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Journal of Vascular Research

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https://www.readbyqxmd.com/read/28490016/backup-mechanisms-maintain-pacap-vip-induced-arterial-relaxations-in-pituitary-adenylate-cyclase-activating-polypeptide-deficient-mice
#1
Ivan Ivic, Balazs D Fulop, Tamas Juhasz, Dora Reglodi, Gabor Toth, Hitoshi Hashimoto, Andrea Tamas, Akos Koller
BACKGROUND: Pituitary adenylate cyclase-activating polypeptide (PACAP) is a multifunctional neuropeptide in the VIP/secretin/glucagon peptide superfamily. Two active forms, PACAP1-38 and PACAP1-27, act through G protein-coupled receptors, the PAC1 and VPAC1/2 receptors. Effects of PACAP include potent vasomotor activity. Vasomotor activity and organ-specific vasomotor effects of PACAP-deficient mice have not yet been investigated; thus, the assessment of its physiological importance in vasomotor functions is still missing...
May 11, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28478449/insulin-antagonizes-thrombin-induced-microvessel-leakage
#2
Yan Liu, Xue Lian Chen, Lei Wang, Manuela Martins-Green
Sustained increase in microvessel permeability results in cell and tissue damage. To date, it has not been possible to safely and specifically block increased microvessel permeability in vivo. We showed that insulin stimulates angiogenesis and that the new microvessels are associated with more αSMA-producing cells, suggesting greater stability. In this study, we show that local injection of insulin under the skin of mice significantly inhibits thrombin-induced microvessel permeability and that insulin improves the barrier function of primary human endothelial cells under conditions that mimic endothelium in vivo...
May 6, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28478461/overexpression-of-toll-like-receptors-2-3-4-and-8-is-correlated-to-the-vascular-atherosclerotic-process-in-the-hyperlipidemic-rabbit-model-the-effect-of-statin-treatment
#3
Alkistis Kapelouzou, Stavros Giaglis, Michalis Peroulis, Michalis Katsimpoulas, Petros Moustardas, Chrysostomos V Aravanis, Alkiviadis Kostakis, Panagiotis E Karayannakos, Dennis V Cokkinos
BACKGROUND: Atherosclerosis is the major cause of cardiovascular disease; hypercholesterolemia is a major risk factor. We hypothesized that specific TLR members (TLR2, TLR3, TLR4, TLR8) may play a role in atherosclerosis progression and its accompanying inflammatory response. We determined the association of atherosclerotic lesions and TLR mRNA expression in different aortic sites. We also assessed the effects of fluvastatin (Flu) treatment on TLR expression and plaque characteristics...
May 5, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28472795/role-of-organic-anion-transporters-in-the-uptake-of-protein-bound-uremic-toxins-by-human-endothelial-cells-and-monocyte-chemoattractant-protein-1-expression
#4
Giane Favretto, Lauro M Souza, Paulo C Gregório, Regiane S Cunha, Rayana A P Maciel, Guilherme L Sassaki, Maria G Toledo, Roberto Pecoits-Filho, Wesley M Souza, Andréa E M Stinghen
Organic anion transporters (OATs) are involved in the uptake of uremic toxins such as p-cresyl sulfate (PCS) and indoxyl sulfate (IS), which play a role in endothelial dysfunction in patients with chronic kidney diseases (CKD). In this study, we investigated the role of OAT1 and OAT3 in the uptake of PCS and IS into human endothelial cells. PCS was synthesized via p-cresol sulfation and characterized using analytical methods. The cells were treated with PCS and IS in the absence and presence of probenecid (Pb), an OAT inhibitor...
May 5, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28468000/protective-function-of-ahnak1-in-vascular-healing-after-wire-injury
#5
Nadine Haase, Constantin Rüder, Hannelore Haase, Stefanie Kamann, Michiyoshi Kouno, Ingo Morano, Ralf Dechend, Dietlind Zohlnhöfer, Tobias Haase
AIM: Vascular remodeling following injury substantially accounts for restenosis and adverse clinical outcomes. In this study, we investigated the role of the giant scaffold protein Ahnak1 in vascular healing after endothelial denudation of the murine femoral artery. METHODS: The spatiotemporal expression pattern of Ahnak1 and Ahnak2 was examined using specific antibodies and real-time quantitative PCR. Following wire-mediated endothelial injury of Ahnak1-deficient mice and wild-type (WT) littermates, the processes of vascular healing were analyzed...
