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Developmental Dynamics: An Official Publication of the American Association of Anatomists

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https://www.readbyqxmd.com/read/29024245/hace1-influences-zebrafish-cardiac-development-via-ros-dependent-mechanisms
#1
Babak Razaghi, Shelby L Steele, Sergey V Prykhozhij, Matthew R Stoyek, Jessica A Hill, Matthew D Cooper, Lindsay McDonald, William Lin, Mads Daugaard, Nicolas Crapoulet, Simi Chacko, Stephen Lewis, Ian C Scott, Poul H B Sorensen, Jason N Berman
BACKGROUND: In this study we reveal a previously undescribed role of the HACE1 (HECT domain and Ankyrin repeat Containing E3 ubiquitin-protein ligase 1) tumor suppressor protein in normal vertebrate heart development using the zebrafish (Danio rerio) model. We examined the link between the cardiac phenotypes associated with hace1 loss of function to the expression of the Rho small family GTPase, rac1, which is a known target of HACE1 and promotes ROS production via its interaction with NADPH oxidase holoenzymes...
October 11, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28980356/remapping-the-microtubule-landscape-how-phosphorylation-dictates-the-activities-of-microtubule-associated-proteins
#2
REVIEW
Amrita Ramkumar, Brigette Y Jong, Kassandra M Ori-McKenney
Classical microtubule associated proteins (MAPs) were originally identified based on their co-purification with microtubules assembled from mammalian brain lysate. They have since been found to perform a range of functions involved in regulating the dynamics of the microtubule cytoskeleton. Most of these MAPs play integral roles in microtubule organization during neuronal development, microtubule remodeling during neuronal activity, and microtubule stabilization during neuronal maintenance. As a result, mutations in MAPs contribute to neurodevelopmental disorders, psychiatric conditions, and neurodegenerative diseases...
October 4, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28975691/gut-feelings-studying-enteric-nervous-system-development-function-and-disease-in-the-zebrafish-model-system
#3
REVIEW
Julia Ganz
The enteric nervous system (ENS) is the largest part of the peripheral nervous system and is entirely neural crest derived. It provides the intrinsic innervation of the gut controlling different aspects of gut function, such as motility. In this review, we will discuss key points of zebrafish ENS development, genes and signaling pathways regulating ENS development as well as contributions of the zebrafish model system to better understand ENS disorders. During their migration, enteric progenitor cells display a gradient of developmental states based on their proliferative and migratory characteristics and show spatio-temporal heterogeneity based on gene expression patterns...
October 4, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28975680/yolk-sac-erythromyeloid-progenitors-expressing-gain-of-function-ptpn11-have-functional-features-of-jmml-but-are-not-sufficient-to-cause-disease-in-mice
#4
Stefan P Tarnawsky, Momoko Yoshimoto, Lisa Deng, Rebecca J Chan, Mervin C Yoder
BACKGROUND: Accumulating evidence suggests the origin of Juvenile Myelomonocytic Leukemia (JMML) is closely associated with fetal development. Nevertheless, the contribution of embryonic progenitors to JMML pathogenesis remains unexplored. We hypothesized that expression of JMML-initiating PTPN11 mutations in HSC-independent yolk sac erythromyeloid progenitors (YS EMPs) would result in a mouse model of pediatric myeloproliferative neoplasm (MPN). RESULTS: E9.5 YS EMPs from VavCre+;PTPN11(D61Y) embryos demonstrated growth hypersensitivity to GM-CSF and hyperactive RAS-ERK signaling...
October 4, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28960588/prospects-for-new-lung-cancer-treatments-that-target-emt-signaling
#5
REVIEW
Yuji Otsuki, Hideyuki Saya, Yoshimi Arima
Lung cancer is the most common cancer worldwide. Treatment options for lung cancer include surgery, radiation therapy, chemotherapy, molecularly targeted therapy including epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK) inhibitors, and immunotherapy. These treatments can be administered alone or in combination. Despite therapeutic advances, however, lung cancer remains the leading cause of cancer death. Recent studies have indicated that epithelial-mesenchymal transition (EMT) is associated with malignancy in various types of cancer, and activation of EMT signaling in cancer cells is widely considered to contribute to metastasis, recurrence, or therapeutic resistance...
