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Journal of Assisted Reproduction and Genetics

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https://www.readbyqxmd.com/read/28197932/effect-of-gnrha-ovulation-trigger-dose-on-follicular-fluid-characteristics-and-granulosa-cell-gene-expression-profiles
#1
Thi Ngoc Lan Vuong, M T Ho, T Q Ha, M Brehm Jensen, C Yding Andersen, P Humaidan
PURPOSE: A recent dose-finding study showed no significant differences in number of mature oocytes, embryos and top-quality embryos when triptorelin doses of 0.2, 0.3 or 0.4 mg were used to trigger final oocyte maturation in oocyte donors co-treated with a gonadotropin-releasing hormone (GnRH) antagonist. This analysis investigated whether triptorelin dosing for triggering final oocyte maturation in oocyte donors induced differences in follicular fluid (FF) hormone levels and granulosa cell gene expression...
February 14, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28190215/morbid-obesity-and-pregnancy-outcomes-after-single-blastocyst-transfer-a-retrospective-north-american-study
#2
Miguel Russo, Senem Ates, Talya Shaulov, Michael H Dahan
PURPOSE: Maternal obesity has been shown to affect reproductive function and pregnancy outcomes following in vitro fertilization. More recently, studies have demonstrated lower live birth rates after single blastocyst transfer (SBT) in patients who are overweight or obese. However, the impact of morbid obesity on pregnancy outcomes after SBT has not been well elucidated. The present study aimed to determine whether morbid obesity has a detrimental impact on pregnancy outcomes after SBT in a North American population...
February 11, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28190214/polar-body-transfer-restores-the-developmental-potential-of-oocytes-to-blastocyst-stage-in-a-case-of-repeated-embryo-fragmentation
#3
Shuo-Ping Zhang, Chang-Fu Lu, Fei Gong, Ping-Yuan Xie, Liang Hu, Shun-Ji Zhang, Guang-Xiu Lu, Ge Lin
PURPOSE: We aimed to determine the developmental potential of human reconstructed oocytes after polar body genome transfer (PBT) and to report the case of a woman with multiple cycles of severe embryo fragmentation. METHODS: Fresh and cryopreserved first polar bodies (PB1s) were transferred to enucleated metaphase II oocytes (PB1T), while fresh PB2s were removed from fertilized oocytes and used instead of the female pronucleus in donor zygotes. Reconstructed oocytes underwent intracytoplasmic sperm injection (ICSI) and were cultured to blastocyst...
February 11, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28190213/quantitative-and-qualitative-changes-of-mitochondria-in-human-preimplantation-embryos
#4
Shu Hashimoto, Naoharu Morimoto, Masaya Yamanaka, Hiroshi Matsumoto, Takayuki Yamochi, Hiroya Goto, Masayasu Inoue, Yoshiharu Nakaoka, Hiroaki Shibahara, Yoshiharu Morimoto
PURPOSE: The oxygen consumption rates (OCRs) in mice and cattle have been reported to change during preimplantation embryogenesis. On the other hand, mitochondrial DNA (mtDNA) copy number has been shown to be unchanged in mice and changed in cattle and pigs. The interactions between mitochondrial functions and mtDNA copy numbers in human embryos during preimplantation development remain obscure. METHODS: Sixteen oocytes and 100 embryos were used to assess mtDNA copy numbers and OCR...
February 11, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28190212/outcomes-of-medical-malpractice-claims-in-assisted-reproductive-technology-over-a-10-year-period-from-a-single-carrier
#5
Gerard Letterie
OBJECTIVE: Medical malpractice claims vary by specialty. Contributory factors to malpractice in reproductive endocrinology and infertility (REI) are not well defined. We sought to determine claims' frequency, basis of claims, and outcomes of settled claims in REI. DESIGN: This is a retrospective, descriptive review of 10 years of claims. SETTING: The setting is private practices. MATERIALS AND METHODS: Claims were monitored within one malpractice carrier between 2006 and 2015 covering 10 practices and 184,015 IVF cycles...
February 11, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28188594/extracellular-micrornas-in-follicular-fluid-and-their-potential-association-with-oocyte-fertilization-and-embryo-quality-an-exploratory-study
#6
Ronit Machtinger, Rodosthenis S Rodosthenous, Michal Adir, Abdallah Mansour, Catherine Racowsky, Andrea A Baccarelli, Russ Hauser
PURPOSE: The purpose of this study is to determine the profile of extracellular microRNAs (exmiRNAs) in follicular fluid (FF) and explore their association with fertilization potential and embryo quality. METHODS: We collected FF from single follicles containing mature oocytes from 40 women undergoing IVF and we screened for the expression of 754 exmiRNAs in FF using the TaqMan OpenArray® qPCR platform. To determine the association of exmiRNAs and IVF outcomes, we compared their expression levels in FF samples that differ by fertilization status (normally, abnormally, and failed to fertilize) and embryo quality (top vs...
