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Journals Roumanian Archives of Microbio...

Roumanian Archives of Microbiology and Immunology

https://read.qxmd.com/read/26727850/genomic-analysis-of-hepatitis-b-virus-strains-infecting-romanian-patients
#21
JOURNAL ARTICLE
Sorin Dinu, Graţiela Târdei, Emanoil Ceausu, Adriana Moţoc, Cristiana Oprea, Eugenia Ungureanu, Luminiţa Ene, Dan Duiculescu, Dana Brehar Cioflec, Gabriela Oprişan
Chronic hepatitis B is widespread and represents an important cause of morbidity and mortality due to the evolution to cirrhosis and hepatocellular carcinoma. This study was designed to improve the national laboratory surveillance of hepatitis B virus (HBV) infection, focusing on genomic analysis of isolates from Romanian patients. Sera from ten patients with HBV were collected and analyzed. Phylogenetic analysis was conducted on a DNA fragment spanning almost the entire genome. The occurrence of mutations was assessed for each open reading frame in the viral genome...
January 2015: Roumanian Archives of Microbiology and Immunology
https://read.qxmd.com/read/26727849/screening-of-protease-inhibitors-resistance-mutations-in-hepatitis-c-virus-isolates-infecting-romanian-patients-unexposed-to-triple-therapy
#22
JOURNAL ARTICLE
Sorin Dinu, Petre-Iacob Calistru, Emanoil Ceauşu, Graţiela Târdeil, Gabriela Oprişan
Although the European recommendations include the use of new antiviral drugs for the treatment of hepatitis C, in Romania the current treatment remains interferon plus ribavirin. First generation viral protease inhibitors (i.e. boceprevir, telaprevir), which have raised the chances of obtaining viral clearance in up to 70% of infection cases produced by genotype 1 isolates, have not been introduced yet as standard treatment in our country. The success of these new antivirals is limited by the occurrence and selection of resistance mutations during therapy...
January 2015: Roumanian Archives of Microbiology and Immunology
https://read.qxmd.com/read/26727848/in-memoriam-dr-geza-adalbert-szegli-17-january-1929-25-december-2014
#23
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
January 2015: Roumanian Archives of Microbiology and Immunology
https://read.qxmd.com/read/26201126/role-of-salmonella-serology-a-century-after-the-widal-era
#24
JOURNAL ARTICLE
Alexandra-Maria Năşcuţiu
Typhoid fever remains an important health burden in the developing world, whereas non-typhoid salmonelloses are one of the most common food-borne illnesses throughout the world and can be subjected to extra-intestinal complications. Culture is the gold standard for diagnosing a Salmonella infection. Serology can also provide evidence of infection. Serological methods for the diagnosis of Salmonella infections in humans and animals vary widely and can as well be used in epidemiologic studies to detect carriers, to assess infection rates, disease burden and vaccine responses...
July 2014: Roumanian Archives of Microbiology and Immunology
https://read.qxmd.com/read/26201125/romanian-scientists-in-the-nomination-database-for-the-nobel-prize-in-physiology-or-medicine-1901-1951
#25
JOURNAL ARTICLE
Costin Cernescu
Nobelprize.org site is the most reliable and complete resource of information on the Nobel Prize and the Nobel Laureates. The nomination database for Physiology or Medicine, 1901-1951, offers exciting facts about the Romanian Schools of Medicine from Bucharest, Iaşi and Cluj. Between 1920-1950, four Romanian scientists were nominated for the Nobel Prize: Victor Babeş (1854-1926), Ion Cantacuzino (1863-1934), Thoma Ionescu (1860-1926) and Constantin Levaditi (1874-1953). This paper discusses these nominees, the nominators and the motivations, as well as the specific publications that endorse the candidates' scientific activity...
July 2014: Roumanian Archives of Microbiology and Immunology
https://read.qxmd.com/read/26201124/mechanisms-of-thrombosis-in-systemic-lupus-erythematosus
#26
REVIEW
Adriana Metoni, Cristina Mambet, Laura G Necula, Ioana M Aldea, Ana I Neagu, Lilia Matei, Denisa Dragu, Coralia Bleotu, Daniela A Ion, Carmen C Diaconu
Thrombotic events are highly prevalent in systemic lupus erythematosus (SLE). Antiphospholipid antibodies play an essential role in promoting thrombosis by activating several intracellular signaling pathways (TLR4, p38MAPK, NFkB) in platelets, monocytes and endothelial cells. New therapeutic opportunities might be offered by addressing these molecular targets. Chronic inflammatory status, the degree of disease activity and accelerated atherosclerosis are also responsible for the thrombotic phenotype in patients with SLE...
