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Cancer Epidemiology, Biomarkers & Prevention

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https://www.readbyqxmd.com/read/28420652/alcohol-intake-and-breast-cancer-risk-in-african-american-women-from-the-amber-consortium
#1
Lindsay A Williams, Andrew F Olshan, Chi-Chen Hong, Elisa V Bandera, Lynn Rosenberg, Ting-Yuan David Cheng, Kathryn L Lunetta, Susan E McCann, Charles Poole, Laurence N Kolonel, Julie R Palmer, Christine B Ambrosone, Melissa A Troester
Background: Alcohol is a recognized risk factor for invasive breast cancer, but few studies involve African American women.Methods: The current analysis included 22,338 women (5,108 cases of invasive breast cancer) from the African American Breast Cancer Epidemiology and Risk (AMBER) Consortium. The association between number of alcoholic drinks per week (dpw) and breast cancer was estimated using logistic regression, adjusting for potential confounders, and stratifying by breast cancer subtype.Results: Approximately 35% of controls were current drinkers at interview...
April 18, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28377419/thyroid-stimulating-hormone-thyroid-hormones-and-risk-of-papillary-thyroid-cancer-a-nested-case-control-study
#2
Huang Huang, Jennifer Rusiecki, Nan Zhao, Yingtai Chen, Shuangge Ma, Herbert Yu, Mary H Ward, Robert Udelsman, Yawei Zhang
BACKGROUND: The effects of thyroid-stimulating hormone (TSH) and thyroid hormones on the development of human papillary thyroid cancer (PTC) remain poorly understood. METHODS: The study population consisted of 741 (341 women, 300 men) histologically confirmed PTC cases and 741 matched controls with pre-diagnostic serum samples stored in the Department of Defense Serum Repository. Concentrations of TSH, total T3 (TT3), total T4 (TT4), and free T4 (FT4) were measured in serum samples...
April 4, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28377418/characterizing-genetic-susceptibility-to-breast-cancer-in-women-of-african-ancestry
#3
Ye Feng, Suhn K Rhie, Dezheng Huo, Edward A Ruiz-Narvaez, Stephen A Haddad, Christine B Ambrosone, Esther M John, Leslie Bernstein, Wei Zheng, Jennifer J Hu, Regina G Ziegler, Sarah Nyante, Elisa V Bandera, Sue Ann Ingles, Michael F Press, Sandra L Deming, Jorge L Rodriguez-Gil, Yonglan Zheng, Song Yao, Yoo Jeong Han, Temidayo O Ogundiran, Timothy R Rebbeck, Clement Adebamowo, Oladosu Ojengbede, Adeyinka G Falusi, Anselm Hennis, Barbara Nemesure, Stefan Ambs, William Blot, Qiuyin Cai, Lisa Signorello, Katherine L Nathanson, Kathryn L Lunetta, Lara E Sucheston-Campbell, Jeannette T Bensen, Stephen J Chanock, Loic Le Marchand, Andrew F Olshan, Laurence N Kolonel, David V Conti, Gerhard Coetzee, Daniel O Stram, Olufunmilayo I Olopade, Julie R Palmer, Christopher A Haiman
BACKGROUND: Genome-wide association studies have identified ~100 common genetic variants associated with breast cancer risk, the majority of which were discovered in women of European ancestry. Due to different patterns of linkage disequilibrium, many of these genetic markers may not represent signals in populations of African ancestry. METHODS: We tested 74 breast cancer risk variants and conducted fine-mapping of these susceptibility regions in 6,522 breast cancer cases and 7,643 controls of African ancestry from three genetic consortia (AABC, AMBER and ROOT)...
April 4, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28377417/cervical-infection-with-cutaneous-beta-and-mucosal-alpha-papillomaviruses
#4
Laura Sichero, Mariam El-Zein, Emily M Nunes, Silvaneide Ferreira, Eduardo L Franco, Luisa L Villa
BACKGROUND: Alpha-human papillomavirus (α-HPV) play a causal role in cervical cancer but little is known about the epidemiology of genital Beta-HPV infection. METHODS: We used Luminex and polymerase chain reaction (PCR) hybridization to detect β- and α-HPVs prevalence at enrolment and 12-months follow-up in cervical samples from 505 women enrolled in the Ludwig-McGill cohort study. We compared epidemiological correlates of both β- and α-HPVs and compared genotypes between these genera with respect to co-occurrence and association with cervical cytological abnormalities...
