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Journal of Diabetes and its Complications

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https://www.readbyqxmd.com/read/28433447/impaired-fasting-glucose-predicts-the-development-of-hypertension-over-6years-in-female-adults-results-from-the-rural-chinese-cohort-study
#1
Yang Zhao, Haohang Sun, Bingyuan Wang, Ming Zhang, Xinping Luo, Yongcheng Ren, Junmei Zhou, Chengyi Han, Chongjian Wang, Linlin Li, Lu Zhang, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Dongsheng Hu
AIMS: To investigate whether impaired fasting glucose (IFG) is an independent risk factor for incident hypertension in a rural Chinese population. METHODS: We selected 9583 eligible participants 18 to 75years old, who were without hypertension and diabetes at baseline (from 2007 to 2008) and were from a rural area in the middle of China. Concentration of fasting glucose at baseline was assessed in quartiles to predict hypertension risk by gender. Odds ratios (ORs) and 95% confidence intervals (CIs) for IFG (fasting glucose of 100 to 125mg/dl) associated with hypertension were estimated by logistic regression models...
April 11, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28433448/anemia-complicating-type-2-diabetes-prevalence-risk-factors-and-prognosis
#2
Richard Gauci, Michael Hunter, David G Bruce, Wendy A Davis, Timothy M E Davis
AIMS: To determine the prevalence, risk factors and prognosis of anemia in representative community-based patients with type 2 diabetes. METHODS: Data from the Fremantle Diabetes Study Phase II (FDS2; n=1551, mean age 65.7years, 51.9% males) and Busselton Diabetes Study (BDS; n=186, mean age 70.2years, 50.0% males) cohorts, and from 186 matched BDS participants without diabetes, were analyzed. The prevalence of anemia (hemoglobin ≤130g/L males, ≤120g/L females) was determined in each sample...
April 6, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28412033/antagonism-of-vasopressin-v2-receptor-improves-albuminuria-at-the-early-stage-of-diabetic-nephropathy-in-a-mouse-model-of-type-2-diabetes
#3
Ray El Boustany, Christopher Taveau, Catherine Chollet, Gilberto Velho, Lise Bankir, François Alhenc-Gelas, Ronan Roussel, Nadine Bouby
AIMS: Vasopressin is increased in diabetes and was shown to contribute to development of diabetic nephropathy through V2 receptor (V2R) activation in an experimental model of type 1 diabetes. The role of V2R in type 2 diabetes remains undocumented. This study addresses the issue in a mouse model of type 2 diabetes. METHODS: Male obese diabetic db/db mice were treated for 12weeks with a selective V2R antagonist (SR121463) and compared to non-treated db/db and non-diabetic db/m mice...
April 6, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28427838/stratification-strategy-for-evaluating-the-influence-of-diabetes-complication-severity-index-on-the-risk-of-hospitalization-a-record-linkage-data-in-western-australia
#4
Ninh Thi Ha, Mark Harris, Suzanne Robinson, David Preen, Rachael Moorin
OBJECTIVE: This study aimed to develop a risk stratification strategy for evaluating the relationship between complications of diabetes and the risk of diabetic-related hospitalization to accurately classify diabetes severity. METHODS: The study used administrative health records for 40,624 individuals with diabetes aged ≥18years in Western Australian. The adapted Diabetes Complication Severity Index (DCSI), socio-demographic and clinical characteristics were used in random effects negative binomial and threshold effect models to determine the optimal stratification strategy for diabetes severity based on the homogeneity of the risk of hospitalization in response to variation of the DCSI...
April 5, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28416121/silent-coronary-heart-disease-in-patients-with-type-2-diabetes-application-of-a-screening-approach-in-a-follow-up-study
#5
Saula Vigili de Kreutzenberg, Anna Solini, Edoardo Vitolo, Alessandra Boi, Simonetta Bacci, Sara Cocozza, Rossella Nappo, Angela Rivellese, Angelo Avogaro, Marco Giorgio Baroni
AIMS: The cost-effectiveness of screening for silent coronary heart disease (CHD) in type 2 diabetes (DM2) is still debated. METHODS: We applied a diagnostic algorithm for silent CHD detection, in a cohort of 102 asymptomatic DM2 subjects (57±7years), attending 5 Italian outpatient clinics, to verify its predictive value. The risk of silent CHD was calculated considering classical risk factors, and presence of microangiopathy/macroangiopathy. Patients were divided in 3 groups, i...
