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Cancer Epidemiology, Biomarkers & Prevention

Song-Yi Park, Neal D Freedman, Christopher A Haiman, Loic Le Marchand, Lynne R Wilkens, Veronica Wendy Setiawan
BACKGROUND: Coffee intake has been associated with risk of cancers, but the findings, mostly from studies in white populations, are inconsistent. We examined the association of coffee consumption with overall cancer incidence and specific cancer sites in a prospective study of African Americans, Native Hawaiians, Japanese Americans, Latinos and whites. METHODS: 167,720 participants of the Multiethnic Cohort in Hawaii and Los Angeles were included. Baseline coffee intake was assessed by a validated food-frequency questionnaire...
May 18, 2018: Cancer Epidemiology, Biomarkers & Prevention
Kristin Wallace, David N Lewin, Shaoli Sun, Clayton M Spiceland, Don C Rockey, Alexander V Alekseyenko, Jennifer D Wu, John A Baron, Anthony J Alberg, Elizabeth G Hill
BACKGROUND: Compared with Caucasian Americans (CAs), African Americans (AAs) with colorectal cancer (CRC) have poorer survival, especially younger age patients. A robust lymphocytic reaction within CRCs is strongly associated with better survival but whether immune response impacts the disparity in CRC survival is not known. METHODS: The study population was comprised of 211 histologically confirmed CRCs at the Medical University of South Carolina (159 CAs, 52 AAs) diagnosed between 01/01/2000 and 06/30/2013...
May 16, 2018: Cancer Epidemiology, Biomarkers & Prevention
Jiping Wang, Nancy L Cho, Ann G Zauber, Meier Hsu, Dawn Dawson, Amitabh Srivastava, Kisha A Mitchell-Richards, Sanford D Markowitz, Monica M Bertagnolli
BACKGROUND: The APC trial showed that cyclooxygenase-2 (Cox-2) inhibitor, celecoxib, decreased adenoma development in patients at high risk for colorectal cancer. A prospectively planned analysis of the APC trial tested the hypothesis that expression of target enzymes in adenomas removed before beginning study treatment would identify individuals at high risk of adenoma development, and/or predict response to Cox-2 inhibition. METHODS: Pre-treatment adenomas were examined using immunohistochemistry (IHC) to assess expression of Cox-2 (high vs...
May 16, 2018: Cancer Epidemiology, Biomarkers & Prevention
Rebecca E Graff, Eunyoung Cho, Mark A Preston, Alejandro Sanchez, Lorelei A Mucci, Kathryn M Wilson
BACKGROUND: Accumulating evidence suggests that dietary acrylamide intake is not associated with the risk of most cancers in humans. However, a meta-analysis of five epidemiological studies found a suggestion of an increased risk of kidney cancer with higher dietary acrylamide intake. METHODS: We investigated this association in the prospective Health Professionals Follow-up Study (1986-2014) and Nurses' Health Study (1980-2014) cohorts. Dietary acrylamide intake was calculated based on 46 acrylamide-containing foods reported on food frequency questionnaires completed every four years...
May 14, 2018: Cancer Epidemiology, Biomarkers & Prevention
Jennifer A Doherty, Laurie Grieshober, John R Houck, Matthew J Barnett, Jean de Dieu Tapsoba, Mark Thornquist, Ching-Yun Wang, Gary E Goodman, Chu Chen
BACKGROUND: Accumulating evidence suggests that short telomere length is associated with increased overall mortality, but the relationship with cancer mortality is less clear. We examined whether telomere length (global, and chromosome arm 5p- and 13q-specific) is associated with lung cancer mortality among cases from the Beta Carotene and Retinol Efficacy Trial of heavy smokers. METHODS: Telomere length was measured on average six years before diagnosis for 788 lung cancer cases...
May 9, 2018: Cancer Epidemiology, Biomarkers & Prevention
Shukui Wang, Xiangxiang Liu, Bei Pan, Li Sun, Xiaoxiang Chen, Kaixuan Zeng, Xiuxiu Hu, Tao Xu, Mu Xu
BACKGROUND: Colorectal cancer (CRC) is one of the most common cancers worldwide usually with poor prognosis due to the advanced stage when diagnosed. This study aimed to investigate whether specific circulating exosomal miRNAs could act as biomarkers for early diagnosis of CRC. METHODS: A total of 369 peripheral blood samples were included in this study. In the discovery phase, circulating exosomal miR-27a and miR-130a were selected after synthetical analysis of two GEO datasets and TCGA database...