September 27, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28940676/asymmetric-development-of-the-nervous-system
#6
REVIEW
Amel Alqadah, Yi-Wen Hsieh, Zachery D Morrissey, Chiou-Fen Chuang
The human nervous system consists of seemingly symmetric left and right halves. However, closer observation of the brain reveals anatomical and functional lateralization. Defects in brain asymmetry correlate with several neurological disorders, yet our understanding of the mechanisms used to establish lateralization in the human central nervous system is extremely limited. Here, we review left-right asymmetries within the nervous system of humans and several model organisms, including rodents, zebrafish, chickens, Xenopus, Drosophila, and the nematode Caenorhabditis elegans...
September 23, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28929539/refuting-the-hypothesis-that-semaphorin-3f-neuropilin-2-exclude-blood-vessels-from-the-cap-mesenchyme-in-the-developing-kidney
#7
David A D Munro, Peter Hohenstein, Thomas M Coate, Jamie A Davies
BACKGROUND: During murine kidney development, new cortical blood vessels form and pattern in cycles that coincide with cycles of collecting duct branching and the accompanying splitting of the cap mesenchyme (nephron progenitor cell populations that 'cap' collecting duct ends). At no point in the patterning cycle do blood vessels enter the cap mesenchyme. We hypothesised that the exclusion of blood vessels from the cap mesenchyme may be controlled, at least in part, by an anti-angiogenic signal expressed by the cap mesenchyme cells...
September 20, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28891223/promoter-architecture-and-transcriptional-regulation-of-musculoskeletal-embryonic-nuclear-protein-1b-mustn1b-gene-in-zebrafish
#8
P Suarez-Bregua, C J Chien, M Megias, S D Du, J Rotllant
BACKGROUND: Mustn1 is a specific musculoskeletal protein that plays a critical role in myogenesis and chondrogenesis in vertebrates. Whole-mount in situ hybridization revealed that mustn1b mRNAs are specifically expressed in skeletal and cardiac muscles in zebrafish embryos. However, the precise function and the regulatory elements required for its muscle-specific expression are largely unknown. RESULTS: The purpose of this study was to explore and uncover the target genomic regions that regulate mustn1b gene expression by in-vivo functional characterization of the mustn1b promoter...
September 11, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28891150/endothelial-to-mesenchymal-transition-in-cardiovascular-diseases-developmental-signalling-pathways-gone-awry
#9
REVIEW
Gonzalo Sánchez-Duffhues, Amaya García de Vinuesa, Peter Ten Dijke
The process named endothelial-to-mesenchymal transition (EndMT) was observed for the first time during the development of the chicken embryo several decades ago. Interestingly, accumulating evidence suggests that EndMT plays a critical role in the onset and progression of a multiple postnatal cardiovascular diseases. EndMT is controlled by a set of developmental signalling pathways, very similar to the process of epithelial-to-mesenchymal transition (EMT), which determine the activity of a number of EndMT transcriptional effectors...
September 11, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28891097/ventral-neural-patterning-in-the-absence-of-a-shh-activity-gradient-from-the-floorplate
#10
Angelo Iulianella, Daisuke Sakai, Hiroshi Kurosaka, Paul Trainor
BACKGROUND: Vertebrate spinal cord development requires Sonic Hedgehog (Shh) signaling from the floorplate and notochord, where it is thought to act in concentration dependent manner to pattern distinct cell identities along the ventral-to-dorsal axis. While in vitro experiments demonstrate naïve neural tissues are sensitive to small changes in Shh levels, genetic studies illustrate that some degree of ventral patterning can occur despite significant perturbations in Shh signaling. Consequently, the mechanistic relationship between Shh morphogen levels and acquisition of distinct cell identities remains unclear...
