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Journal of Vascular Research

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https://www.readbyqxmd.com/read/30001541/effects-of-selenium-in-the-microcirculation-of-fructose-fed-hamsters
#1
Raquel Carvalho Castiglione, Carlos M M R Barros, Beatriz C S Boa, Maria das Graças C De Souza, Eliete Bouskela
BACKGROUND AND AIMS: Fructose intake is directly related to vascular dysfunction and it is a risk factor for the development of metabolic and cardiovascular diseases, such as obesity, diabetes, and hypertension. Selenium, a component of antioxidant enzymes, improves hyperglycemia and vascular function in diabetic animals. The aim of this study was to evaluate the effects of dietary selenium supplementation on microcirculatory and metabolic parameters of fructose-fed hamsters. METHODS AND RESULTS: Male hamsters (Mesocricetus auratus) had their drinking water substituted or not by 10% fructose solution for 60 days, during which their microcirculatory function was evaluated in the cheek pouch preparation...
July 12, 2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29996143/no-protective-effect-of-constitutive-activation-of-ampk-in-endothelial-cells-on-vascular-function-in-aged-obese-mice-but-augmented-%C3%AE-1-adrenergic-contractions-in-renal-arteries-reversible-by-weight-loss
#2
Oliver Baretella, Aimin Xu, Paul M Vanhoutte
BACKGROUND: Aging, obesity, and diabetes favor vascular dysfunction. Endothelial activation of adenosine monophosphate-activated protein kinase (AMPK) has protective effects in diabetes. METHODS: Mice with constitutive endothelial activation of AMPK (CA-AMPK) were given a high fat diet to induce obesity or kept on standard chow as lean controls for up to 2 years. A subset of obese animals was changed to standard chow after 30 weeks of high fat feeding. En-dothelium-dependent and endothelium-independent responses were examined by isometric tension recording...
July 11, 2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29975955/a-simple-method-for-normalization-of-aortic-contractility
#3
Lexiao Jin, Alexandra Lipinski, Daniel J Conklin
Vascular contractile function changes in proliferative vascular diseases, e.g. atherosclerosis, and is documented using isolated blood vessels; yet, many laboratories differ in their approach to quantification. Some use raw values (e.g., mg, mN); others use a "percentage of control agonist" approach; and others normalize by blood vessel characteristic, e.g. length, mass, etc. A lack of uniformity limits direct comparison of contractility outcomes. To address this limitation, we developed a simple 2-step normalization method: (1) measure blood vessel segment length (mm), area (mm2) and calculate volume (mm3); then, (2) normalize isometric contraction (mN) by segment length and volume...
July 5, 2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29972829/astragaloside-iv-improves-vasodilatation-function-by-regulating-the-pi3k-akt-enos-signaling-pathway-in-rat-aorta-endothelial-cells
#4
Xiang-Ping Lin, Han-Jin Cui, A-Li Yang, Jie-Kun Luo, Tao Tang
Coronary heart disease (CHD) remains a major public health burden. Endothelial-dependent coronary artery vasoreactivity is a significant indicator of vascular function. Endothelial dysfunction is characterized by decreased nitric oxide (NO) bioavailability and predicts late cardiovascular events. Astragaloside IV (AGIV) is the main active component of the herb Astragalus membranaceus. Although it shows a significant protective effect against vascular endothelial dysfunction, the mechanisms of AGIV promoting the vascular dilation have not been elucidated...
July 4, 2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29936502/%C3%AE-adrenoceptor-blockade-for-infantile-hemangioma-therapy-do-%C3%AE-3-adrenoceptors-play-a-role
#5
REVIEW
Carlos E Escarcega González, Abimael González Hernández, Carlos M Villalón, Martin G Rodríguez, Bruno A Marichal Cancino
Infantile hemangiomas (IH) are frequent (4-5% of the childhood population) benign vascular tumors that involve accumulation, proliferation, and differentiation of aberrant vascular cells. Typically, IH are innocuous and spontaneously disappear, but they represent a potential risk for harmful effects in the body (e.g., permanent disfigurement) and health (e.g., ulcerations) in some patients. From a serendipitous discovery, the nonselective β-adrenoceptor blocker propranolol (which blocks β1-adrenoceptors, β2-adrenoceptors, and β3-adrenoceptors) emerged as an alternative therapy to treat this pathology and it quickly became a first-line treatment for IH...
