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Journal of Diabetes and its Complications

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https://www.readbyqxmd.com/read/28711195/comparison-of-mdrd-ckd-epi-and-cockcroft-gault-equation-in-relation-to-measured-glomerular-filtration-rate-among-a-large-cohort-with-diabetes
#1
Anke Schwandt, Michael Denkinger, Peter Fasching, Martin Pfeifer, Christian Wagner, Jörg Weiland, Andrej Zeyfang, Reinhard W Holl
AIMS: To analyze the performance of Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), Cockcroft-Gault (CG), and CG calculated with ideal bodyweight (CG-IBW) equations to estimate glomerular filtration rate (eGFR) based on serum creatinine in a large diabetic population. METHODS: 24,516 adults with type-1-diabetes or type-2-diabetes from the multicenter diabetes prospective follow-up registry DPV were analyzed...
July 5, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28720321/no-evidence-for-progressive-deterioration-in-stimulated-insulin-secretion-in-renal-transplant-recipients-after-12years-tacrolimus-exposure
#2
Mariëlle A C J Gelens, Johannes P van Hooff, Len Usvyat, Maarten H Christiaans
AIMS: Tacrolimus (Tac) inhibits insulin secretion in a Tac-trough blood level dependent way early post-transplant in renal transplant recipients (Rtx). It is unknown whether long-term exposure results into a progressive beta cells dysfunction. METHODS: Two independent cohorts of Tac-treated non-diabetic Rtx, previously participating in glucose metabolism studies using intravenous Glucose Tolerance Test (ivGTT) were included: Fifty-eight Rtx were tested by ivGTT cross-sectional between 0...
July 4, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28728915/continuous-glucose-monitoring-adds-information-beyond-hba1c-in-well-controlled-diabetes-patients-with-early-cardiovascular-autonomic-neuropathy
#3
Jesper Fleischer, Esben Laugesen, Simon Lebech Cichosz, Pernille Hoeyem, Thomas Fremming Dejgaard, Per Loegstrup Poulsen, Lise Tarnow, Troels Krarup Hansen
AIMS: Hyperglycemia as evaluated by HbA1c is a risk factor for the development of cardiovascular autonomic neuropathy (CAN). The aim of the present study was to investigate whether continuous glucose monitoring (CGM) may add information beyond HbA1c in patients with type 2 diabetes and CAN. METHODS: 81 patients with type 2 diabetes (43 men, mean age 58±11year, HbA1c 6.6±0.5%). Patients were tested for CAN using cardiovascular reflex tests (response to standing, deep breathing and Valsalva maneuver) and underwent CGM for three days...
June 30, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28720320/hydrogen-sulfide-improves-diabetic-wound-healing-in-ob-ob-mice-via-attenuating-inflammation
#4
Huichen Zhao, Shengxia Lu, Jiachao Chai, Yuchao Zhang, Xiaoli Ma, Jicui Chen, Qingbo Guan, Meiyan Wan, Yuantao Liu
BACKGROUND: The proposed mechanisms of impaired wound healing in diabetes involve sustained inflammation, excess oxidative stress and compromised agiogenesis. Hydrogen sulfide (H2S) has been reported to have multiple biological activities. We aim to investigate the role of H2S in impaired wound healing in ob/ob mice and explore the possible mechanisms involved. PROCEDURES: Full-thickness skin dorsal wounds were created on ob/ob mice and C57BL/6 mice. Cystathionine-γ-lyase (CSE) expression and H2S production were determined in granulation tissues of the wounds...
