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Amino Acids

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https://www.readbyqxmd.com/read/28204961/transglutaminase-2-a-double-face-enzyme
#1
EDITORIAL
Simone Beninati, Mauro Piacentini, Carlo M Bergamini
No abstract text is available yet for this article.
February 15, 2017: Amino Acids
https://www.readbyqxmd.com/read/28197734/non-canonical-amino-acids-bearing-thiophene-and-bithiophene-synthesis-by-an-ugi-multicomponent-reaction-and-studies-on-ion-recognition-ability
#2
Cátia I C Esteves, M Manuela M Raposo, Susana P G Costa
Novel thienyl and bithienyl amino acids with different substituents were obtained by a multicomponent Ugi reaction between a heterocyclic aldehyde, an amine, an acid and an isocyanide. Due to the presence of the sulphur heterocycle at the side chain, these unnatural amino acids are highly emissive and bear extra electron donating atoms so they were tested for their ability to act as fluorescent probes and chemosensors in the recognition of biomedically relevant ions in acetonitrile and acetonitrile/water solutions...
February 14, 2017: Amino Acids
https://www.readbyqxmd.com/read/28185014/recent-advances-on-polyproline-ii
#3
REVIEW
Tarun Jairaj Narwani, Hubert Santuz, Nicolas Shinada, Akhila Melarkode Vattekatte, Yassine Ghouzam, Narayanasamy Srinivasan, Jean-Christophe Gelly, Alexandre G de Brevern
About half of the globular proteins are composed of regular secondary structures, α-helices, and β-sheets, while the rest are constituted of irregular secondary structures, such as turns or coil conformations. Other regular secondary structures are often ignored, despite their importance in biological processes. Among such structures, the polyproline II helix (PPII) has interesting behaviours. PPIIs are not usually associated with conventional stabilizing interactions, and recent studies have observed that PPIIs are more frequent than anticipated...
February 9, 2017: Amino Acids
https://www.readbyqxmd.com/read/28175999/dietary-proteins-and-amino-acids-in-the-control-of-the-muscle-mass-during-immobilization-and-aging-role-of-the-mps-response
#4
REVIEW
Jason M Cholewa, Dominique Dardevet, Fernanda Lima-Soares, Kassiana de Araújo Pessôa, Paulo Henrique Oliveira, João Ricardo Dos Santos Pinho, Humberto Nicastro, Zhi Xia, Christian Emmanuel Torres Cabido, Nelo Eidy Zanchi
Dietary proteins/essential amino acids (EAAs) are nutrients with anabolic properties that may increase muscle mass or attenuate muscle loss during immobilization and aging via the stimulation of muscle protein synthesis (MPS). An EAA's anabolic threshold, capable to maximize the stimulation of MPS has been hypothesized, but during certain conditions associated with muscle loss, this anabolic threshold seems to increase which reduces the efficacy of dietary EAAs to stimulate MPS. Preliminary studies have demonstrated that acute ingestion of dietary proteins/EAA (with a sufficient amount of leucine) was capable to restore the postprandial MPS during bed rest, immobilization or aging; however, whether these improvements translate into chronic increases (or attenuates loss) of muscle mass is equivocal...
February 7, 2017: Amino Acids
https://www.readbyqxmd.com/read/28161800/a-strong-developmental-isotope-effect-in-caenorhabditis-elegans-induced-by-5-5-deuterated-lysine
#5
Tatyana V Korneenko, Nikolay B Pestov, Alaksiej L Hurski, Artsiom M Fedarkevich, Vadim V Shmanai, J Thomas Brenna, Mikhail S Shchepinov
Effects exerted by heavy isotope substitution in biopolymers on the functioning of whole organisms have not been investigated. We report on the decrease of permissive temperature of nematodes fed with bacteria containing 5,5-D2-lysine. We synthesized 5,5-dideuterolysine and, taking advantage of lysine being an essential amino acid, showed that C. elegans with modified lysine poorly develop from larvae into fertile adult hermaphrodites. This effect occurs only at high temperature within the permissible range for C...
