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Journal of Vascular Research

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https://www.readbyqxmd.com/read/28095372/impaired-mitochondrial-respiration-in-large-cerebral-arteries-of-rats-with-type-2-diabetes
#1
Ivan Merdzo, Ibolya Rutkai, Venkata N L R Sure, Catherine A McNulty, Prasad V G Katakam, David W Busija
Mitochondrial dysfunction has been suggested as a potential underlying cause of pathological conditions associated with type 2 diabetes (T2DM). We have previously shown that mitochondrial respiration and mitochondrial protein levels were similar in the large cerebral arteries of insulin-resistant Zucker obese rats and their lean controls. In this study, we extend our investigations into the mitochondrial dynamics of the cerebral vasculature of 14-week-old Zucker diabetic fatty obese (ZDFO) rats with early T2DM...
January 18, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28013300/notch4-signaling-pathway-of-endothelial-progenitor-cells-in-a-kawasaki-disease-model-induced-by-lactobacillus-casei-cell-wall-extract
#2
Huafeng Wang, Yuanyuan Xia, Songling Fu, Wei Wang, Chunhong Xie, Yiying Zhang, Fangqi Gong
The Notch4 signaling pathway of endothelial progenitor cells (EPCs) may play a crucial role in Kawasaki disease (KD). We investigated the proliferation, adhesion, migration, angiogenesis, and expression levels of Notch4, recombination signal-binding protein-Jκ (RBP-Jκ), P-selectin, and vascular cell adhesion molecule-1 (VCAM-1) of bone marrow (BM) EPCs in a KD model induced by Lactobacillus casei cell wall extract. The numbers of BM EPCs decreased significantly in the KD models. The Notch4 expression level on the EPC surface was higher in the KD models than in the controls...
December 24, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27997923/the-role-of-hmgb1-in-pial-arteriole-dilating-reactivity-following-subarachnoid-hemorrhage-in-rats
#3
Haoliang Xu, Benjarat Changyaleket, Tibor Valyi-Nagy, Randal O Dull, Dale A Pelligrino, David E Schwartz, Zhao Zhong Chong
High-mobility group box 1 protein (HMGB1) has been implicated in inflammatory responses, and is also associated with cerebral vasospasm after subarachnoid hemorrhage (SAH). However, there are no direct evident links between HMGB1 and cerebral vasospasm. We therefore investigated the effects of HMGB1 on pial arteriole reactivity following SAH in rats. We initially found that SAH induced a significant decrease in pial arteriole dilating responses to sciatic nerve stimulation (SNS), hypercapnia (CO2), and the topical suffusion of acetylcholine (ACh), adenosine (ADO), and s-nitroso-N-acetylpenicillamine (SNAP) over a 7-day period after SAH...
December 21, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27988519/nobiletin-relaxes-isolated-mesenteric-arteries-by-activating-the-endothelial-ca2-enos-pathway-in-rats
#4
Weiwei Yang, Shuzhen Li, Lin Liao, Xiaodong Zheng, Jiali Li, Yaqin Zheng, Xiuling Zhang, Daling Zhu
AIMS: Nobiletin, a natural polymethoxylated flavonoid compound, has various beneficial properties, such as anticancer, anti-inflammatory, and antioxidant effects, and it also improves memory. Therefore, we investigated the effects and mechanisms of nobiletin on rat isolated mesenteric arteries (MAs). METHODS: We examined vasodilation induced by nobiletin on rat isolated MA rings with a tension study, the expression and activity of endothelial nitric oxide synthase (eNOS) with Western blotting, NO production with DAF- FMDA fluorescence, and intracellular Ca2+ concentration ([Ca2+]i) with Fluo-3AM...
December 17, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27974709/adenovirus-mediated-overexpression-of-septin-2-attenuates-%C3%AE-smooth-muscle-actin-expression-and-adventitial-myofibroblast-migration-induced-by-angiotensin-ii
#5
Shu-Jie Guo, Peng Zhang, Ling-Yun Wu, Guan-Nan Zhang, Wen-Dong Chen, Ping-Jin Gao
Phenotypic transformation from adventitial fibroblasts (AFs) to myofibroblasts (MFs) is critical for vascular remodeling. Septin 2 was found to be downregulated during the differentiation of AFs to MFs induced by angiotensin II (Ang II); however, the role of septin 2 in this process is still unknown. In this study, we investigate whether septin 2 contributes to the adventitial MF phenotypic modulation caused by Ang II. The decreased level of septin 2 and the increased expression of α-smooth muscle actin (α-SMA), a marker of MFs, were readily observed in Ang II-stimulated MF differentiation...
