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Journal of Vascular Research

Mei Wang, Youyang Hu, Yifei Fan, Yan Guo, Fanglin Chen, Shuo Chen, Qinglin Li, Zhiwu Chen
BACKGROUND/AIM: H2S is a novel vasoactivator. To verify the hypothesis that H2S may act as an endothelium-derived hyperpolarizing factor (EDHF) in the rat cerebrovasculature, the role of H2S in endothelium-derived relaxing factor (EDRF)-mediated responses was investigated. METHODS: Cystathionine-γ-lyase (CSE) was knocked down with an siRNA technique. Artery diameter, hyperpolarization and Ca2+-activated K+ (KCa) current were measured. RESULTS: CSE knockdown was indicated by a decrease in protein and mRNA expression in the rat middle cerebral artery (MCA) and cerebral basilar artery (CBA)...
October 13, 2016: Journal of Vascular Research
Yuksel Agca, Shaomin Qian, Cansu Agca, Cheikh I Seye
OBJECTIVES: Extracellular nucleotide release at the site of arterial injury mediates the proliferation and migration of vascular smooth muscle cells. Our aim was to investigate the role of the P2Y2 nucleotide receptor (P2Y2R) in neointimal hyperplasia. Approach and Results: Vascular injury was induced by the implantation of a polyethylene cuff around the femoral artery in wild-type and P2Y2R-deficient mice (P2Y2R-/-). Electron microscopy was used to analyze monocyte and lymphocyte influx to the intima 36 h after injury...
October 11, 2016: Journal of Vascular Research
Katerina Jezkova, Jana Rathouska, Ivana Nemeckova, Petra Fikrova, Eva Dolezelova, Michala Varejckova, Barbora Vitverova, Kristyna Tysonova, Agnieszka Serwadczak, Elzbieta Buczek, Carmelo Bernabeu, Jose M Lopez-Novoa, Stefan Chlopicki, Petr Nachtigal
AIMS: A soluble form of endoglin (sEng) was proposed to participate in the induction of endothelial dysfunction in small blood vessels. Here, we tested the hypothesis that high levels of sEng combined with a high-fat diet induce endothelial dysfunction in an atherosclerosis-prone aorta. METHODS AND RESULTS: Six-month-old female and male transgenic mice overexpressing human sEng (Sol-Eng+) with low (Sol-Eng+low) or high (Sol-Eng+high) levels of plasma sEng were fed a high-fat rodent diet containing 1...
October 8, 2016: Journal of Vascular Research
Florian C Roessler, Sabrina Schumacher, Andreas Sprenger, Ulrich Gärtner, Mohamed Al-Khaled, Jürgen Eggers
BACKGROUND: Patients with acute ischemic strokes frequently take an acetylsalicylic acid (ASA) premedication. We determined the impact of ASA on different thrombolysis strategies in vitro. METHODS: For two clot types made from platelet-rich plasma (one with and one without ASA) lysis rates were measured by weight loss after 1 h for five different groups: in control group A clots were solely placed in plasma; in groups B and C clots were treated with rt-PA (60 kU/ml), and in groups D and E clots were treated with desmoteplase (DSPA; 2 µg/ml)...
October 7, 2016: Journal of Vascular Research
Geoffrey W Abbott, Thomas A Jepps
Voltage-gated potassium (Kv) channels formed by Kv7 (KCNQ) α-subunits are recognized as crucial for vascular smooth muscle function, in addition to their established roles in the heart (Kv7.1) and the brain (Kv7.2-5). In vivo, Kv7 α-subunits are often regulated by KCNE subfamily ancillary (β) subunits. We investigated the effects of targeted germline Kcne4 deletion on mesenteric artery reactivity in adult male and female mice. Kcne4 deletion increased mesenteric artery contractility in response to α-adrenoceptor agonist methoxamine, and decreased responses to Kv7...
