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Oncology Research

Yaohong Liu, Wensou Huang, Mingji He, Hui Lian, Yongjian Guo, Jingjun Huang, Jingwen Zhou, Kangshun Zhu
This study aimed to investigate the efficacy and safety of drug eluting beads transarterial chemoembolization (DEB-TACE) treatment in Barcelona Clinic Liver Cancer (BCLC) stage C liver cancer patients. In 39 patients with BCLC stage C liver cancer, after the first cycle of DEB-TACE, 2 (5.1%) and 24 (61.5%) patients achieved complete response (CR) and partial response (PR) to give an overall objective response rate (ORR) of 66.7%. With respect to the second cycle of therapy, the ORR was higher in patients receiving DEB-TACE compared with cTACE (57...
July 13, 2018: Oncology Research
Jing Tang, Xu Yong Li, Jing Bo Liang, De Wu, Li Peng, Xiaobing Li
Apatinib is an oral TKI with anti-angiogenesis properties, and it is currently approved for the treatment of advanced gastric cancer in China. This agent has also been tested in other human solid tumors, including non-small cell lung cancer (NSCLC). Since the combination of chemotherapy and an anti-angiogenesis agent has been shown to be feasible strategy in NSCLC, it is conceivable that a similar approach combining apatinib with chemotherapy may yield clinical activity. With this in mind, we investigated the efficiency of apatinib in combination with pemetrexed or docetaxel in advanced NSCLC...
June 21, 2018: Oncology Research
Yuma Nonomiya, Takashi Yokokawa, Kazuyoshi Kawakami, Kazuo Kobayashi, Takeshi Aoyama, Tomomi Takiguchi, Takahito Sugisaki, Kenichi Suzuki, Mitsukuni Suenaga, Takeru Wakatsuki, Kensei Yamaguchi, Yoshikazu Sugimoto, Toshihiro Hama
Regorafenib is a multikinase inhibitor for the treatment of metastatic colorectal cancer. Regorafenib-induced hand-footskin reaction (HFSR) is a common side effect during treatment. The reported frequency of HFSR was 80% (Grade 3: 28%) of the Japanese subpopulation in the CORRECT trial; however, more detailed data regarding HFSR in terms of onset and sites of susceptibility are unclear. Additionally, the risk factors for regorafenib-induced severe HFSR are unknown. The aim of this study was to compare HFSR between the hands and feet and identify pre-existing risk factors for severe HFSR in Japanese patients receiving regorafenib...
June 18, 2018: Oncology Research
Qiaodong Xu, Songgang Gu, Jiahong Liang, Zhihua Lin, Shaodong Zheng, Jiang Yan
Hepatocellular carcinoma (HCC) is one of the major malignant tumors leading to death. Chronic hepatitis B virus infection is an important risk factor for HCC initiation. HBx protein, encoded by HBV X gene, is a significant factor that promotes HBV related HCC, although the exact molecular mechanism remains unclear. This article summarizes the pathological roles and related mechanisms of HBx in HCC. HBx plays a carcinogenic role by promoting cell proliferation and metastasis, angiogenesis and inhibiting apoptosis in HCC...
June 1, 2018: Oncology Research
Jia Liu, Ying Zhang, Shulan Sun, Guirong Zhang, Ke Jiang, Peixin Sun, Ye Zhang, Bing Yao, Rui Sui, Yi Chen, Xu Guo, Ji Shi, Haiyang Liang, Haozhe Piao
Glioma is the most common malignant tumor of the central nervous system and it is characterized by high relapse and fatality rates and poor prognosis. Bufalin is one of the main ingredients of Chan-su, a traditional Chinese medicine (TCM) extracted from toad venom. Previous studies revealed that bufalin exerted inhibitory effects on a variety of tumor cells. To demonstrate the inhibitory effect of bufalin on glioma cells and glioma stem-like cells (GSCs) and discuss the underlying mechanism, the proliferation of glioma cells was detected by MTT and colony formation assays following treatment with bufalin...
May 24, 2018: Oncology Research
Liping Xue, Bin Lu, Bibo Gao, Yangyang Shi, Jingqi Xu, Rui Yang, Bo Xu, Peng Ding
Due to the characteristics of high invasiveness, relapse and poor prognosis, the management of malignant gliomas has always been a great challenge. Nod-like receptor (NLR) family pyrin domain containing 3 (NLRP3) is a crucial component of the NLRP3 inflammasome, a multiprotein complex that can triggercaspase-1/interleukin-1 (IL-1) mediated inflammatory response once activated and participates in the pathogeny of diverse inflammatory diseases as well as cancers. Herein, we examined the function of NLRP3 in the development of glioma...
