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Acta Diabetologica

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https://www.readbyqxmd.com/read/28512677/heterogeneity-of-proliferative-markers-in-pancreatic-%C3%AE-cells-of-patients-with-severe-hypoglycemia-following-roux-en-y-gastric-bypass
#1
Mary-Elizabeth Patti, Allison B Goldfine, Jiang Hu, Dag Hoem, Anders Molven, Jeffrey Goldsmith, Wayne H Schwesinger, Stefano La Rosa, Franco Folli, Rohit N Kulkarni
AIMS: Severe postprandial hypoglycemia with neuroglycopenia is an increasingly recognized, debilitating complication of Roux-en-Y gastric bypass (RYGB) surgery. Increased secretion of insulin and incretin hormones is implicated in its pathogenesis. Histopathologic examination of pancreas has demonstrated increased islet size and/or nuclear diameter in post-RYGB patients who underwent pancreatectomy for severe refractory hypoglycemia with neuroglycopenia (RYGB + NG). We aimed to determine whether β-cell proliferation or apoptosis is altered in RYGB + NG...
May 17, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28500467/psoriasis-in-children-with-type-1-diabetes-a-new-comorbidity-to-be-considered
#2
Luisa Di Costanzo, Valentina Fattorusso, Enza Mozzillo, Angela Patrì, Roberta Di Caprio, Elena De Nitto, Nicola Balato, Adriana Franzese
No abstract text is available yet for this article.
May 13, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28497249/the-honeymoon-period-repeatedly-appears-in-two-cases-of-type-1-diabetes-mellitus
#3
Sicheng Li, Chen Fang, Yun Huang, Heming Guo, Ji Hu
No abstract text is available yet for this article.
May 11, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28478520/role-of-the-pkc%C3%AE-ii-jnk-signaling-pathway-in-acute-glucose-fluctuation-induced-apoptosis-of-rat-vascular-endothelial-cells
#4
Na Wu, Haitao Shen, Yanjun Wang, Bing He, Yongyan Zhang, Yu Bai, Runyu Du, Qiang Du, Ping Han
AIMS: The purpose of this study was to investigate the mechanism of vascular endothelial cell apoptosis induced by acute blood glucose fluctuation. METHODS: Thirty rats were assigned to three groups: normal saline (SAL group), constant high glucose (CHG group) and acute blood glucose fluctuation (AFG) group. Other forty rats were assigned to SAL group, AFG group, LY group (PKCβ inhibitor LY333531 was injected intragastrically to the rats who were under acute blood glucose fluctuation) and SP group (JNK inhibitor SP600125 was injected intraperitoneally to the rats who were under acute blood glucose fluctuation)...
May 6, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28474119/optical-coherence-tomography-angiography-analysis-of-retinal-vascular-plexuses-and-choriocapillaris-in-patients-with-type-1-diabetes-without-diabetic-retinopathy
#5
Adriano Carnevali, Riccardo Sacconi, Eleonora Corbelli, Livia Tomasso, Lea Querques, Gianpaolo Zerbini, Vincenzo Scorcia, Francesco Bandello, Giuseppe Querques
AIMS: To analyze retinal vascular plexuses and choriocapillaris by optical coherence tomography angiography (OCT-A) and retinal nerve fiber layer and ganglion cell layer (GCL) by structural optical coherence tomography (OCT) in patients with type 1 diabetes mellitus (T1DM) without diabetic retinopathy (DR). METHODS: A total of 25 eyes of 25 consecutive T1DM patients without signs of DR were prospectively recruited and compared to 25 healthy subjects (control eyes)...
May 5, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28451823/bilateral-lower-limb-edema-induced-by-rapid-improvement-of-glycemic-control-with-insulin-therapy-in-a-subject-with-poorly-controlled-type-2-diabetes
#6
LETTER
Yuki Kan, Takatoshi Anno, Fumiko Kawasaki, Maiko Takai, Ryo Shigemoto, Hideaki Kaneto, Kohei Kaku, Niro Okimoto
No abstract text is available yet for this article.
April 27, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28451822/a-novel-heterozygous-deletion-in-the-intron-8-exon-9-boundary-of-the-glucokinase-gene-in-a-chinese-pedigree-of-gck-mody
#7
Min Chen, Hua Liang, Weibin Zhou, Chengjiang Li, Jianping Weng
No abstract text is available yet for this article.
April 27, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28424924/effects-of-gw002-a-novel-recombinant-human-glucagon-like-peptide-1-glp-1-analog-fusion-protein-on-cho-recombinant-cells-and-bks-db-mice
#8
Wan-Wan Ji, Dong-An Yu, Min Fan, Meng You, You Lu, Er-Bing Li, Ning Xie, Shou-Sheng Yan
AIMS: GLP-1-based strategies have many advantages in treatment of type 2 diabetes mellitus (T2DM), but native GLP-1 has a short half-life in the circulation, which limits its clinical application. The purpose of this study was to evaluate the effects of GW002, a novel recombinant GLP-1 analog fusion protein produced by linking the human GLP-1 analog C-terminus to the N-terminus of human serum albumin via a linker, in vitro and in BKS-db mice. METHODS: To determine whether GW002 can activate the GLP-1 receptor in cells, the level of luciferase expression was evaluated in vitro...
