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Developmental Dynamics: An Official Publication of the American Association of Anatomists

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https://www.readbyqxmd.com/read/27884054/morphoregulatory-pathways-in-prostate-ductal-development
#1
REVIEW
Monica Montano, Wade Bushman
The mouse prostate is a male sex-accessory gland comprised of a branched ductal network arranged into three separate bilateral lobes: the anterior, dorsolateral, and ventral lobes. Prostate ductal development is the primary morphogenetic event in prostate development and requires a complex regulation of spatiotemporal factors. This review provides an overview of prostate development and the major genetic regulators and signaling pathways involved. To identify new areas for further study, we briefly highlight the likely important, but relatively understudied, role of the extracellular matrix (ECM)...
November 24, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27884048/microrna-142-is-a-multifaceted-regulator-in-organogenesis-homeostasis-and-disease
#2
REVIEW
A Shrestha, R T Mukhametshina, S Taghizadeh, E Vásquez-Pacheco, H Cabrera-Fuentes, A Rizvanov, B Mari, G Carraro, S Bellusci
Over the last decade, microRNA-142 (miR-142) is emerging as a major regulator of cell fate decision in the hematopoietic system. However, miR-142 is expressed in many other tissues and recent evidence suggest that it may play a more pleiotropic role during embryonic development. In addition, miR-142 has been shown to play important functions in disease. miR-142 displays a functional role in cancer, virus infection, inflammation and immune tolerance. Both a guide strand (miR-142-3p) and passenger strand (miR-142-5p) are generated from the miR-142 hairpin...
November 24, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27884045/retinoic-acid-signaling-regulates-krt5-and-krt14-independently-of-stem-cell-markers-in-submandibular-salivary-gland-epithelium
#3
Timur M Abashev, Melissa A Metzler, Diana M Wright, Lisa L Sandell
BACKGROUND: Retinoic Acid (RA), the active metabolite of Vitamin A, has been demonstrated to be important for growth and branching morphogenesis of mammalian embryonic salivary gland epithelium. However, it is not known whether RA functions directly within epithelial cells or in associated tissues that influence morphogenesis of salivary epithelium. Moreover, downstream targets of RA regulation have not been identified. RESULTS: Here we show that canonical RA signaling occurs in multiple tissues of embryonic mouse salivary glands, including epithelium, associated parasympathetic ganglion neurons, and non-neuronal mesenchyme...
November 24, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27870483/transcriptome-analysis-of-the-regenerating-tail-versus-the-scarring-limb-in-lizard-reveals-pathways-leading-to-successful-versus-unsuccessful-organ-regeneration-in-amniotes
#4
Nicola Vitulo, Luisa Dalla Valle, Tatjana Skobo, Giorgio Valle, Lorenzo Alibardi
BACKGROUND: lizards are amniotes regenerating the tail but not the limb and no information on their different gene expression is available. RESULTS: transcriptomes of regenerating tail and limb blastemas show differences in gene expression between the two organs. In tail blastema snoRNAs and Wnt signals appear up-regulated probably in association with the Apical Epidermal Peg (AEP), an epithelial region that sustains tail regeneration but is absent in the limb. A balance between pro-oncogenes and tumor suppressors is likely present in tail blastema allowing a regulated proliferation...
November 21, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27859991/signaling-networks-in-joint-development
#5
REVIEW
Joanna E Salva, Amy E Merrill
Here we review studies identifying regulatory networks responsible for synovial, cartilaginous, and fibrous joint development. Synovial joints, characterized by the fluid-filled synovial space between the bones, are found in high-mobility regions and are the most common type of joint. Cartilaginous joints unite adjacent bones through either a hyaline cartilage or fibrocartilage intermediate. Fibrous joints, which include the cranial sutures, form a direct union between bones through fibrous connective tissue...
November 18, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27859941/adhesion-g-protein-coupled-receptors-and-extracellular-matrix-proteins-roles-in-myelination-and-glial-cell-development
#6
REVIEW
Paulomi Mehta, Xianhua Piao
BACKGROUND: Adhesion G protein-coupled receptors (aGPCRs) are a large family of transmembrane proteins that play important roles in many processes during development, primarily through cell-cell and cell-extracellular matrix (ECM) interactions. In the nervous system, they have been linked to the complex process of myelination, both in the central and peripheral nervous system. RESULTS: GPR126 is essential in Schwann cell-mediated myelination in the peripheral nervous system (PNS), while GPR56 is involved in oligodendrocyte development central nervous system (CNS) myelination...
November 18, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27859869/signaling-pathways-in-mammalian-preimplantation-development-linking-cellular-phenotypes-to-lineage-decisions
#7
REVIEW
Sergio Menchero, Teresa Rayon, Maria Jose Andreu, Miguel Manzanares
The first stages of mammalian development, before implantation of the embryo in the maternal uterus, result in the establishment of three cell populations in the blastocyst: trophectoderm, epiblast, and primitive endoderm. These events involve only a small number of cells, and are initiated by morphological differences among them related to cell adhesion and polarity. Much attention has been paid to the master transcription factors that are critical for establishing and maintaining early lineage choices. Nevertheless, a large body of work also reveals that additional molecular mechanisms are involved...
