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Roumanian Archives of Microbiology and Immunology

Anahita Sanaei Dashti, Mohammad Reza Alaei, Zahra Musavi, Raheleh Faramarzi, Farhad Mansouri, Amir Nasimfar
OBJECTIVE: Patients with diabetes mellitus (DM) are more susceptible to infections. Deficiency in some domains of immune system could be one of the main reasons, which increases the risk of infections. The aim of this study was to assess antibody responses to vaccines in a group of children with diabetes and in the controls. METHODS: A cross-sectional study was performed among 90 children under 15 years of age with a history of type 1 DM, referred to endocrinology clinics of university hospitals; Mofid Children Hospital and Loghman Hospital...
July 2015: Roumanian Archives of Microbiology and Immunology
Corina-Daniela Ene, Ilinca Nicolae
UNLABELLED: The authors' interest was focused on prolactin status in patients with melanocytic lesions and on changes induced by interferon treatment in melanoma patients. MATERIAL AND METHOD: The study lasted 5 years and included 128 melanoma patients, 48 dysplastic nevi patients and 48 healthy volunteers. Sixty melanoma cases were selected after surgical removal of tumor and divided into 2 groups: 30 patients with 10 MUmp(-1) interferon alpha2b treatment, three times a week, one year and 30 patients without interferon treatment...
July 2015: Roumanian Archives of Microbiology and Immunology
Srirama Krupanidhi
The mammalian conceptus is a semi-allograft. The maternal tolerance towards semi-allograft is primed by a battery of cytokines and resident decidual cells. Invasion of embryonic trophoblast, decidual vascular remodeling and unresponsive incipient 'Triple-negative' (CD3-, CD4- and CD8-) T-cells of foetus promote normal pregnancy. On the other hand, the maternal cytokine profile shift towards Th1 response is shown to enhance the risk during pregnancy. The periodical examination of maternal serum levels of Th1 and Th2 response mediated cytokines constitutes prognostic biomarkers to initiate therapeutic regimens...
July 2015: Roumanian Archives of Microbiology and Immunology
Andreea-Roxana Lupu, Lidia Cremer
In the context of an emerging market of food supplements, the proven quality of the antioxidant products should be the main criteria for using them. The production process has to be carefully controlled and complementary tests are needed to demonstrate the correspondence between real and declared properties of final product. Using well characterized compounds with proven antioxidant activity in biological systems as reference brings a plus of rigorously to the testing protocol. The aim of this study was to determine the acceptance range for the antioxidant (peroxyl radicals scavenger) capacity of "Natural SOD" by using for comparison ascorbic acid (vitamin C)...
July 2015: Roumanian Archives of Microbiology and Immunology
Leila Azimi, Amirmorteza Ebrahimzadeh Namvar, Sadaf Jamali, Aida Rastegar Lari, Aslan Bijari, Abdolaziz Rastegar Lari
Pseudomonas aeruginosa is known as an important opportunistic pathogen, resistant to a high number of antibiotics. Efflux pumps are one of the main intrinsic antibiotics resistance mechanisms in P. aeruginosa. MexAB-OprM, MexCD-OprJ, and MexXY-OprM are the main efflux pumps involved in beta-lactam resistant strains which may cause cross resistance to different antimicrobial classes. The aim of this study was to detect relative gene expression in betalactam-resistant clinical P. aeruginosa strains. One hundred fourteen clinical strains of P...
July 2015: Roumanian Archives of Microbiology and Immunology
Hisham A Abbas
Resistance of Pseudomonas aeruginosa to antibiotics is a major problem. Targeting virulence factors is an alternative option to avoid the emergence of resistance to antibiotics. The effect of sub-inhibitory concentration of diclofenac sodium on the production of virulence factors of P. aeruginosa was investigated. The virulence factors included protease, haemolysin, pyocyanin and pyoverdin, in addition to pathogenic behaviors such as swimming and twitching motilities and biofilm formation. Diclofenac sodium showed significant inhibition of virulence factors as compared to the control...
