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Journal of Assisted Reproduction and Genetics

V E Klenov, S L Boulet, R B Mejia, D M Kissin, E Munch, A Mancuso, B J Van Voorhis
OBJECTIVE: To compare live birth rates (LBRs) and multiple birth rates (MBRs) between elective single-embryo transfer (eSET) and double-embryo transfer (DET) in donor oocyte in vitro fertilization (IVF) treatments in both a cycle-level and clinic-level analysis. METHODS: Donor oocyte IVF treatments performed by US IVF clinics reporting to the Centers for Disease Control and Prevention in 2013-2014 were included in the analysis. Primary outcomes included LBR and MBR...
June 21, 2018: Journal of Assisted Reproduction and Genetics
Carol Sukhn, Johnny Awwad, Akram Ghantous, Ghazi Zaatari
BACKGROUND: Human exposure to environmental pollutants is widespread. It was suggested that exposure to non-essential heavy metals may adversely affect semen development in men. PURPOSE: To evaluate associations between non-essential heavy metals in blood and seminal fluid and semen quality parameters in men. METHODS: Male partners of heterosexual couples were included. The following elements were measured in blood and seminal fluid: lead (Pb), cadmium (Cd), arsenic (As), barium (Ba), mercury (Hg), and uranium (U) using ion-coupled plasma-mass spectrometry...
June 21, 2018: Journal of Assisted Reproduction and Genetics
A M Mahesan, S Sadek, V Moussavi, T Vazifedan, A Majeed, T Cunningham, S Oehninger, S Bocca
PURPOSE: The aims of this study were (1) to evaluate clinical outcomes after ICSI cycles using surgically recovered sperm and (2) to assess the influence of maternal age on those outcomes. METHODS: A retrospective cohort study of 24,763 IVF cycles of fresh autologous oocytes and ICSI using surgically recovered sperm reported to the SART CORS database from 2004 to 2015. RESULTS AND CONCLUSIONS: Older women had significantly longer stimulation (p < 0...
June 20, 2018: Journal of Assisted Reproduction and Genetics
Ruiqi Li, Songbang Ou, Nengyong Ouyang, Lingyan Zheng, Qingxue Zhang, Dongzi Yang, Wenjun Wang
PURPOSE: The objective of this study was to determine whether ammonium accumulates in IVF media during fertility process and whether the brief co-incubation of gametes (bIVF) benefited the outcomes of newborns. METHODS: Ammonium levels in IVF media during gamete co-incubation were measured and the effects of bIVF on neonatal outcomes were evaluated retrospectively in this study. RESULTS: A total of 609 live newborns cycles were included in this study...
June 20, 2018: Journal of Assisted Reproduction and Genetics
Judy E Stern, Chia-Ling Liu, Howard J Cabral, Elliott G Richards, Charles C Coddington, Sunah Hwang, Dmitry Dukhovny, Hafsatou Diop, Stacey A Missmer
PURPOSE: To determine whether differences in birth outcomes among assisted reproductive technology (ART)-treated, subfertile, and fertile women exist in primiparous women with, singleton, vaginal deliveries. METHODS: Society for Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) data were linked to Massachusetts vital records and hospital discharges for deliveries between July 2004 and December 2010. Primiparous women with in-state vaginal deliveries, adequate prenatal care, and singleton birth at ≥ 20 weeks (n = 117,779) were classified as ART-treated (linked to ART data from SART CORS, n = 3138); subfertile (not ART-treated but with indicators of subfertility, n = 1507); or fertile (neither ART-treated nor subfertile, n = 113,134)...
June 20, 2018: Journal of Assisted Reproduction and Genetics
Stephanie L F Gustin, Guangwen Wang, Valerie M Baker, Gary Latham, Vittorio Sebastiano
OBJECTIVE: Create a model, using reprogrammed cells, to provide a platform to identify the mechanisms of CGG repeat instability amongst female fragile X mental retardation 1 gene (FMR1) premutation (PM) carriers. METHODS: Female PM carriers (with and without POI) and healthy controls were enrolled from June 2013 to April 2014. Patient-derived fibroblasts (FB) were reprogrammed to induced pluripotent stem cells (iPSC) using viral vectors, encoding KLF4, OCT4, SOX2, and MYC...