December 15, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27974708/alveolar-hypoxia-induced-pulmonary-inflammation-from-local-initiation-to-secondary-promotion-by-activated-systemic-inflammation
#6
Ting Chen, Chengzhong Yang, Manman Li, Xiaoling Tan
Pulmonary hypertension (PH) is a pathological condition with high mortality and morbidity. Hypoxic PH (HPH) is a common form of PH occurring mainly due to lung disease and/or hypoxia. Most causes of HPH are associated with persistent or intermittent alveolar hypoxia, including exposure to high altitude and chronic obstructive respiratory disease. Recent evidence suggests that inflammation is a critical step for HPH initiation and development. A detailed understanding of the initiation and progression of pulmonary inflammation would help in exploring potential clinical treatments for HPH...
December 15, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27941325/arterial-iron-content-is-increased-in-patients-with-high-plasma-ferritin-levels
#7
Julie Bukh Madsen, Lise Pedersen, Christina Lund Kidholm, Lars Melholt Rasmussen
The association between increased amounts of stored iron and development of cardiovascular disease (CVD) has been recognized for many years. However, basic information on iron content in human arteries is limited. We envision that associations between body iron content and CVD are based on the accumulation of iron in the arteries, possibly leading to the dysfunction of cellular biochemical pathways. This study addresses the very fundamental question of whether there is a relation between body iron content and the level of iron accumulated in arterial tissue...
December 10, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27924795/alisol-a-24-acetate-a-triterpenoid-derived-from-alisma-orientale-inhibits-ox-ldl-induced-phenotypic-transformation-and-migration-of-rat-vascular-smooth-muscle-cells-through-suppressing-erk1-2-signaling
#8
Xie-Hua Xue, Xiao-Mao Zhou, Wei Wei, Tong Chen, Qing-Ping Su, Jing Tao, Li-Dian Chen
Alisol A 24-acetate, a triterpenoid extracted from Alisma orientale, has shown antiatherosclerotic actions. The purpose of this study was to evaluate the inhibition of alisol A 24-acetate on oxidized low-density lipoprotein (Ox-LDL)-induced phenotypic transformation and migration of rat vascular smooth muscle cells (VSMCs), and to explore the underlying mechanisms. VSMCs were pretreated with alisol A 24-acetate and a specific extracellular signal-regulated kinase (ERK) inhibitor, U0126, and then stimulated with 50 mg/l Ox-LDL in vitro...
December 8, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27923234/transient-receptor-potential-vanilloid-1-channels-contribute-to-the-regulation-of-acid-and-base-induced-vasomotor-responses
#9
Ivan Ivic, Margit Solymar, Eszter Pakai, Zoltan Rumbus, Erika Pinter, Akos Koller, Andras Garami
pH changes can influence local blood flow, but the mechanisms of how acids and bases affect vascular tone is not fully clarified. Transient receptor potential vanilloid-1 (TRPV1) channels are expressed in vessels and can be activated by pH alterations. Thus, we hypothesized that TRPV1 channels are involved in the mediation of vascular responses to acid-base changes. Vasomotor responses to HCl, NaOH, and capsaicin were measured in isolated murine carotid and tail skin arteries. The function of TRPV1 was blocked by either of three approaches: Trpv1 gene disruption, pharmacological blockade with a TRPV1 antagonist (BCTC), and functional impairment of mainly neural TRPV1 channels (desensitization)...
December 7, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27923233/efficacy-of-adipodren%C3%A2-in-reducing-interleukin-1-induced-lymphatic-endothelial-hyperpermeability
#10
Valerio Ciccone, Martina Monti, Giulia Antonini, Luisa Mattoli, Michela Burico, Francesca Marini, Anna Maidecchi, Lucia Morbidelli
Lymphatic leakage can be seen as a detrimental phenomenon associated with fluid retention and deposition as well as gain of weight. Moreover, lymphatic dysfunction is associated with an inflammatory environment and can be a substrate for other health conditions. A number of treatments can ameliorate lymphatic vasculature: natural substances have been used as treatment options particularly suitable for their consolidated effectiveness and safety profile. Here we report the protective effect of AdipoDren®, an association of a series of plant-derived natural complexes, on lymphatic endothelium permeability promoted by interleukin-1 beta (IL-1β) and the associated molecular mechanisms...
