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Oncology Research

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https://www.readbyqxmd.com/read/29769161/nlrp3-promotes-glioma-cell-proliferation-and-invasion-via-the-interleukin-1%C3%AE-nf-%C3%AE%C2%BAb-p65-signals
#1
Liping Xue, Bin Lu, Bibo Gao, Yangyang Shi, Jingqi Xu, Rui Yang, Bo Xu, Peng Ding
Due to the characteristics of high invasiveness, relapse and poor prognosis, the management of malignant gliomas has always been a great challenge. Nod-like receptor (NLR) family pyrin domain containing 3 (NLRP3) is a crucial component of the NLRP3 inflammasome, a multiprotein complex that can triggercaspase-1/interleukin-1 (IL-1) mediated inflammatory response once activated and participates in the pathogeny of diverse inflammatory diseases as well as cancers. Herein, we examined the function of NLRP3 in the development of glioma...
May 16, 2018: Oncology Research
https://www.readbyqxmd.com/read/29739489/safety-and-efficacy-analysis-of-deb-tace-treatment-in-elderly-patients-with-hepatocellular-carcinoma-a-comparative-cohort-study
#2
Qing Yang, Xiaosheng Jin, Fangpeng Ye, Bingru Zheng, Xiangpang Xie, Ya Luo, Zhenjing Shi, Changsheng Shi
The aim of this study was to explore the difference of liver function change, safety profiles and efficacy of drug-eluting bead transarterial chemoembolization (DEBTACE) therapy between elderly and middle-aged hepatocellular carcinoma (HCC) patients. 91 HCC patients were enrolled in this prospective cohort study. They were treated by DEB-TACE therapy and divided into elderly group (age >= 65 years, n=30) and middle-aged group (age < 65 years, n=61), liver function, safety profiles and treatment response were recorded...
May 8, 2018: Oncology Research
https://www.readbyqxmd.com/read/29716674/microrna-411-inhibits-cervical-cancer-progression-by-directly-targeting-stat3
#3
Dan Shan, Yumin Shang, Tongxiu Hu
Cervical cancer is the third most common gynecological cancer and the fourth leading cause of cancer-related deaths inwomen around the world. Substantial evidence has proved that microRNA (miRNA) expression is disordered in many malignant tumors. The dysregulation of miRNAs has been suggested to be involved in the tumorigenesis and tumor development of cervical cancer. Therefore, identification of miRNAs and their biological roles and targets involved in tumor pathology would provide valuable insight into the diagnosis and treatment of patients with cervical cancer...
May 1, 2018: Oncology Research
https://www.readbyqxmd.com/read/29716673/overexpression-of-mir-1283-inhibits-cell-proliferation-and-invasion-of-glioma-cells-by-targeting-atf4
#4
Hao Chen, Yi Zhang, Hai Su, Hui Shi, Qijiang Xiong, Zulu Su
It is well known that activating transcription factor 4 (ATF4) expression is closely associated with progression of many cancers. And we found that miR-1283 could directly target the ATF4. However, the precise mechanisms of miR-1283 in glioma have not been well clarified. Our study aimed to explore the interaction between ATF4 and miR-1283 in glioma. In this study, we found that the level of miR-1283 was dramatically decreased in glioma tissues and cell lines, and the expression of ATF4 was significantly increased...
May 1, 2018: Oncology Research
https://www.readbyqxmd.com/read/29716672/mir-185-inhibits-cell-proliferation-and-invasion-of-non-small-cell-lung-cancer-by-targeting-klf7
#5
Lili Zhao, Yao Zhang, Jiaoxia Liu, Wei Yin, Dan Jin, Dandan Wang, Wei Zhang
MicroRNAs are short endogenous non-coding RNAs, which can frequently emerge as regulators in many cancer types. It wasdemonstrated in the research that miR-185 expression levels were remarkably down-regulated in NSCLC tissues than in adjacent normal tissues. Lower miR-185 expression levels were definitely associated with lymph node metastasis. Functional assays showed that up-regulated miR-185 expression in NSCLC cells could inhibit the cell propagation, cell colony formation and incursion capacities in vitro...
