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Journal of Vascular Research

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https://www.readbyqxmd.com/read/28407626/exogenous-mirna-146a-enhances-the-therapeutic-efficacy-of-human-mesenchymal-stem-cells-by-increasing-vascular-endothelial-growth-factor-secretion-in-the-ischemia-reperfusion-injured-heart
#1
Hyang-Hee Seo, Se-Yeon Lee, Chang Youn Lee, Ran Kim, Pilseog Kim, Sekyung Oh, Hojin Lee, Min Young Lee, Jongmin Kim, Lark Kyun Kim, Ki-Chul Hwang, Woochul Chang
Adult stem cells have been studied as a promising therapeutic modality for the functional restoration of the damaged heart. In the present study, a strategy for enhancing the angiogenic efficacy of human mesenchymal stem cells (hMSCs) using micro-RNA was examined. We investigated whether micro-RNA-146a (miR-146a) influences the secretion of vascular endothelial growth factor (VEGF) and angiogenesis of MSCs. Our data indicated that miR-146a-transfected hMSCs (hMSCmiR-146a) decreased the expression of neurofibromin 2, an inhibitor of p21-activated kinase-1 (PAK1)...
April 14, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28402977/molecular-mechanisms-leading-to-splanchnic-vasodilation-in-liver-cirrhosis
#2
Marco Di Pascoli, David Sacerdoti, Patrizia Pontisso, Paolo Angeli, Massimo Bolognesi
In liver cirrhosis, portal hypertension is a consequence of enhanced intrahepatic vascular resistance and portal blood flow. Significant vasodilation in the arterial splanchnic district is crucial for an increase in portal flow. In this pathological condition, increased levels of circulating endogenous vasodilators, including nitric oxide, prostacyclin, carbon monoxide, epoxyeicosatrienoic acids, glucagon, endogenous cannabinoids, and adrenomedullin, and a decreased vascular response to vasoconstrictors are the main mechanisms underlying splanchnic vasodilation...
April 13, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28376507/the-role-of-o-glcnacylation-in-perivascular-adipose-tissue-dysfunction-of-offspring-of-high-fat-diet-fed-rats
#3
Karolina E Zaborska, Gillian Edwards, Clare Austin, Mark Wareing
Perivascular adipose tissue (PVAT), which reduces vascular contractility, is dysfunctional in the male offspring of rats fed a high-fat diet (HFD), partially due to a reduced NO bioavailability. O-GlcNAcylation of eNOS decreases its activity, thus we investigated the role of O-GlcNAcylation in the prenatal programming of PVAT dysfunction. Female Sprague-Dawley rats were fed either a control (10% fat) or an obesogenic HFD (45% fat) diet for 12 weeks prior to mating, and throughout pregnancy and lactation. Offspring were weaned onto the control diet and were killed at 12 and 24 weeks of age...
April 4, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28365703/in-vivo-imaging-of-the-cerebral-endothelial-glycocalyx-in-mice
#4
Jin-Hui Yoon, Eek-Sung Lee, Yong Jeong
BACKGROUND/AIMS: Endothelial glycocalyx refers to the proteoglycan or glycoprotein layer of vessel walls and has critical physiological functions. Cerebral glycocalyx may have additional functions considering the blood-brain barrier and other features. However, the assessment of it has only been performed ex vivo, which includes processes presumably damaging the glycocalyx layer. Here we visualize and characterize the cerebral endothelial glycocalyx in vivo. METHODS: We visualized and quantified the cerebral endothelial glycocalyx in vivo under a 2-photon microscope by tagging glycocalyx and vessel lumen with wheat germ agglutinin lectin and dextran, respectively...
April 1, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28365690/changes-in-ip3-receptor-expression-and-function-in-aortic-smooth-muscle-of-atherosclerotic-mice
#5
Marie-Ann Ewart, Azizah Ugusman, Anisha Vishwanath, Tarek A M Almabrouk, Husam Alganga, Omar J Katwan, Pavlina Hubanova, Susan Currie, Simon Kennedy
Peroxynitrite is an endothelium-independent vasodilator that induces relaxation via membrane hyperpolarization. The activation of IP3 receptors triggers the opening of potassium channels and hyperpolarization. Previously we found that relaxation to peroxynitrite was maintained during the development of atherosclerosis due to changes in the expression of calcium-regulatory proteins. In this study we investigated: (1) the mechanism of peroxynitrite-induced relaxation in the mouse aorta, (2) the effect of atherosclerosis on relaxation to peroxynitrite and other vasodilators, and (3) the effect of atherosclerosis on the expression and function of the IP3 receptor...
