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Journal of Assisted Reproduction and Genetics

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https://www.readbyqxmd.com/read/29435699/psychosocial-benefits-of-fertility-preservation-for-young-cancer-patients
#1
Juliana Assi, Juliana Santos, Tatiana Bonetti, Paulo C Serafini, Eduardo L A Motta, Mauricio Barbour Chehin
PURPOSE: The risk of ovarian failure after radiotherapy and/or chemotherapy is a concern among oncologic women. There is no doubt regarding the psycho-emotional benefits of fertility preservation (FP) after a cancer diagnosis because concerns about biological conception are a source of anxiety and can even affect the patient's cancer recovery. The aim of this study was to evaluate oncology patients' feelings, concerns, and life quality impacts related to FP. METHODS: This qualitative cross-sectional study was based on a questionnaire administered to a selected group of women diagnosed with cancer who underwent FP...
February 12, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29423789/do-trained-reproductive-endocrinologists-perform-better-than-their-trainees-comparing-clinical-pregnancy-rates-and-live-birth-rates-after-transfer-of-single-fresh-blastocysts
#2
Sadikah Behbehani, Joseph Hasson, Stefano Polesello, W Y Son, Togas Tulandi, William Buckett
PURPOSE: To compare clinical pregnancy rates and live birth rates of single blastocyst transfers performed by attending physicians or fellows in reproductive endocrinology and infertility program. METHODS: Retrospective study in an academic reproductive center. We evaluated 932 fresh single blastocyst transfer cycles performed by fellows in training (389 embryo transfers) and by attending physicians (543 embryo transfers). RESULTS: There were no differences in the baseline characteristics and IVF cycle parameters between patients who had transfers performed by fellows or attending physicians...
February 9, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29423788/evaluation-of-extraction-methods-for-methylated-cell-free-fetal-dna-from-maternal-plasma
#3
Ji Hyae Lim, Bom Yi Lee, Jin Woo Kim, You Jung Han, Jin Hoon Chung, Min Hyoung Kim, Dong Wook Kwak, So Yeon Park, Hee Back Choi, Hyun Mee Ryu
PURPOSE: Recently, fetal placenta-specific epigenetic regions (FSERs) have been identified for quantification of cell-free fetal DNA (cff-DNA) for non-invasive prenatal testing (NIPT). The aim of this study was to evaluate the efficiencies of a column-based kit and magnetic bead-based kit for quantification of methylated FSERs from maternal plasma. METHODS: Maternal plasma was extracted from normal pregnant women within the gestational age of 10~13 weeks (n = 24)...
February 8, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29417303/pseudohypoparathyroidism-type-1b-in-a-patient-conceived-by-in-vitro-fertilization-another-imprinting-disorder-reported-with-assisted-reproductive-technology
#4
REVIEW
Nicholas J Goel, Laura L Meyers, Myrto Frangos
Pseudohypoparathyroidism type 1B (PHP1B) is characterized by renal tubular resistance to parathyroid hormone (PTH) leading to hyperphosphatemia, hypocalcemia, elevated PTH, and hyperparathyroid bone changes. PHP1B is an imprinting disorder that results from loss of methylation at the maternal GNAS gene, which suppresses transcription of the alpha subunit of the stimulatory G protein of the PTH receptor. Emerging evidence supports an association between assisted reproductive technologies (ART) and imprinting disorders; however, there is currently little evidence linking PHP1B and ART...
February 7, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29404863/in-vitro-evidence-that-platelet-rich-plasma-stimulates-cellular-processes-involved-in-endometrial-regeneration
#5
Lusine Aghajanova, Sahar Houshdaran, Shaina Balayan, Evelina Manvelyan, Juan C Irwin, Heather G Huddleston, Linda C Giudice
PURPOSE: The study aims to test the hypothesis that platelet-rich plasma (PRP) stimulates cellular processes involved in endometrial regeneration relevant to clinical management of poor endometrial growth or intrauterine scarring. METHODS: Human endometrial stromal fibroblasts (eSF), endometrial mesenchymal stem cells (eMSC), bone marrow-derived mesenchymal stem cells (BM-MSC), and Ishikawa endometrial adenocarcinoma cells (IC) were cultured with/without 5% activated (a) PRP, non-activated (na) PRP, aPPP (platelet-poor-plasma), and naPPP...
February 5, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29392516/ovarian-tissue-cryopreservation-otc-in-prepubertal-girls-and-young-women-an-analysis-of-parents-and-patients-decision-making
#6
Chantae S Sullivan-Pyke, Claire A Carlson, Maureen Prewitt, Clarisa R Gracia, Jill P Ginsberg
PURPOSE: The purpose of this study was to explore the decision-making influences, perceived level of control over decision-making, and mood states of parents and patients who were offered OTC prior to gonadotoxic therapy. METHODS: Parents and patients, at least 12 years old, who required gonadotoxic therapy and were offered OTC prior to therapy, were asked to complete questionnaires. Two validated instruments were also used: the Decision-Making Control Instrument (DMCI) and the Profile of Mood States (POMS)...
