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Dermatology: International Journal for Clinical and Investigative Dermatology

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https://www.readbyqxmd.com/read/30227428/impaired-skin-barrier-function-and-downregulated-expression-of-caspase-14-in-moderate-to-severe-chronic-hand-eczema
#1
Ben Wang, Ling-Ling Liu, Zuo-Tao Zhao, Ping Tu
AIM: To investigate whether the skin barrier function is impaired with regard to the pH value, water content, transepidermal water loss (TEWL), and the integrity of the stratum corneum, and whether the expression of caspase-14 is altered in moderate to severe chronic hand eczema (CHE). METHODS: Thirty patients with moderate to severe CHE treated at our institute and 30 healthy volunteers were included in this study. The pH value, water content, TEWL, and the integrity of the stratum corneum were measured in all subjects...
September 18, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/30205412/epidemiological-and-clinical-patterns-of-kaposi-sarcoma-a-16-year-retrospective-cross-sectional-study-from-yaound%C3%A3-cameroon
#2
Dahlia Noëlle Tounouga, Emmanuel Armand Kouotou, Jobert Richie Nansseu, Anne-Cécile Zoung-Kanyi Bissek
BACKGROUND: The burden of Kaposi sarcoma (KS) is increasing fast among HIV-infected populations, but the disease remains desperately underexplored in Cameroon, where the burden of HIV is high. METHODS: This is a retrospective cross-sectional study carried out over a period of 16 years (January 2001 to December 2016) at the HIV day care unit of the Central Hospital of Yaoundé, Cameroon. The diagnosis was based on clinical aspects and histological confirmation, and we used a preconstructed questionnaire for data collection through patients' electronic and physical files...
September 11, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/30205372/prevalence-of-phototherapy-in-the-age-of-biologics
#3
Piergiacomo Calzavara-Pinton, Arianna Zanca, Mariachiara Arisi, Maria Teresa Rossi, Cristina Zane, Marina Venturini, Bernhard Ortel
BACKGROUND: The prevalence of narrow-band ultraviolet B (NB-UVB) use in Europe for moderate and severe psoriasis is unknown, because national registries for psoriasis do not monitor this treatment. OBJECTIVES: To quantify the use of phototherapy, biologics or conventional treatments in psoriasis, in a setting where European Medicines Agency (EMA) eligibility criteria for biologics were strictly applied, and phototherapy was included among first-line treatments. METHODS: We followed a cohort of 1,090 patients who were referred to the only centre entitled to prescribe biologics and phototherapy during a 5-year period...
September 11, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/30199884/polymorphous-light-eruption-phototherapy-based-desensitization-versus-intramuscular-steroids-who-is-right-who-is-wrong
#4
Florence Libon, Arjen F Nikkels
No abstract text is available yet for this article.
September 10, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/30199871/cutaneous-arteriolosclerosis-is-not-specific-to-ischemic-hypertensive-leg-ulcers
#5
Jean-Benoît Monfort, Karine Cury, Philippe Moguelet, François Chasset, Claude Bachmeyer, Camille Francès, Annick Barbaud, Patricia Senet
BACKGROUND: The histological characteristic of hypertensive leg ulcers (HLU) is the presence of "arteriolosclerosis." The pertinence of performing a skin biopsy to diagnose HLU is questionable, as cutaneous arteriolosclerosis may be related to patient comorbidities. The objective here was to evaluate the frequency of arteriolosclerosis in skin leg biopsies performed in patients without ulcer and in control patients with HLU. METHODS: We performed a retrospective study between January 2013 and July 2014...
September 10, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/30176661/decreased-systemic-levels-of-endocan-1-and-cxcl16-in-psoriasis-are-restored-following-narrowband-uvb-treatment
#6
Gunnthorunn Sigurdardottir, Anna-Karin Ekman, Deepti Verma, Charlotta Enerbäck
BACKGROUND: In psoriasis, a common immune-mediated disease affecting 2-3% of the population worldwide, there is an increased prevalence of extracutaneous diseases including obesity, the metabolic syndrome, and cardiovascular disease. This is believed to be linked to systemic inflammation. In previous studies, we have explored various markers in plasma and serum to characterize the ongoing systemic inflammation in psoriasis patients compared to controls. We have identified several markers that were altered in psoriasis patients, but which all were unresponsive to narrowband UVB (NB-UVB) treatment...
September 3, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/30176655/tattoos-and-penalty-success-at-the-fifa-world-cup-2018
#7
LETTER
Simon M Müller, Samuel Hogg, Peter Itin
No abstract text is available yet for this article.
September 3, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/30149383/hurley-iii-hidradenitis-suppurativa-has-an-aggressive-disease-course
#8
LETTER
Annika M J D Vanlaerhoven, Christine B Ardon, Kelsey R van Straalen, Allard R J V Vossen, Errol P Prens, Hessel H van der Zee
No abstract text is available yet for this article.