July 2015: Roumanian Archives of Microbiology and Immunology
Violeta Corina Cristea, Mihaela Oprea, Gabriela Neacşu, Ramona Gîlcă, Mircea Ioan Popa, Codruţa-Romaniţa Usein
Urinary tract infections (UTI) with Escherichia coli are among the most common infections presenting in general practice. Fluoroquinolones (FQs) are relied on for their empirical therapy but recent reports indicate a concerning increase in the percentage of FQ-resistant E. coli isolates in many countries, including Romania. Sixty E. coli strains with ciprofloxacin resistance and cephalosporin susceptibility isolated from urine specimens of non-hospitalized patients during a five-month period (October 2014 - February 2015) were further analyzed to determine the molecular basis of FQ resistance (i...
July 2015: Roumanian Archives of Microbiology and Immunology
Anda Băicuş
Poliovirus (PV), a member of the Enterovirus genus, is the etiological agent of poliomyelitis. A study carried out between 2013-2014 on 30 serum samples from acute flaccid paralysis (AFP) cases, showed a protective antibody level of 90% against poliovirus Sabin strains type 1 and type 2 and of 88% against type 3. No PV strains were isolated from 2009 to 2015 in Romania. Maintaining a high vaccine coverage level against polio is mandatory until global polio eradication, especially as the risk of polio importation remains elevated in Romania...
January 2015: Roumanian Archives of Microbiology and Immunology
Elena-Carmina Drăgulescu, Irina Codiţă
Staphylococcus aureus (S. aureus) is a major cause of hospital-acquired (HA-SA) and community-acquired (CA-SA) infections worldwide. It is isolated from many human body sites, from animals and from foods, from the environment. Pathogenesis is caused by many virulence factors and antibiotic resistance. The host immune system tries to keep under control this pathogen, but many virulence factors produced by this under the regulatory systems control attack the immune system. The epidemiology of S. aureus is in permanent dynamic and is changing quickly...
January 2015: Roumanian Archives of Microbiology and Immunology
Cristian Comănescu, Victoria Aramă, Camelia Grancea, Coralia Bleotu, Mihaela Rădulescu, Cătălin Tilişcan, Anca Botezatu, Gabriela Anton, Simona Ruţă
UNLABELLED: Gingival crevicular fluid (GCF) and saliva samples provide advantages for screening or sero-prevalence studies on HCV using less invasive methods. The study aimed to evaluate the performance of a rapid test for HCV-antibodies (HCV-Ab) screening in oral fluids among high-risk individuals with chronic liver disease. METHODS: Chronic liver disease patients attending at the Matei Bals National Instiute for Infectious Diseases were recruited for this study...
January 2015: Roumanian Archives of Microbiology and Immunology
Iulia V Iancu, Adriana Pleşa, Anca Botezatu, Irina Huică, Anca D Stănescu, Demetra Socolov, Gabriela Anton
Human papilloma virus (HPV) may cause mostly transient infections of cutaneous and mucous epithelia. Persistent HPV genital infections may induce pre-malignant or malignant lesions. While E6 and E7 HPV genes' malignant character is known, E5 is still under debate. We evaluated the possible role of E5 gene in cervix oncogenesis, in patients with abnormal cytology and HPV1 6 positive, in the context of viral status correlated with potential targets (p21, EGFR). HPV DNA was detected and genotyped using Linear Array HPV Genotyping Test (Roche Molecular Biochemicals, Mannheim, Germany) and E2, E6, E5 HPV16, p21 and EGFR transcripts levels were investigated by qRT-PCR...
January 2015: Roumanian Archives of Microbiology and Immunology
Daniela Cristea, Mihaela Oprea, Adriana Simona Ciontea, Codruţa-Romaniţa Usein
Although not endemic in the European Union and European Economic Area, shigellosis is included among the priority food- and waterborne diseases carefully surveyed by the European Centre for Disease Prevention and Control. From 2010 to 2012, 1018 cumulated confirmed shigellosis cases were reported to the European Surveillance System by Romania. This retrospective study aimed to provide insights into the antibiotic resistance and genetic diversity of a set of Shigella sonnei isolates recovered during that period...
January 2015: Roumanian Archives of Microbiology and Immunology
Sorin Dinu, Graţiela Târdei, Emanoil Ceausu, Adriana Moţoc, Cristiana Oprea, Eugenia Ungureanu, Luminiţa Ene, Dan Duiculescu, Dana Brehar Cioflec, Gabriela Oprişan
Chronic hepatitis B is widespread and represents an important cause of morbidity and mortality due to the evolution to cirrhosis and hepatocellular carcinoma. This study was designed to improve the national laboratory surveillance of hepatitis B virus (HBV) infection, focusing on genomic analysis of isolates from Romanian patients. Sera from ten patients with HBV were collected and analyzed. Phylogenetic analysis was conducted on a DNA fragment spanning almost the entire genome. The occurrence of mutations was assessed for each open reading frame in the viral genome...
