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Acta Diabetologica

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https://www.readbyqxmd.com/read/28639064/whole-lipid-profile-and-not-only-hdl-cholesterol-is-impaired-in-children-with-coexisting-type-1-diabetes-and-untreated-celiac-disease
#1
Silvana Salardi, Giulio Maltoni, Stefano Zucchini, Dario Iafusco, Angela Zanfardino, Santino Confetto, Sonia Toni, Maximiliano Zioutas, Marco Marigliano, Vittoria Cauvin, Roberto Franceschi, Ivana Rabbone, Barbara Predieri, Riccardo Schiaffini, Alessandro Salvatoni
AIMS: Low HDL cholesterol (HDL-C) levels have been described in patients with coexisting type 1 diabetes mellitus (T1DM) and celiac disease (CD). Data on other possible lipid abnormalities that could further increase cardiovascular risk in these patients are scarce and incomplete. Aim of this retrospective multicenter study was to evaluate whole lipid profiles, besides HDL-C, in children with T1DM associated with biopsy-proven CD, and to investigate the influence of age and degree of adherence to gluten-free diet (GFD) on lipid changes...
June 21, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28634852/incidence-of-prolonged-qtc-and-severe-hypoglycemia-in-type-1-diabetes-the-eurodiab-prospective-complications-study
#2
Cristina Amione, Sara Giunti, Paolo Fornengo, Sabita S Soedamah-Muthu, Nish Chaturvedi, J H Fuller, Federica Barutta, Gabriella Gruden, Graziella Bruno
AIMS: To assess the independent role of severe hypoglycemia on 7-year cumulative incidence of prolonged QTc in a large cohort of patients with type 1 diabetes. METHODS: People with type 1 diabetes recruited by the EURODIAB Prospective Complications Study who had normal QTc were examined at baseline and after 7 years with standardized methods (n = 1415; mean age ± SD 32.1 ± 9.6 years; diabetes duration 14.2 ± 8.8 years). Hypoglycemic episodes were assessed by a questionnaire...
June 20, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28631057/diabetes-mellitus-a-risk-factor-for-seizures-in-the-elderly-a-population-based-study
#3
Marta Baviera, Maria Carla Roncaglioni, Mauro Tettamanti, Tommaso Vannini, Ida Fortino, Angela Bortolotti, Luca Merlino, Ettore Beghi
AIMS: To evaluate the association between diabetes mellitus (DM) and risk of seizures in a well-defined elderly population. METHODS: The administrative databases of the Lombardy region (a 10 million population area in Northern Italy) were used to identify persons aged 65 years or older with DM (defined by prescription of antidiabetic drugs and/or through ICD-9 CM code and/or exemption code for diabetes) during the year 2002. Seizure-free DM subjects were followed until 2012 in search of individuals with incident seizures (identified through ICD-9 CM codes for epilepsy/seizures or ATC codes for antiepileptic drugs associated with the prescription of an electroencephalogram)...
June 19, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28624898/improving-diabetes-care-at-primary-care-level-with-a-multistrategic-approach-results-of-the-diaprem-programme
#4
Mariana Prestes, Maria A Gayarre, Jorge F Elgart, Lorena Gonzalez, Enzo Rucci, Jose M Paganini, Juan J Gagliardino
AIM: To present results, 1 year postimplementation at primary care level, of an integrated diabetes care programme including systemic changes, education, registry (clinical, metabolic, and therapeutic indicators), and disease management (DIAPREM). METHODS: We randomly selected and trained 15 physicians and 15 nurses from primary care units of La Matanza County (intervention-IG) and another 15 physicians/nurses to participate as controls (control-CG). Each physician-nurse team controlled and followed up 10 patients with type 2 diabetes for 1 year; both groups used structured medical records...
June 17, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28620678/effect-of-lifestyle-improvement-program-on-the-biomarkers-of-adiposity-inflammation-and-gut-hormones-in-overweight-obese-asian-indians-with-prediabetes
#5
Kuppan Gokulakrishnan, Harish Ranjani, Mary Beth Weber, Gautam Kumar Pandey, Ranjit Mohan Anjana, Muthuswamy Balasubramanyam, Dorairaj Prabhakaran, Nikhil Tandon, K M Venkat Narayan, Viswanathan Mohan
AIMS: While lifestyle modification is known to offer several metabolic benefits, there is paucity of comprehensive data on changes in biomarkers of adiposity, inflammation as well as gut hormones. We investigated these biomarkers in overweight/obese individuals with prediabetes randomized to either 4 months of a lifestyle improvement program or standard care and followed them up for a year. METHODS: Participants [standard care and intervention arm (n = 75 each)] were randomly selected from the Diabetes Community Lifestyle Improvement Program trial...