July 2014: Roumanian Archives of Microbiology and Immunology
https://read.qxmd.com/read/26201123/microrna-biogenesis-and-its-role-in-hiv-1-infection
#27
REVIEW
Adelina Roşca, Gabriela Anton, Simona Ruţă
MicroRNA (miRNA) are small- 19-24 nucleotides, non-coding RNA molecules that regulate translational and post-translational processes through mRNA degradation and protein translation repression, or sometimes through heterochromatin formation or activation of protein translation. Lately, miRNA are investigated as predictive biomarkers for the evolution and prognosis of viral diseases, as well as therapeutic targets. Although the role of non-coding RNA molecules during HIV infection is not yet fully elucidated, several studies have reported strong correlations between cellular and viral miRNA expression and the immunologic and virological status of infected patients...
July 2014: Roumanian Archives of Microbiology and Immunology
https://read.qxmd.com/read/26201122/molecular-characterization-of-staphylococcus-aureus-strains-isolated-from-infective-endocarditis
#28
JOURNAL ARTICLE
Mihaela Oprea, David Sebastian Patriche, Monica Străuţ, Felicia Antohe
Infective endocarditis (IE) is an infection of the heart endothelium and valves and is frequently a consequence of a sanguine flow turbulence and injury of endocardium. Recent studies revealed an increase of Staphylococcus aureus strains involved in IE, but no evident correlations between the genetic background of this bacterium and IE involvement of certain strains have been found yet. In this study we analyzed the virulence profile, including adhesins, exotoxins, superantigens and biofilm determinants, along with agr type detection, for S...
July 2014: Roumanian Archives of Microbiology and Immunology
https://read.qxmd.com/read/26201121/serum-alpha-fetoprotein-a-surrogate-marker-for-liver-disease-progression-in-chronic-hepatitis-c
#29
JOURNAL ARTICLE
Camelia Sultana, Claudia Diţă, Alina Botescu, Camelia Grancea, Simona Ruţă
Serum alpha fetoprotein (AFP) is a commonly used marker in the screening for hepatocellular carcinoma. This study aims to evaluate the value of AFP as an early predictor of the evolution of chronic hepatitis C. In a retrospective study on 116 HCV-infected patients (62.9% females, mean age 49.13 ± 1.73 years), increased levels of serum AFP (> 7 ng/mL) were found in 39.7% of cases. High serum AFP levels were more frequently detected in older patients and in those with severe fibrosis and cirrhosis (62.2% and 76...
July 2014: Roumanian Archives of Microbiology and Immunology
https://read.qxmd.com/read/26201120/is-there-a-difference-in-the-incidence-of-helicobacter-pylori-infection-in-patients-with-some-chronic-diseases
#30
JOURNAL ARTICLE
Cristian Adrian Constantinescu, Elena Mihaela Constantinescu
Globally, Helicobacter pylori infection is estimated to be present in two-thirds of the population. This longitudinal, observational, comparative case-control study conducted in the county of Braşov on 763 subjects split into two groups: one with Helicobacter pylori infection (412 people) and the other without infection (351 people) allowed us to compare our results with other international epidemiological studies. Thus, statistical interpretation of results indicates diabetes as an indifferent factor in the interrelation with Helicobacter pylori infection, while asthma and hypertension might be considered as protective factors...
July 2014: Roumanian Archives of Microbiology and Immunology
https://read.qxmd.com/read/25518572/status-of-immunity-against-poliomyelitis-in-the-acute-flaccid-paralysis-afp-cases-in-romania-between-2009-2012
#31
JOURNAL ARTICLE
Anda Băicuş
Poliovirus (PV), a member of the Enterovirus genus, is the etiological agent of poliomyelitis, an acute paralytic disease. No poliovirus strain has been isolated in Romania since 2009. A serosurvey study carried out between 2009-2012, that involved 76 serum samples from acute flaccid paralysis (AFP) cases, showed a low protection level in the examined subjects against type 1 (80%), type 2 (79%) and type 3 (71%) poliovirus Sabin strains. Samples with titers ≥ 1:8 were considered positive. Suboptimal seroprevalence in the AFP cases confirmed that a high level of immunization against polio must be assured in our country, because the risk of importation and subsequent transmission of the poliovirus remains until polio is globally eradicated...