September 11, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28884516/removing-vessel-constriction-on-the-embryonic-heart-results-in-changes-in-valve-gene-expression-morphology-and-hemodynamics
#11
Vinal Menon, John Eberth, Lorain Junor, Alexander J Potts, Marwa Belhaj, Donald J DiPette, Michael Jenkins, Jay D Potts
BACKGROUND: The formation of healthy heart valves throughout embryonic development is dependent on both genetic and epigenetic factors. Hemodynamic stimuli are important epigenetic regulators of valvulogenesis, but the resultant molecular pathways that control valve development are poorly understood. Here, we describe how the heart and valves recover from the removal of a partial constriction (banding) of the OFT/ventricle junction (OVJ) that temporarily alters blood flow velocity through the embryonic chicken heart (HH stage 16/17)...
September 7, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28865166/asymmetries-in-leaf-branch-are-associated-with-differential-speeds-along-growth-axes-a-theoretical-prediction
#12
Akiko Nakamasu, Nobuhiko J Suematsu, Seisuke Kimura
Morphogenesis, when accompanied by continuous growth, requires stable positional information to create a balanced shape in an organism. Evenly spaced branches are examples of such morphogenesis. Previously, we created a model that showed when a one-dimensional ring (a boundary of a two-dimensional field) was periodically deformed based on a stable, doubled iterative pattern during expansion; a nested, regularly spaced, symmetrically branched structure was generated. The characteristic divaricating pattern is common in the leaves of many plant species; however, the divarication symmetry was often broken...
September 2, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28857338/single-nucleotide-editing-without-dna-cleavage-using-crispr-cas9-deaminase-in-the-sea-urchin-embryo
#13
Saba Shevidi, Alicia Uchida, Natalie Schudrowitz, Gary M Wessel, Mamiko Yajima
BACKGROUND: A single base pair mutation in the genome can result in many congenital disorders in humans. The recent gene editing approach using CRISPR/Cas9 has rapidly become a powerful tool to replicate or repair such mutations in the genome. These approaches rely on cleaving DNA, while presenting unexpected risks. RESULTS: In this study, we demonstrate a modified CRISPR/Cas9 system fused to Cytosine DeAminase (Cas9-DA), which induces a single nucleotide conversion in the genome...
August 31, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28856763/the-fly-eye-through-the-looking-glass
#14
REVIEW
Justin P Kumar
The developing eye-antennal disc of Drosophila melanogaster has been studied for more than a century and it has been used as a model system to study diverse processes such as tissue specification, organ growth, programmed cell death, compartment boundaries, pattern formation, cell fate specification, and planar cell polarity. The findings that have come out of these studies have informed our understanding of basic developmental processes as well as human disease. For example, the isolation of a white-eyed fly ultimately led to a greater appreciation of the role that sex chromosomes play in development, sex determination, and sex linked genetic disorders...
August 30, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28856758/the-gonadal-soma-controls-ovarian-follicle-proliferation-through-gsdf-in-zebrafish
#15
Yi-Lin Yan, Thomas Desvignes, Ruth BreMiller, Catherine Wilson, Danielle Dillon, Samantha High, Bruce Draper, Charles Loren Buck, John Postlethwait
BACKGROUND: Aberrant signaling between germ cells and somatic cells can lead to reproductive disease and depends on diffusible signals, including TGFB-family proteins. The TGFB-family protein Gsdf (gonadal soma derived factor) controls sex determination in some fish and is a candidate for mediating germ cell/soma signaling. RESULTS: Zebrafish expressed gsdf in somatic cells of bipotential gonads and expression continued in ovarian granulosa cells and testicular Sertoli cells...