May 8, 2018: Cancer Epidemiology, Biomarkers & Prevention
Gabriel Y Lai, Jian-Bing Wang, Stephanie J Weinstein, Dominick Parisi, Ronald L Horst, Katherine A McGlynn, Satu Männistö, Demetrius Albanes, Neal D Freedman
BACKGROUND: Although circulating 25-hydroxyvitamin D [25(OH)D] concentrations were linked to liver cancer and chronic liver disease (CLD) in laboratory studies, few epidemiologic studies have addressed the associations. METHODS: Within the ATBC Study, we measured 25(OH)D in baseline serum of 202 incident liver cancer cases and 225 CLD deaths that occurred during nearly 25 years of follow-up, and 427 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression...
May 2, 2018: Cancer Epidemiology, Biomarkers & Prevention
Brandilyn A Peters, Marjorie L McCullough, Mark P Purdue, Neal D Freedman, Caroline Y Um, Susan M Gapstur, Richard B Hayes, Jiyoung Ahn
BACKGROUND: The oral microbiota play a central role in oral health, and possibly in carcinogenesis. Research suggests coffee and tea consumption may have beneficial health effects. We examined the associations of these common beverages with the oral ecosystem in a large cross-sectional study. METHODS: We assessed oral microbiota in mouthwash samples from 938 participants in two U.S. cohorts using 16S rRNA gene sequencing. Coffee and tea intake were assessed from food frequency questionnaires...
April 27, 2018: Cancer Epidemiology, Biomarkers & Prevention
Isobel M Poynten, Tim Waterboer, Fengyi Jin, David J Templeton, Richard J Hillman, Carmella Law, Alyssa Cornall, Sepehr Tabrizi, Jennifer M Roberts, Suzanne M Garland, Christopher K Fairley, Andrew E Grulich
BACKGROUND: Gay and bisexual men (GBM) are at disproportionately high risk of anal cancer. The precursor lesions, high grade squamous intra-epithelial lesions (HSIL) are very common and it is evident that not all HSIL progresses to cancer. The serological response to anal HPV in GBM has not been well characterised Methods:The Study of the Prevention of Anal Cancer is an ongoing cohort study of GBM aged 35 years and older. At six visits over three years, anal samples are collected for cytology, HPV DNA testing and histology...
April 26, 2018: Cancer Epidemiology, Biomarkers & Prevention
Ted Gansler, Roma A Shah, Ying Wang, Victoria L Stevens, Baiyu Yang, Christina C Newton, Susan M Gapstur, Eric J Jacobs
BACKGROUND: Prior studies of prostate cancer survivors suggest that smoking might be associated with higher prostate cancer-specific mortality (PCSM) after diagnosis with prostate cancer. However, most of these studies were small and questions remain regarding this association's strength and whether it persists after adjustment for stage and Gleason score. METHODS: This analysis included men diagnosed with nonmetastatic prostate cancer between enrollment in the Cancer Prevention Study-II Nutrition Cohort in 1992-1993 and June 2013...
April 26, 2018: Cancer Epidemiology, Biomarkers & Prevention
Chun-Nan Kuo, Jen-Jung Pan, Ya-Wen Huang, Hui-Ju Tsai, Wei-Chiao Chang
BACKGROUND: Cyclooxygenes-2 overexpression may contribute to colorectal cancer (CRC) occurrence. Aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) can reduce CRC recurrence, but the efficacy of primary prevention in Asian populations is still elusive. Thus, we examined the primary preventive efficacy of aspirin and NSAIDs on CRC incidence in Taiwan. METHODS: A nested case-control study was conducted using the National Health Insurance Research Database in Taiwan...
