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Acta Diabetologica

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https://www.readbyqxmd.com/read/29151225/association-between-different-dietary-polyphenol-subclasses-and-the-improvement-in-cardiometabolic-risk-factors-evidence-from-a-randomized-controlled-clinical-trial
#1
Claudia Vetrani, Marilena Vitale, Lutgarda Bozzetto, Giuseppe Della Pepa, Sara Cocozza, Giuseppina Costabile, Anna Mangione, Paola Cipriano, Giovanni Annuzzi, Angela A Rivellese
AIMS: Due to their different chemical structures and metabolism, polyphenol subclasses may have specific impact on cardiometabolic risk factors. Our aim was to evaluate whether the intake of different polyphenol subclasses is associated with clinical outcomes beneficially improved by polyphenols in a nutritional trial performed by our group (postprandial lipid response, glucose homeostasis, early insulin secretion and oxidative stress). METHODS: The present study is a secondary analysis of a nutritional intervention study with a diet naturally rich in polyphenols...
November 18, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29151224/the-potential-role-of-the-osteopontin-osteocalcin-osteoprotegerin-triad-in-the-pathogenesis-of-prediabetes-in-humans
#2
Giuseppe Daniele, Deidre Winnier, Andrea Mari, Jan Bruder, Marcel Fourcaudot, Zuo Pengou, Andrea Hansis-Diarte, Christopher Jenkinson, Devjit Tripathy, Franco Folli
AIMS: To examine the relationship between hormones involved in bone remodeling and glucose metabolism alterations in prediabetes. METHODS: Individuals (n = 43) with NGT (BMI = 31.1 ± 1.1 kg/m(2)) and individuals (n = 79) with impaired glucose regulation (IGR) (BMI = 31.9 ± 1.2 kg/m(2)) including subjects with IFG, IGT, and IFG-IGT underwent OGTT and DXA. Osteopontin (OPN), osteocalcin (OCN), osteoprotegerin (OPG), and PTH levels were measured at fasting...
November 18, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29149381/substantial-improvement-in-hba1c-following-a-treatment-and-teaching-programme-for-people-with-type-2-diabetes-on-conventional-insulin-therapy-in-an-in-and-outpatient-setting
#3
Nadine Kuniss, Ulrich A Müller, Christof Kloos, Regina Müller, Gerd Starrach, Viktor Jörgens, Guido Kramer
AIMS: The aim of the study was to assess the efficacy of a patient education programme (DTTP) for the optimisation of conventional insulin therapy in patients with type 2 diabetes in an in- and outpatient setting. METHODS: The study was designed as a prospective, longitudinal trial. Thirty-three people with diabetes (females 54.5%, age 61.0 years, diabetes duration 12.7 years, HbA1c 9.3%) from ten general practices in Thuringia (outpatient group) participated in a DTTP for conventional insulin therapy...
November 17, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29138925/efficacy-of-self-monitoring-blood-glucose-as-a-key-component-of-a-chronic-care-model-versus-usual-care-in-type-2-diabetes-patients-treated-with-oral-agents-results-of-a-randomized-trial
#4
Nicoletta Musacchio, Ilaria Ciullo, Marco Scardapane, Annalisa Giancaterini, Laura Pessina, Silvia Maino, Rosana Gaiofatto, Antonio Nicolucci, Maria Chiara Rossi
No abstract text is available yet for this article.
November 14, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29134286/proteomic-and-metabolomic-characterization-of-streptozotocin-induced-diabetic-nephropathy-in-timp3-deficient-mice
#5
Claudia Rossi, Valeria Marzano, Ada Consalvo, Mirco Zucchelli, Stefano Levi Mortera, Viviana Casagrande, Maria Mavilio, Paolo Sacchetta, Massimo Federici, Rossella Menghini, Andrea Urbani, Domenico Ciavardelli
AIMS: The tissue inhibitor of metalloproteinase TIMP3 is a stromal protein that restrains the activity of both protease and receptor in the extracellular matrix and has been found to be down-regulated in diabetic nephropathy (DN), the leading cause of end-stage renal disease in developed countries. METHODS: In order to gain deeper insights on the association of loss of TIMP3 and DN, we performed differential proteomic analysis of kidney and blood metabolic profiling of wild-type and Timp3-knockout mice before and after streptozotocin (STZ) treatment, widely used to induce insulin deficiency and hyperglycemia...
November 13, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29134285/impact-of-variations-in-duodenal-glucose-load-on-insulin-clearance-in-health-and-type-2-diabetes
#6
Chinmay S Marathe, Christopher K Rayner, Karen L Jones, Michael Horowitz
No abstract text is available yet for this article.
