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Acta Diabetologica

Senja Masalin, Kristiina Rönö, Hannu Kautiainen, Mika Gissler, Johan G Eriksson, Merja K Laine
AIMS: To assess the relationship between body surface area (BSA) at birth and future risk for gestational diabetes mellitus (GDM). METHODS: This is an observational cohort study from Vantaa, Finland. The cohort included 1548 Finnish primiparous women, aged 15-28 years, without pre-existing diabetes, who gave birth 2009-2015. All women were born full-term and had complete information about their birth weight and length, from the Finnish Medical Birth Register. Additional data for the study were provided by individual patient health records and Statistics Finland...
November 14, 2018: Acta Diabetologica
Christopher N Ford, Mary Beth Weber, Lisa R Staimez, Ranjit M Anjana, Karthikeyan Lakshmi, Viswanathan Mohan, K M Venkat Narayan, Ranjani Harish
AIMS: Diabetes prevention interventions have been less successful in Asian Indians compared to other populations, which may be due in part to dietary differences. The objective of this study was to determine the impact of a diabetes prevention intervention on diet and risk of diabetes in Asian Indians at high risk. METHODS: Data were included from the Diabetes Community Lifestyle Improvement Program (D-CLIP), a randomized control trial to prevent diabetes in overweight/obese Asian Indian adults (20-65 years) with prediabetes...
November 13, 2018: Acta Diabetologica
Milo Gatti
No abstract text is available yet for this article.
November 11, 2018: Acta Diabetologica
Akinkunmi Paul Okekunle, Meng Zhang, Zhen Wang, Justina Ucheojor Onwuka, Xiaoyan Wu, Rennan Feng, Chunlong Li
AIM: To assess whether oral branched-chain amino acids (BCAA) supplementation exerts influence on circulating BCAA and the significance of dietary BCAA in type 2 diabetes and obesity risk. METHOD: We searched PUBMED, EMBASE and Cochrane library through June 2018 to retrieve and screen published reports for inclusion in the meta-analysis after methodological assessment. Heterogeneity of studies was evaluated using I2 statistics, while sensitivity analysis and funnel plot were used to evaluate the potential effect of individual studies on the overall estimates and publication bias, respectively, using RevMan 5...
November 9, 2018: Acta Diabetologica
Antonio E Pontiroli, Ahmed S Zakaria, Giancarlo Micheletto, Chiara Osio, Alessandro Saibene, Franco Folli
AIMS: Long-term comparisons between bariatric surgical techniques have been performed for gastric bypass (RYGB), sleeve gastrectomy (LSG), and biliopancreatic diversion (BPD) vs gastric banding (LAGB), but short-term studies (6 months-4 years) have only compared biliointestinal bypass (BIBP) and LAGB. The participating institutions regularly perform both BIBP and LAGB with a common protocol, and the aim of this retrospective study was to compare long-term effects of the two procedures on body weight, on clinical and metabolic variables, and on resolution of obesity and of diabetes...
November 9, 2018: Acta Diabetologica
Jose Suryanegara, Sophie Cassidy, Vladan Ninkovic, Dejana Popovic, Miljan Grbovic, Nduka Okwose, Michael I Trenell, Guy G MacGowan, Djordje G Jakovljevic
AIM: The present study assessed the effect of high intensity interval training on cardiac function during prolonged submaximal exercise in patients with type 2 diabetes. METHODS: Twenty-six patients with type 2 diabetes were randomized to a 12 week of high intensity interval training (3 sessions/week) or standard care control group. All patients underwent prolonged (i.e. 60 min) submaximal cardiopulmonary exercise testing (at 50% of previously assess maximal functional capacity) with non-invasive gas-exchange and haemodynamic measurements including cardiac output and stroke volume before and after the intervention...
November 1, 2018: Acta Diabetologica
Francesco Tassone, Ida Colantonio, Elena Gamarra, Laura Gianotti, Claudia Baffoni, Giampaolo Magro, Giorgio Borretta
No abstract text is available yet for this article.
October 25, 2018: Acta Diabetologica
Mitsuyoshi Takahara, Naoto Katakami, Toshihiko Shiraiwa, Katsushige Abe, Hideo Ayame, Yasuaki Ishimaru, Masahiro Iwamoto, Mitsuo Shimizu, Osamu Tomonaga, Hiroki Yokoyama, Taka-Aki Matsuoka, Iichiro Shimomura
AIMS: This study aimed to reveal health utility values for diabetic complications and treatment regimens with adjustment for glycemic control and other clinical manifestations in a diabetic population. METHODS: The EuroQol 5-Dimension 5-Level (EQ-5D-5L) health utility values for 4963 Japanese diabetic patients were analyzed using a multivariate regression model including major complications and treatment regiments (minimally adjusted model), and that additionally included glycemic control and other subjective symptoms (musculoskeletal, dental, respiratory, gastrointestinal, urinary, and cutaneous symptoms, and hearing impairment) (further adjusted model)...
