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Phytochemical Analysis: PCA

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https://www.readbyqxmd.com/read/29882286/qualitative-and-quantitative-analysis-of-teucrium-polium-essential-oil-components-by-gc-ms-coupled-with-mcr-and-parafac-methods
#1
Hamidreza Nikpour, Mehdi Mousavi, Hamideh Asadollahzadeh
INTRODUCTION: Teucrium polium is a herbal plant which has curative potential and pharmacological characteristics. Therefore, establishment of accurate analytical methods for characterising its active components is of prime importance. OBJECTIVE: Because of the complex nature of essential oil samples, some results of direct gas chromatography-mass spectrometry (GC-MS) analysis maybe unreliable. Therefore, GC-MS is coupled with chemometric methods to resolve experimental information taken from chromatographic peaks, and assign compounds to them more correctly...
June 7, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29808594/uplc-esi-qtof-ms-2-characterisation-of-cola-nitida-resin-fractions-with-inhibitory-effects-on-no-and-tnf-%C3%AE-released-by-lps-activated-j774-macrophage-and-on-trypanosoma-cruzi-and-leishmania-amazonensis
#2
Larissa Frankenberger, Tamara D Mora, Carolina D de Siqueira, Fabiola B Filippin-Monteiro, Milene H de Moraes, Maique W Biavatti, Mario Steindel, Louis P Sandjo
INTRODUCTION: The resin of Cola nitida is used in western Cameroon as incense for spiritual protection and during ritual ceremonies. This plant secretion has never been investigated although previous chemical and biological studies on other resins have drawn many attentions. OBJECTIVE: The resin fractions which revealed inhibitory effect on nitric oxide (NO) and tumour necrosis factor alpha (TNF-α) released by lipopolysaccharide (LPS)-activated J774 macrophage as well as on intracellular forms of Leishmania amazonensis and Trypanosoma cruzi amastigote were chemically characterised...
May 29, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29808582/dereplication-of-plant-phenolics-using-a-mass-spectrometry-database-independent-method
#3
Ricardo M Borges, Rahil Taujale, Juliana Santana de Souza, Thaís de Andrade Bezerra, Eder Lana E Silva, Ronny Herzog, Francesca V Ponce, Jean-Luc Wolfender, Arthur S Edison
INTRODUCTION: Dereplication, an approach to sidestep the efforts involved in the isolation of known compounds, is generally accepted as being the first stage of novel discoveries in natural product research. It is based on metabolite profiling analysis of complex natural extracts. OBJECTIVE: To present the application of LipidXplorer for automatic targeted dereplication of phenolics in plant crude extracts based on direct infusion high-resolution tandem mass spectrometry data...
May 29, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29785755/energy-resolved-mass-spectrometry-of-chlorogenic-acids-and-its-application-to-isomer-quantification-by-direct-infusion-tandem-mass-spectrometry
#4
Javier Hernandez, Anja Müller, Rakesh Jaiswal, Juan Z Davalos, Nikolai Kuhnert
INTRODUCTION: With the advent of high-perfomance liquid chromatography (HPLC)-tandem mass spectrometry (MS) using ion trap mass analysers it is possible to acquire unambigious structural information in particular with respect to aspects of regiochemistry and stereochemistry of organic compounds present in complex mixtures such as coffee extracts. However, HPLC-MS methods are resource extensive, laborious and lacking user friendliness. OBJECTIVE: To introduce a simple parameter - the energy threshhold for fragmentation - determined using energy resolved MS and demonstrate its value for the complete structural characterisation and even relative quantification of individual isomeric chlrogenic acids in direct infusion experiments...
May 21, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29785715/current-advances-in-screening-for-bioactive-components-from-medicinal-plants-by-affinity-ultrafiltration-mass-spectrometry
#5
Guilin Chen, Bill X Huang, Mingquan Guo
INTRODUCTION: Medicinal plants have played an important role in maintaining human health for thousands of years. However, the interactions between the active components in medicinal plants and some certain biological targets during a disease are still unclear in most cases. OBJECTIVE: To conduct the high-throughput screening for small active molecules that can interact with biological targets, which is of great theoretical significance and practical value. METHODOLOGY: The ultrafiltration mass spectrometry (UF-LC/MS) is a powerful bio-analytical method by combining affinity ultrafiltration and liquid chromatography-mass spectrometry (LC/MS), which could rapidly screen and identify small active molecules that bind to biological targets of interest at the same time...