May 16, 2018: Oncology Research
Qing Yang, Xiaosheng Jin, Fangpeng Ye, Bingru Zheng, Xiangpang Xie, Ya Luo, Zhenjing Shi, Changsheng Shi
The aim of this study was to explore the difference of liver function change, safety profiles and efficacy of drug-eluting bead transarterial chemoembolization (DEBTACE) therapy between elderly and middle-aged hepatocellular carcinoma (HCC) patients. 91 HCC patients were enrolled in this prospective cohort study. They were treated by DEB-TACE therapy and divided into elderly group (age >= 65 years, n=30) and middle-aged group (age < 65 years, n=61), liver function, safety profiles and treatment response were recorded...
May 8, 2018: Oncology Research
Dan Shan, Yumin Shang, Tongxiu Hu
Cervical cancer is the third most common gynecological cancer and the fourth leading cause of cancer-related deaths inwomen around the world. Substantial evidence has proved that microRNA (miRNA) expression is disordered in many malignant tumors. The dysregulation of miRNAs has been suggested to be involved in the tumorigenesis and tumor development of cervical cancer. Therefore, identification of miRNAs and their biological roles and targets involved in tumor pathology would provide valuable insight into the diagnosis and treatment of patients with cervical cancer...
May 1, 2018: Oncology Research
Hao Chen, Yi Zhang, Hai Su, Hui Shi, Qijiang Xiong, Zulu Su
It is well known that activating transcription factor 4 (ATF4) expression is closely associated with progression of many cancers. And we found that miR-1283 could directly target the ATF4. However, the precise mechanisms of miR-1283 in glioma have not been well clarified. Our study aimed to explore the interaction between ATF4 and miR-1283 in glioma. In this study, we found that the level of miR-1283 was dramatically decreased in glioma tissues and cell lines, and the expression of ATF4 was significantly increased...
May 1, 2018: Oncology Research
Lili Zhao, Yao Zhang, Jiaoxia Liu, Wei Yin, Dan Jin, Dandan Wang, Wei Zhang
MicroRNAs are short endogenous non-coding RNAs, which can frequently emerge as regulators in many cancer types. It wasdemonstrated in the research that miR-185 expression levels were remarkably down-regulated in NSCLC tissues than in adjacent normal tissues. Lower miR-185 expression levels were definitely associated with lymph node metastasis. Functional assays showed that up-regulated miR-185 expression in NSCLC cells could inhibit the cell propagation, cell colony formation and incursion capacities in vitro...
May 1, 2018: Oncology Research
Yong Zhang, Qingfeng Dai, Fanying Zeng, Haichun Liu
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long noncoding RNA (lncRNA) that contributes to the initiation and development of many solid tumors, including osteosarcoma (OS). In this study, we showed that MALAT1 was increased in human OS tissues and cell lines. MALAT1 knockdown suppressed OS cell growth and metastasis, induced OS cell apoptosis and delayed tumor growth in an OS xenograft model. We also detected downregulation of microRNA-509 (miR-509), a suppressor of OS growth, in OS tissues and cell lines...
April 27, 2018: Oncology Research
Xiyan Sun, Chao Zhang, Yang Cao, Erbiao Liu
MiR-150 has been demonstrated to inhibit tumor progression in various human cancers, including colorectal cancer, ovarian cancer and thyroid cancer. However, the role of miR-150 in melanoma remains to be determined. In this study, we found that miR-150 was underexpressed in melanoma tissues and cell lines. Through transfection of miR-150 mimics, we found that miR-150 significantly inhibited the proliferation, migration and invasion of melanoma cells. In mechanism, we found that MYB was a target of miR-150 in melanoma cells...
April 24, 2018: Oncology Research
Cheng Zhang, Jing-Yi Li, Fu-Zhou Tian, Gang Zhao, Hai Hu, Yue-Feng Ma, Yu-Long Yang
Long noncoding RNAs (lncRNAs) are known to play important roles in cancers. However, little is known about lncRNAs in cholangiocarcinoma (CCA), a cholangiocyte malignancy with poor prognosis. We investigated the role of nuclear paraspeckle assembly transcript 1 (NEAT1) lncRNA in promoting CCA. qRT-PCR analysis of patient samples showed that NEAT1 expression was higher in CCA tumors than in matched adjacent nontumor tissue. NEAT1 levels were also higher in CCA cell lines than in a normal biliary epithelium cell line (HIBEpic)...