April 4, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28410925/circulating-osteocalcin-is-unrelated-to-glucose-homoeostasis-in-adults-with-type-1-diabetes
#6
Bu B Yeap, Wendy A Davis, Kirsten Peters, Emma J Hamilton, Valentina Rakic, Stephen A Paul Chubb, Timothy M E Davis
AIMS: To assess the relationship between total osteocalcin (tOC), undercarboxylated osteocalcin (ucOC) and a range of markers of glucose homeostasis in type 1 diabetes. METHODS: One hundred and eight community-based Caucasian adults (53 males, 55 females) without a history of osteoporosis and with a mean±SD age 39.1±15.1years and median [inter-quartile range] type 1 diabetes duration of 14.3 [6.6-20.4] years participated in a cross-sectional study of bone health...
April 4, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28410926/effect-of-high-density-lipoprotein-cholesterol-on-the-relationship-of-serum-iron-and-hemoglobin-with-kidney-function-in-diabetes
#7
Ashley N Williams, Baqiyyah N Conway
Findings of increased hemoglobin inside the HDL proteome among persons with diabetes who have haptoglobin 2-2 genotype suggest that iron-induced lipid peroxidation may be involved in diabetic kidney disease. We investigated the relationships of serum hemoglobin and iron with kidney function, and whether this varied by level of HDLc, in 5296 adults with and 49,161 without diabetes. Estimated eGFR was our marker of kidney function. Hemoglobin was positively associated with eGFR among those with diabetes and inversely among those without diabetes (interaction p-value <0...
March 29, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28392044/asymmetric-dimethylarginine-and-arginine-metabolites-in-women-with-and-without-a-history-of-gestational-diabetes
#8
Sumedha Arya, Chang Ye, Philip W Connelly, Anthony J Hanley, Mathew Sermer, Bernard Zinman, Ravi Retnakaran
AIMS: Dysregulation of arginine metabolism, as evidenced by increased circulating levels of asymmetric dimethylarginine (ADMA), has been proposed as an early event in the natural history of cardiovascular disease. Since the diagnosis of gestational diabetes mellitus (GDM) identifies a patient population at increased future risk of cardiovascular disease later in life, we sought to characterize arginine metabolism in women with and without a history of recent GDM. METHODS: In this prospective observational cohort study, 225 women (72 who had GDM; 153 who did not) underwent cardiometabolic characterization, including oral glucose tolerance test, at 1- and 3-years postpartum...
March 28, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28410927/younger-onset-versus-older-onset-type-2-diabetes-clinical-profile-and-complications
#9
Ranjit Unnikrishnan, Ranjit Mohan Anjana, Anandakumar Amutha, Harish Ranjani, Saravanan Jebarani, Mohammed K Ali, K M Venkat Narayan, Viswanathan Mohan
AIMS: To compare the clinical profile and complications between younger and older onset type 2 diabetes (T2DM) patients at a tertiary care diabetes center in south India. METHODS: We compared individuals with T2DM detected at age ≤25years (n=267) and at age≥50years (n=267), matched for gender and duration of diabetes. We reviewed electronic patient charts and extracted data on biochemical parameters (plasma glucose, serum lipids and glycated hemoglobin). We estimated prevalence of complications (retinopathy, nephropathy, neuropathy, and peripheral vascular disease)...
