journal
MENU ▼
Read by QxMD icon Read
search

Developmental Dynamics: An Official Publication of the American Association of Anatomists

journal
https://www.readbyqxmd.com/read/30450697/craniofacial-skeleton-of-mexican-tetra-astyanax-mexicanus-as-a-bone-disease-model
#1
REVIEW
Devi Sewvandini Atukorala Atukorallaya, Vikram Bhatia, Ravindra Ratnayake
A small fresh water fish, the Mexican tetra (Astyanax mexicanus) is a novel animal model in evolutionary developmental biology. The existence of morphologically distinct surface and cave morphs of this species allows simultaneous comparative analysis of phenotypic changes at different life stages. The cavefish harbours many favourable constructive traits (i.e. large jaws with an increased number of teeth, neuromast cells, enlarged olfactory pits and excess storage of adipose tissues) and regressive traits (i...
November 19, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/30444282/special-issue-on-stem-cell-and-tissue-engineering-in-development-disease-and-repair
#2
EDITORIAL
Aleksandr Shcheglovitov, Mahendra Rao, Andrew Yoo
No abstract text is available yet for this article.
November 16, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/30444278/developmental-roles-of-microglia-a-window-into-mechanisms-of-disease
#3
REVIEW
Sarah R Anderson, Monica L Vetter
Microglia are engineers of the CNS both in health and disease. In addition to the canonical immunological roles of clearing damaging entities and limiting the spread of toxicity and death, microglia remodel the CNS throughout life. While they have been extensively studied in disease and injury, due to their highly variable functions, their precise role in these contexts still remains uncertain. Over the last decade we have greatly expanded our understanding of microglial function, including their essential homeostatic roles during development...
November 16, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/30444277/pouc-regulates-expression-of-bmp4-during-atrioventricular-canal-formation-in-zebrafish
#4
Minoti Bhakta, Mahesh S Padanad, John P Harris, Christina Lubczyk, James F Amatruda, Nikhil V Munshi
BACKGROUND: Many human gene mutations have been linked to congenital heart disease (CHD), yet CHD remains a major health issue worldwide due in part to an incomplete understanding of the molecular basis for cardiac malformation. RESULTS: Here we identify the orthologous mouse Pou6f1 and zebrafish pouC as POU homeodomain transcription factors enriched in the developing heart. We find that pouC is a multi-functional transcriptional regulator containing separable activation, repression, protein-protein interaction, and DNA binding domains...
November 16, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/30324766/derivation-of-specific-neural-populations-from-pluripotent-cells-for-understanding-and-treatment-of-spinal-cord-injury
#5
REVIEW
Nicholas White, Shelly Sakiyama-Elbert
Due to the nature of the biological response to traumatic spinal cord injury, there are very limited therapeutic options available to patients. Recent advances in cell transplantation have demonstrated the therapeutic potential of transplanting supportive cell types following spinal cord injury. In particular, pluripotent stem cell derived neural cells are of interest for the future investigation. Use of pluripotent stem cells as the source allows many cell types to be produced from a population that can be expanded in vitro...
October 15, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/30303578/epithelial-mesenchymal-transition-and-cancer-stem-cells-at-the-crossroads-of-differentiation-and-dedifferentiation
#6
REVIEW
H Wang, J J Unternaehrer
In this review, we explore the connections between epithelial-mesenchymal transition (EMT) and differentiation status. EMTs in development have been described as differentiation events, while in most cases EMTs in cancer have been depicted as dedifferentiation events. We will briefly summarize both embryo development and cancer progression with regard to the involvement of EMT and cell differentiation status. We further present the studies that provide evidence that EMT results in both differentiation and dedifferentiation...
October 10, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/30291668/tissue-regeneration-enhancer-elements-a-way-to-unlock-endogenous-healing-power
#7
KaHoua Yang, Junsu Kang
Regenerative capacity is widespread throughout almost all animal phyla. However, the distribution pattern remains incompletely understood. Various examples show that very closely related species display different regenerative capacities. Why and how have diverse regenerative capacities evolved across species? One prevailing thought in the field of regeneration is that most regeneration-associated factors are evolutionarily conserved, suggesting the existence of an innate tissue regeneration ability in all species...
October 5, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/30269386/comparative-analysis-of-cul5-and-rbx2-expression-in-the-developing-and-adult-murine-brain-and-their-essentiality-during-mouse-embryogenesis
#8
Keiko Hino, Sergi Simó, Jonathan A Cooper
BACKGROUND: The E3 Cullin 5-RING ubiquitin ligase (CRL5) is a multiprotein complex that has recently been highlighted as a major regulator of central nervous system development. Cullin 5 (Cul5) and the RING finger protein Rbx2 are two CRL5 core components required for CRL5 function in the brain, but their full expression patterns and developmental functions have not been described in detail. RESULTS: Using a gene-trap mouse model for Cul5 and a knock-in-knockout mouse model for Rbx2, we show that lack of Cul5, but not Rbx2, disrupts blastocyst formation...
