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Dermatology: International Journal for Clinical and Investigative Dermatology

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https://www.readbyqxmd.com/read/29788024/extracorporeal-photopheresis-an-efficacious-and-well-tolerated-treatment-for-cutaneous-and-oral-mucosal-chronic-graft-versus-host-disease
#1
Camille Richet, Anne Huynh, Chloé Dimeglio, Cécile Borel, Benoît Lepage, Serge Boulinguez, Marie Claude Marguery, Carle Paul, Cristina Bulai Livideanu
BACKGROUND: Extracorporeal photopheresis (ECP) is a second-line therapy for steroid-refractory chronic graft-versus-host disease (cGVHD). OBJECTIVE: We describe the long-term efficacy and tolerability of ECP according to the cutaneous phenotype of cGVHD and report on the reduced need for immunosuppressant drugs in this setting. PATIENTS AND METHODS: Fourteen patients (8 females) with cutaneous and/or mucosal cGVHD, treated with ECP between October 2010 and May 2016 within a single center, were included...
May 22, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29758553/a-retrospective-cohort-study-on-patients-with-hidradenitis-suppurativa
#2
S Morteza Seyed Jafari, Evelyne Knüsel, Simone Cazzaniga, Robert E Hunger
BACKGROUND: Hidradenitis suppurativa (HS) is one of the most distressing conditions observed in dermatology and has a substantial negative effect on the quality of life of affected persons. OBJECTIVES: The aim of this study was to evaluate different treatment strategies in patients with HS. METHODS: In a retrospective cohort, all patients with HS (July 2015 to March 2017) were reviewed. Collected data consisted of patients' demographics, clinical characteristics, psychosocial situation, and previous and current treatments...
May 14, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29689550/hidradenitis-suppurativa-associated-with-down-syndrome-is-characterized-by-early-age-at-diagnosis
#3
Giulia Giovanardi, Andrea Chiricozzi, Luca Bianchi, Clara De Simone, Valentina Dini, Chiara Franceschini, Simone Garcovich, Teresa Oranges, Cosimo Di Raimondo, Dante Raffaele Caposiena Caro, Marco Romanelli, Ketty Peris
BACKGROUND/AIMS: The association between hidradenitis suppurativa (HS) and multiple comorbidities has been widely investigated but data about the coexistence of Down syndrome (DS) are scarce. We sought to evaluate the prevalence of DS among a population of HS patients and assess their clinical features. METHODS: We collected demographic and clinical data of patients affected with HS referred to three Italian outpatient dermatology clinics. RESULTS: A total of 257 HS patients were enrolled, 62% females and 38% males (mean age [±SD]: 23...
April 24, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29669340/swiss-german-version-of-the-actinic-keratosis-quality-of-life-questionnaire
#4
Larissa S Meier, Maria Schubert, Yasemin Göksu, Solveig Esmann, Gabrielle R Vinding, Gregor B E Jemec, Günther F L Hofbauer
BACKGROUND: Actinic keratosis (AK) is a sun-induced skin lesion that may progress to invasive squamous cell carcinoma of the skin. Recently, the Actinic Keratosis Quality of Life questionnaire (AKQoL) was designed for patients with AK in Denmark as a specific quality of life instrument for AK patients. OBJECTIVE: The objective of this study was to adapt the AKQoL for the German language region of Switzerland and to evaluate its psychometric properties (validity, reliability)...
April 18, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29566370/dermoscopic-features-of-basal-cell-carcinoma-on-the-lower-limbs-a-chameleon
#5
Mara Lombardi, Riccardo Pampena, Stefania Borsari, Caterina Bombonato, Elisa Benati, Giovanni Pellacani, Caterina Longo
BACKGROUND: Lower limbs represent an uncommon location for basal cell carcinoma (BCC) and only few reports have described dermoscopic features of BCC in this body site. Since BCCs of the lower limbs frequently display nonclassic BCC dermoscopic criteria, they can simulate other benign or malignant lesions. OBJECTIVE: Our aim was to describe the dermoscopic features of BCC located on lower limbs and to define which criteria were more associated with their benign- or malignant-looking appearance...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29237158/dermoscopy-of-morphea-and-cutaneous-lichen-sclerosus-clinicopathological-correlation-study-and-comparative-analysis
#6
Enzo Errichetti, Aimilios Lallas, Zoe Apalla, Alessandro Di Stefani, Giuseppe Stinco
BACKGROUND: Dermoscopy of morphea and cutaneous lichen sclerosus (CLS) has been described by various studies, with none of them considering variability according to clinical phases and investigating dermoscopic-histological correlations. OBJECTIVE: To evaluate dermoscopic features in general and according to clinical stage, identify possible distinctive dermoscopic clues, and assess dermoscopy accuracy in detecting subclinical alterations in morphea and CLS. METHODS: A representative dermoscopic image of target lesions was evaluated for the presence of specific features, correlating them with clinical subtype (inflammatory, inflammatory-sclerotic, sclerotic, or sclerotic-atrophic)...
