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Oncology Research

Jian Ding, Fuqing Wang, Tiangang Xiang, Meng Qiao
The aberrant expression of long noncoding RNAs (lncRNAs) is implicated in cancer development and progression. This study aimed to investigate the expression and clinical significance of lncRNA NONHSAT129183 in papillary thyroid cancer (PTC), and explore its roles in PTC cell proliferation, migration, and invasion. Our results demonstrate that lncRNA NONHSAT129183 is upregulated in human PTC tissues when compared with that in adjacent noncancerous thyroid tissue. Moreover, its expression is correlated with tumor size, lymph node metastasis, and TNM stage in PTC patients...
January 10, 2018: Oncology Research
Atsushi Fujiwara, Masamichi Yoshida, Hajime Fujimoto, Hiroki Nakahara, Kentaro Ito, Kota Nishihama, Taro Yasuma, Osamu Hataji, Osamu Taguchi, Corina N D'Alessandro-Gabazza, Esteban C Gabazza, Tetsu Kobayashi
Tyrosine kinase inhibitors (TKIs) are very effective against non-small-cell lung cancer caused by epidermal growth factor receptor (EGFR) mutation. Before the approval of osimertinib in March 2016, there were only three available EGFR TKIs (gefitinib, erlotinib and afatinib) for the therapy of non-small-cell lung cancer in Japan. Osimertinib can be indicated only against T790M (+) lung cancer as a second-line therapy. However, whether gefitinib, erlotinib or afatinib is most appropriate as a first-line therapy is still a controversial issue...
January 10, 2018: Oncology Research
Bo Hu, Xunbo Jin, Jianbo Wang
Prostate cancer (PCa) is the second most commonly diagnosed malignancy and the fifth leading cause of cancer-related deaths in males worldwide. MicroRNAs (miRNAs) may serve as important regulators in PCa occurrence and development. Therefore, understanding the expression and functions of PCa-related miRNAs may be beneficial for the identification of novel therapeutic methods for patients with PCa. In this study, miRNA-212 (miR-212) was evidently downregulated in PCa tissues and several PCa cell lines. Functional assays showed that the resumption expression of miR-212 attenuated cell proliferation and invasion and increased the apoptosis of PCa...
January 10, 2018: Oncology Research
Wei Lei, Wang Kang, Yang Nan, Zhang Lei, Li Zhongdong, Li Demin, Sun Lei, Huang Hairong
This study was aimed to investigate the function and mechanism of microRNA-200c (miR-200c) in the progression of non-small cell lung cancer (NSCLC). A total of 76 patients diagnosed as NSCLC were enrolled in this study. Then, the expression level of miR-200c in NSCLC tissues and cell lines was investigated using the quantitative realtime polymerase chain reaction (RT-qPCR) method. We found the expression of miR200c was significantly reduced in NSCLC tissues and cell lines compared with in normal lung tissues and human bronchial epithelial cell line...
January 10, 2018: Oncology Research
Fei Li, Bin Liu, Xiaolan Zhou, Quan Xu
DNA damage response induced by ionizing radiation (IR) is an important event that involved in the sensitivity and efficiency of radiotherapy in human medulloblastoma. RNF8 is a E3 ubiquitin ligase and has key roles in the process of DNA damage and repair. Our study aimed to evaluate the effect of RNF8 in the DNA damage repair induced by IR exposure in medulloblastoma cells. We found that the levels of RNF8 were significantly up-regulated by γ-ray irradiation in a dose-dependent manner in medulloblastoma cells, and colocalized with γ-H2AX, a sensitive marker of DNA double strand break induced by γ-ray radiation...
January 10, 2018: Oncology Research
Peng Guo, Guohui Zhang, Jialin Meng, Qian He, Zhihui Li, Yawei Guan
Bladder cancer (BC) is one of the leading causes of cancer-related death in the word. Long non-coding RNA (lncRNA) taurine-upregulated gene 1 (TUG1) plays an important role in the development and progression of numerous cancers, including BC. However, the exact role of TUG1 in modulating BC progression is still poorly known. In this study, we found that TUG1 was upregulated and microRNA-29c (miR-29c) was downregulated in BC tissues and cell lines. Overexpression of TUG1 promoted the cell proliferation of T24 and EJ cells, whereas TUG1 knockdown had the opposite effect...
