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Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine

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https://www.readbyqxmd.com/read/30014355/oxidative-stress-and-neurodegeneration-the-involvement-of-iron
#1
REVIEW
Alessia Carocci, Alessia Catalano, Maria Stefania Sinicropi, Giuseppe Genchi
Many evidences indicate that oxidative stress plays a significant role in a variety of human disease states, including neurodegenerative diseases. Iron is an essential metal for almost all living organisms due to its involvement in a large number of iron-containing proteins and enzymes, though it could be also toxic. Actually, free iron excess generates oxidative stress, particularly in brain, where anti-oxidative defences are relatively low. Its accumulation in specific regions is associated with pathogenesis in a variety of neurodegenerative diseases (i...
July 16, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30014354/variation-on-a-theme-investigating-the-structural-repertoires-used-by-ferric-uptake-regulators-to-control-gene-expression
#2
REVIEW
Sabina Sarvan, James Butcher, Alain Stintzi, Jean-François Couture
In every living organism, the control of metal homoeostasis is a tightly regulated process coordinated by several intertwined biological pathways. In many bacteria, the ferric uptake regulator (Fur) family of transcriptional factors (TFs) are key factors in controlling the expression of genes involved in metal homeostasis and can also regulate the expression of genes involved in responses to oxidative stresses. Since the crystallization of Escherichia coli Fur DNA binding domain, the crystal structure of several metalloregulators have been reported...
July 16, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30014353/chromium-malate-alleviates-high-glucose-and-insulin-resistance-in-l6-skeletal-muscle-cells-by-regulating-glucose-uptake-and-insulin-sensitivity-signaling-pathways
#3
Weiwei Feng, Yangyang Ding, Weijie Zhang, Yao Chen, Qian Li, Wei Wang, Hui Chen, Yun Feng, Ting Zhao, Guanghua Mao, Liuqing Yang, Xiangyang Wu
Previous study revealed that chromium malate improved the regulation of fasting blood glucose and insulin resistance in type 2 diabetic rats. In this study, the effect of chromium malate on anti-high-glucose and improve insulin resistance activities in L6 skeletal muscle cells with insulin resistance and its acting mechanism were investigated. Chromium malate showed direct anti-high-glucose activity in vitro. The glucose levels had a significant downward trend compared to chromium trichloride. Compared with model group, chromium malate could significantly promote the secretion levels of GLUT-4, Akt, Irs-1, PPARγ, PI3K and p38-MAPK, promote AMPKβ1 phosphorylation, and reduced the level of p-Irs-1 in L6 cells with insulin resistance...
July 16, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30014352/high-selenium-yeast-mitigates-aluminum-induced-cerebral-inflammation-by-increasing-oxidative-stress-and-blocking-no-production
#4
Changyu Cao, Xiaowen Li, Lei Qin, Junchong Luo, Mengdan Zhang, Zijian Ou, Kai Wang
High Selenium Yeast (SeY) serves many important roles with respect to the maintenance of normal nervous system functioning. Studies have reported the nerve inflammation induced by Aluminum (Al) was associated with the increase of mortality. However, in-depth studies are required to verify the hypothesized neuro-protective efficacy of SeY against Al-induced cerebral damage through modulation of the inflammatory response. Here, mice were treated with SeY (0.1 mg/kg) and/or Al (10 mg/kg) by oral gavage for 28 days...
July 16, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30014351/ferrous-and-ferric-differentially-deteriorate-proliferation-and-differentiation-of-osteoblast-like-umr-106-cells
#5
Kornkamon Lertsuwan, Ketsaraporn Nammultriputtar, Supanan Nanthawuttiphan, Supathra Phoaubon, Jomnarong Lertsuwan, Jirawan Thongbunchoo, Kannikar Wongdee, Narattaphol Charoenphandhu
The association between iron overload and osteoporosis has been found in many diseases, such as hemochromatosis, β-thalassemia and sickle cell anemia with multiple blood transfusion. One of the contributing factors is iron toxicity to osteoblasts. Some studies showed the negative effects of iron on osteoblasts; however, the effects of two biological available iron species, i.e., ferric and ferrous, on osteoblasts are elusive. Since most intracellular ionized iron is ferric, osteoblasts was hypothesized to be more responsive to ferric iron...
