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Journal of Diabetes and its Complications

A Misra, Mario J Soares, Viswanathan Mohan, Shajith Anoop, Vishnu Abhishek, Ruchi Vaidya, Rajendra Pradeepa
The prevalence of overweight and obesity is escalating in South Asian countries. South Asians display higher total and abdominal obesity at a lower BMI when compared to Whites. Consequently, metabolic dysfunction leading to metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) will account for a majority of the health burden of these countries. In this review, we discuss those factors that contribute to MetS and T2DM in South Asians when compared to whites, focusing on adiposity. Abdominal obesity is the single-most important risk factor for MetS and its predisposition to T2DM...
August 4, 2018: Journal of Diabetes and its Complications
Xiaoqian Jia, Nan Li, Suhong Gao, Rongwei Ye, Jiamei Wang, Xiaohong Liu, Zhiwen Li
AIMS: To investigate the association between self-reported preconception body mass index (BMI) and the risk of abnormal glucose tolerance (AGT). METHODS: Data were obtained from a prospective cohort study conducted in China. We recruited 5305 qualified women who registered during 22-24 gestational weeks. Blood glucose was measured by trained professionals, and other health-related information was recorded prospectively. We used logistic regression to evaluate the relationship between preconception BMI with AGT and its subtypes, after controlling for potential confounders...
August 3, 2018: Journal of Diabetes and its Complications
Mamta Jaiswal, Lynn Ang, Kara Mizokami-Stout, Rodica Pop-Busui
AIM: To assess the relationship between glucose variability (GV) and non-dipping of blood pressure (BP) as a marker of cardiovascular autonomic neuropathy (CAN) among patients with type 1 diabetes (T1D). METHODS: Forty-one subjects with T1D (age 34 ± 13 years, duration 13 ± 6 years, HbA1c 8 ± 1.2%) without cardiovascular disease, dyslipidemia, or hypertension at baseline were enrolled in a 3-year observational cohort study. Subjects were phenotyped for CAN with heart rate variability, cardiovascular autonomic reflex tests, and 24-h BP profiles at baseline and during follow-up...
July 31, 2018: Journal of Diabetes and its Complications
Hadii M Mamudu, Pooja Subedi, Timir Paul, Ali E Alamin, Arsham Alamian, Liang Wang, David Stewart, Antwan Jones, Sam Harirforoosh, Gerald Blackwell, Matthew Budoff
AIM: To examine the risk factor of coronary artery calcium (CAC) in individuals with diabetes and those without diabetes in Central Appalachia. METHODS: Study population included 2479 asymptomatic participants who underwent CAC screening between August 2012 and November 2016. CAC score was classified into four categories [0 (no plaque), 1-99 (mild plaque), 100-399 (moderate plaque), and ≥400 (severe plaque)]. Multinomial logistic regression analyses were conducted to test the association between CAC and cardiovascular disease (CVD) risk factors among participants with diabetes, age and gender matched controls, and randomly selected controls...
July 19, 2018: Journal of Diabetes and its Complications
Anke Schwandt, Dominik Bergis, Michael Denkinger, Katja S C Gollisch, Dirk Sandig, Harald Stingl, Stefan Zimny, Reinhard W Holl
AIMS: To investigate risk factors for declining renal function among subjects with type-1-diabetes. METHODS: Observational study based on data from the diabetes registry DPV. 4424 type-1-diabetes subjects aged ≥18 years, age at onset <18 years were identified. Modification of Diet in Renal Disease (MDRD) equation was used to estimate glomerular filtration rate (eGFR). Annual rate of renal decline was estimated for each patient using hierarchic linear regression models...
July 19, 2018: Journal of Diabetes and its Complications
Wei Liu, Yanhua Wu, Feng Yu, Wenxue Hu, Xiaowu Fang, Wenke Hao
AIM: This study was purposed to figure out the contribution of Numb-induced Notch signaling to the development of diabetic nephropathy (DN). METHODS: Two hundred and twenty six DN patients were included, and human glomerular endothelial cells (RGEC) were cultured. MSCV-Numb-IRES-GFP, MSCV-Notch1-IRES-GFP and MSCV-Hes1-IRES-GFP were transfected to construct the recombinant retroviral vectors. RESULT: The over-expressed Numb and Notch1, as well as the under-expressed Hes-1 were correlated with the undesirable prognosis of DN patients (P < 0...
July 10, 2018: Journal of Diabetes and its Complications
V Aravindhan, V Kevinkumar, U Dhamodharan, V Viswanathan
BACKGROUND: Inflammation has long been identified as an essential component of both Type-2 diabetes and tuberculosis. Chemokines are low molecular weight proteins which play an important role in both inflammation (diabetes) and immunity (tuberculosis). METHODS: In this study, we measured the serum levels of IP-10, IL-8 and SDF-1 in subjects with Normal Glucose Tolerance (NGT-TB-  = 108; NGT-TB+  = 200), Pre-Diabetes (PDM-TB-  = 118; PDM-TB+  = 105), Newly Diagnosed Diabetes (NDM-TB-  = 105; NDM-TB+  = 63) and Known Diabetes (KDM-TB-  = 131; KDM-TB+  = 108), by ELISA...
