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Oncology Research

He-Peng Cheng, Qian Liu, Yang Li, Xiao-Dong Li, Chao-Yang Zhu
Protein disulfide isomerases A6 (PDIA6) belongs to the PDI family. Recently, PDIA6 was found to have a close association with various cancers. However, there has been little investigation into the biological functions of PDIA6 in bladder cancer (BC). In this study, we explored the expression pattern and functional significance of PDIA6 in BC. We found that PDIA6 was overexpressed in BC tissues and cell lines. The in vitro study showed that PDIA6 downregulation significantly inhibited BC proliferation and invasion...
October 18, 2016: Oncology Research
Qifang Long, Weipei Zhu, Jundong Zhou, Jinchang Wu, Weixian Lu, Cui Zheng, Dongmei Zhou, Ling Yu, Ru Yang
Ovarian cancer is one of the most lethal malignant gynecologic tumors with a high relapse rate worldwide. Cancer stem cells (CSC) have been identified in ovarian cancer and other malignant tumors as a small population of cells that are capable of self-renew and multi-differentiation. CD133 positive (CD133(+)) ovarian cancer stem cells have been reported to be more tumorigenic and more resistant to chemotherapeutic treatment. Thus, CD133 has emerged as one of the most promising therapeutic markers for ovarian cancer treatment...
October 18, 2016: Oncology Research
Hongwei Tan, Zhaoyang Liu, Jin Qi, Guanghua Chu
Tripartite motif 16 (TRIM16), a member of the RING B-box coiled-coil (RBCC)/tripartite totif (TRIM) protein family, has been shown to play a role in tumor development and progression. However, the role of TRIM16 in ovarian cancer has never been revealed. Thus, in this study, we investigated the roles and mechanisms of TRIM16 in ovarian cancer. Our results demonstrated that TRIM16 expression was low in ovarian cancer cell lines. In addition, overexpression of TRIM16 significantly inhibited the migration and invasion in vitro, as well as suppressed the epithelial-mesenchymal transition (EMT) phenotype in ovarian cancer cells...
October 12, 2016: Oncology Research
Xianglei Li, Yanhua Li, Hong Lu
MiRNAs are involved in breast cancer initiation and progression. In this study, we investigated the role of miR-1193, a newly found and poorly studied miRNA, in the proliferation and invasion of human breast cancer cells. Our results showed that compared with the adjacent tissues and MCF-10A human normal breast cells, miR-1193 was sharply reduced in breast cancer tissues and 5 breast cancer cell lines, including MDA-MB-231, MDA-MB-468, MDA-MB-435, SKBR3, and MCF-7. The oligo miR-1193 mimic or anta-miR-1193 was then transfected into MDA-MB-231 and MCF-7 breast cancer cell lines...
October 11, 2016: Oncology Research
Yang Zhao, Wenxia Chen, Weiliang Zhu, Hui Meng, Jie Chen, Jian Zhang
The purpose of this study was to identify the role of interferon regulatory factor 7 (IRF7) in the bone metastasis of prostate cancer. Herein, we demonstrated the lower expression of IRF7 in bone metastases of prostate cancer. Overexpression of IRF7 in prostate cancer cells had a marked effect on inhibiting bone metastases but not on tumor growth in xenograft nude mice. While in vitro, up-regulation of IRF7 had little effect on the malignant phenotype of prostate cancer cells including proliferation, apoptosis, migration, and invasion...
October 11, 2016: Oncology Research
Cuiyue Wang, Zhen Feng, Kaitong Jiang, Xiuli Zuo
Our goal was to determine the roles and regulatory mechanism of microRNA-935 (miR-935) in the progression of pancreatic cancer. The results showed that, compared with normal pancreatic tissues and cells, the expression of miR-935 was markedly upregulated while INPP4A expression was obviously downregulated in pancreatic cancer tissues and PANC-1 cells. After transfection with miR-935 inhibitor, miR-935 was significantly suppressed, and suppression of miR-935 significantly inhibited cell proliferation, suppressed cell migration, and induced cell apoptosis of pancreatic cancer cells...
October 11, 2016: Oncology Research
Zhongwei Wang, Yali Wang, Hongtao Ren, Yingying Jin, Ya Guo
Zinc and ring finger 3 (ZNRF3), which belongs to the E3 ubiquitin ligase family is involved in the progression and development of cancer. However, the expression and function of ZNRF3 in human nasopharyngeal carcinoma (NPC) remains unclear. Thus, the aim of this paper was to investigate the role of ZNRF3 in human nasopharyngeal carcinoma. Our results showed that ZNRF3 was downregulated in nasopharyngeal carcinoma cell lines. Restoration of ZNRF3 significantly inhibited the proliferation of NPC cells and tumor xenograft growth in vivo...
