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Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine

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https://www.readbyqxmd.com/read/30387073/role-of-nitric-oxide-and-hydrogen-sulfide-in-plant-aluminum-tolerance
#1
REVIEW
Huyi He, Yingqiu Li, Long-Fei He
As gasotransmitter, nitric oxide (NO) and hydrogen sulfide (H2 S) are involved in the regulation of plant tolerance to abiotic stresses. Aluminum (Al) toxicity triggers synthesis of NO and H2 S and seriously affects plant growth and productivity. Exogenous NO and H2 S alleviate Al toxicity in plants. However, the physiological and molecular mechanisms of NO and H2 S in alleviating Al toxicity are very scattered. In this review, the advances in the effects of Al on the content of endogenous NO and H2 S and the mechanisms of exogenous NO and H2 S in alleviating Al toxicity in plants are summarized and discussed...
November 1, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30367340/new-platinum-ii-and-palladium-ii-complexes-with-substituted-terpyridine-ligands-synthesis-and-characterization-cytotoxicity-and-reactivity-towards-biomolecules
#2
Aleksandar Savić, Tiziano Marzo, Federica Scaletti, Lara Massai, Gianluca Bartoli, Richard Hoogenboom, Luigi Messori, Rik Van Deun, Kristof Van Hecke
A series of palladium(II) (1-3) and platinum(II) chloride complexes (4 and 5) with 2,2':6',2″-terpyridine (terpy) derivatives substituted at the 4' position, was synthesized and fully characterized. Single crystal X-ray diffraction analysis of complexes 2, 3 and 5 showed tridentate coordination of the 4'-substituted terpyridine (terpy) ligands to the metal center. Moreover, in vitro cytotoxic activity of these complexes toward a panel of human cancer cell lines (lung cancer A549, colorectal cancer HCT116, ovarian cancer IGROV-1) and toward normal cell line HDF (dermal fibroblast) was determined by Trypan Blue exclusion assay...
October 26, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30334122/copper-complex-with-sulfamethazine-and-2-2-bipyridine-supported-on-mesoporous-silica-microspheres-improves-its-antitumor-action-toward-human-osteosarcoma-cells-cyto-and-genotoxic-effects
#3
Juan Fernando Cadavid-Vargas, Pablo Maximiliano Arnal, Ruth Dary Mojica Sepúlveda, Andrea Rizzo, Delia Beatriz Soria, Ana Laura Di Virgilio
Ideal drugs to cure cancer leave normal cells unharmed while selectively turning tumor cells unviable. Several copper complexes have been able to selectively slow down tumor proliferation. We hypothesized that Cu(smz)2 (bipy)·H2 O (1)-a copper-complex that has two ligands capable of interacting with DNA-would outperform Cu(smz)2 (OH2 )·2H2 O (2), and also that supporting 1 on mesoporous silica spheres would decrease even further tumor cell viability in vitro. After exposing osteosarcoma cells (MG-63) and normal phenotype cells of bone origin (MC3T3-E1) to either complex, we studied their toxic effect and mechanisms of action...
October 17, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30327978/nickel-and-cobalt-affect-galactosylation-of-recombinant-igg-expressed-in-cho-cells
#4
Anuja Prabhu, Mugdha Gadgil
Glycosylation is an important product quality attribute of antibody biopharmaceuticals. It involves enzymatic addition of oligosaccharides on proteins by sequential action of glycosyltransferases and glycosidases in the endoplasmic reticulum and golgi. Some of these enzymes like galactosyltransferase and N-acetylglucosaminyltransferase-I require trace metal cofactors. Variations in trace metal availability during production can thus affect glycosylation of recombinant glycoproteins such as monoclonal antibodies...