May 1, 2018: Oncology Research
https://www.readbyqxmd.com/read/28560950/malat1-promotes-the-proliferation-and-metastasis-of-osteosarcoma-cells-by-activating-the-rac1-jnk-pathway-via-targeting-mir-509
#6
Yong Zhang, Qingfeng Dai, Fanying Zeng, Haichun Liu
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long noncoding RNA (lncRNA) that contributes to the initiation and development of many solid tumors, including osteosarcoma (OS). In this study, we showed that MALAT1 was increased in human OS tissues and cell lines. MALAT1 knockdown suppressed OS cell growth and metastasis, induced OS cell apoptosis and delayed tumor growth in an OS xenograft model. We also detected downregulation of microRNA-509 (miR-509), a suppressor of OS growth, in OS tissues and cell lines...
April 27, 2018: Oncology Research
https://www.readbyqxmd.com/read/29690954/mir-150-suppresses-tumor-growth-in-melanoma-through-downregulation-of-myb
#7
Xiyan Sun, Chao Zhang, Yang Cao, Erbiao Liu
MiR-150 has been demonstrated to inhibit tumor progression in various human cancers, including colorectal cancer, ovarian cancer and thyroid cancer. However, the role of miR-150 in melanoma remains to be determined. In this study, we found that miR-150 was underexpressed in melanoma tissues and cell lines. Through transfection of miR-150 mimics, we found that miR-150 significantly inhibited the proliferation, migration and invasion of melanoma cells. In mechanism, we found that MYB was a target of miR-150 in melanoma cells...
April 24, 2018: Oncology Research
https://www.readbyqxmd.com/read/29678219/lncrna-mnx1-as1-promotes-glioblastoma-progression-through-inhibition-of-mir-4443
#8
Yan Gao, Yongchuan Xu, Jue Wang, Xue Yang, Lulu Wen, Juan Feng
Long noncoding RNAs (lncRNAs) have been acknowledged as important regulators in various human cancers. LncRNA MNX1-AS1has been shown to be an oncogene in epithelial ovarian cancer. However, the function of MNX1-AS1 in glioblastoma (GBM) remains largely unknown. Here, we found that the expression of MNX1-AS1 was significantly upregulated in GBM tissues and cell lines. Knockdown of MNX1-AS1 significantly inhibited the proliferation, migration and invasion of GBM cells. In terms of mechanism, we found that MNX1-AS1 could bind to miR-4443 in GBM cells...
April 20, 2018: Oncology Research
https://www.readbyqxmd.com/read/29673423/experimental-and-in-silico-analysis-of-cordycepin-and-its-derivatives-as-endometrial-cancer-treatment
#9
Pedro Fong, Cheng N Ao, Kai I Tou, Ka M Huang, Chi C Cheong, Li R Meng
The aim of this study was to investigate the inhibition effects of cordycepin and its derivatives on endometrial cancercell growth. Cytotoxicity MTT assays, clonogenic assays and flow cytometry were used to observe the effects on apoptosis and regulation of the cell cycle of Ishikawa cells under various concentrations of cordycepin, cisplatin and combinations of the two. Validated in silico docking simulations were performed on 31 cordycepin derivatives against adenosine deaminase (ADA) to predict their binding affinities and hence their potential tendency to be metabolized by ADA...
April 19, 2018: Oncology Research
https://www.readbyqxmd.com/read/29673422/pokemon-mir-137-auto-regulatory-circuit-promotes-the-progression-of-renal-carcinoma
#10
Lihui Wang, Qi Li, Zhuo Ye, Baoping Qiao
Renal carcinoma greatly threatens human health, but the involved molecular mechanisms are far from complete understanding. As a master oncogene driving the initiation of many other cancers, Pokemon has not been established to be associated with renal cancer. Our data revealed that Pokemon is highly expressed in renal carcinoma specimen and cell lines, compared with normal cells. The silencing of Pokemon suppressed the proliferation and invasion of renal cancer cells. Pokemon overexpression rendered normal cells with higher proliferation rates and invasiveness...
