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Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine

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https://www.readbyqxmd.com/read/29143154/deciphering-the-molecular-events-during-arsenic-induced-transcription-signal-cascade-activation-in-cellular-milieu
#1
REVIEW
Harishkumar Madhyastha, Radha Madhyastha, Yuichi Nakajima, Masugi Maruyama
Anthropogenic sources of arsenic poses and creates unintentional toxico-pathological concerns to humans in many parts of the world. The understanding of toxicity of this metalloid, which shares properties of both metal and non-metal is principally structured on speciation types and holy grail of toxicity prevention. Visible symptoms of arsenic toxicity include nausea, vomiting, diarrhea and abdominal pain. In this review, we focused on the dermal cell stress caused by trivalent arsenic trioxide and pentavalent arsanilic acid...
November 15, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29110163/selenite-removal-and-reduction-by-growing-aspergillus-sp-j2
#2
Zhijian Li, Haifeng Li, Huiying Hu
In this study, the removal and reduction of selenite [Se(IV)] by growing Aspergillus sp. J2 were investigated. The lag phase, growth rate and biomass of J2 was not significantly influenced by the presence of 100 mg/L Se(IV). A rapid Se(IV) removal process took place from the 3rd to the 4th day during the growth of J2. Scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy and X-ray diffraction analyses showed that the Se(IV) did not cause any visible effects on cell morphology and the reduced amorphous elemental selenium [Se(0)] nanoparticles were mainly on the surface of the mycelial cell walls...
November 6, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29098502/cadmium-pyrithione-suppresses-tumor-growth-in-vitro-and-in-vivo-through-inhibition-of-proteasomal-deubiquitinase
#3
Xin Chen, Jinjie Wu, Qianqian Yang, Xiaolan Zhang, Peiquan Zhang, Siyan Liao, Zhimin He, Xuejun Wang, Chong Zhao, Jinbao Liu
The ubiquitin-proteasome system (UPS) is indispensable to the protein quality control in eukaryotic cells. Due to the remarkable clinical success of using proteasome inhibitors for clinical treatment of multiple myeloma, it is anticipated that targeting the UPS upstream of the proteasome step be an effective strategy for cancer therapy. Deubiquitinases (DUB) are proteases that remove ubiquitin from target proteins and therefore regulate multiple cellular processes including some signaling pathways altered in cancer cells...
November 3, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29081021/life-and-death-of-trypanosoma-cruzi-in-presence-of-metals
#4
Laís Pessanha de Carvalho, Edésio José Tenório de Melo
Trypanosoma cruzi has many molecules that need metallic elements to work, allowing cell invasion and the establishment of infection, causing Chagas disease. Nonetheless, knowledge regarding how the parasites address metals and maintain homeostasis is lacking. To study this relationship, zinc, cadmium and mercury were chosen. Epimastigote, trypomastigote and intracellular forms of T. cruzi were incubated with these metals for different times and at different concentrations. In general, epimastigotes were the most sensitive and trypomastigotes the most resistant to metals...
October 28, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29067573/iron-uptake-and-storage-in-the-hab-dinoflagellate-lingulodinium-polyedrum
#5
Kyoko Yarimizu, Ricardo Cruz-López, Hendrik Auerbach, Larissa Heimann, Volker Schünemann, Carl J Carrano
The iron uptake and storage systems of terrestrial/higher plants are now reasonably well understood with two basic strategies being distinguished: Strategy I involves the induction of an Fe(III)-chelate reductase (ferrireductase) along with Fe(II) or Fe(III) transporter proteins while strategy II plants have evolved sophisticated systems based on high-affinity, iron specific, binding compounds called phytosiderophores. In contrast, there is little knowledge about the corresponding systems in marine, plant-like lineages...
October 24, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29063293/two-mtor-inhibitors-rapamycin-and-torin-1-differentially-regulate-iron-induced-generation-of-mitochondrial-ros
#6
Hui Huang, Jun Chen, Huiru Lu, Mengxue Zhou, Zhifang Chai, Yi Hu
It is generally believed that gene-environment interaction may contribute to neurodegeneration. Of particular note is that iron overload may be one of the risk factors for neurodegeneration. However, the mechanisms underlying iron-associated neurotoxicity are not fully understood. Here we explored the effects of mechanistic target of rapamycin (mTOR) inhibition in iron-stressed human neuroblastoma cells. Two mTOR inhibitors, rapamycin and Torin 1, had similar effects in cells exposed to a relatively low concentration of iron...
