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Phytochemical Analysis: PCA

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https://www.readbyqxmd.com/read/28332747/ultra-performance-liquid-chromatography-hyphenated-with-quadrupole-orbitrap-mass-spectrometry-for-simultaneous-determination-of-necine-core-structure-pyrrolizidine-alkaloids-in-crotalaria-sessiliflora-l-without-all-corresponding-standards
#1
Wei Zhang, Wenbei Huai, Yi Zhang, Jincan Shen, Xunyou Tang, Xiujuan Xie, Ke Wang, Huajun Fan
INTRODUCTION: Crotalaria sessiliflora L. is a Chinese traditional herb for treatment of cutaneum carcinoma and cervical carcinoma. In addition to monocrotaline, coexisting pyrrolizidine alkaloids (PAs) also require further quantification for quality control and pharmaceutical uses of the herb. OBJECTIVE: To establish a UPLC-Q-Orbitrap/MS method of simultaneous determination of coexisting PAs with same parent structure for quality control and comprehensive researches of Crotalaria sessiliflora L...
March 23, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28317245/efficient-discovery-of-quality-control-markers-for-gastrodia-elata-tuber-by-fingerprint-efficacy-relationship-modelling
#2
Mingfang Li, Yuan Du, Long Wang, Lilong Jiang, Xiaodong Ma, Ping Zhou, Ping Li, Huijun Li
INTRODUCTION: Gastrodia elata tuber (GET) has been widely used in China as a famous herbal medicine. However, the quality control markers (QCMs) for GET still need further investigation. OBJECTIVE: To develop a rational strategy based on fingerprint-efficacy relationship modelling to discover the efficacy-related QCMs, using GET as a case study. METHODOLOGY: The high-performance liquid chromatography (HPLC) fingerprints of 13 batches of GET extracts were established and 10 common peaks were structurally characterised by HPLC coupled with quadrupole time-of-flight mass spectrometry (QTOF-MS)...
March 20, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28239915/rapid-analysis-of-corni-fructus-using-paper-spray-mass-spectrometry
#3
Yuan Guo, Zhixin Gu, Xuemei Liu, Jingjing Liu, Ming Ma, Bo Chen, Liping Wang
INTRODUCTION: Paper spray-mass spectrometry (PS-MS) is a kind of ambient MS technique for the rapid analysis of samples. Corni fructus has been widely used in traditional Chinese compound preparations and healthy food. However, a number of counterfeits of Corni fructus, such as Crataegi fructus, Lycii fructus, and grape skin are illegally sold in crude herb markets. Therefore, the development of a rapid and high-throughput quality evaluation method is important for ensuring the effectiveness and safety of the crude materials of Corni fructus...
February 26, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28233350/origin-discrimination-of-osmanthus-fragrans-var-thunbergii-flowers-using-gc-ms-and-uplc-pda-combined-with-multivariable-analysis-methods
#4
Fei Zhou, Yajing Zhao, Jiyu Peng, Yirong Jiang, Maiquan Li, Yuan Jiang, Baiyi Lu
INTRODUCTION: Osmanthus fragrans flowers are used as folk medicine and additives for teas, beverages and foods. The metabolites of O. fragrans flowers from different geographical origins were inconsistent in some extent. Chromatography and mass spectrometry combined with multivariable analysis methods provides an approach for discriminating the origin of O. fragrans flowers. OBJECTIVE: To discriminate the Osmanthus fragrans var. thunbergii flowers from different origins with the identified metabolites...
February 24, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28198114/immunoaffinity-knockout-of-saponin-glycosides-from-asparagus-racemosus-to-assess-anti-lipid-peroxidation
#5
Churanya Onlom, Watoo Phrompittayarat, Waraporn Putalun, Neti Waranuch, Kornkanok Ingkaninan
INTRODUCTION: Asparagus racemosus Willd (Asparagaceae family), known as Shatavari, is important in Ayurveda and traditional Thai medicines. The saponin glycosides, shatavarin I and IV are major constituents in its roots and may be responsible for their actions including protection against lipid peroxidation and carcinogenesis. OBJECTIVE: To develop an immunoaffinity column for isolating compounds with structures related to shatavarin IV from crude extracts of A...
