journal
MENU ▼
Read by QxMD icon Read
search

Oncology Research

journal
https://www.readbyqxmd.com/read/28550680/elemene-increases-autophagic-apoptosis-and-drug-sensitivity-in-human-cisplatin-ddp-resistant-lung-cancer-cell-line-spc-a-1-ddp-by-inducing-beclin-1-expression
#1
Kun Zhou, Liping Wang, Ruirui Cheng, Xia Liu, Shengya Mao, Yan Yan
Drug resistance is the major obstacle for the successful therapy of lung adenocarcinoma. It was suggested that ß-elemene, a major isoform of elemene, could reverse the drug resistance in lung cancer cells. However, the underlying mechanisms remains poorly known. Here, we aimed to investigate whether elemene is involved in the cisplatin (DDP)-resistance of lung adenocarcinoma cells and further explore the underlying mechanism. The results showed that human lung adenocarcinoma cell line SPC-A-1 and its DDP-resistant strain SPC-A-1/DDP had a similar sensitivity to elemene treatment...
May 23, 2017: Oncology Research
https://www.readbyqxmd.com/read/28550682/long-noncoding-rna-anril-promotes-cervical-cancer-development-by-acting-as-a-sponge-of-mir-186
#2
Jun-Jun Zhang, Dan-Dan Wang, Chen-Xiang Du, Yan Wang
Cervical cancer is a common malignancy of female reproductive system. Long non-coding RNA (lncRNA) has been reported tomodulate tumor progression in multiple cancers. The lncRNA antisense non-coding RNA in the INK4 locus (ANRIL) has been testified as oncogenic molecular in series tumors, however, the function and underlying mechanism involved in cervical cancer oncogenesis is still unclear. In present study, RT-PCR showed that ANRIL expression was significantly up-regulated in cervical cancer tumors and cell lines...
May 22, 2017: Oncology Research
https://www.readbyqxmd.com/read/28550679/downregulation-of-src-kinase-signaling-inhibitor-1-srcin1-expression-by-microrna-32-promotes-proliferation-and-epithelial-mesenchymal-transition-in-human-liver-cancer-cells
#3
Ren Chen, Jin-Yao Liao, Jing Huang, Wen-Li Chen, Xiao-Jun Ma, Xiao-Dan Luo
MicroRNAs play an important role in regulating gene expression by binding to the 3' UTR of target mRNAs. In this studywe have made an attempt to assess the molecular mechanisms by which miR-32 suppresses the expression of SRCIN1, thereby leading to promotion of proliferation and epithelial-mesenchymal transition of human liver cancer cells. Human liver cancer cell lines HepG2 were transfected with miR-32 mimics and its control. The HepG2 cell lines were the assessed for miR-32 expression. The transfected cell lines were then studied for SRCIN1 expression by luciferase assay, effect of transfection on cell proliferation and finally epithelial-mesenchymal transition...
May 22, 2017: Oncology Research
https://www.readbyqxmd.com/read/28550687/tanshinone-suppresses-arecoline-induced-epithelial-mesenchymal-transition-in-oral-submucous-fibrosis-by-epigenetically-reactivating-the-p53-pathway
#4
Lian Zheng, Zhen-Jie Guan, Wen-Ting Pan, Tian-Fang Du, Yu-Jia Zhai, Jia Guo
Oral submucous fibrosis (OSF) induced by the chewing of areca nut has been considered as a precancerous lesion with a higher probability of developing oral squamous cell carcinoma. Tanshinone (TSN) is the main component extracted from Salvia miltiorrhiza, a traditional Chinese medicine, which was found to have diverse pharmacological effects such as anti-inflammatory and anti-tumor effects. In current study, we aim to identify inhibitory effects and the underlying mechanism of Tanshinone on OSF progress. We found that treatment of TSN inhibited arecoline-mediated proliferation of primary human oral mucosal fibroblasts, and reversed the promotive effects of arecoline on EMT process...
May 21, 2017: Oncology Research
https://www.readbyqxmd.com/read/28550686/microrna-186-suppresses-cell-proliferation-and-metastasis-through-targeting-sentrin-specific-protease-1-in-renal-cell-carcinoma
#5
Dan Jiao, Man Wu, Lei Ji, Feng Liu, Yingying Liu
Recent evidence suggests that dysregulation of microRNAs are associated with the development of multiple malignancies.miR-186 has been reported as a critical cancer regulator in several types of cancers. However, its functional significance and molecular mechanism underlying renal cell carcinoma (RCC) remains unknown. In this study, our results showed that miR-186 expression was dramatically downregulated in RCC tissues and cell lines compared to that in adjacent normal tissues and cell lines. Overexpression of miR-186 significantly inhibited cell growth, colony formation, cell invasion, caused cell cycle arrest at G0/G1 phase, and induced cell apoptosis as detected by MTT, colony formation, Transwell assay, and flow cytometry assays in RCC cells...
