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Journal of Assisted Reproduction and Genetics

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October 13, 2018: Journal of Assisted Reproduction and Genetics
Anthea B M Paul, Seifeldin T Sadek, Arnold M Mahesan
MicroRNAs (miRNAs) are emerging as important in human embryo implantation, and we present here a review of the literature from a clinical perspective. Implantation involves complex interactions between the blastocyst and endometrium. miRNAs have been shown to be differentially expressed in implanted compared with non-implanted blastocysts and euploid compared with aneuploid blastocysts. Further, miRNAs are differentially expressed in proliferative compared with decidualized endometrium, and in receptive compared with pre-receptive endometrium...
October 12, 2018: Journal of Assisted Reproduction and Genetics
Sujith Raj Salian, Guruprasad Nayak, Sandhya Kumari, Sandesh Patel, Shruthi Gowda, Yashaswini Shenoy, Sinoy Sugunan, Rajanikant G K, Renuka Suresh Managuli, Srinivas Mutalik, Vandana Dahiya, Samanwita Pal, Satish Kumar Adiga, Guruprasad Kalthur
PURPOSE: Motility of spermatozoa helps not only in planning the type of infertility treatment but also directly reflects the success rate in assisted reproductive technology (ART). Previously, biotin, a water-soluble vitamin, has been shown to increase the motility and longevity of cryopreserved human spermatozoa. The present study was designed to understand the molecular basis of the beneficial effects of presence of biotin in sperm wash medium on early embryo development. METHODS: The effect biotin supplementation to sperm wash medium on the sperm parameters were assessed in swim-up fraction of normozoospermic and asthenozoospermic ejaculates collected from infertile men...
October 4, 2018: Journal of Assisted Reproduction and Genetics
Yelena Dondik, Zhenmin Lei, Jeremy Gaskins, Kelly Pagidas
PURPOSE: DNA repair genes Minichromosome maintenance complex component (MCM) 8 and 9 have been linked with gonadal development, primary ovarian insufficiency (POI), and age at menopause. Our objective was to characterize MCM 8 and 9 gene expression in the menstrual cycle, and to compare MCM 8/9 expression in POI vs normo-ovulatory women. METHODS: Normo-ovulatory controls (n = 11) and unexplained POI subjects (n = 6) were recruited. Controls provided three blood samples within one menstrual cycle: (1) early follicular phase, (2) ovulation, and (3) mid-luteal phase...
October 1, 2018: Journal of Assisted Reproduction and Genetics
Maria Eduarda Bonavides Amaral, Dani Ejzenberg, Denis Schapira Wajman, Pedro Augusto Araújo Monteleone, Paulo Serafini, Jose Maria Soares, Edmund Chada Baracat
PURPOSE: Controlled ovarian stimulation is a fundamental part of a successful assisted reproduction treatment, and recognizing patients at risk of a poor response allows the development of targeted research to propose new treatment strategies for this specific group. The objective of this systematic review was to determine risk factors for poor ovarian response (POR) to controlled stimulation in assisted reproduction cycles described in the literature. METHODS: The primary databases MEDLINE, Cochrane, LILACS, and SciELO were consulted, using specific terms with a restriction for articles in English or Portuguese published in the last 10 years...
September 29, 2018: Journal of Assisted Reproduction and Genetics
Roohi Jeelani, Gretchen G Collins, Angeline Beltsos, William G Kearns
Conferences serve an essential means of learning and staying up to date in all aspects of medicine. Reproductive endocrinology and infertility is a young and constantly evolving field. The Midwest Reproductive Symposium International (MRSi) is a yearly conference held in Chicago, IL, and is one of the most intimate yet influential conferences in the fertility world. This conference is geared towards all professions and roles in the fertility world such as physicians, geneticists, nurses, allied health professionals, basic scientists, mental health professionals, business administration professionals, reproductive endocrinology and infertility fellows, and obstetrics and gynecology residents alike...
September 27, 2018: Journal of Assisted Reproduction and Genetics
Ozlem Okutman, Maroua Ben Rhouma, Moncef Benkhalifa, Jean Muller, Stéphane Viville
PURPOSE: This review provides an update on the genetics of male infertility with emphasis on the current state of research, the genetic disorders that can lead to non-syndromic male infertility, and the genetic tests available for patients. METHODS: A comprehensive review of the scientific literature referenced in PubMed was conducted using keywords related to male infertility and genetics. The search included articles with English abstracts appearing online after 2000...
