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Oncology Research

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https://www.readbyqxmd.com/read/30180922/1-25-oh-2d3-attenuates-il-1%C3%AE-induced-epithelial-to-mesenchymal-transition-through-inhibiting-the-expression-of-lnctcf7
#1
Tengyu Li, Jing Zhu, Shuai Zuo, Shanwen Chen, Ju Ma, Yongchen Ma, Shihao Guo, Pengyuan Wang, Yucun Liu
The activated form of vitamin D3, 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), regulates numerous cellular processes, including inhibition of cancer progression. IL-1β has been reported to facilitate cancer development, especially by inducing an epithelial-to-mesenchymal transition (EMT) in several malignant tumors. However, the underlying mechanism of 1,25(OH)2D3 and IL-1β in colorectal cancer (CRC) still remains largely unknown. To fill in this knowledge gap, we measured cell proliferation and invasion by CCK-8 and transwell assays after stimulation with 1,25(OH)2D3 and IL-1β...
September 4, 2018: Oncology Research
https://www.readbyqxmd.com/read/30131091/clinical-characteristics-and-molecular-patterns-of-ret-rearranged-lung-cancer-in-chinese-patients
#2
Kai Zhang, Huajun Chen, Ye Wang, Lin Yang, Chengzhi Zhou, Weiqiang Yin, Guangsuo Wang, Xinru Mao, Jianxing Xiang, Bing Li, Tengfei Zhang, Shihong Fei
RET rearrangement has been proven as an oncogenic driver in patients with lung cancer. However, the prevalence, clinical characteristics, molecular features and therapeutic options in RET-rearranged patients remain unclear, especially in Chinese lung cancers. We retrospectively collected 6125 Chinese lung cancer patients who have been profiled using next-generation sequencing (NGS). The clinical demographics and molecular features of RET rearrangement-positive patients were analyzed. RET rearrangements were identified in 84 patients with proportion of 1...
August 21, 2018: Oncology Research
https://www.readbyqxmd.com/read/30131090/astragaloside-iv-inhibits-the-progression-of-non-small-cell-lung-cancer-through-akt-gsk-3%C3%AE-%C3%AE-catenin-pathway
#3
Liwei Jia, Dongying Lv, Shuang Zhang, Zhenyue Wang, Bo Zhou
Astragaloside IV (AS-IV) is an active ingredient in Astragalus membranaceus, and involved in various biological processes, such as regulating the immune system, and counteracting inflammation and malignancy. The aim of this study was to explore the effect of AS-IV on non-small cell lung cancer (NSCLC) cells. A cell counting kit (CCK)-8 assay and flow cytometry were performed to investigate cell survival and cell death, and Western blotting was performed to assess protein expression. We found that AS-IV inhibited the migration and proliferation of NSCLC cells, and caused a noticeable increase in cell death...
August 21, 2018: Oncology Research
https://www.readbyqxmd.com/read/30131089/microrna-152-acts-as-a-tumor-suppressor-microrna-by-inhibiting-kr%C3%A3-ppel-like-factor-5-in-human-cervical-cancer
#4
Haiyan Zhang, Yanxia Lu, Surong Wang, Xiugui Sheng, Shiqian Zhang
Aberrant expression of microRNA-152 (miR-152) is frequently observed in human cancers including ovarian cancer, breast cancer, prostate cancer, and gastric cancer. However, its expression and functional role in cervical cancer (CC) is poorly understood. Also, the association between miR-152 and Krüppel-like factor 5 (KLF5) expression in CC remains unclear. In this study, analyzing the expression of miR-152 by quantitative real-time PCR (qRT-PCR) revealed it was sharply reduced in CC tissues and cell lines...
August 21, 2018: Oncology Research
https://www.readbyqxmd.com/read/29471895/etv6-flt3-fusion-is-a-novel-client-protein-of-hsp90
#5
Bui Thi Kim Ly, Hoang Thanh Chi
FMS-like tyrosine kinase-3 fragments from exon 14 to the end without any mutations or deletions have been reported to fuse to ETV6 (TEL) in a few cases of myeloid/lymphoid neoplasms with eosinophilia carrying a translocation t(12;13)(p13;q12). This fusion protein confers constitutive activation on the FLT3 fragment and induces factor-independent growth in transfected Ba/F3 cells, indicating that it is an oncoprotein. However, the mechanism controlling the stability of this oncoprotein is unknown. In this study, we focus on finding factors controlling the stability of ETV6/FLT3...
