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Journal of Diabetes and its Complications

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https://www.readbyqxmd.com/read/29895439/three-year-renal-function-trajectory-and-its-association-with-adverse-renal-event-in-patients-with-type-2-diabetes
#1
Tsai-Chung Li, Tzu-Yun Yu, Chia-Ing Li, Chiu-Shong Liu, Wen-Yuan Lin, Chih-Hsueh Lin, Sing-Yu Yang, Jen-Huai Chiang, Cheng-Chieh Lin
AIMS: The study evaluated associations between 3-year eGFR trajectory patterns and adverse renal event in diabetic patients. METHODS: Adverse renal event was defined as sustained eGFR <60 or one ACR >300 mg/g creatinine. Cox proportional hazards models evaluated association between eGFR trajectory patterns and adverse renal event. RESULTS: We detected six clusters. Cluster 1 had a stable but relatively low baseline eGFR level (n = 823, 20...
May 31, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29907326/fgf21-protects-human-umbilical-vein-endothelial-cells-against-high-glucose-induced-apoptosis-via-pi3k-akt-fox3a-signaling-pathway
#2
Dongmin Guo, Lele Xiao, Huijun Hu, Mihua Liu, Lu Yang, Xiaolong Lin
AIMS: Diabetic macroangiopathy is the main cause of morbidity and mortality in patients with diabetes. Endothelial cell injury is a pathological precondition for diabetic macroangiopathy. Fibroblast growth factor 21 (FGF21) is a key metabolic regulator which has recently been suggested to protect cardiac myocytes and vascular cells against oxidative stress-induced injury in vitro and vivo. In this study, we aimed to investigate the protective capacity of FGF21 in human umbilical vein endothelial cells (HUVECs) against high glucose (HG)-induced apoptosis via phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt)/FoxO3a pathway...
May 25, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29895440/exploratory-lipidomics-in-patients-with-nascent-metabolic-syndrome
#3
Neeraj Ramakrishanan, Travis Denna, Sridevi Devaraj, Beverley Adams-Huet, Ishwarlal Jialal
BACKGROUND: Metabolic Syndrome (MetS) is a cardio-metabolic cluster that confers an increased risk of developing both diabetes and atherosclerotic cardiovascular disease (ASCVD). The mechanisms governing the increased ASCVD risk remains to be elucidated. Moreover, lipidomics poses as an exciting new tool that has potential to shed more light on the pathogenesis of MetS. OBJECTIVE: The aim of this study was to explore the lipidome in an unbiased fashion in patients with nascent MetS uncomplicated by diabetes and CVD...
May 25, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29887300/detection-of-asymptomatic-drug-induced-hypoglycemia-using-continuous-glucose-monitoring-in-older-people-systematic-review
#4
REVIEW
K Mattishent, Y K Loke
AIM: We conducted a systematic review of the use of continuous glucose monitoring (CGM) in older patients, in order to consolidate the growing evidence base in this area. METHODS: Our protocol was registered on PROSPERO (CRD42017068523). We searched SCI Web of Science, Ovid SP MEDLINE and EMBASE from January 2010 to June 2017 for observational studies and randomized controlled trial of CGM in older patients (mean age 65 or older) with diabetes. We excluded studies that involved only hospitalized patients...
May 18, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29871782/osteopontin-levels-in-plasma-muscles-and-bone-in-patient-with-non-healing-diabetic-foot-ulcers-a-new-player-in-wound-healing-process
#5
Z Feldbrin, E Omelchenko, A Lipkin, M Shargorodsky
BACKGROUND: The present study was designed to investigate the impact of osteopontin (OPN) in different tissue (e.g., plasma, muscles and bone) on amputation rate (in-hospital and during one year follow-up) for non-healing diabetic foot ulcers (DFUs). METHODS: This pilot study consisted of 30 diabetic patients, hospitalized due to non-healing DFUs. Patients were divided into two groups: Group 1 included 14 patients who underwent limb-preserved debridement procedure without amputation; Group 2 included 16 subjects who underwent amputation...