October 7, 2016: Journal of Vascular Research
Anthonius F J de Bruin, Arthur Tavy, Koene van der Sloot, Anke Smits, Bert Van Ramshorst, Christiaan E Boerma, Peter Kars, Peter G Noordzij, Djamila Boerma, Mat van Iterson
AIM: To investigate whether an image acquisition stabilizer (IAS) mounted on the sidestream dark field camera (SDF) during gastrointestinal surgery improves image stability and acquisition. METHODS: Serosal SDF imaging was compared with SDF imaging combined with an IAS (SDF + IAS) during gastrointestinal surgery. Stability was assessed as the image drift in pixels and the time to obtain stable images. The success rate was determined as the percentage of analyzable images after recording...
October 4, 2016: Journal of Vascular Research
Gábor Raffai, Julian H Lombard
This study investigated the acute effects of angiotensin-(1-7) and AVE0991 on active tone and vasodilator responses to bradykinin and acetylcholine in isolated mesenteric arteries from Sprague-Dawley rats fed a high-salt (HS; 4% NaCl) versus a normal salt (NS; 0.4% NaCl) diet. Angiotensin-(1-7) and AVE0991 elicited relaxation, and angiotensin-(1-7) unmasked vasodilator responses to bradykinin in arteries from HS-fed rats. These effects of angiotensin-(1-7) and AVE0991 were inhibited by endothelium removal, A779, PD123319, HOE140 and L-NAME...
September 28, 2016: Journal of Vascular Research
Yeting Li, Qing Zhou, ChongZhe Pei, Bo Liu, MaoQuan Li, Lu Fang, YingGang Sun, YiGang Li, Shu Meng
BACKGROUND/AIMS: Dysfunction of endothelial progenitor cell (EPCs) contributes to diabetic vascular disease. We reported that downregulated miR-126 in diabetic patients causes EPC dysfunction. The study was designed to investigate how high glucose (HG) and advanced glycation end products (AGEs) regulate miR-126 expression and whether miR-126 mediates the effects of HG and AGEs on EPCs. METHODS: We first tested the effects of glucose (5.5-50 mM) and AGEs at 50-200 mg/l on EPC proliferation and selected HG at 50 mM and AGEs at 50 mg/l for further experiments...
September 28, 2016: Journal of Vascular Research
Wonseok Kang, Joon Seok Lim, Mi-Suk Park, Gou Young Koh, Honsoul Kim
PURPOSE: Hepatic malignancies can easily develop resistance to antiangiogenic therapy, but the underlying mechanism remains poorly understood. This study explores whether antiangiogenic therapy influences the tumor vascular network and/or the vessels feeding the hepatic tumor. METHODS: Mice implanted with Lewis lung carcinoma (LLC) cells were subcutaneously injected 3 times (once every other day starting 1 week after LLC implantation) with either an antiangiogenic agent [vascular endothelial growth factor (VEGF)-Trap] or control agent (bovine serum albumin) at a dose of 25 mg/kg before performing angiography...
September 20, 2016: Journal of Vascular Research
Justyna Niderla-Bielińska, Bogdan Ciszek, Ewa Jankowska-Steifer, Aleksandra Flaht-Zabost, Grzegorz Gula, Dorota M Radomska-Leśniewska, Anna Ratajska
Angiogenesis contributes to the generation of the vascular bed but also affects the progression of many diseases, such as tumor growth. Many details of the molecular pathways controlling angiogenesis are still undefined due to the lack of appropriate models. We propose the proepicardial explant as a suitable model for studying certain aspects of angiogenesis. The proepicardium (PE) is a transient embryonic structure that contains a population of undifferentiated endothelial cells (ECs) forming a vascular net continuous with the sinus venosus...
September 15, 2016: Journal of Vascular Research
Gen Chen, Jun-Jie Wang, Cang-Bao Xu, Lei Cao, Jie Lin, Xu-Ping Qing, Si-Yu Liu, En-Qi Liu, Jie Li
Minimally modified low-density lipoprotein (mmLDL) is a well-known risk factor for cardiovascular diseases. The present study was designed to investigate the role of mmLDL in the endothelium-dependent relaxation of mouse mesenteric arteries. A sensitive myograph system was employed to examine the endothelial function of mesenteric arteries. mRNA and protein expression levels were determined using real-time PCR and Western blotting, respectively. The ultramicrostructure of mesenteric vascular beds was investigated using a transmission electron microscope...
