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Journal of Assisted Reproduction and Genetics

Dana Kimelman, Rafael Confino, Edmond Confino, Lee P Shulman, John X Zhang, Mary Ellen Pavone
PURPOSE: Patients undergoing in-vitro fertilization (IVF) with preimplantation genetic screening (PGS) are counseled about the limitations of this technique. As part of the consent process for PGS, physicians recommend diagnostic genetic testing performed in early pregnancy to definitively rule out chromosomal abnormalities. We have noted anecdotally, however, that few patients undergo the recommended diagnostic testing. In this study, we are examining if women who conceived using IVF-PGS did early pregnancy chromosomal testing, and if they did, what type of testing they had...
August 16, 2018: Journal of Assisted Reproduction and Genetics
Mark Lubinsky
Common human reproductive inefficiencies have multiple etiologies. Going against chance, many effects, such as polycystic ovaries, endometriosis, and folate metabolic issues, have genetic components, while aneuploid losses arise from diverse mitotic and meiotic errors at different stages, some transitory. This can be advantageous, since greater overall survival with fewer offspring can increase reproductive success. Benefits primarily accrue to mothers, who bear most child related costs, and for whom early losses are less costly than late...
August 16, 2018: Journal of Assisted Reproduction and Genetics
Rocio Rivera-Egea, Nicolas Garrido, Nerea Sota, Marcos Meseguer, Jose Remohí, Francisco Dominguez
Although assisted reproduction techniques involve the use of semen samples, there is little scientific methodology applied when selecting sperm. To select the most appropriate spermatozoa, first we need to define the optimal molecular characteristics. Sperm lipids may contribute to sperm function, thus our aim was to compare the lipidic profiles of sperm samples used in intracytoplasmic sperm injection cycles that ultimately led to a pregnancy with those that did not.Spermatozoa from infertile patients after intracytoplasmic sperm injection (group non-pregnant, n = 16; vs...
August 14, 2018: Journal of Assisted Reproduction and Genetics
Paolo Emanuele Levi-Setti, Luciano Negri, Annamaria Baggiani, Emanuela Morenghi, Elena Albani, Valentina Parini, Luca Cafaro, Carola Maria Conca Dioguardi, Amalia Cesana, Antonella Smeraldi, Armando Santoro
PURPOSE: To analyse the impact of female characteristics on assisted reproductive technology outcome among male haematological cancer survivors. METHODS: A retrospective analysis of 93 haematological cancer survivors attending our tertiary referral fertility centre between June 1998 and June 2017 for achieving fatherhood with assisted reproductive technology treatments. RESULTS: A progressive increase in the median female age was observed during the study period (32...
August 10, 2018: Journal of Assisted Reproduction and Genetics
Sharon H Anderson, Michael J Glassner, Andrey Melnikov, Gary Friedman, Zulfiya Orynbayeva
PURPOSE: Oocyte competence is critical in success of assisted reproduction. Metabolic signaling between oocyte and cumulus cells within the cumulus-oocyte complex procure oocyte development. This study evaluated the relationship between respirometric activity of cumulus cells and maturity of corresponding oocytes. METHODS: In prospective cohort study, 20 women of age 28-42 undergoing IVF procedure were involved. To evaluate oocyte maturity, the cumulus cells from individual oocytes were assessed flow cytometrically by double labeling of cells with mitochondria specific dyes...
August 9, 2018: Journal of Assisted Reproduction and Genetics
Tiffany Phyoe-Battaglia, Chantal Bartels, John Nulsen, Daniel R Grow
No abstract text is available yet for this article.
August 9, 2018: Journal of Assisted Reproduction and Genetics
Alessandro Mussa, Diana Carli, Simona Cardaropoli, Cristina Molinatto, Giovanni Battista Ferrero
No abstract text is available yet for this article.
