journal
MENU ▼
Read by QxMD icon Read
search

Developmental Dynamics: An Official Publication of the American Association of Anatomists

journal
https://www.readbyqxmd.com/read/29396915/p63-expression-plays-a-role-in-developmental-rate-embryo-size-and-local-morphogenesis
#1
Julia C Boughner, Matthijs C van Eede, Shoshana Spring, Lisa X Yu, Nasim Rostampour, R Mark Henkelman
BACKGROUND: The p63 gene is integral to the development of many body parts including limb, palate, teeth and urogenital tract. Loss of p63 expression may alter developmental rate, which is crucial to normal morphogenesis. To validate a novel, unbiased embryo phenotyping software tool, we tested whether delayed development contributes to the pathological phenotype of a p63 mouse mutant (p63-/- ). We quantified dysmorphology in p63-/- embryos and tested for universal growth delay relative to wild type (WT) embryos...
February 3, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29396887/a-staging-table-for-the-embryonic-development-of-the-brownbanded-bamboo-shark-chiloscyllium-punctatum
#2
Koh Onimaru, Fumio Motone, Itsuki Kiyatake, Kiyonori Nishida, Shigehiro Kuraku
BACKGROUND: Studying cartilaginous fishes (chondrichthyans) has helped us understand vertebrate evolution and diversity. However, resources such as genome sequences, embryos, and detailed staging tables are limited for species within this clade. To overcome these limitations, we have focused on a species, the brownbanded bamboo shark (Chiloscyllium punctatum), which is a relatively common aquarium species that lays eggs continuously throughout the year. In addition, because of its relatively small genome size, this species is promising for molecular studies...
February 3, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29396890/duplicated-foxa-genes-in-the-leech-helobdella-insights-into-the-evolution-of-direct-development-in-clitellate-annelids
#3
Dian-Han Kuo, Yu-Hsiang Hsiao
BACKGROUND: As an adaptation to the land, the clitellate annelid had reorganized its embryogenesis to develop "directly" without the ancestral planktonic larval stage. To study the evolution of gut development in the directly developing clitellates, we characterized the expression pattern of the conserved gut gene FoxA in the embryonic development of the leech. RESULTS: The leech has three FoxA paralogs. Hau-FoxA1 is first expressed in a subset of endoderm cells and then in the foregut and the midgut...
February 2, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29368411/dual-regulation-of-decorin-by-androgen-and-hedgehog-signaling-during-prostate-morphogenesis
#4
Monica Montano, Kenneth H Dinnon, Logan Jacobs, William Xiang, Renato V Iozzo, Wade Bushman
BACKGROUND: Prostate ductal branching morphogenesis involves a complex spatiotemporal regulation of cellular proliferation and remodeling of the extracellular matrix (ECM) around the developing ducts. Decorin (Dcn) is a small leucine-rich proteoglycan known to sequester several growth factors and to act as a tumor suppressor in prostate cancer. RESULTS: Dcn expression in the developing prostate paralleled branching morphogenesis and was dynamically regulated by androgen and Hedgehog (Hh) signaling...
January 25, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29330942/skeletal-development-in-the-heterocercal-caudal-fin-of-spotted-gar-lepisosteus-oculatus-and-other-lepisosteiformes
#5
Thomas Desvignes, Andrew Carey, Ingo Braasch, Trevor Enright, John H Postlethwait
BACKGROUND: The caudal fin of actinopterygians experienced substantial morphological changes during evolution. In basal actinopterygians, the caudal fin skeleton supports an asymmetrical heterocercal caudal fin, while most teleosts have a symmetrical homocercal caudal fin. The transition from the ancestral heterocercal form to the derived homocercal caudal fin remains poorly understood. Few developmental studies provide an understanding of derived and ancestral characters among basal actinopterygians...
January 13, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29330887/loss-of-vamp5-in-mice-results-in-duplication-of-the-ureter-and-insufficient-expansion-of-the-lung
#6
Maiko Ikezawa, Yuki Tajika, Hitoshi Ueno, Tohru Murakami, Naokazu Inoue, Hiroshi Yorifuji
BACKGROUND: VAMP5 is a member of the SNARE protein family, which regulate the docking and fusion of membrane vesicles within cells. Previously, we reported ubiquitous expression of VAMP5 proteins in various organs except the brain and small intestine. However, the precise roles of VAMP5 in each organ remain unclear. To explore the roles of VAMP5 in vivo, we generated VAMP5 knockout (KO) mice. RESULTS: VAMP5 KO mice showed low birth rate and low body weight. KO embryos grew normally in the uterus, and tended to die around birth...
