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Journal of Diabetes and its Complications

Grazia Aleppo, Peter Calhoun, Nicole C Foster, David M Maahs, Viral N Shah, Kellee M Miller
OBJECTIVE: To better understand the prevalence and impact of gastroparesis in the T1D Exchange clinic registry database. METHODS: The analysis included 7107 adult participants with T1D across 45 sites (median age 46years. and median duration 24years). Linear and logistic regression models were used to assess the association of gastroparesis vs. no gastroparesis (obtained from medical record) with demographic characteristics, glycemic control and diabetes complications...
September 6, 2017: Journal of Diabetes and its Complications
Yi-Xiong Gao, Qingqing Man, Shanshan Jia, Yuqian Li, Lixiang Li, Jian Zhang
AIMS: This cross-sectional study aimed to investigate triglyceride level among Chinese elderly population with different diabetic progressions and related factors of triglyceride. METHODS: Study participants (≥65years) were recruited from a nationwide cross-sectional surveillance and were divided into four subgroups according to diabetic progression. Their information was obtained via questionnaire and physical examination. Their lipids in fasting serum samples were analyzed...
August 26, 2017: Journal of Diabetes and its Complications
Kanhaiya Singh, Prabhjot Goyal, Manju Singh, Sujit Deshmukh, Divyesh Upadhyay, Sri Kant, Neeraj K Agrawal, Sanjeev K Gupta, Kiran Singh
OBJECTIVE: Retinal angiogenesis is a hallmark of diabetic retinopathy. Matrix Metalloproteinases (MMPs) are involved in degradation of extracellular matrix (ECM). Functional SNP-1562C>T in the promoter of the MMP-9 gene results increase in transcriptional activity. The present work was designed to evaluate the contribution of functional SNP-1562C>T of MMP-9 gene to the risk of proliferative diabetic retinopathy (PDR) in type 2 diabetes mellitus (T2DM) patients in north Indian Population...
August 26, 2017: Journal of Diabetes and its Complications
P Z Benitez-Aguirre, A S Januszewski, Y H Cho, M E Craig, A J Jenkins, K C Donaghue
AIM: To examine the trajectory of small artery elasticity (SAE) and pulse pressure (PP) in people with Type 1 diabetes and non-diabetic controls across the lifespan, and explore associations with microvascular complications (CX+). METHODS: This cross-sectional study included 477 Type 1 diabetes patients (188 with CX+, 289 without CX-) and 515 controls. Relationships between SAE and PP and age were evaluated using segmented linear regression. Logistic regression was used to assess the associations between microvascular complications (retinopathy and/or nephropathy) and SAE and PP...
August 18, 2017: Journal of Diabetes and its Complications
Ping Yin, Ping Shao, Huikun Liu, Weiqin Li, Leishen Wang, Jing Wang, Shuang Zhang, Junhong Leng, Nan Li, Huiguang Tian, Xilin Yang, Zhijie Yu, Gang Hu
AIMS: To examine the association of connecting peptide (C-peptide) and the risks of postpartum diabetes and pre-diabetes among women with prior gestational diabetes. METHODS: A cross-sectional study of 1263 women with prior gestational diabetes was carried out at 1-5years after delivery in Tianjin, China. Logistic regression was used to assess the associations of C-peptide and the risks of diabetes and pre-diabetes. RESULTS: The multivariable-adjusted odds ratios based on different levels of C-peptide (0-33%, 34-66%, 67-90%, and >90% as C-peptide cutpoints) were 1...
August 17, 2017: Journal of Diabetes and its Complications
Evgenia Gourgari, Vanita R Aroda, Erin E Wilhelm, Hamid Hassanzadeh, Ira Shoulson
AIMS: FDA-approved drug labels are an important source of information for clinicians who prescribe medications for treatment of diabetes. We reviewed drug labels to (1) understand the landscape of classes of medications approved for type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM), (2) explore the indications and safety information and (3) examine their cardiovascular safety. METHODS: We searched four public references and reviewed all FDA-approved labels for "indication and usage," "adverse effects," "warnings and precautions," and "cardiovascular outcomes" from October 1982 to July 2016...