October 16, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30324285/physicochemical-characterization-of-ferric-pyrophosphate-citrate
#5
Ajay Gupta, Raymond Pratt, Bhoopesh Mishra
Iron deficiency is a significant health problem across the world. While many patients benefit from oral iron supplements, some, including those on hemodialysis require intravenous iron therapy to maintain adequate iron levels. Until recently, all iron compounds suitable for parenteral administration were colloidal iron-carbohydrate conjugates that require uptake and processing by macrophages. These compounds are associated with variable risk of anaphylaxis, oxidative stress, and inflammation, depending on their physicochemical characteristics...
October 15, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30317404/protective-effect-of-tea-against-lead-and-cadmium-induced-oxidative-stress-a-review
#6
REVIEW
Anna Winiarska-Mieczan
Exposure to Cd and Pb reduces the activity of antioxidant enzymes, which points to a decrease in the antioxidant potential of the body as a result of supplying factors which enhance cellular oxidation processes. Man is exposed to the effects of toxic metals because they are present in the environment, including in food. Since no effective ways to reduce the concentrations of Cd an Pb in food exist, studies are undertaken to develop methods of reducing their toxic effect on the body through chelating these metals using nutrients (which reduces their absorption by tissues) or increasing the oxidative capacity of the body (which decreases the possibility of inducing oxidative damage to internal organs)...
October 13, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30311020/studies-on-the-activation-of-isocitrate-dehydrogenase-kinase-phosphatase-acek-by-mn-2-and-mg-2
#7
Yanxia Yin, Yadan Gao, Shanze Li, Guohua Jiang, Qun Wei
Isocitrate dehydrogenase kinase/phosphatase (AceK) is a bifunctional enzyme with both kinase and phosphatase activities that are activated by Mg2+ . We have studied the interactions of Mn2+ and Mg2+ with AceK using isothermal titration calorimetry (ITC) combined with molecular docking simulations and show for the first time that Mn2+ also activates the enzyme activities. However, Mn2+ and Mg2+ exert their effects by different mechanisms. Although they have similar binding constants (of 1.11 × 105 and 0...
October 12, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30311019/ferric-pyrophosphate-citrate-interactions-with-transferrin
#8
Raymond Pratt, Garry J Handelman, Thomas E Edwards, Ajay Gupta
There are several options available for intravenous application of iron supplements, but they all have a similar structure:-an iron core surrounded by a carbohydrate coating. These nanoparticles require processing by the reticuloendothelial system to release iron, which is subsequently picked up by the iron-binding protein transferrin and distributed throughout the body, with most of the iron supplied to the bone marrow. This process risks exposing cells and tissues to free iron, which is potentially toxic due to its high redox activity...
October 11, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30306383/aging-results-in-iron-accumulations-in-the-non-human-primate-choroid-of-the-eye-without-an-associated-increase-in-zinc-copper-or-sulphur
#9
M Ugarte, K Geraki, G Jeffery
We present further analyses of a previous experiment published in 2016 where the distribution, concentration and correlation of iron, zinc, copper and sulphur in the choroid of the eye in young and aged old world primates (Macaca fascicularis) was studied with synchrotron X-ray fluorescence with a 2 μm resolution. The results indicate that iron accumulates in hotspots in the choroid with age with fluorescence intensity ranging from 2- to 7-fold (1002-3752 ppm) the mean level in the choroidal stroma (500 ppm) and maximum iron levels in blood vessel lumina...
October 10, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30298455/the-effects-of-the-timing-of-exposure-to-cadmium-on-the-oviposition-behavior-of-drosophila-melanogaster
#10
Andrea Bixler, Fred B Schnee
Animals can greatly increase their fitness by choosing oviposition sites free from damaging substances such as the heavy metal cadmium (Cd). Previous research has shown that Drosophila melanogaster reared on uncontaminated media lay fewer eggs on substrates containing Cd. In this study, we examined the effects of prior exposure to Cd on oviposition site preference. We tested flies that had been exposed to Cd continuously from egg to adult, only during pre-adult stages, or for the 4 days of adulthood prior to testing...