April 25, 2018: Cancer Epidemiology, Biomarkers & Prevention
Eric Jorgenson, Helene Choquet, Jie Yin, Maryam Asgari
BACKGROUND: Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer in America, and its incidence is substantially higher in men than women, but the reasons for the difference are unknown. We explored whether common mitochondrial DNA (mtDNA) haplogroups, which have been associated with cancer risk, and in particular squamous cell carcinoma risk arising in other organs, could explain this biological sex difference in cSCC susceptibility. METHODS: We performed a retrospective cohort study using data from the Genetic Epidemiology Research in Adult Health and Aging cohort comprised of 67,868 non-Hispanic white subjects (7,701 cSCC cases and 60,167 controls)...
April 25, 2018: Cancer Epidemiology, Biomarkers & Prevention
Weizhi Wang, Mulong Du, Zheng Li, Lei Zhang, Qing Li, Zhipeng Xu, Bowen Li, Linjun Wang, Fengyuan Li, Diancai Zhang, Hao Xu, Li Yang, Weida Gong, Fulin Qiang, Zhengdong Zhang, Zekuan Xu
BACKGROUND: Single nucleotide polymorphisms (SNPs) in the promoter region of microRNAs (miRNAs) have been reported to be associated with cancer prognosis. Our previous study found that miR-146b had a strong correlation with the stage classification of gastric cancer and contributed to tumor progression. The present study was aimed at investigating whether an SNP located in the promoter region of miR-146b could affect the survival rate of gastric cancer. METHODS: Using bioinformatics tools, we identified one SNP (rs1536309) that is located in the miR-146b promoter...
April 23, 2018: Cancer Epidemiology, Biomarkers & Prevention
Shengfeng Wang, Temidayo O Ogundiran, Adeyinka Ademola, Olayiwola A Oluwasola, Adewunmi O Adeoye, Adenike Sofoluwe, Imran Morhason-Bello, Stella O Odedina, Imaria Agwai, Clement Adebamowo, Millicent Obajimi, Oladosu Ojengbede, Olufunmilayo I Olopade, Dezheng Huo
BACKGROUND: Risk prediction models have been widely used to identify women at higher risk of breast cancer. We aim to develop a model for absolute breast cancer risk prediction for Nigerian women. METHODS: A total of 1,811 breast cancer cases and 2,225 controls from the Nigerian Breast Cancer Study (NBCS, 1998~2015) were included. Subjects were randomly divided into the training and validation sets. Incorporating local incidence rates, multivariable logistic regressions were used to develop the model...
April 20, 2018: Cancer Epidemiology, Biomarkers & Prevention
Emma H Allott, Sarah C Markt, Lauren E Howard, Adriana C Vidal, Daniel M Moreira, Ramiro Castro-Santamaria, Gerald L Adriole, Lorelei A Mucci, Stephen J Freedland
BACKGROUND: Prostate cancer (PC) incidence rates vary 25-fold worldwide. Differences in PSA screening are largely, but not entirely, responsible. We examined geographic differences in prevalence of histologic prostate inflammation and subsequent PC risk. METHODS: 7,000 non-Hispanic white men were enrolled in the REDUCE trial from Europe (n=4,644), North America (n=1,746), South America (n=466), and Australia/New Zealand (n=144). Histologic inflammation in baseline negative prostate biopsies was classified as chronic (lymphocytes/macrophages) or acute (neutrophils)...
April 18, 2018: Cancer Epidemiology, Biomarkers & Prevention
Daniel W Cramer, Raina N Fichorova, Kathryn L Terry, Hidemi S Yamamoto, Allison F Vitonis, Eva Ardanaz, Dagfinn Aune, Heiner Boeing, Jenny Brändstedt, Marie-Christine Boutron-Ruault, Maria-Dolores Chirlaque, Miren Dorronsoro, Laure Dossus, Eric J Duell, Inger T Gram, Marc J Gunter, Louise Hansen, Annika Idahl, Theron Johnson, Kay-Tee Khaw, Vittorio Korgh, Marina Kvaskoff, Amalia Mattiello, Giuseppe Matullo, Melissa A Merritt, Björn Nodin, N Charlotte Onland-Moret, Philippos Orfanos, Domenico Palli, Eleni Peppa, J Ramón Quirós, Maria-José Sànchez-Pérez, Gianluca Severi, Ruth C Travis, Antonia Trichopoulou, Rosario Tumino, Elisabete Weiderpass, Renée Turzanski Fortner, Rudolf Kaaks
BACKGROUND: Neoplastic and non-neoplastic events may raise levels of mucins, CA15.3 and CA125, and generate antibodies against them; but their impact on epithelial ovarian cancer (EOC) risk has not been fully defined. METHODS: CA15.3, CA125, and IgG1 antibodies against them were measured in 806 women who developed EOC and 1,927 matched controls from the European Prospective Investigation of Nutrition and Cancer. Associations between epidemiologic factors and anti-mucin antibodies were evaluated using generalized linear models; EOC risks associated with anti-mucin antibodies, by themselves or in combination with respective antigens, were evaluated using conditional logistic regression...