June 30, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28716357/clinical-and-metabolic-response-to-flaxseed-oil-omega-3-fatty-acids-supplementation-in-patients-with-diabetic-foot-ulcer-a-randomized-double-blind-placebo-controlled-trial
#5
Zahra Soleimani, Fatemeh Hashemdokht, Fereshteh Bahmani, Mohsen Taghizadeh, Mohammad Reza Memarzadeh, Zatollah Asemi
BACKGROUND: Data on the effects of flaxseed oil omega-3 fatty acids supplementation on wound healing and metabolic status in subjects with diabetic foot ulcer (DFU) are scarce. OBJECTIVE: This study was conducted to evaluate the effects of flaxseed oil omega-3 fatty acids supplementation on wound healing and metabolic status in subjects with DFU. METHODS: The current randomized, double-blind, placebo-controlled trial was conducted among 60 subjects (aged 40-85years old) with grade 3 DFU...
June 28, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28668376/clinical-characteristics-beta-cell-dysfunction-and-treatment-outcomes-in-patients-with-a-%C3%AE-ketosis-prone-diabetes-kpd-the-first-identified-cohort-amongst-asian-indians
#6
Riddhi Das Gupta, Roshna Ramachandran, Praveen Gangadhara, Shajith Anoop, Surjitkumar H Singh, Anil Satyaraddi, Samantha Sathyakumar, H S Asha, Nihal Thomas
OBJECTIVE: Ketosis-prone diabetes (KPD), an atypical form of diabetes, has emerged as a heterogeneous syndrome in multiple ethnic groups. The objectives of this study were to look into the clinical characteristics of adult Asian Indian patients with recently diagnosed, antibody negative diabetes presenting with unprovoked ketoacidosis (A-β+ KPD) and to determine the natural course of recovery of beta-cell functions on serial follow-up over one year. RESEARCH DESIGN AND METHODS: Newly diagnosed adult diabetes patients (n=11) with suspected KPD (A-β+) were prospectively studied over a period of 1-year with serial evaluations of clinical, biochemical and beta-cell secretion characteristics...
June 23, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28705609/hand-shoulder-and-back-stiffness-in-long-term-type-1-diabetes-cross-sectional-association-with-skin-collagen-advanced-glycation-end-products-the-dialong-study
#7
Kristine Bech Holte, Niels Gunnar Juel, Jens Ivar Brox, Kristian Folkvord Hanssen, Dag Sigurd Fosmark, David R Sell, Vincent M Monnier, Tore Julsrud Berg
AIMS: We aimed to: (i) estimate the prevalence of Dupuytren's disease, trigger finger, carpal tunnel syndrome and frozen shoulder; (ii) assess stiffness of the hand, shoulder and back; and (iii) explore the association of joint stiffness with both long-term HbA1c and collagen advanced glycation end-products (AGEs) in long-term type 1 diabetes mellitus (T1DM). METHODS: Patients with T1DM from 1970 or earlier attending a specialized diabetes center were included in this cross-sectional controlled study...
June 22, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28669463/three-year-efficacy-and-safety-of-exenatide-once-weekly-a-pooled-analysis-of-three-trials
#8
Michael E Trautmann, Luc Van Gaal, Jenny Han, Elise Hardy
AIMS: To evaluate the 3-year efficacy and safety of exenatide once weekly (QW) for type 2 diabetes (T2D) in a large clinical population. METHODS: This post hoc analysis of three DURATION studies examined pooled efficacy and adverse events with exenatide QW from the 2.5- to 3-year completer populations; insulin glargine (glargine) was a reference (DURATION-3). Patients randomized to exenatide QW during the controlled study periods continued controlled treatment (DURATION-3) or single-arm treatment (DURATION-1; DURATION-2) with exenatide QW for the study duration...
June 20, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28647511/the-futile-cycle-of-hospital-readmission-in-patients-with-diabetes
#9
EDITORIAL
Janya Swami, Mary Korytkowski
No abstract text is available yet for this article.
