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ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs

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https://www.readbyqxmd.com/read/27875369/echocardiography-for-less-invasive-implantation-of-left-ventricular-assist-devices
#1
Harry Magunia, Christian Schlensak, David Schibilsky, Jan N Hilberath, Peter Rosenberger, Martina Nowak-Machen
New surgical techniques aim for less-invasive implantation of left ventricular assist devices (LVAD) via small surgical incision sites. Echocardiography plays an important role during patient selection and guidance of the procedure. The surgical incision site can be identified preoperatively by transthoracic echocardiography. Intraoperative identification of left ventricular apex, de-airing and monitoring heart function is performed by transesophageal echocardiography. This article highlights special echocardiographic considerations during less-invasive LVAD implantation surgeries...
November 21, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27861425/comparative-effectiveness-of-dialyzers-specifically-their-effects-on-response-to-the-erythropoiesis-stimulating-agents
#2
Shakil Aslam, Robert J Kossmann
No abstract text is available yet for this article.
November 16, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27861424/experimental-and-clinical-evaluation-of-pre-dilution-and-post-dilution-continuous-veno-venous-hemofiltration-on-clearance-characteristics
#3
Shinya Chihara, Yoshiki Masuda, Michiaki Yamakage
We compared the clearance characteristics of low to high molecular weight substances during pre- and post-dilution continuous veno-venous hemofiltration (CVVH) in experimental and clinical conditions.Experimental circuits for pre- and post-dilution CVVH were prepared using a test solution containing creatinine (110 Da), inulin (5,000 Da), interleukin (IL)-8 (8,000 Da), IL-6 (22,000 Da), and tumor necrosis factor (TNF)-α (51,000 Da). Quantity of test solution flow and filtration flow (QF) were set to 150 ml/min and 10, 20, and 35 ml/min, respectively...
November 16, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27861423/influence-of-iabp-induced-abdominal-occlusions-on-aortic-hemodynamics-a-patient-specific-computational-evaluation
#4
Maria Vittoria Caruso, Attilio Renzuli, Gionata Fragomeni
Intra-aortic balloon pump (IABP) is used as temporary mechanical assistance in case of cardiovascular diseases, even if different hemodynamic problems and, so, clinical complications may happen, such as the decrease of visceral perfusion. A computational fluid dynamic (CFD) study was carried out in order to investigate the effects of different IABP-induced abdominal occlusions on patient-specific aortic flow. Two possible sizes (25 cm3 and 34 cm3) and two locations (2 cm and 3 cm) of the balloon were compared, modelling four abdominal occlusions and numerically reproducing IAB inflation/deflation behaviour...
November 16, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27861422/mathematical-modeling-of-ventricular-assist-device-function-and-blood-flow-generation-assembling-the-heap-of-stones
#5
Keshava Rajagopal
No abstract text is available yet for this article.
November 16, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27861431/pediatric-artificial-lung-a-low-resistance-pumpless-artificial-lung-alleviates-an-acute-lamb-model-of-increased-right-ventricle-afterload
#6
Fares Alghanem, Benjamin S Bryner, Emilia M Jahangir, Uditha P Fernando, John M Trahanas, Hayley R Hoffman, Robert H Bartlett, Alvaro Rojas-Peña, Ronald B Hirschl
Lung disease in children often results in pulmonary hypertension and right heart failure. The availability of a pediatric artificial lung (PAL) would open new approaches to the management of these conditions by bridging to recovery in acute disease or transplantation in chronic disease. This study investigates the efficacy of a novel PAL in alleviating an animal model of pulmonary hypertension and increased right ventricle afterload.Five juvenile lambs (20-30 Kg) underwent PAL implantation in a pulmonary artery to left atrium configuration...
November 15, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27861430/the-use-of-recombinant-antithrombin-iii-in-pediatric-and-neonatal-ecmo-patients
#7
Deanna R Todd Tzanetos, John Myers, Terri Wells, Dan Stewart, Jeffrey J Fanning, Janice E Sullivan
A retrospective review of 77 pediatric and neonatal ECMO patients who received recombinant antithrombin III (ATIII) for ATIII activity >80% was conducted.Anticoagulation management was per institutional protocol. An ATIII activity >80% was targeted. Diagnosis, reason for ECMO cannulation, blood product usage, heparin dosing, ATIII activity and doses, thrombotic and bleeding complications, hours on ECMO, and mortality were recorded. We calculated patient-level summary statistics and assessed differences between groups using χ2 tests (categorical variables) and Wilcoxon rank sum tests (continuous variables)...
November 15, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27861429/clinical-implications-of-physiological-flow-adjustment-in-continuous-flow-left-ventricular-assist-devices
#8
Vakhtang Tchantchaleishvili, Jessica G Y Luc, Caitlin M Cohan, Kevin Phan, Laila Hübbert, Steven W Day, H Todd Massey
There is increasing evidence for successful management of end-stage heart failure with continuous-flow left ventricular assist device (CF-LVAD) technology. However, passive flow adjustment at fixed CF-LVAD speed is susceptible to flow balancing issues as well as adverse hemodynamic effects relating to the diminished arterial pulse pressure and flow. With current therapy, flow cannot be adjusted with changes in venous return, which can vary significantly with volume status. This limits the performance and safety of CF-LVAD...
