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ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs

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https://www.readbyqxmd.com/read/30004945/role-of-cardiac-resynchronization-therapy-in-patients-with-left-ventricular-assist-support
#1
Nirav Patel, Jason Gluck, Abhishek Jaiswal
No abstract text is available yet for this article.
July 12, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/30004944/optimal-methods-to-secure-extracorporeal-membrane-oxygenation-bicaval-dual-lumen-cannulae-what-works
#2
Christopher J Tignanelli, Allison Weinberg, Lena M Napolitano
Ambulation while on extracorporeal membrane oxygenation (ECMO) is critical to facilitate native pulmonary recovery for patients with acute respiratory failure and is a prerequisite for listing for lung transplantation to achieve optimal outcomes. The development of a bicaval dual-lumen cannula capable of providing venovenous (VV) ECMO support via the internal jugular vein has greatly facilitated ambulation and rehabilitation programs. But cannula dislodgement is a serious concern with ambulation and rehabilitation, especially when minor cannula migration can significantly impact VV-ECMO flow...
July 12, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/30004943/echo-guided-insertion-of-a-dual-lumen-cannula-for-venovenous-extracorporeal-membrane-oxygenation
#3
Giovanni Cianchi, Chiara Lazzeri, Manuela Bonizzoli, Stefano Batacchi, Adriano Peris
We provide a step-by-step description of the insertion of a dual-lumen cannula, for venovenous extracorporeal membrane oxygenation support and how a close monitoring by combined transthoracic and transesophageal techniques ensures a safe procedure and can promptly detect complications.
July 12, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/30004942/benchtop-von-willebrand-factor-testing-comparison-of-commercially-available-ventricular-assist-devices-and-evaluation-of-variables-for-a-standardized-test-method
#4
Phillip A Coghill, Suren Kanchi, Zheila J Azartash-Namin, James W Long, Trevor A Snyder
Gastrointestinal bleeding occurs in 20-30% of patients receiving ventricular assist devices (VADs) due, in part, to acquired von Willebrand syndrome. We examined factors to optimize a benchtop method to quantify changes in von Willebrand Factor (VWF) multimer distribution and function in VADs, then applied them to evaluate commercially available devices. Human plasma was circulated through flow loops with VADs. Several experimental conditions were examined, including temperature, viscosity, and enzyme inhibition...
July 12, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29952802/shear-mediated-platelet-activation-enhances-thrombotic-complications-in-patients-with-lvad-and-is-reversed-after-heart-transplantation
#5
Filippo Consolo, Giulia Sferrazza, Giulia Motolone, Marina Pieri, Michele De Bonis, Alberto Zangrillo, Alberto Redaelli, Marvin J Slepian, Federico Pappalardo
We present a time-series analysis of shear-mediated platelet activation (SMPA) in a patient supported by a left ventricular assist device (LVAD) who developed recurrent thromboembolic events over the course of support. The patient showed marked alterations of SMPA as quantified via the platelet activity state (PAS) assay. At the time of a first pump thrombosis, PAS was equal to 16.2 ± 2.1%, indicating a significant level of SMPA. A moderate decrease of PAS was observed 30 days after pump exchange (PAS = 9...
June 25, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29952801/pump-position-impacts-heartmate-ii-left-ventricular-assist-device-thrombosis
#6
Ahmet Kilic, John Ransom, Simon Maltais, Benjamin Sun, John W Entwistle, Stephen Bailey, Ranjit John, Charles T Klodell, Igor Gregoric, Brett Sheridan, Joyce Chuang, David J Farrar, Kartik Sundareswaran, Robert Adamson
The PREVENtion of HeartMate II pump Thrombosis through clinical management (PREVENT) study was a multicenter, prospective investigation to evaluate the rate of pump thrombosis (PT) with adoption of a uniform set of surgical and medical practices for left ventricular assist device implantation. We sought to quantify pump position at baseline and retrospectively define a pump position associated with poor clinical outcomes. Chest x-rays at baseline were prospectively obtained per protocol. Pump pocket depth, inflow cannula (IC) angle relative to the pump, and IC angle relative to the vertical were measured...
June 25, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29933250/association-of-inflow-cannula-position-with-left-ventricular-unloading-and-clinical-outcomes-in-patients-with-heartmate-ii-left-ventricular-assist-device
#7
Teruhiko Imamura, Ann Nguyen, Ben Chung, Daniel Rodgers, Nitasha Sarswat, Gene Kim, Jayant Raikhelkar, Sirtaz Adatya, Takeyoshi Ota, Tae Song, Colleen Juricek, Jerry D Estep, Daniel Burkhoff, Valluvan Jeevanandam, Gabriel Sayer, Nir Uriel
The relationship between the HeartMate II left ventricular assist device (LVAD) position and pump thrombosis has been reported. However, further clinical implications of device position are unknown. This study aimed to investigate optimal device position for better left ventricular (LV) unloading and patient prognosis. Patients undergoing a ramp test with right heart catheterization after HeartMate II LVAD implantation were enrolled to this study. Device position was quantified from the chest X-ray obtained at the time of the ramp test: (1) inflow cannula angle relative to horizontal line, (2) pump angle relative to spine, (3) pump depth, (4) angle between inflow cannula and pump, and (5) angle between pump and outflow graft...