May 17, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29884473/age-at-menarche-and-age-at-natural-menopause-as-predictors-of-glycemic-control-in-type-2-diabetic-patients
#6
Chong Shen, Jinbo Wen, Xiaoqun Pan, Jian Su, Wencong Du, Enchun Pan, Qin Zhang, Ning Zhang, Hongyan Sheng, Chunlan Liu, Hui Wang, Ming Wu, Yu Qin
OBJECTIVE: To investigate the influence of age at menarche (AM) and age at natural menopause (ANM) on glycemic control in patients with type 2 diabetes mellitus (T2DM). METHODS: A cross-sectional study was undertaken in Jiangsu, China. Logistic regression was used to evaluate the association between AM/ANM and glycemic control. RESULTS: 1195 (14.3%) premenopausal and 7149 (85.7%) postmenopausal women were included in this study. With the increase of AM per 1 year, patients had a low risk of uncontrolled FPG (≥7 mmol/L) and uncontrolled HbA1c (≥7%), as well as poor glycemic control (FPG ≥7 mmol/L and HbA1c ≥7%) after adjusting for age and BMI (model I, P < 0...
May 16, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29861312/controlled-attenuation-parameter-in-nafld-identifies-risk-of-suboptimal-glycaemic-and-metabolic-control
#7
Preya Janubhai Patel, Fabrina Hossain, Leigh Ula Horsfall, Xuan Banh, Kelly Lee Hayward, Suzanne Williams, Tracey Johnson, Nigel Neil Brown, Nivene Saad, Patricia Casarolli Valery, Katharine Margaret Irvine, Andrew Donald Clouston, Katherine Anne Stuart, Anthony William Russell, Elizabeth Ellen Powell
AIMS: To examine the relationship between steatosis quantified by controlled attenuation parameter (CAP) values and glycaemic/metabolic control. METHODS: 230 patients, recruited from an Endocrine clinic or primary care underwent routine Hepatology assessment, with liver stiffness measurements and simultaneous CAP. Multivariable logistic regression was performed to identify potential predictors of Metabolic Syndrome (MetS), HbA1c ≥ 7%, use of insulin, hypertriglyceridaemia and CAP ≥ 300 dB/m...
May 12, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29843962/serological-inflammatory-factors-as-biomarkers-for-anatomic-response-in-diabetic-macular-edema-treated-with-anti-vegf
#8
Pedro Brito, Jorge Costa, Nuno Gomes, Sandra Costa, Jorge Correia-Pinto, Rufino Silva
PURPOSE: To study the relationship between systemic pro-inflammatory factors and macular structural response to intravitreal bevacizumab for diabetic macular edema (DME). METHODS: Prospective study including 30 cases with DME, treated with bevacizumab and a minimum follow-up of 6 months. All cases underwent baseline laboratory testing for cardiovascular risk (high sensitivity C-reactive protein (hsCRP), homocystein), dyslipidemia, renal dysfunction and glucose control...
May 11, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29903409/validation-of-data-from-electronic-data-warehouse-in-diabetic-ketoacidosis-caution-is-needed
#9
Jennifer VanderWeele, Teresa Pollack, Diana Johnson Oakes, Colleen Smyrniotis, Vidhya Illuri, Priyathama Vellanki, Kevin O'Leary, Jane Holl, Grazia Aleppo, Mark E Molitch, Amisha Wallia
AIMS: This study validated enterprise data warehouse (EDW) data for a cohort of hospitalized patients with a primary diagnosis of diabetic ketoacidosis (DKA). METHODS: 247 patients with 319 admissions for DKA (ICD-9 code 250.12, 250.13, or 250.xx with biochemical criteria for DKA) were admitted to Northwestern Memorial Hospital from 1/1/2010 to 9/1/2013. Validation was performed by electronic medical record (EMR) review of 10% of admissions (N = 32). Classification of diabetes type (Type 1 vs...
May 8, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29861313/patient-preferences-and-internet-use-for-diabetes-education-differs-by-age
#10
LETTER
Michael Quartuccio, Laura Minang, Rita R Kalyani
No abstract text is available yet for this article.