December 7, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27923220/differential-regulation-of-bmal1-clock-and-endothelial-signaling-in-the-aortic-arch-and-ligated-common-carotid-artery
#11
Xia Shang, Paramita Pati, Ciprian B Anea, David J R Fulton, R Daniel Rudic
The circadian clock is rhythmically expressed in blood vessels, but the interaction between the circadian clock and disturbed blood flow remains unclear. We examined the relationships between BMAL1 and CLOCK and 2 regulators of endothelial function, AKT1 and endothelial nitric oxide synthase (eNOS), in vascular regions of altered blood flow. We found that the aortic arch from WT mice exhibited reduced sensitivity to acetylcholine (Ach)-mediated relaxation relative to the thoracic aorta. In Clock-mutant (mut) mice the aorta exhibited a reduced sensitivity to Ach...
December 7, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27894114/hydroxysafflor-yellow-a-promotes-angiogenesis-via-the-angiopoietin-1-tie-2-signaling-pathway
#12
Tangting Chen, Ni Chen, Ningbo Pang, Lamei Xiao, Yongjie Li, Rong Li, Mao Luo, Xin Deng, Meiping Ren, Jianbo Wu, Liqun Wang
BACKGROUND: The flowers of Carthamus tinctorius L. are widely used in traditional Chinese medicine to treat cerebrovascular and cardiovascular diseases. Hydroxysafflor yellow A (HSYA), the main constituent of C. tinctorius L. flowers, is known for its multiple biological activities. The present study investigated the effects of HSYA on angiogenesis in vitro and in a mouse hindlimb ischemia model. METHODS: Using human umbilical vein endothelial cells (HUVEC) in vitro and a mouse hindlimb ischemia model in vivo, the angiogenic role of HSYA was evaluated...
November 29, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27673690/hyperglycemia-and-advanced-glycation-end-products-regulate-mir-126-expression-in-endothelial-progenitor-cells
#13
Yeting Li, Qing Zhou, ChongZhe Pei, Bo Liu, MaoQuan Li, Lu Fang, YingGang Sun, YiGang Li, Shu Meng
BACKGROUND/AIMS: Dysfunction of endothelial progenitor cell (EPCs) contributes to diabetic vascular disease. We reported that downregulated miR-126 in diabetic patients causes EPC dysfunction. The study was designed to investigate how high glucose (HG) and advanced glycation end products (AGEs) regulate miR-126 expression and whether miR-126 mediates the effects of HG and AGEs on EPCs. METHODS: We first tested the effects of glucose (5.5-50 mM) and AGEs at 50-200 mg/l on EPC proliferation and selected HG at 50 mM and AGEs at 50 mg/l for further experiments...
September 28, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27626281/mouse-proepicardium-exhibits-a-sprouting-response-to-exogenous-proangiogenic-growth-factors-in-vitro
#14
Justyna Niderla-Bielińska, Bogdan Ciszek, Ewa Jankowska-Steifer, Aleksandra Flaht-Zabost, Grzegorz Gula, Dorota M Radomska-Leśniewska, Anna Ratajska
Angiogenesis contributes to the generation of the vascular bed but also affects the progression of many diseases, such as tumor growth. Many details of the molecular pathways controlling angiogenesis are still undefined due to the lack of appropriate models. We propose the proepicardial explant as a suitable model for studying certain aspects of angiogenesis. The proepicardium (PE) is a transient embryonic structure that contains a population of undifferentiated endothelial cells (ECs) forming a vascular net continuous with the sinus venosus...
September 15, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27577886/minimally-modified-ldl-induced-impairment-of-endothelium-dependent-relaxation-in-small-mesenteric-arteries-of-mice
#15
Gen Chen, Jun-Jie Wang, Cang-Bao Xu, Lei Cao, Jie Lin, Xu-Ping Qing, Si-Yu Liu, En-Qi Liu, Jie Li
Minimally modified low-density lipoprotein (mmLDL) is a well-known risk factor for cardiovascular diseases. The present study was designed to investigate the role of mmLDL in the endothelium-dependent relaxation of mouse mesenteric arteries. A sensitive myograph system was employed to examine the endothelial function of mesenteric arteries. mRNA and protein expression levels were determined using real-time PCR and Western blotting, respectively. The ultramicrostructure of mesenteric vascular beds was investigated using a transmission electron microscope...