April 1, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28334715/potassium-channel-independent-relaxing-influence-of-adipose-tissue-on-mouse-carotid-artery
#6
Marta Laskowski, Cathrin Andersson, Emilie Eliasson, Veronika Golubinskaya, Holger Nilsson
Since the cardiovascular consequences of obesity reportedly vary in different types of obesity, we investigated the influence of adipose tissue from different locales on the phenylephrine-induced tone of the mouse carotid artery. Vessels were mounted in a Mulvany-Halpern-type wire myograph, and adipose tissue, from the back (brown) or mesenteric or inguinal subcutaneous (white), was placed around the artery. Contractile responses to phenylephrine were not affected by brown adipose tissue but were reduced (p < 0...
2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28288470/circulating-concentrations-of-adipocytokines-and-their-receptors-in-the-isolated-corpus-cavernosum-and-femoral-artery-from-trained-rats-on-a-high-fat-diet
#7
Amanda C S Sponton, Fábio H Silva, Hygor N Araujo, Carmem P Valgas da Silva, Camila de Moraes, Edson Antunes, Angelina Zanesco, Maria A Delbin
BACKGROUND: The aim of the present study was to evaluate different signaling pathways by which exercise training would interfere in endothelial function in obesity. Therefore, we examined adipocytokine levels and their receptors in the corpus cavernosum and femoral artery from trained rats on a high-fat diet. METHODS: Functional experiments were performed in control sedentary and trained rats, and sedentary (h-SD) and trained male Wistar rats on a high-fat diet (h-TR)...
2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28122380/dysregulation-of-vascular-endothelial-growth-factor-receptor-2-by-multiple-mirnas-in-endothelial-colony-forming-cells-of-coronary-artery-disease
#8
Shu-Han Su, Chun-Hsien Wu, Ya-Lin Chiu, Shing-Jyh Chang, Hung-Hao Lo, Ko-Hsun Liao, Cheng-Fong Tsai, Tsung-Neng Tsai, Chi-Hung Lin, Shu-Meng Cheng, Cheng-Chung Cheng, Hsei-Wei Wang
BACKGROUND/AIMS: Endothelial colony-forming cells (ECFCs) have the potential to be used in regenerative medicine. Dysfunction of ECFCs is correlated with the onset of cardiovascular disorders, especially coronary artery disease (CAD). Binding of vascular endothelial growth factor A (VEGFA) to vascular endothelial growth factor receptor-2 (VEGFR2) triggers cell motility and angiogenesis of ECFCs, which are crucial to vascular repair. METHODS: To identify the miRNA-VEGFR2-dependent regulation of ECFC functions, ECFCs isolated from peripheral blood of disease-free and CAD individuals were subjected to small RNA sequencing for identification of anti-VEGFR2 miRNAs...
2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28118639/cables1-inhibits-proliferation-and-induces-senescence-by-angiotensin-ii-via-a-p21-dependent-pathway-in-human-umbilical-vein-endothelial-cells
#9
Zhongyue Pu, Yongshun Wang, Xinxin Liu, Jingjin Liu, Jinjin Cui, Yan Wang, Bo Lv, Bo Yu
Cables1 (Cdk5 and Abl enzyme substrate 1) is a vital cell cycle regulator and a candidate tumor suppressor that negatively regulates cell growth by inhibiting cyclin-dependent kinases. Here, we report on the critical role of the Cables1/p21 pathway, which inhibits cell proliferation and induces cell senescence in human umbilical vein endothelial cells. Moreover, we confirmed that silencing of Cables1 promoted cell proliferation as well as increased resistance to angiotensin II-induced senescence, at least in part, by altering Cables1 activation...