January 2014: Roumanian Archives of Microbiology and Immunology
https://read.qxmd.com/read/25518571/immunological-investigations-in-prostatic-pathology-a-prospective-study
#32
JOURNAL ARTICLE
Dan Spînu, Dan Mischianu, Mihaela Surcel, Radu Huică, Adriana Munteanu, Ioana Pîrvu, Dan Ciotaru, Ovidiu Bratu, Cătălin Farcaş, Ştefan Manache, Cornel Ursaciuc
BACKGROUND: BPH with prostatitis represents one of the most common urological pathologies affecting most men. The etiology of both conditions remains at the discretion of the various assumptions. OBJECTIVES: The body's cellular immune response in prostate adenoma is a less studied aspect which we have focused on, in this paper. The correlation with a wide range of information from specific investigations such as prostate-specific antigen (PSA) and total histopathology was the secondary aim of this work...
January 2014: Roumanian Archives of Microbiology and Immunology
https://read.qxmd.com/read/25518570/kir-genotyping-in-the-selected-population-in-andhra-pradesh-india
#33
JOURNAL ARTICLE
G Vaishnav, S Krupanidhi, C B Sanjeevi
BACKGROUND: The population is not always homogeneous in relation to the representation and functioning of genes. Therefore, the presence of allogenicity is a universal phenomenon. The profound variability is noticed among the members of the human population with reference to the resistance against infections and late onset of diseases. In this line, a few sets of alleles which come under the domain of immune function namely KIRs (Killer immunoglobulin-like receptor genes) and HLA-I have been chosen to report in the population of Puttaparthi (India)...
January 2014: Roumanian Archives of Microbiology and Immunology
https://read.qxmd.com/read/25518569/antimicrobial-and-antioxidant-activities-of-alcoholic-extracts-obtained-from-vegetative-organs-of-a-retroflexus
#34
JOURNAL ARTICLE
Ioana Cristina Marinaş, Carmen Chifiriuc, Eliza Oprea, Veronica Lazăr
In vitro antimicrobial and antioxidant activities of Amaranthus retroflexus leaves and inflorescence alcoholic (ethanol 70%) extracts of various concentrations ranging from 0.78 to 400 μL/ml were analyzed on different clinical and reference bacterial strains (Staphylococcus aureus, Bacillus subtills, Enterococcus faecalis, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii) and fungal strains (Candida albicans, C. famata, C. utilis, Saccharomyces cerevisiae) using agar disk diffusion method and broth dilution method (MIC determination) for antimicrobial activity and TEAC (Trolox capacity) assay for the evaluation of the antioxidant activity...
January 2014: Roumanian Archives of Microbiology and Immunology
https://read.qxmd.com/read/25518568/hematology-references-for-three-laboratory-mice-strains
#35
JOURNAL ARTICLE
Bogdan Marinescu, Gheorghiţa Isvoranu, Laurenţiu Anghelache, Florina Cionca
The paper contains reference data for the main haematologic indicators from three strains of conventional mice: Balb/c, C57BL/6 and CD1. These data listed include the mean and the standard deviation of the studied values. The animals used were divided by sex (sex ratio 1:1) and age. The study was performed in standard conditions. These strains were chosen as they are widely used for preclinical evaluations. Therefore, our data are expected to be useful for investigators conducting qualitative and quantitative toxicity studies in these mice...
January 2014: Roumanian Archives of Microbiology and Immunology
https://read.qxmd.com/read/25518567/differentiation-of-influenza-b-lineages-from-clinical-samples-by-one-step-real-time-rt-pcr
#36
JOURNAL ARTICLE
Carmen Maria Cherciu, Gheorghe Necula, Maria Elena Mihai, Alina Elena Ivanciuc, Mihaela Lazăr, Cristina Ţecu, Daniela Piţigoi, Emilia Lupulescu
BACKGROUND: Influenza viruses type A and type B are a leading cause of annual epidemics in human populations. Since the 1970s, influenza B viruses have diverged into two antigenically distinct virus lineages called the Yamagata and Victoria lineages. We describe the validation and implementation of a one-step real-time RT-PCR (rRT-PCR) assay that can differentiate between the two genetic lineages of type B. METHODS: Validation of rRT-PCR method was carried out using quantified positive control and reference influenza viruses with specific minor groove binder (MGB) probes...
