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Journal of Diabetes and its Complications

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https://www.readbyqxmd.com/read/27913013/nonalbumin-proteinuria-is-a-simple-and-practical-predictor-of-the-progression-of-early-stage-type-2-diabetic-nephropathy
#1
Jong Ho Kim, Sang Soo Kim, In Joo Kim, Min Jin Lee, Yun Kyung Jeon, Bo Hyun Kim, Sang Heon Song, Yong Ki Kim
AIMS: Multiple biomarkers have emerged as a reliable predictor of the progression of diabetic nephropathy. The aim of this study was to pursue a more simple and practical predictor that can be applied in clinical practice. METHODS: The urine albumin-to-creatinine ratio (ACR), the nonalbumin protein-to-creatinine ratio (NAPCR), and the levels of six biomarkers were measured in 73 patients with type 2 diabetes and estimated glomerular filtration rates (eGFRs)≥60mL/min/1...
November 12, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27908605/direct-health-care-costs-associated-with-obesity-in-chinese-population-in-2011
#2
Jingcheng Shi, Yao Wang, Wenwei Cheng, Hui Shao, Lizheng Shi
AIMS: Overweight and obesity are established major risk factors for type 2 diabetes, and major public health concerns in China. This study aims to assess the economic burden associated with overweight and obesity in the Chinese population ages 45 and older. METHODS: The Chinese Health and Retirement Longitudinal Study (CHARLS) in 2011 included 13,323 respondents of ages 45 and older living in 450 rural and urban communities across China. Demographic information, height, weight, direct health care costs for outpatient visits, hospitalization, and medications for self-care were extracted from the CHARLS database...
November 12, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27899247/association-of-plasma-fetuin-a-levels-with-peripheral-arterial-disease-and-lower-extremity-arterial-calcification-in-subjects-with-type-2-diabetes-mellitus
#3
Ioanna Eleftheriadou, Pinelopi Grigoropoulou, Alexander Kokkinos, Iordanis Mourouzis, Despoina Perrea, Nicholas Katsilambros, Petros P Sfikakis, Nikolaos Tentolouris
AIMS: Fetuin-A is a hepatic glycoprotein that is involved in insulin resistance and atherosclerosis. Herein we examined the association of plasma fetuin-A levels with peripheral arterial disease (PAD) in patients with type 2 diabetes mellitus (T2DM). MATERIAL AND METHODS: A total of 71 patients with T2DM and 57 non-diabetic individuals were recruited. Diagnosis of PAD was based on the absence of triphasic waveform at pedal arteries, while ankle-brachial index (ABI) was calculated...
November 12, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27913012/hyperglycemic-high-anion-gap-metabolic-acidosis-in-patients-receiving-sglt-2-inhibitors-for-diabetes-management
#4
Juliette Sandifer Kum-Nji, Aidar R Gosmanov, Helmut Steinberg, Samuel Dagogo-Jack
Sodium-glucose cotransporter-2 inhibitors (SGLT-2i) are a class of antidiabetic medications that improve glycemic control via inhibiting the reabsorption of filtered glucose and are approved for use in type 2 diabetes (T2DM). These drugs have recently been associated with euglycemic diabetic ketoacidosis (DKA). An increasing number of cases of SGLT-2i-associated DKA have occurred in patients with T2DM. Herein, we describe five episodes of hyperglycemic DKA in four type 2 diabetes patients receiving SGLT-2i therapy...
November 9, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27894749/the-microbiology-of-diabetic-foot-infections-in-patients-recently-treated-with-antibiotic-therapy-a-prospective-study-from-india
#5
Ashu Rastogi, Suja Sukumar, Abhishek Hajela, Soham Mukherjee, Pinaki Dutta, Sanjay Kumar Bhadada, Anil Bhansali
AIM: Clinicians often treat clinically infected diabetic foot ulcers without information from cultures of the wound. The results of wound cultures may also be affected by previous antibiotic therapy. Thus, we aimed to study the microbial isolates, and antimicrobial sensitivity of previously treated patients with a clinically infected DFU. RESEARCH DESIGN AND METHODS: 293 consecutive patients with clinically infected DFU on prior antimicrobial treatment within the immediate past few days for a duration greater than one week were evaluated for microbial etiology, antibiotic sensitivity and final outcomes...
