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Dermatology: International Journal for Clinical and Investigative Dermatology

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https://www.readbyqxmd.com/read/27883996/phototherapy-with-narrow-band-uvb-in-adult-guttate-psoriasis-results-and-patient-assessment
#1
Montserrat Fernández-Guarino, Sonsoles Aboín-González, Diana Velázquez, Lucia Barchino, Natividad Cano, Pablo Lázaro
BACKGROUND: Acute guttate psoriasis (AGP) is a distinctive clinical entity with good response to treatment with narrow-band ultraviolet B (NB-UVB). OBJECTIVE: To investigate the results of NB-UVB phototherapy in adult patients with adult guttate psoriasis. MATERIAL AND METHODS: We carried out a prospective, open, and observational study. Patients over 18 years with more than 5% of body surface area affected were included. The PASI was assessed prior to and after treatment...
November 25, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27875814/characterisation-of-prognosis-and-invasion-of-cutaneous-squamous-cell-carcinoma-by-podoplanin-and-e-cadherin-expression
#2
Kristina Hesse, Imke Satzger, Vivien Schacht, Brigitta Köther, Uwe Hillen, Joachim Klode, Katrin Schaper, Ralf Gutzmer
BACKGROUND: Around 5% of all cutaneous squamous cell carcinoma (cSCC) metastasise. Metastases usually locate in regional skin and lymph nodes, suggesting collective cancer invasion. The cellular level of tumour invasion and prognostic parameters remain to be characterised. METHODS: We performed immunohistochemical analyses of E-cadherin (marker for collective cancer invasion) and podoplanin (marker for epithelial-mesenchymal transition [EMT], single-cell invasion) expression in 102 samples of metastatic and non-metastatic cSCC and 18 corresponding skin and lymph node metastases to characterise the invasion of cSCC...
November 23, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27871068/autoinflammatory-skin-disease-a-review-of-concepts-and-applications-to-general-dermatology
#3
Aditi S Murthy, Kieron Leslie
We provide an up-to-date summary of important concepts of autoinflammation as well as describe important but rare monogenic autoinflammatory disorders that may present with cutaneous findings. Finally, of particular interest to a practicing general dermatology audience, we review concepts of autoinflammation as they apply to understanding the disease pathogenesis of common skin disorders.
November 22, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27811471/systematic-review-of-health-related-quality-of-life-in-adolescents-with-psoriasis
#4
Jessica Gonzalez, Kiera Cunningham, Jason Perlmutter, Alice Gottlieb
BACKGROUND: Many cases of psoriasis begin in adolescence. The affected adolescents face the combined physical and psychosocial challenges of their disease-free peers with the added complexity of a visible disease. OBJECTIVE: To review the impact of psoriasis on the health-related quality of life (HRQL) in adolescents as compared to their peers with other chronic diseases and to determine the best tools to measure HRQL in this population. METHODS: A systematic literature review was completed using PubMed...
November 4, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27698327/efficacy-of-dapsone-in-the-treatment-of-pemphigus-vulgaris-a-single-center-case-study
#5
Sharon Baum, Assaf Debby, Sarit Gilboa, Henri Trau, Aviv Barzilai
BACKGROUND: Pemphigus vulgaris (PV) is a chronic autoimmune blistering disease. Most patients require long-term therapy with systemic steroids, and a steroid-sparing agent is usually also utilized. Dapsone is a chemotherapeutic agent with anti-inflammatory properties that is used as a steroid-sparing agent in PV. OBJECTIVE: The aim of the present study was to evaluate the efficacy of dapsone as an adjuvant therapy in patients with PV. METHODS: A retrospective analysis of patients' files was performed...
October 4, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27684441/hospitalisations-with-hidradenitis-suppurativa-an-increasing-problem-that-deserves-closer-attention
#6
João Vasco Santos, Carmen Lisboa, Caterina Lanna, Altamiro Costa-Pereira, Alberto Freitas
BACKGROUND/AIMS: Hidradenitis suppurativa (HS), a chronic inflammatory skin disease of the hair follicle, can lead to scarring and disability. With an estimated European prevalence of 1%, few epidemiological studies of HS have been performed, and none focused on hospitalisations. We aimed to study the time trends of HS hospitalisations and to evaluate the demographic characteristics, hospital incidence rate, readmissions, length of stay, comorbidities and risk factors of hospitalised HS patients...