August 8, 2018: Journal of Assisted Reproduction and Genetics
Brandy Lamb, Erin Johnson, Leslie Francis, Melinda Fagan, Naomi Riches, Isabella Canada, Alena Wilson, Amber Mathiesen, Maya Sabatello, Shawn Gurtcheff, Erica Johnstone, Erin Rothwell
PURPOSE: Embryo testing to improve pregnancy outcomes among individuals who are seeking assisted reproduction technologies is increasing. The purpose of this study was to assess decisional factors through in-depth interviews for why women would accept or decline preimplantation genetic testing for aneuploidy (PGT-A) with in vitro fertilization (IVF). METHODS: Semi-structured telephone interviews were conducted with 37 women who were offered PGT-A with IVF during the summer 2017...
August 3, 2018: Journal of Assisted Reproduction and Genetics
Marcia C Inhorn, Daphna Birenbaum-Carmeli, Lynn M Westphal, Joseph Doyle, Norbert Gleicher, Dror Meirow, Martha Dirnfeld, Daniel Seidman, Arik Kahane, Pasquale Patrizio
PURPOSE: What are the specific pathways that lead women to freeze their eggs? In this binational study, women were asked directly about the life circumstances that led them on the path to elective egg freezing (EEF). METHODS: From June 2014 to August 2016, 150 women (114 in the USA, 36 in Israel) who had completed at least 1 cycle of EEF were interviewed by two medical anthropologists. Study participants were recruited through four American IVF clinics (two academic, two private) and three in Israel (one academic, two private)...
August 3, 2018: Journal of Assisted Reproduction and Genetics
L Parmegiani, K H Beilby, A Arnone, S Bernardi, A M Maccarini, E Nardi, G E Cognigni, M Filicori
PURPOSE: To study the efficacy and efficiency of a "universal warming protocol" for vitrified human embryos, based on subsequent steps with 1 and 0.5 M concentration of extracellular cryoprotectant (ECCP). METHOD: Two studies on patients undergoing fertility treatments via ICSI: a prospective randomized controlled trial (RCT) and a retrospective cohort study (CS). SETTING: Private assisted reproductive (AR) center. RCT: duration 01/03/2017-01/10/2017; 315 embryos at blastocyst stage obtained from 169 patients...
August 3, 2018: Journal of Assisted Reproduction and Genetics
Rani Fritz, Susan Klugman, Harry Lieman, Jay Schulkin, Laura Taouk, Neko Castleberry, Erkan Buyuk
PURPOSE: What are the experience, approach, and knowledge of US Obstetricians and Gynecologists' (ob-gyn) towards counseling patients on reproductive aging (RA) and elective fertility preservation (EFP). METHODS: A cross-sectional survey emailed by the American College of Obstetricians and Gynecologists (ACOG) to 5000 ACOG fellows consisting of 9 demographic and 28 questions relating to counseling patients on RA and EFP. RESULTS: Seven hundred and eighty-four responders completed the survey...
August 2, 2018: Journal of Assisted Reproduction and Genetics
David F Albertini
No abstract text is available yet for this article.
August 2, 2018: Journal of Assisted Reproduction and Genetics
Maria Antonietta Castiglione Morelli, Assunta Iuliano, Sergio Crescenzo Antonio Schettini, Donatina Petruzzi, Angela Ferri, Paola Colucci, Licia Viggiani, Flavia Cuviello, Angela Ostuni
PURPOSE: The purpose of this study was to evaluate the possible application of metabolomics to identify follicular fluid changes in cancer patients undergoing fertility preservation. Although metabolomics have been applied already in cancer studies, this is the first application on follicular fluid of cancer patients. METHODS: We selected for the study ten patients with breast cancer and lymphoma who resorted to oocyte cryopreservation to preserve fertility and ten healthy women undergoing in vitro fertilization treatments...
August 1, 2018: Journal of Assisted Reproduction and Genetics
Allison Briggs, Parvaneh K Nouri, Michael Galloway, Kathleen O'Leary, Nigel Pereira, Steven R Lindheim
PURPOSE: Expanded carrier screening (ECS) is an available component of preconception and prenatal care. There is complexity around offering, administering, and following-up test results. The goal of this study is to evaluate current physicians' utilization and attitudes towards ECS in current practice. METHODS: This was a prospective qualitative survey study. A 32-question electronic survey was distributed during a 1-year period to obstetricians-gynecologists who were identified using a Qualtrics listserv database...
