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Journal of Assisted Reproduction and Genetics

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https://www.readbyqxmd.com/read/29691711/biomechanics-and-mechanical-signaling-in-the-ovary-a-systematic-review
#1
REVIEW
Jaimin S Shah, Reem Sabouni, Kamaria C Cayton Vaught, Carter M Owen, David F Albertini, James H Segars
PURPOSE: Mammalian oogenesis and folliculogenesis share a dynamic connection that is critical for gamete development. For maintenance of quiescence or follicular activation, follicles must respond to soluble signals (growth factors and hormones) and physical stresses, including mechanical forces and osmotic shifts. Likewise, mechanical processes are involved in cortical tension and cell polarity in oocytes. Our objective was to examine the contribution and influence of biomechanical signaling in female mammalian gametogenesis...
April 24, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29687370/performance-comparison-of-two-whole-genome-amplification-techniques-in-frame-of-multifactor-preimplantation-genetic-testing
#2
Ludmila Volozonoka, Dmitry Perminov, Liene Korņejeva, Baiba Alkšere, Natālija Novikova, Evija Jokste Pīmane, Arita Blumberga, Inga Kempa, Anna Miskova, Linda Gailīte, Violeta Fodina
PURPOSE: To compare multiple displacement amplification and OmniPlex whole genome amplification technique performance during array comparative genome hybridization (aCGH), Sanger sequencing, SNaPshot and fragment size analysis downstream applications in frame of multifactor embryo preimplantation genetic testing. METHODS: Preclinical workup included linked short tandem repeat (STR) marker selection and primer design for loci of interest. It was followed by a family haplotyping, after which an in vitro fertilization preimplantation genetic testing (IVF-PGT) cycle was carried out...
April 23, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29679182/non-o-blood-group-and-outcomes-of-in-vitro-fertilization
#3
M Di Nisio, A Ponzano, G M Tiboni, M D Guglielmi, A W S Rutjes, E Porreca
PURPOSE: Retrospective and cross-sectional studies suggested that non-O blood group may be associated with failures of in vitro fertilization (IVF), but data remain controversial. The aim of this observational cohort study was to prospectively evaluate the effect of non-O blood type on clinical outcomes of IVF. METHODS: Women < 40 years who underwent IVF and had ABO blood type recorded as part of the routine workup were eligible. The primary study outcome was live birth...
April 20, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29679181/essential-learning-tools-for-continuing-medical-education-for-physicians-geneticists-nurses-allied-health-professionals-mental-health-professionals-business-administration-professionals-and-reproductive-endocrinology-and-infertility-rei-fellows-the-midwest
#4
REVIEW
Gretchen G Collins, Roohi Jeelani, Angeline Beltsos, William G Kearns
Essential learning tools for continuing medical education are a challenge in today's rapidly evolving field of reproductive medicine. The Midwest Reproductive Symposium International (MRSi) is a yearly conference held in Chicago, IL. The conference is targeted toward physicians, geneticists, nurses, allied health professionals, mental health professionals, business administration professionals, and reproductive endocrinology and infertility (REI) fellows engaged in the practice of reproductive medicine. In addition to the scientific conference agenda, there are specific sessions for nurses, mental health professionals, and REI fellows...
April 20, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29667045/issues-related-to-human-oocyte-vitrification-a-consideration-of-the-facts
#5
LETTER
Samer Tannus, Michael-Haim Dahan, Justin Tan, Seang-Lin Tan
No abstract text is available yet for this article.
April 17, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29654525/detection-of-a-case-of-angelman-syndrome-caused-by-an-imprinting-error-in-949-pregnancies-analyzed-for-as-following-ivf
#6
John P Johnson, Jonathon Schoof, Linda Beischel, Corbin Schwancke, James Goldberg, Lauri Black, Lori Ross, Suchina Bhatt
No abstract text is available yet for this article.
April 13, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29637506/lower-blastocyst-quality-after-conventional-vs-piezo-icsi-in-the-horse-reflects-delayed-sperm-component-remodeling-and-oocyte-activation
#7
R M Salgado, J G Brom-de-Luna, H L Resende, H S Canesin, Katrin Hinrichs
PURPOSE: The aim of this study was to evaluate the differential effects of conventional and Piezo-driven ICSI on blastocyst development, and on sperm component remodeling and oocyte activation, in an equine model. METHODS: In vitro-matured equine oocytes underwent conventional (Conv) or Piezo ICSI, the latter utilizing fluorocarbon ballast. Blastocyst development was compared between treatments to validate the model. Then, oocytes were fixed at 0, 6, or 18 h after injection, and stained for the sperm tail, acrosome, oocyte cortical granules, and chromatin...