August 12, 2017: Journal of Diabetes and its Complications
Nathalie Auger, Tina Tang, Jessica Healy-Profitós, Gilles Paradis
AIMS: We assessed the long-term risk of cataract following a pregnancy complicated by gestational diabetes. METHODS: We carried out a longitudinal cohort study of 1,108,541 women who delivered infants between 1989-2013 in Quebec, Canada, with follow-up extending up to 25years later. The cohort included 71,862 women with gestational diabetes and 5247 with cataracts. We used Cox regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association of gestational diabetes with subsequent risk of cataract, adjusted for age, parity, socioeconomic status, time period, comorbidity, and type 2 diabetes...
August 9, 2017: Journal of Diabetes and its Complications
Andreas Schmitt, André Reimer, Dominic Ehrmann, Bernhard Kulzer, Thomas Haak, Norbert Hermanns
AIMS: Evidence from randomised trials analysing effects of depression treatment on glycaemic control in group comparisons is inconsistent. The aim of this study was to test if the reduction of depressive symptoms would explain improved glycaemic control irrespective of treatment groups. METHODS: The DIAMOS study tested effects of cognitive-behavioural therapy (CBT) versus usual care on depressive symptoms in a 12-month prospective trial; HbA1c was a secondary outcome...
August 9, 2017: Journal of Diabetes and its Complications
Anne Bijlsma-Rutte, Annemarie M J Braamse, Patricia van Oppen, Frank J Snoek, Paul Enzlin, Peter Leusink, Giel Nijpels, Petra J M Elders
AIMS: The identification and discussion of sexual care needs in people with type 2 diabetes mellitus (T2DM) in primary care is currently insufficient. The objective of this study was to determine the prevalence of sexual dissatisfaction, sexual problems and need for help by using a screening instrument among people with T2DM in primary care. METHODS: Data were collected in 45 general practices in the Netherlands from January 2015 to February 2016. The Brief Sexual Symptom Checklist (BSSC) was used to screen among 40-75 year old men and women...
August 4, 2017: Journal of Diabetes and its Complications
Charles C Chima, Jason L Salemi, Miranda Wang, Maria C Mejia de Grubb, Sandra J Gonzalez, Roger J Zoorob
AIMS: Information on the burden and risk factors for diabetes-depression comorbidity in the US is sparse. We used data from the largest all-payer, nationally-representative inpatient database in the US to estimate the prevalence, temporal trends, and risk factors for comorbid depression among adult diabetic inpatients. METHODS: We conducted a retrospective analysis using the 2002-2014 Nationwide Inpatient Sample databases. Depression and other comorbidities were identified using ICD-9-CM codes...
August 4, 2017: Journal of Diabetes and its Complications
Josef Finsterer, Sinda Zarrouk-Mahjoub
No abstract text is available yet for this article.
August 4, 2017: Journal of Diabetes and its Complications
Nirav Patel, Olivia Chen, Caroline Donahue, Binhuan Wang, Yixin Fang, Robert Donnino, Sundar Natarajan
BACKGROUND: Ischemic heart disease (IHD) is the most potent risk factor for heart failure (HF). Our study aims to evaluate the incremental impact of diabetes on the incidence of HF in individuals with IHD. METHODS: Data from the NHANES Epidemiologic Follow-Up Study (Baseline: 1971 to 1974) were linked to the facility and mortality files up to 1992. Our analyses were restricted to patients with IHD without prevalent HF at baseline. The cumulative incidence of HF in patients with diabetes and IHD versus those with IHD alone was assessed using failure curves...
August 3, 2017: Journal of Diabetes and its Complications
Ishwarlal Jialal, Roma Pahwa, Beverley Adams-Huet, David Siegel
No abstract text is available yet for this article.
August 3, 2017: Journal of Diabetes and its Complications
Franck Mauvais-Jarvis
No abstract text is available yet for this article.
August 3, 2017: Journal of Diabetes and its Complications
Gregory A Nichols, Kimberly G Brodovicz, Teresa M Kimes, Anouk Déruaz-Luyet, Dorothee B Bartels
OBJECTIVE: Epidemiological data on genitourinary infections (GUIs) comparing patients with and without type 2 diabetes (T2DM) is scant. We aimed to estimate the incidence of urinary tract infections (UTIs), genital infections (GIs), or any GUI in total and stratified by history of GUI and sex. RESEARCH DESIGN AND METHODS: We identified 39,295 patients in the Kaiser Permanente Northwest health plan with T2DM and an equal number of age and sex matched patients without diabetes...