February 15, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28198057/c18-cooh-silica-preparation-characterisation-and-its-application-in-purification-of-quaternary-ammonium-alkaloids-from-coptis-chinensis
#6
Qing Wang, Yao Long, Lin Yao, Mao Ye, Li Xu
INTRODUCTION: Traditional methods for isolating and purifying quaternary ammonium alkaloids from Coptis chinensis do not discriminate the target alkaloids from co-extractives. Mixed-mode analytical chromatography has the potential to improve the separation of analytes in more complex extracts and, when used in a solid-phase extraction mode, improve the purity of isolated compounds. OBJECTIVE: To examine the high-performance liquid chromatographic separation capabilities of a mixed-mode, silica-based adsorbent and its application to the purification of quaternary ammonium alkaloids from Coptis chinensis based on solid-phase extraction...
February 15, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28168765/prediction-of-anti-alzheimer-s-activity-of-flavonoids-targeting-acetylcholinesterase-in-silico
#7
Subrata Das, Monjur A Laskar, Satyajit D Sarker, Manabendra D Choudhury, Prakash Roy Choudhury, Abhijit Mitra, Shajarahtunnur Jamil, Siti Mariam A Lathiff, Siti Awanis Abdullah, Norazah Basar, Lutfun Nahar, Anupam D Talukdar
INTRODUCTION: Prenylated and pyrano-flavonoids of the genus Artocarpus J. R. Forster & G. Forster are well known for their acetylcholinesterase (AChE) inhibitory, anti-cholinergic, anti-inflammatory, anti-microbial, anti-oxidant, anti-proliferative and tyrosinase inhibitory activities. Some of these compounds have also been shown to be effective against Alzheimer's disease. OBJECTIVE: The aim of the in silico study was to establish protocols to predict the most effective flavonoid from prenylated and pyrano-flavonoid classes for AChE inhibition linking to the potential treatment of Alzheimer's disease...
February 7, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28146307/targeted-metabolomics-of-the-phenylpropanoid-pathway-in-arabidopsis-thaliana-using-reversed-phase-liquid-chromatography-coupled-with-tandem-mass-spectrometry
#8
Rohit Jaini, Peng Wang, Natalia Dudareva, Clint Chapple, John A Morgan
INTRODUCTION: The phenylpropanoid pathway is a source of a diverse group of compounds derived from phenylalanine, many of which are involved in lignin biosynthesis and serve as precursors for the production of valuable compounds, such as coumarins, flavonoids, and lignans. Consequently, recent efforts have been invested in mechanistically understanding monolignol biosynthesis, making the quantification of these metabolites vital. OBJECTIVE: To develop an improved and comprehensive analytical method for (i) extensively profiling, and (ii) accurately quantifiying intermediates of the monolignol biosynthetic network, using Arabidopsis thaliana as a model system...
February 1, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28124813/synthesis-of-quercetin-imprinted-polymer-spherical-particles-with-improved-ability-to-capture-quercetin-analogues
#9
Antonelle Pardo, Thomas Josse, Laetitia Mespouille, Bertrand Blankert, Philippe Dubois, Pierre Duez
INTRODUCTION: Molecularly imprinted polymers (MIPs) are composed of specific cavities able to selectively recognise a template molecule. Used as chromatographic sorbents, MIPs may not trap related structures due to the high rigidity of their cross-linking. OBJECTIVE: To improve the capture of quercetin analogues by modulating the synthesis strategy for a quercetin-imprinted polymer (Qu MIP). METHODOLOGY: An additional comonomer bearing a short oligoethylene glycol (OEG) unit was used to prepare a Qu MIP that was compared to a traditional one formulated in a similar fashion, but without the OEG-comonomer...