April 4, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28377416/spectrum-of-immune-related-conditions-associated-with-risk-of-keratinocyte-cancers-among-elderly-adults-in-the-united-states
#5
Elizabeth L Yanik, Ruth M Pfeiffer, D Michael Freedman, Martin A Weinstock, Elizabeth K Cahoon, Sarah T Arron, Matthew Chaloux, M Kari Connolly, Priyadharsini Nagarajan, Eric A Engels
Elevated keratinocyte carcinoma (KC) risk is present with several immune-related conditions, e.g., solid organ transplantation and non-Hodgkin lymphoma. Because many immune-related conditions are rare, their relationships with KC have not been studied. We used Medicare claims to identify cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) cases in 2012, and controls matched on sex and age. All subjects were aged 65-95 years, of white race, and had attended ≥1 dermatologist visit in 2010-2011...
April 4, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28377415/circadian-disruption-and-prostate-cancer-risk-an-updated-review-of-epidemiological-evidences
#6
Méyomo G Wendeu-Foyet, Florence Menegaux
Since the publication of the IARC Monograph in 2007 classifying night shift work leading to a disruption of circadian rhythm as probably carcinogenic to humans, there is an increasingly growing interest in understanding how circadian disruption may play a role in cancer development. This systematic review provides a comprehensive update on epidemiological evidences on circadian disruption and prostate cancer since the last review published in 2012. We identified 12 new studies evaluating the effects of several circadian disruptors such as night shift work, sleep patterns, and circadian genes in prostate cancer risk...
April 4, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28377414/diagnostic-distinction-of-malignant-melanoma-and-benign-nevi-by-a-gene-expression-signature-and-correlation-to-clinical-outcomes
#7
Jennifer Ko, Balwir Matharoo-Ball, Steven D Billings, Brian J Thomson, Jean Y Tang, Kavita Y Sarin, Emily Cai, Jinah Kim, Colleen Rock, Hillary Kimbrell, Darl D Flake, M Bryan Warf, Jonathan Nelson, Thaylon Davis, Catherine Miller, Kristen Rushton, Anne-Renee Hartman, Richard J Wenstrup, Loren E Clarke
BACKGROUND: Histopathologic examination alone can be inadequate for diagnosis of certain melanocytic neoplasms. Recently, a 23-gene expression signature was clinically validated as an ancillary diagnostic test to differentiate benign nevi from melanoma. The current study assessed the performance of this test in an independent cohort of melanocytic lesions against clinically proven outcomes. METHODS: Archival tissue from primary cutaneous melanomas and melanocytic nevi was obtained from four independent institutions and tested with the gene signature...
April 4, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28341758/high-salt-intake-is-associated-with-atrophic-gastritis-with-intestinal-metaplasia
#8
Ji Hyun Song, Young Sun Kim, Nam Ju Heo, Joo Hyun Lim, Sun Young Yang, Goh Eun Chung, Joo Sung Kim
BACKGROUND: Although several studies have investigated excessive salt intake as a risk factor for gastric precancerous lesions such as atrophic gastritis (AG) and intestinal metaplasia (IM), the evidence is insufficient to make conclusion. We evaluated the association between gastric precancerous lesions and salt intake. METHODS: From 2008 to 2015, the medical records of 728 subjects who underwent upper gastrointestinal endoscopy and sodium excretion in 24-hr urine tests were retrospectively reviewed...
March 24, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28341757/elevated-serum-levels-of-scd30-and-il-6-and-detectable-il-10-precede-classical-hodgkin-lymphoma-diagnosis
#9
Lynn I Levin, Elizabeth C Breen, Brenda M Birmann, Julie L Batista, Larry I Magpantay, Yuanzhang Li, Richard F Ambinder, Nancy E Mueller, Otoniel Martínez-Maza
BACKGROUND: We investigated whether an immune system environment characterized by elevated serum levels of B-cell activation molecules was associated with the subsequent development of classical Hodgkin lymphoma (cHL). METHODS: We measured serum levels of B cell stimulatory cytokines, interleukin (IL)-6 and IL-10, soluble CD30 (sCD30) and total IgE prior to cHL diagnosis in 103 cases and 206 matched controls with archived specimens in the DoD Department of Defense Serum Repository...
March 24, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28336582/high-mammographic-density-in-long-term-night-shift-workers-ddm-spain-var-ddm
#10
Ana Maria Pedraza-Flechas, Virginia Lope, Carmen Sánchez-Contador, Carmen Santamariña, Carmen Pedraz-Pingarrón, Pilar Moreo, María Ederra, Josefa Miranda-García, Carmen Vidal, Rafael Llobet, Nuria Aragonés, Dolores Salas-Trejo, Marina Pollán, Beatriz Pérez-Gómez
Background:Night-shift work (NSW) has been suggested as a possible cause of breast cancer (BC), and its association with mammographic density (MD), one of the strongest risk factors for BC, has been scarcely addressed. This study examined NSW and MD in Spanish women. Methods:The study covered 2752 women aged 45-68 years recruited in 2007-2008 in 7 population-based public BC screening centers, which included 243 women who had performed NSW for at least one year. Occupational data and information on potential confounders was collected by personal interview...