April 19, 2018: Oncology Research
https://www.readbyqxmd.com/read/29673421/long-noncoding-rna-linc01296-harbors-mir-21a-to-regulate-colon-carcinoma-proliferation-and-invasion
#11
Kecheng Wang, Meng Zhang, Cong Wang, Xiaofei Ning
Increasing evidences have demonstrated that aberrant expressions of long non-coding RNAs (lncRNAs) are closely correlated to various malignancies, as well as colon carcinoma (CC). The aim of this study was to investigate the role of lncRNA long intergenic noncoding RNA 001296 (LINC01296) in tumorigenesis of CC. The result of the quantitative real-time polymerase chain reaction (qRT-PCR) demonstrated that LINC01296 was upregulated in CC cancerous tissues and cell lines compared to adjacent normal tissue and normal liver cell lines...
April 19, 2018: Oncology Research
https://www.readbyqxmd.com/read/29739490/kaempferol-suppresses-proliferation-and-induces-cell-cycle-arrest-apoptosis-and-dna-damage-in-breast-cancer-cells
#12
Li Zhu, Lijun Xue
Kaempferol is a flavonoid that has been extensively investigated owing to its antitumor effects. Nevertheless, little is known about its underlying mechanisms of action. We aimed to explore the role of kaempferol in breast cancer (BC), and thus, we investigated how kaempferol suppresses the growth of BC cells. The cells were treated with kaempferol and the effects on multiple cancer-associated pathways were evaluated. The MTS assay was used to study the cell growth inhibition induced by kaempferol. The cell cycle (CC) was analyzed by flow cytometry...
April 3, 2018: Oncology Research
https://www.readbyqxmd.com/read/29615150/lncrna-bcar4-increases-viability-invasion-and-migration-non-small-cell-lung-cancer-cells-by-targeting-glioma-associated-oncogene-2-gli2
#13
Hongliang Yang, Lei Yan, Kai Sun, Xiaodong Sun, Xudong Zhang, Kerui Cai, Tiejun Song
OBJECTIVE: This study was aimed to explore the effects of lncRNA BCAR4 on the viability and aggressiveness of non-smallcell lung cancer (NSCLC) cells. METHODS: qRTPCR was used to determine the expression of lncRNA BCAR4 and GLI2 downstream genes in NSCLC tissues and cell lines. Chromatin isolation by RNA purification (CHIRP) and western blot were employed to measure the expression of GLI2 downstream proteins. Ki67 expression in nude mice tumors was tested by immunohistochemistry...
April 3, 2018: Oncology Research
https://www.readbyqxmd.com/read/29615149/mir-455-functions-as-a-tumor-suppressor-through-targeting-gata6-in-colorectal-cancer
#14
Hua Yunqi, Yin Fangrui, Yang Yongyan, Jin Yunjian, Zhang Wenhui, Cao Kun, Li Min, Liu Xianfeng, Ba Caixia
Emerging evidence indicates microRNAs (miRNAs) are often aberrantly expressed in human cancers. Meanwhile, the importance of miRNAs in regulating multiplies cellular biological processes has been appreciated. The aim of this study was to investigate the significance of miR-455 and identify its possible mechanism in regulating colorectal cancer (CRC) progression. We found the expression of miR-455 was sharply reduced in CRC tissues and cell lines. Importantly, the low expression of miR-455 was associated with poor overall survival of CRC patients...
April 3, 2018: Oncology Research
https://www.readbyqxmd.com/read/29615148/microrna-495-inhibits-proliferation-metastasis-and-promotes-apoptosis-by-targeting-twist1-in-gastric-cancer-cells
#15
Chao Liu, Min Jian, Hong Qi, Wei-Zheng Mao
Recently, microRNAs (miRNAs) have reported to participate in multiple biological processes. However, the effects of miR-495 on gastric cancer (GC) remain unclear. The purpose of this study is to explore the functions of miR-495 in GC cells proliferation, metastasis and apoptosis. SGC-7901 and BGC-823 were transfected with miR-495 mimic, miR-495 inhibitor and negative controls (mimic control and inhibitor control). The expressions of miR-495, cell viability, migration, apoptosis and apoptosis-related factors were examined by qRT-PCR, trypan blue staining, Transwell, flow cytometry and western blot, respectively...