May 7, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29853261/fatty-acid-quality-and-quantity-of-diet-and-risk-of-type-2-diabetes-in-adults-tehran-lipid-and-glucose-study
#11
Parvin Mirmiran, Saeed Esfandyari, Sajjad Khalili Moghadam, Zahra Bahadoran, Fereidoun Azizi
AIM: Studies suggest that fatty acid intake may be an important determinant of type 2 diabetes mellitus (T2DM). This study aims to prospectively examine the association between fatty acid quantity and quality with risk of T2DM in adults. METHODS: In this community-based prospective sample, 2139 adults, free of T2DM, aged 20-70y-old were followed for a median of 5.8 y. Diet information was collected with the use of a validated questionnaire at baseline. Cox regression and 95% confidence intervals (CI), adjusted for age, diabetes risk score (DRS), and dietary intakes of energy, fiber and magnesium, were used to evaluate the association of fatty acid intakes with incident T2DM...
May 7, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29929836/sex-differences-in-neuropathic-pain-in-longstanding-diabetes-results-from-the-canadian-study-of-longevity-in-type-1-diabetes
#12
Nancy Cardinez, Leif E Lovblom, Johnny-Wei Bai, Evan Lewis, Alon Abraham, Daniel Scarr, Julie A Lovshin, Yuliya Lytvyn, Genevieve Boulet, Mohammed A Farooqi, Andrej Orszag, Alanna Weisman, Hillary A Keenan, Michael H Brent, Narinder Paul, Vera Bril, David Z Cherney, Bruce A Perkins
AIM: Neuropathy and neuropathic pain are common complications of type 1 diabetes (T1D). We aimed to determine if sex-specific differences in neuropathic pain are present in adults with longstanding T1D. METHODS: Canadians with ≥50 years of T1D (n = 361) completed health history questionnaires that included assessment of neuropathy (defined by Michigan Neuropathy Screening Instrument questionnaire components ≥3; NEUROPATHYMNSI-Q ) and neuropathic pain. Multivariable logistic regression was used to determine sex-differences in neuropathic pain controlling for neuropathy...
May 5, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29880432/renal-protection-by-sodium-glucose-cotransporter-2-inhibitors-and-its-underlying-mechanisms-in-diabetic-kidney-disease
#13
REVIEW
Akira Mima
AIM: Diabetic kidney disease (DKD) is the most frequent cause of mortality and morbidity, leading a global health burden. This review will focus on the potential therapeutic interventions using Sodium-glucose cotransporter-2 (SGLT2) inhibitors that could prevent the development and progression of DKD. RESULTS: SGLT2 inhibitors have been widely used as anti-diabetic drugs. Recent clinical studies have demonstrated that these drugs, which improve glycemic control and hypertension and decrease body weight, decrease the risk of renal function impairment and heart failure in patients with type 2 diabetes...
May 5, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29887299/motivation-and-attitudes-toward-changing-health-match-a-new-patient-reported-measure-to-inform-clinical-conversations
#14
Danielle M Hessler, L Fisher, W H Polonsky, V Bowyer, M Potter
OBJECTIVE: To identify and assess patient motivation to initiate or maintain behavior changes. METHODS: Attitudinal statements were developed from structured patient interviews and translated into 18 survey items. Items were analyzed with exploratory factor analysis (EFA). RESULTS: An EFA with 340 type 2 diabetes patients identified three areas of patient attitudes toward changing health behaviors: (1) willingness to make changes (3 items; α = 0...
April 27, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29857955/a-review-of-bone-metabolism-and-developments-in-medical-treatment-of-the-diabetic-charcot-foot
#15
REVIEW
Rasmus Bo Jansen, Ole Lander Svendsen
Charcot foot is a rare but severe, and possibly limb-threatening, complication to neuropathy and diabetes mellitus. The current treatment consists of long-term off-loading, and has a large negative impact on the patient's life. Much research has gone into understanding the condition and its biochemical mechanisms, however, the underlying pathogenesis of a Charcot foot is not yet fully understood. In the recent decades several key advances in our understanding of the Charcot foot have been made, both in regards to the changes in bone metabolism and structure an acute Charcot foot can cause, and to the molecular pathways involved in this...