September 14, 2018: Oncology Research
https://www.readbyqxmd.com/read/29463348/long-noncoding-rna-fgfr3-as1-promotes-hepatocellular-carcinoma-carcinogenesis-via-modulating-the-pi3k-akt-pathway
#6
Juhua Zhuang, Saifei He, Guoyu Wang, Guangdong Wang, Jing Ni, Suiliang Zhang, Ying Ye, Wei Xia
Hepatocellular carcinoma (HCC) as one of the most refractory cancers leads to high mortality worldwide. Long noncoding RNAs have been widely acknowledged as important biomarkers and therapeutic targets in HCC. In this study, we investigated the effects of long noncoding RNA FGFR3-AS1 on tumor growth and metastasis in HCC. First, we found that the expression of FGFR3-AS1 was upregulated about threefold in HCC samples and cell lines. We knocked down FGFR3-AS1 in Huh7 and Hep3B cells and found that FGFR3-AS1 knockdown significantly inhibited cell proliferation but induced apoptosis...
September 14, 2018: Oncology Research
https://www.readbyqxmd.com/read/29444745/microrna-598-inhibits-cell-proliferation-and-invasion-of-glioblastoma-by-directly-targeting-metastasis-associated-in-colon-cancer-1-macc1
#7
Ning Wang, Yang Zhang, Huaxin Liang
The dysregulation of microRNA (miRNA) expression is closely related with tumorigenesis and tumor development in glioblastoma (GBM). In this study, we found that miRNA-598 (miR-598) expression was significantly downregulated in GBM tissues and cell lines. Restoring miR-598 expression inhibited cell proliferation and invasion in GBM. Moreover, we validated that metastasis associated in colon cancer-1 (MACC1) is a novel target of miR-598 in GBM. Restoring MACC1 expression reversed the inhibitory effects of miR-598 overexpression on GBM cells...
September 14, 2018: Oncology Research
https://www.readbyqxmd.com/read/29426375/triptolide-inhibits-proliferation-and-migration-of-human-neuroblastoma-sh-sy5y-cells-by-upregulating-microrna-181a
#8
Jian Jiang, Xuewen Song, Jing Yang, Ke Lei, Yongan Ni, Fei Zhou, Lirong Sun
Neuroblastoma is the primary cause of cancer-related death for children 1 to 5 years of age. New therapeutic strategies and medicines are urgently needed. This study aimed to investigate the effects of triptolide (TPL), the major active component purified from Tripterygium wilfordii Hook F, on neuroblastoma SH-SY5Y cell proliferation, migration, and apoptosis, as well as underlying potential mechanisms. We found that TPL inhibited SH-SY5Y cell viability, proliferation, and migration, but induced cell apoptosis...
September 14, 2018: Oncology Research
https://www.readbyqxmd.com/read/29422113/puerarin-inhibits-proliferation-and-induces-apoptosis-by-upregulation-of-mir-16-in-bladder-cancer-cell-line-t24
#9
Xiaoyun Liu, Shuguang Li, Yanyan Li, Bo Cheng, Bo Tan, Gang Wang
Bladder cancer (BC) is a common disease of the urinary system. Puerarin is a flavonoid extracted from Pueraria lobata. However, the role of puerarin in BC remains unclear. Hence, this study aimed to investigate the effect of puerarin on BC cells. Cell viability, proliferation, and apoptosis were measured by CCK-8, BrdU assay, and flow cytometry analysis, respectively. The expressions of miR-16, apoptosis-related factors, and the main factors of the NF-κB pathway were analyzed by qRT-PCR and Western blot. In this study, we found that cell viability and proliferation were significantly reduced, cell apoptosis was enhanced, and the mRNA level of miR-16 was upregulated in puerarin-treated T24 cells...
September 14, 2018: Oncology Research
https://www.readbyqxmd.com/read/29402343/microrna-204-inhibits-the-growth-and-motility-of-colorectal-cancer-cells-by-downregulation-of-cxcl8
#10
Feng Shuai, Bo Wang, Shuxiao Dong
Among all of the miRNAs, miR-204 has gained considerable attention in the field of cancer research. This study aimed to reveal the detailed functions and the underlying mechanism of miR-204 in colorectal cancer (CRC) cells. The expressions of miR-204 in CRC tumor tissues and cell lines were monitored. Expressions of miR-204 and CXCL8 in Caco-2 and HT-29 cells were altered by transfection, and then cell viability, apoptosis, migration, invasion, EMT-related protein expression, and PI3K/AKT/mTOR pathway protein expression were assessed...