December 14, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29554651/longitudinal-melanonychia-differences-in-etiology-are-associated-with-patient-age-at-diagnosis
#7
Yi-Teng Tseng, Cher-Wei Liang, Jau-Yu Liau, Koping Chang, Yu-Hsian Tseng, Jau-Shiuh Chen, Yi-Hua Liao
BACKGROUND: Longitudinal melanonychia (LM) may occur as a result of nail apparatus melanoma. Knowledge of etiology plays an important role in the management of LM. OBJECTIVES: The study is aimed to compare the diagnosis of LM in different age groups. METHODS: We collected 63 cases (45 adults and 18 children) with LM who underwent nail matrix biopsy or excision in a 21-year cohort and assessed their clinicopathological features. RESULTS: Melanomas in adults and children were 40% and none, while nevi accounted for 15...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29502116/dermoscopy-improves-the-diagnostic-accuracy-of-melanomas-clinically-resembling-seborrheic-keratosis-cross-sectional-study-of-the-ability-to-detect-seborrheic-keratosis-like-melanomas-by-a-group-of-dermatologists-with-varying-degrees-of-experience
#8
Cristina Carrera, Sonia Segura, Paula Aguilera, Carol Midori Takigami, Antonio Gomes, Alicia Barreiro, Massimiliano Scalvenzi, Caterina Longo, Stefano Cavicchini, Luc Thomas, Josep Malvehy, Susana Puig, Iris Zalaudek
BACKGROUND: Malignant melanomas mimicking seborrheic keratosis (SK-like MMs) carry the risk of delayed diagnosis and inadequate treatment. The value of dermoscopy to improve the correct detection of these mimickers has not been previously studied. OBJECTIVE: To evaluate the diagnostic accuracy of clinically SK-like MMs with and without dermoscopy. METHODS: Clinical and dermoscopic images of histopathologically proven SK-like MMs (n = 134) intermingled with other melanomas and benign tumors were randomly presented to clinicians with different levels of experience, blinded to the diagnosis and goal of the study...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29502112/hyperhidrosis-sweating-sites-matter-quality-of-life-in-primary-hyperhidrosis-according-to-the-sweating-sites-measured-by-sf-36
#9
Alexander Shayesteh, Urban Janlert, Elisabet Nylander
BACKGROUND: Primary hyperhidrosis has negative impacts on quality of life. The aim of this study was to investigate whether the impacts of primary hyperhidrosis on quality of life are different depending on the localisation of the sweating. METHOD: We compiled background data, Hyperhidrosis Disease Severity Scale (HDSS), and Short-Form Health Survey (SF-36) post hoc results from 2 previous studies. Cases who described only 1 site as their most problematic area of sweating were included (n = 160/188) while individuals with multifocal primary sites of hyperhidrosis were excluded (n = 28/188)...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29502111/why-we-should-focus-on-melanoma-targeted-screening-strategies
#10
Cédric Rat, Brigitte Dreno, Jean-Michel Nguyen
No abstract text is available yet for this article.