April 27, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29907325/the-association-of-gestational-diabetes-mellitus-with-fetal-birth-weight
#16
Yi Yang, Zhaopin Wang, Minjia Mo, Xiamusiye Muyiduli, Shuojia Wang, Minchao Li, Shuying Jiang, Yimin Wu, Bule Shao, Yu Shen, Yunxian Yu
AIMS: Gestational diabetes mellitus (GDM) and different time-point glucose levels might have different effects on fetal birth weight. The aim of this study was to further evaluate the associations of GDM and different time-point blood glucose levels with fetal birth weight in a prospective cohort study. METHODS: This prospective cohort study was conducted in Zhoushan Maternal and Child Health Hospital, Zhejiang, from August 2011 to May 2015. 1232 pairs of singleton, full-term newborns and their mothers without other pregnant and perinatal complications were selected as participants...
April 25, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29751961/recurrent-hospitalizations-for-severe-hypoglycemia-and-hyperglycemia-among-u-s-adults-with-diabetes
#17
Rozalina G McCoy, Jeph Herrin, Kasia J Lipska, Nilay D Shah
AIMS: Examine 30-day readmissions for recurrent hypoglycemia and hyperglycemia in a national cohort of adults with diabetes. METHODS: Retrospective analysis of data from OptumLabs Data Warehouse for all adults with diabetes hospitalized January 1, 2009 to December 31, 2014 with a principal diagnosis of hypoglycemia or hyperglycemia. We examined the rates and risk factors of 30-day readmissions for hypoglycemia and hyperglycemia. RESULTS: After 6419 index hypoglycemia hospitalizations, 1...
April 24, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29857956/waist-to-hip-ratio-is-the-most-relevant-obesity-index-at-each-phase-of-insulin-secretion-among-obese-patients
#18
Meng-Meng Liu, Qing-Jing Liu, Jie Wen, Min Wang, Liang-Yan Wu, Min-Li Qu, Mei Li, Min-Xue Shen, Jing Wu
We aimed to explore the relationship between different obesity indices and insulin secretion at each phase among obese subjects and to find out the most relevant obesity index. Height, weight, waist circumstance, and hip circumstance were obtained among 419 obese subjects to calculate body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio, body adiposity index (BAI), conicity index, abdominal volume index and a body shape index (ABSI). Fasting plasma glucose and fasting insulin were detected to calculate HOMA-β...
April 22, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29753600/association-between-diabetes-mellitus-and-hearing-impairment-in-american-and-korean-populations
#19
Shinje Moon, Jung Hwan Park, Jae Myung Yu, Moon-Ki Choi, Hyung Joon Yoo
AIMS: The aim of this study was to evaluate ethnic- and sex-specific associations between DM and hearing impairment. METHODS: For this cross-sectional study using National Health and Nutrition Examination Survey in the U.S. and Korea, the total number of eligible participants included was 7081 in the U.S. and 15,704 in Korea. Hearing impairment was defined as a pure tone threshold level ≥ 25 dB. Multivariate logistic regression analysis was conducted, adjusting for age, sex, race/ethnicity, socioeconomic status, body mass index, noise exposure, smoking, hypertension, and dyslipidemia...
April 20, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29747995/the-effects-of-diabetes-therapy-on-bone-a-clinical-perspective
#20
REVIEW
Karim G Kheniser, Carmen M Polanco Santos, Sangeeta R Kashyap
The effects of diabetes and diabetes therapy on bone are less known among clinicians. Traditionally, the emphasis of diabetes therapy has been on reducing cardiovascular risk by facilitating reductions in weight, blood pressure, blood sugar, systemic inflammation, and lipid levels. Now, with ample research demonstrating that patients with diabetes are more susceptible to bone fractures relative to controls, there has been a greater or renewed interest in studying the effects of diabetes therapy on bone. Interestingly, the majority of antidiabetic agents positively affect bone, but a few have detrimental effects...
April 19, 2018: Journal of Diabetes and its Complications
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