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Oncology Research

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https://www.readbyqxmd.com/read/29137688/the-long-noncoding-rna-hotair-promotes-colorectal-cancer-progression-by-sponging-mir-197
#1
Xinyang Lu, Zhiqiang Liu, Xiaofei Ning, Lunhua Huang, Biao Jiang
The long non-coding RNA HOX transcript antisense RNA (HOTAIR) has been found overexpressed in many human malignancies and involved in tumor progression and metastasis. Although the downstream target through which HOTAIR modulates tumor metastasis is not well-known, evidence suggests that microRNA-197 (miR-197) might be involved in this event. In the present study, the significance of HOTAIR and miR-197 in the progression of colorectal cancer were detected in vitro and in vivo. We found that HOTAIR expression was significantly increased in colorectal cancer cells and tissues...
November 14, 2017: Oncology Research
https://www.readbyqxmd.com/read/29117881/downregulated-trophinin-associated-protein-plays-a-critical-role-in-human-hepatocellular-carcinoma-through-upregulation-of-tumor-cell-growth-and-migration
#2
Yifan Lian, Weiming Fan, Yanlin Huang, Hongbo Wang, Jialiang Wang, Liang Zhou, Xiaojuan Wu, Meihai Deng, Yuehua Huang
Trophinin Associated Protein (TROAP) was a protein first identified to mediate the process of embryo transplantation and later found to be involved in microtubule regulation. However, little is known about the role of TROAP in hepatocellular carcinoma (HCC). In the present study, we reported that both TROAP mRNA and protein expressions were downregulated in human HCC samples as well as cell lines. High level of TROAP was associated with small tumor size (P < 0.05), minor tumor nodules (P < 0.01) and mild vein invasion (P < 0...
November 8, 2017: Oncology Research
https://www.readbyqxmd.com/read/29089067/knockdown-of-long-non-coding-rna-lucat1-inhibits-cell-viability-and-invasion-by-regulating-mir-375-in-glioma
#3
Yan-Sheng Gao, Xian-Zhi Liu, Yong-Gang Zhang, Xian-Jin Liu, Ling-Zhen Li
Recently, long non-coding RNAs (lncRNAs) have emerged as new gene regulators and prognostic markers in several cancers,including glioma. Here, we focused on lncRNA LUCAT1 on the progression of glioma. QRT-PCR was used to determine the expression of LUCAT1 and miR-375 in glioma tissues and cells. MTT and transwell invasion assays were performed to determine the function of LUCAT1 in glioma progression. Bioinformatics tool DIANA was used to predict the targets of LUCAT1. Pearson's correlation analysis was performed to explore the correlation between LUCAT1 and miR-375...
October 24, 2017: Oncology Research
https://www.readbyqxmd.com/read/29046167/non-smc-condensin-i-complex-subunit-g-ncapg-is-a-novel-mitotic-gene-required-for-hepatocellular-cancer-cell-proliferation-and-migration
#4
Qun Zhang, Ruixia Su, Chun Shan, Chao Gao, Pei Wu
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Currently, only chemoembolization and sorafenib have shown survival benefits for advanced HCC. There are major unmet needs in HCC management and the discovery of new therapeutic targets. Here, we identified that NCAPG(non-SMC condensin I complex, subunit G) as a novel mitotic gene required for HCC cell proliferation and migration through siRNA knockdown of a panel of novel overexpressed genes in HCC based on The Cancer Genome Atlas (TCGA) dataset...
October 18, 2017: Oncology Research
https://www.readbyqxmd.com/read/29046165/long-term-use-of-nimotuzumab-in-combination-with-intensity-modulated-radiotherapy-and-chemotherapy-in-the-treatment-of-locoregionally-advanced-nasopharyngeal-carcinoma-experience-of-a-single-institution
#5
Wang Fangzheng, Jiang Chuner, Ye Zhiming, Liu Tongxin, Yan Fengqin, Wang Lei, Li Bin, Hu Fujun, Chen Ming, Qin Weifeng, Fu Zhenfu
In this retrospective review of a single institution's experience, the efficacy and safety of the long-term use of nimotuzumab in combination with intensity-modulated radiotherapy (IMRT) and chemotherapy in the treatment of locally advanced nasopharyngeal carcinoma (NPC) were studied. Between August 2008 and March 2014, 39 newly diagnosed patients with stage III–IV NPC were treated with IMRT, chemotherapy, and nimotuzumab. Twenty patients were diagnosed with stage III (51.3%), 14 with stage IVA (35.9%), and 5 with stage IVB (12...