January 2015: Roumanian Archives of Microbiology and Immunology
Sorin Dinu, Petre-Iacob Calistru, Emanoil Ceauşu, Graţiela Târdeil, Gabriela Oprişan
Although the European recommendations include the use of new antiviral drugs for the treatment of hepatitis C, in Romania the current treatment remains interferon plus ribavirin. First generation viral protease inhibitors (i.e. boceprevir, telaprevir), which have raised the chances of obtaining viral clearance in up to 70% of infection cases produced by genotype 1 isolates, have not been introduced yet as standard treatment in our country. The success of these new antivirals is limited by the occurrence and selection of resistance mutations during therapy...
January 2015: Roumanian Archives of Microbiology and Immunology
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January 2015: Roumanian Archives of Microbiology and Immunology
Alexandra-Maria Năşcuţiu
Typhoid fever remains an important health burden in the developing world, whereas non-typhoid salmonelloses are one of the most common food-borne illnesses throughout the world and can be subjected to extra-intestinal complications. Culture is the gold standard for diagnosing a Salmonella infection. Serology can also provide evidence of infection. Serological methods for the diagnosis of Salmonella infections in humans and animals vary widely and can as well be used in epidemiologic studies to detect carriers, to assess infection rates, disease burden and vaccine responses...
July 2014: Roumanian Archives of Microbiology and Immunology
Costin Cernescu site is the most reliable and complete resource of information on the Nobel Prize and the Nobel Laureates. The nomination database for Physiology or Medicine, 1901-1951, offers exciting facts about the Romanian Schools of Medicine from Bucharest, Iaşi and Cluj. Between 1920-1950, four Romanian scientists were nominated for the Nobel Prize: Victor Babeş (1854-1926), Ion Cantacuzino (1863-1934), Thoma Ionescu (1860-1926) and Constantin Levaditi (1874-1953). This paper discusses these nominees, the nominators and the motivations, as well as the specific publications that endorse the candidates' scientific activity...
July 2014: Roumanian Archives of Microbiology and Immunology
Adriana Metoni, Cristina Mambet, Laura G Necula, Ioana M Aldea, Ana I Neagu, Lilia Matei, Denisa Dragu, Coralia Bleotu, Daniela A Ion, Carmen C Diaconu
Thrombotic events are highly prevalent in systemic lupus erythematosus (SLE). Antiphospholipid antibodies play an essential role in promoting thrombosis by activating several intracellular signaling pathways (TLR4, p38MAPK, NFkB) in platelets, monocytes and endothelial cells. New therapeutic opportunities might be offered by addressing these molecular targets. Chronic inflammatory status, the degree of disease activity and accelerated atherosclerosis are also responsible for the thrombotic phenotype in patients with SLE...
July 2014: Roumanian Archives of Microbiology and Immunology
Adelina Roşca, Gabriela Anton, Simona Ruţă
MicroRNA (miRNA) are small- 19-24 nucleotides, non-coding RNA molecules that regulate translational and post-translational processes through mRNA degradation and protein translation repression, or sometimes through heterochromatin formation or activation of protein translation. Lately, miRNA are investigated as predictive biomarkers for the evolution and prognosis of viral diseases, as well as therapeutic targets. Although the role of non-coding RNA molecules during HIV infection is not yet fully elucidated, several studies have reported strong correlations between cellular and viral miRNA expression and the immunologic and virological status of infected patients...
July 2014: Roumanian Archives of Microbiology and Immunology
Mihaela Oprea, David Sebastian Patriche, Monica Străuţ, Felicia Antohe
Infective endocarditis (IE) is an infection of the heart endothelium and valves and is frequently a consequence of a sanguine flow turbulence and injury of endocardium. Recent studies revealed an increase of Staphylococcus aureus strains involved in IE, but no evident correlations between the genetic background of this bacterium and IE involvement of certain strains have been found yet. In this study we analyzed the virulence profile, including adhesins, exotoxins, superantigens and biofilm determinants, along with agr type detection, for S...
July 2014: Roumanian Archives of Microbiology and Immunology
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