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Oncology Research

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https://www.readbyqxmd.com/read/28810936/lncrna-c2dat1-promotes-cell-proliferation-migration-and-invasion-by-targeting-mir-34a-5p-in-osteosarcoma-cells
#1
Daofu Jia, Yanping Niu, Dongling Li, Zhaorui Liu
Osteosarcoma is a highly aggressive malignant bone tumor with poor prognosis in cases. Evidence suggested that lncRNAsare deregulated in multiple cancers. In this study, we investigated the role of the lncRNA C2dat1 on the biological functions of osteosarcoma cells. The expressions of C2dat1, miR-34a-5p and Sirt1 in human osteosarcoma cells were altered by transfection with their specific vectors/shRNA, or mimic/inhibitor. Then, cell viability, migration, invasion and apoptosis were respectively assessed post-transfection...
August 15, 2017: Oncology Research
https://www.readbyqxmd.com/read/28810933/microrna-152-suppresses-human-osteosarcoma-cell-proliferation-and-invasion-by-targeting-e2f-transcription-factor-3
#2
Chao Ma, Jinfeng Han, Dong Dong, Nanya Wang
MicroRNA-152(miR-152) expression has been reported to be downregulated in osteosarcoma (OS). However, the role of miR-152 in OS is not well documented. In the present study, we aim to explore the function and underlying mechanism of miR-152 in OS. We found that miR-152 was underexpressed in OS tissues and cell lines. Decreased miR-152 was inversely correlated with lymph-node metastasis and advanced clinical stage. Overexpression of miR-152 significantly inhibited cell proliferation, colony formation, migration and invasion of OS cells...
August 15, 2017: Oncology Research
https://www.readbyqxmd.com/read/28810932/lncrna-neat1-promotes-growth-and-metastasis-of-cholangiocarcinoma-cells
#3
Cheng Zhang, Jing-Yi Li, Fu-Zhou Tian, Gang Zhao, Hai Hu, Yue-Feng Ma, Yu-Long Yang
Long non-coding RNAs (lncRNAs) are known to play important roles in cancers. However, little is known about lncRNAs incholangiocarcinoma (CCA), a cholangiocyte malignancy with poor prognosis. We investigated the role of Nuclear Paraspeckle Assembly Transcript 1 (NEAT1) lncRNA in promoting cholangiocarcinoma (CCA). qRT-PCR analysis of patient samples showed that NEAT1 expression was higher in CCA tumors than matched adjacent non-tumor tissue. NEAT1 levels were also higher in CCA cell lines than a normal biliary epithelium cell line (HIBEpic)...
August 15, 2017: Oncology Research
https://www.readbyqxmd.com/read/28800794/long-intergenic-noncoding-rna-319-linc00319-promotes-cell-proliferation-and-invasion-in-lung-cancer-cells-by-directly-downregulating-the-tumor-suppressor-mir-32
#4
Bo Zhou, Wenwen Yuan, Xinping Li
Long non-coding RNAs (lncRNAs) have been shown to play important regulatory roles in the pathogenesis and progression of multiple cancers. Here, we investigated the role of long intergenic non coding RNA 319 (linc00319) in the proliferation and invasion of lung cancer cells. We found that, compared with normal lung cell line HBE, linc00319 was increased in low metastatic lung cancer cell lines PAa and AgiY-83a, and further increased in high metastatic lung cancer cell lines A549 and Anip-973. Then, different concentrations of pcDNA-linc00319 expression vector and different concentrations of linc00319 siRNA were respectively transfected into A549 lung cancer cells...
August 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28800793/upregulation-of-hint2-inhibits-non-small-cell-lung-cancer-cell-invasion-via-cox-2-pge%C3%A2-mediated-activation-of-%C3%A3-catenin-signaling
#5
Jie Li, Siwen Chen, Bin Ni
Histidine triad nucleotide binding protein 2 (HINT2) belongs to a HIT superfamily. It is ubiquitous and can be detectedin all forms of life. Recently, this protein has been reported to function as a tumor suppressor in some kind of cancers. However, little is known about its precise role in non-small cell lung cancer (NSCLC). In the present study, we explored the effects of HINT2 on the invasive potential of NSCLC cells. Our results showed that the expression of HINT2 was reduced in NSCLC tissues and cell lines...