April 19, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28421338/tailoring-pharmacotherapy-to-specific-eating-behaviours-in-obesity-can-recommendations-for-personalised-therapy-be-made-from-the-current-data
#9
Carl A Roberts, Paul Christiansen, Jason C G Halford
Pharmacotherapy provides an adjunct to behaviour modification in the management of obesity. There are a number of new drug therapies purportedly targeting appetite; liraglutide, and bupropion/naltrexone, which are European Medicines Agency and US Food and Drug Administration (FDA) approved, and lorcaserin and phentermine/topiramate, which have FDA approval only. Each of the six drugs, used singly or in combination, has distinct pharmacological, and presumably distinct behavioural, mechanisms of action, thus the potential to provide defined therapeutic options to personalise the management of obesity...
April 19, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28421336/achievement-of-metabolic-control-among-children-and-adolescents-with-type-1-diabetes-in-spain
#10
Itxaso Rica, Andrés Mingorance, Ana Lucía Gómez-Gila, María Clemente, Isabel González, María Caimari, Beatriz García-Cuartero, Raquel Barrio
AIMS: To assess metabolic control in a paediatric T1D population in Spain and analyse the rate of severe acute decompensations and chronic complications. METHODS: Data from patients treated at eight paediatric diabetes units with experienced diabetes teams between June and December 2014 were analysed in an observational prospective study. Variables included: age, sex, diabetes duration, number of follow-up visits/year, anthropometrical data, insulin treatment modalities, mean annual HbA1c and the prevalence of acute and chronic complications...
April 18, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28421335/effect-of-statins-on-hospitalization-risk-of-bacterial-infections-in-patients-with-or-without-diabetes
#11
Laura Policardo, Giuseppe Seghieri, Roberto Anichini, Paolo Francesconi
AIMS: To investigate whether statins reduce the risk to first hospitalization of bacterial infections, in patients with or without diabetes taking into account prior or incident comorbidities. METHODS: By using administrative databases, the effect of current statin use was measured on the risk of first hospitalizations due to bacterial infections in people living in Tuscany, Italy, in the period January 1, 2011-December 31, 2015, after excluding those with previous statins use...
April 18, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28409274/toward-molecular-imaging-of-the-free-fatty-acid-receptor-1
#12
Ewa Hellström-Lindahl, Ola Åberg, Cecilia Ericsson, Gavin O'Mahony, Peter Johnström, Stanko Skrtic, Olof Eriksson
AIMS: Molecular imaging of the free fatty acid receptor 1 (FFAR1) would be a valuable tool for drug development by enabling in vivo target engagement studies in human. It has also been suggested as a putative target for beta cell imaging, but the inherent lipophilicity of most FFAR1 binders produces high off-target binding, which has hampered progress in this area. The aim of this study was to generate a suitable lead compound for further PET labeling. METHODS: In order to identify a lead compound for future PET labeling for quantitative imaging of FFAR1 in human, we evaluated tritiated small molecule FFAR1 binding probes ([(3)H]AZ1, [(3)H]AZ2 and [(3)H]TAK-875) for their off-target binding, receptor density and affinity in human pancreatic tissue (islets and exocrine) and rodent insulinoma...
April 13, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28401323/exploring-single-nucleotide-polymorphisms-previously-related-to-obesity-and-metabolic-traits-in-pediatric-onset-type-2-diabetes
#13
América Liliana Miranda-Lora, Miguel Cruz, Jesús Aguirre-Hernández, Mario Molina-Díaz, Jorge Gutiérrez, Samuel Flores-Huerta, Miguel Klünder-Klünder
AIMS: To evaluate the association of 64 obesity-related polymorphisms with pediatric-onset type 2 diabetes and other glucose- and insulin-related traits in Mexican children. METHODS: Case-control and case-sibling designs were followed. We studied 99 patients with pediatric-onset type 2 diabetes, their siblings (n = 101) without diabetes, 83 unrelated pediatric controls and 137 adult controls. Genotypes were determined for 64 single nucleotide polymorphisms, and a possible association was examined between those genotypes and type 2 diabetes and other quantitative traits, after adjusting for age, sex and body mass index...
April 12, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28393277/early-screening-for-type-2-diabetes-following-gestational-diabetes-mellitus-in-france-hardly-any-impact-of-the-2010-guidelines
#14
K Goueslard, J Cottenet, A-S Mariet, P Sagot, J-M Petit, C Quantin
AIMS: Women who had gestational diabetes mellitus (GDM) have a high risk of type 2 diabetes mellitus (T2DM) in the years following pregnancy. Most follow-up screening studies have been conducted in limited geographical areas leading to large variability in the results. The aim of our investigation was to measure how the publication of guidelines affected early screening for T2DM after a pregnancy with GDM during the period 2007-2013, in France. METHODS: We conducted a retrospective cohort study in a representative sample of 1/97th of the French population using data from the "National Health Insurance Inter-Regime Information System," which collects individual hospital and non-hospital data for healthcare consumption...