July 16, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30008026/selenised-yeast-sources-differ-in-their-capacity-to-protect-porcine-jejunal-epithelial-cells-from-cadmium-induced-toxicity-and-oxidised-dna-damage
#6
Sarah Lynch, Karina Horgan, Dermot Walls, Blánaid White
In recent years there has been increasing interest in the use of selenised yeast (Se-Y) as an antioxidant feed supplement. Here, three selenised yeast products are differentiated in terms of bioefficiency and the ameliorative effect on Cadmium (Cd) toxicity in porcine epithelial cells. A porcine digestion in vitro model was chosen to more accurately simulate the bioavailability of different Se-Y preparations, allowing a comprehensive understanding of the bio efficiency of each Se-Y compound in the porcine model...
July 14, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/30006888/effects-of-lead-and-lead-melatonin-exposure-on-protein-and-gene-expression-of-metal-transporters-proteins-and-the-copper-zinc-ratio-in-rats
#7
Karla J Soto-Arredondo, Juvencio Robles, Erik Díaz-Cervantes, Carolina Ruiz-Ramírez, Marco A García-Revilla, Katarzyna Wrobel, Kazimierz Wrobel, Mauricio Díaz-Muñoz, Isabel Méndez, Alberto Flores, Francisco Javier Acevedo-Aguilar, Minerva Martínez-Alfaro
Human lead (Pb) exposure induces many adverse health effects, including some related to lead accumulation in organs. Although lead bio-distribution in the body has been described, the molecular mechanism underlying distribution and excretion is not well understood. The transport of essential and toxic metals is principally mediated by proteins. How lead affects the expression of metal transporter proteins in the principal metal excretory organs, i.e., the liver and kidney, is unknown. Considering that co-administration of melatonin and lead reduces the toxic effects of lead and lead levels in the blood in vivo, we examined how lead and co-administration of lead and melatonin affect the gene and protein expression of metal transporter proteins (ZIP8, ZIP14, CTR1 and DMT1) in these organs...
July 13, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29974287/zinc-preconditioning-protects-against-renal-ischaemia-reperfusion-injury-in-a-preclinical-sheep-large-animal-model
#8
Dermot O'Kane, Luke Gibson, Clive N May, Justin du Plessis, Arthur Shulkes, Graham S Baldwin, Damien Bolton, Joseph Ischia, Oneel Patel
Ischaemia-reperfusion injury (IRI) during various surgical procedures, including partial nephrectomy for kidney cancer or renal transplantation, is a major cause of acute kidney injury and chronic kidney disease. Currently there are no drugs or methods for protecting human organs, including the kidneys, against the peril of IRI. The aim of this study was therefore to investigate the reno-protective effect of Zn2+ preconditioning in a clinically relevant large animal sheep model of IRI. Further the reno-protective effectiveness of Zn2+ preconditioning was tested on normal human kidney cell lines HK-2 and HEK293...
July 4, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29959651/inorganic-mercury-in-human-astrocytes-oligodendrocytes-corticomotoneurons-and-the-locus-ceruleus-implications-for-multiple-sclerosis-neurodegenerative-disorders-and-gliomas
#9
Roger Pamphlett, Stephen Kum Jew
Neurotoxic metals have been implicated in the pathogenesis of multiple sclerosis, neurodegenerative disorders and brain tumours but studies of the location of heavy metals in human brains are rare. In a man who injected himself with metallic mercury the cellular location of mercury in his brain was studied after 5 months of continuous exposure to inorganic mercury arising from metallic mercury deposits in his organs. Paraffin sections from the primary motor and sensory cortices and the locus ceruleus in the pons were stained with autometallography to detect inorganic mercury and combined with glial fibrillary acidic protein immunohistochemistry to identify astrocytes...
June 29, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29956040/mass-spectrometric-characterization-of-siderophores-produced-by-pseudomonas-taiwanensis-vlb120-assisted-by-stable-isotope-labeling-of-nitrogen-source
#10
Karen Scholz, Till Tiso, Lars M Blank, Heiko Hayen
The structures of three previously unknown siderophores produced by the fluorescent, biotechnologically relevant Pseudomonas taiwanensis (P. taiwanensis) VLB120 bacteria were elucidated by means of hydrophilic interaction liquid chromatography (HILIC) hyphenated to high-resolution tandem mass spectrometry (HRMS/MS). They could be verified as iron(III)- and aluminum(III) complexes as well as the protonated molecules of the siderophores formed by in-source fragmentation. The siderophores were separated according to their different acyl side chains and additionally according their central ions...
