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Cancer Epidemiology, Biomarkers & Prevention

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https://www.readbyqxmd.com/read/28522448/estimation-of-the-number-of-women-living-with-metastatic-breast-cancer-in-the-united-states
#1
Angela B Mariotto, Ruth Etzioni, Marc Hurlbert, Lynne Penberthy, Musa Mayer
Background: Distant metastatic breast cancer (MBC), including metastases found at diagnosis (de novo) and those occurring later (recurrence), represents the most severe form of the disease, when resource utilization is most intensive. Yet, the number of women living with MBC in the United States is unknown. The objective of this article is to use population-based data to estimate the prevalence of MBC.Methods: We used a back-calculation method to estimate MBC prevalence from U.S. breast cancer mortality and survival from the Surveillance, Epidemiology and End Results (SEER) registries...
May 18, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28515111/racial%C3%A2-differences-in-adjuvant-endocrine-therapy-use-and-discontinuation-in-association-with-mortality-among-medicare-breast-cancer-patients-by-receptor-status
#2
Albert J Farias, Xianglin L Du
BACKGROUND: There are racial disparities in breast cancer mortality. Our purpose was to determine whether racial/ethnic differences in use and discontinuation of AET differed by hormone receptor status and whether discontinuation was associated with mortality. METHODS: We conducted a retrospective cohort study with SEER/Medicare dataset of women age 65 years or older diagnosed with stage I-III breast cancer in Medicare Part-D from 2007-2009, stratified by hormone receptor status...
May 17, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28515110/do-men-and-women-need-to-be-screened-differently-with-faecal-immunochemical-testing-a-cost-effectiveness-analysis
#3
Miriam P van der Meulen, Atija Kapidzic, Monique E van Leerdam, Alex van der Steen, Ernst J Kuipers, Manon C Spaander, Harry J de Koning, Lieke Hol, Iris Lansdorp-Vogelaar
BACKGROUND: Several studies suggest test characteristics for the faecal immunochemical test (FIT) differ by gender, triggering a debate whether men and women should be screened differently. We used the microsimulation model MISCAN-Colon to evaluate whether screening stratified by gender is cost-effective. METHODS: We estimated gender-specific FIT characteristics based on first round positivity and detection rates observed in a FIT screening pilot (CORERO-1). Subsequently, we used the model to estimate harms, benefits and costs of 480 gender-specific FIT screening strategies and compared them with uniform screening...
May 17, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28515109/updated-review-of-prevalence-of-major-risk-factors-and-use-of-screening-tests-for-cancer-in-the-united-states
#4
Ann Goding Sauer, Rebecca L Siegel, Ahmedin Jemal, Stacey A Fedewa
Much of the suffering and death from cancer could be prevented by more systematic efforts to reduce tobacco use and obesity, improve diet, and increase physical activity and use of established vaccines and screening tests. Monitoring the prevalence of cancer risk factors and preventive tests helps guide cancer prevention and early detection efforts. We provide an updated review, using data through 2015, of the prevalence of major risk factors, cancer screening, and vaccination for U.S. adults and youth. Cigarette smoking among adults decreased to 15...
May 17, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28515108/a-comparison-of-the-natural-history-of-hpv-infection-and-cervical-abnormalities-among-hiv-positive-and-hiv-negative-women-in-senegal-africa
#5
Hilary K Whitham, Stephen E Hawes, Haitao Chu, J Michael Oakes, Alan R Lifson, Nancy B Kiviat, Papa Salif Sow, Geoffrey S Gottlieb, Selly Ba, Marie P Sy, Shalini L Kulasingam
Background: There is evidence of an interaction between HIV and human papillomavirus (HPV) resulting in increased HPV-associated morbidity and cancer mortality among HIV-positive women. This study aims to determine how the natural history of cervical HPV infection differs by HIV status.Methods: A total of 1,320 women (47% were positive for HIV-1 and/or HIV-2) were followed for an average of two years in Senegal, West Africa between 1994 and 2010. Cytology (with a sub-sample of histology) and HPV DNA testing were performed at approximately 4-month intervals yielding data from over 7,900 clinic visits...