June 19, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29901474/solving-the-puzzle-of-the-hematologic-left-ventricular-assist-device-interface-one-piece-at-a-time
#8
Jennifer A Cowger, Keyur B Shah
No abstract text is available yet for this article.
June 11, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29877888/salutary-effects-of-the-pulvad-a-novel-implantable-counterpulsation-assist-device-on-cardiac-mechanoenergetics
#9
Christos Kontogiannis, Dionysios Aravantinos, Ioannis Nanas, Chris J Kapelios, Sotirios Marinakis, Styliani Vakrou, Smaragdi Sarchosi, Despina N Perrea, Jay W Mason, John N Nanas, Konstantinos Malliaras
The pressure unloading left ventricular assist device (PULVAD) is a novel implantable counterpulsation LVAD, designed to provide ventricular unloading with augmentation of LV performance and retention of pulsatility. We assessed the effects of the PULVAD on hemodynamics and LV mechanoenergetics in seven farm pigs with acute ischemic heart failure. The PULVAD was implanted in the thorax and was connected to the ascending aorta. The PULVAD was pneumatically driven by a standard intra-aortic balloon pump console and was electrocardiogram-synchronized to provide LV pressure unloading along with diastolic aortic pressure augmentation...
June 5, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29877887/atrial-fibrillation-is-not-associated-with-thromboembolism-in-left-ventricular-assist-device-patients-a-systematic-review-and-meta-analysis
#10
Veraprapas Kittipibul, Pattara Rattanawong, Jakrin Kewcharoen, Pakawat Chongsathidkiet, Wasawat Vutthikraivit, Napatt Kanjanahattakij
Atrial fibrillation (AF) is a well-established risk factor of thromboembolism (TE). Thromboembolism is one of the most common complications in patients supported by continuous-flow left ventricular assisted devices (CF-LVADs). However, the association between AF and TE complications in this population is controversial. We conducted a systematic review and meta-analysis to assess the association between AF and overall TE, stroke, and device thrombosis events in CF-LVAD patients. We performed a comprehensive literature search through September 2017 in the databases of MEDLINE and EMBASE...
June 5, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29877889/performance-of-noninvasive-assessment-in-the-diagnosis-of-right-heart-failure-after-left-ventricular-assist-device
#11
Joanna M Joly, Ashraf El-Dabh, Ramey Marshell, Arka Chatterjee, Michelle G Smith, Margaret Tresler, James K Kirklin, Deepak Acharya, Indranee N Rajapreyar, José A Tallaj, Salpy V Pamboukian
Right heart failure (RHF) after left ventricular assist device (LVAD) is associated with poor outcomes. Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) defines RHF as elevated right atrial pressure (RAP) plus venous congestion. The purpose of this study was to examine the diagnostic performance of the noninvasive INTERMACS criteria using RAP as the gold standard. We analyzed 108 patients with LVAD who underwent 341 right heart catheterizations (RHC) between January 1, 2006, and December 31, 2013...
June 1, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29863635/wave-intensity-analysis-of-right-ventricular-function-during-pulsed-operation-of-rotary-left-ventricular-assist-devices
#12
J Christopher Bouwmeester, Jiheum Park, John Valdovinos, Pramod Bonde
Changing the speed of left ventricular assist devices (LVADs) cyclically may be useful to restore aortic pulsatility; however, the effects of this pulsation on right ventricular (RV) function are unknown. This study investigates the effects of direct ventricular interaction by quantifying the amount of wave energy created by RV contraction when axial and centrifugal LVADs are used to assist the left ventricle. In 4 anesthetized pigs, pressure and flow were measured in the main pulmonary artery and wave intensity analysis was used to identify and quantify the energy of waves created by the RV...
May 29, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29863634/use-of-an-extracorporeal-centrifugal-pump-with-the-berlin-cannulas
#13
Peter C Chen, Rodrigo Zea-Vera, Cole Burgman, E Dean McKenzie, Barbara Elias, Iki Adachi
The Berlin EXCOR ventricular assist device has become a standard treatment in pediatric bridge to transplantation. Despite its increased use in pediatric heart failure, the patient population supported with this technology continues to suffer from hematologic issues such as postoperative hemorrhage and neurologic dysfunction secondary to thrombotic events. Finding a balance between hemorrhagic and thrombotic risks in the acute postoperative period poses a significant challenge. In this report, we describe our approach using a temporary centrifugal pump connected to cannulas designed for the Berlin EXCOR ventricular assist device...