June 22, 2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29886482/differential-stiffening-between-the-abdominal-and-thoracic-aorta-effect-of-salt-loading-in-stroke-prone-hypertensive-rats
#6
George Lindesay, Yvonnick Bézie, Christophe Ragonnet, Véronique Duchatelle, Chandima Dharmasena, Nicole Villeneuve, Christine Vayssettes-Courchay
Central artery stiffening is recognized as a cardiovascular risk. The effects of hypertension and aging have been shown in human and animal models but the effect of salt is still controversial. We studied the effect of a high-salt diet on aortic stiffness in salt-sensitive spontaneously hypersensitive stroke-prone rats (SHRSP). Distensibility, distension, and β-stiffness were measured at thoracic and abdominal aortic sites in the same rats, using echotracking recording of the aortic diameter coupled with blood pressure (BP), in SHRSP-salt (5% salted diet, 5 weeks), SHRSP, and normotensive Wistar-Kyoto (WKY) rats...
June 8, 2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29779031/a-novel-ex-vivo-mouse-mesometrium-culture-model-for-investigating-angiogenesis-in-microvascular-networks
#7
Ariana D Suarez-Martinez, Susanne Bierschenk, Katie Huang, Dana Kaplan, Carolyn L Bayer, Stryder M Meadows, Markus Sperandio, Walter L Murfee
BACKGROUND: The development of models that incorporate intact microvascular networks enables the investigation of multicellular dynamics during angiogenesis. Our laboratory introduced the rat mesentery culture model as such a tool, which would be enhanced with mouse tissue. Since mouse mesentery is avascular, an alternative is mouse mesometrium, the connective tissue of uterine horns. The study's objective was to demonstrate that mouse mesometrium contains microvascular networks that can be cultured to investigate multicellular dynamics during angiogenesis...
May 18, 2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29779022/intraoperative-incident-dark-field-imaging-of-the-human-peritoneal-microcirculation
#8
Zühre Uz, Arnoud W Kastelein, Dan M J Milstein, Dan Liu, Fadi Rassam, Denise P Veelo, Jan-Paul W R Roovers, Can Ince, Thomas M van Gulik
BACKGROUND/AIMS: This study describes the peritoneal microcirculation, compares quantitative parameters and angioarchitecture to the standard of sublingual microcirculatory assessment, and determines the practical feasibility of this method. METHODS: Incident dark field imaging was performed of the peritoneum and sublingually to determine angioarchitecture, total and perfused vessel density (TVD and PVD), the proportion of perfused vessels (PPV), the microvascular flow index (MFI) and image acquisition time...
May 18, 2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29635231/rankl-inhibits-the-production-of-osteoprotegerin-from-smooth-muscle-cells-under-basal-conditions-and-following-exposure-to-cyclic-strain
#9
Colin Davenport, Emma Harper, Keith D Rochfort, Hannah Forde, Diarmuid Smith, Philip M Cummins
Receptor activator of nuclear factor-κB ligand (RANKL) promotes vascular calcification, while osteoprotegerin (OPG) opposes it by blocking RANKL activity. It remains unclear which vascular cell populations produce and secrete OPG/RANKL. This study characterizes the production of OPG/RANKL from human aortic endothelial and smooth muscle cells (HAECs and HASMCs) under various conditions. HAECs and HASMCs were exposed to inflammatory stimuli (tumor necrosis factor-α or hyperglycemia) or physiological levels of hemodynamic (cyclic) strain...
2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29455203/absence-of-nicotinamide-nucleotide-transhydrogenase-in-c57bl-6j-mice-exacerbates-experimental-atherosclerosis
#10
Aimee E Vozenilek, Matthew Vetkoetter, Jonette M Green, Xinggui Shen, James G Traylor, Ronald L Klein, A Wayne Orr, Matthew D Woolard, David M Krzywanski
BACKGROUND: Mitochondrial reactive oxygen species (ROS) contribute to inflammation and vascular remodeling during atherosclerotic plaque formation. C57BL/6N (6N) and C57BL/6J (6J) mice display distinct mitochondrial redox balance due to the absence of nicotinamide nucleotide transhydrogenase (NNT) in 6J mice. We hypothesize that differential NNT expression between these animals alters plaque development. METHODS: 6N and 6J mice were treated with AAV8-PCSK9 (adeno-associated virus serotype 8/proprotein convertase subtilisin/kexin type 9) virus leading to hypercholesterolemia, increased low-density lipoprotein, and atherosclerosis in mice fed a high-fat diet (HFD)...