February 10, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28188593/re-analysis-of-aneuploidy-blastocysts-with-an-inner-cell-mass-and-different-regional-trophectoderm-cells
#7
Jin Huang, Liying Yan, Sijia Lu, Nan Zhao, Jie Qiao
PURPOSE: The purpose of this study is to explore which part of the trophectoderm best represents the inner cell mass after aCGH analysis. METHODS: Fifty-one preimplantation genetic diagnosis/preimplantation genetic screening of abnormal blastocysts diagnosed by array comparative genomic hybridization were included in this study. Blastocysts were thawed, incubated for 3 to 4 h, and then biopsied. Four regions were biopsied per blastocyst, including the inner cell mass (ICM), trophectoderm (TE) cells opposite the ICM, TE cells at the upper right of the ICM, and TE cells at the lower right of the ICM...
February 10, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28188592/redirecting-reproductive-immunology-research-toward-pregnancy-as-a-period-of-temporary-immune-tolerance
#8
Norbert Gleicher, Vitaly A Kushnir, David H Barad
Referring to two recent publications, we here propose that clinical reproductive immunology has for decades stagnated because reproductive medicine, including assisted reproduction (AR), has failed to accept embryo implantation as an immune system-driven process, dependent on establishment of maternal tolerance toward the implanting fetal semi-allograft (and complete allograft in cases of oocyte donation). Pregnancy represents a biologically unique period of temporary (to the period of gestation restricted) tolerance, otherwise only known in association with parasitic infections...
February 10, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28185121/the-association-between-coenzyme-q10-concentrations-in-follicular-fluid-with-embryo-morphokinetics-and-pregnancy-rate-in-assisted-reproductive-techniques
#9
Süleyman Akarsu, Funda Gode, Ahmet Zeki Isik, Zeliha Günnur Dikmen, Mustafa Agah Tekindağ
PURPOSE: This study seeks to evaluate the association between follicular fluid (FF) coenzyme Q10 (CoQ10) levels, embryo morphokinetics, and pregnancy rate. METHODS: Sixty infertile patients who underwent intracytoplasmic sperm injection (ICSI) cycles were included in the study. For each patient, CoQ10 level of the follicular fluid was measured by high-performance liquid chromatography system. After the ICSI of each oocyte, the relationship between the level of CoQ10 content of each follicular fluid, the subsequent embryo quality, and embryo morphokinetics was investigated...
February 9, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28185120/-one-for-sorrow-two-for-joy-american-embryo-transfer-guideline-recommendations-practices-and-outcomes-for-gestational-surrogate-patients
#10
REVIEW
Pamela M White
In January 2016, Melissa Cook, a California gestational surrogate experiencing a multiple-birth pregnancy following the in vitro fertilization (IVF) transfer of three embryos comprised of donor eggs and sperm provided by the intended father, went to the media when the intended father requested that she undergo a fetal reduction because twins were less expensive to raise than triplets. Much of the legal interest in this case to date has centered on the enforceability of surrogacy contracts. However, the Cook case also raises troubling issues about fertility treatment practices involving gestational surrogates, twin preference, and third-party reproduction medical decision-making...
February 9, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28181051/oxygen-tension-in-embryo-culture-does-a-shift-to-2-o2-in-extended-culture-represent-the-most-physiologic-system
#11
REVIEW
Scott J Morin
There has been much debate regarding the optimal oxygen tension in clinical embryo culture. The majority of the literature to date has compared 5% oxygen to atmospheric levels (20-21%). While the majority of modern IVF labs have accepted the superiority of 5% oxygen tension, a new debate has emerged regarding whether a further reduction after day 3 of development represents the most physiologic system. This new avenue of research is based on the premise that oxygen tension is in fact lower in the uterus than in the oviduct and that the embryo crosses the uterotubal junction sometime on day 3...
February 8, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28181050/outcome-of-gestational-surrogacy-according-to-ivf-protocol
#12
Ronit Machtinger, Nir-Ram Duvdevani, Oshrit Lebovitz, Jehoshua Dor, Ariel Hourvitz, Raoul Orvieto
PURPOSE: Surrogacy remains the only option for having a biologic child for a unique population of women with severe medical conditions. However, no study has looked at surrogacy outcome as a result of the type of ovarian stimulation of the intended mother [controlled ovarian stimulation (COH), modified natural cycle (MNC), and in vitro maturation (IVM)] for oocyte retrieval. METHODS: This is a retrospective study, including all intended mothers and gestational carriers in a tertiary, university affiliated, medical center, from 1998 to 2016...
February 8, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28161857/on-developing-a-thesis-for-reproductive-endocrinology-and-infertility-fellowship-a-case-study-of-ultra-low-2-oxygen-tension-for-extended-culture-of-human-embryos
#13
REVIEW
Daniel J Kaser
Fellows in Reproductive Endocrinology and Infertility training are expected to complete 18 months of clinical, basic, or epidemiological research. The goal of this research is not only to provide the basis for the thesis section of the oral board exam but also to spark interest in reproductive medicine research and to provide the next generation of physician-scientists with a foundational experience in research design and implementation. Incoming fellows often have varying degrees of training in research methodology and, likewise, different career goals...