July 8, 2018: Journal of Diabetes and its Complications
Alin O Stirban, Cosmina I Bondor, Bogdan Florea, Ioan A Veresiu, Norina A Gavan
OBJECTIVE: Advanced glycation end products (AGE) contribute to the development of diabetes complications. Their accumulation in skin can be non-invasively assessed by measurement of skin autofluorescence (SAF). Our study investigated whether SAF correlates with measures of diabetic peripheral neuropathy (DPN). METHODS: In a multi-center study (8 centers), 497 consecutive individuals with diabetes mellitus were investigated. Forearm SAF was measured using the AGE Reader (Groningen, The Netherlands)...
July 5, 2018: Journal of Diabetes and its Complications
Yan Shao, Xiaorong Li, John W Wood, Jian-Xing Ma
AIM: Diabetic retinopathy (DR) is the leading cause of vision loss in the working age population. Endothelial progenitor cells (EPC) play a vital role in vascular damage repair. This article will review recent progress regarding mitochondrial and EPC dysfunction associated with DR. RESULTS: EPCs represent a limited population of adult stem cells possessing vasculogenic potential postnatally; their number and function are changed in DR. Among all the function changes, mitochondrial dysfunction plays an important role in the dysregulation of EPCs, as mitochondria regulate energy balance, and cell fate determination...
July 4, 2018: Journal of Diabetes and its Complications
Zhongyan Tian, Yuqian Li, Linlin Li, Xiaotian Liu, Haiqing Zhang, Xia Zhang, Xinling Qian, Wen Zhou, Jingjing Jiang, Jingzhi Zhao, Lei Yin, Chongjian Wang
AIM: To assess the relationship between various obesity categories according to body mass index (BMI) and waist circumference (WC) and risk of type 2 diabetes mellitus (T2DM) among Chinese rural adults. METHODS: A total of 38,466 eligible participants were derived from The Henan Rural Cohort Study. Structured questionnaires and anthropometric and laboratory measurements were undertaken. Logistic regression was performed by gender. RESULTS: The age-standardized prevalence of T2DM in current study was 3...
June 27, 2018: Journal of Diabetes and its Complications
Stan R Ursem, Marc G Vervloet, Rahel M Büttler, Mariëtte T Ackermans, Mirjam M Oosterwerff, Elisabeth M V Eekhoff, Paul Lips, Mireille J Serlie, Susanne E la Fleur, Annemieke C Heijboer
AIMS: Different studies point to a link between glucose metabolism and Fibroblast Growth Factor 23 (FGF23), an osteocyte-derived phosphaturic hormone. We aimed to investigate in humans the effect of (I) a glucose load and (II) a hyperinsulinemic-euglycemic clamp on FGF23 concentrations and conversely (III) the effect of a diet-induced increase in FGF23 concentration on glucose and insulin concentrations. METHODS: Plasma cFGF23 concentrations were measured during: I...
June 27, 2018: Journal of Diabetes and its Complications
Stefan Amisten, Pontus Duner, Olof Asplund, Israa Mohammed Al-Amily, Leif Groop, Albert Salehi
AIM: The impact of BL11282, an imidazoline receptor (NISCH) agonist, on potentiation of glucose-stimulated insulin secretion (GSIS) from isolated human non-diabetic (ND) and type 2 diabetic (T2D) islets was investigated. METHODS: Analysis of mRNA was performed by RNA-sequencing and qPCR. Insulin and cAMP by RIA and ELISA respectively. RESULTS: RNA-sequencing data revealed that NISCH is highly expressed in fat tissues, islets, liver and muscles, with eight detectable splice variants of transcripts in islets...
June 26, 2018: Journal of Diabetes and its Complications
Harsahiba Kaur, Prakriti Joshee, Stephanie Franquemont, Amy Baumgartner, Jessica Thurston, Laura Pyle, Kristen J Nadeau, Viral N Shah
To understand the effect of type 1 diabetes (T1D) on bone mineral content (BMC) and bone density (BMD), we studied 125 T1D adolescents and 80 pubertal stage matched controls. T1D was associated with lower whole-body BMC and BMD compared to controls, even when adjusted for age, sex and sex hormones.
June 15, 2018: Journal of Diabetes and its Complications
William H Herman, Barbara H Braffett, Shihchen Kuo, Joyce M Lee, Michael Brandle, Alan M Jacobson, Lisa A Prosser, John M Lachin
OBJECTIVE: The Diabetes Control and Complications Trial (DCCT) demonstrated that intensive therapy for type 1 diabetes delayed the development of microvascular and neuropathic complications compared to conventional therapy. At the end of DCCT, all participants were trained in intensive therapy, care was transferred to community providers, and the difference in HbA1c between treatment groups narrowed and disappeared. Our objective was to describe the outcomes and the quality-of-life and costs associated with those outcomes in participants who maintained excellent vs...