September 30, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/30265422/double-electroporation-in-two-adjacent-tissues-in-chicken-embryos
#9
Margarethe Draga, Felicitas Pröls, Martin Scaal
In ovo electroporation is a well established method to introduce transgenes into a number of tissues in chicken embryos, e.g., neural tissue, limb mesenchyme, and somites. This method has been widely used to investigate cell lineage, cell morphology, and molecular pathways by localized expression of fluorescent reporter constructs. Furthermore gain- and loss-of-function experiments can be performed by electroporating transgenes or gene-silencing constructs. We have developed a new technique to electroporate tissues positioned opposite to each other with different plasmids using an electroporation chamber...
September 28, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/30251381/maldevelopment-of-the-submandibular-gland-in-a-mouse-model-of-apert-syndrome
#10
Kojiro Yamaji, Jumpei Morita, Tsukasa Watanabe, Kaori Gunjigake, Mitsushiro Nakatomi, Momotoshi Shiga, Kentaro Ono, Keiji Moriyama, Tatsuo Kawamoto
BACKGROUND: Apert syndrome is characterized by craniosynostosis and bony syndactyly of the hands and feet. The cause of Apert syndrome is a single nucleotide substitution mutation (S252W or P253R) in fibroblast growth factor receptor 2 (FGFR2). Clinical experience suggests increased production of saliva by Apert syndrome patients, but this has not been formally investigated. FGFR2 signaling is known to regulate branching morphogenesis of the submandibular glands (SMGs). With the Apert syndrome mouse model (Ap mouse), we investigated the role of FGFR2 in SMGs and analyzed the SMG pathology of Apert syndrome...
September 25, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/30242792/retinal-ganglion-cell-replacement-current-status-and-challenges-ahead
#11
Adam M Miltner, Anna La Torre
The neurons of the retina can be affected by a wide variety of inherited or environmental degenerations that can lead to vision loss and even blindness. Retinal ganglion cell (RGC) degeneration is the hallmark of glaucoma and other optic neuropathies that affect millions of people worldwide. Numerous strategies are being trialed to replace lost neurons in different degeneration models, and in recent years, stem cell technologies have opened promising avenues to obtain donor cells for retinal repair. Stem cell-based transplantation has been most frequently used for the replacement of rod photoreceptors, but the same tools could potentially be used for other retinal cell types, including RGCs...
September 21, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/30394653/anteroposterior-molecular-registries-in-ectoderm-of-the-echinus-rudiment
#12
Shinya Adachi, Iyo Niimi, Yui Sakai, Fuminori Sato, Takuya Minokawa, Makoto Urata, Atsuko Sehara-Fujisawa, Isao Kobayashi, Masaaki Yamaguchi
BACKGROUND: Echinoderms and hemichordates are sister taxa that both have larvae with tripartite coeloms. Hemichordates inherit the coelom plan and ectoderm from larvae, whereas echinoderms form the adult rudiment comprising rearranged coeloms and a vestibule that then develops into adult oral ectoderm. Molecular networks that control patterns of the ectoderm and the central nervous system along the anteroposterior (AP) axis are highly conserved between hemichordates and chordates, respectively...
December 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/30376688/foxc2-is-required-for-proper-cardiac-neural-crest-cell-migration-outflow-tract-septation-and-ventricle-expansion
#13
Kimberly E Inman, Carlo Donato Caiaffa, Kristin R Melton, Lisa L Sandell, Annita Achilleos, Tsutomu Kume, Paul A Trainor
BACKGROUND: Proper development of the great vessels of the heart and septation of the cardiac outflow tract requires cardiac neural crest cells. These cells give rise to the parasympathetic cardiac ganglia, the smooth muscle layer of the great vessels, some cardiomyocytes, and the conotruncal cushions and aorticopulmonary septum of the outflow tract. Ablation of cardiac neural crest cells results in defective patterning of each of these structures. Previous studies have shown that targeted deletion of the forkhead transcription factor C2 (Foxc2), results in cardiac phenotypes similar to that derived from cardiac neural crest cell ablation...
December 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/30358936/ppar%C3%AE-deficiency-inhibits-the-proliferation-of-neuronal-and-glial-precursors-in-the-zebrafish-central-nervous-system
#14
Yen-Che Hsieh, Ming-Chang Chiang, Yin-Cheng Huang, Tu-Hsueh Yeh, Hung-Yu Shih, Han-Fang Liu, Hao-Yuan Chen, Chien-Ping Wang, Yi-Chuan Cheng
BACKGROUND: Many molecules and signaling pathways involved in neural development play a role in neurodegenerative diseases and brain tumor progression. Peroxisome proliferator-activated receptor (PPAR) proteins regulate the differentiation of tissues and the progression of many diseases. However, the role of these proteins in neural development is unclear. RESULTS: We examined the function of Pparα in the neural development of zebrafish. Two duplicate paralogs for mammalian PPARA/Ppara, namely pparaa and pparab, are present in the zebrafish genome...