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29502110/prospective-observational-non-interventional-multicentre-study-on-the-efficacy-and-tolerability-of-a-new-calcipotriol-betamethasone-aerosol-foam-enstilar%C3%A2-in-patients-with-plaque-psoriasis-under-daily-practice-conditions
#11
Sascha Gerdes, Marion Krakor, Tobias Anger, Hans Joachim Hutt, Andreas Körber
BACKGROUND/AIMS: To assess the efficacy and tolerability of the new aerosol foam of calcipotriol 50 µg/g plus betamethasone dipropionate 0.5 mg/g (Cal/BD foam, Enstilar®) in psoriasis vulgaris under daily practice conditions. METHODS: 410 adult psoriasis patients (56% male) from 87 German sites were enrolled in a 4-week, open-label, prospective, non-controlled, observational, non-interventional study. RESULTS: At baseline, patients presented with a psoriasis severity of mild (41...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29495009/hidradenitis-suppurativa-disease-burden-and-etiology-in-skin-of-color
#12
Dylan E Lee, Ashley K Clark, Vivian Y Shi
Hidradenitis suppurativa (HS) is a chronic, debilitating skin disease. Although most studies on HS are conducted in largely Caucasian populations, evidence demonstrates a higher prevalence in patients with skin of color, including African and Hispanic populations. These racial subgroups are likely at risk for greater disease burden due to a higher prevalence of components of the metabolic syndrome, comorbid depression, and low socioeconomic status; however, there is a paucity of research in these populations...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29353270/screening-for-brain-involvement-in-infants-with-multifocal-cutaneous-infantile-hemangiomas
#13
Rivka Friedland, Dan Ben Amitai, Alex Zvulunov
BACKGROUND: Multifocal (≥5) infantile hemangiomas (IHs) are known as a risk factor for extracutaneous involvement. Liver is the most commonly involved organ, but involvement of other systems has also been reported. This study aims to describe the characteristic findings in a group of infants with multiple cutaneous hemangiomas, with emphasis on intracranial involvement. METHODS: A retrospective case series study was carried out in a pediatric dermatology unit of a tertiary pediatric medical center...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29339636/successful-treatment-of-autoimmune-urticaria-with-low-dose-prednisolone-therapy-administered-for-a-few-months-a-case-series-of-42-patients
#14
Krisztina Vas, Anita Altmayer, Lilla Mihályi, Edina Garaczi, Ágnes Kinyó, Eszter Jakobicz, Sándor Husz, Lajos Kemény, Zsuzsanna Bata-Csörgő
BACKGROUND: Chronic spontaneous urticaria (CSU) is defined as symptoms of urticaria persisting for 6 weeks or more without obvious cause. Autologous serum skin test (ASST) positivity in patients with CSU is considered to be associated with autoimmune urticaria (AIU). METHODS: In this retrospective study we retrieved the medical records of 1,073 urticaria patients seen at the Department of Dermatology and Allergology of Szeged University between January 2005 and February 2014...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29320765/emerging-treatment-options-in-atopic-dermatitis-systemic-therapies
#15
Uffe Nygaard, Christian Vestergaard, Mette Deleuran
The pathogenesis of atopic dermatitis (AD) is multifactorial and intricate, and the clinical presentation of the condition varies greatly. Symptoms and severity depend on individual trigger factors and stage of the disease. The majority of AD patients are sufficiently treated with emollients in combination with existing topical or systemic therapies. Yet treatment failure with existing drugs and treatment options can be a significant clinical problem. New treatments are under development, and the majority of these new drugs focus on targeting a skewed immune response in AD...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29316557/editorial
#16
EDITORIAL
Gregor B E Jemec, Jürgen Lademann, Sandra Braun
No abstract text is available yet for this article.
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29316554/skin-infections-due-to-bacteria-in-solid-organ-transplant-recipients-a-review
#17
Muneeb Ilyas, Nishita Maganty, Zachary Ginsberg, Amit Sharma
Though there is an abundance of information on cutaneous malignancies in transplant recipients, cutaneous infections in solid organ transplant recipients (SOTRs) are underrepresented in the dermatological literature. Our paper provides a comprehensive review of bacterial cutaneous infections within the solid organ transplant population. Cutaneous bacterial infections may lead to significant morbidity and even mortality in this immunosuppressed population. Thus, it is to the benefit of both dermatologists and other transplant care providers to better understand and recognize the features of cutaneous bacterial infections in SOTRs...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29258098/the-magnitude-of-mtorc1-signalling-may-predict-the-response-to-isotretinoin-treatment-in-patients-with-hidradenitis-suppurativa
#18
Valerio De Vita, Bodo C Melnik
No abstract text is available yet for this article.
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29258093/th17-inhibitors-in-active-psoriatic-arthritis-a-systematic-review-and-meta-analysis-of-randomized-controlled-clinical-trials
#19
Girish S Naik, Wai K Ming, Itai M Magodoro, Babatunde Akinwunmi, Sara Dar, Henrik E Poulsen, Lars E Kristensen, Christina Ellervik
BACKGROUND: Several biologics targeting the Th17 pathway have been developed for the treatment of psoriatic arthritis (PsA), a disabling disease with moderate response and an increased incidence of serious infections to first-line biologics (TNF-α antagonists). Th17 inhibitors could replace TNF-α antagonists as first-line biologic agents. We determined the overall treatment effect of Th17 pathway inhibitors compared to placebo or active control on American College of Rheumatology (ACR) 20 response at week 12 (primary objective), risk of infections, discontinuation of treatment due to adverse events, and serious adverse events during the placebo-controlled period (12-24 weeks) in adults with active PsA in published randomized controlled trials...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29241216/melanoma-screening
#20
Karsten Juhl Jørgensen
No abstract text is available yet for this article.
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
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