October 23, 2018: Acta Diabetologica
Apolonia García-Patterson, Montserrat Balsells, Jennifer M Yamamoto, Joanne E Kellett, Ivan Solà, Ignasi Gich, Eline M van der Beek, Eran Hadar, Eurídice Castañeda-Gutiérrez, Seppo Heinonen, Moshe Hod, Kirsi Laitinen, Sjurdur F Olsen, Lucilla Poston, Ricardo Rueda, Petra Rust, Lilou van Lieshout, Bettina Schelkle, Helen R Murphy, Rosa Corcoy
No abstract text is available yet for this article.
October 17, 2018: Acta Diabetologica
Krzysztof Jeziorny, Anna Niwald, Agnieszka Moll, Katarzyna Piasecka, Aleksandra Pyziak-Skupien, Arleta Waszczykowska, Dobromiła Baranska, Beata Malachowska, Agnieszka Szadkowska, Wojciech Mlynarski, Agnieszka Zmyslowska
AIMS: Some patients with diabetic ketoacidosis develop cerebral edema (CE) in the course of type 1 diabetes mellitus (T1D), which may result in central nervous system disorders and high mortality. The imperfection of existing neuroimaging techniques for early recognition of CE forces us to search for the new and non-invasive methods. The aim of the study was to assess the usefulness of new methods (pachymetry, transorbital ultrasonography-USG, optical coherence tomography-OCT study) in the assessment of the risk of CE occurrence in children with newly diagnosed T1D...
October 16, 2018: Acta Diabetologica
Ramamoorthy Jayashri, Ulagamathesan Venkatesan, Menon Rohan, Kuppan Gokulakrishnan, Coimbatore Subramanian Shanthi Rani, Mohan Deepa, Ranjit Mohan Anjana, Viswanathan Mohan, Rajendra Pradeepa
AIMS: To determine the prevalence of vitamin B12 deficiency in an urban south Indian population in individuals with different grades of glucose tolerance. METHODS: A total of 1500 individuals [900 normal glucose tolerance (NGT), 300 prediabetes and 300 type 2 diabetes (T2DM)] who were not on vitamin B12 supplementation were randomly selected from the Chennai Urban Rural Epidemiological Study (CURES) follow-up study. Anthropometric, clinical and biochemical investigations, which included vitamin B12 , insulin, homocysteine, HbA1c and serum lipids, were measured...
October 13, 2018: Acta Diabetologica
Ameni Touati, Javier Errea-Dorronsoro, Sonia Nouri, Yosra Halleb, Arrate Pereda, Nabiha Mahdhaoui, Aida Ghith, Ali Saad, Guiomar Perez de Nanclares, Dorra H'mida Ben Brahim
AIM: 6q24-related transient neonatal diabetes mellitus (6q24-TNDM) is a rare imprinting disorder characterized by uncontrolled hyperglycemia during the first 6 months of life. The molecular etiology of 6q24-TNDM is attributable to overexpression of the paternally inherited PLAGL1 and HYMAI genes located on the 6q24 locus. One of these major defects is maternal loss of methylation (LOM) at 6q24. In addition, approximately 50% of TNDM patients that present LOM at 6q24 can also display hypomethylation at additional imprinted loci (multilocus imprinting disturbances, MLID)...
October 13, 2018: Acta Diabetologica
Norma C Segovia-Gamboa, Martha E Rodríguez-Arellano, Andrés Muñoz-Solís, Jorge E Retana-Jiménez, Germán Vargas-Ayala, Julio Granados, Marisela Jiménez-Sánchez, Carmen Sanchez-Torres
AIMS: To assess the prevalence of autoantibodies (Aab) to insulin (IAA), glutamic acid decarboxylase 65 (GADA) and insulinoma antigen 2 (IA-2A), as well as human leukocyte antigen (HLA) class II alleles, in first degree relatives (FDR) of Mexican patients with type 1 diabetes (T1D), and to explore whether these parameters mirror the low incidence of T1D in the Mexican population. METHODS: Aab titers were determined by ELISA in 425 FDR, 234 siblings, 40 offspring and 151 parents of 197 patients with T1D...