June 28, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29951879/iron-chelation-inhibits-cancer-cell-growth-and-modulates-global-histone-methylation-status-in-colorectal-cancer
#11
Lin-Lin Cao, Hangqi Liu, Zhihong Yue, Lianhua Liu, Lin Pei, Junxu Gu, Hui Wang, Mei Jia
Colorectal cancer (CRC) is one of the most common malignancies worldwide, and new treatment strategies for CRC are required because of the existing chemotherapy resistance. Iron chelators, which have been used widely for the treatment of iron-overload disease, were reported to exert anti-proliferative effects in cancer. However, the role of iron chelation in CRC was largely unknown. In this study, we found that the iron chelator DFO inhibited CRC cell growth significantly. In addition, the gene expression profile was greatly changed by DFO treatment, and many cell growth-related genes were dysregulated...
June 27, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29946993/antimicrobial-properties-of-ternary-eutectic-aluminum-alloys
#12
Claudia Hahn, Michael Hans, Christina Hein, Anne Dennstedt, Frank Mücklich, Petra Rettberg, Christine Elisabeth Hellweg, Lars Ingo Leichert, Christopher Rensing, Ralf Moeller
Several Escherichia coli deletion mutants of the Keio collection were selected for analysis to better understand which genes may play a key role in copper or silver homeostasis. Each of the selected E. coli mutants had a deletion of a single gene predicted to encode proteins for homologous recombination or contained functions directly linked to copper or silver transport or transformation. The survival of these strains on pure copper surfaces, stainless steel, and alloys of aluminum, copper and/or silver was investigated...
June 27, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29855746/correlation-between-na-k-ratio-and-electron-densities-in-blood-samples-of-breast-cancer-patients
#13
Ömer Topdağı, Ozan Toker, Sezgin Bakırdere, Ertuğrul Osman Bursalıoğlu, Ersoy Öz, Önder Eyecioğlu, Mustafa Demir, Orhan İçelli
The main purpose of this study was to investigate the relationship between the electron densities and Na/K ratio which has important role in breast cancer disease. Determinations of sodium and potassium concentrations in blood samples performed with inductive coupled plasma-atomic emission spectrometry. Electron density values of blood samples were determined via ZXCOM. Statistical analyses were performed for electron densities and Na/K ratio including Kolmogorov-Smirnov normality tests, Spearman's rank correlation test and Mann-Whitney U test...
May 31, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29855745/vanadium-quercetin-complex-attenuates-mammary-cancer-by-regulating-the-p53-akt-mtor-pathway-and-downregulates-cellular-proliferation-correlated-with-increased-apoptotic-events
#14
Souvik Roy, Sritama Banerjee, Tania Chakraborty
Flavonoid metal ion complexes have been deliberated in recent years and are considered as a new class of medicinal agents with enhanced therapeutic activity and low toxicity. Our study deals with chemotherapeutic effects of vanadium, when coordinated with the flavonoid quercetin on a defined model of chemically induced rat mammary carcinogenesis in vivo and on human breast cancer cell line MCF-7 in vitro. The characterization of the complex was achieved through UV-Visible, IR, and Mass spectra and antioxidant activity was assessed by DPPH, FRAP and ABTS methods...
May 31, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29767398/bioinformatic-analysis-of-the-metal-response-element-and-zinc-dependent-gene-regulation-via-the-metal-response-element-binding-transcription-factor-1-in-caco-2-cells
#15
Michael Francis, Arthur Grider
The purpose of this study was to determine the correlation between the position or number of metal regulatory elements (MREs) near gene transcriptional or translational start sites, and the strength of metal response element-binding transcription factor 1 (MTF-1) regulation. A secondary analysis was performed in silico on published results measuring the effects of Zn and MTF-1 on transcriptional regulation of genes (n = 120) in the Caco-2 cell line. MRE sequence variations throughout the human genome were sorted using a position weight matrix...