October 18, 2017: Oncology Research
https://www.readbyqxmd.com/read/29137689/microrna-433-represses-proliferation-and-invasion-of-colon-cancer-cells-by-targeting-homeobox-a1
#6
Heming Li, Junfeng Li, Taisheng Yang, Shuwen Lin, Heng Li
The aberrant expression of miR-433 has been validated in some types of cancers. However, the expression profile and thebiological function of miR-433 on colon cancer are still elusive. This study was designed to investigate the function of miR-433 on proliferation and invasion of colon cancer cell. We detected the expression of miR-433 in colon cancer tissues, adjacent normal tissues and cell lines. CCK8 and transwell assays were performed to explore the impact of miR-433 on colon cancer cell proliferation and invasion...
October 3, 2017: Oncology Research
https://www.readbyqxmd.com/read/28950928/downregulation-of-microrna-147-inhibits-cell-proliferation-and-increases-the-chemosensitivity-of-gastric-cancer-cells-to-5-fluorouracil-by-directly-targeting-pten
#7
Jianjun Shen, Weina Niu, Hongbo Zhang, Ma Jun, Hongyan Zhang
Gastric cancer is the fourth most common malignancy and the third leading cause of cancer-related deaths worldwide. This study aimed to investigate the expression patterns, biological roles, and underlying mechanisms of microRNA-147 (miR-147) in gastric cancer. The present study demonstrated that miR-147 was significantly upregulated in gastric cancer tissues and cell lines. Downregulation of miR-147 decreased cell proliferation and enhanced the chemosensitivity of gastric cancer cells to 5-fluorouracil (5-FU) through the cell apoptosis pathway...
September 26, 2017: Oncology Research
https://www.readbyqxmd.com/read/28950927/mir-29a-inhibits-growth-and-metastasis-of-melanoma-a375-cells-by-directly-targeting-bmi1
#8
Ying Xiong, Liqian Liu, Ying Qiu, Lili Liu
Melanoma is one of the most aggressive malignant tumors, with increasing incidence, poor prognosis, and lack of any effective targeted therapy. Abnormal expression of miR-29a has been found in several types of cancers, including melanoma. However, the role of miR-29a in melanoma, and the molecular mechanism by which miR-29a represses melanoma are rarely reported. Cell transfection efficiency was determined by Quantitative real-time PCR or Western blot. The cell viability, apoptosis, migration, and invasion were respectively determined by Cell Counting Kit-8 assay, PI/FITC-Annexin V staining assay, wound healing assay and Transwell assay...
September 26, 2017: Oncology Research
https://www.readbyqxmd.com/read/28877783/g-protein-coupled-estrogen-receptor-antagonist-g15-decreases-estrogen-induced-development-of-non-small-cell-lung-cancer
#9
Changyu Liu, Yongde Liao, Sheng Fan, Xiangning Fu, Jing Xiong, Sheng Zhou, Man Zou, Jianmiao Wang
G-protein-coupled estrogen receptor (GPER) was found to promote Non-small cell lung cancer (NSCLC) by estrogen, indicating the potential necessity of inhibiting GPER by selective antagonist. This study was performed to elucidate the function of GPER selective inhibitor G15 in NSCLC development. Cytoplasmic GPER (cGPER) and nuclear GPER (nGPER) were detected by immunohistochemical analysis in NSCLC samples. The relation of GPER and estrogen receptor β (ERβ) expression and correlation between GPER, ERβ and clinical factors were analyzed...
September 25, 2017: Oncology Research
https://www.readbyqxmd.com/read/28923134/%C3%A3-1-3-galactosyl-o-glycosyl-glycoprotein-%C3%A3-1-6-n-acetylglucosaminyltransferase-3-increases-mcam-stability-which-enhances-s100a8-a9-mediated-cancer-motility
#10
I Wayan Sumardika, Chen Youyi, Eisaku Kondo, Yusuke Inoue, I Made Winarsa Ruma, Hitoshi Murata, Rie Kinoshita, Ken-Ichi Yamamoto, Shuta Tomida, Kazuhiko Shien, Hiroki Satoh, Akira Yamauchi, Junichiro Futami, Endy Widya Putranto, Toshihiko Hibino, Shinichi Toyooka, Masahiro Nishibori, Masakiyo Sakaguchi
We previously identified novel S100A8/A9 receptors, Extracellular Matrix Metalloproteinase Inducer (EMMPRIN), MelanomaCell Adhesion Molecule (MCAM), Activated Leukocyte Cell Adhesion Molecule (ALCAM) and Neuroplastin (NPTN) ß, that are critically involved in S100A8/A9-mediated cancer metastasis and inflammation when expressed at high levels. However, little is known about the presence of any cancerspecific mechanism(s) that modifies these receptors, further inducing upregulation at protein levels without any transcriptional regulation...