2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29444520/remodeling-of-wall-mechanics-and-the-myogenic-mechanism-of-rat-intramural-coronary-arterioles-in-response-to-a-short-term-daily-exercise-program-role-of-endothelial-factors
#11
Mária Szekeres, György L Nádasy, Gabriella Dörnyei, Annamária Szénási, Akos Koller
PURPOSE: Exercise elicits early adaptation of coronary vessels enabling the coronary circulation to respond adequately to higher flow demands. We hypothesized that short-term daily exercise induces biomechanical and functional remodeling of the coronary resistance arteries related to pressure. METHODS: Male rats were subjected to a progressively increasing 4-week treadmill exercise program (over 60 min/day, 1 mph in the final step). In vitro pressure-diameter measurements were performed on coronary segments (119 ± 5 μm in diameter at 50 mm Hg) with microarteriography...
2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29408825/ligand-activated-peroxisome-proliferator-activated-receptor-%C3%AE-attenuates-vascular-oxidative-stress-by-inhibiting-thrombospondin-1-expression
#12
Min Young Ahn, Sun Ah Ham, Taesik Yoo, Won Jin Lee, Jung Seok Hwang, Kyung Shin Paek, Dae-Seog Lim, Sung Gu Han, Chi-Ho Lee, Han Geuk Seo
Thrombospondin-1 (TSP-1) is implicated in vascular diseases associated with oxidative stress, such as abdominal aortic aneurysms, ischemia-reperfusion injury, and atherosclerosis. However, the regulatory mechanisms underlying TSP-1 expression are not fully elucidated. In this study, we found that peroxisome proliferator-activated receptor δ (PPARδ) inhibited oxidative stress-induced TSP-1 expression and migration in vascular smooth muscle cells (VSMCs). Activation of PPARδ by GW501516, a specific ligand for PPARδ, significantly attenuated hydrogen peroxide (H2O2)-induced expression of TSP-1 in VSMCs...
2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29393228/the-effect-of-a-high-fat-diet-on-the-development-of-abdominal-aortic-aneurysm-in-a-vascular-hypoperfusion-induced-animal-model
#13
Keisuke Hashimoto, Hirona Kugo, Hiroki Tanaka, Kazuko Iwamoto, Chie Miyamoto, Tetsumei Urano, Naoki Unno, Kohsuke Hayamizu, Nobuhiro Zaima, Tatsuya Moriyama
Abdominal aortic aneurysm (AAA) is a vascular disease characterized by chronic inflammation in the infrarenal aorta. Most cases of AAA remain asymptomatic until rupture, and the mortality rate of patients with AAA rupture is very high. Currently, the relation between dietary habits and AAA development remains unknown. In this study, we evaluated the effects of a high-fat diet on the development of AAA in a vascular hypoperfusion-induced animal model. The risk of AAA rupture and AAA diameter in the high-fat group significantly increased compared with those in the control group...
2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29301117/cooperative-effects-of-q10-vitamin-d3-and-l-arginine-on-cardiac-and-endothelial-cells
#14
Claudio Molinari, Vera Morsanuto, Simona Polli, Francesca Uberti
This work demonstrates the cooperative effect of Q10, vitamin D3, and L-arginine on both cardiac and endothelial cells. The effects of Q10, L-arginine, and vitamin D3 alone or combined on cell viability, nitric oxide, and reactive oxygen species productions in endothelial and cardiac cells were studied. Moreover, the involvement of PI3K/Akt and ERK/MAPK pathways leading to eNOS activation as well as the involvement of vitamin D receptor were also investigated. The same agents were tested in an animal model to verify vasodilation, nitric oxide, and reactive oxygen species production...
2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29232676/progressive-development-of-aberrant-smooth-muscle-cell-phenotype-in-abdominal-aortic-aneurysm-disease
#15
Kirsten Riches, Emily Clark, Rebecca J Helliwell, Timothy G Angelini, Karen E Hemmings, Marc A Bailey, Katherine I Bridge, D Julian A Scott, Karen E Porter
Abdominal aortic aneurysm (AAA) is a silent, progressive disease with a high mortality and an increasing prevalence with aging. Smooth muscle cell (SMC) dysfunction contributes to gradual dilatation and eventual rupture of the aorta. Here we studied phenotypic characteristics in SMC cultured from end-stage human AAA (≥5 cm) and cells cultured from a porcine carotid artery (PCA) model of early and end-stage aneurysm. Human AAA-SMC presented a secretory phenotype and expressed elevated levels of the differentiation marker miR-145 (2...
