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Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine

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https://www.readbyqxmd.com/read/30637584/determination-of-iron-species-including-biomineralized-jarosite-in-the-iron-hyperaccumulator-moss-scopelophila-ligulata-by-m%C3%A3-ssbauer-x-ray-diffraction-and-elemental-analyses
#1
Hiromitsu Nakajima, Atsushi Okazawa, Shiro Kubuki, Qing Shen, Kiminori Itoh
Scopelophila ligulata is an Fe-hyperaccumulator moss growing in acidic environments, but the mechanism of Fe accumulation remains unknown. To understand the mechanism, we determined Fe species in S. ligulata samples. The moss samples were collected from four sites in Japan. The concentrations of Fe, P, S, Cl, and K in them were measured by induced coupled plasma mass spectrometry. Fe species in some of them were determined by Mössbauer spectroscopy and were confirmed by X-ray diffraction analysis. Fe species in S...
January 12, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30635814/complexes-formed-by-the-siderophore-based-monosulfactam-antibiotic-bal30072-and-their-interaction-with-the-outer-membrane-receptor-piua-of-p-aeruginosa
#2
Mariano Andrea Scorciapino, Giuliano Malloci, Ilaria Serra, Stefan Milenkovic, Lucile Moynié, James H Naismith, Eric Desarbre, Malcolm G P Page, Matteo Ceccarelli
Nuclear magnetic resonance and infrared spectroscopy have been used to investigate the formation of complexes of BAL30072 with Fe3+ and Ga3+ in solution and to collect geometrical parameters supporting reliable 3D structure models. Structural models for the ligand-metal complexes with different stoichiometries have been characterized using density functional theory calculations. Blind ensemble docking to the PiuA receptor from P. aeruginosa was performed for the different complexes to compare binding affinities and statistics of the residues most frequently contacted...
January 11, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30623317/distribution-of-dissolved-iron-and-bacteria-producing-the-photoactive-siderophore-vibrioferrin-in-waters-off-southern-california-and-northern-baja
#3
Kyoko Yarimizu, Ricardo Cruz-López, Ernesto García-Mendoza, Matthew Edwards, Melissa L Carter, Carl J Carrano
Phytoplankton blooms can cause acute effects on marine ecosystems due either to their production of endogenous toxins or to their enormous biomass leading to major impacts on local economies and public health. Despite years of effort, the causes of these Harmful Algal Blooms are still not fully understood. Our hypothesis is that bacteria that produce photoactive siderophores may provide a bioavailable source of iron for phytoplankton which could in turn stimulate algal growth and support bloom dynamics. Here we correlate iron concentrations, phytoplankton cell counts, bacterial cell abundance, and copy numbers for a photoactive siderophore vibrioferrin biosynthesis gene in water samples taken from 2017 cruises in the Gulf of California, and the Pacific Ocean off the coast of northern Baja California as well as during a multiyear sampling at Scripps Pier in San Diego, CA...
January 8, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30564968/mirna-target-interactions-in-osteogenic-signaling-pathways-involving-zinc-via-the-metal-regulatory-element
#4
Michael Francis, Arthur Grider
Adequate zinc nutriture is necessary for normal bone growth and development, though the precise mechanisms for zinc-mediated bone growth remain poorly defined. A key transcription factor activated by zinc is metal response element-binding transcription factor 1 (MTF-1), which binds to the metal regulatory element (MRE). We hypothesize that MREs will be found upstream of miRNA genes as well as miRNA target genes in the following bone growth and development signaling pathways: TGF-β, MAPK, and Wnt. A Bioconductor-based workflow in R was designed to identify interactions between MREs, miRNAs, and target genes...
December 18, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30560539/cadmium-induced-glutathione-bioaccumulation-mediated-by-%C3%AE-glutamylcysteine-synthetase-in-ectomycorrhizal-fungus-hebeloma-cylindrosporum
#5
Shikha Khullar, M Sudhakara Reddy
Ectomycorrhizal fungi hold a potential role in bioremediation of heavy metal polluted areas because of its metal accumulation and detoxification property. We investigated the cadmium (Cd) induced bioaccumulation of glutathione (GSH) mediated by γ-glutamylcysteine synthetase (γ-GCS) in the ectomycorrhizal fungus Hebeloma cylindrosporum. In H. cylindrosporum, a demand driven synthesis of GSH has been observed in response to Cd. The expression and enzyme activity of H. cylindrosporum γ-GCS (Hcγ-GCS) increased as a function of external Cd stress resulting in increased GSH production...
