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Acta Diabetologica

Aldo Bonaventura, Fabrizio Montecucco
No abstract text is available yet for this article.
September 18, 2018: Acta Diabetologica
S Borys, A H Ludwig-Slomczynska, M Seweryn, J Hohendorff, T Koblik, J Machlowska, B Kiec-Wilk, P Wolkow, Maciej T Malecki
AIMS: Negative pressure wound therapy (NPWT) has been successfully used as a treatment for diabetic foot ulceration (DFU). Its mechanism of action on the molecular level, however, is not fully understood. We assessed the effect of NPWT on gene expression in patients with type 2 diabetes (T2DM) and DFU. METHODS: We included two cohorts of patients-individuals treated with either NPWT or standard therapy. The assignment to NWPT was non-randomized and based on wound characteristics...
September 17, 2018: Acta Diabetologica
Basilio Pintaudi, Raffaella Fresa, Mariagrazia Dalfrà, Alessandro Roberto Dodesini, Ester Vitacolonna, Andrea Tumminia, Laura Sciacca, Cristina Lencioni, Teresa Marcone, Giuseppe Lucisano, Antonio Nicolucci, Matteo Bonomo, Angela Napoli
AIMS: To assess the risk of adverse neonatal outcomes in women with gestational diabetes (GDM) by identifying subgroups of women at higher risk to recognize the characteristics most associated with an excess of risk. METHODS: Observational, retrospective, multicenter study involving consecutive women with GDM. To identify distinct and homogeneous subgroups of women at a higher risk, the RECursive Partitioning and AMalgamation (RECPAM) method was used. Overall, 2736 pregnancies complicated by GDM were analyzed...
September 17, 2018: Acta Diabetologica
Emilia Huvinen, Johan G Eriksson, Beata Stach-Lempinen, Aila Tiitinen, Saila B Koivusalo
AIMS: Gestational diabetes (GDM) affects a growing number of women and identification of individuals at risk, e.g., with risk prediction models, would be important. However, the performance of GDM risk scores has not been optimal. Here, we assess the impact of GDM heterogeneity on the performance of two top-rated GDM risk scores. METHODS: This is a substudy of the RADIEL trial-a lifestyle intervention study including women at high GDM risk. We assessed the GDM risk score by Teede and that developed by Van Leeuwen in our high-risk cohort of 510 women...
September 17, 2018: Acta Diabetologica
Giuseppe Pugliese, Massimo Porta
No abstract text is available yet for this article.
September 12, 2018: Acta Diabetologica
Zohar Landau, Shirli Abiri, Noah Gruber, Yael Levy-Shraga, Avivit Brener, Yael Lebenthal, Galia Barash, Orit Pinhas-Hamiel, Mariana Rachmiel
Unfortunately, the co-author name was misspelled as "Avivit Brenner" instead of "Avivit Brener" in the original publication and the correct author name is updated here.
September 12, 2018: Acta Diabetologica
Ju Eun Oh, Ji Hae Jun, Hye Jeong Hwang, Eun Jung Shin, Young Jun Oh, Yong Seon Choi
AIMS: Dexmedetomidine (DEX), a highly selective and potent α2-adrenergic receptor agonist, has anti-apoptotic, anti-inflammatory, and anti-oxidative stress effects in diabetes mellitus (DM) rats. The underlying molecular mechanisms and signaling pathways of diabetic cardiomyopathy remain poorly understood. This study aimed to elucidate the effect of DEX on cardiac function in DM rats. METHODS: Eight-week-old male Sprague Dawley rats were divided into three groups: control (n = 5), diabetes (DM, n = 7), and diabetes + DEX (DM + DEX, n = 10)...
September 11, 2018: Acta Diabetologica
Giovanna Castoldi, Cira R T di Gioia, Francesca Roma, Raffaella Carletti, Giuseppina Manzoni, Andrea Stella, Gianpaolo Zerbini, Gianluca Perseghin
AIMS: Compound 21 (C21), selective AT2 receptor agonist, has cardioprotective effects in experimental models of hypertension and myocardial infarction. The aims of the study was to evaluate the effect of C21, losartan, or both in Zucker diabetic fatty (ZDF) rats (type 2 diabetes) on (1) the prevention of myocardial hypertrophy; (2) myocardial expression of phosphatase and tensin homolog (PTEN), a target gene of miR-30a-3p, involved in myocardial remodelling. METHODS: Experiments were performed in ZDF (n = 33) and in control Lean (8) rats...
