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Acta Diabetologica

Pi-Jun Yan, Yong Xu, Qin Wan, Jian Feng, Hua Li, Chen-Lin Gao, Jun Yang, Hai-Hua Zhong, Zhi-Hong Zhang
AIMS: Inflammation has been reported to be involved in the pathogenesis of atherosclerosis. This principal objective of this study was to investigate if the secretion of neuregulin 4 (Nrg4), a soluble protein associated with metabolic syndrome and subclinical cardiovascular disease, is correlated with the inflammation marker high-sensitivity C-reactive protein (hs-CRP) in patients with newly diagnosed type 2 diabetes mellitus (nT2DM). METHODS: A study group of 311 nT2DM patients was divided into three subgroups based on hs-CRP tertiles...
September 16, 2017: Acta Diabetologica
Xu Han, Jing Wang, Yaru Li, Hua Hu, Xiulou Li, Jing Yuan, Ping Yao, Xiaoping Miao, Sheng Wei, Youjie Wang, Yuan Liang, Xiaomin Zhang, Huan Guo, An Pan, Handong Yang, Tangchun Wu, Meian He
AIMS: The aim of this study was to develop a new risk score system to predict 5-year incident diabetes risk among middle-aged and older Chinese population. METHODS: This prospective study included 17,690 individuals derived from the Dongfeng-Tongji cohort. Participants were recruited in 2008 and were followed until October 2013. Incident diabetes was defined as self-reported clinician diagnosed diabetes, fasting glucose ≥7.0 mmol/l, or the use of insulin or oral hypoglycemic agent...
September 16, 2017: Acta Diabetologica
Francesca Valent, Laura Tonutti, Franco Grimaldi
AIMS: Hospitalized patients with comorbid diabetes mellitus may have worse outcomes than the others. We conducted a study to assess whether comorbid diabetes affects in-hospital mortality and length of stay. METHODS: For this population-based study, we analyzed the administrative databases of the Regional Health Information System of the Region Friuli Venezia Giulia, where the Hospital of Udine is located. Hospital discharge data were linked at the individual patient level with the regional Diabetes Mellitus Registry to identify diabetic patients...
September 15, 2017: Acta Diabetologica
Enza Mozzillo, Eugenio Zito, Claudio Maffeis, Elena De Nitto, Giulio Maltoni, Marco Marigliano, Stefano Zucchini, Adriana Franzese, Giuliana Valerio
AIMS: Management of type 1 diabetes mellitus (T1DM) influences several aspects of life, such as adherence to healthy lifestyle habits and health-related quality of life (HRQoL). Our aim was to evaluate the association between unhealthy lifestyle habits and HRQoL in adolescents and young adults with T1DM. METHODS: Two hundred and forty-two Caucasian patients (13-19 years) consecutively enrolled over a 12-month period in three Regional Pediatric Diabetes Centers in Italy...
September 15, 2017: Acta Diabetologica
Gang Feng, Jia-Lin Gao, Peng Zhang, Jian-Jun Huang, Li-Zhu Huang, Long Cheng, Chun Pu
AIMS: The aim of this study was to determine the activity of serum extracellular superoxide dismutase (ecSOD) in patients with type 2 diabetes mellitus (T2DM) and healthy subjects, and to determine the prospective association between baseline serum ecSOD activity and the subsequent risk of albuminuria progression in a cohort of Chinese T2DM patients. METHODS: A total of 458 T2DM patients and 100 healthy subjects were assessed. After a median follow-up of 7.7 months, 319 patients with baseline normoalbuminuria (urinary albumin-to-creatinine ratio [UACR] <30 mg/g) and 77 patients with baseline microalbuminuria (UACR = 30-299 mg/g) were divided into progression and non-progression groups according to UACR changes...
September 12, 2017: Acta Diabetologica
Olof Eriksson, Ulrika Rosenström, Ram K Selvaraju, Barbro Eriksson, Irina Velikyan
AIMS: Radiolabeled Exendin-4 has been proposed as suitable imaging marker for pancreatic beta cell mass quantification mediated by Glucagon-like peptide-1 receptor (GLP-1R). However, noticeable species variations in basal pancreatic uptake as well as uptake reduction degree due to selective beta cell ablation were observed. METHODS: In vitro and ex vivo autoradiography studies of pancreas were performed using [(177)Lu]Lu-DO3A-VS-Cys(40)-Exendin4, in order to investigate the mechanism of uptake as well as the islet uptake contrast in mouse, rat, pig, and non-human primate...