April 16, 2018: Cancer Epidemiology, Biomarkers & Prevention
M Ángeles Villaronga, Francisco Hermida-Prado, Rocio Granda-Diaz, Sofia T Menendez, Saul Alvarez-Teijeiro, Miquel Quer, Isabel Vilaseca, Eva Allonca, Marta Garzón-Arango, Victoria Sanz-Moreno, Aurora Astudillo, Juan P Rodrigo, Juana M García-Pedrero
BACKGROUND: Cortactin (CTTN) and the Focal Adhesion Kinase (FAK) are two major candidate genes to respectively drive 11q13- and 8q24-associated aggressive behavior in various cancers. Recent evidence uncovered their clinical relevance in early stages of tumorigenesis as promising biomarkers for cancer risk assessment. METHODS: Using a multicenter validation study CTTN and FAK expression was evaluated by immunohistochemistry in a cohort of 109 patients with laryngeal precancerous lesions, and correlated with clinicopathologic parameters and laryngeal cancer risk...
April 13, 2018: Cancer Epidemiology, Biomarkers & Prevention
Michael J Madsen, Stacey Knight, Carol Sweeney, Rachel E Factor, Mohamed E Salama, Inge J Stijleman, Venkatesh Rajamanickam, Bryan E Welm, Sasi Arunachalam, Brandt Jones, Rakesh Rachamadugu, Kerry Rowe, Melissa Cessna, Alun Thomas, Lawrence H Kushi, Bette Caan, Philip S Bernard, Nicola J Camp
BACKGROUND: Breast tumor subtyping has failed to provide impact in susceptibility genetics. The PAM50 assay categorizes breast tumors into: Luminal A, Luminal B, HER2-enriched and Basal-like. However, tumors are often more complex than simple categorization can describe. The identification of heritable tumor characteristics has potential to decrease heterogeneity and increase power for gene-finding. METHODS: We used 911 sporadic breast tumors with PAM50 expression data to derive tumor dimensions using principal components (PC)...
April 12, 2018: Cancer Epidemiology, Biomarkers & Prevention
Hong Xu, Yueming Chen, Xueyan Dong, Xianjun Wang
BACKGROUND: Increasing studies suggest that lncRNAs involving in carcinogenesis of human cancers, which might be used as diagnostic biomarkers for cancers Methods:Three hundred and one participants were recruited in the first part of the study including HCC group (n = 60), LC group (n = 85), CHB group (n = 96) and healthy subjects (n = 60). In the second part, we collected 55 HCC patients, 60 CHB patients and 60 healthy subjects as an independent cohort to validate the ability of the experiential lncRNAs for identifying HCC from CHB...
April 12, 2018: Cancer Epidemiology, Biomarkers & Prevention
Trang VoPham, Matthew D Weaver, Céline Vetter, Jaime E Hart, Rulla M Tamimi, Francine Laden, Kimberly A Bertrand
BACKGROUND: Circadian misalignment may increase the risk of developing hepatocellular carcinoma (HCC). The aim of this study was to examine the association between distance from time zone meridian, a proxy for circadian misalignment, and HCC risk in the U.S. adjusting for known HCC risk factors. METHODS: Surveillance, Epidemiology, and End Results (SEER) provided information on 56,347 HCC cases diagnosed between 2000 and 2014 from 16 population-based cancer registries in the U...
April 10, 2018: Cancer Epidemiology, Biomarkers & Prevention
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