September 5, 2018: Acta Diabetologica
Isabel Ibarra-González, Ivette Cruz-Bautista, Omar Yaxmehen Bello-Chavolla, Marcela Vela-Amieva, Rigoberto Pallares-Méndez, Diana Ruiz de Santiago Y Nevarez, María Fernanda Salas-Tapia, Ximena Rosas-Flota, Mayela González-Acevedo, Adriana Palacios-Peñaloza, Mario Morales-Esponda, Carlos Alberto Aguilar-Salinas, Laura Del Bosque-Plata
AIMS: Metabolomics have been used to evaluate the role of small molecules in human disease. However, the cost and complexity of the methodology and interpretation of findings have limited the transference of knowledge to clinical practice. Here, we apply a targeted metabolomics approach using samples blotted in filter paper to develop clinical-metabolomics models to detect kidney dysfunction in diabetic kidney disease (DKD). METHODS: We included healthy controls and subjects with type 2 diabetes (T2D) with and without DKD and investigated the association between metabolite concentrations in blood and urine with eGFR and albuminuria...
September 1, 2018: Acta Diabetologica
Zohar Landau, Shirli Abiri, Noah Gruber, Yael Levy-Shraga, Avivit Brener, Yael Lebenthal, Galia Barash, Orit Pinhas-Hamiel, Mariana Rachmiel
AIMS: Frequent glucose testing is required for optimal management of type 1 diabetes (T1D). Limited data are available regarding real-world experience of the novel technology for monitoring by continuous interstitial fluid glucose (IFG), using flash glucose-sensing technology (FSL-CGM). We aimed to assess the effect of FSL-CGM in a real-life clinical setting on glycemic control parameters, compliance, and adverse events among pediatric and young adult T1D patients. METHODS: This observational multi-center study assessed FSL-CGM use (6-12 months) in T1D patients (mean ± SD age 13...
August 31, 2018: Acta Diabetologica
Ebenezer S Owusu Adjah, Kausik K Ray, Sanjoy K Paul
AIM: To evaluate the risk of CVD and all-cause mortality at different BMI levels in conjunction with weight change prior to diagnosis of T2DM in a multi-ethnic population. METHODS: Longitudinal study of 51,455 patients with T2DM and without a history of comorbid diseases at diagnosis. Weight changes prior to diagnosis of T2DM were evaluated, and the risk of CVD and all-cause mortality at different BMI levels among three ethnic groups estimated using treatment effects model...
August 30, 2018: Acta Diabetologica
Taís S Assmann, Mariana Recamonde-Mendoza, Aline R Costa, Márcia Puñales, Balduíno Tschiedel, Luís H Canani, Andrea C Bauer, Daisy Crispim
AIMS: The aim of this study was to investigate a miRNA expression profile in type 1 diabetes mellitus (T1DM) patients with DKD (cases) or without this complication (controls). METHODS: Expression of 48 miRNAs was screened in plasma of 58 T1DM patients (23 controls, 18 with moderate DKD, and 17 with severe DKD) using TaqMan Low Density Array cards (Thermo Fisher Scientific). Then, five of the dysregulated miRNAs were selected for validation in an independent sample of 10 T1DM controls and 19 patients with DKD (10 with moderate DKD and 9 with severe DKD), using RT-qPCR...
August 30, 2018: Acta Diabetologica
Juan Chen, Haijian Guo, Suixia Yuan, Chen Qu, Tao Mao, Shanhu Qiu, Wei Li, Xiaohang Wang, Min Cai, Hong Sun, Bei Wang, Xiaoning Li, Zilin Sun
AIMS: Previous studies indicated that urinary glucose (UG) had a limited efficacy in diabetes screening. This study was designed to have a re-evaluation of its efficacy, taking into consideration the collection method of urine and the measurement approach for UG among Chinese adults. METHODS: This cross-sectional study enrolled a total of 7689 participants without known diabetes, who were fasted and asked to empty bladders before a 75 g glucose loading. Urine was collected 2 h post glucose loading, and UG was measured using quantitative and qualitative approaches...