August 3, 2017: Journal of Diabetes and its Complications
Chimaroke Edeoga, Ibiye Owei, Krishmita Siwakoti, Nkiru Umekwe, Fatoumatta Ceesay, Jim Wan, Sam Dagogo-Jack
AIMS: We assessed blood pressure (BP) and blood glucose (BG) values in healthy subjects, and examined baseline BP as a predictor of incident prediabetes during follow-up. METHODS: Participants in the Pathobiology of Prediabetes in a Biracial Cohort (POP-ABC) study underwent screening assessments (anthropometry, BP, OGTT) and were stratified into normal BP (NBP), prehypertension, or hypertension, and normal glucose regulation (NGR), prediabetes (IFG/IGT), or type 2 diabetes (T2D) status...
August 2, 2017: Journal of Diabetes and its Complications
Narasimmal Sai Prasanna, Anandakumar Amutha, Thyparambil Aravindakshan Pramodkumar, Ranjit Mohan Anjana, Ulagamathesan Venkatesan, Miranda Priya, Rajendra Pradeepa, Viswanathan Mohan
AIM: To analyse the OGTT glycemic parameters - fasting, 1h and 2h plasma glucose values singly and in various combinations; with respect to their prediction of future dysglycemia in subjects with normal glucose tolerance (NGT). METHODS: Electronic medical records of individuals who underwent an OGTT between 1991 and 2016 at a tertiary diabetes centre were analysed. NGT subjects who had at least one more follow up OGTT (n=1356) were selected for the study. Regarding their prediction of future dysglycemia, the glycemic parameters-Fasting plasma glucose (FPG), 1h plasma glucose (1HrPG) and 2h plasma glucose (2HrPG) were analysed separately and also in different combinations...
August 1, 2017: Journal of Diabetes and its Complications
Christine Emma Maria Krabbe, Sabine Schipf, Till Ittermann, Marcus Dörr, Matthias Nauck, Jean-François Chenot, Marcello Ricardo Paulista Markus, Henry Völzke
AIMS: Compare performances of diabetes risk scores and glycated hemoglobin (HbA1c) to estimate the risk of incident type 2 diabetes mellitus (T2DM) in Northeast Germany. METHODS: We studied 2916 subjects (20 to 81years) from the Study of Health in Pomerania (SHIP) in a 5-year follow-up period. Diabetes risk scores included the Cooperative Health Research in the Region of Augsburg (KORA) base model, the Danish diabetes risk score and the Data from the Epidemiological Study on the Insulin Resistance syndrome (D...
August 1, 2017: Journal of Diabetes and its Complications
Niharika Samala, Sarah A Tersey, Naga Chalasani, Ryan M Anderson, Raghavendra G Mirmira
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of pathologies associated with fat accumulation in the liver. NAFLD is the most common cause of liver disease in the United States, affecting up to a third of the general population. It is commonly associated with features of metabolic syndrome, particularly insulin resistance. NAFLD shares the basic pathogenic mechanisms with obesity and insulin resistance, such as mitochondrial, oxidative and endoplasmic reticulum stress. Lipoxygenases catalyze the conversion of poly-unsaturated fatty acids in the plasma membrane-mainly arachidonic acid and linoleic acid-to produce oxidized pro-inflammatory lipid intermediates...
July 31, 2017: Journal of Diabetes and its Complications
Berhanu Alemayehu, Jinan Liu, Swapnil Rajpathak, Samuel S Engel
AIMS: The objective of this study was to evaluate diabetes-related healthcare resource use and associated costs in patients with type 2 diabetes (T2DM) treated with a sulfonylurea (SU), with and without hypoglycemia. METHODS: In this retrospective cohort study, patients 18years or older receiving SU monotherapy or as add-on to metformin were identified from a US healthcare claims database (MarketScan®). Of 113,743 patients (56.8% male, average age 62.6years), 61...
July 28, 2017: Journal of Diabetes and its Complications
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