August 27, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/30125890/prevalence-of-actinic-keratosis-in-patients-attending-general-practitioners-in-switzerland
#9
Piotr J Dziunycz, Elisabeth Schuller, Günther F L Hofbauer
BACKGROUND: Most of the data concerning the prevalence of actinic keratosis (AK) originate from the USA and Australia, and recently from Austria and Spain, but are based on populations in dermatology practices. Switzerland is the leading country with skin cancer incidence in Europe. AK prevalence among the Swiss population is therefore an important public health issue. OBJECTIVE: To assess the prevalence of AK in the outpatient Swiss population in general practice...
August 20, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/30121657/are-your-patients-satisfied-a-systematic-review-of-treatment-satisfaction-measures-in-psoriasis
#10
Nicole Salame, Lourdes M Perez-Chada, Sanminder Singh, Kristina Callis Duffin, Amit Garg, Alice B Gottlieb, John Latella, Joseph F Merola, April W Armstrong
Treatment satisfaction is paramount to the field of dermatology. Treatment dissatisfaction directly impacts patient outcomes and health care delivery. A critical need exists for standardized, validated treatment satisfaction measures in dermatology. Comprehensive evaluation of the performance of treatment satisfaction instruments used in psoriasis is lacking. We sought to critically appraise the literature on measurement properties of treatment satisfaction instruments used in psoriasis. We performed a systematic review to identify treatment satisfaction instruments used in psoriasis and corresponding studies on their measurement properties...
August 17, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/30114700/spontaneous-keloids-a-literature-review
#11
Abdulhadi Jfri, Ali Alajmi
BACKGROUND: Keloids are benign fibroproliferative tumors that extend beyond the original wound. Spontaneous keloids are those that result without a significant history of trauma. There are multiple reported cases in the literature. OBJECTIVE: This article provides a summary and review of the cases that have been reported with spontaneous keloids and organizes them according to their associated medical conditions. METHODS: A literature review was conducted using PubMed and MEDLINE that included all English published cases and case series from May 1955 to February 2018...
2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/30110681/characterization-and-outcomes-of-disease-progression-in-52-patients-treated-with-braf-v600-mek-inhibitors-for-advanced-melanoma
#12
Philippine Lucas, Serge Boulinguez, Vincent Sibaud, Loïc Mourey, Laurence Lamant, Carle Paul, Nicolas Meyer
BACKGROUND: Combined treatment with BRAF-V600 and MEK inhibitors has significantly improved progression-free and overall survival of patients with BRAF-mutated melanoma. Pattern of disease progression and outcomes in patients have not been fully characterized. METHODS: We conducted a single-center, retrospective, descriptive analysis of a cohort of 52 patients treated with BRAF-V600 + MEK inhibitors for advanced melanoma over a 12-month period. The aim of this study was to characterize disease progression, defined as metastatic pattern, disease kinetics, and response to subsequent therapies, in melanoma patients treated with BRAF-V600 + MEK inhibitors...
2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/30110673/association-between-atopic-dermatitis-and-the-metabolic-syndrome-a-systematic-review
#13
REVIEW
Zarqa Ali, Charlotte Suppli Ulrik, Tove Agner, Simon Francis Thomsen
Atopic dermatitis (AD) may be associated with the metabolic syndrome and by that carry an increased risk of cardio-vascular disease. Our objective was to provide an update on current knowledge of the association between AD and metabolic syndrome, including each component of the metabolic syndrome. A systematic literature review was performed to identify studies investigating the association between metabolic syndrome and AD from PubMed, Embase, and the Cochrane Library in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines...
2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/30092597/utility-of-horizontal-sections-of-scalp-biopsies-in-differentiating-between-androgenetic-alopecia-and-alopecia-areata
#14
Deepika Yadav, Sujay Khandpur, M Ramam, Manoj K Singh, Vinod K Sharma
BACKGROUND: Androgenetic alopecia (AGA) and alopecia areata (AA) are common causes of alopecia which can sometimes be difficult to differentiate clinically. Horizontal sections of scalp biopsies are used to study non-cicatricial alopecias due to the ability to perform both quantitative and morphometric analysis of hair follicles on them. METHODS: It was a prospective, cross-sectional study conducted to assess the utility of horizontal sections to differentiate between the alopecias...
2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/30086541/differences-in-rate-of-complete-excision-of-basal-cell-carcinoma-by-dermatologists-plastic-surgeons-and-general-practitioners-a-large-cross-sectional-study
#15
Kirtie Ramdas, Charlotte van Lee, Samuel Beck, Patrick Bindels, Vincent Noordhoek Hegt, Luba Pardo, Sarah Versnel, Tamar Nijsten, Renate van den Bos
BACKGROUND: Due to the increasing incidence of basal cell carcinoma (BCC) and rising health care costs, health care insurance companies seek ways to shift skin surgery for BCC from secondary to primary care. OBJECTIVES: To study the differences in complete excision of BCC by general practitioners (GPs), dermatologists, and plastic surgeons. METHODS: A retrospective cross-sectional study of pathology records of 2,986 standard excisions of primary BCCs performed by a GP, dermatologist, or plastic surgeon in the area of Southwest Netherlands between 2008 and 2014...
