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Journal of Diabetes and its Complications

Gulay Imadoglu Yetkin, Aysegul Atak Yucel, İshak Özel Tekin, Mustafa Yılmaz, Hakan Atalay, Ertan Yetkin
BACKGROUND: It has been shown that functional status of dendritic cells (DCs) in diabetic patients with unstable angina pectoris (UAP) are more mature and activated than diabetic patients without coronary artery disease (CAD) and none diabetic patients with UAP. Accordingly we aimed to assess the activation of DCs in patients with CAD with/and without Diabetes Mellitus (DM) and compare to those in subjects with normal coronary arteries (NCA). MATERIALS AND METHODS: Twenty three patients with severe CAD who were scheduled to coronary artery by-pass grafting surgery and 6 patients with angiographycally NCAs were included in the study...
November 23, 2018: Journal of Diabetes and its Complications
Aya Aly A El-Shazly, Alaliaa M Sallam, Mohamed H El-Hefnawy, Hala O El-Mesallamy
AIMS: Diabetic nephropathy (DN) that progress to end stage renal failure is a serious health problem. Autophagy is involved in DN pathogenesis. Finding renal prognostic biomarkers can help in the future renal status prevision. Therefore, the aim of current study was to evaluate and correlate circulating levels of autophagy regulator protein Unc-51-like kinase 1 (ULK-1) with the widely expressed receptor in mammalian kidney; epidermal growth factor receptor (EGFR); and the key functional podocyte protein podocin (PDCN)...
November 22, 2018: Journal of Diabetes and its Complications
LáShauntá M Glover, Alain G Bertoni, Sherita H Golden, Peter Baltrus, Yuan-I Min, Mercedes R Carnethon, Herman Taylor, Mario Sims
AIM: To examine the association of psychosocial resources with prevalent type 2 diabetes (T2D) in 5104 African American men and women. METHODS: Using data from the Jackson Heart Study (JHS), we evaluated the cross-sectional associations of four psychosocial resources (social support, optimism, religiosity, and social networks) with T2D [fasting glucose ≥126 mg/dL, or HbA1c ≥ 6.5%, or use of diabetic medication]. Multivariable Poisson regression estimated prevalence ratios (PR, 95% confidence interval-CI) of T2D by each psychosocial measure, adjusting for demographics, SES, waist circumference, health behaviors, and depressive symptoms...
November 22, 2018: Journal of Diabetes and its Complications
Zhuangli Zhu, Xiongfeng Chen, Yiqing Xiao, Junping Wen, Jinyan Chen, Kun Wang, Gang Chen
Gestational diabetes mellitus (GDM), which has an increasing global prevalence, contributes to the susceptibility to metabolic dysregulation and obesity in the offspring via epigenetic modifications. However, the underlying mechanism remains largely obscure. The current study established a GDM mice model to investigate the alternations in the metabolic phenotypes and genomic DNA methylation in the pancreas of the offspring. We found that in the GDM offspring, intrauterine hyperglycemia induced dyslipidemia, insulin resistance, and glucose intolerance...
November 9, 2018: Journal of Diabetes and its Complications
Lydia A Bazzano, Du Tingting
No abstract text is available yet for this article.
November 9, 2018: Journal of Diabetes and its Complications
Ishwarlal Jialal, Ajay Chaudhuri
ASCVD is the leading cause of mortality in T2DM. Inflammation appears to be pivotal in the genesis of ASCVD. As T2DM is also a pro-inflammatory state, our aim was to determine the benefit of anti-inflammatory strategies on ASCVD in T2DM. PubMed searches were conducted using the keywords of T2DM, ASCVD, Inflammation and clinical trials. Our data review suggests that the Mediterranean diet, GLP1 receptor agonists and a monoclonal antibody against IL-1 reduces ASCVD events in T2DM. The former 2 therapies appear to be safe...
November 8, 2018: Journal of Diabetes and its Complications
I Stafeev, N Podkuychenko, S Michurina, I Sklyanik, A Panevina, E Shestakova, K Yah'yaev, V Fedenko, E Ratner, A Vorotnikov, M Menshikov, Y Yashkov, Ye Parfyonova, M Shestakova
BACKGROUND: Obesity and type 2 diabetes mellitus (T2DM) are among the most important morbidity factors. In this study we tested the hypothesis that low proliferative potential of adipose derived stromal cells (ADSC) associates with reduced formation of new fat depots, excess accumulation of fat in the functional adipocytes and their hypertrophy, resulting in fat inflammation and insulin resistance. METHODS: We screened two groups of obese patients with or without T2DM, matched for BMI, age, and duration of obesity to test the hypothesis that hypertrophy and decreased renewal of adipocytes may underlie transition from obesity to T2DM...