March 23, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28336581/differential-impact-of-symptom-prevalence-and-chronic-conditions-on-quality-of-life-in-cancer-survivors-and-non-cancer-individuals-a-population-study
#11
I-Chan Huang, Melissa M Hudson, Leslie L Robison, Kevin R Krull
BACKGROUND: To compare associations of symptom prevalence, chronic conditions, and health-related quality of life (HRQOL) between cancer survivors and non-cancer individuals using the U.S. National Health Interview Survey. METHODS: Study samples comprised 604 survivors and 6,166 non-cancer individuals. Symptoms included sensation abnormality, pain, fatigue, cognitive disturbance, depression, and anxiety. Physical and mental HRQOL was measured by the Patient-Reported Outcomes Measurement Information System...
March 23, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28325738/follow-the-north-star-why-space-place-and-power-matter-for-geospatial-approaches-to-cancer-control-and-health-equity
#12
EDITORIAL
Nancy Krieger
No abstract text is available yet for this article.
March 21, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28292923/aspirin-use-reduces-the-risk-of-aggressive-prostate-cancer-and-disease-recurrence-in-african-american-men
#13
Cheryl J Smith, Tiffany H Dorsey, Wei Tang, Symone V Jordan, Christopher A Loffredo, Stefan Ambs
BACKGROUND: Men of African descent experience a disproportionately high prostate cancer mortality. Intratumoral inflammation was found to be associated with aggressive prostate cancer. We and others have shown that prostate tumors in African-American (AA) patients harbor a distinct immune and inflammation signature when compared with European-American (EA) patients. These observations suggest that inflammation could be a driver of aggressive disease in men of African descent, leading to the hypothesis that an anti-inflammatory drug like aspirin could prevent disease progression...
March 14, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28292922/the-association-of-the-c-reactive-protein-inflammatory-biomarker-with-breast-cancer-incidence-and-mortality-in-the-women-s-health-initiative
#14
Sandahl H Nelson, Theodore M Brasky, Ruth E Patterson, Gail A Laughlin, Donna Kritz-Silverstein, Beatrice J Edwards, Dorothy Lane, Thomas E Rohan, Gloria Y F Ho, JoAnn E Manson, Andrea Z LaCroix
PURPOSE: To examine associations of pre-diagnosis high-sensitivity C-reactive (hsCRP) with breast cancer incidence and post-diagnosis survival and to assess whether associations are modified by Body Mass Index (BMI). METHODS: A prospective analysis of the Women's Health Initiative was conducted among 17,841 cancer free postmenopausal women with baseline hsCRP measurements. Cox proportional hazards models were used to examine associations between hsCRP concentrations and: 1) breast cancer risk (n cases=1,114) and 2) all-cause mortality after breast cancer diagnosis...
March 14, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28292921/genetic-determinants-of-1-3-butadiene-metabolism-and-detoxification-in-three-populations-of-smokers-with-different-risks-of-lung-cancer
#15
Emily J Boldry, Yesha M Patel, Srikanth Kotapati, Amanda Esades, Sungshim L Park, Maarit Tiirikainen, Daniel O Stram, Loic LeMarchand, Natalia Tretyakova
Background: 1,3-Butadiene (BD) is an important carcinogen in tobacco smoke that undergoes metabolic activation to DNA-reactive epoxides. These species can be detoxified via glutathione conjugation and excreted in urine as the corresponding N-acetylcysteine conjugates. We hypothesize that single nucleotide polymorphisms in BD-metabolizing genes may change the balance of BD bioactivation and detoxification in White, Japanese American, and African American smokers, potentially contributing to ethnic differences in lung cancer risk...
March 14, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28264876/low-cotinine-glucuronidation-results-in-higher-serum-and-saliva-cotinine-in-african-american-compared-to-white-smokers
#16
Sharon E Murphy, Christopher J Sipe, Kwangsoo Choi, Leah M Raddatz, Joseph S Koopmeiners, Eric C Donny, Dorothy K Hatsukami
BACKGROUND: Tobacco exposure is often quantified by serum or saliva concentrations of the primary nicotine metabolite, cotinine. However, average cotinine concentrations are higher in African American (AA) compared to Whites with similar smoking levels. Cotinine is metabolized by UGT2B10 and CYP2A6, and low UGT2B10 activity is common in AA, due to the prevalence of a UGT2B10 splice variant. METHODS: UGT2B10-activity was phenotyped in 1446 smokers (34% AA) by measuring the percentage of cotinine excreted as a glucuronide...