October 10, 2018: Acta Diabetologica
Giulio Marchesini, Patrizio Pasqualetti, Roberto Anichini, Salvatore Caputo, Giuseppe Memoli, Paola Ponzani, Veronica Resi, Manfredi Rizzo, Gaetano Serviddio, Giorgio Zanette
AIMS: Several drug classes are now available to achieve a satisfactory metabolic control in patients with type 2 diabetes (T2DM), but patients' preferences may differ. METHODS: In a discrete-choice experiment, we tested T2DM patients' preferences for recent antidiabetic drugs, in the event that their treatment might require intensification. The following attributes were considered: (a) route of administration; (b) type of delivery; (c) timing; (d) risk of adverse events; (e) effects on body weight...
October 10, 2018: Acta Diabetologica
Fatma Kübra Tombulturk, Tugba Soydas, Elif Yaprak Sarac, Matem Tuncdemir, Ender Coskunpinar, Erdal Polat, Serhat Sirekbasan, Gonul Kanigur-Sultuybek
AIMS: Lucilia sericata larvae have been successfully used on healing of wounds in the diabetics. However, the involvement of the extraction/secretion (ES) products of larvae in the treatment of diabetic wounds is still unknown. Activator protein-1 (AP-1) transcription, composed of c-jun and c-Fos proteins, has been shown to be the principal regulator of multiple MMP transcriptions under a variety of conditions, also in diabetic wounds. Specifically, MMP-2 and MMP-9's transcriptions are known to be modulated by AP-1...
October 9, 2018: Acta Diabetologica
Xiaojing Wang, Tong Wang, Miao Yu, Huabing Zhang, Fan Ping, Qian Zhang, Jianping Xu, Kai Feng, Xinhua Xiao
AIMS: The study aimed to screen the HNF1A and HNF4A mutation in a large Chinese cohort of high clinical suspicion of maturity-onset diabetes of the young (MODY) patients and characterize the clinical features of those patients. The performance of hsCRP as a biomarker to differentiate MODY3 from early onset T2DM was also evaluated. METHODS: A total of 74 patients with a strong clinical suspicion of MODY from 59 families and 33 newly diagnosed early-onset T2DM were included...
October 6, 2018: Acta Diabetologica
Lucien Marchand, Arnaud Thivolet, Stéphane Dalle, Karim Chikh, Sophie Reffet, Julien Vouillarmet, Nicole Fabien, Christine Cugnet-Anceau, Charles Thivolet
AIMS: Programmed cell death-1 and programmed death ligand 1 (PD-1/PD-L1) inhibitors restore antitumor immunity, but many autoimmune side-effects have been described. Diabetes mellitus is a rare complication, and little data concerning its pathophysiology and phenotype have been published. This study aimed to describe both pancreatic endocrine and exocrine functions, immunological features and change in pancreas volume in subjects with diabetes mellitus induced by PD-1 and PD-L1 inhibitors...
October 4, 2018: Acta Diabetologica
A Rouland, C Fourmont, A L Sberna, L S Aho Glele, T Mouillot, I Simoneau, B Vergès, J M Petit, Benjamin Bouillet
AIM: Protein-energy malnutrition is known to be involved in wound healing. While wound healing in patients with diabetic foot ulcers (DFU) is a complex and multifactorial process, the role of malnutrition in this case has rarely been explored. The objective of this study was to determine whether the nutritional status of diabetic patients influences the healing of DFU. METHODS: 48 patients were included in this prospective, single-center study. All patients with comorbidities or factors involving malnutrition or influencing biological measurements were excluded...
October 3, 2018: Acta Diabetologica
Matteo Monami, Antonio Silverii, Edoardo Mannucci
No abstract text is available yet for this article.
September 27, 2018: Acta Diabetologica
T I de Vries, L J Kappelle, Y van der Graaf, H W de Valk, G J de Borst, H M Nathoe, F L J Visseren, Jan Westerink
AIM: To evaluate the relationship between thyroid-stimulating hormone (TSH) levels within the normal range and the risk of type 2 diabetes mellitus (T2DM) in a cohort of patients at high cardiovascular risk, and to perform a systematic review and meta-analysis of previous studies. METHODS: We included 5542 patients without T2DM from the prospective Secondary Manifestations of ARTerial disease study with TSH levels between 0.35 and 5.0 mIU/L without anti-thyroid medication or thyroid-hormone replacement therapy...
September 27, 2018: Acta Diabetologica
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