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Acta Diabetologica

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https://www.readbyqxmd.com/read/29349519/agonistic-autoantibodies-against-adrenergic-receptors-correlating-with-antihypertensive-therapy-in-long-standing-diabetes-type-2
#1
LETTER
Christoph Werner, Nicolle Müller, Ulrich Alfons Müller
No abstract text is available yet for this article.
January 18, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29333578/insulin-resistance-and-bone-a-biological-partnership
#2
Caterina Conte, Solomon Epstein, Nicola Napoli
Despite a clear association between type 2 diabetes (T2D) and fracture risk, the pathogenesis of bone fragility in T2D has not been clearly elucidated. Insulin resistance is the primary defect in T2D. Insulin signalling regulates both bone formation and bone resorption, but whether insulin resistance can affect bone has not been established. On the other hand, evidence exists that bone might play a role in the regulation of glucose metabolism. This article reviews the available experimental and clinical evidence on the interplay between bone and insulin resistance...
January 15, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29330620/impact-of-sirtuin-1-expression-on-h3k56-acetylation-and-oxidative-stress-a-double-blind-randomized-controlled-trial-with-resveratrol-supplementation
#3
Simona Bo, Gabriele Togliatto, Roberto Gambino, Valentina Ponzo, Giusy Lombardo, Rosalba Rosato, Maurizio Cassader, Maria Felice Brizzi
AIMS: Sirtuin-1 (SIRT-1) down-regulation in type 2 diabetes mellitus (T2DM) has been associated with epigenetic markers of oxidative stress. We herein aim to evaluate whether an increase in SIRT-1 expression affects histone 3 acetylation at the 56 lysine residue (H3K56ac) in T2DM patients randomly selected to receive either resveratrol (40 mg or 500 mg) or a placebo for 6 months. The primary outcome is changes in the H3K56ac level by variation in SIRT-1 expression and the secondary outcome is the evidence of association between SIRT-1 level, antioxidant markers (TAS), and metabolic variables...
January 12, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29327150/levels-of-serum-uric-acid-at-admission-for-hypoglycaemia-predict-1-year-mortality
#4
Aldo Bonaventura, Fiorenza Gallo, Federico Carbone, Luca Liberale, Davide Maggi, Giovanni Sacchi, Franco Dallegri, Fabrizio Montecucco, Renzo Cordera
AIMS: Hypoglycaemia represents a critical burden with clinical and social consequences in the management of diabetes. Serum uric acid (SUA) has been associated with cardiovascular diseases (CVD), but no conclusive findings are available nowadays in patients suffering from hypoglycaemia. We investigated whether SUA levels at the time of hypoglycaemia could predict all-cause mortality after 1-year follow-up. METHODS: In total, 219 patients admitted to the Emergency Department (ED) of Ospedale Policlinico S...
January 11, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29327149/gestational-diabetes-and-risk-of-cardiovascular-disease-up-to-25%C3%A2-years-after-pregnancy-a-retrospective-cohort-study
#5
Safyer McKenzie-Sampson, Gilles Paradis, Jessica Healy-Profitós, Frédérique St-Pierre, Nathalie Auger
AIMS: The risk of cardiovascular disease in women with gestational diabetes is poorly understood. We sought to determine whether gestational diabetes increases the risk of cardiovascular disease more than two decades after pregnancy. METHODS: We carried out a retrospective cohort study of 1,070,667 women who delivered infants in hospitals within Quebec, Canada, between 1989 and 2013. We followed 67,356 women with gestational diabetes and 1,003,311 without gestational diabetes for a maximum of 25...
January 11, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29327148/autoantibodies-against-zinc-transporter-8-are-related-to-age-and-metabolic-state-in-patients-with-newly-diagnosed-autoimmune-diabetes
#6
Elżbieta Niechciał, Anita Rogowicz-Frontczak, Stanisław Piłaciński, Marta Fichna, Bogda Skowrońska, Piotr Fichna, Dorota Zozulińska-Ziółkiewicz
AIMS: To assess the prevalence of ZnT8-ab and its correlation to other autoimmune markers and diabetic ketoacidosis occurrence in children and adults with T1DM onset. METHODS: The study included 367 patients (218 children; 149 adults) at the T1DM onset. Selected diabetes-related autoantibodies such as GAD-ab, IA2-ab, ZnT8-ab were tested before the initiation of insulin therapy. Diabetic ketoacidosis was defined as glucose concentration > 13.9 mmol/l, pH < 7...