February 1, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29392515/obstetric-and-neonatal-outcome-following-icsi-with-assisted-oocyte-activation-by-calcium-ionophore-treatment
#7
Ileana Mateizel, Greta Verheyen, Hilde Van de Velde, Herman Tournaye, Florence Belva
PURPOSE: Calcium ionophore treatment is being used in assisted reproductive technology (ART) for cases with previous low fertilization rate or total absence of fertilization after insemination by intracytoplasmic sperm injection or when a specific indication such as globozoospermia is present. As this technique is more invasive and differs from the physiological process of fertilization, a thorough investigation of the health of the children born following this procedure is required. We intent to report the medical outcome of all children conceived following calcium ionophore treatment in our IVF center...
February 1, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29380280/a-novel-male-2-4-14-complex-chromosomal-translocation-with-normal-semen-parameters-but-100-embryonic-aneuploidy
#8
Jade Mas, Reem Sabouni, Silvina Bocca
We report a case of a couple with a history of six spontaneous miscarriages in which a novel complex chromosomal rearrangement was detected in the male partner who had a totally normal semen analysis. Preimplantation genetic testing of their embryos demonstrated 100% aneuploidy.
January 29, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29380279/whither-human-ivf-fertilisable-oocytes-selected-on-the-basis-of-follicular-temperature
#9
EDITORIAL
Ronald H F Hunter, Fernando López-Gatius
Bearing in mind specific parallels between cow and human ovarian physiology, as noted in the manuscript, we have measured whether the temperature in a pre-ovulatory follicle is cooler than that in adjacent tissues. Using a novel approach not requiring anaesthetics or surgical procedures, we found that follicular fluid bathing cow oocytes shortly before ovulation is cooler than the neighbouring uterine surface and cooler than deep rectal temperature (the reference body temperature in cattle). By contrast, Graafian follicles of comparable size and ultrasonic image that do not subsequently ovulate do not have a reduced antral temperature...
January 29, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29380278/intra-patient-variability-in-the-endometrial-receptivity-assay-era-test
#10
LETTER
Kristy Cho, SeangLin Tan, William Buckett, Michael H Dahan
No abstract text is available yet for this article.
January 29, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29380277/first-trimester-pregnancy-ultrasound-findings-as-a-function-of-method-of-conception-in-an-infertile-population
#11
Frauke von Versen-Höynck, Jenna S Petersen, Yueh-Yun Chi, Jing Liu, Valerie L Baker
PURPOSE: The aim of this study was to determine whether first trimester ultrasound measurements of crown rump length (CRL) and gestational sac diameter (GSD) differ depending on the method of conception among infertile women. METHOD: Infertile women, ages 21-50 years old, who conceived viable, singleton pregnancies via fresh embryo transfer (ET), frozen ET, non-in vitro fertilization (IVF) fertility treatment, or spontaneously were included in this observational cohort study at an academic fertility practice...
January 29, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29359264/characterization-of-a-complex-chromosomal-rearrangement-involving-chromosomes-1-3-and-4-in-a-slightly-affected-male-with-bad-obstetrics-history
#12
Pritti K Priya, Vineet V Mishra, Thomas Liehr, Monika Ziegler, Stuti Tiwari, Alpesh Patel, Shiva Shankar Chettiar, Hetvi Patel
No abstract text is available yet for this article.
January 23, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29357026/effect-of-mouse-ovarian-tissue-cryopreservation-by-vitrification-with-rapid-i-closed-system
#13
Naoki Okamoto, Mariko Nakajima, Yodo Sugishita, Nao Suzuki
PURPOSE: Currently, open systems are mainly used for cryopreservation of ovarian tissue, oocytes, and embryos, but there is a potential risk of contamination. This study was performed to assess ovarian tissue cryopreservation by a closed vitrification system (Rapid-i vitrification system™), which is already used clinically for oocyte/embryo cryopreservation. METHODS: Ovaries of C57BL/6J mice were frozen and thawed by using the Rapid-i vitrification system™ (Rapid-i) followed by implantation into recipient mice...