November 13, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29129000/health-literacy-in-type-2-diabetes-patients-a-systematic-review-of-systematic-reviews
#7
Rosario Caruso, Arianna Magon, Irene Baroni, Federica Dellafiore, Cristina Arrigoni, Francesco Pittella, Davide Ausili
Aim To summarize, critically review, and interpret the evidence related to the systematic reviews on health literacy (HL) amongst type 2 diabetes mellitus (T2DM). Methods The methodology for this study consisted of a systematic review of systematic reviews, using the PRISMA statement and flowchart to select studies, and searching on PubMed, CINAHL, Scopus, and Cochrane. The search covered the period between January 2006 and June 2016. Results From the 115 identified record by the queries, only six systematic reviews were included, following a quality evaluation using AMSTAR...
November 11, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29127490/fetuin-a-levels-and-risk-of-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis
#8
Vivian Yawei Guo, Bing Cao, Chunyan Cai, Kenneth King-Yip Cheng, Bernard Man Yung Cheung
AIMS: Fetuin-A has been linked to insulin resistance and obesity. Its role in the pathogenesis of type 2 diabetes (T2DM) has also been discussed. We aimed to investigate the prospective association of fetuin-A and the risk of T2DM in a systematic review and meta-analysis. METHODS: A systematic search of studies from the MEDLINE, EMBASE, Pubmed and Web of Science using fetuin-A, diabetes and various synonyms was conducted up to June 5, 2017. Relevant studies were extracted by two reviewers independently...
November 11, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29119249/physical-activity-levels-of-patients-with-type-2-diabetes-in-hospital-and-at-home
#9
E Pupier, C Fagour, M Tavitian, S Pezzino, V Rigalleau
No abstract text is available yet for this article.
November 9, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29101542/routine-resting-energy-expenditure-measurement-increases-effectiveness-of-dietary-intervention-in-obesity
#10
Stefano Massarini, Anna Ferrulli, Federico Ambrogi, Concetta Macrì, Ileana Terruzzi, Stefano Benedini, Livio Luzi
AIMS: Primary outcome of this observational study was to compare weight changes in two groups of overweight and obese individuals: subjects who had a diet prescribed on the base of resting energy expenditure (REE) measured by indirect calorimetry and subjects whose REE was estimated by a predictive equation. In addition, we analyzed differences in weight and metabolic parameter variation in subjects with and without an adequate to predicted REE. METHODS: We retrospectively analyzed data of 355 overweight and obese patients: 215 on a diet based on REE measured by indirect calorimetry and 140 following a diet based on REE estimated by the Harris-Benedict equation...
November 3, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29098391/fetal-sex-influences-maternal-fasting-plasma-glucose-levels-and-basal-%C3%AE-cell-function-in-pregnant-women-with-normal-glucose-tolerance
#11
Xinqian Geng, Lulu Geng, Yinan Zhang, Huijuan Lu, Yixie Shen, Ruihua Chen, Pingyan Fang, Minfang Tao, Congrong Wang, Weiping Jia
AIMS: Fetal sex has recently emerged as a new factor that is related to maternal glucose homeostasis during pregnancy. The present study aimed to investigate the effect of fetal sex on maternal glucose metabolism in women with normal glucose tolerance (NGT) during pregnancy in the Chinese population. METHODS: A total of 877 pregnant women with NGT were recruited at 24-28 weeks of gestation and underwent a 75-g oral glucose tolerance test (OGTT). Pregnant women were divided into two groups according to fetal sex...
November 2, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29098390/errors-in-insulin-treatment-management-and-risk-of-lipohypertrophy
#12
Giuseppe Maria Pozzuoli, Mario Laudato, Maria Barone, Franco Crisci, Bianca Pozzuoli
AIMS: Lipohypertrophy (LH) represents the most common skin-related complication associated with insulin therapy. Our aim is to estimate the prevalence of LH among insulin-treated patients, to identify its association with errors in insulin injection technique and storage, and the correlation between LH, risk of hypoglycemia, and glycemic control. METHODS: Consecutive patients with T1DM or T2DM, attending a diabetes clinic for a routine visit, were administered an anonymous questionnaire investigating the modalities of insulin injection, the correct use of pen device, insulin storage, and reported frequency of hypoglycemic episodes...
November 2, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29086030/new-equations-to-estimate-resting-energy-expenditure-in-obese-adults-from-body-composition
#13
Antonino De Lorenzo, Laura Di Renzo, Pietro Morini, Renata Costa de Miranda, Lorenzo Romano, Carmela Colica
AIMS: The aims of this study were: to develop new equations for predicting resting energy expenditure (REE) in obese Italian subjects according to body composition parameters; to compare them with predicted values estimated by other REE prediction equations; and to cross-validate our equations using a validation set cohort. METHODS: Four hundred patients were enrolled and divided into three groups. Besides anthropometry and REE (indirect calorimetry), total body fat and lean were evaluated by dual X-ray absorptiometry, and fat mass and fat-free mass by bioelectrical impedance analysis...