May 4, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28448973/downregulations-of-cd36-and-calpain-1-inflammation-and-atherosclerosis-by-simvastatin-in-apolipoprotein-e-knockout-mice
#6
Meihui Yin, Qianqian Liu, Lan Yu, Yueyan Yang, Meili Lu, Hongxin Wang, Duosheng Luo, Xianglu Rong, Futian Tang, Jiao Guo
BACKGROUND: In the previous in vitro study, we found that simvastatin decreased the protein expression of CD36, the scavenger receptor, and calpain-1, the Ca2+-sensitive cysteine protease, in oxidized low-density lipoprotein (oxLDL)-treated macrophages. In this in vivo study, we investigated whether simvastatin downregulates the expression of CD36 and calpain-1 and inhibits the inflammation and atherosclerosis in apolipoprotein E knockout (ApoE KO) mice. METHODS: Twenty male 6-week-old ApoE KO mice were divided into 2 groups: the ApoE KO group and the ApoE KO + simvastatin (ApoE KO + Sim) group...
April 28, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28535497/esm-evbo-2017-2nd-joint-meeting-of-the-european-society-for-microcirculation-esm-and-european-vascularbiology-organisation-evbo-geneva-switzerland-29-may-to-1-june-2017-abstracts
#7
https://www.readbyqxmd.com/read/28441653/effect-of-topical-iloprost-and-nitroglycerin-on-gastric-microcirculation-and-barrier-function-during-hemorrhagic-shock-in-dogs
#8
Richard Truse, Jonas Hinterberg, Jan Schulz, Anna Herminghaus, Andreas Weber, Tabea Mettler-Altmann, Inge Bauer, Olaf Picker, Christian Vollmer
BACKGROUND: Topical drug application is used to avoid systemic side effects. The aim of this study was to analyze whether locally applied iloprost or nitroglycerin influence gastric mucosal perfusion, oxygenation, and barrier function during physiological and hemorrhagic conditions. METHODS: In repeated experiments, 5 anesthetized dogs received iloprost, nitroglycerin, or normal saline during physiological and hemorrhagic (-20% blood volume) conditions. Macro- and microcirculatory variables were recorded continuously...
2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28407626/exogenous-mirna-146a-enhances-the-therapeutic-efficacy-of-human-mesenchymal-stem-cells-by-increasing-vascular-endothelial-growth-factor-secretion-in-the-ischemia-reperfusion-injured-heart
#9
Hyang-Hee Seo, Se-Yeon Lee, Chang Youn Lee, Ran Kim, Pilseog Kim, Sekyung Oh, Hojin Lee, Min Young Lee, Jongmin Kim, Lark Kyun Kim, Ki-Chul Hwang, Woochul Chang
Adult stem cells have been studied as a promising therapeutic modality for the functional restoration of the damaged heart. In the present study, a strategy for enhancing the angiogenic efficacy of human mesenchymal stem cells (hMSCs) using micro-RNA was examined. We investigated whether micro-RNA-146a (miR-146a) influences the secretion of vascular endothelial growth factor (VEGF) and angiogenesis of MSCs. Our data indicated that miR-146a-transfected hMSCs (hMSCmiR-146a) decreased the expression of neurofibromin 2, an inhibitor of p21-activated kinase-1 (PAK1)...
2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28402977/molecular-mechanisms-leading-to-splanchnic-vasodilation-in-liver-cirrhosis
#10
Marco Di Pascoli, David Sacerdoti, Patrizia Pontisso, Paolo Angeli, Massimo Bolognesi
In liver cirrhosis, portal hypertension is a consequence of enhanced intrahepatic vascular resistance and portal blood flow. Significant vasodilation in the arterial splanchnic district is crucial for an increase in portal flow. In this pathological condition, increased levels of circulating endogenous vasodilators, including nitric oxide, prostacyclin, carbon monoxide, epoxyeicosatrienoic acids, glucagon, endogenous cannabinoids, and adrenomedullin, and a decreased vascular response to vasoconstrictors are the main mechanisms underlying splanchnic vasodilation...