2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29216632/perturbations-in-endothelial-dysfunction-associated-pathways-in-the-nitrofen-induced-congenital-diaphragmatic-hernia-model
#16
Siqin Zhaorigetu, Henry Bair, Jonathan Lu, Di Jin, Scott D Olson, Matthew T Harting
Although it is well known that nitrofen induces congenital diaphragmatic hernia (CDH), including CDH-associated lung hypoplasia and pulmonary hypertension (PH) in rodents, the mechanism of pathogenesis remains largely unclear. It has been reported that pulmonary artery (PA) endothelial cell (EC) dysfunction contributes to the development of PH in CDH. Thus, we hypothesized that there is significant alteration of endothelial dysfunction-associated proteins in nitrofen-induced CDH PAs. Pregnant SD rats received either nitrofen or olive oil on gestational day 9...
2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29197873/comparative-anti-platelet-profiling-reveals-a-potent-anti-aggregatory-effect-of-cd34-progenitor-cell-derived-late-outgrowth-endothelial-cells-in-vitro
#17
COMPARATIVE STUDY
Vasileios G Chantzichristos, Fani Gkrozou, Konstantinos Stellos, Minas E Paschopoulos, Alexandros D Tselepis
BACKGROUND/AIMS: Platelets affect endothelial progenitor cell (EPC) functionality, inducing their differentiation into mature endothelial cells. However, it remains to be established whether EPCs can influence platelet functionality. METHODS: Mononuclear proangiogenic cells (MPCs) and early outgrowth cells (EOCs) were prepared from peripheral blood mononuclear cells, whereas late-outgrowth endothelial cells (OECs) were prepared from cord blood CD34+ cells. The effect of the above cells and their supernatants on washed platelet aggregation was studied...
2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29166645/angiotensin-ii-infusion-does-not-cause-abdominal-aortic-aneurysms-in-apolipoprotein-e-deficient-rats
#18
Evan H Phillips, Mandy S Chang, Sydney Gorman, Hamna J Qureshi, Karin F K Ejendal, Tamara L Kinzer-Ursem, A Nicole Blaize, Craig J Goergen
The apolipoprotein E-deficient (apoE-/-) mouse model has advanced our understanding of cardiovascular disease mechanisms and experimental therapeutics. This spontaneous model recapitulates aspects of human atherosclerosis, and allows for the development of dissecting abdominal aortic aneurysms (AAAs) when combined with angiotensin II. We characterized apoE-/- rats and hypothesized that, similar to mice, they would develop dissecting AAAs. We created rats with a 16-bp deletion of the apoE gene using transcription activator-like effector nucleases...
2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29166642/effect-of-calcium-infiltrated-hydroxyapatite-scaffolds-on-the-hematopoietic-fate-of-human-umbilical-vein-endothelial-cells
#19
Qinghao Zhang, Jörg C Gerlach, Eva Schmelzer, Ian Nettleship
Foamed hydroxyapatite offers a three-dimensional scaffold for the development of bone constructs, mimicking perfectly the in vivo bone structure. In vivo, calcium release at the surface is assumed to provide a locally increased gradient supporting the maintenance of the hematopoietic stem cells niche. We fabricated hydroxyapatite scaffolds with high surface calcium concentration by infiltration, and used human umbilical vein endothelial cells (HUVECs) as a model to study the effects on hematopoietic lineage direction...
2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/29136627/toll-like-receptor-4-reduces-occludin-and-zonula-occludens-1-to-increase-retinal-permeability-both-in-vitro-and-in-vivo
#20
Li Liu, Youde Jiang, Jena J Steinle
We reported that β-adrenergic receptors regulate toll-like receptor 4 (TLR4) signaling in the retina of diabetic mice and in retinal endothelial cells (REC) and Müller cells. We hypothesized that TLR4 regulates retinal permeability both in vitro and in vivo in the retinal vasculature. We used REC cultured in normal and high-glucose conditions and TLR4 siRNA treatments for cell culture studies of permeability and protein analyses of tumor necrosis factor α, occludin, and zonula occludens 1 (ZO-1). We used endothelial cell (EC)-specific Cre-Lox TLR4 knockout mice to study retinal permeability and neuronal and vascular changes following exposure to ocular ischemia/reperfusion (I/R) used as a retinal stressor...
2017: Journal of Vascular Research
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