August 30, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28850772/-mesenchymal-stromal-cell-engagement-in-cancer-cell-epithelial-to-mesenchymal-transition
#16
REVIEW
Drenka Trivanović, Jelena Krstić, Aleksandra Jauković, Diana Bugarski, Juan F Santibanez
Due to coexistence of stromal and epithelial tumor cells, their dynamic interactions have been widely recognized as significant cellular components to the tumor tissue integrity. Initiation and outcome of epithelial to mesenchymal transition (EMT) in tumor cells are dependent on their interaction with adjacent or recruited mesenchymal stromal cells (MSCs). A plethora of mechanisms are involved in MSCs-controlled employment of the developmental processes of EMT that contribute to loss of epithelial cell phenotype and acquisition of stemness, invasiveness and chemoresistance of tumor cells...
August 29, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28850769/expression-of-genes-and-proteins-of-the-pax-six-eya-dach-network-in-the-metamorphic-sea-urchin-insights-into-development-of-the-enigmatic-echinoderm-body-plan-and-sensory-structures
#17
Maria Byrne, Demian Koop, Valerie B Morris, Juanita Chui, Gregory A Wray, Paula Cisternas
BACKGROUND: Photoreception-associated genes of the Pax-Six-Eya-Dach network (PSEDN) are deployed for many roles in addition to photoreception development. In this first study of PSEDN genes during development of the pentameral body in sea urchins, we investigated their spatial expression in Heliocidaris erythrogramma. RESULTS: Expression of PSEDN genes in the hydrocoele of early (Dach, Eya, Six1/2) and/or late (Pax6, Six3/6) larvae, and the five hydrocoele lobes, the first morphological expression of pentamery, supports a role in body plan development...
August 29, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28850768/annual-killifish-adaptations-to-ephemeral-environments-diapause-i-in-two-austrolebias-species
#18
María José Arezo, Nicolás G Papa, Nibia Berois, Graciela Clivio, Jimena Montagne, Soledad De la Piedra
BACKGROUND: Many organisms are able to survive in extreme environments by entering a state of dormancy. In dormancy, vital activities are reduced until environmental conditions are compatible with active life. Annual killifishes show a special developmental pattern characterized by a phase of dispersion-reaggregation of the blastomeres that separates epiboly from organogenesis, and the capability to enter dormancy in diapause. High tolerance to environmental stress confers annual killifish embryos the condition of extremophiles...
August 29, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28850761/zebrafish-sin3b-mutants-are-viable-but-have-size-skeletal-and-locomotor-defects
#19
Cara E Moravec, Hakeem Yousef, Brian A Kinney, Ryan Salerno-Eichenholz, Camillia Monestime, Benjamin L Martin, Howard I Sirotkin
BACKGROUND: The transcriptional co-repressor Sin3 is highly conserved from yeast to vertebrates and has multiple roles controlling cell fate, cell cycle progression, and senescence programming. Sin3 proteins recruit HDACs and other chromatin modifying factors to specific loci through interactions with transcription factors including Myc, Rest, p53 and E2F. Most vertebrates have two Sin3 family members (sin3a and sin3b), but zebrafish have a second sin3a paralogue. In mice, sin3a and sin3b are essential for embryonic development...
August 29, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28850760/microrna-induced-silencing-in-epilepsy-opportunities-and-challenges-for-clinical-application
#20
REVIEW
Durgesh Tiwari, Katrina Peariso, Christina Gross
MicroRNAs are master regulators of gene expression. Single microRNAs influence multiple proteins within diverse molecular pathways and networks. Therefore, changes in levels or activity of microRNAs can have profound effects on cellular function. This makes dysregulated microRNA-induced silencing an attractive potential disease mechanism in complex disorders like epilepsy, where numerous cellular pathways and processes are affected simultaneously. Indeed, several years of research in rodent models have provided strong evidence that acute or recurrent seizures change microRNA expression and function...
August 29, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
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