June 17, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28655490/cancer-risks-of-anti-hyperglycemic-drugs-for-type-2-diabetes-treatment-a-clinical-appraisal
#10
REVIEW
Jiten Vora, Kausik Ray, Mikhail Kosiborod, Neil R Poulter, Sanjay Rajagopalan, Lawrence A Leiter
AIM: A clinical appraisal of existing scientific literature sought to assess the need for long-term prospective epidemiological studies to investigate an increased cancer risk of anti-hyperglycemic medication in type 2 diabetes. METHOD: A focus statement was formulated as: "With a higher risk of cancers in patients with type 2 diabetes, all anti-hyperglycemic drugs should undergo long-term, prospective epidemiological studies for cancer risks." Field surveys were sent to practicing physicians and endocrinologists to identify the currently prevalent level of acceptance of this statement...
June 15, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28645682/re-subclinical-thyroid-dysfunction-and-mortality-in-type-2-diabetes
#11
LETTER
Imran Badshah, S A Paul Chubb, Wendy A Davis, Timothy M E Davis
No abstract text is available yet for this article.
June 15, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28648555/comparison-of-plasma-pigment-epithelium-derived-factor-pedf-retinol-binding-protein-4-rbp-4-chitinase-3-like-protein-1-ykl-40-and-brain-derived-neurotrophic-factor-bdnf-for-the-identification-of-insulin-resistance
#12
F J K Toloza, M C Pérez-Matos, M L Ricardo-Silgado, M C Morales-Álvarez, J O Mantilla-Rivas, J A Pinzón-Cortés, M Pérez-Mayorga, M L Arévalo-García, G Tolosa-González, C O Mendivil
AIMS: To evaluate and compare the association of four potential insulin resistance (IR) biomarkers (pigment-epithelium-derived factor [PEDF], retinol-binding-protein-4 [RBP-4], chitinase-3-like protein 1 [YKL-40] and brain-derived neurotrophic factor [BDNF]) with objective measures of IR. METHODS: We studied 81 subjects with different metabolic profiles. All participants underwent a 5-point OGTT with calculation of multiple IR indexes. A subgroup of 21 participants additionally underwent a hyperinsulinemic-euglycemic clamp...
June 9, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28673663/participation-in-a-national-lifestyle-change-program-is-associated-with-improved-diabetes-control-outcomes
#13
Sandra L Jackson, Lisa R Staimez, Sandra Safo, Qi Long, Mary K Rhee, Solveig A Cunningham, Darin E Olson, Anne M Tomolo, Usha Ramakrishnan, Venkat K M Narayan, Lawrence S Phillips
AIMS: Clinical trials show lifestyle change programs are beneficial, yet large-scale, successful translation of these programs is scarce. We investigated the association between participation in the largest U.S. lifestyle change program, MOVE!, and diabetes control outcomes. METHODS: This longitudinal, retrospective cohort study used Veterans Health Administration databases of patients with diabetes who participated in MOVE! between 2005 and 2012, or met eligibility criteria (BMI ≥25kg/m(2)) but did not participate...
June 6, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28610947/impaired-balance-is-related-to-the-progression-of-diabetic-complications-in-both-young-and-older-adults
#14
Daisuke Kukidome, Takeshi Nishikawa, Miki Sato, Yoshiko Nishi, Risa Shimamura, Junji Kawashima, Seiya Shimoda, Hiroshi Mizuta, Eiichi Araki
AIMS: To investigate the balance ability in younger and older adults with diabetes and evaluate the associations between balance ability and microvascular complications. METHODS: This cross-sectional observational study compared 162 participants and 177 controls with and without type 2 diabetes, respectively. Balance ability was assessed using two static (one-legged stance and postural sway area) and two dynamic (Timed Up and Go [TUG] and Functional Reach) tests...