June 20, 2018: Journal of Assisted Reproduction and Genetics
M Feichtinger, A Reiner, B Hartmann, T Philipp
PURPOSE: The aim of the study was to assess cytogenetic and embryoscopic characteristics in subsequent miscarriages of spontaneous pregnancy losses (SPL) and recurrent pregnancy losses (RPL). METHODS: A retrospective cohort of 75 women was affected by repeated pregnancy loss. Of those, 34 had SPL, 24 primary RPL, and 17 secondary RPL. Ploidy status and morphology was analyzed by transcervical embryoscopic examination of the embryo and cytogenetic analysis of the chorionic villi in subsequent miscarriages...
June 18, 2018: Journal of Assisted Reproduction and Genetics
K J Juárez-Rendón, J E García-Ortiz
PURPOSE: Primary ovarian insufficiency (POI) is a clinical condition observed in women younger than 40 years of age, characterized by amenorrhea, hypoestrogenism, high levels of follicle-stimulating hormone (FSH), and infertility. Mutations in some master regulators of the development, maturation, and maintenance of ovarian follicles such as BMP15, FSHR, FOXL2, and GDF9 have been suggested as etiological factors in the development of POI. The aim of this study, the first in the Mexican population, is to evaluate the presence of mutations or polymorphisms in these four candidate genes...
June 18, 2018: Journal of Assisted Reproduction and Genetics
Elizabeth E Puscheck, Alan Bolnick, Awoniyi Awonuga, Yu Yang, Mohammed Abdulhasan, Quanwen Li, Eric Secor, Erica Louden, Maik Hüttemann, Daniel A Rappolee
Here we examine recent evidence suggesting that many drugs and diet supplements (DS), experimental AMP-activated protein kinase (AMPK) agonists as well as energy-depleting stress, lead to decreases in anabolism, growth or proliferation, and potency of cultured oocytes, embryos, and stem cells in an AMPK-dependent manner. Surprising data for DS and drugs that have some activity as AMPK agonists in in vitro experiments show possible toxicity. This needs to be balanced against a preponderance of evidence in vivo that these drugs and DS are beneficial for reproduction...
June 7, 2018: Journal of Assisted Reproduction and Genetics
Edouard J Servy, Laetitia Jacquesson-Fournols, Marc Cohen, Yves J R Menezo
PURPOSE: To evaluate the possibility of correcting metabolic defects in gametes and embryos due to methylene tetra hydrofolate reductase (MTHFR) isoforms C677T and A1298C, by supplementation with 5-methyl THF instead of synthetic folic acid. In these couples, high doses of folic acid lead to UMFA (un-metabolized folic acid) syndrome. METHODS: Thirty couples with fertility problems lasting for at least 4 years, such as recurrent fetal loss, premature ovarian insufficiency, or abnormal sperm parameters, with two thirds of them having failed assisted reproductive technology (ART) attempts were included in this program...
June 7, 2018: Journal of Assisted Reproduction and Genetics
Avner Hershlag, Sara L Bristow
The rapid development of gene-editing technologies has led to an exponential rise in both basic and translational research initiatives studying molecular processes and investigating possible clinical applications. Early experiments using genome editing to study human embryo development have contradicted findings in studies on model organisms. Additionally, a series of four experiments over the past 2 years set out to investigate the possibilities of introducing genetic modifications to human embryos, each with varying levels of success...
June 7, 2018: Journal of Assisted Reproduction and Genetics
Zhichao Li, Ruihuan Gu, Xiaowei Lu, Shen Zhao, Yun Feng, Yijuan Sun
PURPOSE: Oocyte vitrification is currently used for human fertility preservation. However, vitrification damage is a problem caused by decreasing ooplasmic levels of glutathione (GSH). The GSH donor glutathione ethyl ester (GSH-OEt) can significantly increase the GSH content in oocytes. However, it is difficult to obtain oocyte from woman. To overcome this, we used mouse oocytes to replace human oocytes as a model of study. METHODS: Oocytes from B6D2F1 mice were preincubated for 30 min with 2...