August 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28800792/microrna-125a-5p-inhibits-cell-proliferation-and-induces-apoptosis-in-hepatitis-b-virus-related-hepatocellular-carcinoma-by-downregulation-of-erbb3
#6
Guoyun Li, Wei Zhang, Li Gong, Xiaoping Huang
MicroRNAs, a class of endogenous non-coding RNAs, regulate gene expression at post-transcriptional level, thus taking part in multiple biological processed. Increasing miRNAs are found to be dysregulated in hepatocellular carcinoma (HCC) and are involved in liver tumorigenesis. In this study, miR-125a-5p was found to obviously downregulate much more in hepatitis B virus (HBV)-related HCC. To investigate the effects of miR-125a-5p, miR-125a-5p was overexpressed in HepG2.2.15 and HepG3X cells, respectively. The findings have indicated that overexpression of miR-125a-5p dramatically inhibited cell proliferation and induced cell apoptosis...
August 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28800791/microrna-154-inhibits-the-growth-and-invasion-of-gastric-cancer-cells-by-targeting-dixdc1-wnt-signaling
#7
Jifu Song, Zhibin Guan, Maojiang Li, Sha Sha, Chao Song, Zhiwei Gao, Yongli Zhao
MicroRNAs (miRNAs) have emerged as pivotal regulators of the development and progression of gastric cancer. Studies have shown that miR-154 is a novel cancer-associated miRNA involved in various cancers. However, the role of miR-154 in gastric cancer remains unknown. Here we aimed to investigate the biological function and the potential molecular mechanism of miR-154 in gastric cancer. We found that miR-154 was significantly downregulated in gastric cancer tissues and cell lines. The overexpression of miR-154 significantly repressed the growth and invasion of gastric cancer cells...
August 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28800790/mir-641-functions-as-a-tumor-suppressor-by-targeting-mdm2-in-human-lung-cancer
#8
Qinglong Kong, Nan Shu, Jun Li, Ning Xu
Lung cancer is the leading cause of deaths due to cancer. Studies suggest important role of microRNAs (miRNAs) in a variety of cancer, including lung cancer. In the present study, we evaluated the role of miR-641 in human lung cancer A549 cells. Quantitative RT-PCR and Western blot was used to measure the mRNA and protein expression, respectively. Cell viability and cell apoptosis were respectively measured by MTT assay and flow cytometry. Besides, luciferase activity assay was used to identify the target of miR-641...
August 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28800788/mir-204-regulates-cell-proliferation-and-invasion-by-targeting-ephb2-in-human-cervical-cancer
#9
Shanhong Duan, Ali Wu, Zhengyu Chen, Yarong Yang, Liying Liu, Qi Shu
MicroRNAs (miRNAs) are small non-coding RNAs that involved in human carcinogenesis and progression. miR-204 has been reported to be a tumor suppressor in several cancer types. However, the function and underlying molecular mechanism of miR-204 in cervical cancer (CC) are still unclear. In the present study, the expression level of miR-204 was measured using qRT-PCR method in 30 paired CC clinical samples and 6 CC cell lines. We found that the expression of miR-204 was significantly down-regulated in CC tissues and cell lines compared to normal cervical tissues and cell line...
August 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28800787/mir-449a-suppresses-ldha-mediated-glycolysis-to-enhance-the-sensitivity-of-non-small-cell-lung-cancer-cells-to-ionizing-radiation
#10
Liang Li, Huijuan Liu, Lianjiang Du, Pan Xi, Qian Wang, Yanqin Li, Di Liu
MicroRNA dysregulation contributes to malignant progression, dissemination and profound treatment resistance in multiple cancers. MiR-449a is recognized as a tumor suppresser. However, roles of miR-449a in lung cancers initiation and progression are largely unrevealed. Our study aims to investigate roles and the underlying mechanism of miR-449a in modulating sensitivity to ionizing radiation (IR) in non-small cell lung cancers (NSCLC). Lung cancer cells were transfected with miR-449a mimics or negative control and exposed to IR, levels of target protein, glycolysis, cell viability, apoptosis and DNA damage were examined...