2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/30064128/large-nasal-defects-with-exposed-cartilage-the-folded-transposition-flap-as-an-innovative-alternative-to-the-paramedian-forehead-flap
#16
Kristina Schäfer, Christina Rudolph, Sebastian Cotofana, Matthias Goebeler, Gerhard Weyandt
BACKGROUND: Skin cancer removal surgery involving the tip or dorsum of the nose often results in large-sized defects with exposure of cartilage. In such cases, the paramedian forehead flap is a frequently used reconstruction technique; however, this method is complex and can result in a cosmetically unsatisfying outcome. OBJECTIVE: To describe the folded transposition flap as an aesthetically pleasing alternative to the paramedian forehead flap for large nasal defects with exposed cartilage...
2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/30041183/the-energy-density-and-treatment-times-are-the-main-factors-that-affect-the-efficacy-of-long-pulsed-1-064-nm-nd-yag-laser-treatment-for-onychomycosis-caused-by-trichophyton-rubrum
#17
Chao Liu, Ling Zhang, Hai-Yan Zeng, Hong Bei, Shi-Ping Chen, Yi-Xi Wu, Wen-Xia Luo, Qing Fang, Pin-Mei Liu
BACKGROUND: No optimal regimen exists for the LPNYL (long-pulsed 1,064-nm neodymium:yttrium-aluminum-garnet laser) for treating onychomycosis. OBJECTIVE: To establish an optimal LPNYL treatment regimen for onychomycosis caused by Trichophyton rubrum (OCTr). PATIENTS AND METHODS: First, 511 infected nails of 177 patients were treated using LPNYL with orthogonally designed regimens according to various energy densities, spot sizes, pulse widths, and treatment times...
2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/30032152/dermoscopy-of-cutaneous-lymphoproliferative-disorders-where-are-we-now
#18
REVIEW
Vincenzo Piccolo, Teresa Russo, Marina Agozzino, Paola Vitiello, Stefano Caccavale, Roberto Alfano, Giuseppe Argenziano
The prompt identification of cutaneous lymphoproliferative disorders (CLD) has always been a challenge in dermatological practice, due to the rarity of this group of diseases, the heterogeneity in clinical presentation, and plenty of variants described in the literature so far. The strict cooperation between dermatologist and pathologist is the key element for the correct diagnosis of CLD deriving from the perfect integration of clinical and histopathological features. In this complex context, dermoscopy could play an adjuvant role in the achievement of the diagnosis, as it fits itself as the third diagnostic tool in the paraphernalia of the dermatologist between the clinical and histopathological examination...
2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29972827/effects-of-initiation-time-of-glycemic-control-on-skin-collagen-recovery-in-streptozotocin-induced-diabetic-rats
#19
Yoorock Suh, Jungyoon Moon, Ji Young Yoon, Soo Woong Kim, Yu Sung Choi
BACKGROUND: Diabetes damages the collagen in the skin. No study has investigated the relationship between the treatment initiation time and the degree of collagen recovery. This study aimed to evaluate the effects of the initiation time of glycemic control on collagen recovery and to determine the basic molecules mediating the process. METHODS: Streptozotocin-induced diabetic rats were divided into five groups: normal controls (C), those with untreated diabetes (DM), and those with diabetes treated with daily insulin injections from 7 weeks (7W), 10 weeks (10W), and 13 weeks (13W) after diabetes induction...
2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29969769/is-human-sebum-the-source-of-skin-follicular-ultraviolet-induced-red-fluorescence-a-cellular-to-histological-study
#20
De-Tian Xu, Jian-Na Yan, Wei Liu, Xiao-Xiao Hou, Yan Zheng, Wei-Wei Jiang, Qiang Ju, Christos C Zouboulis, Xiu-Li Wang
BACKGROUND: The ultraviolet-induced red fluorescence (UVRF) from human skin follicles was suggested to be a result of Propionibacterium acnes and was used for the monitoring of acne. More recent studies suggested that the UVRF may be more related to sebum rather than to microorganisms. OBJECTIVE: To clarify whether human sebum or follicular microorganisms are the source of UVRF. METHODS: We examined the fluorescence of human-derived SZ95 sebocytes, human sebaceous glands, sebum extracted from the sebaceous glands, and bacteria isolated from human hair follicles under ultraviolet light...
2018: Dermatology: International Journal for Clinical and Investigative Dermatology
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