January 26, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28124812/an-insight-on-salting-out-assisted-liquid-liquid-extraction-for-phytoanalysis
#10
Inês M Valente, Manuela M Moreira, Pâmela Neves, Thiago da Fé, Luís M Gonçalves, Paulo J Almeida, José A Rodrigues
INTRODUCTION: Salting-out assisted liquid-liquid extraction (SALLE) is a technique that, although simple and not requiring any complex equipment, is very powerful and versatile. It has obtained growing interest in bioanalysis particularly when combined with chromatographic techniques. OBJECTIVES: Herein, fennel seeds (Foeniculum vulgare Mill.) were used as a case-study to show the application of SALLE in phytochemical analysis. MATERIAL AND METHODS: SALLE combined with HPLC-UV-MS/MS and GC-MS...
January 26, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28124803/employing-two-stage-derivatisation-and-gc-ms-to-assay-for-cathine-and-related-stimulant-alkaloids-across-the-celastraceae
#11
Luke R Tembrock, Corey D Broeckling, Adam L Heuberger, Mark P Simmons, Frank R Stermitz, Jessica M Uvarov
INTRODUCTION: Catha edulis (qat, khat, mirra) is a woody plant species that is grown and consumed in East Africa and Yemen for its stimulant alkaloids cathinone, cathine and norephedrine. Two Celastraceae species, in addition to qat, have been noted for their stimulant properties in ethnobotanical literature. Recent phylogenetic reconstructions place four genera in a clade sister to Catha edulis, and these genera are primary candidates to search for cathine and related alkaloids. OBJECTIVE: Determine if cathine or related alkaloids are present in species of Celastraceae other than Catha edulis...
January 26, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28111813/chemometric-based-identification-and-validation-of-specific-chemical-markers-for-geographical-seasonal-and-gender-variations-in-tinospora-cordifolia-stem-using-hplc-esi-qtof-ms-analysis
#12
Vikas Bajpai, Sunil Kumar, Awantika Singh, Jyotsana Singh, M P S Negi, Sumit Kumar Bag, Nikhil Kumar, Rituraj Konwar, Brijesh Kumar
INTRODUCTION: Tinospora cordifolia is a widely distributed medicinal plant used in various traditional and commercial Ayurvedic formulations. Due to the wide use of this plant it is important to know the extent of variability in the metabolite profile resulting from geographical location, season and gender. OBJECTIVE: To develop a statistical approach based on phytochemical markers for confident prediction of variations in metabolic profile and cytotoxicity due to geographical, seasonal and gender difference in T...
January 23, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28092423/-1-h-qnmr-quantification-of-annonaceous-acetogenins-in-crude-extracts-of-annona-muricata-l-fruit-pulp
#13
Natacha Bonneau, Timothé Cynober, Jean-Christophe Jullian, Pierre Champy
INTRODUCTION: Annonaceous acetogenins (AAGs) constitute a group of environmental neurotoxins, possibly implicated in sporadic atypical Parkinsonism/dementia complexes. The recent evidencing of complex mixtures of AAGs in edible fruits and derived food products requires efficient and practical analytical tools for an estimation of human exposure. OBJECTIVE: To develop a simple method for the direct quantitation of the majority of AAGs (sub-types 1a and 1b) within crude extracts, using commonly available (1) H-NMR spectrometers, for food control...
January 16, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28071864/simultaneous-determination-of-four-triterpenoid-saponins-in-aralia-elata-leaves-by-hplc-elsd-combined-with-hierarchical-clustering-analysis
#14
Yichun Sun, Baimei Li, Xiaoting Lin, Juan Xue, Zhibin Wang, Hongwei Zhang, Hai Jiang, Qiuhong Wang, Haixue Kuang
INTRODUCTION: Aralia elata leaves are known to have several biological activities, including anti-arrythmia, antitumor, anti-inflammatory, anti-fatigue, antimicrobial and antiviral effects. Our previous study found that triterpenoid saponins from the leaves of A. elata had antitumor effects. Quantification of the triterpenoids is important for the quality control of A. elata leaves. OBJECTIVE: To establish high-performance liquid chromatography coupled with evaporative light scattering detection (HPLC-ELSD) for the simultaneous determination of four major triterpenoid saponins, including Aralia-saponin IV, Aralia-saponin VI, 3-O-β-d- glucopyranosyl-(1 → 3)-β-d-glucopyranosyl-(1 → 3)-β-d-glucopyranosyl oleanolic acid 28-O-β-d-glucopyranoside (Aralia-saponin TTP)and Aralia-saponin V...