December 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/30358924/newts-can-normalize-duplicated-proximal-distal-disorder-during-limb-regeneration
#15
Kazuki Koriyama, Risa Sakagami, Ayumi Myouga, Toshinori Hayashi, Takashi Takeuchi
BACKGROUND: Urodele animals can regenerate their limbs from the blastemas. The previous results of grafting proximal blastemas to distal limb levels (P to D transplantation) led to serial duplication of limb segments. However, it is unknown whether grafting to any distal levels in P to D transplantation causes serial duplication. In other words, it is unknown whether or not newt limbs can normalize such a kind of duplicated type of positional disorder in the proximal-distal axis. Therefore, we grafted the most proximal blastemas to various distal levels of the proximal-distal axis using newts (Pleurodeles waltl)...
December 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/30325085/myostatin-promotes-the-epithelial-to-mesenchymal-transition-of-the-dermomyotome-during-somitogenesis
#16
Yuchang Zhou, Yong Zhang, Dahai Zhu
BACKGROUND: Myostatin (MSTN), a member of the transforming growth factor-β (TGF-β) superfamily, has been implicated in the negative regulation of skeletal myogenesis. However, the molecular mechanism through which MSTN regulates early embryonic myogenesis is not well understood. RESULTS: We demonstrate that MSTN regulates early embryonic myogenesis by promoting the epithelial-to-mesenchymal transition (EMT) of the dermomyotome during somitogenesis in chicks. We show that the MSTN gene is first expressed at the center of the dermomyotome...
December 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/30325084/characterization-of-cis-regulatory-elements-for-fgf10-expression-in-the-chick-embryo
#17
Hiroko Kawakami, Austin Johnson, Yu Fujita, Avery Swearer, Naoyuki Wada, Yasuhiko Kawakami
BACKGROUND: Fgf10 is expressed in various tissues and organs, such as the limb bud, heart, inner ear, and head mesenchyme. Previous studies identified Fgf10 enhancers for the inner ear and heart. However, Fgf10 enhancers for other tissues have not been identified. RESULTS: By using primary culture chick embryo lateral plate mesoderm cells, we compared activities of deletion constructs of the Fgf10 promoter region, cloned into a promoter-less luciferase reporter vector...
December 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/30311321/identification-of-retinal-homeobox-rax-gene-dependent-genes-by-a-microarray-approach-the-dna-endoglycosylase-neil3-is-a-major-downstream-component-of-the-rax-genetic-pathway
#18
Yi Pan, Lisa E Kelly, Heithem M El-Hodiri
BACKGROUND: The retinal homeobox (rx/rax) gene is a transcription factor expressed in the developing eye field that is necessary for normal eye development. rax is necessary for retinal specification and stem cell development. The genetic program of early retinal development, including rax expression, can be induced in naïve ectoderm by activation of insulin-like growth factor (IGF) signaling. We have undertaken a microarray-based approach to identify rax-dependent IGF-induced genes...
November 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/30295986/identification-of-novel-gata3-distal-enhancers-active-in-mouse-embryonic-lens
#19
Elena Martynova, Maxime Bouchard, Linda S Musil, Ales Cvekl
BACKGROUND: The tissue-specific transcriptional programs during normal development require tight control by distal cis-regulatory elements, such as enhancers, with specific DNA sequences recognized by transcription factors, coactivators, and chromatin remodeling enzymes. Gata3 is a sequence-specific DNA-binding transcription factor that regulates formation of multiple tissues and organs, including inner ear, lens, mammary gland, T-cells, urogenital system, and thyroid gland. In the eye, Gata3 has a highly restricted expression domain in the posterior part of the lens vesicle; however, the underlying regulatory mechanisms are unknown...
November 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/30204931/ccbe1-is-required-for-coronary-vessel-development-and-proper-coronary-artery-stem-formation-in-the-mouse-heart
#20
Fernando Bonet, Paulo N G Pereira, Oriol Bover, Sara Marques, José M Inácio, José A Belo
BACKGROUND: Proper coronary vasculature development is essential for late-embryonic and adult heart function. The developmental regulation of coronary embryogenesis is complex and includes the coordinated activity of multiple signaling pathways. CCBE1 plays an important role during lymphangiogenesis, enhancing VEGF-C signaling, which is also required for coronary vasculature formation. However, whether CCBE1 plays a similar role during coronary vasculature development is still unknown...
October 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
journal
journal
30931
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"