January 10, 2018: Oncology Research
Xuejian Liu, Xia Wu, Yanming Wang, Yuhua Li, Xiangli Chen, Wenchuan Yang, Lihua Jiang
Excessive expression of Cluster of Differentiation 47 (CD47) is common in various malignancies. The aim of this study was to investigate whether CD47 promotes human glioblastoma invasion and its underlying mechanism of CD47 in promoting glioblastoma invasion. In this study we found that CD47 expression was stronger in glioblastoma patients and cells in comparison with normal controls. CD47 downregulation modulated by siRNA suppressed invasion in vitro. However, excessive CD47 expression modulated by transfection exerted opposite influence...
January 10, 2018: Oncology Research
Saifei He, Guangdong Wang, Jing Ni, Juhua Zhuang, Suiliang Zhuang, Guoyu Wang, Ying Ye, Wei Xia
Dysregulated microRNAs (miRNAs) expression is involved in the occurrence and development of colorectal cancer (CRC) through the regulation of various important physiological events. Hence, miRNAs may be used as effective targets for CRC treatment; however, this hypothesis warrants further investigation. MiRNA-511 (miR511) plays vital roles in the progression of different tumour types. However, the expression, exact role and the mechanisms underlying the regulation of colorectal carcinogenesis and progression by miR-511 remain poorly understood...
January 10, 2018: Oncology Research
Lixia Jiang, Shaohua Shi, Qiaofa Shi, Huijuan Zhang, Yu Xia, Tianyu Zhong
HIF-2α knockdown inhibits proliferation, arrests the cell cycle, and promotes apoptosis and autophagy under hypoxic conditions in cervical cancer. However, the upstream regulatory mechanism of HIF-2α expression is unclear. MicroRNAs (miRNAs) degrade target mRNA by binding to the 3' untranslated region of mRNA. In this study, we investigated the role of miRNA in the regulation of HIF-2α expression in cervical cancer under hypoxic conditions. miRNAs regulating HIF-2α expression were predicted using TargetScan and miRanda, and were determined in cervical cancer under hypoxic conditions by qRT-PCR...
January 10, 2018: Oncology Research
Mao Guoping, Liu Ran, Qin Yanru
Recent studies have suggested that the dysregulation of microRNAs (miRNAs) plays a critical role in the progression ofhuman cancers including gastric cancer (GC). miR-143 had been reported to function as tumor suppressor in GC. However, the exact molecular mechanism of how miR-143 participated in GC progression remains to be well studied. In this present study, we revealed that the expression of miR-143 was significantly downregulated in human GC tissues and cell lines compared with normal tissues and normal gastric epithelium cell line...
January 10, 2018: Oncology Research
Geqiong Xiao, Qiong Wang, Bo Li, Xiaohui Wu, Hui Liao, Yili Ren, Ning Ai
It has been recently revealed that there is abnormal expression of miRNA in various tumors. Despite the fact that microRNA-338-3p (miR-338-3p) can play an important role in many kinds of tumors, whether it has an influence on liver cancer (LC) is undetermined. In this study, we found that the expression of miR-338-3p was decreased in LC cells as well as tissues. Clone formation and cell proliferation are suppressed by enhanced expression of miR-338-3p in LC cells. Moreover, we found that miR-338-3p targeted Sphingosine Kinase 2 (SphK2)...
January 10, 2018: Oncology Research
Xingquan Zhai, Wei Xu
This study was aimed to explore the biological functions of long non-coding RNA activated by transforming growth factor-beta (lncRNA-ATB) in bladder cancer cells. For the expressions of lncRNA-ATB, miR-126 and KRAS, T24 cells were transfected with their specific vectors/shRNA or mimic/inhibitor. Then, cell viability, migration, invasion and apoptosis, as well as the protein levels of apoptosis-related factors and PI3K/AKT and mTOR signal pathways were measured, respectively. Further, the relationships of lncRNA-ATB and miR-126 or miR-126 and KRAS were analyzed by dual-luciferase report assay...
January 10, 2018: Oncology Research
Juan Gu, Chang-Fu Cui, Li Yang, Ling Wang, Xue-Hua Jiang
Colon cancer (CC) is the third most common cancer worldwide. Emodin is a kind of anthraquinone active substance which has the ability to affect tumor progression. Our study aims to explore the effects and the relevant mechanism of Emodin on the invasion and migration of CC in vitro and in vivo. In our study, we found that Emodin inhibited the invasion and migration ability of RKO cells and decreased the expression of Matrix metalloproteinase-7 (MMP-7), Matrix metalloproteinase-9 (MMP-9), and Vascular endothelial growth factor (VEGF) in a dose dependent manner...