August 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28800786/knockdown-of-long-noncoding-rna-linc0000125-suppresses-cellular-proliferation-and-invasion-in-glioma-cells-by-regulating-mir-4775
#11
Zhankun Zhu, Jinhua Dai, Yufeng Liao, Jianbo Ma, Wei Zhou
Long noncoding RNAs (lncRNAs) play an important role in various biological properties of glioma cells. Herein, we aimedto elucidate the function and the possible molecular mechanisms of long intergenic non-coding RNA 152 (LINC00152) in glioma cells. Relative expressions of LINC00152, miR-4775 and CDK6 in U-118 MG cells were regulated by transfections. Thereafter, cell viability, migration, invasion and apoptosis were analyzed by CCK8, Transwell and flow cytometry assays. Dual-luciferase reporter assay was conducted to validate the target genes of LINC00152 and miR-4775...
August 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28800785/mir-26b-mimic-inhibits-glioma-proliferation-in-vitro-and-in-vivo-suppressing-cox-2-expression
#12
Zheng-Gang Chen, Chuan-Yi Zheng, Wang-Qing Cai, Da-Wei Li, Fu-Yue Ye, Jian Zhou, Ran Wu, Kun Yang
Glioma is the most common malignant tumor of the nervous system. Studies have shown the microRNA (miR)-26b/cyclooxygenase (COX)-2 axis in the development and progression in many tumor cells. Our study aims to investigate the effect and mechanism of miR-26b/COX-2 axis in glioma. Decreased expression of miR-26b with increased level of COX-2 was found in glioma tissues compared with matched normal tissues. A strong negative correlation was observed between the level of miR-26b and COX-2 in 30 glioma tissues. The miR-26b was then overexpressed by transfecting miR-26b mimic into U-373 cells...
August 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28800784/upregulation-of-microrna-4262-targets-kaiso-zbtb33-to-inhibit-the-proliferation-and-emt-of-cervical-cancer-cells
#13
Jing Feng
More and more studies have reported that dysregulation of microRNAs (miRNAs) lead to the proliferation and EMT of multiple cancers. Recently, several reports have demonstrated that dysregulation of miR-4262 is in numerous cancers. However, its role and precise mechanism in human cervical cancer (CC) have not been well clarified. Hence, my study was aim to explore the biological roles and precise mechanisms of miR-4262 in CC cell lines. In my study, I found that the level of miR-4262 is significantly decreased in CC tissues and cell lines...
August 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28797320/decreased-expression-of-mir-138-5p-by-lncrna-h19-in-cervical-cancer-promotes-tumor-proliferation
#14
Lei Ou, Dazhong Wang, Han Zhang, Qian Yu, Fangfang Hua
MicroRNAs (miRNAs) play important roles in the carcinogenesis of cervical cancer. However, the expression and underlying mechanisms of miRNA in cervical cancer progression remain unclear. In the present study, our data showed that the expression of miR-138-5p was significantly downregulated in cervical cancer tissues, decreased expression of miR-138-5p was correlated with advanced FIGO stage, poor differentiation, lymph nodes metastasis, and poor overall survival of cervical cancer patients. Function assays showed that overexpression of miR-138-5p reduced cervical cancer cell proliferation, arrested cell in G0/G1 phase and induced cell apoptosis in vitro...
August 10, 2017: Oncology Research
https://www.readbyqxmd.com/read/28766482/self-reported-adherence-to-capecitabine-on-xelox-treatment-as-adjuvant-therapy-for-colorectal-cancer
#15
Kazuyoshi Kawakami, Takashi Yokokawa, Kazuo Sugita, Takahito Sugisaki, Kenichi Suzuki, Mitsukuni Suenaga, Kensei Yamaguchi, Ayaka Inoue, Yoshiaki Machida, Toshiharu Yamaguchi, Toshihiro Hama
Adherence has become an important issue in modern oncology treatment. Most studies have included heterogeneous target tumor types, regimens, and therapy settings. Our study focused on capecitabine during capecitabine plus oxaliplatin (XELOX) treatment as adjuvant therapy for colorectal cancer. The main aim of this study was to evaluate real-life adherence to capecitabine and to investigate candidate factors that might decrease adherence. We studied 338 consecutive patients who received XELOX treatment between December 1, 2011 and April 30, 2015 at the Cancer Institute Hospital of the Japanese Foundation for Cancer Research...
