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https://www.readbyqxmd.com/read/30333428/destructive-thyroiditis-induced-by-lenvatinib-in-three-patients-with-hepatocellular-carcinoma
#1
Masashi Hirooka, Hironori Ochi, Atsushi Hiraoka, Yohei Koizumi, Bunzo Matsuura, Kouji Joko, Kojiro Michitaka, Masanori Abe, Yoichi Hiasa
Hypothyroidism is a frequently occurring complication in patients on lenvatinib treatment. However, little is known about lenvatinib-induced thyrotoxicosis and destructive thyroiditis. We herein report the cases of three patients who developed hyperthyroidism during the course of lenvatinib treatment. All patients had multiple hepatocellular carcinoma of Child-Pugh class A. Two patients required beta blockers for the management of palpitations. One patient developed hyperthyroidism only one week after the initiation of lenvatinib treatment...
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30333427/esophageal-adenocarcinoma-originating-from-the-esophageal-gland-duct
#2
Mitsuhiro Kono, Yasuaki Nagami, Masahiko Ohsawa, Yasuhiro Fujiwara
No abstract text is available yet for this article.
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30333426/exome-sequencing-reveals-a-novel-homozygous-frameshift-mutation-in-the-cyp7b1-gene-in-a-japanese-patient-with-spg5
#3
Haitian Nan, Keisuke Shimozono, Yuta Ichinose, Mai Tsuchiya, Kishin Koh, Masaki Hiraide, Yoshihisa Takiyama
SPG5 is a rare subtype of autosomal recessive hereditary spastic paraplegia caused by a homozygous mutation in the oxysterol-7a-hydroxylase gene, CYP7B1. We describe the first Japanese patient with SPG5 with a novel mutation in the CYP7B1 gene. On exome sequencing, we identified a homozygous frameshift mutation, c.741delA, p.K247fs, in exon 3 of the CYP7B1 gene. The patient showed spastic paraparesis with white matter hyperintensities in the bilateral corona radiata and periventricular and subcortical regions on brain magnetic resonance imaging...
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30333425/hepatic-portal-venous-gas-following-colonic-endoscopic-submucosal-dissection
#4
Sho Suzuki, Yoji Takeuchi, Ryu Ishihara, Hiroshi Kawakami
No abstract text is available yet for this article.
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30333424/clinical-questions-and-an-inquiring-mind-for-patients-with-igg4-related-disease
#5
Motohisa Yamamoto, Hiroki Takahashi
No abstract text is available yet for this article.
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30333423/the-intrarenal-renin-angiotensin-system-is-activated-immediately-after-kidney-donation-in-kidney-transplant-donors
#6
Naro Ohashi, Shinsuke Isobe, Takashi Matsuyama, Sayaka Ishigaki, Takahisa Suzuki, Takayuki Tsuji, Atsushi Otsuka, Akihiko Kato, Hideaki Miyake, Hideo Yasuda
Objective The intrarenal renin-angiotensin system (RAS) is activated in clinical settings, such as chronic kidney disease (CKD), as well as in CKD animal models, and kidney transplant donors have a greater risk of end-stage renal disease than healthy controls. However, whether or not the intrarenal RAS is activated immediately after kidney donation in kidney transplant donors is unclear, and the mechanism underlying intrarenal RAS activation is unknown. Methods We investigated 10 kidney transplant donors (4 men and 6 women, 58...
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30333422/systemic-lupus-erythematosus-associated-with-ovarian-cancer
#7
Mayu Yagita, Saori Hata, Hiromi Miyata, Hiroko Kakita, Tatsuo Tsukamoto, Eri Muso, Masaaki Fujita
Systemic lupus erythematosus may be associated with various types of malignancy. However, systemic lupus erythematosus occurring with ovarian cancer seems rare, and reliable therapeutic approaches for such cases have yet to be identified. We herein report a case of systemic lupus erythematosus with ovarian cancer that was successfully treated with corticosteroid, plasmapheresis and chemotherapy. This case may provide new insights into treatment approaches for systemic lupus erythematosus with ovarian cancer...
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30333421/usefulness-of-capsule-endoscopy-and-double-balloon-enteroscopy-for-the-diagnosis-of-multiple-carcinoid-tumors-in-the-small-intestine-case-reports-and-a-literature-review
#8
Kentaro Tominaga, Kenya Kamimura, Junji Yokoyama, Shuji Terai
The incidence of carcinoid tumor in the small intestine is increasing; however, its preoperative diagnosis is difficult. We recently experienced three cases of multiple carcinoid tumors in the small intestine successfully detected using capsule endoscopy (CE), followed by a pathological diagnosis using double-balloon enteroscopy (DBE). To diagnose multiple carcinoid in the small intestine appropriately, we reviewed the information of five cases reported to date along with our three recent cases. The literature review demonstrated that CE and DBE are useful for detecting and diagnosing small intestinal carcinoids and tumor multiplicity, which aids in determining the appropriate resection range...
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30333420/a-case-of-hypophosphatemic-osteomalacia-associated-with-adefovir-induced-fanconi-syndrome-initially-diagnosed-as-diabetic-kidney-disease-and-vitamin-d-deficiency
#9
Ryo Koda, Masafumi Tsuchida, Noriaki Iino, Ichiei Narita
A 68-year-old man with type 2 diabetes mellitus and chronic hepatitis B infection was referred to the nephrology department before planned surgery for hepatocellular carcinoma. He had been receiving low-dose adefovir dipivoxil (ADV) for 11 years. Laboratory findings revealed impaired re-absorption in the proximal renal tubules. He had been diagnosed with diabetic kidney disease and osteomalacia due to vitamin D deficiency; thus, ADV was not discontinued until he was referred to us. In this case, concomitant diabetes mellitus and vitamin D deficiency might have prevented the early diagnosis of ADV-induced Fanconi syndrome...