January 4, 2018: Oncology Research
Hung-Tsung Lee, Cheng-Hsieh Huang, Wuan-Chun Chen, Chi-Shan Tsai, Yu-Lin Chao, Szu-Han Liu, Jun-Hong Chen, Yi-Ying Wu, Yi-Ju Lee
Lung cancer is the leading cause of cancer death worldwide. Given that the major threat of cancer is metastasis, delineation of the molecular mechanism underlying it would help devise therapeutic strategies. Transglutaminase 2 (TG2), belonging to the transglutaminase superfamily, is a versatile protein with enzymatic and non-enzymatic functions. It mainly localizes inside the cell, but also appears extracellularly. Recent findings have demonstrated the involvement of TG2 in cancer development. Here we examine the role of TG2 in metastasis of lung cancer using a lung cancer cell line CL1-0 which exhibits low invasiveness, and its invasive subline CL1-5...
January 4, 2018: Oncology Research
Liqing Zhang, Jianjiang Xu, Gaodi Yang, Heng Li, Xiuxia Guo
Recent studies have demonstrated that miR-202 is associated with several types of cancer; however, the expression and function of miR-202 have not been investigated in bladder cancer. Here, we analyzed the expression of miR-202 in bladder cancer tissue and adjacent non-cancerous tissues. The effect of miR-202 on proliferation, migration and invasion was evaluated by in-vitro assays. The target gene of miR-202 was assessed by luciferase reporter assay. In this study, miR-202 was found to be significantly downregulated in bladder cancer cell lines and tissues, and was highly correlated with the T classification, N classification, grade, and recurrence...
January 3, 2018: Oncology Research
Peizhen Yang, Dechong Sun, Fei Jiang
Ailanthone (AIL) is a quassinoid isolated from the traditional Chinese medicinal herb Ailanthus altissima. The anti-tumor activities of AIL have been reported in several cancers. The purpose of the present study was to explore the effect of AIL on vestibular schwannomas (VSs). Various concentration of AIL (0~1 μM) was used to treat human primary VS cells, and then cell viability, proliferation, apoptosis, and autophagy were assessed, respectively. Expression of miR-21 in VS cells was altered by miRNA transfection...
January 3, 2018: Oncology Research
Xianguang Feng, Wenhuan Yao, Zengzhen Zhang, Fangshui Yuan, Li Liang, Jingqiang Zhou, Shuang Liu, Jiqing Song
Tbx3, a member of the T-box family of transcription factors, contribute directly to tumor formation, migration and invasion. However, the role of Tbx3 in the metastasis of HCC remains unclear. In the present study, Tbx3 expression was detected in HCC tissues and cells by Western blot, and then the expression of Tbx3 was regulated by siRNAs or lentivirus-mediated vectors. Here, we found that the Tbx3 protein expression increased in HCC tissues and cell lines. Tbx3 expression was positively associated with multiple tumor nodes, venous infiltration and advanced TNM tumor stage...
January 2, 2018: Oncology Research
Jianping Xu, Liguo Sun, Wei Sun, Jianhai Tian, Huaiyuan Guo
To investigate the effect of Kim-1 on 786-0 cells in vivo and in vitro, Several experiments such as quantitative real-time PCR, western blot, MTT, colony formation and flow cytometry were performed to evaluate biological behavior of 786-0 with Kim-1 siRNA. Furthermore, tumor xenograft model was performed on BALB/c nude mice to assess Kim-1 silencing. As results showed, lentivirus-mediated RNAi have an effectively silencing on Kim-1 in 786-0 cells. Kim-1 knockdown significantly inhibited the proliferation and colony formation ability of 786-0 cells (P<0...
January 2, 2018: Oncology Research
Yingying Wang, Yongjie Tian
miR-206 and bcl2-associated athanogene 3 (BAG3) have been suggested as important regulators in various cancer types. However, the biological role of miR-206 and BAG3 in cervical cancer (CC) remains unclear. Here, we investigated the expressions and mechanisms of miR-206 and BAG3 in cervical cancer using in vitro and in vivo assays. In the present study, miR-206 expression was expressed at a lower level in CC tissues and cells than adjacent normal tissues and NEEC cells. By contrast, BAG3 mRNA and protein were expressed at higher levels in CC tissues and cells...
January 2, 2018: Oncology Research
Haiyan Jia, Hong Wang, Yanfen Yao, Chunlei Wang, Pibao Li
MicroRNAs (miRNAs) play a vital role in regulating tumor progression. Dysregulated miR-136expression was linked to thedevelopment of various human cancers. In the present study, we investigated the expression and relationship of miR-136 and COX2in hepatocellular carcinoma (HCC) using relevant experiments, involving CCK-8, Transwell assay, and luciferase-reporter assay. We demonstrated that miR-136 expression is obviously decreased in HCC tissues and cells, and negatively correlated with the expression of COX2 mRNA...
January 2, 2018: Oncology Research
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