November 15, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27861428/hepatogenic-differentiation-of-human-induced-pluripotent-stem-cells-on-collagen-coated-polyethersulfone-nanofibers
#9
Maryam Mahmoodinia Maymand, Hamid Reza Soleimanpour-Lichaei, Abdolreza Ardeshirylajimi, Masoud Soleimani, Samaneh Mirzaei, Athena Hajarizadeh, Maryam Kabir Salmani
Many scientists have been fascinated with Induced pluripotent stem cells (iPSCs) for cell replacement therapies. Nanofibrous biocompatible scaffolds have been shown to promote better cell adhesion and improve stem cell differentiation. In the present study, after fabrication using electrospinning technique and surface modifications, the characteristics of Polyethersulfone (PES) nanofibers were determined by scanning electron microscopy (SEM), ATR-FTIR and MTT assay. Then, the hepatogenic potential of iPSCs was evaluated using Real-Time RT-PCR and immunocytochemistry (ICC) after culture on collagen coated polyethersulfone (PES/COL) scaffolds...
November 15, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27861427/quality-of-life-and-mid-term-survival-of-patients-bridged-with-extracorporeal-membrane-oxygenation-to-left-ventricular-assist-device
#10
Shinya Unai, Kentaro Yamane, Daizo Tanaka, Gary Cook, Hitoshi Hirose, Nicholas C Cavarocchi, John W C Entwistle
Insertion of a left ventricular assist device (LVAD) improves survival and quality of life (QOL) in patients with class IV heart failure failing medical management. However, QOL and survival of patients bridged to LVAD with extracorporeal membrane oxygenation (ECMO) is unknown. Between July 2008 and June 2014, 213 patients underwent insertion of HeartMate II LVAD at 2 VAD centers without a bridge with a temporary VAD. ECMO was used as a bridge prior to LVAD insertion in 22 INTERMACS 1 patients (ECMO-VAD group)...
November 15, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27861426/mastering-mitral-leaflets-coaptation-after-valve-repair-with-adjustable-mitral-annuloplasty-ring-prove-of-concept-in-mock-loop-study
#11
Piergiorgio Tozzi, Daniel Hayoz, Carlo Antona, Gianfranco B Fiore, Giuseppe Siniscalchi, Enrico Ferrari, Gérard Baeriswyl, Riccardo Vismara
This investigation sought to determine the feasibility of a novel mitral ring designed to reshape mitral annulus on beating heart, after surgery. The mitral ring is intended to improve mitral leaflets coaptation to correct residual and recurrent mitral regurgitations. It could also provide progressive correction of mitral regurgitation. The device was tested in ex vivo beating heart model.The novel mitral ring is selectively deformable in P1, P2 and P3 segments using a dedicated angioplasty-type balloon. The deformation should increase leaflets' coaptation reducing distance between the two leaflets...
November 15, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27832004/neurologic-neurocognitive-and-functional-outcomes-in-children-under-6-years-treated-with-the-berlin-heart-excor-ventricular-assist-device
#12
Juliana H VanderPluym, Charlene M T Robertson, Ari R Joffe, Jennifer Conway, Ivan M Rebeyka, David B Ross, Gonzalo Garcia Guerra, Mohammed M Al Aklabi, Holger Buchholz
The objective of this study is to describe the neurologic, neurocognitive and functional outcomes of children aged under 6 years supported on the Berlin Heart EXCOR ventricular assist device (VAD) followed in the Complex Pediatric Therapies Follow-up Program (CPTFP). Sixteen patients were prospectively followed through this longitudinal, developmental program. The patients were evaluated with neurologic physical exam. Intelligence Quotients (IQ) and functional outcome scores (ABAS-II scores) were obtained. Neuroimaging reports from before, during and after VAD implantation were retrospectively reviewed for reported brain injury (BI)...
November 9, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27832003/development-of-a-model-of-pediatric-lung-failure-pathophysiology
#13
John M Trahanas, Fares Alghanem, Catalina Ceballos-Muriel, Hayley R Hoffman, Alice Xu, Kristopher B Deatrick, Marie Cornell, Alvaro Rojas-Pena, Robert H Bartlett, Ronald B Hirschl
A pediatric artificial lung (PAL) is under development as a bridge to transplantation or lung remodeling for children with end-stage lung failure (ESLF). In order to evaluate the efficiency of a PAL, a disease model mimicking the physiologic derangements of pediatric ESLF is needed. Our previous right pulmonary artery ligation (rPA-LM) ovine model achieved that goal, but caused immediate mortality in nearly half of the animals. In this study, we evaluated a new technique of gradual postoperative right pulmonary artery (rPA) occlusion using a Rummel tourniquet (rPA-RT) in seven (25-40 Kg) sheep...