February 4, 2017: Amino Acids
https://www.readbyqxmd.com/read/28161799/comprehensive-analysis-of-the-l-arginine-l-homoarginine-nitric-oxide-pathway-in-preterm-neonates-potential-roles-for-homoarginine-and-asymmetric-dimethylarginine-in-foetal-growth
#6
Anna Buck, Arslan Arinc Kayacelebi, Kristine Chobanyan-Jürgens, Sabine Illsinger, Bettina Bohnhorst, Bibiana Beckmann, Erik Hanff, Anibh M Das, Dimitrios Tsikas, Thomas Lücke
L-Arginine (Arg) and L-homoarginine (hArg) are precursors of nitric oxide (NO), a signalling molecule with multiple important roles in human organism. In the circulation of adults, high concentrations of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) and low concentrations of hArg emerged as cardiovascular risk factors. Yet, the importance of the Arg/hArg/NO pathway, especially of hArg and ADMA, in preterm neonates is little understood. We comprehensively investigated the Arg/hArg/NO pathway in 106 healthy preterm infants (51 boys, 55 girls) aged between 23 + 6 and 36 + 1 gestational weeks...
February 4, 2017: Amino Acids
https://www.readbyqxmd.com/read/28161798/behavioral-and-inflammatory-response-in-animals-exposed-to-a-low-pressure-blast-wave-and-supplemented-with-%C3%AE-alanine
#7
Jay R Hoffman, Amitai Zuckerman, Omri Ram, Oren Sadot, Jeffrey R Stout, Ishay Ostfeld, Hagit Cohen
This study investigated the benefit of β-alanine (BA) supplementation on behavioral and cognitive responses relating to mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) in rats exposed to a low-pressure blast wave. Animals were fed a normal diet with or without (PL) BA supplementation (100 mg kg(-1)) for 30-day, prior to being exposed to a low-pressure blast wave. A third group of animals served as a control (CTL). These animals were fed a normal diet, but were not exposed to the blast...
February 4, 2017: Amino Acids
https://www.readbyqxmd.com/read/28161797/contributions-of-system-a-subtypes-to-%C3%AE-methylaminoisobutyric-acid-uptake-by-placental-microvillous-membranes-of-human-and-rat
#8
Yu Takahashi, Tomohiro Nishimura, Tetsuo Maruyama, Masatoshi Tomi, Emi Nakashima
System A consists of three subtypes, sodium-coupled neutral amino acid transporter 1 (SNAT1), SNAT2, and SNAT4, which are all expressed in the placenta. The aim of this study was to evaluate the contributions of each of the three subtypes to total system A-mediated uptake in placental MVM of human and rat, using betaine and L-arginine as subtype-selective inhibitors of SNAT2 and SNAT4, respectively. Appropriate concentrations of betaine and L-arginine for subtype-selective inhibition in SNAT-overexpressing cells were identified...
February 4, 2017: Amino Acids
https://www.readbyqxmd.com/read/28161796/%C3%AE-n-methylamino-l-alanine-bmaa-perturbs-alanine-aspartate-and-glutamate-metabolism-pathways-in-human-neuroblastoma-cells-as-determined-by-metabolic-profiling
#9
Mikael K R Engskog, Lisa Ersson, Jakob Haglöf, Torbjörn Arvidsson, Curt Pettersson, Eva Brittebo
β-Methylamino-L-alanine (BMAA) is a non-proteinogenic amino acid that induces long-term cognitive deficits, as well as an increased neurodegeneration and intracellular fibril formation in the hippocampus of adult rodents following short-time neonatal exposure and in vervet monkey brain following long-term exposure. It has also been proposed to be involved in the etiology of neurodegenerative disease in humans. The aim of this study was to identify metabolic effects not related to excitotoxicity or oxidative stress in human neuroblastoma SH-SY5Y cells...
February 4, 2017: Amino Acids
https://www.readbyqxmd.com/read/28161795/a-novel-bret-based-binding-assay-for-interaction-studies-of-relaxin-family-peptide-receptor-3-with-its-ligands
#10
Jia-Hui Wang, Xiao-Xia Shao, Meng-Jun Hu, Dian Wei, Ya-Li Liu, Zeng-Guang Xu, Zhan-Yun Guo
Relaxin family peptide receptor 3 (RXFP3) is an A-class G protein-coupled receptor that is implicated in the regulation of food intake and stress response upon activation by its cognate agonist relaxin-3. To study its interaction with various ligands, we developed a novel bioluminescence resonance energy transfer (BRET)-based binding assay using the brightest NanoLuc as an energy donor and a newly developed cyan-excitable orange fluorescent protein (CyOFP) as an energy acceptor. An engineered CyOFP without intrinsic cysteine residues but with an introduced cysteine at the C-terminus was overexpressed in Escherichia coli and chemically conjugated to the A-chain N-terminus of an easily labeled chimeric R3/I5 peptide via an intermolecular disulfide linkage...