August 1, 2018: Journal of Assisted Reproduction and Genetics
Michael H Dahan, Seang Lin Tan
No abstract text is available yet for this article.
August 1, 2018: Journal of Assisted Reproduction and Genetics
Randi H Goldman, Catherine Racowsky, Leslie V Farland, Janis H Fox, Santiago Munné, Lia Ribustello, Elizabeth S Ginsburg
PURPOSE: To determine the expected out-of-pocket costs of IVF with preimplantation genetic testing for aneuploidy (PGT-A) to attain a 50%, 75%, or 90% likelihood of a euploid blastocyst based on individual age and AMH, and develop a personalized counseling tool. METHODS: A cost analysis was performed and a counseling tool was developed using retrospective data from IVF cycles intended for PGT or blastocyst freeze-all between January 1, 2014 and August 31, 2017 (n = 330) and aggregate statistics on euploidy rates of > 149,000 embryos from CooperGenomics...
July 31, 2018: Journal of Assisted Reproduction and Genetics
N Sinha, J M Letourneau, K Wald, P Xiong, Tal Imbar, B Li, E Harris, E Mok-Lin, M I Cedars, Mitchell P Rosen
PURPOSE: After chemotherapy for breast cancer, most women will recover some ovarian function, but the timing and extent of this recovery are poorly understood. We studied post-chemotherapy ovarian recovery in women with and without a history of ovarian suppression during chemotherapy. METHODS: Reproductive age breast cancer patients who were seen prior to chemotherapy for fertility preservation consult were consented for follow-up ovarian function assessment (every 3-6 months after chemotherapy) with antral follicle count (AFC) in this prospective cohort study...
July 31, 2018: Journal of Assisted Reproduction and Genetics
Israel Ortega, Juan A García-Velasco, Antonio Pellicer
Current knowledge on ovarian physiology has challenged the traditional concept of folliculogenesis, creating the basis for novel ovarian stimulation protocols in assisted reproduction technology. The purpose of this review was to evaluate the efficacy of novel clinical interventions that could aid clinicians in individualizing their protocols to patients' characteristics and personal situations. We conducted a literature review of the available evidence on new approaches for ovarian stimulation from both retrospective and prospective studies in the PubMed database...
July 28, 2018: Journal of Assisted Reproduction and Genetics
C L O'Neill, A Parrella, D Keating, S Cheung, Z Rosenwaks, G D Palermo
OBJECTIVE: To design a reproductive treatment algorithm based on the sperm DNA fragmentation (SDF) for couples with unexplained infertility following a poor intrauterine insemination (IUI) outcome. DESIGN: Couples that failed IUI with no apparent reproductive issue in both partners were allocated to diverse reproductive treatments on the basis of SDF. SETTING: Reproductive medical center in an academic setting. PATIENT(S): Over 4 years, couples with an unexpected poor IUI outcome and no apparent female or male partner reproductive issues were recruited...
July 28, 2018: Journal of Assisted Reproduction and Genetics
Mara Simopoulou, Konstantinos Sfakianoudis, Evangelos Maziotis, Nikolaos Antoniou, Anna Rapani, George Anifandis, Panagiotis Bakas, Stamatis Bolaris, Agni Pantou, Konstantinos Pantos, Michael Koutsilieris
Mathematics rules the world of science. Innovative technologies based on mathematics have paved the way for implementation of novel strategies in assisted reproduction. Ascertaining efficient embryo selection in order to secure optimal pregnancy rates remains the focus of the in vitro fertilization scientific community and the strongest driver behind innovative approaches. This scoping review aims to describe and analyze complex models based on mathematics for embryo selection, devices, and software most widely employed in the IVF laboratory and algorithms in the service of the cutting-edge technology of artificial intelligence...
July 27, 2018: Journal of Assisted Reproduction and Genetics
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