January 11, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29318370/the-metabolism-and-transport-of-1-5-anhydroglucitol-in-cells
#7
Lingwen Ying, Xiaojing Ma, Jun Yin, Yufei Wang, Xingxing He, Jiahui Peng, Yuqian Bao, Jian Zhou, Weiping Jia
AIMS: Our previous studies demonstrated that serum 1,5-anhydroglucitol (1,5-AG) levels increased slightly rather than declined after an acute glucose load. Therefore, the current study aims at exploring the transport and metabolic characteristics of 1,5-AG, as well as the effect of glucose on 1,5-AG transport. METHODS: Km and Vmax were determined to measure the affinity of glucose oxidase (GOD) and hexokinase (HK) for 1,5-AG and glucose. HepG2, C2C12, and primary mouse hepatocytes were incubated for 2 h with 1,5-AG at concentrations of 0, 80, and 160 μg/mL...
January 9, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29313102/age-affects-the-prognostic-impact-of-diabetes-in-chronic-heart-failure
#8
Filipe Manuel Cunha, Joana Pereira, Ana Ribeiro, Marta Amorim, Sérgio Silva, José Paulo Araújo, Adelino Leite-Moreira, Paulo Bettencourt, Patrícia Lourenço
AIMS: Increasing age is an established prognostic determinant in chronic heart failure (HF). Diabetes often complicates HF in its course and appears to worsen HF prognosis. A differential impact of diabetes depending on patients' age was not yet studied. We evaluated the impact of diabetes in the mortality of HF patients according to their age. METHODS: We studied a cohort of chronic ambulatory HF patients prospectively recruited. Patients were on optimized evidence-based therapy, and they were excluded if on renal replacement therapy or if they had any therapy modification or hospitalizations in the previous 2 months...
January 8, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29305766/a-novel-lips-assay-for-insulin-autoantibodies
#9
Daniela Liberati, Rebecca C Wyatt, Cristina Brigatti, Ilaria Marzinotto, Maurizio Ferrari, Elena Bazzigaluppi, Emanuele Bosi, Ben T Gillard, Kathleen M Gillespie, Frans Gorus, Ilse Weets, Eric Balti, Lorenzo Piemonti, Peter Achenbach, Alistair J K Williams, Vito Lampasona
AIMS: Insulin autoantibodies (IAA) are often the first marker of autoimmunity detected in children in the preclinical phase of type 1 diabetes (T1D). Currently, the vast majority of laboratories adopt the radiobinding micro-assay (RBA) for measuring IAA. Our aim was to replace RBA with a novel non-radioactive IAA Luciferase Immuno Precipitation System (LIPS) assay with improved performance. METHODS: We developed (pro)insulin antigens with alternative placements of a NanoLuc™ luciferase reporter (NLuc)...
January 5, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29299678/diabetes-and-number-of-years-of-life-lost-with-and-without-cardiovascular-disease-a-multi-state-homogeneous-semi-markov-model
#10
Azra Ramezankhani, Fereidoun Azizi, Farzad Hadaegh, Amir Abbas Momenan
AIMS: We quantified the impact of type 2 diabetes on incidence of non-fatal cardiovascular disease (CVD) and mortality, considering CVD as a continuum from occurrence of diabetes to the end point, and estimated the 15-year life expectancy with and without CVD. METHODS: A total of 7239 Iranian adults (3246 men), aged ≥ 30 years, were followed from 1999 to 2014. We applied a multi-state semi-Markov model with three transitions including CVD-free to non-fatal CVD, CVD-free to death and non-fatal CVD to death, and studied the influence of diabetes on each transition rate, stratifying by sex and adjusting for confounders...