September 26, 2018: Journal of Assisted Reproduction and Genetics
Sherman J Silber, Michael DeRosa, Sierra Goldsmith, Yuting Fan, Leilani Castleman, Jeffrey Melnick
PURPOSE: To report the results of cryopreserved ovary tissue transplantation for leukemia and other cancers, in a single US center. METHODS: One hundred eight females between age 6 and (median age 24) 35 were referred for possible ovary tissue cryopreservation over a 20-year period, with either slow freeze or vitrification. Thus far 13 patients returned up to 18 years later to have their tissue transplanted back. RESULTS: All 13 patients had return of ovarian function 5 months post transplant with regular menstrual cycling...
September 25, 2018: Journal of Assisted Reproduction and Genetics
Lei Zhang, Daimin Wei, Yueting Zhu, Yuan Gao, Junhao Yan, Zi-Jiang Chen
PURPOSE: Mosaicism is a prevalent characteristic of human preimplantation embryos. This retrospective cohort study aimed to investigate pregnancy outcomes after transfer of mosaic or euploid embryos. METHODS: The embryos, which had been transferred as "euploidy," were processed using array-based comparative genomic hybridization (aCGH). The original aCGH charts of the transferred embryos were reanalyzed. Mosaic and control euploid embryos were defined according to log2 ratio calls...
September 24, 2018: Journal of Assisted Reproduction and Genetics
Francesca E Duncan, Raquel Romar, Joaquín Gadea, Dana Kimelman, Harlan D Wallach, Teresa K Woodruff, Maria Jiménez-Movilla
PURPOSE: Scientific literacy and communication are critical skills in the biological sciences. Journal clubs, in which peer-reviewed academic literature is discussed, are traditionally used to teach students to evaluate the literature, review scientific findings, and learn about historical, controversial, or current topics. METHODS: We used a virtual journal club to facilitate the international interaction between two universities with master's degree programs in the reproductive sciences: the University of Murcia (Spain) and Northwestern University (USA)...
September 24, 2018: Journal of Assisted Reproduction and Genetics
A Galvão, I Segers, J Smitz, H Tournaye, Michel De Vos
PURPOSE: To assess the efficiency of IVM in patients with repeated ART failure due to resistant ovary syndrome or due to deficient oocyte maturation. METHODS: Clinical and laboratory data were obtained retrospectively from 28 patients who underwent 49 cycles of IVM between 2010 and 2017; nine patients had resistant ovary syndrome and 19 patients had repeated deficient oocyte maturation. RESULTS: Nine patients with resistant ovary syndrome underwent 24 IVM cycles...
September 20, 2018: Journal of Assisted Reproduction and Genetics
I Lindgren, H Nenonen, E Henic, L Bungum, A Prahl, M Bungum, I Leijonhufvud, I Huhtaniemi, C Yding Andersen, Y Lundberg Giwercman
PURPOSE: The objective was to investigate if the gonadotropin receptor variants N680S (N: asparagine, S: serine, rs6166) in the follicle-stimulating hormone receptor (FSHR) and N312S (rs2293275) in the luteinizing hormone/human chorionic gonadotropin receptor (LHCGR) predicted cumulative live birth rate after in vitro fertilization (IVF). METHODS: A total of 665 women were consecutively enrolled for IVF during the period 2007-2016. Inclusion criteria were < 40 years of age, body mass index < 30 kg/m2 , non-smoking, regular menstruation cycle of 21-35 days, and bilateral ovaries...
September 19, 2018: Journal of Assisted Reproduction and Genetics
A G Grynnerup, M Toftager, A Zedeler, J W Bogstad, L Prætorius, M L Grøndahl, C Yding Andersen, S Sørensen, A Pinborg, K Løssl
PURPOSE: Investigating whether pre-ovulatory follicular fluid (FF) levels of selected proteins differ between women who do or do not develop severe ovarian hyperstimulation syndrome (OHSS) and evaluate whether they potentially could guide a "freeze-all" strategy. METHODS: FF was collected during a randomized controlled trial comparing OHSS in antagonist versus agonist protocol including 1050 women in their first assisted reproductive technology (ART) cycle during year 2009-2013...
September 19, 2018: Journal of Assisted Reproduction and Genetics
Wilder Hernando Ortiz Vega, Celia Raquel Quirino, Aylton Bartholazzi-Junior, Miguel Alejandro Silva Rua, Raquel Varella Serapião, Clara Slade Oliveira
PURPOSE: This study aimed to associate DNA variants in promoter and exon flanking regions of the CYP19A1 gene with in vitro embryo production traits in cattle. The role of transcription factor binding sites created or lost due to DNA sequence variation and their possible effect on gene expression was also evaluated. METHODS: We collected date from Gyr dairy oocyte donor cows (Bos taurus indicus) at a commercial in vitro embryo production farm and analyzed the genotype-phenotype association with in vitro production traits...