May 17, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28515107/a-randomized-double-blind-placebo-controlled-trial-of-the-effect-of-vitamin-d3-supplementation-on-breast-density-in-premenopausal-women
#6
Jacques Brisson, Sylvie Bérubé, Caroline Diorio, Benoit Masse, Julie Lemieux, Thierry Duchesne, Edgar Delvin, Reinhold Vieth, Martin J Yaffe, Jocelyne Chiquette
BACKGROUND: This double-blind, placebo-controlled parallel-group trial assessed whether oral supplementation with 1,000, 2,000 or 3,000 IU/day vitamin D3 over one year reduces percent mammographic breast density in premenopausal women. METHODS: The trial was conducted between October 2012 and June 2015, among premenopausal female volunteers from Quebec City (Quebec, Canada). Women were randomized with ratio 1:1:1:1 to one of four study arms (1,000, 2,000 or 3,000 IU/d vitamin D3 or placebo)...
May 17, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28506970/metformin-diabetes-and-survival-among-u-s-veterans-with-colorectal-cancer-response
#7
LETTER
Jessica K Paulus, Christina D Williams, Furha I Cossor, Michael J Kelley, Robert E Martell
No abstract text is available yet for this article.
May 15, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28506969/the-obesity-paradox-and-cancer-letter
#8
LETTER
Raffaella Mormile
No abstract text is available yet for this article.
May 15, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28506968/the-obesity-paradox-in-cancer-moving-beyond-bmi-response
#9
LETTER
Shlomit Strulov Shachar, Grant R Williams
No abstract text is available yet for this article.
May 15, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28506967/aspirin-and-pancreatic-cancer-letter
#10
LETTER
Raffaella Mormile
No abstract text is available yet for this article.
May 15, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28506966/metformin-diabetes-and-survival-among-u-s-veterans-with-colorectal-cancer-letter
#11
LETTER
Nasra N Alam, Ellena Badrick, Matthew Sperrin, Andrew G Renehan
No abstract text is available yet for this article.
May 15, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28506965/explaining-the-obesity-paradox-the-association-between-body-composition-and-colorectal-cancer-survival-c-scans-study
#12
Bette J Caan, Jeffrey A Meyerhardt, Candyce H Kroenke, Stacey Alexeeff, Jingjie Xiao, Erin Weltzien, Elizabeth Cespedes Feliciano, Adrienne L Castillo, Charles P Quesenberry, Marilyn L Kwan, Carla M Prado
Background: Body composition may partially explain the U-shaped association between body mass index (BMI) and colorectal cancer survival.Methods: Muscle and adiposity at colorectal cancer diagnosis and survival were examined in a retrospective cohort using Kaplan-Meier curves, multivariable Cox regression, and restricted cubic splines in 3,262 early-stage (I-III) male (50%) and female (50%) patients. Sarcopenia was defined using optimal stratification and sex- and BMI-specific cut points. High adiposity was defined as the highest tertile of sex-specific total adipose tissue (TAT)...
May 15, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28506964/population-based-precision-cancer-screening-letter
#13
LETTER
Karina Standahl Olsen, Eiliv Lund
No abstract text is available yet for this article.
May 15, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28506963/aspirin-and-pancreatic-cancer-response
#14
LETTER
Harvey A Risch
No abstract text is available yet for this article.
May 15, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28483970/total-and-free-circulating-vitamin-d-and-vitamin-d-binding-protein-in-relation-to-colorectal-cancer-risk-in-a-prospective-study-of-african-americans
#15
Shaneda Warren Andersen, Xiao-Ou Shu, Qiuyin Cai, Nikhil K Khankari, Mark D Steinwandel, Peter W Jurutka, William J Blot, Wei Zheng
BACKGROUND: Previous studies rarely evaluated the associations between vitamin D binding protein and free vitamin D with colorectal cancer (CRC) risk. We assessed these biomarkers and total 25-hydroxyvitamin D in relation to CRC risk in a sample of African Americans. METHODS: Cases comprised 224 African American participants of the Southern Community Cohort Study diagnosed with incident CRC. Controls (N=440) were selected through incidence density sampling and matched to cases on age, sex, and race...
May 8, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28483969/association-of-metabolic-syndrome-and-human-papillomavirus-virus-infection-in-men-and-women-residing-in-the-unites-states
#16
Jennifer C Molokwu, Eribeth Penaranda, David S Lopez, Alok Dwivedi, Christopher Dodoo, Navkiran Shokar
BACKGROUND: An estimated 33 percent of adults in the US have metabolic syndrome which has been associated with an increased risk for various cancer types. Theories of synergism among components of MetS that increase cancer risk via chronic inflammation and oxidative stress have been proposed. We hypothesize that men and women with MetS may have compromised immunological response resulting in increased risk for persistent HPV infection. The goal of this study is to determine the association of MetS with HPV types 6, 11, 16 and 18 and to explore variation of these associations by gender using data from a national survey...