January 3, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29288375/soluble-programmed-death-1-ligand-1-spd-l1-is-significantly-reduced-in-the-serum-of-type-1-diabetes-patients
#11
Xiaohong Chen, Heming Guo, Sicheng Li, Cuiping Liu, Sisi Ding, Yun Huang, Chen Fang, Ji Hu
No abstract text is available yet for this article.
December 29, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29288374/maternal-educational-level-and-the-risk-of-persistent-post-partum-glucose-metabolism-disorders-in-women-with-gestational-diabetes-mellitus
#12
Inês Gante, Ana Carina Ferreira, Gonçalo Pestana, Daniela Pires, Njila Amaral, Jorge Dores, Maria do Céu Almeida, José Luis Sandoval
AIMS: Gestational diabetes mellitus (GDM) occurs in 5-15% of pregnancies, and lower maternal educational attainment has been associated with higher risk of GDM. We aimed to determine if maternal education level is associated with persistent post-partum glucose metabolism disorders in women with GDM. METHODS: Retrospective cohort study of women with GDM followed in 25 Portuguese health institutions between 2008 and 2012. Educational attainment was categorised into four levels...
December 29, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29274011/family-history-of-diabetes-and-its-relationship-with-insulin-secretion-and-insulin-sensitivity-in-iraqi-immigrants-and-native-swedes-a-population-based-cohort-study
#13
Louise Bennet, Paul W Franks, Bengt Zöller, Leif Groop
AIMS: Middle Eastern immigrants to western countries are at high risk of developing type 2 diabetes. However, the heritability and impact of first-degree family history (FH) of type 2 diabetes on insulin secretion and action have not been adequately described. METHODS: Citizens of Malmö, Sweden, aged 30-75 years born in Iraq or Sweden were invited to participate in this population-based study. Insulin secretion (corrected insulin response and oral disposition index) and action (insulin sensitivity index) were assessed by oral glucose tolerance tests...
December 22, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29264724/advances-in-micro-and-nanotechnologies-for-the-glp-1-based-therapy-and-imaging-of-pancreatic-beta-cells
#14
Faruk H Moonschi, Corey B Hughes, George M Mussman, John L Fowlkes, Chris I Richards, Iuliana Popescu
Therapies to prevent diabetes in particular the progressive loss of β-cell mass and function and/or to improve the dysregulated metabolism associated with diabetes are highly sought. The incretin-based therapy comprising GLP-1R agonists and DPP-4 inhibitors have represented a major focus of pharmaceutical R&D over the last decade. The incretin hormone GLP-1 has powerful antihyperglycemic effect through direct stimulation of insulin biosynthesis and secretion within the β-cells; it normalizes β-cell sensitivity to glucose, has an antiapoptotic role, stimulates β-cell proliferation and differentiation, and inhibits glucagon secretion...
December 20, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29260404/new-treatment-options-for-lipid-lowering-therapy-in-subjects-with-type-2-diabetes
#15
Roberto Scicali, Antonino Di Pino, Viviana Ferrara, Francesca Urbano, Salvatore Piro, Agata Maria Rabuazzo, Francesco Purrello
Dyslipidemias represent a variety of quantitative and/or qualitative lipoprotein abnormalities. According to etiology, we distinguish primary dyslipidemias with strictly genetic background and secondary ones with their origin in other disease or pathological states. Diabetic dyslipidemia is a type of secondary dyslipidemia and plays an important role in determining the cardiovascular risk of subjects with type 2 diabetes. In these patients, insulin resistance is responsible for overproduction and secretion of atherogenic very low density lipoprotein...
