Adriana Metoni, Cristina Mambet, Laura G Necula, Ioana M Aldea, Ana I Neagu, Lilia Matei, Denisa Dragu, Coralia Bleotu, Daniela A Ion, Carmen C Diaconu
Thrombotic events are highly prevalent in systemic lupus erythematosus (SLE). Antiphospholipid antibodies play an essential role in promoting thrombosis by activating several intracellular signaling pathways (TLR4, p38MAPK, NFkB) in platelets, monocytes and endothelial cells. New therapeutic opportunities might be offered by addressing these molecular targets. Chronic inflammatory status, the degree of disease activity and accelerated atherosclerosis are also responsible for the thrombotic phenotype in patients with SLE...
July 2014: Roumanian Archives of Microbiology and Immunology