November 18, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27783451/therapeutic-and-pathological-roles-of-fibroblast-growth-factors-in-pulmonary-diseases
#8
REVIEW
Elie El Agha, Werner Seeger, Saverio Bellusci
Fibroblast growth factors (FGFs) constitute a large family of polypeptides that are involved in many biological processes, ranging from prenatal cell-fate specification and organogenesis to hormonal and metabolic regulation in postnatal life. During embryonic development, these growth factors are important mediators of the crosstalk among ectoderm, mesoderm and endoderm-derived cells and they instruct the spatial and temporal growth of organs and tissues such as the brain, bone, lung, gut etc. The involvement of FGFs in postnatal lung homeostasis is a growing field and there is emerging literature about their roles in lung pathophysiology...
October 26, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27761977/concomitant-differentiation-of-a-population-of-mouse-embryonic-stem-cells-into-neuron-like-cells-and-schwann-cell-like-cells-in-a-slow-flow-microfluidic-device
#9
Poornapriya Ramamurthy, Joshua B White, Joong Yull Park, Richard I Hume, Fumi Ebisu, Flor Mendez, Shuichi Takayama, Kate F Barald
BACKGROUND: To send meaningful information to the brain, an inner ear cochlear implant (CI) must become closely coupled to as large and healthy a population of remaining Spiral Ganglion Neurons (SGN) as possible. Inner ear gangliogenesis depends on macrophage migration inhibitory factor (MIF), a directionally attractant neurotrophic cytokine made by both Schwann and supporting cells (Bank et al., 2012). MIF-induced mouse embryonic stem cell (mESC)-derived "neurons" could potentially substitute for lost or damaged SGN...
October 19, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27756109/separate-development-of-the-maxilla-and-mandible-is-controlled-by-regional-signaling-of-the-maxillomandibular-junction-during-avian-development
#10
Hye-Jin Tak, Tae-Jin Park, Zhenngu Piao, Sang-Hwy Lee
BACKGROUND: Syngnathia is a congenital craniofacial disorder characterized by bony or soft tissue fusion of upper and lower jaws. Previous studies suggested some causative signals, such as Foxc1 or Bmp4, cause the disruption of maxillomandibular identity, but their location and the interactive signals involved remain unexplored. We wanted to examine the embryonic origin of syngnathia based on the assumption that it may be located at the separation between the maxillary and mandibular processes...
October 18, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27750398/vascular-endothelial-growth-factor-control-mechanisms-in-skeletal-growth-and-repair
#11
Kai Hu, Bjorn R Olsen
Vascular Endothelial Growth factor A (VEGF) is a critical regulator of vascular development, postnatal angiogenesis and homeostasis, and it is essential for bone development and repair. Blood vessels serve both as structural templates for bone formation and they provide essential cells, growth factors and minerals needed for synthesis and mineralization, as well as turnover, of the extracellular matrix in bone. Through its regulation of angiogenesis, VEGF contributes to coupling of osteogenesis to angiogenesis, and it directly controls the differentiation and function of osteoblasts and osteoclasts...
October 17, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27748998/lung-development-requires-an-active-erk-mapk-pathway-in-the-lung-mesenchyme
#12
Olivier Boucherat, Kim Landry-Truchon, Rifdat Aoidi, Nicolas Houde, Valérie Nadeau, Jean Charron, Lucie Jeannotte
BACKGROUND: Reciprocal epithelial-mesenchymal communications are critical throughout lung development, dictating branching morphogenesis and cell specification. Numerous signaling molecules are involved in these interactions but how epithelial-mesenchymal crosstalk is coordinated remains unclear. The ERK/MAPK pathway transduces several important signals in lung formation. Epithelial inactivation of both Mek genes, encoding ERK/MAPK kinases, causes lung agenesis and death. Conversely, Mek mutation in mesenchyme results in lung hypoplasia, trachea cartilage malformations, kyphosis, omphalocele and death...
October 17, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27739126/non-neuronal-roles-for-the-reelin-signaling-pathway
#13
Elvira Khialeeva, Ellen M Carpenter
The reelin signaling pathway has been established as an important regulator of cell migration during development of the central nervous system, and disruptions in reelin signaling alter the positioning of many types of neurons in the developing central nervous system. Reelin is a large extracellular matrix glycoprotein and governs cell migration through activation of multiple intracellular signaling events via the receptors ApoE receptor 2 (ApoER2) and Very Low Density Lipoprotein Receptor (VLDLR), and the intracellular adaptor protein Disabled-1 (Dab1)...