March 6, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28264875/prediagnostic-calcium-intake-and-lung-cancer-survival-a-pooled-analysis-of-12-cohort-studies
#17
Danxia Yu, Yumie Takata, Stephanie A Smith-Warner, William Blot, Norie Sawada, Emily White, Neal Freedman, Kim Robien, Edward L Giovannucci, Xuehong Zhang, Yikyung Park, Yu-Tang Gao, Rowan T Chlebowski, Arnulf Langhammer, Gong Yang, Gianluca Severi, Jonas Manjer, Kay-Tee Khaw, Elisabete Weiderpass, Linda M Liao, Neil E Caporaso, Steinar Krokstad, Kristian Hveem, Rashmi Sinha, Regina G Ziegler, Shoichiro Tsugsane, Yong-Bing Xiang, Mattias Johannson, Wei Zheng, Xiao-Ou Shu
BACKGROUND: Lung cancer is the leading cause of cancer death. Little is known about whether prediagnostic nutritional factors may affect survival. We examined the associations of prediagnostic calcium intake from foods and/or supplements with lung cancer survival. METHODS: The present analysis included 23,882 incident, primary lung cancer patients from 12 prospective cohort studies. Dietary calcium intake was assessed using food-frequency questionnaires at baseline in each cohort and standardized to caloric intake of 2000 kcal/d for women and 2500 kcal/d for men...
March 6, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28264874/a-prospective-cohort-study-of-cigarette-prices-and-smoking-cessation-in-older-smokers
#18
Victoria L Stevens, W Ryan Diver, Michal Stoklosa, W Dana Flanders, J Lee Westmaas, Ahmedin Jemal, Jeffrey M Drope, Susan M Gapstur, Eric J Jacobs
BACKGROUND: Cigarette price increases effectively prevent smoking initiation and reduce cigarette consumption among young smokers. However, the impact of cigarette prices on smoking cessation among older smokers is less clear, particularly for those aged 65 years and older, a group that is at highest risk of smoking-related disease and will almost double in the United States between 2012 and 2050. METHODS: Biennial questionnaires administered between 1997 and 2013 assessed smoking status for 9,446 Cancer Prevention Study-II Nutrition Cohort participants who were ≥50 years old and lived in Washington, DC and 48 states...
March 6, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28264873/genetically-predicted-telomere-length-is-not-associated-with-pancreatic-cancer-risk
#19
Samuel O Antwi, William R Bamlet, Brendan T Broderick, Kari G Chaffee, Ann L Oberg, Aminah Jatoi, Lisa A Boardman, Gloria M Petersen
BACKGROUND: Epidemiologic associations of leukocyte telomere length (LTL) and pancreatic ductal adenocarcinoma (PDAC) have been inconsistent owing, in part, to variation in telomere length (TL) assessment across studies. To overcome this limitation and address concerns of potential reverse causation, we used carriage of telomere-related alleles to genetically predict TL and examined its association with PDAC. METHODS: A case-control study of 1,500 PDAC cases and 1,500 controls, frequency-matched on age and sex was performed...
March 6, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28258053/improved-performance-of-serum-alpha-fetoprotein-for-hepatocellular-carcinoma-diagnosis-in-hcv-cirrhosis-with-normal-alanine-transaminase
#20
Ju Dong Yang, Jianliang Dai, Amit G Singal, Purva Gopal, Benyam Addissie, Mindie H Nguyen, Alex S Befeler, K Rajender Reddy, Myron Schwartz, Denise M Harnois, Hiroyuki Yamada, Gregory J Gores, Ziding Feng, Jorge A Marrero, Lewis R Roberts
BACKGROUND: The utility of alpha fetoprotein (AFP) for hepatocellular carcinoma (HCC) surveillance is controversial. We aimed to identify factors associated with elevated AFP and define the patients for whom AFP is effective for surveillance. METHODS: Data from the National Cancer Institute Early Detection Research Network Phase 2 HCC biomarker study (233 early stage HCC and 412 cirrhotic patients) were analyzed. We analyzed 110 early stage HCC and 362 cirrhotic HCV patients for external validation...
March 3, 2017: Cancer Epidemiology, Biomarkers & Prevention
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