November 4, 2018: Journal of Diabetes and its Complications
Nathan A Johnson, Alex L Barwick, Angela Searle, Martin J Spink, Stephen M Twigg, Vivienne H Chuter
AIMS: To describe the physical activity levels of an Australian community-based adult population with diabetes, and investigate the interaction between diabetes complications and physical activity. METHODS: Anthropometric, demographic, biochemical and self-reported physical activity measures (IPAQ) were performed. Associations and multiple regression analyses were undertaken between physical activity, known risk factors for diabetes complications, and history of cardiovascular disease (CVD), neuropathy and foot ulceration obtained from medical records...
November 4, 2018: Journal of Diabetes and its Complications
Kendra A Young, Amita Maturu, Carlos Lorenzo, Carl D Langefeld, Lynne E Wagenknecht, Yii-Der I Chen, Kent D Taylor, Jerome I Rotter, Jill M Norris, Neda Rasouli
OBJECTIVE: The TG/HDL-C ratio is used as a marker of insulin resistance (IR) in Caucasians; however, there is limited data in other ethnic groups. We hypothesized that the TG/HDL-C ratio is associated with IR in Hispanics and African Americans (AA). RESEARCH DESIGN AND METHODS: Data from the Insulin Resistance Atherosclerosis Family Study was examined for associations between TG/HDL-C ratio and IR, β-cell function and incident diabetes in non-diabetic Hispanics (n = 872, 63% female) and AA (n = 371, 61% female)...
November 3, 2018: Journal of Diabetes and its Complications
Daniel de Luis, Olatz Izaola, David Primo, R Aller
BACKGROUND & AIMS: A common G-to-A transition located 75 base pairs upstream (rs670) from transcription start site of the APOA1 gene has been related with some metabolic parameters. Our aim was to analyze the effects of rs670 APOA1 gene polymorphism on lipid profile and metabolic changes after two different hypocaloric diets. METHODS: 282 obese subjects were randomly allocated during 12 weeks (Diet HF - high fat diet vs. Diet LF - low fat diet). Anthropometric and biochemical status were evaluated...
November 3, 2018: Journal of Diabetes and its Complications
Chun-Lin Liu, Ming-Yen Lin, Shang-Jyh Hwang, Ching-Kuan Liu, Huei-Lan Lee, Ming-Tsang Wu
AIM: This study investigated the effect of severe hyperglycemia episodes on survival and associated factors related to risk of mortality in type 2 diabetes mellitus (DM) patients with dementia. METHODS: We enrolled all type 2 DM patients newly diagnosed as having dementia in Taiwan from 1998 to 2005. These patients were categorized into those who had hyperglycemia episodes and those who did not based on whether or not they had been hospitalized for hyperglycemia after dementia diagnosis...
October 25, 2018: Journal of Diabetes and its Complications
Ali Moheb-Alian, Flora Forouzesh, Amir Sadeghi, Kamran Rostami, Elham Aghamohammadi, Mohammad Rostami-Nejad, Mostafa Rezaei-Tavirani, Mohammad Reza Zali
BACKGROUND: Based on lack of data on the distribution of the related alleles in the T1D population in Iranian population, we assessed the frequency of HLA DQ2 and DQ8 haplotypes in patients with T1D with/without CD compared to healthy population. MATERIALS AND METHODS: 70 patients with T1D without celiac disease, 60 T1D cases with CD were compared to 150 healthy individuals during 2016. Ten mililiter Gheparinized blood samples were collected, genomic DNA was extracted and alleles were genotyped by Real-time PCR using SYBR Green as a low-resolution method...
October 25, 2018: Journal of Diabetes and its Complications
Cristina Bianchi, Michele Aragona, Cosimo Rodia, Walter Baronti, Giovanni de Gennaro, Alessandra Bertolotto, Stefano Del Prato
Freestyle Libre (FSL) system is a new method to detect glucose enabling a new paradigm in glucose monitoring and self-management. The sensor, reading the interstitial fluid glucose concentration, provides a numerical data of glucose level and a trend arrow that add context to static measurement of glucose level. Therefore, patients could easily follow the progression of their glucose levels over the time, allowing early detection and timely treatment of deviations from targeted glucose level range, thus preventing extreme fluctuations...
October 24, 2018: Journal of Diabetes and its Complications
Mohammad Z I Chowdhury, Fahmida Yeasmin, Doreen M Rabi, Paul E Ronksley, Tanvir C Turin
BACKGROUND: Diabetes is associated with an increased risk for cardiovascular diseases (CVD). Risk prediction models are tools widely used to identify individuals at particularly high-risk of adverse events. Many CVD risk prediction models have been developed but their accuracy and consistency vary. OBJECTIVE: This study reviews the literature on available CVD risk prediction models specifically developed or validated in patients with diabetes and performs a meta-analysis of C-statistics to assess and compare their predictive performance...