September 18, 2017: Oncology Research
https://www.readbyqxmd.com/read/28915933/mir-1290-contributes-to-colorectal-cancer-cell-proliferation-by-targeting-inpp4b
#11
Qingzhu Ma, Yan Wang, Hualing Zhang, Fengqiang Wang
Colorectal cancer (CRC) is one of the most common oncological conditions s worldwide, to date, MicroRNA 1290 (miRNA) has been demonstrated to regulate its progression. We studied the role of miR-1290 in CRC progression. The gene was upregulated in CRC tissues and cells, its overexpression promoted CRC cell proliferation analyzed by MTT assay, colony formation assay and soft agar growth assay. IN addition, miR-1290 knockdown inhibited CRC cell proliferation. We also found that miR-1290 overexpression reduced p27 level and increased Cyclin D1 level both in mRNA and protein levels, while miR-1290 knockdown increased p27 and reduced Cyclin D1 (confirming miR-1290 promoted CRC cell proliferation)...
September 15, 2017: Oncology Research
https://www.readbyqxmd.com/read/28911342/efficacy-and-safety-of-transcatheter-arterial-chemoembolization-and-transcatheter-arterial-chemotherapy-infusion-in-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#12
Xinyang Liu, Zhichao Wang, Zongwei Chen, Longzi Liu, Lijie Ma, Liangqing Dong, Zhao Zhang, Shu Zhang, Liuxiao Yang, Jieyi Shi, Jia Fan, Xiaoying Wang, Qiang Gao
Hepatocellular carcinoma (HCC) is a worldwide health threat with increasing incidence and high mortality rate. Most HCCpatients are diagnosed at an advanced stage, and are unable to undergo potential curative surgery. Transcatheter arterial chemoembolization (TACE) and transcatheter arterial chemotherapy infusion (TACI) are two main palliative treatments for advanced HCC patients. The clinical efficacy and safety of TACE and TACI are controversial. For this reason, we conducted the current systematic review and meta-analysis to summarize current evidence...
September 14, 2017: Oncology Research
https://www.readbyqxmd.com/read/28911340/ursolic-acid-attenuates-tgf-%C3%AE-1-induced-epithelial-mesenchymal-transition-in-nsclc-by-targeting-integrin-%C3%AE-v%C3%AE-5-mmps-signaling
#13
Jun Shan Ruan, Huan Zhou, Lin Yang, Ling Wang, Zong Sheng Jiang, Hong Sun, Shao Ming Wang
Transforming growth factor-β1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) of non-small-cell carcinoma (NSCLC) may contribute to tumor metastasis. TGF-β1-induced EMT in H1975 cells (a human NSCLC cell line) resulted in the adoption of mesenchymal responses that were predominantly mediated via the TGF-β1-integrin signaling pathway. Ursolic acid has been previously reported to inhibit tumor growth and metastasis in several cancers. However, whether ursolic acid can attenuate TGF-β1-induced EMT in H1975 cells and its underlying mechanisms remains unknown...
September 14, 2017: Oncology Research
https://www.readbyqxmd.com/read/28899458/long-noncoding-rna-malat1-functions-as-a-sponge-of-mir-200c-in-ovarian-cancer
#14
Meili Pa, Gulimire Naizaer, Ayinuer Seyiti, Gulina Kuerbang
Previous researches have revealed that alteration of non-coding RNAs expression level in malignancies can significantlymodify the course of diseases. Current study was aimed to investigate the biological functions of lncRNA MALAT1 and miR-200c, as well as the interaction between them. Quantitative real-time polymerase chain reaction (qRT-PCR) showed that lncRNA MALAT1 was overexpressed in ovarian cancer tissues and cell lines in compare to adjacent normal tissue and normal human ovarian surface epithelial cells (HOSEPiCs)...
September 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28899456/clc5-decreases-the-sensitivity-of-multiple-myeloma-cells-to-bortezomib-via-promoting-pro-survival-autophagy
#15
Huimin Zhang, Yuhui Pang, Chuanbao Ma, Jianying Li, Huaquan Wang, Zonghong Shao
Resistance to bortezomib (BZ) is the major problem that largely limits its clinical application in multiple myeloma treatment. In current study, we investigated whether ClC5, a member of the chloride channel family, involved in this process. The results of MTT assay showed that BZ treatment decreased cell viability in three multiple myeloma cell lines (ARH77, U266 and SKO-007), with the IC50 value of 2.83 nM, 4.37 nM and 1.91 nM, respectively. Moreover, BZ increased the conversion of LC3B-I to LC3B-II and expressions of Beclin-1 and ATG5, concomitantly with decreased p62 expression...