September 1, 2016: Journal of Vascular Research
Albert Busch, Amina Holm, Nicole Wagner, Süleyman Ergün, Mathias Rosenfeld, Christoph Otto, Johannes Baur, Richard Kellersmann, Udo Lorenz
Topical application of elastase to induce arterial aneurysm formation is an emerging murine model of vascular disease. In the context of aortic abdominal aneurysm (AAA), angiotensin II infusion and porcine pancreatic elastase perfusion models are commonly used today. This study, therefore, compares matrix remodeling, inflammation, and angiogenesis as distinct features of aneurysms in two models treated with intra-/extraluminal elastase. C57BL/6 mice underwent intra-/extraluminal elastase application via laparotomy and were followed up for 4 weeks...
August 18, 2016: Journal of Vascular Research
Mingxin Wu, Xinyuan Gu, Xiujuan Li, Yanhui Li, Huaineng Zhou, Guihua Lu, ZhongKai Wu, He Huang, Lilong Tang, Jianping Zeng
BACKGROUND: C-reactive protein (CRP) is significantly associated with cardiovascular diseases; however, whether CRP plays a causal role in coronary artery disease has yet to be determined. In addition, the relationship between CRP, atherosclerosis, and inflammation remains controversial. METHODS AND RESULTS: Serum interleukin (IL)-6, IL-1β, and CRP levels were determined in 160 patients at time points around percutaneous coronary intervention (PCI) with drug-eluting stent implantation...
August 4, 2016: Journal of Vascular Research
Kang Chen, Qiu Jing Chen, Ling Jie Wang, Zhu Hui Liu, Qi Zhang, Ke Yang, Hai Bo Wang, Xiao Xiang Yan, Zhen Bin Zhu, Run Du, Rui Yan Zhang, Wei Feng Shen, Lin Lu
BACKGROUND: Our previous study suggested that heart-type fatty acid-binding protein (HFABP) levels were greatly elevated in the conditioned medium of explant culture of in-stent restenosis (ISR) tissue from diabetic minipigs compared with those of non-ISR tissue. We here verified this result in animal tissues and investigated the impact of HFABP overexpression in human aortic smooth muscle cells (hASMCs). METHODS AND RESULTS: In Western blot and real-time RT-PCR, HFABP protein and mRNA levels were significantly higher in ISR than in non-ISR tissues from minipigs, and higher in the ISR tissue from diabetic minipigs than that from nondiabetic minipigs...
July 2, 2016: Journal of Vascular Research
Marike Gabrielson, Emina Vorkapic, Maggie Folkesson, Martin Welander, Andreas Matussek, Jan Dimberg, Toste Länne, Josefin Skogberg, Dick Wågsäter
INTRODUCTION: Abdominal aortic aneurysm (AAA) is a complex and deadly vascular disorder. The pathogenesis of AAA includes destruction and phenotypic alterations of the vascular smooth muscle cells (VSMCs) and aortic tissues. PPARx03B3; coactivator-1 alpha (PGC1α) regulates VSMC migration and matrix formation and is a major inducer of mitochondrial biogenesis and function, including oxidative metabolism. METHODS: Protein and gene expression of PGC1α and markers for mitochondria biogenesis and cell type-specificity were analysed in AAA aortas from humans and mice and compared against control aortas...
June 25, 2016: Journal of Vascular Research
Jean Marie Ruddy, John S Ikonomidis, Jeffrey A Jones
The prevalence of atherosclerotic disease continues to increase, and despite significant reductions in major cardiovascular events with current medical interventions, an additional therapeutic window exists. Atherosclerotic plaque growth is a complex integration of cholesterol penetration, inflammatory cell infiltration, vascular smooth muscle cell (VSMC) migration, and neovascular invasion. A family of matrix-degrading proteases, the matrix metalloproteinases (MMPs), contributes to all phases of vascular remodeling...
June 22, 2016: Journal of Vascular Research
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2016: Journal of Vascular Research
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2016: Journal of Vascular Research
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2015: Journal of Vascular Research
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2015: Journal of Vascular Research
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