Elizabeth C Young, Martina M Owens, Idowu Adebiyi, Tina Bedenham, Rachel Butler, Jonathan Callaway, Treena Cranston, Charlene Crosby, Ian A Cree, Laura Dutton, Catherine Faulkes, Claire Faulkner, Emma Howard, Julia Knight, Yuanxue Huang, Louise Lavender, Lazarus P Lazarou, Hongxiang Liu, Debbie Mair, Antonio Milano, Stacey Sandell, Alison Skinner, Andrew Wallace, Maggie Williams, Vicky Spivey, John Goodall, Jonathan Frampton, Sian Ellard
EGFR mutation testing of tumor samples is routinely performed to predict sensitivity to treatment with tyrosine kinase inhibitors for patients with non-small cell lung cancer. At least 9 different methodologies are employed in UK laboratories, and the aim of this study was to compare the sensitivity of different methods for the detection of EGFR mutations. Participating laboratories were sent coded samples with varying mutation loads (from 0% to 15%) to be tested for the p.Leu858Arg (p.L858R) missense mutation and c...
December 2013: Diagnostic Molecular Pathology: the American Journal of Surgical Pathology, Part B