March 23, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28392043/the-impact-of-diabetes-on-mobility-balance-and-recovery-after-repositioning-maneuvers-in-individuals-with-benign-paroxysmal-positional-vertigo
#10
Linda J D'Silva, Susan L Whitney, Marcio Santos, Hongying Dai, Patricia M Kluding
AIM: The prevalence of benign paroxysmal positional vertigo (BPPV) is higher in people with type 2 diabetes (DM). The impact of DM on mobility, balance, and management of BPPV is unknown. This prospective study compared symptom severity, mobility and balance before and after the canalith repositioning maneuver (CRM) in people with posterior canal BPPV canalithiasis, with and without DM. METHODS: Fifty participants, BPPV (n=34) and BPPV+DM (n=16) were examined for symptom severity (dizziness handicap inventory, DHI), mobility (functional gait assessment, FGA), and postural sway (using an accelerometer in five conditions) before and after the CRM...
March 22, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28392042/relationship-of-shoulder-activity-and-skin-intrinsic-fluorescence-with-low-level-shoulder-pain-and-disability-in-people-with-type-2-diabetes
#11
Christopher J Sorensen, Mary K Hastings, Catherine E Lang, Janet B McGill, B Ruth Clark, Kathryn L Bohnert, Michael J Mueller
AIM: People with type 2 diabetes (T2DM) have a high incidence of musculoskeletal disorders thought to be influenced by high non-enzymatic advanced glycated end-products (AGEs). The goals of this study were to determine differences in shoulder activity level and AGEs in people with T2DM compared to matched controls, and to determine factors associated with shoulder pain and disability. METHODS: Eighty-one participants, T2DM (n=52) and controls (n=29), were examined for magnitude and duration of shoulder activity (measured using accelerometers), skin intrinsic florescence (SIF) as a surrogate measure of AGE level, and the Shoulder Pain and Disability Index (SPADI) as a self-report of shoulder pain and disability...
March 18, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28363729/independent-correlates-of-chronic-kidney-disease-awareness-among-adults-with-type-2-diabetes
#12
Ndidiamaka O Obadan, Rebekah J Walker, Leonard E Egede
BACKGROUND: Chronic Kidney Disease (CKD) is usually silent until advanced stages. Awareness of CKD is important to mitigate poorer outcomes. This study aims to understand the relationship(s) between CKD self-awareness and diagnosed CKD. METHODS: The study included 345 adults with type 2 diabetes from two primary care settings. Participants completed surveys assessing demographic information, self-care behaviors and co-morbidities. Biological data were taken from medical records...
March 18, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28347695/association-of-sarcopenia-with-both-latent-autoimmune-diabetes-in-adults-and-type-2-diabetes-a-cross-sectional-study
#13
Ryotaro Bouchi, Tatsuya Fukuda, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa
BACKGROUND: To investigate the association of both latent autoimmune diabetes in adults (LADA) and type 2 diabetes (T2DM) with muscle mass and function (sarcopenia). METHODS: Japanese patients with LADA (N=20), T2DM (N=208), and control subjects (N=41) were included in this cross-sectional study. The definition of LADA was based on age of onset (≥30), positive glutamic acid decarboxylase autoantibodies, and insulin requirement within the first 6months after diagnosis...
March 15, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28416120/diabetes-complications-severity-index-dcsi-update-and-icd-10-translation
#14
William P Glasheen, Andrew Renda, Yanting Dong
AIMS: The Diabetes Complications Severity Index (DCSI) converts diagnostic codes and laboratory results into a 14-level metric quantifying the long-term effects of diabetes on seven body systems. Adoption of the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) necessitates translation from ICD-9-CM and creates refinement opportunities. METHODS: ICD-9 codes for secondary and primary diabetes plus all five ICD-10 diabetes categories were incorporated into an updated tool...
March 14, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28363730/what-factors-influence-uptake-of-retinal-screening-among-young-adults-with-type-2-diabetes-a-qualitative-study-informed-by-the-theoretical-domains-framework
#15
Amelia J Lake, Jessica L Browne, Gwyneth Rees, Jane Speight
AIMS: Young adults with type 2 diabetes (T2D, 18-39years) face increased risk of vision loss from diabetic retinopathy (DR). Retinal screening is essential to detect DR, yet screening rates for this group are low and little is known about the underlying factors influencing this important behavior. Using the theoretical domains framework (TDF) to guide data collection and analysis, we explored screening barriers and facilitator, contrasting them with a comparator group of older adults with T2D (40+ years)...