May 29, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29863633/central-venous-line-and-dialysis-catheter-position-affects-drug-clearance-during-continuous-renal-replacement-therapy-in-an-animal-model
#14
Robert Frithiof, Anna Bandert, Anders Larsson, Miklos Lipcsey, David Smekal
In intensive care, drugs are commonly administered through central venous catheters (CVC). These catheters and central venous dialysis catheters (CVDC) are often placed in the same vessel for practical reasons. The aim of this experimental study was to investigate if the position of CVC and CVDC influences the elimination of infused drugs, during continuous renal replacement therapy (CRRT). In a randomized, cross-over model, anesthetized piglets received both a CVC and a CVDC in a jugular vein. Another CVDC was placed in a femoral vein for comparison...
May 29, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29750685/predicting-plasma-free-hemoglobin-levels-in-patients-due-to-medical-device-related-hemolysis
#15
David M Saylor, Paul W Buehler, Ronald P Brown, Richard A Malinauskas
Blood passage through medical devices can cause hemolysis and increased levels of plasma free hemoglobin (pfH) that may lead to adverse effects such as vasoconstriction and renal tubule injury. Although the hemolytic potential of devices is typically characterized in vitro using animal blood, the results can be impacted by various blood parameters, such as donor species. Moreover, it is unclear how to relate measured in vitro hemolysis levels to clinical performance because pfH accumulation in vivo depends on both hemolysis rate and availability of plasma haptoglobin (Hpt) that can bind and safely eliminate pfH...
May 24, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29863632/quantification-of-pulsed-operation-of-rotary-left-ventricular-assist-devices-with-wave-intensity-analysis
#16
J Christopher Bouwmeester, Jiheum Park, Arnar Geirsson, John Valdovinos, Pramod Bonde
The current generation of left ventricular assist devices (LVADs) provides continuous flow and has the capacity to reduce aortic pulsatility, which may be related to a range of complications associated with these devices. Pulsed LVAD operation using speed modulation presents a mechanism to restore aortic pulsatility and potentially mitigate complications. We sought to investigate the interaction of axial and centrifugal LVADs with the LV and quantify the effects of continuous and pulsed LVAD operations on LV generated wave patterns under different physiologic conditions using wave intensity analysis (WIA) method...
May 23, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29863631/medical-therapy-compared-with-surgical-device-exchange-for-left-ventricular-assist-device-thrombosis-a-systematic-review-and-meta-analysis
#17
Jessica G Y Luc, Vakhtang Tchantchaleishvili, Kevin Phan, Shannon M Dunlay, Simon Maltais, John M Stulak
Pump thrombosis is a major adverse event in patients supported on left ventricular assist devices (LVAD). The aim of this systematic review and meta-analysis was to determine the outcomes of various treatment approaches for pump thrombosis, including surgical or medical therapy. Electronic search was performed to identify all studies in the English literature addressing surgical and medical management of pump thrombosis in the modern LVAD era. All identified articles were systematically assessed for inclusion and exclusion criteria...
May 23, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29863630/real-time-measurement-of-polyvinylpyrrolidone-eluted-from-polysulfone-membrane-dialyzers-based-on-the-ultraviolet-spectrum
#18
Yoshimasa Shimamoto, Seigo Matsushita, Takatoshi Yamamoto, Yuki Nakamura, Aki Kamada, Masahiro Miyata, Koichi Umimoto
The objective of this study was to develop a new method for measuring polyvinylpyrrolidone (PVP) eluted from polysulfone (PSu) membrane dialyzers. The Müller method is generally used for the measurement of PVP, in which the PVP concentration is determined by measuring the absorbance after a red color is generated by the formation of PVP-iodine complexes when iodine is added to a sample. In contrast, our method does not require any reagents and allows real-time measurement of PVP by the ultraviolet absorption spectrum (UV-s method)...
May 23, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29863629/re-clinical-physiology-and-venovenous-extracorporeal-life-support-management-are-inextricably-linked
#19
Chee Kiang Tay, Yang Hyun Cho
No abstract text is available yet for this article.
May 23, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29863628/trends-in-mortality-and-risk-characteristics-of-congenital-diaphragmatic-hernia-treated-with-extracorporeal-membrane-oxygenation
#20
Yigit S Guner, Patrick T Delaplain, Lishi Zhang, Matteo Di Nardo, Thomas Brogan, Yanjun Chen, John P Cleary, Peter T Yu, Matthew T Harting, Henri R Ford, Danh V Nguyen
Although the mortality of infants with congenital diaphragmatic hernia (CDH) has been improving since the late 1990s, this observation has not been paralleled among the CDH cohort receiving extracorporeal membrane oxygenation (ECMO). We sought to elucidate why the mortality rate in the CDH-ECMO population has remained at approximately 50% despite consistent progress in the field by examining the baseline risk profile/characteristics of neonates with CDH before ECMO (pre-ECMO). Neonates with a diagnosis of CDH were identified in the ELSO Registry from 1992 to 2015...
May 23, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
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