December 17, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30506342/determination-of-in-vitro-absorption-in-caco-2-monolayers-of-anticancer-ru-ii-based-complexes-acting-as-dual-human-topoisomerase-and-parp-inhibitors
#6
Mariana S de Camargo, Rone A De Grandis, Monize M da Silva, Patricia B da Silva, Mariana M Santoni, Carlos E Eismann, Amauri A Menegário, Marcia R Cominetti, Cleslei F Zanelli, Fernando R Pavan, Alzir A Batista
Due to their unique and versatile biochemical properties, ruthenium-based compounds have emerged as promising anticancer agents. Previous studies showed that three ruthenium(II) compounds: [Ru(pySH)(bipy)(dppb)]PF6 (1), [Ru(HSpym)(bipy)(dppb)]PF6 (2) and Ru[(SpymMe2 )(bipy)(dppb)]PF6 (3) presented anticancer properties higher than doxorubicin and cisplatin and acted as human topoisomerase IB (Topo I) inhibitors. Here, we focused our studies on in vitro intestinal permeability and anticancer mechanisms of these three complexes...
November 30, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30474772/algae-induce-siderophore-biosynthesis-in-the-freshwater-bacterium-cupriavidus-necator-h16
#7
Colette Kurth, Ina Wasmuth, Thomas Wichard, Georg Pohnert, Markus Nett
Cupriachelin is a photoreactive lipopeptide siderophore produced by the freshwater bacterium Cupriavidus necator H16. In the presence of sunlight, the iron-loaded siderophore undergoes photolytic cleavage, thereby releasing solubilized iron into the environment. This iron is not only available to the siderophore producer, but also to the surrounding microbial community. In this study, the cupriachelin-based interaction between C. necator H16 and the freshwater diatom Navicula pelliculosa was investigated. A reporter strain of the bacterium was constructed to study differential expression levels of the cupriachelin biosynthesis gene cucJ in response to varying environmental conditions...
November 24, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30471007/arsenite-biotransformation-and-bioaccumulation-by-klebsiella-pneumoniae-strain-sssw7-possessing-arsenite-oxidase-aioa-gene
#8
Sajiya Yusuf Mujawar, Kashif Shamim, Diviya Chandrakant Vaigankar, Santosh Kumar Dubey
Arsenite oxidizing Klebsiella pneumoniae strain SSSW7 isolated from shipyard waste Goa, India showed a minimum inhibitory concentration of 21 mM in mineral salts medium. The strain possessed a small supercoiled plasmid and PCR amplification of arsenite oxidase gene (aioA) was observed on plasmid as well as chromosomal DNA. It was confirmed that arsenite oxidase enzyme was a periplasmic protein with a 47% increase in arsenite oxidase activity at 1 mM sodium arsenite. Scanning electron microscopy coupled with electron dispersive X-ray spectroscopic (SEM-EDS) analysis of 15 mM arsenite exposed cells revealed long chains of cells with no surface adsorption of arsenic...
November 23, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30430296/altered-drug-efflux-under-iron-deprivation-unveils-abrogated-mmpl3-driven-mycolic-acid-transport-and-fluidity-in-mycobacteria
#9
Rahul Pal, Saif Hameed, Zeeshan Fatima
Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) is a global threat to human health hence better understanding of the MTB pathogenesis for improved therapeutics requires immediate attention. Emergence of drug-resistant strains has stimulated an urgent need for adopting new strategies that could be implemented to control TB. One of the contributing mechanisms by which MTB evades drug doses is overexpression of drug efflux pumps. Thus blocking or modulating the functionality of efflux pumps represents an attractive approach to combat drug resistance...
