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Journal of Diabetes and its Complications

Signe T Andersen, Kasper Grosen, Hatice Tankisi, Morten Charles, Niels T Andersen, Henning Andersen, Ioannis N Petropoulos, Rayaz A Malik, Troels S Jensen, Pall Karlsson
AIMS: In this cross-sectional study, we explored the utility of corneal confocal microscopy (CCM) measures for detecting diabetic polyneuropathy (DPN) and their association with clinical variables, in a cohort with type 2 diabetes. METHODS: CCM, nerve conduction studies, and assessment of symptoms and clinical deficits of DPN were undertaken in 144 participants with type 2 diabetes and 25 controls. DPN was defined according to the Toronto criteria for confirmed DPN...
October 1, 2018: Journal of Diabetes and its Complications
Rasmus Bo Jansen, Bo Jørgensen, Per E Holstein, Klaus Kirketerp Møller, Ole Lander Svendsen
AIMS: Charcot foot is a rare but disabling complication to diabetic neuropathy, and can cause permanent, limb-threatening deformities. The aim of this study was to investigate a population of patients a Charcot foot on a case-by-case basis, in order to assess the consequences of an acute Charcot foot and its complications. METHODS: The study was conducted a retrospective study of patients admitted to the Copenhagen Wound Healing Center between 1996 and 2015 with the diagnosis of Charcot foot (DM14...
September 29, 2018: Journal of Diabetes and its Complications
Laura E Britton, Diane C Berry, Jon M Hussey
AIMS: Diabetes is associated with significant pregnancy complications, which can be further exacerbated by comorbid hypertension. Racial/ethnic differentials in the burden of comorbid hypertension and diabetes among women of reproductive age have not been described. METHODS: Using Wave IV of the nationally representative National Longitudinal Study of Adolescent to Adult Health (Add Health), we analyzed survey and biological data from 6576 non-pregnant women who were aged 24-32 in 2007-2008...
September 26, 2018: Journal of Diabetes and its Complications
Jens Oellgaard, Peter Gæde, Frederik Persson, Peter Rossing, Hans-Henrik Parving, Oluf Pedersen
BACKGROUND: Analyses of the urinary proteome have been proposed as a novel approach for early assessment of increased risk of renal- or cardiovascular disease. Here we investigate the potentials of various classifiers derived from urinary proteomics for prediction of renal and cardiovascular comorbidities in patients with type 2-diabetes. METHODS: The study was a post hoc analysis of the randomized controlled Steno-2 trial comparing intensified multifactorial intervention to conventional treatment of type 2-diabetes and microalbuminuria...
September 24, 2018: Journal of Diabetes and its Complications
Juliano B Farinha, Thiago R Ramis, Alexandra F Vieira, Rodrigo C O Macedo, Josianne Rodrigues-Krause, Francesco P Boeno, Helena T Schroeder, Carlos Henrique Müller, Winston Boff, Maurício Krause, Paulo Ivo H De Bittencourt, Alvaro Reischak-Oliveira
AIMS: To investigate the effects of high-intensity interval training (HIIT) and/or strength training (ST) on inflammatory, oxidative stress (OS) and glycemic parameters in type 1 diabetes (T1DM) patients. METHODS: After a 4-week control period, volunteers were randomly assigned to 10-week HIIT, ST or ST + HIIT protocol, performed 3×/week. Blood biochemistry, anthropometric, strength and cardiopulmonary fitness variables were assessed. Outcomes were analyzed via generalized estimating equations (GEE), with Bonferroni post hoc analysis...
September 19, 2018: Journal of Diabetes and its Complications
Victor W Zhong, Michael P Bancks, Pamela J Schreiner, Cora E Lewis, Lyn M Steffen, James B Meigs, Lauren A Schrader, Melanie Schorr, Karen K Miller, Stephen Sidney, Mercedes R Carnethon
AIMS: To determine the association between 20-year trajectories in insulin resistance (IR) since young adulthood and appendicular lean mass (ALM) at middle-age in adults without diabetes. METHODS: A prospective cohort study was designed among young and middle-aged US men (n = 925) and women (n = 1193). Fasting serum glucose and insulin were measured five times in 1985-2005. IR was determined using the homeostasis model assessment (HOMA). ALM was measured in 2005 and ALM adjusted for BMI (ALM/BMI) was the outcome...
September 17, 2018: Journal of Diabetes and its Complications
Eugene Han, Mi-Kyung Kim, Yong-Ho Lee, Hye Soon Kim, Byung-Wan Lee
AIM: Although albuminuria and urinary N-acetyl-β-d-glucosaminidase (uNAG) are known as progression markers of diabetic kidney disease, there is limited information regarding the association between urinary nonalbumin proteinuria (NAP) and uNAG and the clinical relevance thereof in patients without albuminuria. METHODS: This cross-sectional study included samples from 244 consecutive patients with type 2 diabetes mellitus (T2D) without albuminuria. Proteinuria and albuminuria were defined according to protein-to-creatinine ratio (uPCR) and albumin-to-creatinine ratio (uACR), respectively...