2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28376507/the-role-of-o-glcnacylation-in-perivascular-adipose-tissue-dysfunction-of-offspring-of-high-fat-diet-fed-rats
#11
Karolina E Zaborska, Gillian Edwards, Clare Austin, Mark Wareing
Perivascular adipose tissue (PVAT), which reduces vascular contractility, is dysfunctional in the male offspring of rats fed a high-fat diet (HFD), partially due to a reduced NO bioavailability. O-GlcNAcylation of eNOS decreases its activity, thus we investigated the role of O-GlcNAcylation in the prenatal programming of PVAT dysfunction. Female Sprague-Dawley rats were fed either a control (10% fat) or an obesogenic HFD (45% fat) diet for 12 weeks prior to mating, and throughout pregnancy and lactation. Offspring were weaned onto the control diet and were killed at 12 and 24 weeks of age...
2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28365703/in-vivo-imaging-of-the-cerebral-endothelial-glycocalyx-in-mice
#12
Jin-Hui Yoon, Eek-Sung Lee, Yong Jeong
BACKGROUND/AIMS: Endothelial glycocalyx refers to the proteoglycan or glycoprotein layer of vessel walls and has critical physiological functions. Cerebral glycocalyx may have additional functions considering the blood-brain barrier and other features. However, the assessment of it has only been performed ex vivo, which includes processes presumably damaging the glycocalyx layer. Here we visualize and characterize the cerebral endothelial glycocalyx in vivo. METHODS: We visualized and quantified the cerebral endothelial glycocalyx in vivo under a 2-photon microscope by tagging glycocalyx and vessel lumen with wheat germ agglutinin lectin and dextran, respectively...
2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28365690/changes-in-ip3-receptor-expression-and-function-in-aortic-smooth-muscle-of-atherosclerotic-mice
#13
Marie-Ann Ewart, Azizah Ugusman, Anisha Vishwanath, Tarek A M Almabrouk, Husam Alganga, Omar J Katwan, Pavlina Hubanova, Susan Currie, Simon Kennedy
Peroxynitrite is an endothelium-independent vasodilator that induces relaxation via membrane hyperpolarization. The activation of IP3 receptors triggers the opening of potassium channels and hyperpolarization. Previously we found that relaxation to peroxynitrite was maintained during the development of atherosclerosis due to changes in the expression of calcium-regulatory proteins. In this study we investigated: (1) the mechanism of peroxynitrite-induced relaxation in the mouse aorta, (2) the effect of atherosclerosis on relaxation to peroxynitrite and other vasodilators, and (3) the effect of atherosclerosis on the expression and function of the IP3 receptor...
2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28334715/potassium-channel-independent-relaxing-influence-of-adipose-tissue-on-mouse-carotid-artery
#14
COMPARATIVE STUDY
Marta Laskowski, Cathrin Andersson, Emilie Eliasson, Veronika Golubinskaya, Holger Nilsson
Since the cardiovascular consequences of obesity reportedly vary in different types of obesity, we investigated the influence of adipose tissue from different locales on the phenylephrine-induced tone of the mouse carotid artery. Vessels were mounted in a Mulvany-Halpern-type wire myograph, and adipose tissue, from the back (brown) or mesenteric or inguinal subcutaneous (white), was placed around the artery. Contractile responses to phenylephrine were not affected by brown adipose tissue but were reduced (p < 0...