November 15, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30387073/role-of-nitric-oxide-and-hydrogen-sulfide-in-plant-aluminum-tolerance
#10
REVIEW
Huyi He, Yingqiu Li, Long-Fei He
As gasotransmitter, nitric oxide (NO) and hydrogen sulfide (H2 S) are involved in the regulation of plant tolerance to abiotic stresses. Aluminum (Al) toxicity triggers synthesis of NO and H2 S and seriously affects plant growth and productivity. Exogenous NO and H2 S alleviate Al toxicity in plants. However, the physiological and molecular mechanisms of NO and H2 S in alleviating Al toxicity are very scattered. In this review, the advances in the effects of Al on the content of endogenous NO and H2 S and the mechanisms of exogenous NO and H2 S in alleviating Al toxicity in plants are summarized and discussed...
November 1, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30367340/new-platinum-ii-and-palladium-ii-complexes-with-substituted-terpyridine-ligands-synthesis-and-characterization-cytotoxicity-and-reactivity-towards-biomolecules
#11
Aleksandar Savić, Tiziano Marzo, Federica Scaletti, Lara Massai, Gianluca Bartoli, Richard Hoogenboom, Luigi Messori, Rik Van Deun, Kristof Van Hecke
A series of palladium(II) (1-3) and platinum(II) chloride complexes (4 and 5) with 2,2':6',2″-terpyridine (terpy) derivatives substituted at the 4' position, was synthesized and fully characterized. Single crystal X-ray diffraction analysis of complexes 2, 3 and 5 showed tridentate coordination of the 4'-substituted terpyridine (terpy) ligands to the metal center. Moreover, in vitro cytotoxic activity of these complexes toward a panel of human cancer cell lines (lung cancer A549, colorectal cancer HCT116, ovarian cancer IGROV-1) and toward normal cell line HDF (dermal fibroblast) was determined by Trypan Blue exclusion assay...
October 26, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30334122/copper-complex-with-sulfamethazine-and-2-2-bipyridine-supported-on-mesoporous-silica-microspheres-improves-its-antitumor-action-toward-human-osteosarcoma-cells-cyto-and-genotoxic-effects
#12
Juan Fernando Cadavid-Vargas, Pablo Maximiliano Arnal, Ruth Dary Mojica Sepúlveda, Andrea Rizzo, Delia Beatriz Soria, Ana Laura Di Virgilio
Ideal drugs to cure cancer leave normal cells unharmed while selectively turning tumor cells unviable. Several copper complexes have been able to selectively slow down tumor proliferation. We hypothesized that Cu(smz)2 (bipy)·H2 O (1)-a copper-complex that has two ligands capable of interacting with DNA-would outperform Cu(smz)2 (OH2 )·2H2 O (2), and also that supporting 1 on mesoporous silica spheres would decrease even further tumor cell viability in vitro. After exposing osteosarcoma cells (MG-63) and normal phenotype cells of bone origin (MC3T3-E1) to either complex, we studied their toxic effect and mechanisms of action...
October 17, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30327978/nickel-and-cobalt-affect-galactosylation-of-recombinant-igg-expressed-in-cho-cells
#13
Anuja Prabhu, Mugdha Gadgil
Glycosylation is an important product quality attribute of antibody biopharmaceuticals. It involves enzymatic addition of oligosaccharides on proteins by sequential action of glycosyltransferases and glycosidases in the endoplasmic reticulum and golgi. Some of these enzymes like galactosyltransferase and N-acetylglucosaminyltransferase-I require trace metal cofactors. Variations in trace metal availability during production can thus affect glycosylation of recombinant glycoproteins such as monoclonal antibodies...
October 16, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30324285/physicochemical-characterization-of-ferric-pyrophosphate-citrate
#14
Ajay Gupta, Raymond Pratt, Bhoopesh Mishra
Iron deficiency is a significant health problem across the world. While many patients benefit from oral iron supplements, some, including those on hemodialysis require intravenous iron therapy to maintain adequate iron levels. Until recently, all iron compounds suitable for parenteral administration were colloidal iron-carbohydrate conjugates that require uptake and processing by macrophages. These compounds are associated with variable risk of anaphylaxis, oxidative stress, and inflammation, depending on their physicochemical characteristics...