October 23, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29063292/the-six-metal-binding-domains-in-human-copper-transporter-atp7b-molecular-biophysics-and-disease-causing-mutations
#7
REVIEW
Candan Ariöz, Yaozong Li, Pernilla Wittung-Stafshede
Wilson Disease (WD) is a hereditary genetic disorder, which coincides with a dysfunctional copper (Cu) metabolism caused by mutations in ATP7B, a membrane-bound P1B-type ATPase responsible for Cu export from hepatic cells. The N-terminal part (~ 600 residues) of the multi-domain 1400-residue ATP7B constitutes six metal binding domains (MBDs), each of which can bind a copper ion, interact with other ATP7B domains as well as with different proteins. Although the ATP7B's MBDs have been investigated in vitro and in vivo intensively, it remains unclear how these domains modulate overall structure, dynamics, stability and function of ATP7B...
October 23, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29052084/the-apoptotic-cytotoxic-and-genotoxic-effect-of-novel-binuclear-boron-fluoride-complex-on-endometrial-cancer
#8
Yasin Tülüce, Pawan Tareq Ahmed Lak, İsmail Koyuncu, Ahmet Kılıç, Mustafa Durgun, Halil Özkol
Endometrial cancer (EC) is one of the most common types of gynecologic cancer of the female genital tract; it considered being the fourth leading death factor among other types of cancer. Therefore, developing new anti-cancer agents are crucial for cancer treatment. Based on the potential of Schiff based complexes for the induction of apoptosis, Schiff base compounds, and their metal complexes displayed excellent anticancer properties. In this current study, antiproliferative activity of [L(BF2)2] as a novel binuclear boron-fluoride complex was examined to preliminary research in eight different cell lines, HELA, DU-145, PC3, DLD-1, ECC-1, PNT1-A, HT-29, and MCF-7, it was found to have a potent, suppressive effect on human endometrial adenocarcinoma cell line ECC-1...
October 19, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29022284/correction-to-lipophilic-gold-i-complexes-with-1-3-4-oxadiazol-2-thione-or-1-3-thiazolidine-2-thione-moieties-synthesis-and-their-cytotoxic-and-antimicrobial-activities
#9
Angelina Maria de Almeida, Bruno Assis de Oliveira, Pedro Pôssa de Castro, Camille Carvalho de Mendonça, Ricardo Andrade Furtado, Heloiza Diniz Nicolella, Vânia Lúcia da Silva, Cláudio Galuppo Diniz, Denise Crispim Tavares, Heveline Silva, Mauro Vieira de Almeida
This article has been corrected. One of the author names was given incorrect. Please find in this erratum the correct author name: "Heloiza Diniz Nicolella" that should be regarded as final by the reader.
October 11, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28994011/vanadium-v-complexes-with-hydrazides-and-their-spectroscopic-and-biological-properties
#10
Sadaf Sultan, Uzma Ashiq, Rifat Ara Jamal, Mohammad Mahroof-Tahir, Zara Shaikh, Bushra Shamshad, Mehreen Lateef, Lubna Iqbal
The present study explores the synthesis and inhibitory potential of vanadium(V) complexes of hydrazides (1c-12c) against oxidative enzymes including xanthine oxidase and lipoxygenase (LOX). In addition, non-enzymatic radical scavenging activities of these complexes were also determined. On the basis of spectral, elemental and physical data, synthesized vanadium(V) complexes are tentatively assigned to have an octahedral geometry with two hydrazide ligands and two oxo groups forming a negatively charged sphere complex with ammonium as counter ion...