June 4, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28647512/effect-of-dipeptidyl-peptidase-4-inhibitors-on-circulating-tumor-necrosis-factor-%C3%AE-concentrations-a-systematic-review-and-meta-analysis-of-controlled-trials
#15
REVIEW
Stephen L Atkin, Niki Katsiki, Maciej Banach, Dimitri P Mikhailidis, Matteo Pirro, Amirhossein Sahebkar
OBJECTIVE: Dipeptidyl peptidase-4 (DPP-4) inhibitors improve glycemic control in patients with type 2 diabetes mellitus. There are also reports of an effect of these drugs in reducing inflammation through inhibition of tumor necrosis factor-α (TNF-α) that is an important mediator for several inflammatory processes. The present systematic review and meta-analysis were performed to evaluate the effect of DPP-4 inhibitors on circulating TNF-α levels in T2DM patients. METHODS: A systematic review and a meta-analysis were undertaken on all controlled trials of DPP-4 inhibitors that included measurement of TNF-α...
June 3, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28684145/glp-1-receptor-agonist-liraglutide-ameliorates-hepatosteatosis-induced-by-anti-cd3-antibody-in-female-mice
#16
Arata Itoh, Junichiro Irie, Hirotsune Tagawa, Yukie Kusumoto, Mari Kato, Nana Kobayashi, Kumiko Tanaka, Rieko Kikuchi, Masataka Fujita, Yuya Nakajima, Yuehong Wu, Satoru Yamada, Toshihide Kawai, William M Ridgway, Hiroshi Itoh
AIMS: Hepatosteatosis is mainly induced by obesity and metabolic disorders, but various medications also induce hepatosteatosis. The administration of anti-CD3 antibody was shown to induce hepatosteatosis, but changes in lipid and glucose metabolism remain unclear. We investigated the mechanism of hepatosteatosis induced by anti-CD3 antibody and the effects of glucagon-like peptide-1 (GLP-1) receptor agonist that was recently shown to affect immune function in metabolic disorders. METHODS: Anti-CD3 antibody was administered to female BALB/c and C...
June 1, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28610946/editorial-the-continuum-of-dysglycemia-predicting-progression-from-prediabetes-to-type-2-diabetes
#17
Sam Dagogo-Jack
No abstract text is available yet for this article.
May 27, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28610945/atherosclerosis-associated-with-dynamic-inflammation-changes-after-multifactorial-intervention-in-short-duration-type-2-diabetes-a-randomized-controlled-10-year-follow-up-trial
#18
Chunhong Shi, Lili Men, Cuiping Yu, Junjie Yao, Ran Bai, Yu Yang, Lipeng Sun, Guohua Sun, Guirong Song, Yuhong Zhang, Qian Xing, Jianling Du
PURPOSE: To analyze the impact of dynamic changes in inflammation on atherosclerosis in short-duration type 2 diabetes after multifactorial intervention. METHODS: In this randomized controlled study, a total of 150 type 2 diabetes patients who had a mean age of 49.8±7.3years, 51% male, with disease duration <1year and without evidence of atherosclerosis were randomized into an intensive intervention group (IG), in which patients received multiple risk factors intervention by the special project team and tried to reach the pre-determined intervention goals, and a conventional group (CG), in which patients received standard diabetes care by the clinic doctor...
May 25, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28587789/once-weekly-glucagon-like-peptide-1-receptor-agonist-albiglutide-vs-prandial-insulin-added-to-basal-insulin-in-patients-with-type-2-diabetes-mellitus-results-over-52-weeks
#19
Lawrence A Leiter, Jorge Luiz Gross, Francis Chow, Diane Miller, Susan Johnson, Bo Ahrén
We have previously reported that once-weekly albiglutide was noninferior to thrice-daily lispro for glycemic lowering, with decreased weight and risk of hypoglycemia, in patients inadequately controlled on basal insulin over 26 weeks. Findings after 52 weeks reveal similar responses to albiglutide as an add-on to insulin glargine.
May 25, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28579312/validation-of-a-quick-screening-instrument-for-measuring-fear-of-hypoglycaemia-in-persons-with-diabetes
#20
LETTER
C B Schmidt, B J Potter van Loon, E Kiliç, F J Snoek, A Honig
No abstract text is available yet for this article.
May 25, 2017: Journal of Diabetes and its Complications
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