2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28095372/impaired-mitochondrial-respiration-in-large-cerebral-arteries-of-rats-with-type-2-diabetes
#10
Ivan Merdzo, Ibolya Rutkai, Venkata N L R Sure, Catherine A McNulty, Prasad V G Katakam, David W Busija
Mitochondrial dysfunction has been suggested as a potential underlying cause of pathological conditions associated with type 2 diabetes (T2DM). We have previously shown that mitochondrial respiration and mitochondrial protein levels were similar in the large cerebral arteries of insulin-resistant Zucker obese rats and their lean controls. In this study, we extend our investigations into the mitochondrial dynamics of the cerebral vasculature of 14-week-old Zucker diabetic fatty obese (ZDFO) rats with early T2DM...
2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/27673690/hyperglycemia-and-advanced-glycation-end-products-regulate-mir-126-expression-in-endothelial-progenitor-cells
#11
Yeting Li, Qing Zhou, ChongZhe Pei, Bo Liu, MaoQuan Li, Lu Fang, YingGang Sun, YiGang Li, Shu Meng
BACKGROUND/AIMS: Dysfunction of endothelial progenitor cell (EPCs) contributes to diabetic vascular disease. We reported that downregulated miR-126 in diabetic patients causes EPC dysfunction. The study was designed to investigate how high glucose (HG) and advanced glycation end products (AGEs) regulate miR-126 expression and whether miR-126 mediates the effects of HG and AGEs on EPCs. METHODS: We first tested the effects of glucose (5.5-50 mM) and AGEs at 50-200 mg/l on EPC proliferation and selected HG at 50 mM and AGEs at 50 mg/l for further experiments...
September 28, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27626281/mouse-proepicardium-exhibits-a-sprouting-response-to-exogenous-proangiogenic-growth-factors-in-vitro
#12
Justyna Niderla-Bielińska, Bogdan Ciszek, Ewa Jankowska-Steifer, Aleksandra Flaht-Zabost, Grzegorz Gula, Dorota M Radomska-Leśniewska, Anna Ratajska
Angiogenesis contributes to the generation of the vascular bed but also affects the progression of many diseases, such as tumor growth. Many details of the molecular pathways controlling angiogenesis are still undefined due to the lack of appropriate models. We propose the proepicardial explant as a suitable model for studying certain aspects of angiogenesis. The proepicardium (PE) is a transient embryonic structure that contains a population of undifferentiated endothelial cells (ECs) forming a vascular net continuous with the sinus venosus...
September 15, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27577886/minimally-modified-ldl-induced-impairment-of-endothelium-dependent-relaxation-in-small-mesenteric-arteries-of-mice
#13
Gen Chen, Jun-Jie Wang, Cang-Bao Xu, Lei Cao, Jie Lin, Xu-Ping Qing, Si-Yu Liu, En-Qi Liu, Jie Li
Minimally modified low-density lipoprotein (mmLDL) is a well-known risk factor for cardiovascular diseases. The present study was designed to investigate the role of mmLDL in the endothelium-dependent relaxation of mouse mesenteric arteries. A sensitive myograph system was employed to examine the endothelial function of mesenteric arteries. mRNA and protein expression levels were determined using real-time PCR and Western blotting, respectively. The ultramicrostructure of mesenteric vascular beds was investigated using a transmission electron microscope...
September 1, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27532120/extra-and-intraluminal-elastase-induce-morphologically-distinct-abdominal-aortic-aneurysms-in-mice-and-thus-represent-specific-subtypes-of-human-disease
#14
Albert Busch, Amina Holm, Nicole Wagner, Süleyman Ergün, Mathias Rosenfeld, Christoph Otto, Johannes Baur, Richard Kellersmann, Udo Lorenz
Topical application of elastase to induce arterial aneurysm formation is an emerging murine model of vascular disease. In the context of aortic abdominal aneurysm (AAA), angiotensin II infusion and porcine pancreatic elastase perfusion models are commonly used today. This study, therefore, compares matrix remodeling, inflammation, and angiogenesis as distinct features of aneurysms in two models treated with intra-/extraluminal elastase. C57BL/6 mice underwent intra-/extraluminal elastase application via laparotomy and were followed up for 4 weeks...