September 30, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27676268/surgical-treatment-of-facial-basal-cell-carcinoma-patient-based-assessment-of-clinical-outcome-in-a-prospective-cohort-study
#7
Joséphine Ofaiche, Raphael Lopez, Emilie Bérard, Aymeric André, Cristina Bulai-Livideanu, Thomas Méresse, Benjamin B Vairel, Jean-Louis Grolleau, Carle Paul, Nicolas Meyer
BACKGROUND: There are limited data on the esthetic, functional, and morphological outcomes of surgical treatment of facial basal cell carcinoma (BCC). OBJECTIVE: The aim of our study was to assess the determinants of the evaluation of both the patients and the investigator of the esthetic, functional, and morphological impact of the surgical treatment of facial BCC. METHODS: A prospective observational study evaluated 111 patients treated surgically for facial BCCs (n = 135 BCCs), using the Patient and Observer Scar Assessment Scale (POSAS), a validated and reliable scale designed for the evaluation of all types of scars by professionals and patients...
September 28, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27649417/high-prevalence-of-back-pain-and-axial-spondyloarthropathy-in-patients-with-hidradenitis-suppurativa
#8
Sylke Schneider-Burrus, Ellen Witte-Haendel, Demetrios Christou, Benedetta Rigoni, Robert Sabat, Gerd Diederichs
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory disease, causing fistulating sinuses in the intertriginous skin of axillary, genitofemoral and perianal sites. OBJECTIVE: As other chronic inflammatory diseases, e.g. psoriasis, are frequently associated with spondyloarthropathies (SpA), the goal of this study was to quantify the prevalence of back pain and SpA in HS patients. METHODS: A prospective questionnaire survey in 100 HS patients and a retrospective evaluation of pelvic magnetic resonance imaging (MRI) scans in 46 HS patients were conducted...
September 21, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27622522/calciphylaxis-and-martorell-hypertensive-ischemic-leg-ulcer-same-pattern-one-pathophysiology
#9
Jürg Hafner
This review presents a closer look at four diseases which are probably closely related to one another pathophysiologically: (a) calciphylaxis (distal pattern); (b) calciphylaxis (proximal pattern); (c) Martorell hypertensive ischemic leg ulcer; (d) calciphylaxis with normal renal and parathyroid function (synonym: eutrophication). The four diseases have largely the same risk factors: (1) arterial hypertension, (2) diabetes mellitus (types 1 and 2), (3) secondary or tertiary hyperparathyroidism (in end-stage kidney disease) and (4) oral anticoagulation with vitamin K antagonists...
September 14, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27603174/quality-of-life-impairment-in-children-and-adults-with-vitiligo-a-cross-sectional-study-based-on-dermatology-specific-and-disease-specific-quality-of-life-instruments
#10
Juliana Catucci Boza, Natalia Giongo, Priscilla Machado, Roberta Horn, Amanda Fabbrin, Tania Cestari
BACKGROUND: Vitiligo can negatively affect a patient's quality of life (QoL). A specific questionnaire has been developed and validated in the English language: the vitiligo-specific quality-of-life instrument (VitiQoL). The instrument was translated, culturally adapted and validated into Brazilian Portuguese (VitiQoL-PB). OBJECTIVE: The aim of this study was to assess the QoL in adult patients through the VitiQoL and Dermatology Life Quality Index (DLQI) and in pediatric patients through the Children's Dermatology Life Quality Index (CDLQI) in a sample of patients with vitiligo...
September 8, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27603046/sensitivity-of-the-gepard-patient-questionnaire-to-identify-psoriatic-arthritis-in-patients-with-psoriasis-in-daily-practice-the-gepard-life-study
#11
Peter Härle, Katrin Letschert, Bianca Wittig, Ulrich Mrowietz
Early detection of psoriatic arthritis (PsA) remains a challenge in clinical practice. Tools such as the German Psoriasis Arthritis Diagnostic (GEPARD) questionnaire have been developed for this purpose. The aim of this study was to determine the performance of the GEPARD questionnaire in the detection of PsA in psoriasis patients following rheumatology evaluation in daily clinical practice in Germany. This was a multicenter study involving 59 dermatology units (university/general hospital/office based), and the GEPARD questionnaire was distributed to psoriasis patients...