March 14, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28343792/liberating-a1c-goals-in-older-adults-may-not-protect-against-the-risk-of-hypoglycemia
#16
Medha N Munshi, Christine Slyne, Alissa R Segal, Nora Saul, Courtney Lyons, Katie Weinger
AIMS: Hemoglobin A1C is universally used as a marker for glycemic control and to establish glycemic goals in patients with diabetes. In the older population, experts recommend liberating A1C goals to decrease the risk of hypoglycemia. However, it's not clear which A1C level is optimal for this purpose. This study's aim was to understand the relationship between A1C levels and risk of hypoglycemia. METHODS: In a prospective study, we performed continuous glucose monitoring (CGM) on older adults on insulin...
March 14, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28325698/factors-associated-with-antidiabetic-medication-non-adherence-in-patients-with-incident-comorbid-depression
#17
Carlotta Lunghi, Arsène Zongo, Jocelyne Moisan, Jean-Pierre Grégoire, Line Guénette
AIM: To identify factors associated with antidiabetic drug (AD) non-adherence among patients with type 2 diabetes and depression. STUDY DESIGN AND SETTINGS: We conducted a population-based retrospective cohort study among new AD users with a diagnosis of depression following AD initiation. We used public health insurance data from Quebec. The dependent variable was non-adherence (i.e., <90% of days covered by ≥1AD) in the year after a depression diagnosis. Different sociodemographic, clinical and medication-related variables were assessed as potential factors of non-adherence to AD treatment...
March 12, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28433449/diabetes-depressive-symptoms-and-functional-disability-in-african-americans-the-jackson-heart-study
#18
Rita Rastogi Kalyani, Nan Ji, Mercedes Carnethon, Alain G Bertoni, Elizabeth Selvin, Edward W Gregg, Mario Sims, Sherita Hill Golden
AIMS: To investigate the degree to which comorbid depression contributes to the relationship of diabetes with functional disability in African Americans (AAs), a population at high-risk for complications. METHODS: We examined 2989 African Americans (AAs) in the Jackson Heart Study who had diabetes and depressive symptoms (CES-D) assessed at baseline. Overall functional disability was defined as the inability to perform at least one task of daily living. Multivariable logistic regression models explored the association of diabetes and depressive symptoms with functional disability...
March 9, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28392041/arterial-stiffness-is-an-independent-predictor-for-albuminuria-progression-among-asians-with-type-2-diabetes-a-prospective-cohort-study
#19
Xiao Zhang, Serena Low, Chee Fang Sum, Subramaniam Tavintharan, Yeoh Lee Ying, Jianjun Liu, Na Li, Keven Anga, Simon Bm Lee, Wern Ee Tang, Su Chi Lim
AIM: Albuminuria progression has been associated with renal deterioration in type 2 diabetes (T2DM). Central arterial stiffness can aggravate systemic vasculopathy by propagating elevated systolic and pulse pressures forward, thereby accentuating global vascular injury. We aim to investigate whether central arterial stiffness is an independent predictor for albuminuria progression in a multi-ethnic T2DM Asian cohort in Singapore. METHODS: In a prospective cohort, 1012 T2DM patients were assessed at baseline and after a median follow-up of 3...
February 14, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28254346/persistent-inflammation-with-pedal-osteolysis-1year-after-charcot-neuropathic-osteoarthropathy
#20
David R Sinacore, Kathryn L Bohnert, Kirk E Smith, Mary K Hastings, Paul K Commean, David J Gutekunst, Jeffrey E Johnson, Fred W Prior
AIMS: To determine local and systemic markers of inflammation and bone mineral density (BMD) in the foot and central sites in participants with diabetes mellitus and peripheral neuropathy (DMPN) with and without acute Charcot neuropathic osteoarthropathy (CN). METHODS: Eighteen participants with DMPN and CN and 19 participants without CN had foot temperature assessments, serum markers of inflammation [C-reactive protein, (CRP) and erythrocyte sedimentation rate, (ESR)] and BMD of the foot, hip and lumbar spine at baseline and 1year follow-up...
February 14, 2017: Journal of Diabetes and its Complications
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