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Oncology Research

Yue Kui Jian, Huan Ye Zhu, Xing Lin Wu, Bo Li
Osteosarcomas, especially those with metastatic or unresectable disease, have limited treatment options. The antitumoreffects of pharmacologic inhibitors of angiogenesis in osteosarcomas are hampered in patients by the rapid development of tumor resistance, notably through increased invasiveness and accelerated metastasis. Here, we demonstrated that thrombospondin 1 (TSP1) is a potent inhibitor of osteosarcoma cells MG-63 growth and metastasis. Moreover, we demonstrate up-regulation of TSP-1 facilitated expression of vasculostatin in MG-63 cells...
March 14, 2018: Oncology Research
Teng Liu, Juan Xu, Hong Li Yan, Feng Chun Cheng, Xi Jie Liu
Luteolin, which was discovered in plant foods, has out range of therapeutic actions. In order to examine the potentialeffects of luteolin in ovarian teratocarcinoma, the human ovarian teratocarcinoma cell line PA-1 was used as in vitro and in vivo model. It was confirmed that the luteolin could inhibit the proliferation and colony formation of PA-1 cells in vitro. The flow cytometry results suggested that the luteolin could induce the apoptosis of PA-1 cells and in a dose-dependent manner. Immunofluorescence and PCR results showed the expanded expression of apoptosis was related to Bcl-2 and Bax proteins, which was also heightened in luteolin treated cells than control groups...
March 14, 2018: Oncology Research
Jinhua Dai, Jianbo Ma, Bixia Yu, Zhankun Zhu, Yanqin Hu
Glioma is the most common primary adult brain tumor. Mounting researches have illustrated the function of long non-coding RNAs (lncRNAs) in glioma progress, but almost no studies reported the role of TCL1 Upstream Neural Differentiation-Associated RNA (TUNAR) in glioma cells. This study aimed to investigate the function of TUNAR in glioma. GL15 cell line was used in this study. The interactions between TUNAR and miR-200a, or miR-200a and Rac1 were determined by co-transfection experiment. TUNAR overexpression significantly inhibited glioma malignancy by decreasing cell viability, migration, invasion and promoting cell apoptosis...
March 14, 2018: Oncology Research
Qing Yan, Ying Tian, Furong Hao
Cervical cancer has the second highest incidence rate among cancers in females, accounting for a majority of cancer-related deaths globally. However, the mechanism of cervical cancer pathogenesis is still unclear. UCA1 is considered an oncogene that can transcribe into a long noncoding RNA (lncRNA). This study aimed to determine the function of UCA1 in cervical cancer. A series of experiments involving BrdU, MTS, scratch-adhesion test, and cell invasion assays were conducted to determine the cellular capabilities of proliferation, viability, migration, and invasion, respectively...
March 9, 2018: Oncology Research
Ni Kou, Sha Liu, Xiaojie Li, Wuwei Li, Weijian Zhong, Lin Gui, Songling Chai, Xiang Ren, Risu Na, Tao Zeng, Huiying Liu
The long noncoding RNA (lncRNA) H19 has been described to participate in various tumors metastasis. Nevertheless, whether H19 promotes or impedestongue squamous cell carcinoma (TSCC) cells migration and invasion remains controversial. Here, we found that the expression of H19 was elevated in TSCC tissues compared with adjacent normal tissues. Moreover, we demonstrated that the expression of H19 was higher in metastasized tumors compared with un-metastasized tumors. Consistently, TSCC cells express higher levels of H19 than human squanous cells...
March 9, 2018: Oncology Research
Cong Ye, Yubo Hu, Junrong Wang
A large number of microRNAs (miRNAs) are aberrantly expressed in cervical cancer and play crucial roles in the onset and progression of cervical cancer by acting as either oncogene or tumor suppressor. Therefore, investigation on the expression, biological roles and underlying mechanisms of miRNAs in cervical cancer might provide valuable therapeutic targets in the treatment for patients with this disease. In this study, miRNA377 (miR-377) was downregulated in cervical cancer tissues and cell lines. Decreased miR-377 expression was strongly correlated with the International Federation of Gynecology and Obstetrics (FIGO) stage, lymph node metastasis and distant metastasis in patients with cervical cancer...
March 9, 2018: Oncology Research
Bo Xia, Lei Wang, Li Feng, Baofang Tian, Yuanjie Tan, Baoyin Du
Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. This study aimed to explore the effects of long non-coding RNA CAT104 and microRNA-381 (miR-381) on osteosarcoma cell proliferation, migration, invasion and apoptosis, as well as the underlying potential mechanism. We found that CAT104 was highly expressed in osteosarcoma MG-63 and OS-732 cells. Knockdown of CAT104 significantly inhibited OS-732 cell proliferation, migration and invasion, but promoted cell apoptosis. CAT104 regulated the expression of miR-381 and miR-381 participated in the effects of CAT104 on OS-732 cells...