May 21, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29770982/characterisation-of-phenolic-compounds-by-uplc-qtof-ms-ms-of-geopropolis-from-the-stingless-bee-melipona-subnitida-janda%C3%A3-ra
#6
Silvana Alves de Souza, Telma Maria Guedes da Silva, Eva Monica Sarmento da Silva, Celso Amorim Camara, Tania Maria Sarmento Silva
INTRODUCTION: Melipona subnitida Ducke (jandaíra) is a stingless bee native to north-eastern Brazil, which produces geopropolis, a mixture of beeswax, plant resins, pollens and earth that is used for sealing beehives. OBJECTIVE: To extend the knowledge on phenolic compounds in fractions obtained by C18-solid phase extraction (SPE) of nine geopropolis samples from Melipona subnitida collected at different times. METHODOLOGY: Chromatographic profiles of nine samples of geopropolis from jandaíra were analysed by ultra-performance liquid chromatography coupled with a diode array detector and quadrupole time-of-flight mass spectrometry (UPLC-DAD-QTOF-MS/MS) and combined with the use of data-independent acquisition (MSE) for the profiling and structural characterisation of the phenolic compounds...
May 17, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29732635/new-approach-for-fast-identification-of-cyclitols-by-maldi-tof-mass-spectrometry
#7
Hossam Al-Suod, Paweł Pomastowski, Magdalena Ligor, Viorica Railean-Plugaru, Bogusław Buszewski
INTRODUCTION: Alfalfa (Medicago sativa L.) is the subject of many studies due to its numerous chemical constituents and beneficial properties. Among these constituents are cyclitols, which have attracted attention due to the variety of biological properties they have. OBJECTIVE: A rapid and sensitive analytical procedure based on matrix-assisted laser desorption ionisation technique with time-of-flight and mass spectrometry (MALDI-TOF-MS) analysis was used for the first time for the identification of three cyclitols from different parts of alfalfa...
May 6, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29691915/statistical-mixture-design-investigation-for-extraction-and-quantitation-of-aporphine-alkaloids-from-the-leaves-of-unonopsis-duckei-r-e-fr-by-hplc-ms-ms
#8
Pablo R N Rocha, Flávio A de Freitas, Célio F F Angolini, Lucas-Smith F Vasconcelos, Alaíde L B da Silva, Emmanoel V Costa, Felipe M A da Silva, Marcos N Eberlin, Giovana A Bataglion, Patrícia K Soares, Hector H F Koolen
INTRODUCTION: Alkaloids-derived drugs are a billionaire world-market and several phytochemical investigations aim the identification of new sources and/or structures. Thus, improving the way of extracting and methods to quantify them are of utmost importance. OBJECTIVE: To quantify isoquinoline-derived alkaloids in Unonopsis duckei R.E. Fr. through a new validated high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS) method in combination with a statistical mixture design that aimed a proper direct extraction of these compounds from leaves...
April 24, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29687660/recent-development-in-mass-spectrometry-and-its-hyphenated-techniques-for-the-analysis-of-medicinal-plants
#9
Ming-Zhi Zhu, Gui-Lin Chen, Jian-Lin Wu, Na Li, Zhong-Hua Liu, Ming-Quan Guo
INTRODUCTION: Medicinal plants are gaining increasing attention worldwide due to their empirical therapeutic efficacy and being a huge natural compound pool for new drug discovery and development. The efficacy, safety and quality of medicinal plants are the main concerns, which are highly dependent on the comprehensive analysis of chemical components in the medicinal plants. With the advances in mass spectrometry (MS) techniques, comprehensive analysis and fast identification of complex phytochemical components have become feasible, and may meet the needs, for the analysis of medicinal plants...