September 8, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27592104/topical-timolol-maleate-0-5-for-infantile-hemangioma-its-effectiveness-compared-to-ultrapotent-topical-corticosteroids-a-single-center-experience-of-278-cases
#12
Retno Danarti, Lukman Ariwibowo, Sunardi Radiono, Arief Budiyanto
BACKGROUND: Infantile hemangioma (IH) may have implications on parental distress and cosmetic disfigurement. To date, ultrapotent corticosteroids are used as a treatment of choice for superficial IH. However, due to their side effects and sometimes lack of IH regression, it is necessary to find alternative topical therapies. Timolol maleate 0.5% solution and gel are nonselective β-blockers that could inhibit proliferation and trigger regression of IH. OBJECTIVE: To evaluate the efficacy of topical ultrapotent corticosteroids and timolol maleate 0...
September 3, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27591988/il17a-and-il17f-gene-polymorphism-association-with-psoriasis-risk-and-response-to-treatment-in-a-polish-population
#13
Monika Białecka, Roksana Ostasz, Mateusz Kurzawski, Adam Klimowicz, Honorata Fabiańczyk, Piotr Bojko, Violetta Dziedziejko, Krzysztof Safranow, Anna Machoy-Mokrzyńska, Marek Droździk
BACKGROUND: Recent studies have revealed the pivotal role of Th17 cells and interleukin-17 (IL-17) in plaque psoriasis development and treatment outcome. The IL-17 family consists of 6 structurally related cytokines (IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, IL-17F), of which IL-17A and IL-17F mediate similar biological effects. OBJECTIVES: The aim of this study was to evaluate an association between the IL17A (-197G>A; rs2275913) and IL17F (rs763780: T>C; rs11465553: G>A; rs2397084: T>C) polymorphisms with psoriasis susceptibility as well as response to topical and combined topical with narrow-band ultraviolet B (NB-UVB) therapy in a Polish population...
September 3, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27576462/prevalence-and-characteristics-of-hyperhidrosis-in-sweden-a-cross-sectional-study-in-the-general-population
#14
Alexander Shayesteh, Urban Janlert, Christine Brulin, Jens Boman, Elisabet Nylander
BACKGROUND: Hyperhidrosis is defined as excessive sweating which can be primary or secondary. Data about the prevalence of primary hyperhidrosis are scarce for northern Europe. OBJECTIVE: Our aim was to investigate the prevalence of hyperhidrosis focusing on its primary form and describe the quality of life impairments for the affected individuals. METHODS: Five thousand random individuals aged 18-60 years in Sweden were investigated. The individuals' addresses were obtained from Statens personadressregister, SPAR, which includes all persons who are registered as resident in Sweden...
September 1, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27576321/assessment-of-the-effects-of-rituximab-monotherapy-on-different-subsets-of-circulating-t-regulatory-cells-and-clinical-disease-severity-in-severe-pemphigus-vulgaris
#15
Rajsmita Bhattacharjee, Dipankar De, Sanjeev Handa, Ranjana W Minz, Biman Saikia, Neha Joshi
BACKGROUND: Robust evidence for the efficacy of rituximab monotherapy in pemphigus is lacking. The effects of rituximab on T-regulatory cells (Tregs) in pemphigus have not been studied. OBJECTIVE: The primary objective was to assess the efficacy of rituximab monotherapy in severe pemphigus vulgaris. The secondary objectives were to assess whether counts of different subsets of Tregs in the peripheral blood correlate with baseline clinical severity and whether clinical response in severe pemphigus is associated with an alteration in the Treg count...
September 1, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27513583/preface
#16
Günther F L Hofbauer
No abstract text is available yet for this article.
August 11, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27513525/title-page-table-of-contents
#17
(no author information available yet)
No abstract text is available yet for this article.
August 11, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27648565/erratum
#18
(no author information available yet)
No abstract text is available yet for this article.
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27578305/a-randomized-split-face-clinical-trial-of-photodynamic-therapy-with-methyl-aminolevulinate-versus-ingenol-mebutate-gel-for-the-treatment-of-multiple-actinic-keratoses-of-the-face-and-scalp
#19
Cristina Zane, Antonella Fabiano, Mariachiara Arisi, Piergiacomo Calzavara-Pinton
BACKGROUND: Photodynamic therapy with methyl aminolevulinate (MAL-PDT) and ingenol mebutate gel (IMB) are approved therapeutic options for multiple actinic keratoses (AKs). OBJECTIVE: The aim of this intraindividual, split-face, randomized clinical trial was to compare treatment outcomes of MAL-PDT and IMB. METHODS: Two symmetrical contralateral areas with a similar number of AKs were selected and randomly assigned to 3 days of an IMB treatment cycle or a single session of MAL-PDT...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27576734/phenotypic-characterization-of-patients-with-hidradenitis-suppurativa
#20
Dan Lipsker, Jean Revuz
No abstract text is available yet for this article.
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
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