September 15, 2018: Journal of Diabetes and its Complications
Kazunori Sakurai, Yuko Kawai, Masanori Yamazaki, Mitsuhisa Komatsu
AIMS: Continuous glucose monitoring (CGM) is not available for all patients with type 2 diabetes (T2D) at risk of nocturnal hypoglycemia (NH). This study was performed to predict the lowest nocturnal blood glucose (LNBG) levels. METHODS: An LNBG prediction formula was developed by multivariate analysis using the data including self-monitoring of blood glucose from a formula making (FM) group of 29 insulin-treated T2D patients with CGM. The validity of the formula was assessed by nonparametric regression analysis of actual and predicted values in a formula validation group consisting of 21 other insulin-treated patients...
September 13, 2018: Journal of Diabetes and its Complications
Qiang Zhang, Hui-Min Liu, Wan-Qiang Lv, Jing-Yang He, Xin Xia, Wei-Dong Zhang, Hong-Wen Deng, Chang-Qing Sun
Genome-wide association studies (GWASs) have been performed extensively in diverse populations to identify single nucleotide polymorphisms (SNPs) associated with complex diseases or traits. However, to date, the SNPs identified fail to explain a large proportion of the variance of the traits/diseases. GWASs on type 2 diabetes (T2D) and coronary artery disease (CARD) are generally performed as single-trait studies, rather than analyzing the related traits simultaneously. Despite the extensive evidence suggesting that these two phenotypes share both genetic and environmental risk factors, the shared overlapping genetic biological mechanisms between these traits remain largely unexplored...
September 9, 2018: Journal of Diabetes and its Complications
Yang Xiao, Xiaoyu Xiao, Aimin Xu, Xiaoyan Chen, Weili Tang, Zhiguang Zhou
OBJECTIVE: The aim of this study was to investigate the prospective association of circulating adipocyte fatty acid-binding protein (A-FABP) levels with the development of subclinical atherosclerosis in patients with type 2 diabetes in an 8-year prospective study. METHODS: A total of 170 patients with newly diagnosed type 2 diabetes were recruited in the study and 133 patients completed the follow-up of 8 years. Baseline plasma A-FABP levels were measured with enzyme-linked immunosorbent assays...
September 7, 2018: Journal of Diabetes and its Complications
K Zekarias, A Kumar, A Moheet, E Seaquist
AIMS: To determine if impaired awareness of hypoglycemia in patients with type 1 diabetes persists over time and to assess if continuous glucose monitoring use was associated with improved awareness of hypoglycemia in our population. METHODS: Thirty-six with type 1 diabetes and impaired awareness of hypoglycemia who participated in studies on impaired awareness of hypoglycemia between 2009 and 2015 were contacted to complete an online survey. The survey included the Cox/Clarke and Gold hypoglycemia questionnaires and questions about continuous glucose monitoring use...
September 1, 2018: Journal of Diabetes and its Complications
Maya Fayfman, Georgia Davis, Elizabeth W Duggan, Maria Urrutia, David Chachkhiani, Joanna Schindler, Francisco J Pasquel, Rodolfo J Galindo, Priyathama Vellanki, David Reyes-Umpierrez, Heqiong Wang, Guillermo E Umpierrez
AIM: We investigated if a dipeptidyl peptidase-4 inhibitor, sitagliptin, can prevent perioperative stress hyperglycemia in patients without prior history of diabetes mellitus undergoing general surgery. METHODS: This double-blind pilot trial randomized general surgery patients to receive sitagliptin (n = 44) or placebo (n = 36) once daily, starting one day prior to surgery and continued during the hospital stay. The primary outcome was occurrence of stress hyperglycemia, defined by blood glucose (BG) >140 mg/dL and >180 mg/dL after surgery...
September 1, 2018: Journal of Diabetes and its Complications
Pandora L Wander, Tomoshige Hayashi, Kyoko Kogawa Sato, Shinichiro Uehara, Yonezo Hikita, Donna L Leonetti, Steven E Kahn, Wilfred Y Fujimoto, Edward J Boyko
AIMS: Visceral adiposity measured by computed tomography (CT) as intra-abdominal fat area (IAFA) predicts metabolic diseases. Existing adiposity surrogates have not been systematically compared to a regression-based model derived in individuals of Japanese ancestry. We developed and validated a method to estimate IAFA in individuals of Japanese ancestry and compared it to existing adiposity surrogates. METHODS: We assessed age, BMI, waist circumference (WC), fasting lipids, glucose, smoking status, grip strength, mid-thigh circumference (MTC), humeral length, leg length, and IAFA by single-slice CT at the umbilicus for 622 Japanese Americans...