April 23, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29672972/metabolomic-profiling-and-biological-investigation-of-the-marine-sponge-derived-bacterium-rhodococcus-sp-ua13
#10
Yasmin Elsayed, John Refaat, Usama Ramadan Abdelmohsen, Eman Maher Othman, Helga Stopper, Mostafa Ahmed Fouad
INTRODUCTION: Marine sponge-associated actinomycetes are potent sources of bioactive natural products of pharmaceutical significance. They also contributed to the discovery of several clinically relevant antimicrobials. OBJECTIVE: To apply the non-targeted metabolomics approach in chemical profiling of the sponge-derived bacterium Rhodococcus sp. UA13, formerly recovered from the Red Sea sponge Callyspongia aff. Implexa, along with testing for the anti-infective potential of its different fractions...
April 19, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29667756/pharmacokinetic-profiling-of-anticancer-phytocompounds-using-computational-approach
#11
Ashish Sharma, Shilpa Sharma, Mansi Gupta, Shehnaz Fatima, Ravi Saini, Subhash Mohan Agarwal
INTRODUCTION: Natural products exhibit diverse scaffolds and are considered as suitable candidates for development of leads. However, poor pharmacokinetics often acts as a hindrance during the drug discovery process. OBJECTIVE: With a view of exploring the absorption, distribution, metabolism, excretion and toxicity (ADMET) profile of plant-based anticancer compounds, open-access databases (NPACT, CancerHSP and TaxKB) were analysed to identify molecules having properties favourable for drug ability...
April 18, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29667236/recent-advances-in-matrix-assisted-laser-desorption-ionisation-mass-spectrometry-imaging-maldi-msi-for-in-situ-analysis-of-endogenous-molecules-in-plants
#12
Liang Qin, Yawen Zhang, Yaqin Liu, Huixin He, Manman Han, Yanyan Li, Maomao Zeng, Xiaodong Wang
INTRODUCTION: Mass spectrometry imaging (MSI) as a label-free and powerful imaging technique enables in situ evaluation of a tissue metabolome and/or proteome, becoming increasingly popular in the detection of plant endogenous molecules. OBJECTIVE: The characterization of structure and spatial information of endogenous molecules in plants are both very important aspects to better understand the physiological mechanism of plant organism. METHODS: Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a commonly-used tissue imaging technique, which requires matrix to assist in situ detection of a variety of molecules on the surface of a tissue section...
April 17, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29637651/uplc-q-tof-ms-ms-guided-dereplication-of-pulsatilla-chinensis-to-identify-triterpenoid-saponins
#13
Miao-Miao Jin, Wen-Dan Zhang, Hong-Hong Jiang, Ying-Feng Du, Wei Guo, Liang Cao, Hui-Jun Xu
INTRODUCTION: Triterpenoid saponins are the major bioactive constituents of Pulsatilla chinensis, playing an important role in various biological activities such as anti-tumour, cognition-enhancing, anti-biosis, anti-inflammatory, hypoglycemic and immunological adjuvant. OBJECTIVE: To establish a systematic strategy based on ultra-high-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS) for the efficient characterisation and identification of triterpenoid saponins in crude extracts from Pulsatilla chinensis...
April 10, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29603449/qualitative-and-quantitative-analysis-of-lipo-alkaloids-and-fatty-acids-in-aconitum-carmichaelii-using-lc-ms-and-gc-ms
#14
Ying Liang, Guan-Yu Yan, Jian-Lin Wu, Xingxing Zong, Zhongqiu Liu, Hua Zhou, Liang Liu, Na Li
INTRODUCTION: Lipo-alkaloid (LA) is a kind of C19 -norditerpenoid alkaloid in Aconitum species, which usually contains an aconitane skeleton and one or two fatty acid residues. OBJECTIVE: To qualify and quantify the fatty acids and lipo-alkaloids in Aconitum carmichaelii. METHODOLOGY: An ultra-high performance liquid chromatography-triple quadrupole-mass spectrometry (UHPLC-QQQ-MS) method was established to quantify LAs, while the free fatty acids were identified by gas chromatography-mass spectrometry (GC-MS) and ultra-high performance liquid chromatography-quadrupole-time-of-flight-mass spectrometry (UHPLC-Q-TOF-MS)...