June 12, 2018: Journal of Diabetes and its Complications
William H Herman, Barbara H Braffett, Shihchen Kuo, Joyce M Lee, Michael Brandle, Alan M Jacobson, Lisa A Prosser, John M Lachin
OBJECTIVE: To simulate the cost-effectiveness of historical and modern treatment scenarios that achieve excellent vs. poor glycemic control in type 1 diabetes (T1DM). RESEARCH DESIGN AND METHODS: We describe and compare the costs of intensive and conventional therapies for T1DM as performed during DCCT, and modern intensive and basic therapy scenarios using insulin analogs, pens, pumps, and continuous glucose monitoring (CGM) to achieve excellent or poor glycemic control...
June 12, 2018: Journal of Diabetes and its Complications
Lingling Zhang, Tianming Liu
AIM: To investigate the clinical significance of serum α-Klotho and β-Klotho levels in patients with type 2 diabetes mellitus (T2DM) and its associated complications. METHODS: Serum α-Klotho and β-Klotho levels were measured using an ELISA kit in 817 individuals, including 127 with T2DM, 106 with diabetic nephropathy, 99 with diabetic retinopathy, 108 with diabetic neuropathy, 102 with diabetic foot disease, 135 with T2DM and more than one complication and 140 healthy controls...
June 12, 2018: Journal of Diabetes and its Complications
Amena Keshawarz, Andrew R Piropato, Talia L Brown, Lindsey M Duca, Rachel M Sippl, R Paul Wadwa, Janet K Snell-Bergeon
AIMS: Compare physical activity (PA) levels in adults with and without type 1 diabetes and identify diabetes-specific barriers to PA. METHODS: Forty-four individuals with type 1 diabetes and 77 non-diabetic controls in the Coronary Artery Calcification in Type 1 Diabetes study wore an accelerometer for 2 weeks. Moderate-to-vigorous physical activity (MVPA) was compared by diabetes status using multiple linear regression. The Barriers to Physical Activity in Type 1 Diabetes questionnaire measured diabetes-specific barriers to PA, and the Clarke hypoglycemia awareness questionnaire measured hypoglycemia frequency...
June 2, 2018: Journal of Diabetes and its Complications
Timothy M Hughes, Kaycee M Sink, Jeff D Williamson, Christina E Hugenschmidt, Benjamin C Wagner, Christopher T Whitlow, Jianzhao Xu, S Carrie Smith, Lenore J Launer, Joshua I Barzilay, Faramarz Ismail-Beigi, R Nick Bryan, Fang-Chi Hsu, Donald W Bowden, Joseph A Maldjian, Jasmin Divers, Barry I Freedman
BACKGROUND: Relationships between cognitive function and brain structure remain poorly defined in African Americans with type 2 diabetes. METHODS: Cognitive testing and cerebral magnetic resonance imaging in African Americans from the Diabetes Heart Study Memory IN Diabetes (n = 480) and Action to Control Cardiovascular Risk in Diabetes MIND (n = 104) studies were examined for associations. Cerebral gray matter volume (GMV), white matter volume (WMV) and white matter lesion volume (WMLV) and cognitive performance (Mini-mental State Exam [MMSE and 3MSE], Digit Symbol Coding (DSC), Stroop test, and Rey Auditory Verbal Learning Test) were recorded...
May 29, 2018: Journal of Diabetes and its Complications
Saeko Osawa, Naoto Katakami, Ihoko Sato, Hiroyo Ninomiya, Kazuo Omori, Yuichi Yamamoto, Mitsuyoshi Takahara, Kazuyuki Miyashita, Fumie Sakamoto, Dan Kawamori, Takaaki Matsuoka, Iichiro Shimomura
AIMS: Tissue accumulatedadvanced glycation end products (AGEs) can be evaluated non-invasively by an autofluorescence reader as skin autofluorescence (skin AF)·The present study investigated whether skin AF is associated with diabetic micro- and macroangiopathies in Japanese patients with type 2 diabetes mellitus (T2DM). METHODS: Skin AF was measured in 193 enrolled Japanese patients with T2DM and 24 enrolled healthy non-diabetic subjects by using the AGE reader®...
September 2018: Journal of Diabetes and its Complications
Vybhav Venkatesh, Rakesh Kumar, Dinesh Kumar Varma, Prateek Bhatia, Jaivinder Yadav, Devi Dayal
BACKGROUND: There is limited data on platelet alterations in children with type 1 diabetes mellitus (T1DM). We planned to study the effect of glycemic control and duration of T1DM on platelet morphology in children with T1DM. METHODS: We conducted an observational study on 260 children; 130 with T1DM (cases) and 130 healthy controls, in a tertiary care pediatric hospital. Platelet indices including Platelet count (PLT), Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Platelet-Large cell ratio (P-LCR), Plateletcrit (PCT) were measured, and their means were compared between cases and controls and various subgroups among the cases...
September 2018: Journal of Diabetes and its Complications
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