October 8, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30291581/citrate-analysis-using-capillary-electrophoresis-and-complexation-with-eu-3-tetracycline
#11
Douglas B Craig, Jennifer R Lischynski, Isabela C C Cardoso
A sensitive assay for citrate was developed. Citrate was incubated with 50 μM Eu3+ -tetracycline and the complex separated using capillary electrophoresis utilizing post-column laser-induced luminescence detection in a sheath flow cuvette. Signal was linear with citrate concentration from 10 μM to 200 nM. Injection volumes were 320 pL. For the 200 nM sample, this corresponds to the injection of 64 amoles of citrate. Separation time was < 90 s with a total run time of 5 min. As an application the method was used to analyze citrate in agricultural and medicinal products...
October 5, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30288658/selenium-rich-yeast-protects-against-aluminum-induced-peroxidation-of-lipide-and-inflammation-in-mice-liver
#12
Junchong Luo, Xiaowen Li, Xinran Li, Yongming He, Mengdan Zhang, Changyu Cao, Kai Wang
To investigate the effect of Selenium Rich Yeast (SeY) on hepatotoxicity of Aluminium (Al), SeY (0.1 mg/kg) was orally administrated to aluminium-exposed mice (10 mg/kg) for 28 days. The risk of oxidative stress was assessed by detecting the total antioxidant capacity (T-AOC), catalase activity, H2 O2 content, and mRNA levels of the Keap1/Nrf-2/HO-1 pathway. Inflammatory reactions were assessed by detecting the mRNA levels of inflammatory biomarkers. Our results showed that SeY protected against the liver histological changes induce by Al...
October 4, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30288657/genome-wide-exploration-of-c2h2-zinc-finger-family-in-durum-wheat-triticum-turgidum-ssp-durum-insights-into-the-roles-in-biological-processes-especially-stress-response
#13
Sahar Faraji, Seyyed Hamidreza Rasouli, Seyyed Kamal Kazemitabar
C2H2 type of zinc finger transcription factors (C2H2-ZFP TFs) play crucial roles in plant developments and stress response. Regarding its importance, genome-wide study of C2H2-ZFs were performed in multiple important plant species, but any such investigation was not fulfilled in Triticum turgidum ssp. Durum (durum wheat) as an important nutritional crop. The present study identified 122 C2H2-ZFs in durum wheat and physically mapped them onto the genome. The phylogenetic analysis classified these TFs into six major groups...
October 4, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30284644/chromosomal-sil-system-contributes-to-silver-resistance-in-e-coli-atcc-8739
#14
Mariana Blanco Massani, Jochen Klumpp, Madeleine Widmer, Christian Speck, Marc Nisple, Rainer Lehmann, Markus Schuppler
The rise of antibiotic resistance in pathogenic bacteria is endangering the efficacy of antibiotics, which consequently results in greater use of silver as a biocide. Chromosomal mapping of the Cus system or plasmid encoded Sil system and their relationship with silver resistance was studied for several gram-negative bacteria. However, only few reports investigated silver detoxification mediated by the Sil system integrated in Escherichia coli chromosome. Accordingly, this work aimed to study the Sil system in E...
October 4, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30284643/in-vitro-leishmanicidal-activity-and-theoretical-insights-into-biological-action-of-ruthenium-ii-organometallic-complexes-containing-anti-inflammatories
#15
Victor M Miranda, Monica S Costa, Silvana Guilardi, Antonio E H Machado, Javier A Ellena, Kelly A G Tudini, Gustavo Von Poelhsitz
Leishmaniasis, a neglected tropical disease caused by protozoans of the genus Leishmania, kills around 20-30 thousand people in Africa, Asia, and Latin America annually and, despite its potential lethality, it can be treated and eventually cured. However, the current treatments are limited owing to severe side effects and resistance development by some Leishmania. These factors make it urgent to develop new leishmanicidal drugs. In the present study, three ruthenium(II) organometallic complexes containing as ligands the commercially available anti-inflammatories diclofenac (dic), ibuprofen (ibu), and naproxen (nap) were synthesized, characterized, and subjected to in vitro leishmanicidal activity...
