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Oncology Research

Camila Ramalho Bonturi, Helena Motaln, Mariana Cristina Cabral Silva, Bruno Ramos Salu, Marlon Vilela de Brito, Luciana de Andrade Luz Costa, Heron Fernandes Vieira Torquato, Natáia Neto Dos Santos Nunes, Edgar Julian Paredes-Gamero, Tamara Lah Turnšek, Maria Luiza Vilela Oliva
Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor with an overall patient survival of about 16 months. Thus, natural compounds with anti-cancer properties are gaining attention as possible alternatives for GBM treatment. Studies in various cancer models have shown the anti-cancer effects of the Enterolobium contortisiliquum Trypsin Inhibitor (EcTI). Here, we investigated the outcomes of EcTI on U87 cells, mesenchymal stem cells (MSC), and their direct cocultures (U87/MSC). MSC are present in tumor stroma and represent a potential drug delivery vehicle as the result of their tumor tropism...
July 11, 2017: Oncology Research
Dina Polosukhina, Harold Love, Harold Moses, Ethan Lee, Roy Zent, Peter Clark
Wilms tumor (WT) is the most common renal malignancy of childhood and the fourth most common pediatric solid malignancyin the United States. While the mechanisms underlying the WT biology are complex, these tumors most often demonstrate activation of the canonical Wnt/ß-catenin pathway. We and others have shown that constitutive activation of ß-catenin restricted to the renal epithelium is sufficient to induce primitive renal epithelial tumors which resemble human WT. Here we demonstrate that pharmacologic inhibition of ß-catenin gene transcription with pyrvinium inhibits tumor growth and metastatic progression in a murine model of WT...
July 10, 2017: Oncology Research
Shu Chen, Lianhua Jin, Shu Nie, Lizhi Han, Na Lu, Yan Zhou
Accumulating evidence indicates that microRNA-205 (miR-205) is involved in tumor initiation, development, and metastasis in various cancers. However, its functions in neuroblastoma(NB) remain largely unclear. Here, we found that miR-205 was significantly downregulated in human NB tissue samples and cell lines. miR-205 expression was lower in poorly differentiated NB tissues and those of advanced International Neuroblastoma Staging System stage. In addition, restoration of miR-205 in NB cells suppressed proliferation, migration, and invasion, and induced cell apoptosis in vitro, as well as impaired tumor growth in vivo...
June 26, 2017: Oncology Research
Shidan Liu, Jiaxi Luan, Yan Ding
This study aimed to investigate the role of miR-144-3p in pancreatic cancer (PC) carcinogenesis and to explore the mechanism of its function in PC. miR-144-3p was down-regulated in PC tissues and cells. miR-144-3p overexpression significantly inhibited PC cell proliferation, migration and invasion. FosB proto-oncogene, AP-1 transcription factor subunit (FOSB) was a target gene of miR-144-3p. miR-144-3p could repress PC cell proliferation, migration and invasion by inhibiting the expression of FOSB. In conclusion, miR-144-3p plays an important role in PC cell proliferation, migration and invasion by targeting FOSB...
June 24, 2017: Oncology Research
Meng Yang, Xu Zhai, Tingting Ge, Chang Yang, Ge Lou
Expression of miR-181a-5p associates with the proliferation and progression of cancer cells via its targets. This studywas designed to investigate the effect of miR-181a-5p and its target inositol polyphosphate-5-phosphatase A (INPP5A) on progression of cervical cancers. Upregulation of miR-181a-5p was revealed in cervical cancer cell lines HeLa and SiHa in comparison with End1/E6E7 (p < 0.001). The inhibition and upregulation of miR-181a-5p in cervical cancer cell lines significantly reduced or increased cell proliferation and invasion capacity, accompanied with enhanced or reduced apoptosis (p < 0...
June 23, 2017: Oncology Research
Xiaoyan Wang, Yongguang Xu, Xinlei Chen, Jianmin Xiao
This study aimed to investigate the effect of dexmedetomidine (DEX) on osteosarcoma (OS) cell line MG63 and to explorethe possible relationship between DEX and miR-520-3p in OS. The results showed that DEX could up-regulate miR-520-3p which directly targeted AKT1. Additionally, miR-520-3p also inhibited MG63 cell proliferation and migration, promoted apoptosis, and suppressed protein expressions of AKT, p-AKT, p-mTOR and p-ERK1/2. DEX can inhibit OS cell proliferation and migration, and promote apoptosis by up-regulating the expression level of miR-520a-3p...