May 21, 2017: Oncology Research
https://www.readbyqxmd.com/read/28550685/long-noncoding-rna-camta1-promotes-proliferation-and-mobility-of-human-breast-cancer-cell-line-mda-mb-231-via-targeting-mir-20b
#6
Pengwei Lu, Yuanting Gu, Lin Li, Fang Wang, Xue Yang, Yunqing Yang
Breast cancer is a serious threat to women's physical and psychological health. Long non-coding RNA CAMTA1 (LncCAMTA1)was believed to be related with tumor progression, but its role in breast cancer is not clear. Human breast cancer cell line MDA-MB-231 was used to investigate effect of LncCAMTA1 on cell viability, migration/invasion, and apoptosis. Expression of LncCAMTA1, miR-20b and VEGF in MDA-MB-231were measured after corresponding transfections. Binding effects between LncCAMTA1 and miR-20b, miR-20b and VEGF 3'UTR were measured...
May 21, 2017: Oncology Research
https://www.readbyqxmd.com/read/28550684/long-noncoding-rna-ccat2-knockdown-suppresses-tumorous-progression-by-sponging-mir-424-in-epithelial-ovarian-vancer
#7
Fu Hua, Chang-Hua Li, Xiao-Gang Chen, Xiao-Ping Liu
Epithelial ovarian cancer (EOC) is the one of most common gynecological malignant tumor with highest mortality, meanwhile, series of lncRNAs have been validated to play vital role in EOC tumorigenesis. Colon cancer-associated transcript 2 (CCAT2) has been verified as oncogenic lncRNA in multiple tumors, however, the role of CCAT2 in EOC genesis is still unclear. The purpose of present study is to probe the function of CCAT2 on EOC. Preliminary experiments found that CCAT2 expression was significantly up-regulated in EOC tissue and cell lines compared to noncancerous tissue and cells...
May 21, 2017: Oncology Research
https://www.readbyqxmd.com/read/28550678/knockdown-of-long-noncoding-rna-lncrna-metastasis-associated-lung-adenocarcinoma-transcript-1-malat1-inhibits-proliferation-migration-and-invasion-and-promoted-apoptosis-by-targeting-mir-124-in-retinoblastoma
#8
Shujun Liu, Guigang Yan, Junfu Zhang, Lianzhi Yu
Evidence suggests that the long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)is upregulated in cancer tissues and its elevated expression is associated with hyper-proliferation. However, the underlying mechanisms regarding the role of MALAT1 in retinoblastoma (RB) remains unclear. This study aimed to explore the functional role of MALAT1 in RB by targeting miR-124. Results showed that the expression of - MALAT1 was significantly higher in Y79 cell line than ARPE-19 cell line (P<0...
May 21, 2017: Oncology Research
https://www.readbyqxmd.com/read/28550688/long-noncoding-rna-crnde-prc2-participated-in-the-radiotherapy-resistance-of-human-lung-adenocarcinoma-through-targeting-p21-expression
#9
Ming Zhang, Change Gao, Yi Yang, Gaofeng Li, Jian Dong, Yiqin Ai, Nan Chen, Wenhui Li
Long noncoding RNAs (lncRNAs), as new class of functional regulators involved in human tumorigenesis, have been attracting increasing attention of researchers. The lncRNA Colorectal Neoplasia Differentially Expressed (CRNDE), transcribed from chromosome 16 on the strand opposite to the adjacent IRX5 gene, were originally found to be increased in CRC and was reported abnormal expressed in many cancers. However, its potential role and molecular mechanism underlying radioresistant phenotype formation of lung adenocarcinoma (LAD) remains unclear...
May 17, 2017: Oncology Research
https://www.readbyqxmd.com/read/28550683/oncogenic-role-of-microrna-30b-5p-in-glioblastoma-through-targeting-proline-rich-transmembrane-protein-2
#10
Zhongjun Li, Junxiu Guo, Yujie Ma, Zhixiong Lin, Longbo Zhang
MicroRNAs (miRs) have been found to play promoting or suppressive roles in different human cancers. However, the exactregulatory mechanism of miR-30b in glioblastoma still remains unknown. Here we showed that the expression of miR-30b was significantly increased in glioblastoma tissues and cell lines. Moreover, high expression of miR-30b was significantly associated with shorter survival time of glioblastoma patients. Knockdown of miR-30b caused a significant reduction in the proliferation, migration, and invasion of U87 and A172 cells...