April 3, 2018: Oncology Research
https://www.readbyqxmd.com/read/29615147/mir-223-5p-suppresses-tumor-growth-and-metastasis-in-non-small-cell-lung-cancer-by-targeting-e2f8
#16
Liyan Dou, Kaiyu Han, Mochao Xiao, Fuzhen Lv
MiR-223-5p has been demonstrated to regulate the development and progression of various cancers, such as hepatocellularcarcinoma, breast cancer and gastric carcinoma. However, the role of miR-223-5p in non-small cell lung cancer (NSCLC) requires further investigation. In this study, we found that the expression of miR-223-5p was significantly down-regulated in NSCLC tissues and cell lines. Moreover, the expression level of miR223-5p is negatively correlated with the malignance of NSCLC. Besides, we found that overexpression of miR-223-5p remarkably suppressed the proliferation of NSCLC cells in vitro and in vivo ...
April 3, 2018: Oncology Research
https://www.readbyqxmd.com/read/29615146/curcumin-suppress-the-growth-of-hepatocellular-carcinoma-via-down-regulating-srebf1
#17
Zhen You, Bei Li, Jingchang Xu, Liping Chen, Hui Ye
The aim of this study is to investigate the pharmacological effect of curcumin on hepatocellular carcinoma (HCC) Huh7 and PLC cells and to explore its mechanism in the pathological process by screening possible target genes. MTT assay was used to detect the effect of curcumin on the growth of Huh7 and PLC cells. The inhibitory effect was found to be in a time- and dose- dependent manner, and the cytoplasm was shrunk with round or elliptic morphology. Flow cytometry indicated that curcumin could significantly accelerate apoptosis of Huh7 and PLC cells, showing an obvious dosage effect...
April 3, 2018: Oncology Research
https://www.readbyqxmd.com/read/29562961/kinesin-motor-protein-kifc1-is-a-target-protein-of-mir-338-3p-and-associated-with-poor-prognosis-and-progression-of-renal-cell-carcinoma
#18
Gang Li, Tie Chong, Jie Yang, Hongliang Li, Haiwen Chen
KIFC1 (kinesin motor) plays a critical role in clustering of extra centrosomes in various cancer cells and thus to be considered as a promising therapeutic target. However, whether KIFC1 is involved in the procession of renal cell carcinoma (RCC) still remains unclear. In this study, we found that KIFC1 was upregulated in RCC tissues and responsible for RCC tumorigenesis (P < 0.001). The high expression of KIFC1 correlates with aggressive clinicopathologic parameters. Kaplan-Meier analysis suggested that KIFC1 was associated with poor survival prognosis in RCC...
March 21, 2018: Oncology Research
https://www.readbyqxmd.com/read/29562960/mir-632-promotes-laryngeal-carcinoma-cell-proliferation-migration-and-invasion-through-negative-regulation-of-gsk3%C3%AE
#19
Zhong-Xin Zhou, Zu-Ping Zhang, Ze-Zhang Tao, Ting-Zhao Tan
Laryngeal cancer, one of the most common head and neck malignancies, is an aggressive neoplasm. Increasing evidence hasdemonstrated that microRNAs (miRNAs) exert important roles in oncogenesis and progression of diverse types of human cancers. MiR-632, a tumor-related miRNA, has been reported to be dysregulated and implicated in human malignancies; however, its biological role in laryngeal carcinoma remains to be elucidated. The present study aimed at exploring the role of miR-632 in laryngeal cancer and clarifying the potential molecular mechanisms involved...
March 21, 2018: Oncology Research
https://www.readbyqxmd.com/read/29562959/microrna-615-3p-inhibits-the-tumor-growth-and-metastasis-of-nsclc-via-inhibiting-igf2
#20
Jiangtao Liu, Yanli Jia, Lijuan Jia, Tingting Li, Lei Yang, Gongwen Zhang
MicroRNAs are essential regulators of cancer-associated gene at the post-transcriptional level and their expression isaltered in cancer tissues. Herein, we sought to identify the regulation of miR-615-3p in NSCLC progression and its mechanism. MiR-615-3p expression was significantly down-expression in NSCLC tissue than that in control normal tissue. Exogenous over-expression of miR-615-3p inhibited the growth and metastasis of NSCLC cells. In addition, the in vivo mouse xenograft model showed that over-expression of miR615-3p inhibited NSCLC growth and lung metastasis whereas down-expression of miR-615-3p caused an opposite outcome...
March 21, 2018: Oncology Research
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