November 9, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27894750/risk-factors-for-autonomic-and-somatic-nerve-dysfunction-in-different-stages-of-glucose-tolerance
#6
Rumyana Dimova, Tsvetalina Tankova, Velina Guergueltcheva, Ivailo Tournev, Nevena Chakarova, Greta Grozeva, Lilia Dakovska
AIM: The present study evaluates autonomic and somatic nerve function in different stages of glucose tolerance and its correlation with different cardio-metabolic parameters. MATERIAL AND METHODS: Four hundred seventy-eight subjects, mean age 49.3±13.7years and mean BMI 31.0±6.2kg/m2, divided according to glucose tolerance: 130 with normal glucose tolerance (NGT), 227 with prediabetes (125 with impaired fasting glucose (IFG) and 102 with isolated impaired glucose tolerance (iIGT)), and 121 with newly-diagnosed T2D (NDT2D), were enrolled...
November 6, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27884662/integrity-of-central-nervous-function-in-diabetes-mellitus-assessed-by-resting-state-eeg-frequency-analysis-and-source-localization
#7
Jens B Frøkjær, Carina Graversen, Christina Brock, Ahmad Khodayari-Rostamabad, Søren S Olesen, Tine M Hansen, Eirik Søfteland, Magnus Simrén, Asbjørn M Drewes
Diabetes mellitus (DM) is associated with structural and functional changes of the central nervous system. We used electroencephalography (EEG) to assess resting state cortical activity and explored associations to relevant clinical features. Multichannel resting state EEG was recorded in 27 healthy controls and 24 patients with longstanding DM and signs of autonomic dysfunction. The power distribution based on wavelet analysis was summarized into frequency bands with corresponding topographic mapping. Source localization analysis was applied to explore the electrical cortical sources underlying the EEG...
November 6, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27894748/ccr5-%C3%AE-32-gene-polymorphism-is-related-to-celiac-disease-and-autoimmune-thyroiditis-coincidence-in-patients-with-type-1-diabetes
#8
Bartosz Słomiński, Urszula Ławrynowicz, Jolanta Myśliwska, Monika Ryba-Stanisławowska, Maria Skrzypkowska, Małgorzata Myśliwiec, Agnieszka Brandt
AIM: The aim of the study was to assess the relationship between CCR5-Δ32 polymorphism and the coincidence of celiac and autoimmune thyroid diseases with type 1 diabetes mellitus (T1D) in children. METHODS: 420 children with T1D aged 15.5±3.0years and 350 healthy controls were studied. Characterization of CCR5-Δ32 genotypes (rs333) was analyzed by polymerase chain reaction (PCR). RESULTS: The allele frequency was significantly different in diabetic children as compared to the healthy controls (p<0...
November 3, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27884663/early-impairment-in-left-ventricular-longitudinal-systolic-function-is-associated-with-an-increased-risk-of-incident-atrial-fibrillation-in-patients-with-type-2-diabetes
#9
Stefano Bonapace, Filippo Valbusa, Lorenzo Bertolini, Luciano Zenari, Guido Canali, Giulio Molon, Laura Lanzoni, Antonella Cecchetto, Andrea Rossi, Alessandro Mantovani, Giacomo Zoppini, Enrico Barbieri, Giovanni Targher
AIMS: It is known that type 2 diabetic patients are at high risk of atrial fibrillation (AF). However, the early echocardiographic determinants of AF vulnerability in this patient population remain poorly known. METHODS: We followed-up for 2years a sample of 180 consecutive outpatients with type 2 diabetes, who were free from AF and ischemic heart disease at baseline. All patients underwent a baseline echocardiographic-Doppler evaluation with tissue Doppler and 2-D strain analysis...
November 3, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27914731/self-management-in-patients-with-diabetes-and-chronic-kidney-disease-is-associated-with-incremental-benefit-in-hrqol
#10
Edward Zimbudzi, Clement Lo, Sanjeeva Ranasinha, Peter G Kerr, Timothy Usherwood, Alan Cass, Gregory R Fulcher, Sophia Zoungas
AIMS: There is insufficient and inconsistent data regarding the association between diabetes self-management, the process of facilitating the knowledge, skill, and ability necessary for diabetes self-care, and health-related quality of life (HRQOL) in people with diabetes and moderate to severe chronic kidney disease (CKD). METHODS: In a cross sectional study, participation in diabetes self-management assessed by the Summary of Diabetes Self-Care Activities (SDSCA) questionnaire and HRQOL was examined in 308 patients with diabetes and CKD (stages 3 to 5) recruited from outpatient diabetes and renal clinics of 4 public tertiary hospitals...