November 2018: Journal of Diabetes and its Complications
J A Campbell, C E Mendez, E Garacci, R J Walker, N Wagner, L E Egede
BACKGROUND: ACEs have a dose-response relationship with diabetes. The relationship between ACEs and pre-diabetes is not well known and may represent an effective area for prevention efforts. METHODS: Data from 1054 participants from two waves of the longitudinal MIDUS study were used. Multivariate general linear regression models assessed the relationship between ACEs and biomarker outcomes. Correlation tests and mediation models investigated the relationship between ACE and pre-diabetes...
November 2018: Journal of Diabetes and its Complications
Yanfeng Ren, Leili Gao, Xiaohui Guo, Xiaoxu Huo, Juming Lu, Jing Li, Linong Ji, Xilin Yang
AIMS: Serum uric acid (SUA) and bilirubin at high levels had both pro-oxidant and anti-oxidant properties. The present study aimed to examine additive interactions between SUA and total bilirubin (TBIL) for the risk of micro-vascular disease (MVD) in type 2 diabetes mellitus (T2DM). METHODS: A cross-sectional survey of 6713 inpatients with T2DM was conducted in 81 tertiary care hospitals in China. MVD was defined as having either prior diabetic retinopathy (DR) or diabetic nephropathy (DN)...
November 2018: Journal of Diabetes and its Complications
Ruban Dhaliwal, Nicole C Foster, Claire Boyle, Mona Al Mukaddam, Ruth S Weinstock, Michael R Rickels, Viral N Shah, Linda A DiMeglio
AIMS: To examine the prevalence/determinants of fracture in the T1D Exchange Clinic Registry. RESEARCH DESIGN/METHODS: Adults (≥18 years) with T1D duration ≥5 years, diagnosed before age 45 years completed a fracture questionnaire. Additional characteristics were collected from registry data. Only fractures reported as occurring after T1D diagnosis were included. Characteristics were compared between those with and without fractures. RESULTS: Respondents included 756 adults (mean age 39 ± 16 years, 28% ≥50 years, 63% female, 90% non-Hispanic White, diabetes duration 24 ± 14 years); 48% reported ≥1 fracture since diagnosis...
November 2018: Journal of Diabetes and its Complications
TeriSue Smith-Jackson, Mary V Brown, Matthew Flint, Merilee Larsen
AIMS: This study examined delayed type one diabetes (T1D) diagnosis, along with the associated severity markers, in the United States. Qualitative reflection was explored to add depth of understanding. METHODS: 975 parents of a minor child with T1D were recruited through snowball, social media requests to complete a 55-question online survey on the experience of diagnosis. RESULTS: 34% of children with T1D had a delayed diagnosis. When compared to those without a delayed diagnosis, these children were more likely to have an Emergency Room diagnosis (39...
November 2018: Journal of Diabetes and its Complications
Amy C Alman, Jennifer W Talton, R Paul Wadwa, Elaine M Urbina, Lawrence M Dolan, Richard F Hamman, Ralph B D'Agostino, Santica M Marcovina, Dana M Dabelea
AIMS: We examined the association between inflammation and progression of arterial stiffness in a population of youth with type 1 diabetes (T1D). METHODS: A total of 287 youth with T1D (median age 13 years) from SEARCH CVD, an ancillary study to the SEARCH for Diabetes in Youth, were included. Markers of inflammation (CRP, IL-6, fibrinogen, leptin, and adiponectin) and measures of pulse wave velocity (PWV) of the arm (PWV-R), trunk (PWV-T), and lower extremity (PWV-LE) were measured at baseline...
November 2018: Journal of Diabetes and its Complications
Xiang Fang, Brenda Dorcely, Xi-Ping Ding, Shi Yin, Ni-Huiping Son, Shi-Lian Hu, Ira J Goldberg
OBJECTIVE: Systemic inflammation contributes to cardiovascular disease in patients with type 2 diabetes, and elevated white blood cell (WBC) counts are an established risk factor. Our goal is to describe changes in WBCs and inflammatory markers after glycemic reductions in diabetes. RESEARCH DESIGN AND METHODS: This study enrolled 63 subjects with poorly controlled diabetes, defined as hemoglobin A1c (HbA1c) ≥8% [64 mmol/mol]. Circulating granulocytes and mononuclear cells were separated by histopaque double-density protocol...
November 2018: Journal of Diabetes and its Complications
Linda Sommese, Giuditta Benincasa, Michele Lanza, Antonio Sorriento, Concetta Schiano, Roberta Lucchese, Roberto Alfano, Giovanni Francesco Nicoletti, Claudio Napoli
BACKGROUND: Epigenetics modulated tissue-specific gene expression during the onset of type 1 and type 2 diabetes and their complications. METHODS: We searched the PubMed recent studies about the main epigenetic tags involved in type 1 and type 2 diabetes onset and their clinical complications. PubMed studies about the epigenetic tags involved in type 1 and 2 diabetes onset was searched. RESULTS: The epigenetic methylation maps of cord blood samples highlighted differences in the methylation status of CpG sites within the MHC genes between carriers of diabetes type 1 DR3-DQ2 and DR4-DQ8 risk haplotypes...
November 2018: Journal of Diabetes and its Complications
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