August 1, 2017: Oncology Research
https://www.readbyqxmd.com/read/28762326/long-noncoding-rna-urothelial-carcinoma-associated-1-promotes-the-proliferation-and-metastasis-of-human-lung-tumor-cells-by-regulating-microrna-144
#16
Dagang Li, Huizong Li, Yuping Yang, Le Kang
Long non-coding RNA urothelial carcinoma associated 1 (lncRNA UCA1) has gained more attention in recent years due to its oncogenic roles in various cancers. MicroRNA-144 (miR-144) participates in the regulation of many cancer cells growth. This study investigated the interaction between lncRNA UCA1 and miR-144 in lung cancer cells. The potential downstream protein of miR-144 was also assessed. Our results found that lncRNA UCA1 was highly expressed in human lung cancer A549, H517, H4006, H1299 and H1650 cells compared to normal embryonic lung WI-38 and HEL-1 cells...
August 1, 2017: Oncology Research
https://www.readbyqxmd.com/read/28748780/mir-133a-3p-targets-sumo-specific-protease-1-to-inhibit-cell-proliferation-and-cell-cycle-progress-in-colorectal-cancer
#17
Guo-Qiang Zhou, Fu Han, Zhi-Liang Shi, Liang Yu, Xue-Feng Li, Cheng Yu, Cheng-Long Shen, Dai-Wei Wan, Xin-Quo Zhu, Rui Li, Song-Bing He
Dysregulation of SUMO-specific protease 1(SENP1) expression has been reported in several kinds of cancer, including human colorectal and prostate cancers, proposing SENP1 as a oncogene with a critical role in cancer progression. MiR-133a-3p has been reported as a tumor suppressor in several malignant neoplasias. However, the precise molecular mechanisms underlying its role in colorectal cancer remain largely unknown. The aim of this work is to investigate the relationship between miR-133a-3p and SENP1 in colorectal cancer cells...
July 26, 2017: Oncology Research
https://www.readbyqxmd.com/read/28745272/long-noncoding-rna-hotair-an-oncogene-in-human-cervical-cancer-interacting-with-microrna-17-5p
#18
Fei Ji, Delinaer Wuerkenbieke, Yan He, Yan Ding
Increasing evidences have indicated that long noncoding RNAs (lncRNAs) are a class of significant regulator in varioustumorogenesis. LncRNA homeobox transcript antisense RNA (HOTAIR) has been reported to act as a functional lncRNA in cervical cancer development. In present study, our study aims to investigate the underlying mechanism of HOTAIR and miR-17-5p in cervical cancer tumorigenesis. Results showed that HOTAIR expression was significantly up-regulated both in cervical cancer tissues and cell lines. Loss-of-function experiments showed that HOTAIR knockdown inhibited the proliferation, migration and invasion of cervical cells...
July 26, 2017: Oncology Research
https://www.readbyqxmd.com/read/28762332/lncrna-neat1-promotes-proliferation-and-invasion-via-targeting-mir-181a-5p-in-non-small-cell-lung-cancer
#19
ShiDong Li, JiaMei Yang, Yubing Xia, QingXia Fan, Kun-Peng Yang
Long non-coding RNAs (lncRNAs) have been implicated in various biological processes and pathological conditions, including tumorigenesis. However, the exact roles of NEAT1 and its underlying mechanisms in non-small cell lung cancer (NSCLC) remain largely unclear. In the present study, lncRNA NEAT1 was detected to be significantly upregulated in NSCLC tissues and closely associated with advanced TNM stages, lymph node metastasis, distant metastasis and poor prognosis. Further experiments revealed that lncRNA NEAT1 silencing inhibited cell proliferation and invasion in vitro...
July 25, 2017: Oncology Research
https://www.readbyqxmd.com/read/28762328/emodin-induces-apoptosis-of-colon-cancer-cells-via-induction-of-autophagy-in-a-ros-dependent-manner
#20
Yuanyuan Wang, Qin Luo, Xianlu He, He Wei, Ting Wang, Jichun Shao, Xinni Jiang
Recent studies revealed that emodin extracted from Chinese herbs exhibits an anti-cancer effect on different cancer types, including colon cancer. However, the mechanism is not well understood by now. In our study, we confirmed that emodin treatment inhibited cell viability and induced apoptosis in colon cancer cells. Further experiments were taken to found that emodin was also able to induce autophagy, which is indispensible for apoptosis induced by it. More interestingly, emodin treatment also results in mitochondrial dysfunction and ROS accumulation in those colon cancer cells...
July 25, 2017: Oncology Research
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