October 29, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27884661/association-of-kidney-disease-measures-with-risk-of-renal-function-worsening-in-patients-with-hypertension-and-type-2-diabetes
#11
Francesca Viazzi, Pamela Piscitelli, Carlo Giorda, Antonio Ceriello, Stefano Genovese, Giuseppina T Russo, Paola Fioretto, Pietro Guida, Salvatore De Cosmo, Roberto Pontremoli
AIMS: To assess the role of kidney disease measures on the development of chronic kidney disease (CKD) in patients with type 2 diabetes (T2D) and hypertension (HT). METHODS: Clinical records from a total of 17,160 patients with T2D and HT, a baseline estimated glomerular filtration rate (eGFR) values ≥60mL/min/1.73m(2), evaluation for albuminuria and regular visits during a four-year follow-up were retrieved and analyzed. The incidence of eGFR <60mL/min/1.73m(2) and/or a reduction >30% from baseline was evaluated...
October 29, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27863973/white-blood-cell-subtypes-and-risk-of-type-2-diabetes
#12
Hongmei Zhang, Zhen Yang, Weiwei Zhang, Yixin Niu, Xiaoyong Li, Li Qin, Qing Su
OBJECTIVE: It is reported that total white blood cell is associated with risk of diabetes mellitus. The present study is to investigate the relationship of white blood cell subsets with incidence of type 2 diabetes at baseline and 3year follow-up. METHODS: We chose individuals without diabetes history as our study population; 8991 individuals were included at baseline. All of the participants underwent a 75-g OGTT at baseline. White blood cell count including all the subsets were measured along with all the other laboratory indices...
October 29, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27847146/skin-autofluorescence-a-marker-for-advanced-glycation-end-products-and-erectile-dysfunction-in-diabetes
#13
Youssef Kouidrat, Ahmad Zaitouni, Ali Amad, Momar Diouf, Rachel Desailloud, Gwenole Loas, Jean-Daniel Lalau
AIM: Although diabetes-related erectile dysfunction (ED) has many etiological factors, little is known about the putative pathophysiological role of advanced glycation end products (AGEs). Skin autofluorescence is a noninvasive marker of AGEs. Recent studies have evidenced a relationship between skin autofluorescence and several complications of diabetes. We hypothesized that AGEs (assessed by skin autofluorescence) are associated with ED in diabetes patients. METHODS: Between March 2014 and April 2015, 42 patients with type 1 diabetes (T1D) and 44 patients with type 2 diabetes (T2D) were consecutively enrolled in a descriptive, cross-sectional study and compared to 54 healthy controls...
October 29, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27866700/angiopoietin-related-growth-factor-is-independently-associated-with-lower-extremity-peripheral-arterial-disease
#14
Hao Nie, Yue Liang, Hong-Xia Wang, Hua-Liang Ren, Yue-Wei Wang, Fang-Da Li, Yue-Hong Zheng
AIMS: The present study investigated the association of serum levels of angiopoietin-related growth factor (AGF) with lower extremity peripheral arterial disease (LEPAD). METHODS: The study group is comprised of 105 patients with lower extremity peripheral arterial disease. The control group consisted of 80 individuals without lower extremity peripheral arterial disease. Serum AGF concentrations were determined by enzyme-linked immunosorbent assay. The relationship between AGF and clinical and biochemical parameters was studied...
October 27, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27838100/renal-pathological-implications-in-type-2-diabetes-mellitus-patients-with-renal-involvement
#15
Li Li, Xiuhui Zhang, Zhicheng Li, Rui Zhang, Ruikun Guo, Qinghua Yin, Lichuan Yang, Rongzheng Yue, Baihai Su, Songmin Huang, Huan Xu, Cijiang He, Fang Liu
AIMS: To investigate the renal pathological implications in type 2 diabetes mellitus patients with renal involvement. METHODS: A total of 328 type 2 diabetes mellitus (T2DM) patients with renal involvement who underwent a renal biopsy and received follow-up for at least one year were recruited in our study. The patients were divided into the diabetic nephropathy (DN), non-diabetic renal disease (NDRD), and NDRD superimposed on DN groups based on the pathological diagnosis...