March 9, 2018: Oncology Research
Yang Zhang, Min Zhu, Yuanbo Sun, Wenyuan Li, Ying Wang, Weiguang Yu
Long noncoding RNA cancer susceptibility candidate 2 (CASC2) has been identified to regulate the initiation and progression of multiple tumorous diseases. However, it was rarely reported in breast cancer. In present study, lncRNA CASC2 was found to be significantly down-regulated in breast cancer tissues and cell lines. We got this point with the quantitative real time-PCR. Furthermore, gain-of-function assays demonstrated that overexpression of lncRNA CASC2 significantly repressed proliferation and metastasis while caused cell cycle arrest and much more early apoptosis of breast cancer...
March 9, 2018: Oncology Research
Xin Chen, Mingzhe Li, Hongwei Zhou, Li Zhang
MicroRNA-132 (miR-132) has been proven to be a tumor suppressor in several types of tumors. However, the expression andthe role of miR-132 in human thyroid cancer are still poorly understood. The aim of the present study was to examine the potential roles and molecular mechanism of miR-132 in thyroid cancer. We found that miR-132 expression levels were significantly downregulated in thyroid cancer tissues and cell lines. Function assays showed that overexpression of miR-132 in TPC1 inhibited cell proliferation, migration and invasion...
March 9, 2018: Oncology Research
Xiaoying Han, Jing Yang, Dong Li, Zewei Guo
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated mortality worldwide. While, the mechanisms of HCC progression are not well understood. Recent studies demonstrated the potential contribution of uric acid transporter SLC2A9 to tumor suppression. However, the roles and underlying mechanisms are still unknown. We aim to study the roles and mechanisms of SLC2A9 in HCC. The present study showed that SLC2A9 expression was decreased in human HCC tissues and cell lines. In addition, Overexpression of SLC2A9 inhibited HCC cell proliferation...
March 9, 2018: Oncology Research
Xiaohui Shen, Xia Gao, Hui Li, Yajun Gu, Junguo Wang
Laryngeal carcinoma is a kind of head and neck carcinoma with high incidence and mortality. Chemotherapy treatments ofhuman laryngeal carcinoma may fail due to the development of chemo-resistance. Tissue inhibitor of metalloproteinases 3 (TIMP3) has been shown to be implicated in a number of pathological processes typical for cancer. The present study aims to investigate the involvement of TIMP-3 in chemo-resistance of laryngeal carcinoma. We showed that TIMP3 expression was significantly decreased in chemo-resistant laryngeal carcinoma tissues compared with chemo-sensitivity tissues...
March 9, 2018: Oncology Research
Genglong Zhu, Xialei Liu, Yonghui Su, Fangen Kong, Xiaopeng Hong, Zhidong Lin
Liver cancer is one of the most common malignancies in the world with a leading cause of cancer-related mortality. Accumulating evidences have highlighted the critical role of long noncoding RNAs (lncRNAs) in various cancers. The present study aimed to explore the role of lncRNA urothelial carcinoma associated 1 (UCA1) in cell growth and migration in MHCC97 cells and its underlying mechanism. Firstly, we assessed the expression of UCA1 in MHCC97 and other three cell lines by qRT-PCR. Then, the expression of UCA1, miR-301a and CXCR4 in MHCC97 cells were altered by transient transfection...
March 9, 2018: Oncology Research
Yuanshan Yao, Yinjie Zhou, Zhenhua Yang, Hongbo Huang, Haibo Shen
The purpose of this study was to determine the effects of resection coupled with standard chemotherapy on survival prognosis of patients with early-stage small cell lung carcinoma (SCLC). Patients (n=110) with mediastinal lymph node-negative SCLC were enrolled in this study. The baseline clinical data of patients with surgery was retrospectively reviewed. Overall and progression-free survival were measured by Kaplan-Meier and log-rank test analyses. Ninety-eight patients received mediastinoscopy biopsy and pulmonary lobectomy or sublobar resection, and 67 patients underwent adjuvant chemotherapy after pulmonary lobectomy...