June 23, 2017: Oncology Research
Jingdong Li, Youmei Zi, Wanling Wang, Yan Li
Maternally expressed gene 3 (MEG3), a long non-coding RNA, has been reported to be associated with the pathogenesis ofmultiple malignancies. However, little is known regarding the role of MEG3 in leukemia. In this study, we found that the expression of MEG3 was decreased in leukemia patients and cell lines, and has potential to be considered as a biomarker for leukemia. In addition, overexpression of MEG3 inhibited cell proliferation and invasion in vitro and in vivo. Moreover, a potential bonding site between miR-184 and MEG3 was predicted, and low expression of miR-184 was found in leukemia patients and cell lines...
June 22, 2017: Oncology Research
Xiu-Xin Wang, Hong-Tao Jia, Hua Yang, Mao-Hua Luo, Tao Sun
Prostate cancer (PC) is one of the most common malignancies of men. Glutathione S-transferase P1 (GSTP1) has been suggested to play a protective role in the prostate. The proto-oncogene MYC has been extensively proved to be a key regulator of tumor transformation from early stage to malignant. Our study aims to investigate the mechanism of GSTP1 in the biological behavior of PC. Compared with normal prostate tissues, the expression of GSTP1 was decreased in PC tissues. Conversely, the level of MYC was increased in PC tissues compared with normal tissues...
June 19, 2017: Oncology Research
Anne Riemann, Antje Güttler, Verena Haupt, Henri Wichmann, Sarah Reime, Matthias Bache, Dirk Vordermark, Oliver Thews
Carbonic anhydrase IX has emerged as a promising target for cancer therapy. It is highly up-regulated in hypoxic regions and mediates pH regulation critical for tumor cell survival as well as extracellular acidification of the tumor microenvironment which promotes tumor aggressiveness via various mechanisms, such as augmenting metastatic potential. Therefore, the aim of this study was to analyze the complex interdependency between CA IX and the tumor microenvironment in prostate tumor cells in concern of potential therapeutic implications...
June 19, 2017: Oncology Research
Adilijiang Maimaitiming, Ailijiang Wusiman, Abulajiang Aimudula, Tuhetiaji Tudahong, Dilimulati Aisimutula
The aim of the present study was to investigate the roles of microRNA-152 (miR-152) in breast cancer initiation and progression. Expression levels of miR-152 were detected in human breast cancer tissues and in a panel of human breast cancer cell lines. In this study, analyzing miR-152 expression by qRT-PCR showed that it was remarkably down-regulated in breast cancer tissues and cell lines. Enforced miR-152 expression suppressed cell proliferation, migration and invasion of breast cancer. Moreover, ROCK1 was identified as a direct and functional target gene of miR-152 in breast cancer using luciferase assay...
June 15, 2017: Oncology Research
Yanli Wang, Jia Li, Chunling Xu, Xiaomeng Zhang
Increasing evidence indicates that the dysregulation of microRNAs is associated with the development and progression ofvarious cancers. MicroRNA-139-5p (miR-139-5p) has been reported to have tumor-suppressive role in many types of cancers. But the role of miR-139-5p in ovarian cancer (OC) is poorly understood. The purpose of the present study was to explore the expression of miR-139-5p and its function in OC. The results showed that miR-139-5p expression was markedly downregulated in OC tissues and cell lines...
June 14, 2017: Oncology Research
Dandan Li, Changjun He, Junfeng Wang, Yanbo Wang, Jianlong Bu, Xianglong Kong, Dawei Sun
Many studied have shown that down-regulated level of miR-138 is in a variety of cancers including non-small cell lung cancer (NSCLC). However, the precise mechanisms of miR-138 in NSCLC have not been well clarified. In this study, we investigated the biological functions and molecular mechanisms of miR-138 in NSCLC cell lines, discussing whether it could be a therapeutic biomarker of NSCLC in the future. In our study, we found that miR-138 is down-regulated in NSCLC tissues and cell lines. Moreover, the low level of miR-138 was associated with increased expression of SOX4 in NSCLC tissues and cell lines...
June 13, 2017: Oncology Research
Yan Cui, Lei Yi, Ming-Ming Zhang, Yu Zhou, Zhi-Gang Tan, Tao Huang, Yu-Gang Jiang
Long non-coding RNAs (lncRNAs) are proved as important regulators in many diseases, including multiple cancers. HOXA11antisense RNA (HOXA11-AS) is a novel identified lncRNA associated with cancer progression. However, the role of HOXA11-AS in glioma remains poorly understood and needs to be elucidated. The purpose of this study is to investigate the role and regulating mechanism of HOXA11-AS on gliomagenesis. Expression of HOXA11-AS was significantly up-regulated in glioma tissue and cell lines compared to the adjacent normal tissue and cells...