February 4, 2017: Amino Acids
https://www.readbyqxmd.com/read/28144743/structural-analyses-combined-with-small-angle-x-ray-scattering-reveals-that-the-retention-of-heme-is-critical-for-maintaining-the-structure-of-horseradish-peroxidase-under-denaturing-conditions
#11
Hyung Jin Cha, Do Soo Jang, Kyeong Sik Jin, Kwan Yong Choi
We analyzed the structure of horseradish peroxidase (HRP) under denaturing conditions of 9 M urea or 6 M guanidine hydrochloride (GdnHCl). Far-UV circular dichroism (CD) spectra indicated the existence of native-like secondary structure of holo-HRP in 9 M urea. In addition, slight changes in near-UV and Soret region CD spectra of holo-HRP in 9 M urea suggest that the tertiary structure of holo-HRP and the binding of heme remain partially intact in this condition. A transition in the thermal unfolding transition curve of holo-HRP in 9 M urea indicated the existence of a considerable amount of secondary structure...
January 31, 2017: Amino Acids
https://www.readbyqxmd.com/read/28132090/erratum-to-antifreeze-glycopeptides-from-structure-and-activity-studies-to-current-approaches-in-chemical-synthesis
#12
Małgorzata Urbańczyk, Jerzy Góra, Rafał Latajka, Norbert Sewald
No abstract text is available yet for this article.
January 28, 2017: Amino Acids
https://www.readbyqxmd.com/read/28124120/thanks-to-our-reviewers-in-2016
#13
(no author information available yet)
No abstract text is available yet for this article.
January 25, 2017: Amino Acids
https://www.readbyqxmd.com/read/28101653/effect-of-timing-of-collection-of-salivary-metabolomic-biomarkers-on-oral-cancer-detection
#14
Shigeo Ishikawa, Masahiro Sugimoto, Kenichiro Kitabatake, Micheal Tu, Ayako Sugano, Iku Yamamori, Asuka Iba, Kazuyuki Yusa, Miku Kaneko, Sana Ota, Kana Hiwatari, Ayame Enomoto, Tomita Masaru, Mitsuyoshi Iino
The aim of this study is to evaluate the effect of duration after meals for saliva collections for oral cancer detection using metabolomics. Saliva samples were collected from oral cancer patients (n = 22) and controls (n = 44). Saliva from cancer patients was collected 12 h after dinner, and 1.5 and 3.5 h after breakfast. Control subjects fasted >1.5 h prior to saliva collection. Hydrophilic metabolites were analyzed using capillary electrophoresis mass spectrometry. Levels of 51 metabolites differed significantly in controls vs...
January 18, 2017: Amino Acids
https://www.readbyqxmd.com/read/28101652/alteration-of-metabolomic-markers-of-amino-acid-metabolism-in-piglets-with-in-feed-antibiotics
#15
Chunlong Mu, Yuxiang Yang, Kaifan Yu, Miao Yu, Chuanjian Zhang, Yong Su, Weiyun Zhu
In-feed antibiotics have been used to promote growth in piglets, but its impact on metabolomics profiles associated with host metabolism is largely unknown. In this study, to test the hypothesis that antibiotic treatment may affect metabolite composition both in the gut and host biofluids, metabolomics profiles were analyzed in antibiotic-treated piglets. Piglets were fed a corn-soy basal diet with or without in-feed antibiotics from postnatal day 7 to day 42. The serum biochemical parameters, metabolomics profiles of the serum, urine, and jejunal digesta, and indicators of microbial metabolism (short-chain fatty acids and biogenic amines) were analyzed...