April 9, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28386664/determinants-of-glomerular-filtration-rate-following-bariatric-surgery-in-individuals-with-severe-otherwise-uncomplicated-obesity-an-observational-prospective-study
#15
Marta Seghieri, Edoardo Vitolo, Livia Giannini, Eleonora Santini, Chiara Rossi, Antonio Salvati, Anna Solini
AIMS: Obesity-induced nephropathy is an established clinical entity arising from a "maladaptive" response to lipid accumulation at the nephron level. Bariatric surgery positively affects renal function, reducing or increasing glomerular filtration rate (GFR) in subjects with hyperfiltration and renal impairment, respectively. The effect of this surgery in patients with normal estimated GFR (eGFR) is less clear. METHODS: A complete clinical and biochemical assessment of 135 severely obese, otherwise healthy subjects, was obtained before Roux-en-Y gastric bypass (RYGB)...
April 6, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28361170/bilateral-chorea-ballism-and-diabetic-ketoacidosis-as-the-initial-presentation-of-a-case-with-maternally-inherited-diabetes-and-deafness
#16
Tzu-Hsiang Ko, Hsun-Hua Lee, An-Tsz Hsieh, Chaur-Jong Hu, Chih-Chung Chen
No abstract text is available yet for this article.
March 30, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28353063/the-microrna-7-mediated-reduction-in-epac-1-contributes-to-vascular-endothelial-permeability-and-enos-uncoupling-in-murine-experimental-retinopathy
#17
Veronica Garcia-Morales, Julian Friedrich, Lysanne M Jorna, Manuel Campos-Toimil, Hans-Peter Hammes, Martina Schmidt, Guido Krenning
AIMS: To investigate the consequences of oxidative stress and hypoxia on EPAC-1 expression during retinopathy. METHODS: Oxygen-induced retinopathy was induced in mice and EPAC-1 expression investigated by immunofluorescence. In silico analyses were used to identify a link between EPAC-1 expression and microRNA-7-5p in endothelial cells and confirmed by western blot analyses on cells expressing microRNA-7-5p. In vitro, endothelial cells were either incubated at 2% oxygen or transfected with microRNA-7-5p, and the effects of these treatments on EPAC-1 expression, endothelial hyperpermeability and NO production were assessed...
March 28, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28349217/modulation-of-microglia-in-the-retina-new-insights-into-diabetic-retinopathy
#18
Ana I Arroba, Ángela M Valverde
During last decades, the diagnosis of diabetes has been associated with several chronic complications such as diabetic retinopathy (DR). Recent studies of DR have revealed an inflammatory component, which precedes the detection of alterations in the visual function. During DR, the inflammatory process presents two opposite roles depending on the polarization of resident immune cells of the retina triggering proinflammatory (M1) or antiinflammatory (M2) actions. In an early stage of DR, the M2 response concurs with the M1 and is able to ameliorate inflammation and delay the progression of the disease...
March 27, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28341960/relationship-between-healthy-lifestyle-behaviors-and-cardiovascular-risk-factors-in-chinese-patients-with-type-2-diabetes-mellitus-a-subanalysis-of-the-ccmr-3b-study
#19
Yuxin Huang, Jihu Li, Xiaolin Zhu, Jiao Sun, Linong Ji, Dayi Hu, Changyu Pan, Wen Tan, Suyuan Jiang, Xiaoming Tao
AIMS: This subanalysis of a cross-sectional, nationwide study was undertaken to assess the relationship between healthy lifestyle behaviors and multiple cardiovascular risk factors among people with type 2 diabetes mellitus (T2DM). METHODS: Data collected from 25,454 participants, including demographics, lifestyle behaviors and cardiovascular risk profiles, were analyzed. Blood pressure control as well as blood glucose and blood lipid (3Bs) levels were measured as multi-risk factors for cardiovascular disease...
March 25, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28331986/renal-function-preservation-with-pioglitazone-or-with-basal-insulin-as-an-add-on-therapy-for-patients-with-type-2-diabetes-mellitus
#20
Yu-Hung Chang, Der-Wei Hwu, Dao-Ming Chang, Ling-Wang An, Chang-Hsun Hsieh, Yau-Jiunn Lee
AIMS: Clinical outcome may differ owing to the distinct pharmacological characteristics of insulin sensitizers and insulin. This study was performed to compare the metabolic and renal function changes with add-on pioglitazone treatment versus basal insulin in patients with type 2 diabetes mellitus (DM) in whom sulfonylurea and metformin regimens failed. METHODS: Patients who were consecutively managed in the diabetes comprehensive program with add-on pioglitazone or detemir/glargine treatment for at least 2 years following sulfonylurea and metformin treatment failure were included...
March 22, 2017: Acta Diabetologica
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