March 30, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29601658/chromatographic-characterisation-of-11-phytocannabinoids-quantitative-and-fit-to-purpose-performance-as-a-function-of-extra-column-variance
#15
Matthew Noestheden, Gareth Friedlander, Jason Anspach, Scott Krepich, K C Hyland, Wesley F Zandberg
INTRODUCTION: Cannabis sativa L. (cannabis) is utilised as a therapeutic and recreational drug. With the legalisation of cannabis in many countries and the anticipated regulation of potency that will accompany legalisation, analytical testing facilities will require a broadly applicable, quantitative, high throughput method to meet increased demand. Current analytical methods for the biologically active components of cannabis (phytocannabinoids) suffer from low throughput and/or an incomplete complement of relevant phytocannabinoids...
March 30, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29924474/advances-in-mass-spectrometry-techniques-applicable-to-phytochemical-analysis
#16
EDITORIAL
Ming-Quan Guo
No abstract text is available yet for this article.
July 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29356155/metabolic-study-of-dioecy-in-mauritia-flexuosa-nmr-based-and-chemometric-approaches
#17
Deisy Dos Santos Freitas, Glaucia Braz Alcantara
INTRODUCTION: Mauritia flexuosa is a dioecious species native to the Amazon, and the gender identification can currently be determined through the differentiation between female and male flowers in the first flowering. OBJECTIVES: To identify variations in the metabolome profiles of pooled and individual samples of leaves from female and male plants of M. flexuosa in reproductive phase, and the plant in its vegetative phase, using two extraction systems. MATERIAL AND METHODS: Extractions of leaves were separately conducted using deuterated water and methanol...
May 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29349835/optimization-of-aqueous-extraction-from-kalanchoe-pinnata-leaves-to-obtain-the-highest-content-of-an-anti-inflammatory-flavonoid-using-a-response-surface-model
#18
Luana Beatriz Dos Santos Nascimento, Paula Fernandes de Aguiar, Marcos Vinicius Leal-Costa, Marcela Araújo Soares Coutinho, Maria Paula Gonçalves Borsodi, Bartira Rossi-Bergmann, Eliana Schwartz Tavares, Sônia Soares Costa
INTRODUCTION: The medicinal plant Kalanchoe pinnata is a phenolic-rich species used worldwide. The reports on its pharmacological uses have increased by 70% in the last 10 years. The leaves of this plant are the main source of an unusual quercetin-diglycosyl flavonoid (QAR, quercetin arabinopyranosyl rhamnopyranoside), which can be easily extracted using water. QAR possess a strong in vivo anti-inflammatory activity. OBJECTIVE: To optimize the aqueous extraction of QAR from K...
May 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29336082/metabolomics-study-of-cultivated-bulbus-fritillariae-cirrhosae-at-different-growth-stages-using-uhplc-qtof-ms-coupled-with-multivariate-data-analysis
#19
Zhao Geng, YiFei Liu, Yan Gou, QinMei Zhou, ChengJun He, Li Guo, Juan Zhou, Liang Xiong
INTRODUCTION: Bulbus fritillariae cirrhosae (known as Chuān bèi mǔ in China, BFC) contain fritillaria steroidal alkaloids as the bioactive ingredients and are widely used as traditional Chinese medicine for the treatment of cough and phlegm. Due to limited wild resources, the cultivated species are becoming predominantly used in Chinese traditional medicine markets. OBJECTIVE: To assess the impact of different growth stages on the alkaloids of cultivated BFC and establish a reference for quality control and guidance for appropriate harvesting practices...
May 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29314317/quantification-of-incensole-in-three-boswellia-species-by-nir-spectroscopy-coupled-with-plsr-and-cross-validation-by-hplc
#20
Sulaiman Al-Shidhani, Najeeb Ur Rehman, Fazal Mabood, Muhammed Al-Broumi, Hidayat Hussain, Javid Hussain, Rene Csuk, Ahmed Al-Harrasi
INTRODUCTION: Incensole can be considered as a biomarker for Boswellia species which is a diterpene that has received remarkable pharmacological interest recently due to its potent anti-inflammatory and anti-depressant activity. OBJECTIVE: Near-infrared (NIR) spectroscopy coupled with PLSR (partial least squares regression) as a robust, rapid and alternative method was used to quantify the content of incensole in three species namely B. papyrifera, B. sacra and B...
May 2018: Phytochemical Analysis: PCA
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