April 10, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29633148/birthweight-in-infants-conceived-through-in-vitro-fertilization-following-blastocyst-or-cleavage-stage-embryo-transfer-a-national-registry-study
#8
Julia F Litzky, Sheree L Boulet, Navid Esfandiari, Yujia Zhang, Dmitry M Kissin, Regan N Theiler, Carmen J Marsit
PURPOSE: In vitro fertilization (IVF) infants have lower birthweights than their peers, predisposing them to long-term health consequences. Blastocyst transfer (BT), at day 5-6 post-fertilization, is increasing in usage, partially due to improved pregnancy outcomes over cleavage-stage transfer (CT, day 2-3). Data to date, however, have been inconclusive regarding BT's effects on birthweight. METHODS: Participants included all US autologous, single-gestation, fresh embryo transfer cycles initiated from 2007 to 2014 that resulted in a term infant (N = 124,154) from the National Assisted Reproductive Technology Surveillance System...
April 10, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29633147/mode-of-conception-does-not-affect-fetal-or-placental-growth-parameters-or-ratios-in-early-gestation-or-at-delivery
#9
Lauren W Sundheimer, Jessica L Chan, Rae Buttle, Rosemarie DiPentino, Olivia Muramoto, Kerlly Castellano, Erica T Wang, John Williams, Margareta D Pisarska
PURPOSE: Ratio of fetal weight to placenta size varies by mode of conception (fertility treatments utilized) in animals. Our objective was to assess whether fertility treatments also affect these ratios in humans. METHODS: In this retrospective study, we assessed two cohorts: (a) early gestation cohort, women with singleton pregnancies who underwent first trimester vaginal ultrasound and (b) delivered cohort, women who delivered a live-born, singleton infant with placenta disposition to pathology...
April 10, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29633146/sequential-clomiphene-corifollitrophin-alpha-as-a-technique-for-mild-controlled-ovarian-hyperstimulation-in-ivf-a-proof-of-concept-study
#10
Deirdre Zander-Fox, Michelle Lane, Hamish Hamilton, Kelton Tremellen
PURPOSE: Mild controlled ovarian hyperstimulation (COH), combined with oocyte retrieval (OR) under local anaesthesia (LA), may provide low-impact IVF. Since a single injection of corifollitrophin alfa (CFA) provides 7 days of COH, we hypothesised that clomiphene-citrate (CC) followed by CFA may provide adequate COH response from one single FSH injection. Therefore, the aim was to assess IVF outcomes after a novel clomiphene citrate/CFA (CC/CFA) protocol, compared to women undergoing standard rFSH COH protocols (good prognosis comparative cohort:GPCC) in a 1:2 matched design...
April 10, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29633145/on-the-confluence-of-reproductive-and-regenerative-medicines
#11
EDITORIAL
David F Albertini
No abstract text is available yet for this article.
April 10, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29619608/interleukin-15-concentrations-in-follicular-fluid-and-their-effect-on-oocyte-maturation-in-subfertile-women-undergoing-intracytoplasmic-sperm-injection
#12
S Spanou, D Kalogiannis, E Zapanti, M Gazouli, I A Sfontouris, C Siristatidis, George Mastorakos
PURPOSE: To calculate the concentrations of interleukin 15 (IL-15) in follicular fluid (FF) and evaluate their relation with oocyte maturation, follicle size, and patients' body mass index (BMI) and age. METHODS: Follicular fluid specimens were obtained from 56 subfertile women undergoing intracytoplasmic sperm injection (ICSI) during oocyte retrieval for measurement of IL-15 concentrations with ELISA. Wilcoxon's test and Pearson's correlation coefficient were used to correlate FF concentrations of IL-15 with follicular size and stage of oocyte maturation, along with patients' BMI and age...
April 4, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29616426/protecting-fertility-clinics-against-sperm-related-fraud-a-call-to-action
#13
LETTER
Kristy Cho, Jacob Ruiter, Michael H Dahan
No abstract text is available yet for this article.
April 4, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29607458/impact-of-high-magnification-sperm-selection-on-neonatal-outcomes-a-retrospective-study
#14
Olivier Gaspard, Pierre Vanderzwalmen, Barbara Wirleitner, Stéphanie Ravet, Frédéric Wenders, Verena Eichel, Alice Mocková, Dietmar Spitzer, Caroline Jouan, Virginie Gridelet, Henri Martens, Laurie Henry, Herbert Zech, Sophie Perrier d'Hauterive, Michelle Nisolle
PURPOSE: The aim of this study was to compare the effect of the deselection of spermatozoa presenting vacuole-like structures using IMSI (intracytoplasmic morphologically selected sperm injection) with ICSI (intracytoplasmic sperm injection) by means of neonatal outcomes. METHODS: In a retrospective two-center analysis, a total of 848 successful IMSI or ICSI cycles ending with a live birth, induced abortion, or intrauterine fetal death (IUFD) were included. RESULTS: The IMSI and ICSI groups included 332 and 655 babies or fetuses, respectively...