February 4, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28138870/the-impact-of-rabl2b-gene-rs144944885-on-human-male-infertility-in-patients-with-oligoasthenoteratozoospermia-and-immotile-short-tail-sperm-defects
#14
Seyedeh Hanieh Hosseini, Mohammad Ali Sadighi Gilani, Anahita Mohseni Meybodi, Marjan Sabbaghian
PURPOSE: Male infertility is a multifactorial disorder with impressively genetic basis; besides, sperm abnormalities are the cause of numerous cases of male infertility. In this study, we evaluated the genetic variants in exons 4 and 5 and their intron-exon boundaries in RABL2B gene in infertile men with oligoasthenoteratozoospermia (OAT) and immotile short tail sperm (ISTS) defects to define if there is any association between these variants and human male infertility. METHODS: To this purpose, DNA was extracted from peripheral blood and after PCR reaction and sequencing, the results of sequenced segments were analyzed...
January 30, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28130663/explaining-the-futility-of-the-reproductive-process-in-humans-past-present-and-future
#15
EDITORIAL
David F Albertini
No abstract text is available yet for this article.
January 27, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28120130/erratum-to-86-successful-births-and-9-ongoing-pregnancies-worldwide-in-women-transplanted-with-frozen-thawed-ovarian-tissue-focus-on-birth-and-perinatal-outcome-in-40-of-these-children
#16
Annette Klüver Jensen, Kirsten Tryde Macklon, Jens Fedder, Erik Ernst, Peter Humaidan, Claus Yding Andersen
No abstract text is available yet for this article.
January 24, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28116645/long-term-effects-of-repeated-superovulation-on-the-uterus-and-mammary-gland-in-rhesus-monkeys
#17
Peipei Yan, Jingyi Xu, Yan Zeng, Guoying Dong, Huarong Cao, Meimei Zheng, Hui Zhu
PURPOSE: The aim of this study is to evaluate the effect of repeated controlled ovarian hyperstimulation (COH) on the structure and function of the uterus and mammary gland. METHODS: Three adult female rhesus monkeys were superovulated up to four times, and three spontaneously ovulating monkeys were used as controls. After a 5-year period, the uterus and mammary gland tissue samples were collected for examination of their structure and function. Further, the expression of certain tumor markers was examined to assess the cancer risk for each organ...
January 23, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28108842/genetic-analysis-of-the-m2-anxa5-haplotype-as-recurrent-pregnancy-loss-predisposition-in-the-malay-population
#18
Kai-Cheen Ang, Sushilnathan Kathirgamanathan, Ewe Seng Ch'ng, Yan-Yeow Lee, Anna-Liza Roslani, Bavanandan Naidu, Krishna Kumar, Ridzuan Abdullah, Siti-Nadiah Abdul Kadir, Narazah Mohd Yusoff, Wan Zaidah Abdullah, Nadja Bogdanova, Peter Wieacker, Arseni Markoff, Thean-Hock Tang
PURPOSE: The aim of this study was to evaluate a new predisposition factor, M2/ANXA5 (RPRGL3), in recurrent pregnancy loss (RPL) patients of Malay origin, since it was previously known that the prevalence of this condition is relatively high among the Malay population of Malaysia, where conventional hereditary thrombophilia factors have been generally ruled out. METHODS: A total of 232 women who had experienced ≥2 unexplained RPL and 141 available male partners were recruited, with 360 healthy Malay and 166 parous female controls...
January 20, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28108841/increased-incidence-of-post-term-delivery-and-cesarean-section-after-frozen-thawed-embryo-transfer-during-a-hormone-replacement-cycle
#19
Kazuki Saito, Kenji Miyado, Kenji Yamatoya, Akira Kuwahara, Eisuke Inoue, Mami Miyado, Maki Fukami, Tomonori Ishikawa, Takakazu Saito, Toshiro Kubota, Hidekazu Saito
PURPOSE: This study aimed to clarify the risks of adverse pregnancy outcomes in patients who conceive singletons after frozen embryo transfer (FET) during a hormone replacement cycle and their offspring. METHODS: A retrospective cohort study was conducted in patients who conceived after FET, based on the Japanese-assisted reproductive technology registry for 2013. The perinatal outcomes in cases with live-born singletons achieved through natural ovulatory cycle FET (NC-FET) (n = 6287) or hormone replacement cycle FET (HRC-FET) (n = 10,235) were compared...
January 20, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28091759/to-freeze-or-not-to-freeze-heating-the-debate-but-cooling-the-practice
#20
EDITORIAL
Paolo F Rinaudo, John Hsu
No abstract text is available yet for this article.
January 14, 2017: Journal of Assisted Reproduction and Genetics
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