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Oncology Research

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https://www.readbyqxmd.com/read/28160462/knockdown-of-trim44-inhibits-the-proliferation-and-invasion-in-prostate-cancer-cells
#1
Yuying Tan, Hanxin Yao, Jinghai Hu, Lingyun Liu
Tripartite motif 44 (TRIM44), a member of the TRIM protein family, has been shown to play a role in tumor development and progression. However, the potential involvement of TRIM44 in prostate cancer has not been fully explored. Therefore, in the present study, we analyzed the expression of TRIM44 in prostate cancer and assessed the role of TRIM44 in the progression of prostate cancer. Our results showed that the expression of TRIM44 was significantly up-regulated in human prostate cancer cell lines. In addition, knockdown of TRIM44 significantly inhibited the proliferation, migration and invasion of prostate cancer cells in vitro, as well as attenuated the tumor growth in vivo...
February 3, 2017: Oncology Research
https://www.readbyqxmd.com/read/28160461/foxo1-malat1-mir-26a-5p-feedback-loop-mediates-proliferation-and-migration-in-osteosarcoma-cells
#2
Juntao Wang, Guodong Sun
MiR-26a has been found to be downregulated in osteosarcoma (OS) compared with normal control tissues and has been shownto be able to suppress the malignant behaviors of OS cells. The underlying mechanism, nevertheless, remains unknown. Here, in our study, the long non-coding RNA MALAT1, confirmed to be significantly up-regulated in OS, was firstly shown to be capable of promoting proliferation and migration by directly suppressing miR-26a-5p in OS cells. In addition, we've identified Forkhead Box O 1 (FOXO1) was a transcriptional factor of MALAT1 that can negatively regulate MALAT1...
February 3, 2017: Oncology Research
https://www.readbyqxmd.com/read/28117030/three-combined-treatment-a-novel-hdac-inhibitor-obp-801-ym753-5-fluorouracil-and-paclitaxel-induces-g2-phase-arrest-through-the-p38-pathway-in-human-ovarian-cancer-cells
#3
Makoto Akiyama, Yoshihiro Sowa, Tomoyuki Taniguchi, Motoki Watanabe, Shingo Yogosawa, Jo Kitawaki, Toshiyuki Sakai
Ovarian cancer is the most lethal disease among gynecological malignancies. More effective therapy is required to counter the high recurrence rates and chemotherapy resistance. We investigated the efficacy and molecular mechanisms of three-combined treatment, a novel histone deacetylase (HDAC) inhibitor OBP-801/YM753, 5-fluorouracil (5-FU) and paclitaxel (PTX), in human ovarian cancer SKOV-3 and OVCAR-3 cells. The inhibition of cell growth was stronger with the three-combined treatment than with each single agent and with two-combined treatment...
January 23, 2017: Oncology Research
https://www.readbyqxmd.com/read/28117029/microrna-148a-acts-as-a-tumor-suppressor-in-osteosarcoma-via-targeting-rho-associated-coiled-coil-kinase
#4
HaiYan Yang, ZhiGang Peng, ZhenZhen Da, Xin Li, YeXiao Cheng, BinBin Tan, Xin Xiang, HaiPing Zheng, Yan Li, LanHua Chen, Ning Mo, XueXin Yan, Xiaolin Li, XiaoHua Hu
MicroRNAs (miRs) have been demonstrated to be involved in the development and progression of osteosarcoma (OS), but themolecular mechanism still remains to be fully investigated. The present study aimed to investigate the function of miR-148a in osteosarcoma, as well as the underlying mechanism. Our data showed that miR-148a was significantly downregulated in OS tissues compared to their matched adjacent normal tissues, and also in OS cell lines compared to normal human osteoblast cells. Low expression of miR-148a was significantly associated with tumor progression and poor prognosis of OS patients...
January 23, 2017: Oncology Research
https://www.readbyqxmd.com/read/28117028/lncrna-gas5-inhibits-tumorigenesis-and-enhances-radiosensitivity-by-suppressing-mir-135b-expression-in-non-small-cell-lung-cancer
#5
Yingbo Xue, Tingting Ni, Ying Jiang, Yong Li
GAS5 has been demonstrated to be correlated with clinicopathological characteristics and serve as a tumor suppressor innon small cell lung cancer (NSCLC). However, the underlying mechanism of competing endogenous RNA (ceRNA) regulatory network involving GAS5 in NSCLC remains to be elucidated. In this study, qRT-PCR results showed that GAS5 was down-regulated and miR-135b was up-regulated in NSCLC tissues and cells. The expressions of GAS5 and miR-135b changed inversely in response to irradiation. Gain of function experiments revealed that GAS5 overexpresion and miR-135b downregulation significantly suppressed tumorigenesis by repressing cell proliferation, invasion and enhanced radiosensitivity of NSCLC cells by reducing colony formation rates...