January 22, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29357025/a-higher-incidence-of-cleavage-failure-in-oocytes-containing-smooth-endoplasmic-reticulum-clusters
#14
Junko Otsuki, T Iwasaki, Y Katada, Y Tsutsumi, Y Tsuji, K Furuhashi, S Kokeguchi, M Shiotani
PURPOSE: In human oocytes, sERCs are one of the dysmorphic phenotypes that have been reported. Significantly reduced pregnancy rates and a comparatively higher number of abnormities in live births appear to be associated with the presence of sERCs in oocytes. However, some reports have shown that healthy babies can be born, without any reduced pregnancy rates, from oocytes observed to contain sERCs. Thus, the clinical and scientific significance of oocytes that harbor sERCs remains controversial...
January 22, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29353449/blastulation-timing-is-associated-with-differential-mitochondrial-content-in-euploid-embryos
#15
Jacqueline R Ho, Nabil Arrach, Katherine Rhodes-Long, Wael Salem, Lynda K McGinnis, Karine Chung, Kristin A Bendikson, Richard J Paulson, Ali Ahmady
PURPOSE: Preimplantation genetic screening (PGS) and assessment of mitochondrial content (MC) are current methods for selection of the best embryos for transfer. Studies suggest that time-lapse morphokinetics (TLM) may also be helpful for selecting embryos more likely to implant. In our study, we sought to examine the relationship between TLM parameters and MC to determine if they could be used adjunctively in embryo selection. We also examined the relationship between MC with ploidy and blastulation...
January 20, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29350315/revisiting-embryo-assisted-hatching-approaches-a-systematic-review-of-the-current-protocols
#16
REVIEW
Alessandra Alteri, Paola Viganò, Ahmad Abu Maizar, Luca Jovine, Elisa Giacomini, Patrizia Rubino
Zona pellucida (ZP) manipulation, termed "assisted hatching" (AH), has been introduced in order to favor embryo hatching and ultimately improve assisted reproductive technology success but with poor proofs of safety and biological plausibility. We herein provide a systematic review of clinical outcomes following the application of different methods of ZP manipulation on fresh or frozen/thawed embryos at different developmental stages in different groups of patients. Out of the 69 papers that compared the clinical outcomes deriving from hatched versus non-hatched embryos, only 11 considered blastocysts while the rest referred to cleavage stage embryos...
January 19, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29344810/dehydroepiandrosterone-dhea-supplementation-an-underappreciated-cause-of-premature-progesterone-elevation-detected-during-frozen-embryo-transfer
#17
Frank Shao-Ying Wu, Shao-Ping Weng, Meng-Shun Shen
No abstract text is available yet for this article.
January 18, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29335812/sperm-telomere-length-in-donor-samples-is-not-related-to-icsi-outcome
#18
Marc Torra-Massana, Montserrat Barragán, Emanuela Bellu, Rafael Oliva, Amelia Rodríguez, Rita Vassena
PURPOSE: Variations in sperm telomere length (STL) have been associated with altered sperm parameters, poor embryo quality, and lower pregnancy rates, but for normozoospermic men, STL relevance in IVF/ICSI is still uncertain. Moreover, in all studies reported so far, each man's STL was linked to the corresponding female partner characteristics. Here, we study STL in sperm donor samples, each used for up to 12 women, in order to isolate and determine the relationship between STL and reproductive outcomes...
January 16, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29333568/comparison-of-effects-of-thawing-entire-donor-sperm-vial-vs-partial-thawing-shaving-on-sperm-quality
#19
Micha Baum, Raoul Orvieto, Sapir Kon, Ronit Machtinger, Gil M Yerushalmi, Ariel Hourvitz
PURPOSE: Partial thawing of a vial of cryopreserved sperm (shaving) is sometimes applied as a measure to preserve sperm for further use, particularly in cases of very restricted sperm quantity. However, mechanical violence may disrupt the sperm-wall and lead to impaired in-vitro fertilization (IVF) outcomes. MATERIAL AND METHODS: In a retrospective case-control study at a tertiary, university-affiliated medical center, we compared the IVF/intracytoplasmic sperm injection (ICSI) outcomes of patients who used donor sperm following partial thawing (shaving) of the vial of cryopreserved sperm (n = 99) to a control group consisting of patients for whom the vial of sperm was completely thawed before use (n = 99)...
January 15, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29327111/the-role-of-the-endometrial-receptivity-array-era-in-patients-who-have-failed-euploid-embryo-transfers
#20
J Tan, A Kan, J Hitkari, B Taylor, N Tallon, G Warraich, A Yuzpe, G Nakhuda
PURPOSE: Endometrial receptivity issues represent a potential source of implantation failure. The aim of this study was to document our experience with the endometrial receptivity array (ERA) among patients with a history of euploid blastocyst implantation failure. We investigated whether the contribution of the endometrial factor could be identified with the ERA test and if actionable results can lead to improved outcomes. METHODS: A retrospective review was performed for 88 patients who underwent ERA testing between 2014 and 2017...
January 11, 2018: Journal of Assisted Reproduction and Genetics
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