January 13, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29318731/absence-of-the-drosophila-jump-muscle-actin-act79b-is-compensated-by-up-regulation-of-act88f
#7
Tracy E Dohn, Richard M Cripps
BACKGROUND: Actins are structural components of the cytoskeleton and muscle, and numerous actin isoforms are found in most organisms. However, many actin isoforms are expressed in distinct patterns allowing each actin to have a specialized function. Numerous studies have demonstrated that actin isoforms both can and cannot compensate for each other under specific circumstances. This allows for an ambiguity of whether isoforms are functionally distinct. RESULTS: In this study, we analyzed mutants of Drosophila Act79B, the predominant actin expressed in the adult jump muscle...
January 10, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29266590/rna-helicase-mov10-is-essential-for-gastrulation-and-cns-development
#8
Geena Skariah, Kimberly J Perry, Jenny Drnevich, Jonathan J Henry, Stephanie Ceman
BACKGROUND: Mov10 is an RNA helicase that modulates access of Argonaute 2 to microRNA recognition elements in mRNAs. We examined the role of Mov10 in Xenopus laevis development and show a critical role for Mov10 in gastrulation and in the development of the central nervous system. RESULTS: Knockdown of maternal Mov10 in Xenopus embryos using a translation blocking morpholino led to defects in gastrulation and the development of notochord and paraxial mesoderm, and a failure to neurulate...
December 21, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29247590/transient-phenotypic-changes-in-endothelial-cells-and-pericytes-in-neonatal-mouse-retina-following-short-term-blockade-of-vascular-endothelial-growth-factor-receptors
#9
Akane Morita, Asami Mori, Shiho Arima, Kenji Sakamoto, Tohru Nagamitsu, Kunio Ishii, Tsutomu Nakahara
BACKGROUND: A short-term interruption of vascular development causes structural abnormalities in retinal vasculature. However, the detailed changes in vascular components (endothelial cells, pericytes, and basement membranes) remain to be fully determined. The present study aimed to provide a detailed description of morphological changes in vascular components following a short-term interruption of retinal vascular development in mice. RESULTS: Two-day treatment of neonatal mice with the vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor KRN633 (10 mg/kg, subcutaneously) on postnatal day (P)0 and P1 (P0/1) and P4 and P5 (P4/5) induced different degrees and patterns of impairment of retinal vascular development...
December 16, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29243319/zebrafish-rfx4-controls-dorsal-and-ventral-midline-formation-in-the-neural-tube
#10
Irina Sedykh, Abigail N Keller, Baul Yoon, Laura Roberson, Oleg V Moskvin, Yevgenya Grinblat
BACKGROUND: Rfx winged-helix transcription factors, best known as key regulators of core ciliogenesis, also play ciliogenesis-independent roles during neural development. Mammalian Rfx4 controls neural tube morphogenesis via both mechanisms. RESULTS: We set out to identify conserved aspects of rfx4 gene function during vertebrate development and to establish a new genetic model in which to analyze these mechanisms further. To this end, we have generated frame-shift alleles in the zebrafish rfx4 locus using CRISPR/Cas9 mutagenesis...
December 15, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29226547/avian-embryonic-coronary-arterio-venous-pattering-involves-the-contribution-of-different-endothelial-and-endocardial-cell-populations
#11
Paul Palmquist-Gomes, Juan Antonio Guadix, José M Pérez-Pomares
BACKGROUND: Coronary vasculature irrigates the myocardium and is crucial to late embryonic and adult heart function. Despite the developmental significance and clinical relevance of these blood vessels, the embryonic origin and the cellular and molecular mechanisms that regulate coronary arterio-venous patterning are not known in detail. In this study, we have used the avian embryo to dissect the ontogenetic origin and morphogenesis of coronary vasculature. RESULTS: We show that sinus venosus endocardial sprouts and proepicardial angioblasts pioneer coronary vascular formation, invading the developing heart simultaneously...