September 19, 2018: Journal of Assisted Reproduction and Genetics
M C Schiewe, M Freeman, J B Whitney, M D VerMilyea, A Jones, M Aguirre, C Leisinger, G Adaniya, N Synder, R Chilton, E J Behnke
Recent publicized events of cryogenic storage tank failures have created nationwide concern among infertility patients and patients storing embryos and gametes for future use. To assure patient confidence, quality management (QM) plans applied by in vitro fertilization (IVF) laboratories need to include a more comprehensive focus on the cryostorage of reproductive specimens. The purpose of this review is to provide best practice guidelines for the cryogenic storage of sperm, oocytes, embryos, and other reproductive tissues (e...
September 19, 2018: Journal of Assisted Reproduction and Genetics
Jigal Haas, Jim Meriano, Rawad Bassil, Eran Barzilay, Robert F Casper
PURPOSE: A few years ago, we started to use a new freeze-thaw protocol for the frozen embryo transfer cycles. Instead of thawing the embryos 2-4 h prior to the transfer, we started thawing the embryos 20-22 h prior to the transfer. The aim of this study was to compare the pregnancy rate in cases of embryos that continued to develop in the post-thawing culture to that of embryos that did not. METHODS: A retrospective cohort study of blastocyst freeze/thaw cycles vitrified on day 5, thawed and transferred after 20-22 h in the culture, between January 2012 and December 2016...
September 19, 2018: Journal of Assisted Reproduction and Genetics
Haimei Qin, Rong Wang, Xiaoxia Pang, Yuxiao Wei, Fenglian Yang, Junli Wang
PURPOSE: The aim of this study was undertaken to investigate the association of 78-kDa glucose-regulated protein (GRP78) gene promoter polymorphisms with risk of asthenozoospermia (AZS) men. In addition, we performed association analysis between GRP78 promoter mutations and serum GRP78 level in asthenozoospermia. METHODS: The study population comprised 400 subjects with AZS patients and 400 healthy controls. We assessed GRP78 rs3216733, rs17840761, and rs17840762 polymorphisms by using Snapshot SNP genotyping assays; serum GRP78 level was measured by enzyme-linked immunosorbent assay (ELISA)...
September 18, 2018: Journal of Assisted Reproduction and Genetics
Zaida Sarrate, Mireia Solé, Francesca Vidal, Ester Anton, Joan Blanco
The production of functional spermatozoa through spermatogenesis requires a spatially and temporally highly regulated gene expression pattern, which in case of alterations, leads to male infertility. Changes of gene expression by chromosome anomalies, gene variants, and epigenetic alterations have been described as the main genetic causes of male infertility. Recent molecular and cytogenetic approaches have revealed that higher order chromosome positioning is essential for basic genome functions, including gene expression...
September 18, 2018: Journal of Assisted Reproduction and Genetics
Fabiana M Kreines, Dimitrios Nasioudis, Evelyn Minis, Mohamad Irani, Steven S Witkin, Steven Spandorfer
PURPOSE: Retrospective cohort studies have shown a relationship between maternal serum interleukin-1β (IL-1β) and interleukin-1 receptor antagonist (IL-1Ra) levels and in vitro fertilization (IVF) cycle outcome. The objective of this investigation was to explore the correlation between serum IL-1β and/or IL-1Ra levels obtained prospectively and IVF outcomes. METHODS: Sera from 205 women were collected just prior to initiation of their IVF cycle, at the time of human chorionic gonadotropin administration, day 24 of IVF cycle, day 28, and day 35...
September 17, 2018: Journal of Assisted Reproduction and Genetics
Mercedes González Martínez, Pascual Sánchez-Martín, Mónica Dorado-Silva, José Luís Fernández, Estibaliz Girones, Stephen D Johnston, Jaime Gosálvez
PURPOSE: To determine whether there is a homogeneous reduction of sperm DNA fragmentation (SDF) in sperm samples recovered from the MACS procedure, compared to spermatozoa in the initial ejaculate (NEAT) and those retained in the column. METHODS: This study investigated the relative change in sperm DNA quality (SDF) of neat ejaculates (10 idiopathic infertile and 10 normozoospermic patients) to subpopulations of spermatozoa that had passed through the column (MACS-) and those retained (MACS+) by the annexin-V conjugated microbeads...
September 17, 2018: Journal of Assisted Reproduction and Genetics
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