December 19, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29224132/treatment-of-mild-to-moderate-hypoglycemia-in-patients-with-type-1-diabetes-treated-with-insulin-pump-therapy-are-current-recommendations-effective
#16
Véronique Gingras, Katherine Desjardins, Mohamed Raef Smaoui, Valérie Savard, Virginie Messier, Ahmad Haidar, Laurent Legault, Rémi Rabasa-Lhoret
AIMS: Mild-to-moderate hypoglycemia (blood glucose < 4.0 mmol/L) is recommended to be treated with 15 g of carbohydrates and to repeat the treatment if hypoglycemia persists after 15 min. This recommendation was established before intensive insulin therapy and based on studies using insulin with different pharmacokinetic profiles from actual insulin analogs showing that 15 g of glucose increases blood glucose by ~ 1.5 mmol/L in 15 min. We aimed to explore the effect of current recommended treatment of mild-to-moderate hypoglycemia in type 1 diabetes (T1D) participants and factors associated with treatment effectiveness...
December 9, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29218417/intensive-dietary-intervention-promoting-the-mediterranean-diet-in-people-with-high-cardiometabolic-risk-a-non-randomized-study
#17
M Grimaldi, O Ciano, M Manzo, M Rispoli, M Guglielmi, A Limardi, P Calatola, M Lucibello, S Pardo, B Capaldo, G Riccardi
AIMS: Mediterranean diet (MD) is acknowledged to exert a number of beneficial health effects. We assessed the efficacy and the durability of a 3-month intensive dietary intervention aimed at implementing the MD on body weight and cardiometabolic risk factors in subjects at high risk. METHODS: One hundred and sixteen subjects participated in the study (71 assigned to the intensive intervention and 45 to the conventional intervention). The intensive intervention consisted of 12 weekly group educational meetings and a free-of-charge supply of meals prepared according to the MD model...
December 7, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29209815/portrait-of-women-with-type-1-or-type-2-diabetes-of-childbearing-age-attending-diabetes-clinics-in-italy-the-amd-annals-initiative
#18
Marina Scavini, Maria Chiara Rossi, Marco Scardapane, Antonio Nicolucci, Valeria Manicardi, Giuseppina Russo, Paolo Di Bartolo, Carlo B Giorda, Nicoletta Musacchio, Antonio Ceriello, Stefano Genovese, Chiara Molinari, Nicoletta Dozio
AIM: To describe characteristics relevant in case of an unplanned pregnancy for T1D or T2D women of childbearing age. METHODS: We analyzed the 2011 AMD-Annals dataset, compiling information from 300 clinics (28,840 T1D patients and 532,651 T2D patients). A risk score of unfavorable conditions for pregnancy included HbA1c > 8.0%; BMI ≥ 35; systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg; microalbuminuria/proteinuria; use of statins, ACE inhibitors, ARB; use of diabetes drugs other than metformin/insulin...
December 5, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29209814/teleconsultation-in-type-1-diabetes-mellitus-telediabe
#19
Federico Bertuzzi, Ilario Stefani, Benedetta Rivolta, Basilio Pintaudi, Elena Meneghini, Livio Luzi, Antonino Mazzone
AIMS: The growing incidence of diabetes and the need to contain healthcare costs empower the necessity to identify new models of care. Telemedicine offers an acknowledged instrument to provide clinical health care at a distance, increasing patient compliance and the achievement of therapeutical goals. The objective was to test the feasibility and the efficacy in the improvement of the glycemic control of the teleconsultation for patients with type 1 diabetes mellitus. METHODS: A randomized open-label, parallel arms, controlled trial was conducted in two diabetes centers in Italy...
December 5, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29189913/association-between-multimorbidity-and-mean-platelet-volume-in-diabetic-patients-with-acute-myocardial-infarction
#20
Bartosz Hudzik, Ilona Korzonek-Szlacheta, Janusz Szkodziński, Radosław Liszka, Andrzej Lekston, Barbara Zubelewicz-Szkodzińska, Mariusz Gąsior
AIMS: Diabetes mellitus (DM) is one of the most frequently detected conditions in multimorbid disease clusters. Platelet activation is one of the key mechanisms underlying atherothrombosis in acute myocardial infarction. Available data link mean platelet volume (MPV) to poor prognosis not only in cardiovascular and non-cardiovascular disease. Given the lack of research data on the association between disease clusters and MPV, we have set out to investigate the link between multimorbidity and MPV in diabetic patients with acute myocardial infarction...
November 30, 2017: Acta Diabetologica
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