June 12, 2017: Oncology Research
Zhili Cao, Xiang Zheng, Lei Cao, Naixin Liang
MicroRNAs (miR) play key roles in cancers, yet the potential molecular mechanisms of miR-539 on esophageal squamous cell carcinoma (ESCC) are not well understood. Screened by informatics method, Twist-related protein 1 (TWIST1) was hypothesized to be a possible target gene of miR-539. Since the melanoma associated antigen (MAGE) A4 is reported to be up-regulated by TWIST1, this study aimed to examine the biological functions and mechanism involving TWIST1 and MAGE4 of miR-539 in ESCC. MiR-539 mimics or scrambled miRs were transfected into human ESCC TE3 cells to interfere the expression of miR-539...
June 12, 2017: Oncology Research
Shilei Wang, Yuzuo Hui, Xiaoming Li, Qingbin Jia
Gliomas are the most common primary brain tumors with high mortality. The treatment for gliomas is largely limited dueto the uncomprehending pathological mechanism. Here we aimed to investigate the effect of long non-coding RNA (lncRNA) coiled-coil domain-containing 26 (CCDC26) in gliomas progression. In our study, the expression of CCDC26 was found up-regulated in gliomas tissues and cell lines compared with normal tissues and cell lines. Further exploration detected decreased cell proliferation and increased cell apoptosis in U-251 and M059J cells transfected with CCDC26-siRNA...
June 9, 2017: Oncology Research
Akinori Sato, Takako Asano, Kazuki Okubo, Makoto Isono, Tomohiko Asano
The human immunodeficiency virus (HIV) protease inhibitor nelfinavir acts against malignancies by inducing endoplasmicreticulum (ER) stress. The HIV protease inhibitor ritonavir, on the other hand, not only induces ER stress but also inhibits P-glycoprotein's pump activity and thereby enhances the effects of its substrate drugs. We therefore postulated that ritonavir in combination with nelfinavir would kill bladder cancer cells effectively by inducing ER stress cooperatively and also enhancing nelfinavir's effect...
May 26, 2017: Oncology Research
Xiaowen Chen, Jianli Chen
This study intended to investigate the effects of miR-3188 on breast cancer and to reveal the possible molecular mechanisms. miR-3188 was up-regulated and TUSC5 was down-regulated in breast cancer tissues and MCF-7 cells compared to normal tissue and MCF-10 cells. After MCF-7 cells were transfected with miR-3188 inhibitor, cell proliferation and migration were inhibited, while apoptosis was promoted. Luciferase reporter assay suggested that TUSC5 was a target gene of miR-3188. In addition, miR-3188 overexpression increased the p-p38 expression, while miR-3188 suppression decreased the p-p38 expression significantly...
May 26, 2017: Oncology Research
Yong Zhang, Qingfeng Dai, Fanying Zeng, Haichun Liu
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long noncoding RNA (lncRNA) that contributes to the initiation and development of many solid tumors, including osteosarcoma (OS). In this study, we showed that MALAT1 was increased in human OS tissues and cell lines. MALAT1 knockdown suppressed OS cell growth and metastasis, induced OS cell apoptosis and delayed tumor growth in an OS xenograft model. We also detected downregulation of microRNA-509 (miR-509), a suppressor of OS growth, in OS tissues and cell lines...
May 26, 2017: Oncology Research
Kun Zhou, Liping Wang, Ruirui Cheng, Xia Liu, Shengya Mao, Yan Yan
Drug resistance is the major obstacle for the successful therapy of lung adenocarcinoma. It was suggested that ß-elemene, a major isoform of elemene, could reverse the drug resistance in lung cancer cells. However, the underlying mechanisms remains poorly known. Here, we aimed to investigate whether elemene is involved in the cisplatin (DDP)-resistance of lung adenocarcinoma cells and further explore the underlying mechanism. The results showed that human lung adenocarcinoma cell line SPC-A-1 and its DDP-resistant strain SPC-A-1/DDP had a similar sensitivity to elemene treatment...
May 23, 2017: Oncology Research
Jun-Jun Zhang, Dan-Dan Wang, Chen-Xiang Du, Yan Wang
Cervical cancer is a common malignancy of female reproductive system. Long non-coding RNA (lncRNA) has been reported tomodulate tumor progression in multiple cancers. The lncRNA antisense non-coding RNA in the INK4 locus (ANRIL) has been testified as oncogenic molecular in series tumors, however, the function and underlying mechanism involved in cervical cancer oncogenesis is still unclear. In present study, RT-PCR showed that ANRIL expression was significantly up-regulated in cervical cancer tumors and cell lines...
May 22, 2017: Oncology Research
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