September 11, 2017: Acta Diabetologica
Ingvild M Sørensen, Geir Joner, Pål A Jenum, Anne Eskild, Sandra R Dahl, Lars C Stene
No abstract text is available yet for this article.
September 5, 2017: Acta Diabetologica
Ryo Shigemoto, Takatoshi Anno, Fumiko Kawasaki, Shintaro Irie, Masayuki Yamamoto, Shintaro Tokuoka, Hideaki Kaneto, Kohei Kaku, Niro Okimoto
No abstract text is available yet for this article.
September 5, 2017: Acta Diabetologica
Nikolaus Buchmann, Markus Scholz, Christina M Lill, Ralph Burkhardt, Rahel Eckardt, Kristina Norman, Markus Loeffler, Lars Bertram, Joachim Thiery, Elisabeth Steinhagen-Thiessen, Ilja Demuth
AIMS: Inverse relationships have been described between the largely genetically determined levels of serum/plasma lipoprotein(a) [Lp(a)], type 2 diabetes (T2D) and fasting insulin. Here, we aimed to evaluate the nature of these relationships with respect to causality. METHODS: We tested whether we could replicate the recent negative findings on causality between Lp(a) and T2D by employing the Mendelian randomization (MR) approach using cross-sectional data from three independent cohorts, Berlin Aging Study II (BASE-II; n = 2012), LIFE-Adult (n = 3281) and LIFE-Heart (n = 2816)...
September 2, 2017: Acta Diabetologica
Enagnon Kazali Alidjinou, Famara Sane, Christine Lefevre, Agathe Baras, Ilham Moumna, Ilka Engelmann, Marie-Christine Vantyghem, Didier Hober
AIMS: Enteroviruses (EV) have been associated with type 1 diabetes (T1D), but EV RNA detection has been reported in only a small proportion of T1D patients. We studied whether integrated cell culture and reverse transcription real-time PCR could improve EV detection in blood samples from patients with T1D. METHODS: Blood was collected from 13 patients with T1D. The presence of EV RNA in blood was investigated by using real-time RT-PCR. In addition, plasma and white blood cells (WBC) were inoculated to BGM and Vero cell line cultures...
August 31, 2017: Acta Diabetologica
Leire Moreno-Galdós, Joaquín Barba-Cosials, Jorge M Núñez-Córdoba
No abstract text is available yet for this article.
August 30, 2017: Acta Diabetologica
Agnieszka Zmyslowska, Wojciech Fendler, Arleta Waszczykowska, Anna Niwald, Maciej Borowiec, Piotr Jurowski, Wojciech Mlynarski
AIMS: Wolfram syndrome (WFS) is a recessively inherited monogenic form of diabetes coexisting with optic atrophy and neurodegenerative disorders with no currently recognized markers of disease progression. The aim of the study was to evaluate retinal parameters by using optical coherence tomography (OCT) in WFS patients after 2 years of follow-up and analysis of the parameters in relation to visual acuity. METHODS: OCT parameters and visual acuity were measured in 12 WFS patients and 31 individuals with type 1 diabetes...
August 30, 2017: Acta Diabetologica
Meike Köhler, Andreas Beyerlein, Kendra Vehik, Sonja Greven, Nikolaus Umlauf, Åke Lernmark, William A Hagopian, Marian Rewers, Jin-Xiong She, Jorma Toppari, Beena Akolkar, Jeffrey P Krischer, Ezio Bonifacio, Anette-G Ziegler
AIMS: The onset of clinical type 1 diabetes (T1D) is preceded by the occurrence of disease-specific autoantibodies. The level of autoantibody titers is known to be associated with progression time from the first emergence of autoantibodies to the onset of clinical symptoms, but detailed analyses of this complex relationship are lacking. We aimed to fill this gap by applying advanced statistical models. METHODS: We investigated data of 613 children from the prospective TEDDY study who were persistent positive for IAA, GADA and/or IA2A autoantibodies...