January 2014: Roumanian Archives of Microbiology and Immunology
https://read.qxmd.com/read/25518566/seroprevalence-study-of-anti-diphtheria-antibodies-in-two-age-groups-of-romanian-adults
#37
JOURNAL ARTICLE
Cristiana Cerasella Dragomirescu, Ileana-Luminiţa Coldea, Anamaria Ilie, Aurora Stănescu, Vasilica Ungureanu, Mircea Ioan Popa
BACKGROUND: Diphtheria represents a serious infectious disease with high epidemic potential. It is a vaccine preventable disease (a minimum vaccine coverage of 95% for children of 1 year and 90% in adults could prevent the disease). Diphtheria vaccination is included in the National Immunization Program (NIP). Complete vaccination for children consists in DTaP (diphtheria toxoid, tetanus toxoid and acellular pertussis vaccine) vaccine administration from the age of 2 months until 4 years and dT vaccine (tetanus toxoid and a reduced dose of diphtheria toxoid) at 14 years old...
January 2014: Roumanian Archives of Microbiology and Immunology
https://read.qxmd.com/read/25518565/molecular-detection-of-nine-antibiotic-resistance-genes-in-methicillin-resistant-staphylococcus-aureus-isolates
#38
JOURNAL ARTICLE
Ghaleb Adwan, Kamel Adwan, Naser Jarrar, Alaa Amleh
This study aimed to evaluate the relation between the phenotypic antibiotic susceptibility patterns and the antibiotic resistance genes and to investigate the prevalence of macrolide, lincosamides, streptogramin, aminoglycoside and tetracycline resistance genes among MRSA isolates. A total of 55 clinical MRSA isolates were included in this study, antibiotic resistance was conducted by Kirby-Bauer disk diffusion method, broth microdilution assay and multiplex PCR technique. Our results showed that there was no discordance between conventional susceptibility testing and gene detection by multiplex PCR assay...
January 2014: Roumanian Archives of Microbiology and Immunology
https://read.qxmd.com/read/25518564/escherichia-coli-st131-causing-invasive-infections-in-romanian-patients-a-threat-we-can-no-longer-ignore
#39
JOURNAL ARTICLE
Codruţa-Romaniţa Usein, Maria Condei, Dana Cristea, Simona Adriana Ciontea, Dorina Tatu-Chiţoiu, Violeta Cristea, Monica Străuţ
Escherichia coli sequence type ST131 is a major pandemic clonal group of drug-resistant extraintestinal pathogenic E. coli (ExPEC) involved in community-onset and healthcare-associated infections. Thus far, its presence in our area has been paid little attention. This is a preliminary study intended to detect ST131 among 87 clinical isolates retrieved from a larger and unpublished E. coli collection. The study isolates originated from various specimens associated with invasive infections (blood, deep surgical wounds/abscesses, tracheal aspirates, pleural fluid, cerebrospinal fluid, and peritoneal fluid) and were collected between 2010 and 2014...
January 2014: Roumanian Archives of Microbiology and Immunology
https://read.qxmd.com/read/24923109/resveratrol-modulates-apoptosis-in-5-fluorouracyl-treated-colon-cancer-cell-lines
#40
JOURNAL ARTICLE
Dan Hotnog, Mirela Mihăilă, Iulia Virginia Lancu, Georgiana Gabriela Matei, Camelia Hotnog, Gabriela Anton, Marinela Bostan, Lorelei I Braşoveanu
Since cancer is a cellular disease, it is essential to identify the development stages and use the information in the prediction, prevention, early detection and design of drug targets. Colon cancer represents a malignancy with high incidence and mortality throughout the world, its etiology involving many genetic, immunological and biochemical factors. 5-fluorouracyl (5-FU) is one of the most effective anti-cancer agents used in the treatment of colorectal cancers, but tumor chemoresistance is a major limiting factor of its use...
October 2013: Roumanian Archives of Microbiology and Immunology
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