September 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28899455/mitotic-arrest-deficient-protein-2b-overexpressed-in-lung-cancer-promotes-proliferation-emt-and-metastasis
#16
Hua Zhang, Xiuquan He, Wenfei Yu, Bingqing Yue, Ziting Yu, Ying Qin
As the non-catalytic subunit of mammalian DNA polymerase, mitotic arrest-deficient protein 2B (MAD2B) has been reportedto play a role in cell-cycle regulation, DNA damage tolerance, gene expression and carcinogenesis. Although its expression is known to be associated with poor prognosis in several types of human cancers, the significance of MAD2B expression in lung malignancies is still unclear. Our study showed that MAD2B expression significantly increased in lung cancer, especially in the metastatic tissues...
September 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28899457/swainsonine-inhibits-invasion-and-the-emt-process-in-esophageal-carcinoma-cells-by-targeting-twist1
#17
Junxun Ma, Lijie Wan, Jinyu Li, Guoqing Zhang, Haitao Tao, Xiaoyan Li, Danyang Sun, Yi Hu
Esophageal cancer is a common gastrointestinal cancer, with a very high mortality rate in patients with metastasis. Swainsonine, a cytotoxic fungal alkaloid, has been shown to inhibit cell growth in esophageal cancer. In the present study, we explored the effects of swainsonine on cell invasion and metastasis in esophageal cancer cells. Human esophageal carcinoma cells were treated with different doses of swainsonine, and then cell viability, invasion and apoptosis were measured, respectively. The mRNA and protein expressions of Twist1, apoptosis- and EMT-related factors and PI3K/AKT pathway factors were detected by qRT-PCR and western blot...
September 6, 2017: Oncology Research
https://www.readbyqxmd.com/read/28893350/knockdown-of-gab1-inhibits-cellular-proliferation-migration-and-invasion-in-human-oral-squamous-carcinoma-cells
#18
Luyong Xu, Jie Li, Zheng Kuang, Yan Kuang, Hong Wu
Grb2-associated binder 1 (Gab1) is often aberrant in cancerous cells and tissues, whose alteration is to be responsiblefor aggressive phenotypes. In this study, we examined the Gab1 expression in human oral squamous cell carcinoma (OSCC) tissues and investigated the cellular and molecular effect of Gab1 on migration, invasion and cell growth of OSCC cell lines SCC15 and SCC25. We found Gab1 was over-expressed in OSCC tissues and cells, which is related to the protein levels of various molecules associated with cellular proliferation, migration, and invasion...
September 6, 2017: Oncology Research
https://www.readbyqxmd.com/read/28893348/overexpression-of-glypican-5-gpc5-inhibits-prostate-cancer-cell-proliferation-and-invasion-via-suppressing-sp1-mediated-emt-and-activation-of-wnt-%C3%AE-catenin-signaling
#19
Yu Sun, Kai Xu, Miao He, Guilian Fan, Hongming Lu
Glypican 5 (GPC5) belongs to the family of heparan sulfate proteoglycans (HSPGs). It was initially known as a regulatorof growth factors and morphogens. Recently, there have been reports on its correlation with the tumorigenic process in the development of some cancers. However, little is known about its precise role in prostate cancer (PCa). In the present study, we explored the expression pattern and biological functions of GPC5 in PCa cells. Our results showed that GPC5 was lowly expressed in PCa cell lines...
September 6, 2017: Oncology Research
https://www.readbyqxmd.com/read/28893347/mir-203-suppresses-bladder-cancer-cell-growth-and-targets-the-twist1
#20
Jie Shen, Jianhua Zhang, Minhui Xiao, Junfeng Yang, Ningnan Zhang
MiR-203 is an epigenetically silenced tumor-suppressive microRNA in tumors. This study was designed to investigate theeffects of miR-203 on the proliferation, migration, invasion and apoptosis of bladder cancer (BCa) cells. The expression levels of miR-203 in BCa tissues, the normal adjacent tissues, and the BCa cell lines were detected. BCa cells were transfected with miR-203 mimic and inhibitor to investigate the effect of miR-203 on cell functions and the epithelial mesenchymal transition (EMT). Cotransfection with miR-203 inhibitor and shRNA of the predicted target gene Twist1 (si-Twist1) was performed to investigate the target relationship of miR-203 and Twist1...
September 6, 2017: Oncology Research
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