December 11, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29226543/maternal-immune-activation-in-neurodevelopmental-disorders
#12
REVIEW
Cynthia M Solek, Nasr Farooqi, Myriam Verly, Tony K Lim, Edward S Ruthazer
Converging lines of evidence from basic science and clinical studies suggest a relationship between maternal immune activation (MIA) and neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia. The mechanisms through which MIA increases the risk of neurodevelopmental disorders have become a subject of intensive research. This review aims to describe how dysregulation of microglial function and immune mechanisms may link MIA and neurodevelopmental pathologies. We also summarize the current evidence in animal models of MIA...
December 11, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29226492/molecular-mechanisms-underlying-monosynaptic-sensory-motor-circuit-development-in-the-spinal-cord
#13
REVIEW
Fumiyasu Imai, Yutaka Yoshida
Motor behaviors are precisely controlled by the integration of sensory and motor systems in the central nervous system (CNS). Proprioceptive sensory neurons, key components of the sensory system, are located in the dorsal root ganglia and project axons both centrally to the spinal cord and peripherally to muscles and tendons, communicating peripheral information about the body to the CNS. Changes in muscle length detected by muscle spindles, and tension variations in tendons conveyed by golgi tendon organs, are communicated to the CNS through group Ia/II, and Ib proprioceptive sensory afferents, respectively...
December 11, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29226467/axon-guidance-pathways-and-the-control-of-gene-expression
#14
REVIEW
Samantha A Russell, Greg J Bashaw
Axons need to be properly guided to their targets to form synaptic connections, and this requires interactions between highly conserved extracellular and transmembrane ligands and their cell surface receptors. The majority of studies on axon guidance signaling pathways have focused on the role of these pathways in rearranging the local cytoskeleton and plasma membrane in growth cones and axons. However, a smaller body of work has demonstrated that axon guidance signaling pathways also control gene expression via local translation and transcription...
December 11, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29171103/adult-functions-for-the-drosophila-dhr78-nuclear-receptor
#15
Stefanie Marxreiter, Carl S Thummel
BACKGROUND: The Testicular Receptors 2 and 4 (TR2, TR4) comprise a small subfamily of orphan nuclear receptors. Genetic studies in mouse models have identified roles for TR4 in developmental progression, fertility, brain development, and metabolism, as well as genetic redundancy with TR2. Here we study the adult functions of the single Drosophila member of this subfamily, DHR78, with the goal of defining its ancestral functions in the absence of genetic redundancy. RESULTS: We show that DHR78 mutants have a shortened lifespan, reduced motility, and mated DHR78 mutant females display a reduced feeding rate...
November 24, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29446197/epithelial-mesenchymal-transition-and-plasticity-in-the-developmental-basis-of-cancer-and-fibrosis
#16
EDITORIAL
Raymond B Runyan, Pierre Savagner
No abstract text is available yet for this article.
March 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29265589/developmental-biology-more-dynamic-than-ever
#17
EDITORIAL
Paul A Trainor
No abstract text is available yet for this article.
January 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29144604/transitions
#18
EDITORIAL
Parker B Antin
No abstract text is available yet for this article.
December 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28791750/histone-deacetylase-1-and-2-are-essential-for-murine-neural-crest-proliferation-pharyngeal-arch-development-and-craniofacial-morphogenesis
#19
Zachary J Milstone, Grace Lawson, Chinmay M Trivedi
BACKGROUND: Craniofacial anomalies involve defective pharyngeal arch development and neural crest function. Copy number variation at 1p35, containing histone deacetylase 1 (Hdac1), or 6q21-22, containing Hdac2, are implicated in patients with craniofacial defects, suggesting an important role in guiding neural crest development. However, the roles of Hdac1 and Hdac2 within neural crest cells remain unknown. RESULTS: The neural crest and its derivatives express both Hdac1 and Hdac2 during early murine development...
December 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28710815/lacrimal-gland-development-from-signaling-interactions-to-regenerative-medicine
#20
REVIEW
Ankur Garg, Xin Zhang
The lacrimal gland plays a pivotal role in keeping the ocular surface lubricated, and protecting it from environmental exposure and insult. Dysfunction of the lacrimal gland results in deficiency of the aqueous component of the tear film, which can cause dryness of the ocular surface, also known as the aqueous-deficient dry eye disease. Left untreated, this disease can lead to significant morbidity, including frequent eye infections, corneal ulcerations, and vision loss. Current therapies do not treat the underlying deficiency of the lacrimal gland, but merely provide symptomatic relief...
December 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
journal
journal
30931
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"