June 6, 2018: Journal of Assisted Reproduction and Genetics
L Zakarin Safier, A Gumer, M Kline, D Egli, M V Sauer
PURPOSE: Human oocytes are arguably one of the most important cell types in humans, yet they are one of the least investigated cells. Because oocytes are limited in number, the use of high-quality oocytes is almost entirely in reproduction. Furthermore, regulatory hurdles for research on gametes and regulations on funding related to research on gametes present significant obstacles to research and the advancement of reproductive treatments. Here we report the outcomes of the largest compensated oocyte donation program for research in the USA to date, and probably worldwide...
June 5, 2018: Journal of Assisted Reproduction and Genetics
M von Wolff, T Bruckner, T Strowitzki, A Germeyer
PURPOSE: To study if ovarian response is affected by the type of disease if fertility preservation is required. METHODS: A registry of the trinational fertility preservation network FertiPROTEKT including 992 patients aged 18-40 years undergoing ovarian stimulation and follicle aspiration for fertility preservation from 1/2007 until 3/2016 was analysed. The number of collected oocytes, days of stimulation, total gonadotropin dosage and gonadotropin dosage per day were evaluated...
June 5, 2018: Journal of Assisted Reproduction and Genetics
Yoni Cohen, Alexandra St-Onge-St-Hilaire, Samer Tannus, Grace Younes, Michael H Dahan, William Buckett, Weon-Young Son
PURPOSE: To assess effects on fertilization rate, embryo quality, pregnancy, and live birth rates of vitrification and warming of oocytes that matured in vitro (vIVM) compared to fresh in vitro maturation (fIVM) cycles. METHODS: A retrospective cohort study conducted at a university hospital-affiliated IVF unit. Fifty-six cycles of vIVM cycles and 263 fIVM in women diagnosed with polycystic ovarian syndrome (PCOS) ovaries were included in the analysis. The study group included PCOS patients who failed ovulation induction with intrauterine insemination and were offered IVM cycle followed by oocyte vitrification and warming...
June 4, 2018: Journal of Assisted Reproduction and Genetics
Haiyan Lin, Yu Li, Weijie Xing, Qi Qiu, Wenjun Wang, Qingxue Zhang
OBJECTIVE: To screen differentially expressed lncRNAs involved in OHSS. OHSS is defined as ovarian hyperstimulation syndrome. It is characterized as enlarged ovary and increased vascular permeability. DESIGN: Case-control study. SETTING: University-affiliated hospital. PATIENT(S): Patients with OHSS high risk (n = 30) and low risk (n = 30) were included in this study. INTERVENTION(S): None...
June 4, 2018: Journal of Assisted Reproduction and Genetics
Kiersten Rule, Renee J Chosed, T Arthur Chang, J David Wininger, William E Roudebush
PURPOSE: Cell-free DNA (cfDNA) which is present in the blastocoel cavity of embryos is believed to result from physiological apoptosis during development. This study assessed cfDNA content and caspase-3 protease activity in day-5 IVF blastocysts to determine if there was a correlation with embryo morphology. METHODS: Day-5 IVF blastocysts were scored according to the Gardner and Schoolcraft system (modified to generate a numerical value) and cfDNA was collected following laser-induced blastocoel collapsing prior to cryopreservation in 25 μL of media...
June 4, 2018: Journal of Assisted Reproduction and Genetics
Dikea Roussos-Ross, Alice S Rhoton-Vlasak, Katherine M Baker, Brittany J Arkerson, Georgia Graham
The inability to conceive is an immensely stressful event in a woman's life. Thus, it is no surprise that women with infertility have twice the rates of depressive symptoms as women without infertility. Incidence of depression in the general female population is approximately 20% compared to almost 40% in infertile females. Based on this information, we expect many individuals with infertility to have pre-existing mood disorders requiring ongoing treatment. In addition, we expect a subset of women to develop a mood disorder during infertility treatment due to related stressors...
June 2, 2018: Journal of Assisted Reproduction and Genetics
Ming-Tzeung Chung, Chii-Ruey Tzeng, Ching-Hui Chen, Cindy Chan, Yi-En Chang, Yi-Hua Wu, Chi-Huang Chen
No abstract text is available yet for this article.
June 2, 2018: Journal of Assisted Reproduction and Genetics
Mona K Mekkawy, Ahmed M El Guindi, Inas M Mazen, Alaaeldin G Fayez, Amal M Mohamed, Alaa K Kamel
No abstract text is available yet for this article.
June 2, 2018: Journal of Assisted Reproduction and Genetics
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