March 9, 2018: Oncology Research
Jinfeng Qu, Lei Zhang, Lanyu Li, Yujie Su
This study was aimed to investigate the tumor suppressive role of miR-148b in regulating endoplasmic reticulum metalloprotease 1 (ERMP1) expression and oxidative stress response in endometrial cancer cells. Human endometrial cancer RL95-2 cells were used and transfected with miR-148b mimic, miR-148b inhibitor, and their scrambled negative control. Thereafter, the transfection efficiency was determined by qRT-PCR and cell viability was assessed by MTT assay. The luciferase reporter assay, Western blot, and qRT-PCR were conducted to determine the target gene of miR-148b...
March 9, 2018: Oncology Research
Zhenjun Liu, Pei Zhao, Yuping Han, Song Lu
Long non-coding RNAs (lncRNA) have been reported to play important roles in tumorigenesis. In present study, we demonstrated long noncoding RNA (lncRNA) FEZF1 antisense RNA1 (FEZF1-AS1) is markedly upregulated in human lung adenocarcinoma (LAD) tissues, cell lines and associated with poor prognosis. Loss-of-function revealed that deletion of FEZF1-AS1 expression significantly inhibited the LAD cells proliferation, invasion and migration. Further studies revealed that downregulation of FEZF1-AS1 reduced mRNA and protein expression of its sense-cognate gene FEZF1 (forebrain embryonic zinc finger protein 1) in LAD cells, and vice versa...
March 6, 2018: Oncology Research
Shihui Liu, Xiuxiu Li, Sujing Zhuang
MiR-30c has been acknowledged as a tumor suppressor in various human cancers, such as ovarian cancer, gastric cancer and prostate cancer. However, the role of miR-30c in glioblastoma (GBM) needs to be investigated. In our study, we found that the expression of miR-30c was significantly downregulated in GBM tissues and cell lines. We found that overexpression of miR-30c inhibited cellular proliferation of GBM cells in vitro and in vivo . More GBM cells were arrested in G0 phase after miR-30c overexpression. Moreover, we showed that miR-30c overexpression suppressed the migration and invasion of GBM cells...
March 1, 2018: Oncology Research
Jia Yu, Qiyu Fang, Shuyan Meng
Non-small cell lung cancer (NSCLC) represents the leading cause of cancer-related mortality worldwide. More and more reports have identified important roles for long noncoding RNAs (lncRNAs) in cancer development. ENST457720 expression was upregulated in lung adenocarcinoma in a microarray-based lncRNA screen. We determined the expression levels of ENST457720 in NSCLC tissues with quantitative real-time PCR and then studied their clinical significance. We explored the biological significance of ENST457720 with gain- and loss-of-function analyses in vitro and in vivo...
March 1, 2018: Oncology Research
Xingxiang Liu, Lin Cui, Dong Hua
We aimed to investigate the significant role of long non-coding RNA X Inactive Specific Transcript (XIST) in regulatingtumor metastasis in colorectal cancer (CRC), as well as its possible mechanism. Expression of lncRNA XIST in CRC tissues and CRC cells was detected. CRC cells were transfected with pc-XIST, blank control si-XIST or si-control, and then the effects of lncRNA XIST on CRC cell migration and invasion were investigated, along with the interaction between lncRNA XIST and miR-137. LncRNA XIST was upregulated in CRC tissues...
March 1, 2018: Oncology Research
Liang Wu, Yuefeng Li, Jingye Li, Deliang Ma
A large number of microRNAs (miRNAs) have been previously demonstrated to be dysregulated in breast cancer (BC), and alterations in miRNA expression may affect the initiation and progression of BC. This study showed that miR-664 expression was obviously reduced in BC tissues and cell lines. Resumption expression of miR-664 attenuated the proliferation and invasion of BC cells. The molecular mechanism underlying the inhibitory effects of BC cell proliferation and invasion by miR-664 was also studied. Insulin receptor substrate 1 (IRS1) was identified as a novel and direct target of miR-664...
March 1, 2018: Oncology Research
Lihua Jiang, Wenchuan Yang, Weishi Bian, Hailin Yang, Xia Wu, Yuhua Li, Wen Feng, Xuejian Liu
The dysregulation of microRNAs (miRNAs) plays an important function in the onset and progression of gastric cancer (GC). In addition, aberrantly expressed miRNAs affect the chemosensitivity of GC cells to chemotherapeutic drugs. Hence, miRNA-based targeted therapy might be applied to treat patients with GC exhibiting chemotherapeutic resistance. In this study, miRNA-623 (miR-623) expression was downregulated in GC tissues and cell lines. Functional analysis showed that the restored miR-623 expression could inhibit the proliferation of GC cells and enhance their chemosensitivity to 5-FU via the cell apoptosis pathway...
March 1, 2018: Oncology Research
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