro-protective efficacy of SeY against Al-induced cerebral damage through modulation of the inflammatory response. Here, mice were treated with SeY (0.1 mg/kg) and/or Al (10 mg/kg) by oral gavage for 28 days...
October 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30014351/ferrous-and-ferric-differentially-deteriorate-proliferation-and-differentiation-of-osteoblast-like-umr-106-cells
#14
Kornkamon Lertsuwan, Ketsaraporn Nammultriputtar, Supanan Nanthawuttiphan, Supathra Phoaubon, Jomnarong Lertsuwan, Jirawan Thongbunchoo, Kannikar Wongdee, Narattaphol Charoenphandhu
The association between iron overload and osteoporosis has been found in many diseases, such as hemochromatosis, β-thalassemia and sickle cell anemia with multiple blood transfusion. One of the contributing factors is iron toxicity to osteoblasts. Some studies showed the negative effects of iron on osteoblasts; however, the effects of two biological available iron species, i.e., ferric and ferrous, on osteoblasts are elusive. Since most intracellular ionized iron is ferric, osteoblasts was hypothesized to be more responsive to ferric iron...
October 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30006888/effects-of-lead-and-lead-melatonin-exposure-on-protein-and-gene-expression-of-metal-transporters-proteins-and-the-copper-zinc-ratio-in-rats
#15
Karla J Soto-Arredondo, Juvencio Robles, Erik Díaz-Cervantes, Carolina Ruiz-Ramírez, Marco A García-Revilla, Katarzyna Wrobel, Kazimierz Wrobel, Mauricio Díaz-Muñoz, Isabel Méndez, Alberto Flores, Francisco Javier Acevedo-Aguilar, Minerva Martínez-Alfaro
Human lead (Pb) exposure induces many adverse health effects, including some related to lead accumulation in organs. Although lead bio-distribution in the body has been described, the molecular mechanism underlying distribution and excretion is not well understood. The transport of essential and toxic metals is principally mediated by proteins. How lead affects the expression of metal transporter proteins in the principal metal excretory organs, i.e., the liver and kidney, is unknown. Considering that co-administration of melatonin and lead reduces the toxic effects of lead and lead levels in the blood in vivo, we examined how lead and co-administration of lead and melatonin affect the gene and protein expression of metal transporter proteins (ZIP8, ZIP14, CTR1 and DMT1) in these organs...
October 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29974287/zinc-preconditioning-protects-against-renal-ischaemia-reperfusion-injury-in-a-preclinical-sheep-large-animal-model
#16
Dermot O'Kane, Luke Gibson, Clive N May, Justin du Plessis, Arthur Shulkes, Graham S Baldwin, Damien Bolton, Joseph Ischia, Oneel Patel
Ischaemia-reperfusion injury (IRI) during various surgical procedures, including partial nephrectomy for kidney cancer or renal transplantation, is a major cause of acute kidney injury and chronic kidney disease. Currently there are no drugs or methods for protecting human organs, including the kidneys, against the peril of IRI. The aim of this study was therefore to investigate the reno-protective effect of Zn2+ preconditioning in a clinically relevant large animal sheep model of IRI. Further the reno-protective effectiveness of Zn2+ preconditioning was tested on normal human kidney cell lines HK-2 and HEK293...
October 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29959651/inorganic-mercury-in-human-astrocytes-oligodendrocytes-corticomotoneurons-and-the-locus-ceruleus-implications-for-multiple-sclerosis-neurodegenerative-disorders-and-gliomas
#17
Roger Pamphlett, Stephen Kum Jew
Neurotoxic metals have been implicated in the pathogenesis of multiple sclerosis, neurodegenerative disorders and brain tumours but studies of the location of heavy metals in human brains are rare. In a man who injected himself with metallic mercury the cellular location of mercury in his brain was studied after 5 months of continuous exposure to inorganic mercury arising from metallic mercury deposits in his organs. Paraffin sections from the primary motor and sensory cortices and the locus ceruleus in the pons were stained with autometallography to detect inorganic mercury and combined with glial fibrillary acidic protein immunohistochemistry to identify astrocytes...
October 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29956040/mass-spectrometric-characterization-of-siderophores-produced-by-pseudomonas-taiwanensis-vlb120-assisted-by-stable-isotope-labeling-of-nitrogen-source
#18
Karen Scholz, Till Tiso, Lars M Blank, Heiko Hayen
The structures of three previously unknown siderophores produced by the fluorescent, biotechnologically relevant Pseudomonas taiwanensis (P. taiwanensis) VLB120 bacteria were elucidated by means of hydrophilic interaction liquid chromatography (HILIC) hyphenated to high-resolution tandem mass spectrometry (HRMS/MS). They could be verified as iron(III)- and aluminum(III) complexes as well as the protonated molecules of the siderophores formed by in-source fragmentation. The siderophores were separated according to their different acyl side chains and additionally according their central ions...
October 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29951879/iron-chelation-inhibits-cancer-cell-growth-and-modulates-global-histone-methylation-status-in-colorectal-cancer
#19
Lin-Lin Cao, Hangqi Liu, Zhihong Yue, Lianhua Liu, Lin Pei, Junxu Gu, Hui Wang, Mei Jia
Colorectal cancer (CRC) is one of the most common malignancies worldwide, and new treatment strategies for CRC are required because of the existing chemotherapy resistance. Iron chelators, which have been used widely for the treatment of iron-overload disease, were reported to exert anti-proliferative effects in cancer. However, the role of iron chelation in CRC was largely unknown. In this study, we found that the iron chelator DFO inhibited CRC cell growth significantly. In addition, the gene expression profile was greatly changed by DFO treatment, and many cell growth-related genes were dysregulated...
October 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29946993/antimicrobial-properties-of-ternary-eutectic-aluminum-alloys
#20
Claudia Hahn, Michael Hans, Christina Hein, Anne Dennstedt, Frank Mücklich, Petra Rettberg, Christine Elisabeth Hellweg, Lars Ingo Leichert, Christopher Rensing, Ralf Moeller
Several Escherichia coli deletion mutants of the Keio collection were selected for analysis to better understand which genes may play a key role in copper or silver homeostasis. Each of the selected E. coli mutants had a deletion of a single gene predicted to encode proteins for homologous recombination or contained functions directly linked to copper or silver transport or transformation. The survival of these strains on pure copper surfaces, stainless steel, and alloys of aluminum, copper and/or silver was investigated...
October 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
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