May 17, 2017: Oncology Research
https://www.readbyqxmd.com/read/28492141/procaine-inhibits-proliferation-and-migration-of-colon-cancer-cells-through-inactivation-of-the-erk-mapk-fak-pathways-by-regulation-of-rhoa
#11
Chang Li, Shuohui Gao, Xiaoping Li, Chang Li, Lianjun Ma
Colon cancer is one of the lethal varieties of cancer. Chemotherapy remains to be one of the principal treatment approaches for colon cancer. Anticancer activity of procaine (PCA), which is a local anesthetic drug, has been explored in different studies. In our study, we aimed to explore the anticancer effect of PCA on colon cancer and its underlying mechanism. The results showed that PCA significantly inhibited cell viability, increased the percentage of apoptotic cells and decreased the expression level of RhoA in HCT116 cells in a dose dependent manner (P<0...
May 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28492139/histone-demethylase-jarid1b-is-overexpressed-in-osteosarcoma-and-upregulates-cyclin-d1-expression-via-demethylation-of-h3k27me3
#12
Wei Wang, Ke Zheng, Yi Pei, XiaoJing Zhang
JARID1B has been proven up-regulated in many human malignancies and correlated with tumor progression. However, its expression and clinical significance in osteosarcoma is still unclear. Thus, the aim of this study was to explore the effects of JARID1B in osteosarcoma tumorigenesis and development. In this study, we found that the expression levels of JARID1B in osteosarcoma tissues were significantly higher than those in corresponding noncancerous bone tissues. In addition, JARID1B up-regulation more frequently occurred in osteosarcoma specimens with poor prognosis...
May 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28492138/long-noncoding-rna-schlap1-accelerates-the-proliferation-and-metastasis-of-prostate-cancer-via-targeting-mir-198-and-promoting-the-mapk1-pathway
#13
Ye Li, Haihong Luo, Nan Xiao, Jianmin Duan, Zhiping Wang, Shuanke Wang
Prostate cancer has become the most commonly diagnosed and the second leading cause of cancer-related deaths in males.The long non-coding RNA SChLAP1 (second chromosome locus associated with prostate-1) has been found overexpressed in a subset of prostate cancers; however the significance and mechanism of SChLAP1 in prostate cancer is not well-known. In this study we explored the role of SChLAP1 in prostate cancer tissues, cell lines and mouse models. The effects of SChLAP1 on miR-198 and MAPK1 were specifically examined...
May 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28492136/inhibition-of-erk1-2-signaling-impairs-the-promoting-effects-of-tgf-%C3%A3-1-on-hepatocellular-carcinoma-cell-invasion-and-epithelial-mesenchymal-transition
#14
Ling Liu, Nianfeng Li, Qi Zhang, Jixiang Zhou, Ling Lin, Xinxin He
TGF-ß and ERK signaling have been implicated in various human cancers including hepatocellular carcinoma, but the underlying mechanism remains largely unclear. In this study, we aimed to explore the role of ERK1/2 in the regulation of TGF-ß's promoting and suppressive activities in HCC cells. Our data showed that treatment with TGF-ß1 enhanced invasion and epithelial-mesenchymal transition (EMT) in HCC HepG2 cells, accompanied with increased MMP9 production and activation of Smad2/3 and ERK1/2, but inhibited tumor cell proliferation...
May 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28548636/long-non-coding-rna-uca1-targets-mir-122-to-promote-proliferation-migration-and-invasion-of-glioma-cells
#15
Yang Sun, Jun-Gong Jin, Wei-Yang Mi, Hao Wu, Shi-Rong Zhang, Qiang Meng, Shi-Tao Zhang
Glioma is the most common and lethal intracranial malignant tumor. Long non-coding RNAs (lncRNAs) have been identifiedas pivotal regulators in the tumorigenesis of glioma. However, the role of lncRNA urothelial carcinoma-associated 1 (UCA1) in the gliomagenesis is still unknown. The purpose of this study is to investigate the underlying function of UCA1 on glioma genesis. Results demonstrated that UCA1 was up-regulated in glioma tissue and indicated the poor prognosis. UCA1 knockdown induced by si-UCA1 significantly suppressed the proliferative, migrative and invasive activity of glioma cell lines (U87 and U251)...