January 23, 2017: Oncology Research
https://www.readbyqxmd.com/read/28117027/microrna-133b-inhibits-proliferation-cellular-migration-and-invasion-via-targeting-lasp1-in-hepatocarcinoma-cells
#6
Hui Li, Zhigang Xiang, Yan Liu, Bin Xu, Jianzhou Tang
MicroRNAs (miRs), a class of small non-coding RNAs, are key gene regulators through inducing translational repression or degradation of their target genes. However, the regulatory mechanism of miR-133b underlying hepatocellular carcinoma (HCC) growth and metastasis remains largely unclear. Here we found that miR-133b was significantly downregulated in HCC tissues and cell lines. Moreover, low miR-133b levels were significantly associated with the malignant progression of HCC. LASP1, upregulated in HCC tissues and cell lines, was then identified as a novel target of miR-133b in HCC HepG2 and Hep3B cells...
January 23, 2017: Oncology Research
https://www.readbyqxmd.com/read/28109089/betulinic-acid-inhibits-cell-proliferation-in-human-oral-squamous-cell-carcinoma-via-modulating-ros-regulated-p53-signaling
#7
Huan Shen, Li Liu, Yongjin Yang, Wenxing Xun, Kewen Wei, Guang Zeng
Oral squamous cell carcinoma (OSCC) is a common cancer of the head and neck. Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid. The present study was designed to explore the effects of BA on OSCC KB cell proliferation <em>in vitro</em> and implanted tumor growth <em>in vivo</em> and to examine the possible molecular mechanisms. The results showed that BA dose-dependently inhibited KB cell proliferation and decreased implanted tumor volume. In addition, BA significantly promoted mitochondrial apoptosis, as reflected by increase of TUNEL-positive cells and activities of caspase 3 and 9, increase of Bax expression and decrease of Bcl-2 expression and mitochondrial oxygen consumption rate...
January 20, 2017: Oncology Research
https://www.readbyqxmd.com/read/28109087/cd103-cell-growth-factor-flt3l-enhances-the-efficacy-of-immune-checkpoint-blockades-in-murine-glioblastoma-model
#8
Xiaolin Miao, Yiqi Chen, Ke Hao, Meiqin Zheng, Bingyu Chen, Kaiqiang Li, Ying Wang, Wei Zhang, Yu Zhang, Xiaozhou Mou, Shanshan Jiang, Zhen Wang
Glioblastoma is a lethal disease featured with a high proliferation of tumor cells, excessive angiogenesis, and heavydrug resistance. The overall survival of glioblastoma patients was dismal even with intensive standard care. Recent advantages in immune checkpoint blockades are changing the treatment of cancers. However, the efficacy of immune checkpoint blockades in glioblastoma were unclear. Here, we investigated the roles of CD103<sup>+</sup> cells in regulating the effects of immune checkpoint blockades in glioblastoma mouse models...
January 20, 2017: Oncology Research
https://www.readbyqxmd.com/read/28109086/grade-dependent-expression-of-nima-related-kinase-2-in-glioma-and-its-cellular-upregulatory-activity-on-proliferation-and-invasion
#9
Li Tian, Peng Cheng, Huaiyu Sun, Yulin Wang, Lei Zhang, Zongze Guo
Glioma is one of the most common tumors in central nervous system. The median life expectancy for glioma patients is only 13-15 months. NIMA-related expressed kinase 2 (NEK2) is a kind of serine-threonine kinases and involves in carcinogenesis and progression of cancer, however, the specific roles in the glioma remains unknown. We found the high expression of NEK2 was positively correlated with deteriorated severity of glioma. Therefore, we sought to investigate the effects of NEK2 on U87 and U251 cells. To explore the expression of NEK2 and alteration of signaling pathway factors, qRT-PCR and Western blot analysis were performed...
January 20, 2017: Oncology Research
https://www.readbyqxmd.com/read/28109085/silencing-of-interferon-induced-transmembrane-protein-1-ifitm1-inhibits-proliferation-migration-and-invasion-in-lung-cancer-cells
#10
Bing Jin, Hua Jin, Jing Wang
Interferon-induced transmembrane protein 1 (IFITM1), a 17-kDa membrane protein, is largely known as a player in many cellular functions. Recently, there have been studies showing overexpression of IFITM1 in cancers and a positive correlation of IFITM1 overexpression with tumor progression. However, it is poorly understood what role IFITM1 plays in lung cancer. In this study, we presented evidence that IFITM1 was highly expressed in lung cancer tissues and cell lines. IFITM1 silencing inhibited lung cancer cell proliferation, migration and invasion <em>in vitro</em>...