September 14, 2018: Oncology Research
https://www.readbyqxmd.com/read/29391086/b7-homolog-4-promotes-epithelial-mesenchymal-transition-and-invasion-of-bladder-cancer-cells-via-activation-of-nuclear-factor-%C3%AE%C2%BAb
#11
Haoran Wu, Xugang Wang, Naixin Mo, Liang Zhang, Xiaoliang Yuan, Zhong Lü
B7-homolog 4 (B7-H4), a member of the B7 family of costimulatory molecules, has been reported to be upregulated in urothelial cell carcinoma. This study was conducted to explore the biological role of B7-H4 in the aggressiveness of bladder cancer and the associated molecular mechanism. We found that the mRNA and protein levels of B7-H4 were significantly greater in bladder cancer cell lines than in SV-HUC-1 (normal human urothelial cells). Overexpression of B7-H4 significantly promoted bladder cancer cell migration and invasion, whereas knockdown of B7-H4 exerted an opposite effect...
September 14, 2018: Oncology Research
https://www.readbyqxmd.com/read/29386089/long-noncoding-rna-gas5-promotes-proliferation-migration-and-invasion-by-regulation-of-mir-301a-in-esophageal-cancer
#12
Wei Li, Weidong Zhao, Zhaohui Lu, Wen Zhang, Xuan Yang
Long noncoding RNA (lncRNA) growth arrest-specific transcript 5 (GAS5) has been revealed to be associated with the progression of various cancers. However, the biological roles of GAS5 in esophageal cancer (EC) remain unclear. We aimed to thoroughly explore the functions of GAS5 in EC. The results showed that GAS5 expression was increased in EC cells (ECA109, TE-1, TE-3, and EC9706) compared to SHEE cells. Knockdown of GAS5 decreased cell viability, migration, and invasion and induced apoptosis in EC9706 cells...
September 14, 2018: Oncology Research
https://www.readbyqxmd.com/read/29386087/mir-135a-confers-resistance-to-gefitinib-in-non-small-cell-lung-cancer-cells-by-upregulation-of-rac1
#13
Tingting Zhang, Ning Wang
The EGFR tyrosine kinase inhibitor gefitinib is used in therapy for non-small cell lung cancer (NSCLC). However, the therapeutic efficacy of gefitinib is known to be impeded by mutations of EGFR. The aim of the present study was to reveal the role of miR-135a in gefitinib resistance of NSCLC cells. Human NSCLC cell lines, NCI-H1650 and NCI-H1975, were transfected with miR-135a mimic/inhibitor or miR-135a inhibitor plus pEX-RAC1 (a RAC1-expressing vector). The effects of miR-135a and RAC1 expression on cell viability, apoptosis, migration, and invasion were then detected...
September 14, 2018: Oncology Research
https://www.readbyqxmd.com/read/29321083/microrna-338-3p-suppresses-proliferation-of-human-liver-cancer-cells-by-targeting-sphk2
#14
Geqiong Xiao, Qiong Wang, Bo Li, Xiaohui Wu, Hui Liao, Yili Ren, Ning Ai
Recent studies have revealed abnormal expression of miRNAs in various tumors. Although microRNA-338-3p (miR-338-3p) plays an important role in many types of tumors, its influence on liver cancer (LC) is unknown. In this study, we found that expression of miR-338-3p was decreased in LC cells and tissues. Colony formation and cell proliferation were suppressed by enhanced expression of miR-338-3p in LC cells. Moreover, miR-338-3p targeted sphingosine kinase 2 (SphK2). Silencing of SphK2 had an identical influence as overexpression of miR-338-3p in LC cells...
September 14, 2018: Oncology Research
https://www.readbyqxmd.com/read/29301592/transglutaminase-2-promotes-migration-and-invasion-of-lung-cancer-cells
#15
Hung-Tsung Lee, Cheng-Hsieh Huang, Wuan-Chun Chen, Chi-Shan Tsai, Yu-Lin Chao, Szu-Han Liu, Jun-Hong Chen, Yi-Ying Wu, Yi-Ju Lee
Lung cancer is the leading cause of cancer deaths worldwide. Given that the major threat of cancer is metastasis, delineation of the molecular mechanism underlying it would help devise therapeutic strategies. Transglutaminase 2 (TG2), belonging to the transglutaminase superfamily, is a versatile protein with enzymatic and nonenzymatic functions. It mainly localizes inside the cell, but also appears extracellularly. Recent findings have demonstrated the involvement of TG2 in cancer development. Here we examine the role of TG2 in metastasis of lung cancer using a lung cancer cell line CL1-0, which exhibits low invasiveness, and its invasive subline CL1-5...