October 30, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29064047/pancreatic-imaging-using-an-antibody-fragment-targeting-the-zinc-transporter-type-8-a-direct-comparison-with-radio-iodinated-exendin-4
#14
Olof Eriksson, Olle Korsgren, Ram Kumar Selvaraju, Marjorie Mollaret, Yann de Boysson, Fabrice Chimienti, Mohamed Altai
AIM: The zinc transporter 8 (ZnT8) has been suggested as a suitable target for non-invasive visualization of the functional pancreatic beta cell mass, due to both its pancreatic beta cell restricted expression and tight involvement in insulin secretion. METHODS: In order to examine the potential of ZnT8 as a surrogate target for beta cell mass, we performed mRNA transcription analysis in pancreatic compartments. A novel ZnT8 targeting antibody fragment Ab31 was radiolabeled with iodine-125, and evaluated by in vitro autoradiography in insulinoma and pancreas as well as by in vivo biodistribution...
October 24, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29064046/hla-infections-and-inflammation-in-early-stages-of-atherosclerosis-in-children-with-type-1-diabetes
#15
Michal Odermarsky, Erkki Pesonen, Timo Sorsa, Åke Lernmark, Pirkko J Pussinen, Petru Liuba
AIMS: This prospective study focuses on risk factors for arterial damage in children with type 1 diabetes (T1D). METHODS: Eighty children and adolescents with T1D were investigated twice, approximately 2 years apart, for carotid artery intima-media thickness (cIMT) and compliance (CAC), flow-mediated dilatation (FMD) of the brachial artery, and plasma levels of matrix metalloproteinase (MMP)-8. All subjects were genotyped for HLA. The number of respiratory tract infections (RTI) during the past year was obtained by a questionnaire in 56 patients...
October 24, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29043511/implication-of-decreased-serum-complement-3-in-patients-with-diabetic-nephropathy
#16
Junlin Zhang, Yiting Wang, Rui Zhang, Hanyu Li, Qianqian Han, Ruikun Guo, Tingli Wang, Li Li, Fang Liu
AIMS: The serum complement 3 (C3) level was reduced in many patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN). However, the clinical implications of such change are still less understood. This study was aimed to explore the association between C3 level and the baseline clinicopathological characteristics and the prognosis of T2DM patients with DN. METHODS: A total of 171 T2DM patients with biopsy-proven DN who received follow-up for at least 1 year were recruited...
October 17, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29038853/arterial-ventricular-coupling-in-type-1-diabetes-arterial-stiffness-is-associated-with-impaired-global-longitudinal-strain-in-type-1-diabetes-patients-the-thousand-1-study
#17
Simone Theilade, Peter Rossing, Jan S Jensen, Magnus T Jensen
AIMS: Diabetes is associated with higher arterial stiffness-an early marker of cardiovascular disease. The coupling between arterial stiffness and myocardial function is still unresolved. We investigate associations between arterial stiffness and early myocardial impairment assessed with advanced echocardiography. METHODS: In 305 type 1 diabetes (T1D) patients without known heart disease and with normal left ventricular ejection fraction (LVEF) (biplane LVEF > 45%), we measured arterial stiffness as pulse wave velocity (PWV) and performed conventional and speckle-tracking echocardiography assessing global longitudinal strain (GLS) as a measure of systolic myocardial function...
October 16, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28988367/neonatal-diabetes-in-a-patient-with-ipex-syndrome-an-attempt-at-balancing-insulin-therapy
#18
F Romano, D Tinti, M Spada, F Barzaghi, I Rabbone
No abstract text is available yet for this article.
October 7, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28980079/gut-microbiota-aberrations-precede-diagnosis-of-gestational-diabetes-mellitus
#19
Kati Mokkala, Noora Houttu, Tero Vahlberg, Eveliina Munukka, Tapani Rönnemaa, Kirsi Laitinen
No abstract text is available yet for this article.
October 4, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28980069/evaluation-of-the-value-of-plasma-concentration-of-copeptin-in-the-first-prenatal-visit-to-diagnose-gestational-diabetes-mellitus
#20
He-Hong Ma, Shuang-Yan Yang, Pei Wang, Jun-Feng Zhang
AIMS: Gestational diabetes mellitus (GDM) is increasing worldwide. The aim of this study was to investigate whether copeptin concentrations, measured at the first prenatal visit, are associated with risk of GDM. METHODS: From July 2015 to June 2016, consecutive women who admitted to the obstetrics center of our hospital were included. Data for fasting plasma glucose and copeptin concentrations at the first prenatal visit and one-step GDM screening with 75-g oral glucose tolerance test performed between 24 and 28 weeks of gestation were collected and analyzed...
October 4, 2017: Acta Diabetologica
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