April 2, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29607457/preliminary-human-application-of-optical-coherence-tomography-for-quantification-and-localization-of-primordial-follicles-aimed-at-effective-ovarian-tissue-transplantation
#15
Seido Takae, Kosuke Tsukada, Ichiro Maeda, Naoki Okamoto, Yorino Sato, Haruhiro Kondo, Kiemi Shinya, Yuki Motani, Nao Suzuki
PURPOSE: The purpose of this study was to evaluate the possible clinical application of optical coherence tomography for assessing ovarian reserve in individual specimens of human ovarian tissue for fertility preservation. METHODS: Ovarian tissue examination by optical coherence tomography was performed before ovarian tissue cryopreservation. Three of the four subjects had hematological disease or cancer, and they faced a threat to their fertility due to impending chemotherapy...
April 2, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29589295/the-varicocele-argument-resurfaces
#16
Sherman Silber
A recent series of articles and reviews published in Fertility and Sterility have rekindled the more than half century debate on varicocelectomy. Every one of these articles favored strongly the repair of varicocele for male infertility. Since my review paper on this issue in 2001, published in Human Reproduction Update, and since advent of ICSI in 1993, I had thought that most reproductive physicians felt negatively about the benefit of varicocelectomy. However, more recent urological papers are causing this negative view to be re-evaluated...
March 27, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29589294/examination-of-the-ovotoxicity-of-5-fluorouracil-in-mice
#17
M Lambouras, S H Liew, K Horvay, H E Abud, J M Stringer, Karla J Hutt
PURPOSE: Undesirable side effects of cancer treatments are common and include damage to the ovary, and depletion of the follicle reserve, which if severe enough, can lead to infertility and early menopause. Antimetabolite drugs, such as 5-fluorouracil (5-FU), are not considered to be detrimental to the ovary, but the ovotoxicity of 5-FU has not been evaluated in any detail. The purpose of this study was to evaluate the effects of 5-FU on follicle number. METHODS: In this study, adult female C57Bl6 mice (n = 4-6 animals/group) received a single dose of saline or 5-FU (150 mg/kg) and markers of ovarian damage and follicle depletion were assessed 12 h and 7 days later...
March 27, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29589293/the-effect-of-day-2-versus-day-3-embryo-transfer-on-early-pregnancy-outcomes-in-women-with-a-low-yield-of-fertilized-oocytes
#18
C R Sacha, I Dimitriadis, G Christou, I Souter, C L Bormann
PURPOSE: To evaluate the differences in implantation and pregnancy rates when embryo transfer occurs on D2 versus D3 in women with a low yield of fertilized oocytes. METHODS: A total of 156 IVF/ICSI cycles from 141 women at an academic fertility center were analyzed in a retrospective fashion. Women with a low number of fertilized oocytes (≤ 2 two pronuclei (2PN) stage zygotes) who had their fresh embryo transfer on D2 or D3 were included in the study. Positive pregnancy test per IVF cycle (PPT), clinical pregnancy rate (CPR), spontaneous abortion rate (SABR), and implantation rate (IMPR) were the main outcome measures assessed...
March 27, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29574609/outcome-of-immature-oocytes-collection-of-119-cancer-patients-during-ovarian-tissue-harvesting-for-fertility-preservation
#19
Alon Kedem, Gil M Yerushalmi, Masha Brengauz, Hila Raanani, Raoul Orvieto, Ariel Hourvitz, Dror Meirow
PURPOSE: Few clinical options for fertility preservation are available to females with cancer, and data about clinical outcomes is limited. Potential supplementary approaches to fertility preservation include retrieval of immature oocytes followed by in vitro maturation (IVM) and storage. The aim of this study was to evaluate post-thawing outcomes of immature oocytes collected both by transvaginal aspiration and from excised ovarian tissue. METHODS: We conducted a retrospective cohort study of patients treated in a single tertiary center...
March 24, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29572695/the-effect-of-swim-up-and-gradient-sperm-preparation-techniques-on-deoxyribonucleic-acid-dna-fragmentation-in-subfertile-patients
#20
Yuksel Oguz, Ismail Guler, Ahmet Erdem, Mehmet Firat Mutlu, Seyhan Gumuslu, Mesut Oktem, Nuray Bozkurt, Mehmet Erdem
PURPOSE: To compare the effect of two different sperm preparation techniques, including swim-up and gradient methods on sperm deoxyribonucleic acid (DNA) fragmentation status of semen samples from unexplained and mild male factor subfertile patients undergoing intrauterine insemination (IUI). DESIGN: A prospective randomized study was conducted in 65 subfertile patients, including 34 unexplained and 31 male factor infertility to compare basal and post-procedure DNA fragmentation rates in swim-up and gradient techniques...
March 23, 2018: Journal of Assisted Reproduction and Genetics
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