January 18, 2017: Amino Acids
https://www.readbyqxmd.com/read/28044206/collapsin-response-mediator-protein-2-high-resolution-crystal-structure-sheds-light-on-small-molecule-binding-post-translational-modifications-and-conformational-flexibility
#16
Matti Myllykoski, Anne Baumann, Kenneth Hensley, Petri Kursula
Collapsin response mediator protein 2 (CRMP-2) is a neuronal protein involved in axonal pathfinding. Intense research is focusing on its role in various neurological diseases. Despite a wealth of studies, not much is known about the molecular mechanisms of CRMP-2 function in vivo. The detailed structure-function relationships of CRMP-2 have also largely remained unknown, in part due to the fact that the available crystal structures lack the C-terminal tail, which is known to be a target for many post-translational modifications and protein interactions...
January 2, 2017: Amino Acids
https://www.readbyqxmd.com/read/27995330/piceatannol-attenuates-homocysteine-induced-endoplasmic-reticulum-stress-and-endothelial-cell-damage-via-heme-oxygenase-1-expression
#17
Jin-Sang Kil, Sun-Oh Jeong, Hun-Taeg Chung, Hyun-Ock Pae
A growing body of evidence implicates endoplasmic reticulum (ER)-induced cellular dysfunction and apoptosis as important factors to a variety of diseases. In endothelial cells (ECs), the sulfur-containing amino acid homocysteine (Hcy) causes EC apoptosis and reactive oxygen species (ROS) generation through induction of ER stress. Here, we have investigated whether piceatannol (Pic), a resveratrol analog, could protect ECs against Hcy-induced apoptosis, oxidative stress and ER stress, with specific emphasis on heme oxygenase-1 (HO-1)...
December 20, 2016: Amino Acids
https://www.readbyqxmd.com/read/27981415/na-h-exchanger-3-inhibitor-diminishes-the-amino-acid-enhanced-transepithelial-calcium-transport-across-the-rat-duodenum
#18
Nithipak Thammayon, Kannikar Wongdee, Kornkamon Lertsuwan, Panan Suntornsaratoon, Jirawan Thongbunchoo, Nateetip Krishnamra, Narattaphol Charoenphandhu
Na(+)/H(+) exchanger (NHE)-3 is important for intestinal absorption of nutrients and minerals, including calcium. The previous investigations have shown that the intestinal calcium absorption is also dependent on luminal nutrients, but whether aliphatic amino acids and glucose, which are abundant in the luminal fluid during a meal, similarly enhance calcium transport remains elusive. Herein, we used the in vitro Ussing chamber technique to determine epithelial electrical parameters, i.e., potential difference (PD), short-circuit current (Isc), and transepithelial resistance, as well as (45)Ca flux in the rat duodenum directly exposed on the mucosal side to glucose or various amino acids...
December 15, 2016: Amino Acids
https://www.readbyqxmd.com/read/27990559/prevention-of-hypoglycemia-induced-hippocampal-neuronal-death-by-n-acetyl-l-cysteine-nac
#19
A Ra Kho, Bo Young Choi, Jin Hee Kim, Song Hee Lee, Dae Ki Hong, Sang Hwon Lee, Jeong Hyun Jeong, Min Sohn, Sang Won Suh
Type 1 and type 2 diabetic patients who are treated with insulin or other blood glucose reducing agents for tight control of blood glucose levels are frequently at risk of experiencing severe hypoglycemia which can lead to seizures, loss of consciousness and death. Hypoglycemic neuronal cell death is not a simple result of low glucose supply to the brain, but, instead, results from a cell death signaling pathway that is started by the re-administration of glucose after glucose deprivation. Zinc is a biologically important element for physiological function of central nervous system...
February 2017: Amino Acids
https://www.readbyqxmd.com/read/27990558/comparative-proteomic-analysis-of-hemolymph-from-uninfected-and-candidatus-liberibacter-asiaticus-infected-diaphorina-citri
#20
T A Gill, C Chu, K S Pelz-Stelinski
Hemolymph was characterized from Diaphorina citri adults infected with the phytopathogen, Candidatus Liberibacter asiaticus (CLas), and compared with that from uninfected psyllids. This study identified 5531 and 3220 peptides within infected and uninfected hemolymph using nano-LC-MS/MS. A reduced number of proteins were detected for D. citri and all known endosymbionts within infected hemolymph as compared to uninfected hemolymph. A large number of immune defense proteins were absent from D. citri hemolymph; however, a single recognition protein (PGRP), two serine protease inhibitors, three prophenoloxidase (proPO) enzymes, and a single serine protease in an uninfected D...
February 2017: Amino Acids
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