September 14, 2018: Oncology Research
https://www.readbyqxmd.com/read/28915933/mir-1290-contributes-to-colorectal-cancer-cell-proliferation-by-targeting-inpp4b
#16
Qingzhu Ma, Yan Wang, Hualing Zhang, Fengqiang Wang
Colorectal cancer (CRC) is one of the most common oncological conditions worldwide, to date. MicroRNA-1290 (miR-1290) has been demonstrated to regulate its progression. We studied the role of miR-1290 in CRC progression. The gene was upregulated in CRC tissues and cells. Its overexpression promoted CRC cell proliferation analyzed by MTT assay, colony formation assay, and soft agar growth assay. In addition, miR-1290 knockdown inhibited CRC cell proliferation. We also found that miR-1290 overexpression reduced the p27 level and increased cyclin D1 at both the mRNA and protein levels, whereas miR-1290 knockdown increased p27 and reduced cyclin D1, confirming miR-1290 promoted CRC cell proliferation...
September 14, 2018: Oncology Research
https://www.readbyqxmd.com/read/28899457/swainsonine-inhibits-invasion-and-the-emt-process-in-esophageal-carcinoma-cells-by-targeting-twist1
#17
Junxun Ma, Lijie Wang, Jinyu Li, Guoqing Zhang, Haitao Tao, Xiaoyan Li, Danyang Sun, Yi Hu
Esophageal cancer is a common gastrointestinal cancer, with a very high mortality rate in patients with metastasis. Swainsonine, a cytotoxic fungal alkaloid, has been shown to inhibit cell growth in esophageal cancer. In the present study, we explored the effects of swainsonine on cell invasion and metastasis in esophageal cancer cells. Human esophageal carcinoma cells were treated with different doses of swainsonine, and then cell viability, invasion, and apoptosis were measured. The mRNA and protein expressions of Twist1, apoptosis- and EMT-related factors, and PI3K/AKT pathway factors were detected by qRT-PCR and Western blot...
September 14, 2018: Oncology Research
https://www.readbyqxmd.com/read/28893347/mir-203-suppresses-bladder-cancer-cell-growth-and-targets-twist1
#18
Jie Shen, Jianhua Zhang, Minhui Xiao, Junfeng Yang, Ningnan Zhang
miR-203 is an epigenetically silenced tumor-suppressive microRNA in tumors. This study was designed to investigate the effects of miR-203 on the proliferation, migration, invasion, and apoptosis of bladder cancer (BCa) cells. The expression levels of miR-203 in BCa tissues, normal adjacent tissues, and BCa cell lines were detected. BCa cells were transfected with miR-203 mimic and inhibitor to investigate the effect of miR-203 on cell functions and the epithelial-mesenchymal transition (EMT). Cotransfection with miR-203 inhibitor and shRNA of the predicted target gene Twist1 (si-Twist1) was performed to investigate the target relationship of miR-203 and Twist1...
September 14, 2018: Oncology Research
https://www.readbyqxmd.com/read/28800784/upregulation-of-microrna-4262-targets-kaiso-zbtb33-to-inhibit-the-proliferation-and-emt-of-cervical-cancer-cells
#19
Jing Feng
More and more studies have reported that dysregulation of microRNAs (miRNAs) leads to the proliferation and EMT of multiple cancers. Recently, several reports have demonstrated that dysregulation of miR-4262 occurs in numerous cancers. However, its role and precise mechanism in human cervical cancer (CC) have not been well clarified. Hence, this study aimed to explore the biological roles and precise mechanisms of miR-4262 in CC cell lines. The level of miR-4262 was found to be significantly decreased in CC tissues and cell lines...
September 14, 2018: Oncology Research
https://www.readbyqxmd.com/read/28600863/silencing-of-lncrna-ccdc26-restrains-the-growth-and-migration-of-glioma-cells-in-vitro-and-in-vivo-via-targeting-mir-203
#20
Shilei Wang, Yuzuo Hui, Xiaoming Li, Qingbin Jia
Gliomas are the most common primary brain tumors with high mortality. The treatment for gliomas is largely limited due to its uncomprehending pathological mechanism. Here we aimed to investigate the effect of long noncoding RNA (lncRNA) coiled-coil domain-containing 26 (CCDC26) in glioma progression. In our study, the expression of CCDC26 was found upregulated in glioma tissues and cell lines compared with normal tissues and cell lines. Further exploration detected decreased cell proliferation and increased cell apoptosis in U-251 and M059J cells transfected with CCDC26-siRNA...
September 14, 2018: Oncology Research
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