November 9, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27832002/renal-differentiation-of-mesenchymal-stem-cells-seeded-on-nanofibrous-scaffolds-improved-by-human-renal-tubular-cell-lines-conditioned-medium
#14
Abdolreza Ardeshirylajimi, Saeid Vakilian, Mohammad Salehi
Kidney injuries and renal dysfunctions are one of the most important clinical problems and tissue engineering could be a valuable method for solving it. The objective of this study was to investigate the synergistic effect of renal cell line conditioned medium and Polycaprolactone nanofibers on renal differentiation of human mesenchymal stem cells. In the present study, after stem cells isolation and characterization, Polycaprolactone nanofibrous scaffold was fabricated using electrospinning methods and characterized morphologically, mechanically and biocompatibility...
November 9, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27832001/scaling-the-low-shear-pulsatile-torvad-for-pediatric-heart-failure
#15
Jeffrey R Gohean, Erik R Larson, Brian H Hsi, Mark Kurusz, Richard W Smalling, Raul G Longoria
This article provides an overview of the design challenges associated with scaling the low-shear pulsatile TORVAD ventricular assist device (VAD) for treating pediatric heart failure. A cardiovascular system model was used to determine that a 15 ml stroke volume device with a maximum flow rate of 4 L/min can provide full support to pediatric patients with body surface areas between 0.6 to 1.5 m2. Low shear stress in the blood is preserved as the device is scaled down and remains at least two orders of magnitude less than continuous flow VADs...
November 9, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27832000/the-effects-of-propofol-and-isoflurane-sedation-on-the-outcomes-of-surgical-patients-receiving-extracorporeal-membrane-oxygenation-ecmo
#16
Kai Verkoyen, Thomas A Schildhauer, Justus T Strauch, Justyna Swol
This manuscript resurrects a historical technique using a new technology by describing the results of a retrospective, observational, single-center study that investigated the effects of propofol compared to isoflurane sedation on patient outcomes following extracorporeal membrane oxygenation (ECMO). No differences in patient outcomes were observed between the propofol and isoflurane groups. Nevertheless, the results of this study might improve our understanding of the effects of sedation on patient outcomes following ECMO and provide insight into the effects of spontaneous breathing during ECMO...
November 9, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27831999/safety-of-propofol-for-oxygenator-exchange-in-extracorporeal-membrane-oxygenation
#17
Benjamin Hohlfelder, Paul M Szumita, Susan Lagambina, Gerald Weinhouse, Jeremy R DeGrado
The purpose of this analysis is to describe the safety of propofol administration in adult ECMO patients. We performed a prospective cohort analysis of patients utilizing ECMO at Brigham and Women's Hospital between February 2013 and October 2015. Patients were included if they utilized ECMO for at least 48 hours. The major endpoint of the analysis was the median oxygenator lifespan. Oxygenator exchanges were analyzed by the number of patients requiring an oxygenator exchange and the number of oxygenator exchanges per ECMO day...
November 9, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27831998/hemodynamic-performance-of-a-novel-right-ventricular-assist-device-perkat%C3%A2
#18
Daniel Kretzschmar, P Christian Schulze, Markus W Ferrari
Acute right ventricular failure (RVF) is an increasingly clinical problem and a life-threatening condition. Right ventricular assist devices (RVADs) represent a reasonable treatment option for patients with refractory RVF. We here present a novel percutaneously implantable device for RV support.The PERKAT device is based on a nitinol stent cage which is covered with valve- carrying foils. A flexible outlet trunk with a pigtail tip is connected to the distal part. The device is driven by an IABP drive unit which inflates/deflates a standard IABP balloon placed within in the stent cage...
November 9, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27831997/pulmonary-arterial-compliance-improves-rapidly-after-left-ventricular-assist-device-implantation
#19
S Carolina Masri, Ryan J Tedford, Monica M Colvin, Peter J Leary, Rebecca Cogswell
Pulmonary artery compliance (PAC) contributes to right ventricular (RV) afterload, is decreased in the setting of increased left ventricular (LV) filling pressures, and may be an important component of World Health Organization (WHO) Group II Pulmonary Hypertension (PH). Left ventricular assist device (LVAD) implantation can rapidly change LV filling, but its relationship with PAC is unknown. Right heart catheterization was performed pre-operatively, post-operatively (between 48-72 hours), and > 30 days post-LVAD implantation in a cohort of 64 patients with end stage systolic heart failure...
November 9, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27748657/myocardial-recovery-in-peripartum-cardiomyopathy-after-hyperprolactinemia-treatment-on-bivad
#20
Dominik Wiedemann, Thomas Schlöglhofer, Julia Riebandt, Markus Neuner, Edda Tschernko, Heinrich Schima, Daniel Zimpfer
Peripartum cardiomyopathy requiring mechanical ciruculatory support is rare however it is a lifethreatening disease with recovery rates poorer than expected. Herein we describe a case of successfull recovery of a patient with peripartum cardiomyopathy. Implantation of a biventricular ventricular assist device was performed, additonally the patient's hyperprolactinemia was treated with Cabergoline resulting in a fast complete restoration of ventricular function.
September 22, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
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