October 15, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30317404/protective-effect-of-tea-against-lead-and-cadmium-induced-oxidative-stress-a-review
#15
REVIEW
Anna Winiarska-Mieczan
Exposure to Cd and Pb reduces the activity of antioxidant enzymes, which points to a decrease in the antioxidant potential of the body as a result of supplying factors which enhance cellular oxidation processes. Man is exposed to the effects of toxic metals because they are present in the environment, including in food. Since no effective ways to reduce the concentrations of Cd an Pb in food exist, studies are undertaken to develop methods of reducing their toxic effect on the body through chelating these metals using nutrients (which reduces their absorption by tissues) or increasing the oxidative capacity of the body (which decreases the possibility of inducing oxidative damage to internal organs)...
October 13, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30311020/studies-on-the-activation-of-isocitrate-dehydrogenase-kinase-phosphatase-acek-by-mn-2-and-mg-2
#16
Yanxia Yin, Yadan Gao, Shanze Li, Guohua Jiang, Qun Wei
Isocitrate dehydrogenase kinase/phosphatase (AceK) is a bifunctional enzyme with both kinase and phosphatase activities that are activated by Mg2+ . We have studied the interactions of Mn2+ and Mg2+ with AceK using isothermal titration calorimetry (ITC) combined with molecular docking simulations and show for the first time that Mn2+ also activates the enzyme activities. However, Mn2+ and Mg2+ exert their effects by different mechanisms. Although they have similar binding constants (of 1.11 × 105 and 0...
October 12, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30311019/ferric-pyrophosphate-citrate-interactions-with-transferrin
#17
Raymond Pratt, Garry J Handelman, Thomas E Edwards, Ajay Gupta
There are several options available for intravenous application of iron supplements, but they all have a similar structure:-an iron core surrounded by a carbohydrate coating. These nanoparticles require processing by the reticuloendothelial system to release iron, which is subsequently picked up by the iron-binding protein transferrin and distributed throughout the body, with most of the iron supplied to the bone marrow. This process risks exposing cells and tissues to free iron, which is potentially toxic due to its high redox activity...
October 11, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30306383/aging-results-in-iron-accumulations-in-the-non-human-primate-choroid-of-the-eye-without-an-associated-increase-in-zinc-copper-or-sulphur
#18
M Ugarte, K Geraki, G Jeffery
We present further analyses of a previous experiment published in 2016 where the distribution, concentration and correlation of iron, zinc, copper and sulphur in the choroid of the eye in young and aged old world primates (Macaca fascicularis) was studied with synchrotron X-ray fluorescence with a 2 μm resolution. The results indicate that iron accumulates in hotspots in the choroid with age with fluorescence intensity ranging from 2- to 7-fold (1002-3752 ppm) the mean level in the choroidal stroma (500 ppm) and maximum iron levels in blood vessel lumina...
October 10, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30298455/the-effects-of-the-timing-of-exposure-to-cadmium-on-the-oviposition-behavior-of-drosophila-melanogaster
#19
Andrea Bixler, Fred B Schnee
Animals can greatly increase their fitness by choosing oviposition sites free from damaging substances such as the heavy metal cadmium (Cd). Previous research has shown that Drosophila melanogaster reared on uncontaminated media lay fewer eggs on substrates containing Cd. In this study, we examined the effects of prior exposure to Cd on oviposition site preference. We tested flies that had been exposed to Cd continuously from egg to adult, only during pre-adult stages, or for the 4 days of adulthood prior to testing...
October 8, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30291581/citrate-analysis-using-capillary-electrophoresis-and-complexation-with-eu-3-tetracycline
#20
Douglas B Craig, Jennifer R Lischynski, Isabela C C Cardoso
A sensitive assay for citrate was developed. Citrate was incubated with 50 μM Eu3+ -tetracycline and the complex separated using capillary electrophoresis utilizing post-column laser-induced luminescence detection in a sheath flow cuvette. Signal was linear with citrate concentration from 10 μM to 200 nM. Injection volumes were 320 pL. For the 200 nM sample, this corresponds to the injection of 64 amoles of citrate. Separation time was < 90 s with a total run time of 5 min. As an application the method was used to analyze citrate in agricultural and medicinal products...
October 5, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
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