January 10, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28067965/rp-hplc-dad-esi-qtof-ms-based-metabolic-profiling-of-the-potential-olea-europaea-by-product-wood-and-its-comparison-with-leaf-counterpart
#15
Sonda Ammar, Maria Del Mar Contreras, Boutheina Gargouri, Antonio Segura-Carretero, Mohamed Bouaziz
INTRODUCTION: Olea europaea L. organs such as leaves, stems and roots have been associated with numerous in vivo and in vitro biological activities and used for traditional medicinal purposes. However, tree wood is an untapped resource with little information about their chemical composition. OBJECTIVE: That is why, the objective of this study is to increase the knowledge about phytochemicals from 'Chemlali' olive wood by means of mass spectrometry-based analyses...
January 9, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28029194/reverse-iontophoretic-extraction-of-metabolites-from-living-plants-and-their-identification-by-ion-chromatography-coupled-to-high-resolution-mass-spectrometry
#16
Maria Isabel González Sánchez, James McCullagh, Richard H Guy, Richard G Compton
INTRODUCTION: The identification and characterisation of cellular metabolites has now become an important strategy to obtain insight into functional plant biology. However, the extraction of metabolites for identification and analysis is challenging and, at the present time, usually requires destruction of the plant. OBJECTIVE: To detect different plant metabolites in living plants with no pre-treatment using the combination of iontophoresis and ion-chromatography with mass spectrometry detection...
December 28, 2016: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28028887/phytochemical-analysis-of-a-cytotoxic-fraction-of-quassia-silvestris-using-lc-hr-esi-ms-n
#17
Michel Feussi Tala, Ferdinand Mouafo Talontsi, Guang-Zhi Zeng, Hippolyte Kamdem Wabo, Michael Spiteller, Ning-Hua Tan, Pierre Tane
INTRODUCTION: The genus Quassia is a promising source of secondary metabolites with biological potential including antimalarial and cytotoxic activities. Limited data are available on the phytochemistry and pharmacology of Quassia silvestris Cheek & Jongkind, a Cameroonian medicinal plant used to treat various ailments. OBJECTIVES: To carry out the bioassay-guided fractionation and LC-HR-ESI-MS analyses of the leaves extract from Q. silvestris; to purify the active fractions and isolate the major compounds using different chromatographic and spectroscopic methods...
December 28, 2016: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28028854/hplc-elsd-quantification-and-centrifugal-partition-chromatography-isolation-of-8-o-acetylharpagide-from-oxera-coronata-lamiaceae
#18
Camille Remeur, Erell Le Borgne, Léa Gauthier, Raphaël Grougnet, Brigitte Deguin, Cyril Poullain, Marc Litaudon
INTRODUCTION: Iridoid glycosides possess highly functionalised monoterpenoid aglycon with several contiguous stereocentres. For the most common, they are often present in quantities reaching several percentage of the fresh plant weight, and thus they may be regarded as starting material for the synthesis of a number of new chiral and bioactive molecules. OBJECTIVE: To quantify and to isolate 8-O-acetylharpagide (AH) from several extracts of Oxera coronata R.P.J...
December 28, 2016: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28150425/integrated-hptlc-based-methodology-for-the-tracing-of-bioactive-compounds-in-herbal-extracts-employing-multivariate-chemometrics-a-case-study-on-morus-alba
#19
Eliza Chaita, Evagelos Gikas, Nektarios Aligiannis
INTRODUCTION: In drug discovery, bioassay-guided isolation is a well-established procedure, and still the basic approach for the discovery of natural products with desired biological properties. However, in these procedures, the most laborious and time-consuming step is the isolation of the bioactive constituents. A prior identification of the compounds that contribute to the demonstrated activity of the fractions would enable the selection of proper chromatographic techniques and lead to targeted isolation...
March 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28146304/bioassay-coupled-chromatography-challenges-and-applications-in-natural-product-research
#20
EDITORIAL
Franz Bucar, Evelyn Wolfram
No abstract text is available yet for this article.
March 2017: Phytochemical Analysis: PCA
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