July 5, 2018: Oncology Research
Yuping Shen, Chunyan Li, Weixing Liu, Wei Mao, Hong Qian, Hui Wang, Qing Xu
This study investigated the characteristics of oxaliplatin-induced hypersensitivity reactions (HSRs) and evaluated the efficacy of premedication for controlling HSRs among colorectal cancer patients. A retrospective study was performed on the clinical records of 291 patients with colorectal cancer in The Tenth People's Hospital of Shanghai from January 2008 to January 2016. Patients who experienced HSRs to oxaliplatin were compared with those who did not. A total of 291 colorectal cancer patients received oxaliplatin, with 39 (13...
June 11, 2018: Oncology Research
Nan Li, Hangyu Shi, Lu Zhang, Xu Li, Lu Gao, Gang Zhang, Yongqiang Shi, Shiwen Guo
MicroRNAs (miRNAs) play important roles in several human cancers. Although miR-188 has been suggested to function as a tumor repressor in cancers, its precise role in glioma and the molecular mechanism remain unknown. In the present study, we investigated the effect of miR-188 on glioma and explored its relevant mechanisms. We found that the expression of miR-188 is dramatically downregulated in glioma tissues and cell lines. Subsequent investigation revealed that miR-188 expression was inversely correlated with β-catenin expression in glioma tissue samples...
June 11, 2018: Oncology Research
Lili Lv, Xiaodong Wang
Cervical cancer is the third most commonly diagnosed malignancy and the fourth leading cause of cancer-related deaths in women worldwide. MicroRNA-296 (miR-296) is aberrantly expressed in a variety of human cancer types. However, the expression levels, biological roles, and underlying molecular mechanisms of miR-296 in cervical cancer remain unclear. This study aimed to detect miR-296 expression in cervical cancer and evaluate its roles and underlying mechanisms in cervical cancer. This study demonstrated that miR-296 was significantly downregulated in cervical cancer tissues and cell lines...
June 11, 2018: Oncology Research
Ting Liu, Fang Liu, Lei-Wen Peng, Li Chang, Yong-Mei Jiang
Peritoneal macrophages (PMs) are the major cell type of peritoneal cells that participate in multiple aspects of innate and acquired immunity in the peritoneal cavity. PMs have an ability to release a large amount of proinflammatory and anti-inflammatory cytokines and therefore play a critical role in regulating the differentiation of innate immune cells and inflammatory T cells. Accumulating studies demonstrate that the immunological reactions and inflammatory responses of PMs are strongly related to the pathogenic processes of various inflammatory diseases and abdominal cancers...
June 11, 2018: Oncology Research
Amanda Ikegami, Luiz Felipe S Teixeira, Marina S Braga, Matheus Henrique Dos S Dias, Eduardo C Lopes, Maria Helena Bellini
Renal cell carcinoma (RCC) accounts for approximately 2%-3% of human malignancies and is the most aggressive among urologic tumors. Biological heterogeneity, drug resistance, and chemotherapy side effects are the biggest obstacles to the effective treatment of RCC. The NF-κB transcription factor is one of several molecules identified to be responsible for the aggressive phenotype of this tumor. In the past decade, several studies have demonstrated the activation of NF-κB in RCC, and many have implicated NF-κB1 (p50) as an important molecule in tumor progression and metastasis...
June 11, 2018: Oncology Research
Hui Meng, Lei Han, Chun Hong, Jinya Ding, Qianchuan Huang
Multiple myeloma (MM), a type of malignant tumor, is characterized by dysplasia of clonal plasma cells in the bone marrow. People with MM will have damaged organs or tissues due to secretion of large amounts of monoclonal immunoglobulin or fragments (M protein). Despite improved survivability by novel treatment strategies over the last decade, MM is still incurable by current therapies. Long noncoding RNAs (lncRNAs), with length of more than 200 nucleotides, have been reported to act as important regulators in many diseases, including MM...
June 11, 2018: Oncology Research
Caiyu Jiang, Yan Yang, Yang Yang, Lu Guo, Jiang Huang, Xingren Liu, Chi Wu, Jun Zou
Non-small cell lung cancer (NSCLC) is one of the most deadly cancers with poor prognosis. Recent findings suggested that the lncRNA HOTAIR played an important role in tumorigenesis and metastasis. In the present study, HOTAIR was highly expressed in NSCLC tumor tissues and cell lines (H1299, H23, H292, and A549). Downregulation of HOTAIR suppressed cell proliferation and invasion, while it promoted apoptosis of NSCLC cells. The targeting relationship between HOTAIR and miR-613 was first revealed by bioinformatics prediction...
June 11, 2018: Oncology Research
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