August 18, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27487299/c-reactive-protein-and-inflammatory-cytokines-during-percutaneous-coronary-intervention
#15
Mingxin Wu, Xinyuan Gu, Xiujuan Li, Yanhui Li, Huaineng Zhou, Guihua Lu, ZhongKai Wu, He Huang, Lilong Tang, Jianping Zeng
BACKGROUND: C-reactive protein (CRP) is significantly associated with cardiovascular diseases; however, whether CRP plays a causal role in coronary artery disease has yet to be determined. In addition, the relationship between CRP, atherosclerosis, and inflammation remains controversial. METHODS AND RESULTS: Serum interleukin (IL)-6, IL-1β, and CRP levels were determined in 160 patients at time points around percutaneous coronary intervention (PCI) with drug-eluting stent implantation...
August 4, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27372431/increment-of-hfabp-level-in-coronary-artery-in-stent-restenosis-segments-in-diabetic-and-nondiabetic-minipigs-hfabp-overexpression-promotes-multiple-pathway-related-inflammation-growth-and-migration-in-human-vascular-smooth-muscle-cells
#16
Kang Chen, Qiu Jing Chen, Ling Jie Wang, Zhu Hui Liu, Qi Zhang, Ke Yang, Hai Bo Wang, Xiao Xiang Yan, Zhen Bin Zhu, Run Du, Rui Yan Zhang, Wei Feng Shen, Lin Lu
BACKGROUND: Our previous study suggested that heart-type fatty acid-binding protein (HFABP) levels were greatly elevated in the conditioned medium of explant culture of in-stent restenosis (ISR) tissue from diabetic minipigs compared with those of non-ISR tissue. We here verified this result in animal tissues and investigated the impact of HFABP overexpression in human aortic smooth muscle cells (hASMCs). METHODS AND RESULTS: In Western blot and real-time RT-PCR, HFABP protein and mRNA levels were significantly higher in ISR than in non-ISR tissues from minipigs, and higher in the ISR tissue from diabetic minipigs than that from nondiabetic minipigs...
July 2, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27344146/altered-pparx03b3-coactivator-1-alpha-expression-in-abdominal-aortic-aneurysm-possible-effects-on-mitochondrial-biogenesis
#17
Marike Gabrielson, Emina Vorkapic, Maggie Folkesson, Martin Welander, Andreas Matussek, Jan Dimberg, Toste Länne, Josefin Skogberg, Dick Wågsäter
INTRODUCTION: Abdominal aortic aneurysm (AAA) is a complex and deadly vascular disorder. The pathogenesis of AAA includes destruction and phenotypic alterations of the vascular smooth muscle cells (VSMCs) and aortic tissues. PPARx03B3; coactivator-1 alpha (PGC1α) regulates VSMC migration and matrix formation and is a major inducer of mitochondrial biogenesis and function, including oxidative metabolism. METHODS: Protein and gene expression of PGC1α and markers for mitochondria biogenesis and cell type-specificity were analysed in AAA aortas from humans and mice and compared against control aortas...
June 25, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27327039/multidimensional-contribution-of-matrix-metalloproteinases-to-atherosclerotic-plaque-vulnerability-multiple-mechanisms-of-inhibition-to-promote-stability
#18
Jean Marie Ruddy, John S Ikonomidis, Jeffrey A Jones
The prevalence of atherosclerotic disease continues to increase, and despite significant reductions in major cardiovascular events with current medical interventions, an additional therapeutic window exists. Atherosclerotic plaque growth is a complex integration of cholesterol penetration, inflammatory cell infiltration, vascular smooth muscle cell (VSMC) migration, and neovascular invasion. A family of matrix-degrading proteases, the matrix metalloproteinases (MMPs), contributes to all phases of vascular remodeling...
June 22, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/28142145/erratum
#19
(no author information available yet)
No abstract text is available yet for this article.
2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/28099964/advancing-age-decreases-pressure-sensitive-modulation-of-calcium-signaling-in-the-endothelium-of-intact-and-pressurized-arteries
#20
Calum Wilson, Christopher D Saunter, John M Girkin, John G McCarron
Aging is the summation of many subtle changes which result in altered cardiovascular function. Impaired endothelial function underlies several of these changes and precipitates plaque development in larger arteries. The endothelium transduces chemical and mechanical signals into changes in the cytoplasmic calcium concentration to control vascular function. However, studying endothelial calcium signaling in larger arteries in a physiological configuration is challenging because of the requirement to focus through the artery wall...
2016: Journal of Vascular Research
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