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30333419/pharmacological-strategies-for-midventricular-obstruction-in-patients-with-hypertrophic-cardiomyopathy
#10
Yuichiro Minami, Nobuhisa Hagiwara
No abstract text is available yet for this article.
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30333418/starvation-induced-liver-enzyme-elevation-after-initiation-of-feeding
#11
Hiroaki Nishioka, Aisa Yoshizaki, Yukihiro Imai, Naoki Higashibeppu
Exacerbation of liver enzymes after the initiation of feeding in malnourished patients is caused by refeeding syndrome or persistent starvation. There are no definite clinical markers for distinguishing between the two conditions. We herein report a 63-year-old woman with starvation-induced liver enzyme elevation. Her body weight was inversely associated with the liver enzyme levels after refeeding, which was a different course from refeeding syndrome. Normalization of liver enzymes ensued as the caloric intake increased and weight gain progressed...
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30333417/left-ventricular-thrombus-in-hypertrophic-cardiomyopathy
#12
Mareomi Hamada
No abstract text is available yet for this article.
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30333416/dabigatran-induced-esophageal-ulcer-at-a-natural-constriction
#13
Sho Sasaki, Jun Nishikawa, Atsushi Goto, Isao Sakaida
No abstract text is available yet for this article.
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30333415/rheumatoid-arthritis-complicated-with-anti-melanoma-differentiation-associated-gene-5-antibody-positive-interstitial-pneumonia-a-case-report
#14
Haruki Matsumoto, Shuzo Sato, Yuya Fujita, Makiko Yashiro-Furuya, Naoki Matsuoka, Tomoyuki Asano, Hiroko Kobayashi, Hiroshi Watanabe, Kiyoshi Migita
Anti-melanoma differentiation-associated gene 5 (MDA5) antibodies are frequently detected in amyopathic dermatomyositis with rapidly progressive interstitial lung disease (RP-ILD). However, the presence of anti-MDA5 antibodies in other connective tissue diseases is not well known. We herein report a case of rheumatoid arthritis complicated with refractory anti-MDA5 antibody-positive ILD. A 75-year-old Japanese woman was referred to our hospital for refractory ILD. Serological testing was positive for anti-MDA5 antibody without any muscle or skin lesions...
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30333414/laterally-spreading-tumor-like-early-cancer-in-ileum
#15
Kaho Yamazaki, Kento Takenaka, Kazuo Ohtsuka
No abstract text is available yet for this article.
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30333413/a-case-of-crohn-s-disease-with-mesalazine-allergy-that-was-difficult-to-differentiate-from-comorbid-ulcerative-colitis
#16
Rumiko Tsuboi, Satohiro Matsumoto, Hiroyuki Miyatani, Hirosato Mashima
An 18-year-old man diagnosed with ileocolonic Crohn's disease with circumferential strictures of the ascending colon started treatment with mesalazine and subsequently underwent right hemicolectomy. After surgery, the patient was started on adalimumab, and the clinical course was favorable. Nine months postoperatively, colonoscopy revealed granular mucosa with circumferential and continuous involvement from the transverse colon down to the rectum, findings which resembled ulcerative colitis. Mesalazine allergy was suspected, and the inflammatory findings resolved after discontinuing mesalazine...
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30333412/rectal-lymphoid-follicle-aphthous-lesions-frequently-progress-to-ulcerative-colitis-with-proximal-extension
#17
Ryohei Hayashi, Yoshitaka Ueno, Shinji Tanaka, Masaki Wakai, Junko Kumada, Akira Fujita, Motonobu Nomura, Shiro Oka, Masanori Ito, Kazuaki Chayama
Objective Rectal lymphoid follicular aphthous (LFA) lesions are related to ulcerative colitis (UC) and can be initial lesions of UC. We investigated the clinical course and prognosis of rectal LFA lesions. Methods This is a retrospective analysis of the clinical records at a single center. Patients or Materials Thirteen consecutive cases with LFA lesions treated at Hiroshima University Hospital between 1998 and 2015 were evaluated. Another 49 consecutive cases with ulcerative proctitis treated in the same period were enrolled as the control group...
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30333411/post-trauma-mycobacterium-avium-chronic-rhinosinusitis-mimicking-a-neoplasm
#18
Tamio Okimoto, Yasuhiko Shimizu, Mamiko Nagase, Takeshi Isobe
No abstract text is available yet for this article.
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30333410/crowned-dens-syndrome-associated-with-hyperuricemia
#19
Yuusaku Sugihara, Hiroko Ogawa, Fumio Otsuka
No abstract text is available yet for this article.
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30333409/the-exacerbation-of-hemicrania-continua-mimics-trigeminal-neuralgia
#20
Yuji Kato, Yumeka Tamai, Takeshi Hayashi, Satoko Mizuno, Norio Tanahashi, Masaki Takao
We report the case of a 46-year-old man with hemicrania continua presenting as exacerbations mimicking trigeminal neuralgia. The patient was tentatively diagnosed with trigeminal neuralgia, and treatment with various combinations of drugs was performed after the onset of pain. However, when the condition of the patient did not improve, we suspected hemicrania continua, and treatment with indomethacin was initiated. There was a marked alleviation of his pain within 24 hours. Thus, clinicians should be aware that the duration and frequency of exacerbations of hemicrania continua are variable...
October 17, 2018: Internal Medicine
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