May 5, 2017: Oncology Research
https://www.readbyqxmd.com/read/28477403/micro-rna-21-regulates-cancer-associated-fibroblast-mediated-frug-resistance-in-pancreatic-cancer
#16
Lulin Zhang, Jun Yao, Wenyao Li, Ce Zhang
Pancreatic adenocarcinoma (PDAC) is one of the leading cause of cancer death due to its highly aggressive biological nature and resistance to chemotherapies. Former study also indicated that miR-21 in cancer-associated fibroblasts (CAFs) is an important regulator of their activation. However, whether miR-21 in CAFs would regulate PDAC's tumor microenvironment and leading to drug resistance remain unknown. In this study, we evaluated the relationship among CAFs activation, miR-21 expression level and drug resistance using PDAC patient tumor samples...
May 5, 2017: Oncology Research
https://www.readbyqxmd.com/read/28474572/lncrna-gm15290-promotes-cell-proliferation-and-invasion-in-non-small-cell-lung-cancer-through-directly-interacting-with-and-suppressing-the-tumor-suppressor-mir-615-5p
#17
Yu Dong, Xiaoying Huo, Ruiying Sun, Zhiyan Liu, Miaoyi Huang, Shuanying Yang
Long non-coding RNAs (lncRNAs) have been involved in occurrence and progression of multiple cancers. In this study, weinvestigated the role of lncRNA Gm15290 in the proliferation and invasion of non-small cell lung cancer (NSCLC) cells. First, we found that lncRNA Gm15290 was markedly upregulated in tumor tissues from NSCLC patients and NSCLC cell lines, compared with adjacent normal tissues and normal lung cell line HBE respectively. Then, different concentrations of pcDNA-Gm15290 expression vector and Gm15290 siRNA were respectively transfected into A549 NSCLC cells...
May 5, 2017: Oncology Research
https://www.readbyqxmd.com/read/28474573/corilagin-induces-high-levels-of-apoptosis-in-the-temozolomide-resistant-t98g-glioma-cell-line
#18
Roberta Milani, Eleonora Brognara, Enrica Fabbri, Alessia Finotti, Monica Borgatti, Ilaria Lampronti, Giovanni Marzaro, Adriana Chilin, Kenneth Ka-Ho Lee, Stanton Hon-Lung Kok, Chung-Hin Chui, Roberto Gambari
Glioblastoma multiforme (GBM), a malignant tumor of the central nervous system, has a high mortality rate; no curativetreatment is presently available and the most commonly used chemiotherapeutic drug, the alkylating agent temozolomide (TMZ), is only able to increase life expectancy and is often associated with drugresistance. Therefore, an urgent need does exist for novel drugs aimed at treating gliomas. In the present study we obtained three major results using corliagin: (a) demonstrate that it inhibits the growth of U251 glioma cells through activation of the apoptotic pathway; (b) demonstrate that it is also active on temozolomideresistant T98G glioma cells; (c) demonstrate that when used in combination with temozolomide on T98G glioma cells a higher level of pro-apototic and antiproliferative effects are observed...
May 4, 2017: Oncology Research
https://www.readbyqxmd.com/read/28470146/microrna-520b-functions-as-a-tumor-suppressor-in-colorectal-cancer-by-inhibiting-dcun1d1
#19
Jing Xiao, Guang Li, Jingyu Zhou, Shalong Wang, Dongcai Liu, Guoshun Shu, Jianping Zhou, Feng Ren
MicroRNAs (miRs), a class of small non-coding RNAs, are important regulators for gene expression through directly binding to the 3'untranslated region (UTR) of their target mRNA. Recently, downregulation of miR-520b has been observed in several common human cancers. However, the exact role of miR-520b in colorectal cancer (CRC) has not previously been studied. In this study, our data showed that miR-520b was significantly downregulated in CRC and cell lines, when compared with adjacent normal tissues and normal intestinal epithelial cell line, respectively...
May 4, 2017: Oncology Research
https://www.readbyqxmd.com/read/28470145/mir-6838-promotes-growth-and-invasion-in-bladder-cancer-via-suppression-of-rb
#20
Yong-Hao Nan, Yao Wang, Peng-Hao Sun, Yuping Han, Li Fan, Kai-Chen Wang, Wei-Hua Wang
Here, the role of miR-6838, the exact function of which has not been reported, in the proliferation and invasion of human bladder cancer cells was explored. Our data showed that miR-6838 was sharply up-regulated in the bladder tissues from bladder cancer patients and 4 human bladder cancer cell lines, compared with the healthy volunteers and SU-HUC-1 human normal bladder epithelial cells. Then, different concentrations of miR-6838 mimics and miR-6838 antagomirs were respectively transfected into both T24 bladder cancer cell line...
May 4, 2017: Oncology Research
journal
journal
31034
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"