October 26, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27838099/the-cardiometabolic-risk-profile-of-chinese-adults-with-diabetes-a-nationwide-cross-sectional-survey
#16
Lin Ding, Yu Xu, Limin Wang, Min Xu, Yong Jiang, Mei Zhang, Yichong Li, Jieli Lu, Tiange Wang, Meng Dai, Di Zhang, Weiqing Wang, Wenhua Zhao, Linhong Wang, Yufang Bi, Guang Ning
AIMS: We aimed to estimate the cardiometabolic risk profile of Chinese adults with diabetes. METHODS: We conducted a nationally representative survey of 98,658 noninstitutionalized Chinese adults aged ≥18years using a complex, multistage, probability sampling design in 2010. Diabetes was defined in 12,607 participants according to the 2010 American Diabetes Association criteria. All estimates were weighted to represent the overall Chinese adults with diabetes...
October 26, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27839921/assessment-of-insulin-sensitivity-by-the-hyperinsulinemic-euglycemic-clamp-comparison-with-the-spectral-analysis-of-photoplethysmography
#17
Aglecio Luiz De Souza, Gisele Almeida Batista, Sarah Monte Alegre
AIMS: We compare spectral analysis of photoplethysmography (PTG) with insulin resistance measured by the hyperinsulinemic euglycemic clamp (HEC) technique. MATERIAL AND METHOD: A total of 100 nondiabetic subjects, 43 men and 57 women aged 20-63years, 30 lean, 42 overweight and 28 obese were enrolled in the study. These patients underwent an examination with HEC, and an examination with the PTG spectral analysis and calculation of the PTG Total Power (PTG-TP). Receiver-operating characteristic (ROC) curves were constructed to determine the specificity and sensitivity of PTG-TP in the assessment of insulin resistance...
October 24, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27838098/chronic-low-back-pain-in-adult-with-diabetes-nhanes-2009-2010
#18
Ahmed Hassoon, Mohamad Bydon, Panagiotis Kerezoudis, Patrick R Maloney, Lorenzo Rinaldo, Hsin-Chieh Yeh
: The aim of this study was to test the hypothesis that diabetes mellitus (DM) is associated with an increased prevalence of chronic low back pain (CLBP) in the general population. We analyzed data for 5106 adults (4591 without DM & 515 with diagnosed DM), who were part of the National Health and Nutrition Examination Survey (NHANES) from 2009 through 2010. Adults with DM were older (mean age 54.2years' vs. 42.1years), more likely to be obese (BMI>30, 69.5% vs. 33.3%), less educated (college or above 44...
October 24, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27914732/interaction-of-sex-steroid-hormones-and-obesity-on-insulin-resistance-and-type-2-diabetes-in-men-the-third-national-health-and-nutrition-examination-survey
#19
Ji Li, Hong Lai, Shaoguang Chen, Hong Zhu, Shenghan Lai
AIMS: We examined interaction of sex steroid hormones and obesity with regard to insulin resistance (IR) and type 2 diabetes (T2D) by using nationally representative data from the US. METHODS: Data of 1461 men aged ≥20years who participated in the Third National Health and Nutrition Examination Survey were analyzed. Multiplicative interaction was calculated by cross-product interaction terms in multivariable logistic regression models. Additive interaction was assessed by the relative excess risk due to interaction (RERI)...
October 22, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27836681/vegf-and-the-diabetic-kidney-more-than-too-much-of-a-good-thing
#20
REVIEW
Syamantak Majumder, Andrew Advani
Over a decade and a half has passed since the publication of early reports hinting at a pathogenetic role for vascular endothelial growth factor ("VEGF") in the development of diabetic kidney disease. In diabetic rats, renal mRNA levels of the VEGF-A isoform were upregulated and administration of a VEGF-A neutralizing antibody attenuated albuminuria: VEGF was "bad" in diabetic nephropathy. Since that time, our understanding of the complexity of the renal VEGF system has advanced. Unlike its experimental counterpart, human diabetic nephropathy is associated with diminished VEGF-A levels and experience in the oncological setting has taught us that VEGF blocking therapy can cause adverse renal effects in patients...
October 22, 2016: Journal of Diabetes and its Complications
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