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Acta Diabetologica

Yao Wang, Yuexing Yuan, Yanli Zhang, Chenghao Lei, Yi Zhou, Jiajia He, Zilin Sun
AIMS: Early diagnosis of diabetes yields significant clinical benefits; however, currently available diagnostic tools for community-based population are limited. This study aimed to assess the value of serum 1,5-anhydroglucitol (1,5-AG) for the diagnosis and screening of diabetes mellitus in a community-based population at high risk of diabetes. METHODS: In this diagnostic test, 1170 participants underwent a 75-g oral glucose tolerance test. Venous blood samples were collected for fasting blood glucose (FBG), 2-h postprandial blood glucose (PBG), and glycosylated hemoglobin A1c (HbA1c) measurements...
November 28, 2016: Acta Diabetologica
Gregory C Jones, Jansher Khan, Christopher A R Sainsbury
AIMS: Inpatient hypoglycaemia is common and associated with adverse outcomes. There is often increased vigilance of hypoglycaemia in inpatients with type 1 diabetes (T1DM) compared to type 2 diabetes (T2DM). We aimed to investigate this apparent discrepancy, utilising the time to repeat (TTR) capillary blood glucose (CBG) measurement as a surrogate for engagement with guidelines stating that CBG should be rechecked following intervention within 15 min of an initial CBG of <4 mmol/L...
November 28, 2016: Acta Diabetologica
Xuejiao Liu, Xinping Luo, Yu Liu, Xizhuo Sun, Chengyi Han, Lu Zhang, Bingyuan Wang, Yongcheng Ren, Yang Zhao, Dongdong Zhang, Dongsheng Hu, Ming Zhang
The magnitude of the risk of metabolic syndrome (MetS) with increased resting heart rate (RHR) has been inconsistently reported in some observational studies, and whether a dose-response relationship exists between RHR and MetS is unclear. We performed a meta-analysis including dose-response analysis to quantitatively evaluate this association in adults. We searched PubMed, Web of Knowledge, China National Knowledge Infrastructure, and WanFang databases for articles published up to April 2, 2016. A random-effects model was used to pool relative risks (RRs) and 95% confidence intervals (CIs); restricted cubic spline function was used to assess the dose-response relationship...
November 25, 2016: Acta Diabetologica
Zhenzhou Zhao, Xuejie Li, Dongdong Jian, Peiyuan Hao, Lixin Rao, Muwei Li
AIMS: The purpose of the current study was to investigate the characteristic expression of circular RNAs (circRNAs) in the peripheral blood of type 2 diabetes mellitus (T2DM) patients and their potential as diagnostic biomarkers for pre-diabetes and T2DM. METHODS: CircRNAs in the peripheral blood from six healthy individuals and six T2DM patients were collected for microarray analysis, and an independent cohort study consisting of 20 normal cases, 20 pre-diabetes patients and 20 T2DM patients was conducted to verify the five chosen circRNAs...
November 23, 2016: Acta Diabetologica
Roberto Codella, Michela Adamo, Paola Maffi, Lorenzo Piemonti, Antonio Secchi, Livio Luzi
No abstract text is available yet for this article.
November 23, 2016: Acta Diabetologica
Nicolle Müller, Kamlesh Khunti, Oliver Kuss, Ulf Lindblad, John J Nolan, Guy Ehm Rutten, Marina Trento, Massimo Porta, Johannes Roth, Guillaume Charpentier, Viktor Jörgens, Ulrich A Müller
AIMS: We used data from the GUIDANCE Study to determine the care of people with type 2 diabetes according to age and accompanying cardiovascular diseases and to assess indicators of overtreatment of glycaemia. METHODS: The GUIDANCE study was a retrospective, cross-sectional study from 2009-2010 based on the records of 7597 people in France, Belgium, Italy, the Netherlands, Sweden, UK, Ireland and Germany. We analysed the level of metabolic control achieved and blood glucose-lowering medication used in different age groups and in relation to accompanying diseases...
November 11, 2016: Acta Diabetologica
Davide Noto, Marcello Arca, Patrizia Tarugi, Angelo B Cefalù, Carlo M Barbagallo, Maurizio R Averna
Statin therapy is beneficial in reducing LDL cholesterol (LDL-C) levels and cardiovascular events, but it is associated with the risk of incident diabetes mellitus (DM). Familial hypercholesterolemia (FH) is characterized by genetically determined high levels of plasma LDL-C and a low prevalence of DM. LDL-C levels seem then inversely correlated with prevalence of DM. Familial hypobetalipoproteinemia (FHBL) represents the genetic mirror of FH in terms of LDL-C levels, very low in subjects carrying mutations of APOB, PCSK9 (FHBL1) or ANGPTL3 (FHBL2)...