August 29, 2018: Acta Diabetologica
Federico Bellavere, Eugenio Ragazzi, Nino Cristiano Chilelli, Annunziata Lapolla, Giuseppe Bax
AIMS: Cardiovascular autonomic testing is time consuming when adopting the entire Ewing battery of tests, hence, clinicians usually adopt an empirically reduced number of tests which may give controversial results. Our purpose was to examine the reliability of the cardiovascular tests most commonly used in autonomic diagnoses. METHODS: We tested 334 subjects, from an original group of 3745, who had shown an altered deep breathing test to both Lying to standing and Valsalva manoeuvre, assuming a value of postural hypotension of more than 15 mmHg as a sign of almost true dysautonomia...
August 29, 2018: Acta Diabetologica
Clive J Petry, Ken K Ong, David B Dunger
Published studies show an inconsistent association between age at menarche and the subsequent risk of developing gestational diabetes mellitus when pregnant. This systematic review and meta-analysis was performed to clarify any trends in this association in published observational population studies. We searched online databases for relevant studies, entered into them up until June 21st 2017. Five eligible studies were found and a pooled random effects dose response meta-analysis of results from these was conducted...
August 29, 2018: Acta Diabetologica
Nadine Kuniss, Michael Freyer, Nicolle Müller, Volker Kielstein, Ulrich A Müller
AIMS: The quality report of patients enrolled in the disease management programmes of North Rhine Westphalia 2016 showed prevalence of long-term complications in diabetes type 2: neuropathy 24.2%, nephropathy 12.5%, retinopathy 8.2%. The aim of this study was to assess expectations and fear of diabetes-related long-term complications in people with diabetes type 2. METHODS: We assessed expectations and fear of diabetes-related complications in 104 people with diabetes type 2 (age 67...
August 29, 2018: Acta Diabetologica
Silvia Maestroni, Gianpaolo Zerbini
It usually takes several years (in some cases, decades) for predisposed individuals to move from the onset of type 1 or type 2 diabetes to the development of microalbuminuria, the first sign of diabetic nephropathy. This long, complication-free, period represents the best possible moment to start a successful preventive strategy (primary prevention) aimed to avoid or at least to postpone the increase of albumin excretion rate. Prevention is based on understanding and counteracting the initial mechanisms leading to the development of the disease and unfortunately, in case of diabetic nephropathy, most of them remain unclear...
August 29, 2018: Acta Diabetologica
Samar Sultan
AIMS: Maternal type 2 diabetes (T2D) can result in adverse pathological outcomes to both the mother and fetus. The present study aimed to investigate the pathological effects of maternal T2D on the gene expression patterns and functions of fetal human umbilical vein endothelial cells (HUVECs), a representative of fetal vascular cells. METHODS: Cell proliferation, apoptosis, mitochondrial ROS production and cell cycle were measured using flowcytometry. Genome-wide expression was measured using Affymetrix microarray...
August 28, 2018: Acta Diabetologica
Franck Fajnkuchen, Dante Pieramici, Linda Hrarat, Anne-Laurence Best, Salomon Y Cohen, Corinne Delahaye-Mazza, Typhaine Grenet, Sylvia Nghiem-Buffet, Gabriel Quentel, Bahram Bodaghi, Audrey Giocanti-Aurégan
AIMS: Diabetic macular edema (DME) frequently presents bilaterally. In case of bilateral retinal disease, the visual impairment (VI) and the visual acuity (VA) are strongly correlated to the better eye. The aim of this study was to assess the impact of ranibizumab intravitreal injections (IVR) on VI in patients with simultaneous VA loss due to DME. METHODS: This was a retrospective two-center study including consecutive DME patients with visual loss treated with ranibizumab since November 2011 and with a minimum follow-up of 6 months...
August 28, 2018: Acta Diabetologica
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