October 9, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28993932/genome-wide-identification-of-cd-responsive-nramp-transporter-genes-and-analyzing-expression-of-nramp-1-mediated-by-mir167-in-brassica-napus
#11
Jin Guo Meng, Xian Duo Zhang, Shang Kun Tan, Kai Xuan Zhao, Zhi Min Yang
In plants, metal transporters are responsible for metal uptake, translocation and homeostasis. These metals include essential nutrients such as zinc (Zn) and manganese (Mn) or non-essential metals like cadmium (Cd) and lead (Pb). Although a few metal transporters have been well characterized in model plants, little is known about their functionality in rapeseed (Brassica napus). In the study, 22 NRAMP transporter genes from B. napus genome were identified and annotated using bioinformatics and high-throughput RNA-sequencing (RNA-seq)...
October 9, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28993928/tvznf1-is-a-c2h2-zinc-finger-protein-of-trichomonas-vaginalis
#12
José Luis Villalpando, Rodrigo Arreola, Jonathan Puente-Rivera, Elisa Azuara-Liceaga, Jesús Valdés, Lilia López-Canovas, Alma Villalobos-Osnaya, Maria Elizbeth Alvarez-Sánchez
The zinc fingers proteins (ZNF) are the largest family of DNA binding proteins and can act as transcriptional factors in eukaryotes. ZNF are implicated in activation in response to environmental stimulus by biometals such as Zn(2+). Many of these proteins have the classical C2H2 zinc finger motifs (C2H2-ZNFm) of approximately 30 amino acids, where a Zn(2+) ion is coordinated by two cysteine and two histidine residues. Trichomonas vaginalis is a protozoan parasite than responds to environmental changes including Zn(2+)...
October 9, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28993927/rhodium-ii-complex-with-2-benzoylpyridine-a-novel-potential-chemotherapeutic-drug-induces-cell-cycle-arrest-and-apoptosis-in-hepg2-cells
#13
Xuehong Wang, Yulan Li, Minglin Lin, Junfei Jin, Zhaoquan Huang
Rhodium (II) complex with 2-benzoylpyridine (Rh(L)2Cl2) is a new, synthetic, active metal-complex, which is produced by the reaction of 2-benzoylpyridine (L) with rhodium chloride hydrate (RhCl3·nH2O). The crystal structure was determined by X-ray diffraction which is mono-nuclear. In order to explore the biological properties of the novel complex, a series of studies were performed. The results showed that Rh(L)2Cl2 had the anti-tumor activity in HepG2 and other cell lines and has been shown to induce G1 cell cycle arrest and apoptosis in HepG2 cells...
October 9, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28986750/biocidal-properties-of-maltose-reduced-silver-nanoparticles-against-american-foulbrood-diseases-pathogens
#14
Mustafa Çulha, Şaban Kalay, Elif Sevim, Müberra Pinarbaş, Yıldız Baş, Rahşan Akpinar, Şengül Alpay Karaoğlu
Bee disease caused by spore-forming Paenibacillus larvae and Paenibacillus alvei is a serious problem for honey production. Thus, there is an ongoing effort to find an effective agent that shows broad biocidal activity with minimal environmental hazard. In this study, the biocidal effect of maltose reduced silver nanoparticles (AgNPs) is evaluated against American foulbrood and European foulbrood pathogens. The results demonstrate that the maltose reduced AgNPs are excellent short and long-term biocides against P...
October 6, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28986698/synthesis-spectroscopic-characterization-and-in-vitro-anticancer-activity-of-new-platinum-ii-complexes-with-some-thione-ligands%C3%A2-in-the-presence-of-triethylphosphine
#15
Mohammed Yagoub Jomaa, Muhammed Altaf, Saeed Ahmad, Gaurav Bhatia, Jatinder Singh, Saleh Altuwaijri, Anvarhusein A Isab
Seven new platinum(II) complexes (1-7) of triethylphosphine (Et3P) and thiones (L) with general formula, cis-[Pt(Et3P)2(L)2]Cl2 were prepared and characterized by elemental analysis, FTIR and NMR ((1)H, (13)C & (31)P) measurements. The analytical and spectroscopic data suggested the formation of the desired complexes. The complexes were tested for in vitro cytotoxicity against four cell lines: Hela (human cervical adenocarcinoma), MCF-7 (human breast carcinoma), A549 (human lung carcinoma), and HTC15 (human colon carcinoma)...