January 20, 2017: Oncology Research
https://www.readbyqxmd.com/read/28109084/mir-5195-3p-inhibits-proliferation-and-invasion-of-human-bladder-cancer-cells-by-directly-targeting-oncogene-klf5
#11
Zhangjie Jiang, Yida Zhang, Runfu Cao, Li Li, Kezhao Zhong, Qingsheng Chen, Jianjun Xiao
MiRNAs played key roles in carcinogenesis of many cancers including bladder cancer. In current study, the role of miR-5195-3p, a quite recently discovered and poorly studied miRNA, in the proliferation and invasion of human bladder cancer cells was investigated. Our data displayed that, compared with the healthy volunteers (control) and SU-HUC-1 human normal bladder epithelial cells, miR-5195-3p was sharply down-regulated in the bladder cancer patients and 5 human bladder cancer cell lines. Then, the oligo miR-5195-3p mimic or miR-5195-3p antagomir was respectively transfected into both T24 and BIU-87 bladder cancer cell lines...
January 20, 2017: Oncology Research
https://www.readbyqxmd.com/read/28109082/microrna-133a-inhibits-proliferation-of-gastric-cancer-cells-by-downregulating-erbb2-expression
#12
Chang Li, Xiaoping Li, Shuohui Gao, Chang Li, Lianjun Ma
Gastric cancer is the fourth most common cancer and the second leading cause of cancer-related deaths worldwide. It hasalready been established that miR-133a is involved in gastric cancer. In this study, we aimed to investigate the molecular mechanisms by which miR-133a inhibits the proliferation of gastric cancer cells. We analyzed the proliferative capacity of human gastric cancer cells SNU-1, using MTT assay. Cell apoptosis was determined using flow cytometry. The expression levels of ERBB2, p-ERK1/2 and p-AKT in SNU-1 cells were determined using Western blot analysis...
January 20, 2017: Oncology Research
https://www.readbyqxmd.com/read/28109080/microrna-21-inhibits-the-apoptosis-of-osteosarcoma-cell-line-saos-2-via-targeting-caspase-8
#13
Bin Xu, Hehuan Xia, Junming Cao, Zhihong Wang, Yipeng Yang, Yongsheng Lin
Currently, multiple microRNAs (miRNAs) have been found play vital roles in the pathogenesis of osteosarcoma. This studywas aimed to investigate the role of miR-21 in osteosarcoma. The level of miR-21 in 20 pairs of osteosarcoma and correspondingly adjacent tissues were monitored by qPCR. Human osteosarcoma cells line SAOS-2 was transfected with either miR-21 mimic or miR-21 inhibitor, and then cell viability, survival and apoptosis were respectively measured by MTT, colony formation assay, and flow cytometry...
January 20, 2017: Oncology Research
https://www.readbyqxmd.com/read/28109079/silencing-of-ribosomal-protein-l34-rpl34-inhibits-the-proliferation-and-invasion-of-esophageal-cancer-cells
#14
Huijie Fan, Jing Li, Yongxu Jia, Jingjing Wu, Long Yuan, Mingjun Li, Jiangqi Wei, Benling Xu
Ribosomal protein L34 (RPL34) belongs to the L34E family of ribosomal proteins and contains a zinc finger motif. Aberrant expression of RPL34 has been reported in several human malignancies. However, the precise role and potential underlying mechanisms of RPL34 in human esophageal cancer remain largely unknown. Thus, the objective of this study was to investigate the role of RPL34 in esophageal cancer progression. Our results showed that the expression of RPL34 at both mRNA and protein levels was frequently up-regulated in esophageal cancer cell lines...
January 20, 2017: Oncology Research
https://www.readbyqxmd.com/read/28109078/3-phosphoinositide-dependent-protein-kinase-1-pdk-1-promotes-migration-and-invasion-in-gastric-cancer-cells-through-activating-the-nf-%C3%AE%C2%BAb-pathway
#15
Ning Wu, Changyu He, Bohui Zhu, Jinling Jiang, Yiwen Chen, Tao Ma
Gastric cancer (GC) is one of the most common cancers and the second leading cause of cancer deaths in the world. Manyfactors were reported involving the progression and development of GC. In this study, we aimed to investigate the correlation of 3-phosphoinositide dependent protein kinase 1 (PDK-1) with cell viability, cell migration, and cell invasion of GC. The expression of PDK-1 was measured in different GC cell lines. Thereafter, the expression of PDK-1 was interfered by small hairpin RNA (shRNA) and then incubated with or without the inhibitor of NF-κB pyrrolidine dithiocarbamate (PDTC)...