May 8, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28483968/pre-analytical-stability-of-antibodies-to-pathogenic-antigens
#17
Verity S Hodgkinson, Sam Egger, Fay Betsou, Tim Waterboer, Michael Pawlita, Angelika Michel, Mark S Baker, Emily Banks, Freddy Sitas
BACKGROUND: Serological testing for antibodies against epitopes from pathogens is a valuable tool for investigating the relationship between infection and disease. This study comprehensively evaluates the impact of pre-analytic variation on antibody seropositivities to a selected set of antigens arising from delays in processing of blood samples, pre-processing storage-temperature and vacutainer-type. METHODS: We assessed peripheral blood collected from 29 volunteers in four different Vacutainer® types (ethylenediaminoetetraacetic-acid (EDTA), acid-citrate-dextrose (ACD), lithium heparin (LH) and serum separator tubes (SST)) and stored at 4◦C or room-temperature for 0, 1, 2, 3, 4, 5 and 6 days before processing...
May 8, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28450580/longitude-position-in-a-timezone-and-cancer-risk-in-the-united-states
#18
Fangyi Gu, Shangda Xu, Susan S Devesa, Fanni Zhang, Elizabeth B Klerman, Barry I Graubard, Neil E Caporaso
BACKGROUND: Circadian disruption is a probable human carcinogen. From the eastern to western border of a timezone, social time is equal whereas solar time is progressively delayed, producing increased discrepancies between individuals' social and biological circadian time. Accordingly, western timezone residents experience greater circadian disruption and may be at an increased risk of cancer. METHODS: We examine associations between the position in a timezone (PTZ) and age-standardized county-level incidence rates for total cancers combined and 23 specific cancers by gender using the data of the Surveillance, Epidemiology, and End Results Program (2000-2012), including four million cancer diagnoses in white residents of 607 counties in 11 US states...
April 27, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28446546/conjunctival-ultraviolet-autofluorescence-as-a-measure-of-past-sun-exposure-in-children
#19
Cong Sun, Angela Pezic, David A Mackey, John B Carlin, Andrew Kemp, Justine A Ellis, Fergus J Cameron, Christine P Rodda, Terence Dwyer, Minas T Coroneo, Anne-Louise Ponsonby
BACKGROUND: Conjunctival ultraviolet autofluorescence (CUVAF) area detected from UVAF photographs is a recently developed potential marker for past sun exposure but its relationship with sun-related factors have not been fully investigated. METHODS: The study included 339 ethnically diverse and healthy children aged 5-15 years in Melbourne, Australia. Data were collected by questionnaire and examination at school. CUVAF area was measured using a computer programme and analysed as a continuous and dichotomous outcome (any/none)...
April 26, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28446545/a-pooled-analysis-of-15-prospective-cohort-studies-on-the-association-between-fruit-vegetable-and-mature-bean-consumption-and-risk-of-prostate-cancer
#20
Joshua Petimar, Kathryn M Wilson, Kana Wu, Molin Wang, Demetrius Albanes, Piet A van den Brandt, Michael B Cook, Graham G Giles, Edward L Giovannucci, Gary G Goodman, Phyllis J Goodman, Niclas Håkansson, Kathy Helzlsouer, Timothy J Key, Laurence N Kolonel, Linda M Liao, Satu Männistö, Marjorie L McCullough, Roger L Milne, Marian L Neuhouser, Yikyung Park, Elizabeth A Platz, Elio Riboli, Norie Sawada, Jeannette M Schenk, Shoichiro Tsugane, Bas Verhage, Ying Wang, Lynne R Wilkens, Alicja Wolk, Regina G Ziegler, Stephanie A Smith-Warner
BACKGROUND: Relationships between fruit, vegetable, and mature bean consumption and prostate cancer risk are unclear. METHODS: We examined associations between fruit and vegetable groups, specific fruits and vegetables, and mature bean consumption and prostate cancer risk overall, by stage and grade, and for prostate cancer mortality in a pooled analysis of 15 prospective cohorts, including 52,680 total cases and 3,205 prostate cancer deaths among 842,149 men. Diet was measured by a food frequency questionnaire or similar instrument at baseline...
April 26, 2017: Cancer Epidemiology, Biomarkers & Prevention
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