October 11, 2016: Oncology Research
Sheqing Ji, Bin Zhang, Ye Kong, Fei Ma, Yawei Hua
MicroRNAs (miRNAs) play a crucial role in the development and progression of human cancers, including gastric cancer (GC). The discovery of miRNAs may provide a new and powerful tool for studying the mechanism, diagnosis, and treatment of GC. In this study, we aimed to investigate the role of miR-326 in the development and progression of GC. Quantitative PCR (qPCR) was used to measure the expression level of miR-326 in GC tissues and cell lines. We found that miR-326 was significantly downregulated during GC...
October 11, 2016: Oncology Research
Yan Zhang, Gang Cao, Qing-Gong Yuan, Jun-Hui Li, Wen-Bin Yang
Empty spiracles homeobox 2 (EMX2) is a homeo-domain-containing transcription factor that plays an essential role in tumorigenesis. However, to the best of our knowledge, the role of EMX2 in human colorectal cancer (CRC) is still unclear. Thus, the aim of this study was to investigate the expression and role of EMX2 in CRC. Our results demonstrated that the expression of EMX2 was greatly decreased in CRC tissues and cell lines. Overexpression of EMX2 significantly inhibited the proliferation in vitro and CRC tumor growth in nude mice...
October 5, 2016: Oncology Research
Zhe Huang, Yong Feng
Cancer cell-derived exosomes have been actively released into the tumor microenvironment with pleiotropic roles in tumor growth and metastasis, including angiogenesis and immune modulation. However, the functions and underlying mechanisms of exosomes shed by colorectal cancer (CRC) cells under hypoxic conditions remains unknown. Here, we found that exosomes derived from hypoxic CRC cells promoted the proliferation and migration of endothelial cells. Suppression of exosome secretion through RAB27a knockdown in CRC cells inhibited exosomal induced proliferation and migration of endothelial cells...
October 5, 2016: Oncology Research
Fuqiang Wan, Li Peng, ChaoYu Zhu, XinFa Zhang, FangWen Chen, Tao Liu
Latent transforming growth factor (TGF) beta-binding protein 2 (LTBP2) is one of four proteins in the LTBP family of proteins (LTBP-1-4) and was shown to play a vital role in tumorigenesis. However, little is known regarding the functional role of LTBP2 in thyroid carcinoma. Therefore, the current study aimed to evaluate the effect of LTBP2 expression on the proliferation, invasion, and tumorigenesis in thyroid carcinoma cells, and to explore the molecular mechanism of LTBP2 in tumor progression. Our results showed that the expression of LTBP2 is upregulated in human thyroid carcinoma and cell lines...
October 5, 2016: Oncology Research
Jianping Shi, Yi Zhang, Nuyun Jin, Yuqin Li, Shengtian Wu, Leiming Xu
Gastric carcinoma is one of the most common malignancies in men and microRNA plays a critical role in regulating the signaling networks of gastric carcinoma tumorigenesis and metastasis. We first report the functional characteristics of miR-221-3p in gastric carcinoma. Quantification in gastric carcinoma cell lines and tumor samples reveals significantly increasing miR-221-3p expression. Moreover, a high level of miR-221-3p is correlated with a poor prognosis for gastric carcinoma patients. Ectopic miR-221-3p expression significantly promotes gastric carcinoma cell proliferation, invasion, and sphere formation, while silencing miR-221-3p significantly inhibits these abilities in gastric carcinoma cells...
October 5, 2016: Oncology Research
Hongbao Liu, Binya Shi, Yu Yan, Ligang Niu, Yuhui Zhou, Hui Cai, Guanqun Ge
Breast cancer side population (SP) cells display distinctly higher CXCR4 and ABCG2 expression levels, sphere formation efficiency (SFE), and growth capacity, even under hypoxic conditions. Inhibition of CXCR4 by the inhibitor AMD3100 suppressed SFE and cell growth under hypoxia. ABCG2 confers the major phenotype of SP cells, and knockdown of ABCG2 also suppressed SFE and the growth of hypoxic SP cells. In addition, we found that CXCR4 promoted the expression of c-Jun, a putative transcription factor for ABCG2...