January 20, 2017: Oncology Research
https://www.readbyqxmd.com/read/28109077/simultaneous-but-not-consecutive-combination-with-folinate-salts-potentiates-5-fluorouracil-antitumor-activity-in-vitro-and-in-vivo
#16
Antonello Di Paolo, Paola Orlandi, Teresa Di Desidero, Romano Danesi, Guido Bocci
The combination of folinate salts to 5-fluoruracil (5-FU)-based schedules is an established clinical routine in the landscape of the colorectal cancer treatment. The aim of this study was to investigate the pharmacological differences between the sequential administration of folinate salts (1 h before, as in clinical routine) followed by 5-FU and the simultaneous administration of both drugs. Proliferation and apoptotic assays were performed on human colon cancer cells exposed to 5-FU, calcium (CaLV) or disodium (NaLV) levofolinate or their simultaneous and sequential combination for 24 and 72h...
January 20, 2017: Oncology Research
https://www.readbyqxmd.com/read/28109076/microrna-409-3p-represses-glioma-cell-invasion-and-proliferation-by-targeting-high-mobility-group-nucleosome-binding-domain-5
#17
Yidong Cao, Liang Zhang, Minghao Wei, Xue Jiang, Dong Jia
Emerging evidence has suggested that aberrantly expressed microRNAs (miRNAs) are associated with glioma development andprogression. The aberrant expression of miR-409-3p has been reported in several human cancers. However, little is known about the function of miR-409-3p in gliomas. The aim of this study was to investigate the specific role and molecular mechanism of miR-409-3p in gliomas. In the present study, we found that miR-409-3p was downregulated in glioma tissue and cell lines. Overexpression of miR-409-3p inhibited glioma cell invasion and proliferation, whereas suppression of miR-409-3p promoted glioma cell invasion and proliferation...
January 20, 2017: Oncology Research
https://www.readbyqxmd.com/read/28109075/knockdown-of-tacc3-inhibits-the-proliferation-and-invasion-of-human-renal-cell-carcinoma-cells
#18
Feng Guo, Yaquan Liu
Transforming acidic coiled-coil protein 3 (TACC3) is a member of the TACC family and plays an important role in regulating cell mitosis, transcription and tumorigenesis. However, the expression pattern and roles of TACC3 in renal cell carcinoma (RCC) remain unclear. The aim of this study was to investigate the role of TACC3 in RCC. We demonstrated overexpression of TACC3 in human RCC cell lines at both RNA and protein levels. Moreover, knockdown of TACC3 repressed RCC cell proliferation, migration and invasion <em>in vitro</em>...
January 20, 2017: Oncology Research
https://www.readbyqxmd.com/read/28109073/cyclin-dependent-kinase-inhibitor-3-promotes-cancer-cell-proliferation-and-tumorigenesis-in-nasopharyngeal-carcinoma-by-targeting-p27
#19
Huimin Wang, Hexin Chen, Hang Zhou, Wenfa Yu, Zhenmin Lu
Nasopharyngeal carcinoma (NPC) is a common head and neck malignancy with high invasion which arises from the nasopharynx epithelium. Cyclin-dependent kinase inhibitor 3 (CDKN3) belongs to the dual-specificity protein phosphatase family which plays a key role in regulating cell division. Abnormal expression of CDKN3 has been found in numerous types of cancer. In the current study, we explored the possible role of CDKN3 in cell proliferation, invasion ability and radiosensitivity in NPC cells. We reported that CDKN3 was upregulated and P27 was downregulated in NPC tissues and associated with worse patient prognosis...
January 20, 2017: Oncology Research
https://www.readbyqxmd.com/read/28059053/long-noncoding-rna-gas5-suppresses-tumorigenesis-by-inhibiting-mir-23a-5-expression-in-non-small-cell-lung-cancer
#20
Yongcheng Mei, Jinchun Si, Yun Wang, Zhuangshi Huang, Haiwen Zhu, Shijun Feng, Xuezhi Wu, Liwen Wu
Previous studies reported that elevated expression of long noncoding RNA GAS5 led to NSCLC cell growth arrest and a promotion of apoptosis both <em>in vitro</em> and <em>in vivo</em>. However, its underlying molecular mechanism in NSCLC is still unclear. In the present study, we noted that GAS5 was down-regulated in NSCLC tissues and cells and was negatively correlated with miR-23a expression. Luciferase reporter assay and qRT-PCR analysis demonstrated that GAS5 directly interacted with miR-23a and reversely regulate its expression...
January 5, 2017: Oncology Research
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