October 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28936772/proteome-characterization-of-copper-stress-responses-in-the-roots-of-sorghum
#16
Swapan Kumar Roy, Seong-Woo Cho, Soo Jeong Kwon, Abu Hena Mostafa Kamal, Dong-Gi Lee, Kabita Sarker, Moon-Soon Lee, Zhanguo Xin, Sun-Hee Woo
Copper (Cu) is a important micronutrient for plants, but it is extremely toxic to plants at high concentration and can inactivate and disturb protein structures. To explore the Cu stress-induced tolerance mechanism, the present study was conducted on the roots of sorghum seedlings exposed to 50 and 100 µM CuSO4 for 5 days. Accumulation of Cu increased in roots when the seedlings were treated with the highest concentration of Cu(2+) ions (100 μM). Elevated Cu concentration provoked notable reduction of Fe, Zn, Ca, and Mn uptake in the roots of sorghum seedlings...
October 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28894951/structural-and-functional-characterization-of-mercuric-reductase-from-lysinibacillus-sphaericus-strain-g1
#17
Amit Bafana, Farha Khan, Kaza Suguna
In response to the widespread presence of inorganic Hg in the environment, bacteria have evolved resistance systems with mercuric reductase (MerA) as the key enzyme. MerA enzymes have still not been well characterized from gram positive bacteria. Current study reports physico-chemical, kinetic and structural characterization of MerA from a multiple heavy metal resistant strain of Lysinibacillus sphaericus, and discusses its implications in bioremediation application. The enzyme was homodimeric with subunit molecular weight of about 60 kDa...
October 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28871443/mmp-7-cleaves-amyloid-%C3%AE-fragment-peptides-and-copper-ion-inhibits-the-degradation
#18
Masanari Taniguchi, Kazuki Matsuura, Rina Nakamura, Aya Kojima, Motomi Konishi, Toshifumi Akizawa
The extracellular deposition of amyloid β (Aβ) is known to be the fundamental cause of Alzheimer's disease (AD). Aβ1-42, generated by β-secretases from the amyloid precursor protein (APP), is the main component of neuritic plaque, and the aggregation of this protein is shown to be dependent to an extent on metal ions such as copper and zinc. However, the mechanism by which Cu(2+) affects the physicochemical properties of Aβ1-42 or the central nervous system is still under debate. A recent series of studies have demonstrated that both the soluble-type matrix metalloproteinases (MMP-2 and MMP-9) and the membrane-type matrix metalloproteinase (MT1-MMP) are capable of degrading Aβ peptides...
October 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28836023/studies-on-reaction-of-glutathionylcobalamin-with-hypochlorite-evidence-of-protective-action-of-glutathionyl-ligand-against-corrin-modification-by-hypochlorite
#19
Ilia A Dereven'kov, Sergei V Makarov, Nikita I Shpagilev, Denis S Salnikov, Oskar I Koifman
Glutathionylcobalamin (GSCbl), a tight complex of glutathione (GSH) with cobalamin(III), is readily oxidized to aquacobalamin by hypochlorite. Corrin macrocycle remains unmodified in the presence of threefold excess of hypochlorite, whereas aqua- and cyanocobalamins are partially transformed to chlorinated species under the same conditions. The suggested mechanism of reaction between GSCbl and hypochlorite involves subsequent oxidation of thiol and amino groups and dissociation of oxidized glutathione from Co(III)-ion...
October 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28819732/erratum-to-fructose-1-6-bisphosphate-reverts-iron-induced-phenotype-of-hepatic-stellate-cells-by-chelating-ferrous-ions
#20
Henrique Bregolin Dias, Gabriele Catyana Krause, Eamin Daidrê Squizani, Kelly Goulart Lima, Aline Daniele Schuster, Leonardo Pedrazza, Bruno de Souza Basso, Bianca Andrade Martha, Fernanda Cristina de Mesquita, Fernanda Bordignon Nunes, Márcio Vinícius Donadio, Jarbas Rodrigues de Oliveira
No abstract text is available yet for this article.
October 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
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