Marina Villanueva-Paz, David Cotán, Juan Garrido-Maraver, Manuel Oropesa-Ávila, Mario de la Mata, Ana Delgado-Pavón, Isabel de Lavera, Elizabet Alcocer-Gómez, Mónica Álvarez-Córdoba, José A Sánchez-Alcázar
In eukaryotic cells, AMP-activated protein kinase (AMPK) generally promotes catabolic pathways that produce ATP and at the same time inhibits anabolic pathways involved in different processes that consume ATP. As an energy sensor, AMPK is involved in the main cellular functions implicated in cell fate, such as cell growth and autophagy.Recently, AMPK has been connected with apoptosis regulation, although the molecular mechanism by which AMPK induces and/or inhibits cell death is not clear.This chapter reviews the essential role of AMPK in signaling pathways that respond to cellular stress and damage, highlighting the complex and reciprocal regulation between AMPK and their targets and effectors...
2016: EXS