September 30, 2016: Oncology Research
Xinyang Liu, Zhichao Wang, Guoliang Zhang, Qikun Zhu, Hui Zeng, Tao Wang, Feng Gao, Zhan Qi, Jinwen Zhang, Rui Wang
Esophageal cancer is one of the most common types of cancer and it has a poor prognosis. The molecular mechanisms of esophageal cancer progression remain largely unknown. In this study, we aimed to investigate the clinical significance and biological function of tumor necrosis factor receptor associated factor 6 (TRAF6) in esophageal cancer. Expression of TRAF6 in esophageal cancer was examined and its correlation with clinicopathological factors and patient prognosis was analyzed. A series of functional and mechanism assays were performed to further investigate the function and underlying mechanisms in esophageal cancer...
September 30, 2016: Oncology Research
Susan Azizmohammadi, Sima Azizmohammadi, Aghdas Safari, Maria Kaghazian, Mina Sadrkhanlo, Vahid Behnod, Mehri Seifoleslami
The investigation of specific genes will establish more useful biomarkers for accurate detection and management of gynecological cancers, especially patients with cervical cancer (CCP). The aim of this study was to evaluate the expression level of RIPK4 and EZH2 messenger RNA (RIPK4 and EZH2 mRNA) in CCP. Expression of RIPK4 and EZH2 in the tissues was determined by immunohistochemistry and qRT-PCR methods. Correlations of RIPK4 and EZH2 mRNA with clinical and pathological parameters were analyzed using the Fisher's exact test...
September 30, 2016: Oncology Research
Jihong Sun, Jingjing Li, Weiguo Zhang, Juan Zhang, Shenjie Sun, Guiqi Li, Hengliang Song, Daguo Wan
Gastric cancer (GC) is the fourth most common cancer globally. Recently, microRNAs (miRNAs) have been suggested to be closely associated with tumorigenesis. Aberrant expression of miR-509-3p has been reported in cancer studies. However, the expression and mechanism of its function in gastric cancer remains unclear. Here, we showed that miR-509-3p was downregulated in gastric cancer specimens, which was associated with overall survival. Functional investigations demonstrated that the overexpression of miR-509-3p inhibited the migration and proliferation of the gastric cancer cells...
September 30, 2016: Oncology Research
Feng Jiang, Dengfeng Zhang, Guojun Li, Xiao Wang
DDX46, a member of the DEAD-box (DDX) helicase family, is involved in the development of several tumors. However, the exact role of DDX46 in osteosarcoma and the underlying mechanisms in tumorigenesis remain poorly understood. Thus, in the present study, we explored the role of DDX46 in osteosarcoma and the underlying mechanisms. Our results demonstrated that the expression levels of DDX46 in both mRNA and protein were greatly elevated in human osteosarcoma tissues and cell lines. Knockdown of DDX46 obviously inhibited osteosarcoma cell proliferation and tumor growth in vivo...
September 30, 2016: Oncology Research
Xiaorui Liu, Jingjing Li, Zujiang Yu, Juan Li, Ranran Sun, Quancheng Kan
Hepatocellular carcinoma (HCC) is the most common cancer in the world. MicroRNAs (miRNAs) are a type of small noncoding RNA that can regulate the expression of target genes under physiological and pathophysiological conditions. Aberrant expression of MicroRNA-935 (MiR-935) has been reported in cancer studies. However, its expression and mechanism in hepatocellular carcinoma remain unclear. In our study, we found that miR-935 was upregulated in liver cancer tissues and cells. Overexpression of miR-935 in liver cells promoted cell proliferation, tumorigenesis, and cell cycle progression, whereas inhibition of miR-935 reduced cell proliferation, tumorigenicity, and cell cycle progression...
September 30, 2016: Oncology Research
Ying Liu, Hui Lv, Xiaoying Wu, Jun Zhou, Ying Shi, Jifang Wen
Breast cancer is the leading cause of cancer deaths in females all over the world, mainly resulted from metastasis. Previous studies have revealed that Repressor Element-1 (RE-1) Silencing Transcription (REST) acted as a tumor suppressor in breast cancer. However, the mechanism by which REST is regulated remains unknown and its role in the metastasis in breast cancer cells remains unclear. In the present study, we showed that the expression of REST was lower in breast cancer samples than that of adjacent samples by immunohistochemical analysis, which may be due to hypermethylation of the REST promoter...
September 30, 2016: Oncology Research
Erkun Guo, Xiaopeng Liu
Signal peptide CUB EGF-like domain-containing protein 2 (SCUBE2), a member of the SCUBE family of proteins, was recently found to play an important role in cancer development. However, little is known regarding its biological function in glioma. In the present study, we investigated the effect of SCUBE2 on glioma and explored its relevant mechanisms. The study showed that SCUBE2 had a low expression in glioma tissue and cell lines. SCUBE2 overexpression inhibited glioma cell proliferation in vitro and in vivo as well as suppressed glioma cell migration and invasion in vitro...
September 30, 2016: Oncology Research
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