2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28288470/circulating-concentrations-of-adipocytokines-and-their-receptors-in-the-isolated-corpus-cavernosum-and-femoral-artery-from-trained-rats-on-a-high-fat-diet
#15
Amanda C S Sponton, Fábio H Silva, Hygor N Araujo, Carmem P Valgas da Silva, Camila de Moraes, Edson Antunes, Angelina Zanesco, Maria A Delbin
BACKGROUND: The aim of the present study was to evaluate different signaling pathways by which exercise training would interfere in endothelial function in obesity. Therefore, we examined adipocytokine levels and their receptors in the corpus cavernosum and femoral artery from trained rats on a high-fat diet. METHODS: Functional experiments were performed in control sedentary and trained rats, and sedentary (h-SD) and trained male Wistar rats on a high-fat diet (h-TR)...
2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28122380/dysregulation-of-vascular-endothelial-growth-factor-receptor-2-by-multiple-mirnas-in-endothelial-colony-forming-cells-of-coronary-artery-disease
#16
Shu-Han Su, Chun-Hsien Wu, Ya-Lin Chiu, Shing-Jyh Chang, Hung-Hao Lo, Ko-Hsun Liao, Cheng-Fong Tsai, Tsung-Neng Tsai, Chi-Hung Lin, Shu-Meng Cheng, Cheng-Chung Cheng, Hsei-Wei Wang
BACKGROUND/AIMS: Endothelial colony-forming cells (ECFCs) have the potential to be used in regenerative medicine. Dysfunction of ECFCs is correlated with the onset of cardiovascular disorders, especially coronary artery disease (CAD). Binding of vascular endothelial growth factor A (VEGFA) to vascular endothelial growth factor receptor-2 (VEGFR2) triggers cell motility and angiogenesis of ECFCs, which are crucial to vascular repair. METHODS: To identify the miRNA-VEGFR2-dependent regulation of ECFC functions, ECFCs isolated from peripheral blood of disease-free and CAD individuals were subjected to small RNA sequencing for identification of anti-VEGFR2 miRNAs...
2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28118639/cables1-inhibits-proliferation-and-induces-senescence-by-angiotensin-ii-via-a-p21-dependent-pathway-in-human-umbilical-vein-endothelial-cells
#17
Zhongyue Pu, Yongshun Wang, Xinxin Liu, Jingjin Liu, Jinjin Cui, Yan Wang, Bo Lv, Bo Yu
Cables1 (Cdk5 and Abl enzyme substrate 1) is a vital cell cycle regulator and a candidate tumor suppressor that negatively regulates cell growth by inhibiting cyclin-dependent kinases. Here, we report on the critical role of the Cables1/p21 pathway, which inhibits cell proliferation and induces cell senescence in human umbilical vein endothelial cells. Moreover, we confirmed that silencing of Cables1 promoted cell proliferation as well as increased resistance to angiotensin II-induced senescence, at least in part, by altering Cables1 activation...
2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28095372/impaired-mitochondrial-respiration-in-large-cerebral-arteries-of-rats-with-type-2-diabetes
#18
Ivan Merdzo, Ibolya Rutkai, Venkata N L R Sure, Catherine A McNulty, Prasad V G Katakam, David W Busija
Mitochondrial dysfunction has been suggested as a potential underlying cause of pathological conditions associated with type 2 diabetes (T2DM). We have previously shown that mitochondrial respiration and mitochondrial protein levels were similar in the large cerebral arteries of insulin-resistant Zucker obese rats and their lean controls. In this study, we extend our investigations into the mitochondrial dynamics of the cerebral vasculature of 14-week-old Zucker diabetic fatty obese (ZDFO) rats with early T2DM...
2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28142145/erratum
#19
(no author information available yet)
No abstract text is available yet for this article.
2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/28099964/advancing-age-decreases-pressure-sensitive-modulation-of-calcium-signaling-in-the-endothelium-of-intact-and-pressurized-arteries
#20
COMPARATIVE STUDY
Calum Wilson, Christopher D Saunter, John M Girkin, John G McCarron
Aging is the summation of many subtle changes which result in altered cardiovascular function. Impaired endothelial function underlies several of these changes and precipitates plaque development in larger arteries. The endothelium transduces chemical and mechanical signals into changes in the cytoplasmic calcium concentration to control vascular function. However, studying endothelial calcium signaling in larger arteries in a physiological configuration is challenging because of the requirement to focus through the artery wall...
2016: Journal of Vascular Research
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