October 23, 2018: Journal of Diabetes and its Complications
Chi-Wei Chang, Kuo-Meng Liao, Yi-Ting Chang, Sheng-Hung Wang, Ying-Chun Chen, Gin-Chung Wang
Radial pulse spectrum has been shown to correlate with coronary stenosis in patients with type 2 diabetes mellitus (T2DM). In academia, it has not been demonstrated that the radial artery pulse spectrum is an independent risk factor for major adverse cardiovascular events (MACE), including myocardial infarction, stroke, and all-cause mortality. The primary objective of this study is to assess the risk of MACE, in patients with T2DM and to determine if an increase in MACE would be associated with a first harmonic (C1) increase in the radial artery pulse...
October 18, 2018: Journal of Diabetes and its Complications
Chun-Kai Huang, Vijay Shivaswamy, Pariwat Thaisetthawatkul, Lynn Mack, Nicholas Stergiou, Ka-Chun Siu
This study investigates spatiotemporal gait adjustments that occur while stepping over virtual obstacles during treadmill walking in people with/without diabetic peripheral neuropathy (DPN). Eleven adults with Type 2 diabetes mellitus, ten DPN, and 11 age-matched healthy adults (HTY) participated in this study. They stepped over forthcoming virtual obstacles during treadmill walking. Outcomes such as success rate, spatiotemporal gait characteristics during obstacle crossing, and correlations between these variables were evaluated...
October 17, 2018: Journal of Diabetes and its Complications
Su Fen Ang, Clara S H Tan, Ling Wang, Rajkumar Dorajoo, Jessie C W Fong, Winston Y C Kon, Joyce X Lian, Keven Ang, Jamaliah Bte Rahim, Babitha Jeevith, Simon B M Lee, Wern Ee Tang, Tavintharan Subramanium, Chee Fang Sum, Jian Jun Liu, Su Chi Lim
AIMS: Young-onset T2D (YT2D) is associated with a more fulminant course and greater propensity for diabetic complications. The association of PAX4 R192H (rs2233580) variation with YT2D was inconsistent partly because of its Asian-specificity and under-representation of Asians in international consortiums. Interestingly, in our preliminary YT2D (mean = 25 years old) cohort, the prevalence of PAX4 R192H variant was remarkably higher (21.4%) than the general population. Therefore, we sought to determine whether PAX4 R192H is associated with younger onset of T2D in our East Asian (Chinese) population...
October 13, 2018: Journal of Diabetes and its Complications
Mohan Natarajan, Samy L Habib, Robert L Reddick, Caroline R Delma, Krishnan Manickam, Thomas J Prihoda, Sherry L Werner, Sumathy Mohan
Previous studies demonstrated that global deficiency of eNOS in diabetic mice exacerbated renal lesions and that overexpression of eNOS may protect against tissue injury. Our study revealed for the first time overexpression of eNOS leads to disease progression rather than protection. Transgenic mice selectively expressing eNOS in endothelial cells (eNOSTg) were cross bred with Ins2Akita type-1 (AK) diabetic mice to generate eNOS overexpressing eNOSTg/AK mice. Wild type, eNOSTg, AK and eNOSTg/AK mice were assessed for kidney function and blood glucose levels...
October 13, 2018: Journal of Diabetes and its Complications
Petr Heneberg, Daniela Šimčíková, Marie Čecháková, Blanka Rypáčková, Petr Kučera, Michal Anděl
BACKGROUND: Testing for autoantibodies against the zinc transporter ZnT8 (ZnTA) is becoming routine in pediatric diabetes. However, available data are inconclusive when focusing on adult-onset diabetes, including autoimmune diabetes, which does not require insulin at diagnosis (LADA). BASIC PROCEDURES: We examined the ZnTA prevalence and titers and matched them with the clinical phenotype and PTPN22 genotypes of Czech LADA patients who were positive for GADA and/or IA2A and had a fasting C-peptide level >200 pmol/L at diagnosis as well as HNF4A-, GCK- or HNF1A-MODY patients and healthy controls...
October 13, 2018: Journal of Diabetes and its Complications
Bixia Gao, Shouling Wu, Jinwei Wang, Chao Yang, Shuohua Chen, Jinhong Hou, Junjuan Li, Yaozheng Yang, Kevin He, Minghui Zhao, Min Chen, Luxia Zhang
BACKGROUND: Information regarding the clinical phenotypes of diabetic kidney disease (DKD) might guide better practice for clinicians. We aim to compare the clinical features and long-term outcomes of proteinuric and non-proteinuric phenotypes of DKD, based on a prospective cohort of Chinese population. METHODS: Altogether 8811 Chinese participants with diabetes were included. Kidney function decline was defined as estimated glomerular filtration rate <60 mL/min·1...
October 12, 2018: Journal of Diabetes and its Complications
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