August 30, 2017: Acta Diabetologica
Davide Ausili, Monica Bulgheroni, Paola Ballatore, Claudia Specchia, Ajtena Ajdini, Sabrina Bezze, Stefania Di Mauro, Stefano Genovese
AIMS: To describe self-care of T2DM patients and to evaluate outcomes associated with self-care in T2DM patients. METHODS: A multicentre cross-sectional study was conducted on a sample of 302 randomly selected T2DM patients. Clinical and socio-demographic data were collected by medical records. The Summary of Diabetes Self-care Activities was used to measure self-care about diet, blood testing, exercise and foot care. The EQ-5D was used to measure perceived quality of life...
August 29, 2017: Acta Diabetologica
Kiyoung Kim, Eung Suk Kim, Sang Youl Rhee, Suk Chon, Jeong-Taek Woo, Seung-Young Yu
AIMS: To identify clinical characteristics and risk factors of retinal neurodegeneration represented by macular ganglion cell/inner plexiform layer (mGCIPL) thinning in patients with long-standing type 2 diabetes mellitus (T2DM). METHODS: Patients who had T2DM for >15 years were prospectively recruited from September 2014 to July 2015. Clinical data and samples were collected according to the Common Data Element and Standards of Procedure developed by the Korean Diabetes Association research council...
August 24, 2017: Acta Diabetologica
Mathieu Boniol, Miruna Dragomir, Philippe Autier, Peter Boyle
AIMS: A systematic review was conducted of randomized trials which evaluated the impact of physical activity on the change in fasting glucose and HbA1c. METHODS: A literature search was conducted in PubMed until December 2015. Studies reporting glucose or HbA1c at baseline and at the end of study were included, and the change and its variance were estimated from studies with complete data. Mixed-effect random models were used to estimate the change of fasting glucose (mg/dl) and HbA1c (%) per additional minutes of physical activity per week...
August 24, 2017: Acta Diabetologica
L Sattar, B Renneboog, G Decaux
AIMS: Patients with diabetes mellitus experience a large number of falls and bone fractures that are not related solely to complications of the disease. The purpose of our study was to determine whether transient hyperglycemia affects attentional functions and gait. METHODS: This was a case-control study. We asked 17 patients with type 1 or type 2 diabetes mellitus to perform three visual tests and one visual and auditory attention test (Phasic Alert A1-4 and A2-3, Go/No Go, Intermodal Comparison)...
August 23, 2017: Acta Diabetologica
F A Cimini, I Barchetta, A Porzia, F Mainiero, C Costantino, L Bertoccini, V Ceccarelli, S Morini, M G Baroni, A Lenzi, M G Cavallo
AIMS: Interleukin-8 (IL-8) is a chemokine involved in systemic immunity, macrophages infiltration and activation in adipose tissue and may play a significant role in the pathogenesis of type 2 diabetes (T2D) and atherosclerosis. Aims of this study were to evaluate circulating IL-8 levels in adult patients with T2D in comparison with non-diabetic subjects and to describe clinical and biochemical correlates of IL-8 concentration. METHODS: For this cross-sectional study, we enrolled 79 consecutive T2D individuals referring to our diabetes outpatient clinics at Sapienza University of Rome, and 37 sex, age and BMI comparable non-diabetic subjects as a control group...
August 23, 2017: Acta Diabetologica
Leonardo Gomes Peixoto, Renata Roland Teixeira, Danielle Diniz Vilela, Lara Naves Barbosa, Douglas Carvalho Caixeta, Simone Ramos Deconte, Fernanda de Assis de Araújo, Robinson Sabino-Silva, Foued Salmen Espindola
AIMS: Inflammation induced by hyperglycemia triggers the toll-like receptor (TLR) pathway into cells. Our hypothesis was that metformin treatment attenuates the TLR signaling pathways triggered by inflammation in skeletal muscle of hypoinsulinemic/hyperglycemic STZ-induced rats. Thus, we examined TLR signaling under hypoinsulinemia and hyperglycemia conditions and its correlation with insulin resistance in muscle of diabetic rats treated with metformin. METHODS: Ten-day diabetic rats were submitted to 7 days of saline (D group) or metformin (500 mg/kg once per day) (D + M group)...
August 9, 2017: Acta Diabetologica
Tzu-Hsiang Ko, Hsun-Hua Lee, An-Tsz Hsieh, Chaur-Jong Hu, Chih-Chung Chen
No abstract text is available yet for this article.
August 1, 2017: Acta Diabetologica
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