October 4, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30284152/silver-in-the-meat-and-organs-of-broiler-chickens-in-case-of-using-colloidal-silver-as-an-alternative-to-antibiotics
#16
Aleksandrova Svetlana Sergeevna, Simonov Oleg Anatolevich, Shigabaeva Gulnara Nurchallaeva, Bakharev Alexey Aleksandrovich, Renev Evgeniy Petrovich, Shabaldin Sergey Vladimirovich, Grigoreva Marina Alexeevna, Ivanov Igor Diadorovitch
The search for new antibacterial products, the mechanisms of action of which differ from conventional antibiotics is a current a topical issue. The objective of our research is to identify the presence of silver in meat and organs of broiler chicks that had been given colloidal silver. The results show that the broiler chick meat contains silver in quantities safe for humans regardless of the use of colloidal silver. Comparison of meat analysis results in experimental and control groups indicate that the ratio of parameters distribution variance for all birds to the mean variance by group for each measured no statistical differences in the chemical composition of bird's meat of experimental and control groups...
October 3, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30259247/effect-of-a-new-anti-t-cruzi-metallic-compound-based-on-palladium
#17
M Florencia Mosquillo, Lucía Bilbao, Fabricio Hernández, Ignacio Machado, Dinorah Gambino, Beatriz Garat, Leticia Pérez-Díaz
Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. It is estimated that 6 million people are infected in Latin America. Current treatment is not effective due to the severe side effects and the limited efficacy towards the chronic phase of the disease. Considering the growing need for specific anti-Trypanosoma cruzi drugs, organometallic Pt and Pd based compounds were previously synthesized. Although the Pt-based compound effects on T. cruzi death have been reported, no mechanism of action has been proposed for the Pd-based analogous compound...
September 26, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30255365/vanadium-complex-an-appropriate-candidate-for-killing-hepatocellular-carcinoma-cancerous-cells
#18
Hamid Bakhshi Aliabad, Soudeh Khanamani Falahati-Pour, Hadis Ahmadirad, Maryam Mohamadi, Mohammad Reza Hajizadeh, Mehdi Mahmoodi
Hepatocellular carcinoma (HCC) is a prevalent human malignancy which its drug resistance is increasing world-wide. This project was designed to assess the anti-cancer effects of 4-bromo-2-(((5-chloro-2-hydroxyphenyl) imino) methyl) phenol ([IV(L)] complex) on the HepG2 cell line and also L929 cells, as normal cells. HepG2 and L929 cells were cultured in RPMI culture medium and the survival rates of the cells were determined after 24 and 48 h using MTT assay to find IC50 concentration of vanadium m, [IV(L)] complex...
September 25, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30225625/correction-to-iron-metabolism-in-diabetes-induced-alzheimer-s-disease-a-focus-on-insulin-resistance-in-the-brain
#19
Ji Yeon Chung, Hyung-Seok Kim, Juhyun Song
Due to a technical error, the copyright line of the above mentioned article was incorrect. The original publication has been corrected.
September 17, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30136243/lfchimera-protects-hela-cells-from-invasion-by-yersinia-spp-in-vitro
#20
Tjitske Sijbrandij, Antoon J Ligtenberg, Kamran Nazmi, Petra A M van den Keijbus, Enno C I Veerman, Jan G M Bolscher, Floris J Bikker
Yersinia pestis is the causative agent of plague. As adequate antibiotic treatment falls short and currently no effective vaccine is available, alternative therapeutic strategies are needed. In order to contribute to solving this problem we investigated the therapeutic potential of the peptide construct LFchimera against the safer-to-handle Y. pestis simulants Yersinia enterocolitica and Yersinia pseudotuberculosis in vitro. LFchimera is a heterodimeric peptide construct mimicking two antimicrobial domains of bovine lactoferrin, i...
August 22, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
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