September 1, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27532120/extra-and-intraluminal-elastase-induce-morphologically-distinct-abdominal-aortic-aneurysms-in-mice-and-thus-represent-specific-subtypes-of-human-disease
#16
Albert Busch, Amina Holm, Nicole Wagner, Süleyman Ergün, Mathias Rosenfeld, Christoph Otto, Johannes Baur, Richard Kellersmann, Udo Lorenz
Topical application of elastase to induce arterial aneurysm formation is an emerging murine model of vascular disease. In the context of aortic abdominal aneurysm (AAA), angiotensin II infusion and porcine pancreatic elastase perfusion models are commonly used today. This study, therefore, compares matrix remodeling, inflammation, and angiogenesis as distinct features of aneurysms in two models treated with intra-/extraluminal elastase. C57BL/6 mice underwent intra-/extraluminal elastase application via laparotomy and were followed up for 4 weeks...
August 18, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27487299/c-reactive-protein-and-inflammatory-cytokines-during-percutaneous-coronary-intervention
#17
Mingxin Wu, Xinyuan Gu, Xiujuan Li, Yanhui Li, Huaineng Zhou, Guihua Lu, ZhongKai Wu, He Huang, Lilong Tang, Jianping Zeng
BACKGROUND: C-reactive protein (CRP) is significantly associated with cardiovascular diseases; however, whether CRP plays a causal role in coronary artery disease has yet to be determined. In addition, the relationship between CRP, atherosclerosis, and inflammation remains controversial. METHODS AND RESULTS: Serum interleukin (IL)-6, IL-1β, and CRP levels were determined in 160 patients at time points around percutaneous coronary intervention (PCI) with drug-eluting stent implantation...
August 4, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27372431/increment-of-hfabp-level-in-coronary-artery-in-stent-restenosis-segments-in-diabetic-and-nondiabetic-minipigs-hfabp-overexpression-promotes-multiple-pathway-related-inflammation-growth-and-migration-in-human-vascular-smooth-muscle-cells
#18
Kang Chen, Qiu Jing Chen, Ling Jie Wang, Zhu Hui Liu, Qi Zhang, Ke Yang, Hai Bo Wang, Xiao Xiang Yan, Zhen Bin Zhu, Run Du, Rui Yan Zhang, Wei Feng Shen, Lin Lu
BACKGROUND: Our previous study suggested that heart-type fatty acid-binding protein (HFABP) levels were greatly elevated in the conditioned medium of explant culture of in-stent restenosis (ISR) tissue from diabetic minipigs compared with those of non-ISR tissue. We here verified this result in animal tissues and investigated the impact of HFABP overexpression in human aortic smooth muscle cells (hASMCs). METHODS AND RESULTS: In Western blot and real-time RT-PCR, HFABP protein and mRNA levels were significantly higher in ISR than in non-ISR tissues from minipigs, and higher in the ISR tissue from diabetic minipigs than that from nondiabetic minipigs...
July 2, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27344146/altered-pparx03b3-coactivator-1-alpha-expression-in-abdominal-aortic-aneurysm-possible-effects-on-mitochondrial-biogenesis
#19
Marike Gabrielson, Emina Vorkapic, Maggie Folkesson, Martin Welander, Andreas Matussek, Jan Dimberg, Toste Länne, Josefin Skogberg, Dick Wågsäter
INTRODUCTION: Abdominal aortic aneurysm (AAA) is a complex and deadly vascular disorder. The pathogenesis of AAA includes destruction and phenotypic alterations of the vascular smooth muscle cells (VSMCs) and aortic tissues. PPARx03B3; coactivator-1 alpha (PGC1α) regulates VSMC migration and matrix formation and is a major inducer of mitochondrial biogenesis and function, including oxidative metabolism. METHODS: Protein and gene expression of PGC1α and markers for mitochondria biogenesis and cell type-specificity were analysed in AAA aortas from humans and mice and compared against control aortas...
June 25, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27327039/multidimensional-contribution-of-matrix-metalloproteinases-to-atherosclerotic-plaque-vulnerability-multiple-mechanisms-of-inhibition-to-promote-stability
#20
Jean Marie Ruddy, John S Ikonomidis, Jeffrey A Jones
The prevalence of atherosclerotic disease continues to increase, and despite significant reductions in major cardiovascular events with current medical interventions, an additional therapeutic window exists. Atherosclerotic plaque growth is a complex integration of cholesterol penetration, inflammatory cell infiltration, vascular smooth muscle cell (VSMC) migration, and neovascular invasion. A family of matrix-degrading proteases, the matrix metalloproteinases (MMPs), contributes to all phases of vascular remodeling...
June 22, 2016: Journal of Vascular Research
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