May 16, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29767397/the-potential-role-of-spherocrystals-in-the-detoxification-of-essential-trace-metals-following-exposure-to-cu-and-zn-in-the-fighting-conch-strombus-lobatus-pugilis
#16
Jean-Marie Volland, Paco Bustamante, Dalila Aldana Aranda, Olivier Gros
Crypt cells-one of the three cell types composing Strombidae digestive tubules-are characterized by the presence of numerous metal-containing phosphate granules termed spherocrystals. We explored the bioaccumulation and detoxification of metals in Strombidae by exposing wild fighting conch Strombus pugilis for 9 days to waterborne CuSO4 and ZnSO4 . The total amount of Cu and Zn was determined in the digestive gland and in the rest of the body by Inductively Coupled Plasma (ICP) analyses. The digestive gland spherocrystal metal content was investigated based on the semi-quantitative energy dispersive X-ray (EDX) elemental analysis...
May 16, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29767396/are-lactoferrin-receptors-in-gram-negative-bacteria-viable-vaccine-targets
#17
Clement Chan, Vahid F Andisi, Dixon Ng, Nick Ostan, Warren K Yunker, Anthony B Schryvers
A number of important Gram-negative pathogens that reside exclusively in the upper respiratory or genitourinary tract of their mammalian host rely on surface receptors that specifically bind host transferrin and lactoferrin as a source of iron for growth. The transferrin receptors have been targeted for vaccine development due to their critical role in acquiring iron during invasive infection and for survival on the mucosal surface. In this study, we focus on the lactoferrin receptors, determining their prevalence in pathogenic bacteria and comparing their prevalence in commensal Neisseria to other surface antigens targeted for vaccines; addressing the issue of a reservoir for vaccine escape and impact of vaccination on the microbiome...
May 16, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29766365/iron-overload-prevents-oxidative-damage-to-rat-brain-after-chlorpromazine-administration
#18
Natacha E Piloni, Andres A Caro, Susana Puntarulo
The hypothesis tested is that Fe administration leads to a response in rat brain modulating the effects of later oxidative challenges such as chlorpromazine (CPZ) administration. Either a single dose (acute Fe overload) or 6 doses every second day (sub-chronic Fe overload) of 500 or 50 mg Fe-dextran/kg, respectively, were injected intraperitoneally (ip) to rats. A single dose of 10 mg CPZ/kg was injected ip 8 h after Fe treatment. DNA integrity was evaluated by quantitative PCR, lipid radical (LR· ) generation rate by electron paramagnetic resonance (EPR), and catalase (CAT) activity by UV spectrophotometry in isolated brains...
May 15, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29766364/binding-of-cd-ii-pb-ii-and-zn-ii-to-a-type-1-metallothionein-from-maize-zea-mays
#19
Lian Duan, Jing-Jing Kong, Tong-Qing Wang, Yue Sun
Metallothioneins (MTs) are a family of ubiquitous, low-molecular-mass, cysteine-rich proteins that play a significant role in maintaining intracellular metal homeostasis, eliminating metal toxification, and protecting cells against oxidative damages. Research activity on plant MTs, although known for 30 years, has only moderately increased in the past few years. In this study, a type 1 MT from maize (Zea mays) (ZmMT1) was successfully expressed in Escherichia coli strain BL21 (DE3). The UV absorption spectra recorded after the reconstitution of apo-ZmMT1 with different metals demonstrated that ZmMT1 can coordinate up to six Zn(II) ions, six Cd(II) ions, and even higher amounts of Pb(II)...
May 15, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29761254/catroxmp-ii-a-heme-modulated-fibrinogenolytic-metalloproteinase-isolated-from-crotalus-atrox-venom
#20
Montamas Suntravat, Paul R Langlais, Elda E Sánchez, Vance G Nielsen
It has been recently demonstrated that the hemotoxic venom activity of several species of snakes can be inhibited by carbon monoxide (CO) or a metheme forming agent. These and other data suggest that the biometal, heme, may be attached to venom enzymes and may be modulated by CO. A novel fibrinogenolytic metalloproteinase, named CatroxMP-II, was isolated and purified from the venom of a Crotalus atrox viper, and subjected to proteolysis and mass spectroscopy. An ion similar to the predicted singly charged m/z of heme at 617...
May 14, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
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