October 14, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27696611/prdm1-blimp1-is-widely-distributed-to-the-nascent-fetal-placental-interface-in-the-mouse-gastrula
#14
Maria M Mikedis, Karen M Downs
BACKGROUND: PRDM1 is a transcriptional repressor that contributes to primordial germ cell (PGC) development. During early gastrulation, epiblast-derived PRDM1 is thought to be restricted to a lineage-segregated germ line in the allantois. However, given recent findings that PGCs overlap an allantoic progenitor pool that contributes widely to the fetal-umbilical interface, posterior PRDM1 may also contribute to soma. RESULTS: Within the posterior mouse gastrula (early streak, 12-s stages, embryonic days ∼6...
October 3, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27666728/cre-inducible-site-specific-recombination-in-zebrafish-oligodendrocytes
#15
Alejandro Pinzon-Olejua, Cornelia Welte, Avinash Chekuru, Viktoria Bosak, Michael Brand, Stefan Hans, Claudia A O Stuermer
BACKGROUND: The conditional Cre/lox system has recently emerged as a valuable tool for studies on both embryonic and adult Zebrafish. Temporal control and site-specific recombination are achieved by using the ligand-inducible CreER(T2) and administration of the drug tamoxifen (TAM) or its active metabolite, 4-Hydroxytamoxifen (4-OHT). RESULTS: Here we report the generation of a transgenic Zebrafish line, which expresses an mCherry-tagged variant of CreER(T2) under the control of the myelin basic protein a (mbpa) promoter...
September 26, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27666927/conserved-and-divergent-expression-patterns-of-markers-of-axial-development-in-the-laboratory-opossum-monodelphis-domestica
#16
Michio Yoshida, Eriko Kajikawa, Daisuke Yamamoto, Daisuke Kurokawa, Shigenobu Yonemura, Kensaku Kobayashi, Hiroshi Kiyonari, Shinichi Aizawa
BACKGROUND: Previous comparative studies suggest that the requirement for Nodal in epiblast and hypoblast development is unique to mammalians. Expression of anterior visceral endoderm (AVE) genes in the visceral endoderm and of their orthologs in the hypoblast may be unique to mammalians and avians, and is absent in the reptilian hypoblast. Axis formation in reptiles is signaled by the formation of the posterior marginal epiblast (PME), which expresses a series of primitive streak genes...
December 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27649280/head-regeneration-in-hemichordates-is-not-a-strict-recapitulation-of-development
#17
Shawn M Luttrell, Kirsten Gotting, Eric Ross, Alejandro Sánchez Alvarado, Billie J Swalla
BACKGROUND: Head or anterior body part regeneration is commonly associated with protostome, but not deuterostome invertebrates. However, it has been shown that the solitary hemichordate Ptychodera flava possesses the remarkable capacity to regenerate their entire nervous system, including their dorsal neural tube and their anterior head-like structure, or proboscis. Hemichordates, also known as acorn worms, are marine invertebrate deuterostomes that have retained chordate traits that were likely present in the deuterostome ancestor, placing these animals in a vital position to study regeneration and chordate evolution...
December 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27623309/coordinated-lymphangiogenesis-is-critical-in-lymph-node-development-and-maturation
#18
Yulia Ga-Eun Lee, Gou Young Koh
BACKGROUND: Lymph node (LN) formation requires multiple but coordinated signaling from intrinsic and extrinsic cellular components during embryogenesis. However, the contribution and role of lymphatic vessels (LVs) in LN formation and maturation are poorly defined. Here, using lymphatic-specific reporters, Prox1-GFP mice and Vegfc(+/LacZ) mice, we analyzed migration, assembly, and ingrowth of lymphatic endothelial cells (LECs) in LNs during pre- and postnatal development. RESULTS: Prox1(+) LECs form string-like connections rather than lymph sac-like structures until E14...
December 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27599668/human-derived-cardiomyocytes-a-decade-of-knowledge-after-the-discovery-of-induced-pluripotent-stem-cells
#19
REVIEW
Andrea Barbuti, Patrizia Benzoni, Giulia Campostrini, Patrizia Dell'Era
Ten years ago Yamanaka's lab identified a way to reprogram terminally differentiated cells to a pluripotent state, similar to that of embryonic stem cell. This procedure opened the road for the generation of postmitotic human cells, that have completely lost the replication potential. The initial excitement waned when it was observed that the cells produced by this method are somehow immature and do not resemble the adult phenotype. In the absence of cellular markers that recognize the various maturation steps of induced pluripotent stem cell-derived human cardiomyocytes, we propose to follow their maturation looking at their electrophysiological profile...
December 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27580352/probing-early-heart-development-to-instruct-stem-cell-differentiation-strategies
#20
REVIEW
Damelys Calderon, Evan Bardot, Nicole Dubois
Scientists have studied organs and their development for centuries and, along that path, described models and mechanisms explaining the developmental principles of organogenesis. In particular, with respect to the heart, new fundamental discoveries are reported continuously that keep changing the way we think about early cardiac development. These discoveries are driven by the need to answer long-standing questions regarding the origin of the earliest cells specified to the cardiac lineage, the differentiation potential of distinct cardiac progenitor cells, and, very importantly, the molecular mechanisms underlying these specification events...
December 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
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