November 2, 2016: Acta Diabetologica
Rui Du, Wanwan Sun, Lin Lin, Jichao Sun, Kui Peng, Yu Xu, Min Xu, Yuhong Chen, Yufang Bi, Weiqing Wang, Donghui Li, Jieli Lu
AIMS: Carbohydrate antigen (CA) 19-9 is a tumor marker for gastrointestinal and pancreatic cancers. Previous studies found that CA 19-9 was elevated in patients with diabetes, but little is known about its relationship with diabetes risk in prospective studies. Our objective was to evaluate the association between serum CA 19-9 and the risk of incident diabetes in Chinese population. METHODS: Data were obtained from a prospective cohort study among 2391 middle-aged and elderly Chinese with a median follow-up of 3...
November 2, 2016: Acta Diabetologica
Janusz Kochanowski, Radoslaw Piatkowski, Monika Budnik, Mariusz Jasik, Marek Roik, Grzegorz Opolski
No abstract text is available yet for this article.
November 2, 2016: Acta Diabetologica
Marina Trento, Stefano Merlo, Olga Durando, Serena Rapetti, Franco Cavallo, Massimo Porta
No abstract text is available yet for this article.
October 28, 2016: Acta Diabetologica
Josua Dwinovan, Alexander D Colella, Nusha Chegeni, Timothy K Chataway, Elke M Sokoya
AIMS: Type 2 diabetes (T2D) increases the risk of death associated with cardiovascular complications. However, a complete understanding of protein changes within the diabetic vasculature is still lacking. METHODS: Herein, we utilized mass spectrometry to perform vascular and urinary proteome analysis using a rat model of high-fat feeding and low-dose streptozotocin to simulate late-stage T2D. The purpose of this study was to identify aortic and urine proteins that are differentially expressed in normal and T2D rats...
October 28, 2016: Acta Diabetologica
Camille Dugardin, Olivier Briand, Véronique Touche, Marleen Schonewille, François Moreau, Cédric Le May, Albert K Groen, Bart Staels, Sophie Lestavel
AIMS: The dyslipidemia associated with type 2 diabetes is a major risk factor for the development of atherosclerosis. Trans-intestinal cholesterol excretion (TICE) has recently been shown to contribute, together with the classical hepatobiliary route, to fecal cholesterol excretion and cholesterol homeostasis. The aim of this study was to develop an in vitro cell model to investigate enterocyte-related processes of TICE. METHODS: Differentiated Caco-2/TC7 cells were grown on transwells and incubated basolaterally (blood side) with human plasma and apically (luminal side) with lipid micelles...
October 28, 2016: Acta Diabetologica
Min Wei, Yu Liu, Chunhong Wang, Chuanhua Yu, Dejia Li, Wei Zhou, Zhi-Jiang Zhang
No abstract text is available yet for this article.
October 28, 2016: Acta Diabetologica
Matteo Monami, Stefania Zannoni, Besmir Nreu, Edoardo Mannucci
No abstract text is available yet for this article.
October 22, 2016: Acta Diabetologica
Alice P S Kong, Kai Chow Choi, Jihui Zhang, Andrea Luk, Siu Ping Lam, Michael H M Chan, Ronald C W Ma, Juliana C N Chan, Yun Kwok Wing
AIMS: We aimed to explore the associations of sleep patterns during weekdays and weekends with glycemic control in patients with type 2 diabetes. METHODS: We examined the association between indices of glycemic control [glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG)] and sleep parameters (sleep duration, bedtime, and differences of sleep duration during weekdays and weekends) from adults with type 2 diabetes recruited in a prospective cohort enrolling from hospital medical clinics...
October 19, 2016: Acta Diabetologica
Amal Akour, Violet Kasabri, Nailya Boulatova, Yasser Bustanji, Randa Naffa, Dana Hyasat, Nahla Khawaja, Haidar Bustanji, Ayman Zayed, Munther Momani
AIMS: Type 2 diabetes mellitus (T2DM) and prediabetes (pre-DM) are associated with changes in levels of metabolic markers. The main aim of this study is to compare the levels of omentin, irisin, endothelin-1, nesfatin, hepatocyte growth factor (HGF), fibroblast growth factor, and oxytocin (OXT) between normoglycemic and pre-DM/T2DM obese Jordanian patients. METHODS: One hundred and ninety-eight adult Jordanian subjects were recruited. Demographic data and clinical parameters were collected...
October 18, 2016: Acta Diabetologica
Andrea E Scaramuzza, Claudia Arnaldi, Valentino Cherubini, Elvira Piccinno, Ivana Rabbone, Sonia Toni, Stefano Tumini, Gliberto Candela, Paola Cipriano, Lucia Ferrito, Lorenzo Lenzi, Davide Tinti, Ohad Cohen, Fortunato Lombardo
No abstract text is available yet for this article.
October 15, 2016: Acta Diabetologica
Davide Tinti, Salvatore Garofalo, Antonella Lezo, Jurgen Schleef, Ivana Rabbone
No abstract text is available yet for this article.
October 14, 2016: Acta Diabetologica
John E Madias
No abstract text is available yet for this article.
October 14, 2016: Acta Diabetologica
Matteo Monami, Ilaria Dicembrini, Edoardo Mannucci
No abstract text is available yet for this article.
October 11, 2016: Acta Diabetologica
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