June 15, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28612146/diabetic-neuropathic-cachexia-with-profound-autonomic-dysfunction-in-a-young-female-with-type-1-diabetes
#6
Ejiofor T Ugwu
No abstract text is available yet for this article.
June 13, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28608282/poly-adp-ribosylated-proteins-in-mononuclear-cells-from-patients-with-type-2-diabetes-identified-by-proteomic-studies
#7
Alessandra Giorgi, Italo Tempera, Giorgia Napoletani, Diego Drovandi, Cinzia Potestà, Sara Martire, Elisabetta Mandosi, Tiziana Filardi, M Eugenia Schininà, Susanna Morano, Maria d'Erme, Bruno Maras
AIMS: In diabetes, hyperglycemia increases reactive oxygen species that induce DNA damage and poly(ADP-ribose)polymerase activation. The aim of this study is to characterize the proteomic profile and the role of poly(ADP-ribosylation) in patients with type 2 diabetes. METHODS: A proteomic platform based on 2DE and MALDI-ToF spectrometry was applied to peripheral blood mononuclear cells obtained from two different cohorts in which diabetic (n = 14) and normoglycemic patients (n = 11) were enrolled...
June 12, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28603808/relationship-between-hyperbaric-oxygen-therapy-and-quality-of-life-in-participants-with-chronic-diabetic-foot-ulcers-data-from-a-randomized-controlled-trial
#8
Guowei Li, Robert B Hopkins, Mitchell A H Levine, Xuejing Jin, James M Bowen, Lehana Thabane, Ron Goeree, Ludwik Fedorko, Daria J O'Reilly
AIMS: To investigate the effect of hyperbaric oxygen therapy on health-related quality of life (HRQoL) in participants with diabetes and chronic foot ulcers. METHODS: Using data from a randomized controlled trial, we included 103 participants (49 in hyperbaric oxygen therapy group and 54 in sham group) for analyses. The primary outcome was HRQoL as measured by the EQ-5D-3L instrument, while secondary outcomes included quality of life evaluated by the Short Form 36 (SF-36) and Diabetic Foot Ulcers Scale-Short Form (DFS-SF)...
June 12, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28597135/glis3-rs7020673-and-rs10758593-polymorphisms-interact-in-the-susceptibility-for-type-1-diabetes-mellitus
#9
Guilherme C K Duarte, Tais S Assmann, Cristine Dieter, Bianca M de Souza, Daisy Crispim
AIMS: The transcription factor Gli-similar 3 (GLIS3) plays a key role in the development and maintenance of pancreatic beta cells as well as in the regulation of Insulin gene expression in adults. Accordingly, genome-wide association studies identified GLIS3 as a susceptibility locus for type 1 diabetes mellitus (T1DM) and glucose metabolism traits. Therefore, the aim of this study was to replicate the association of the rs10758593 and rs7020673 single nucleotide polymorphisms (SNPs) in the GLIS3 gene with T1DM in a Brazilian population...
June 9, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28597351/psychological-outcomes-of-injection-port-therapy-in-children-and-adolescents-with-type-1-diabetes-and-their-primary-caregivers
#10
Alda Troncone, Crescenzo Cascella, Angela Zanfardino, Antonietta Chianese, Santino Confetto, Milena Giglio, Pasquale Villano, Laura Perrone, Dario Iafusco
No abstract text is available yet for this article.
June 8, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28593362/hepatocyte-nuclear-factor-1%C3%AE-maturity-onset-diabetes-of-the-young-in-a-chinese-child-presenting-with-hyperglycemic-hyperosmolar-state
#11
Yue Luo, Zhijuan Dai, Liyi Li, Xiaoou Shan, Chaoming Wu
No abstract text is available yet for this article.
June 8, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28585044/lifestyle-tailored-interventions-for-south-asians-with-type-2-diabetes-living-in-high-income-countries-a-systematic-review
#12
Paola Ballotari, Francesca Ferrari, Luciana Ballini, Antonio Chiarenza, Valeria Manicardi, Paolo Giorgi Rossi
AIM: To summarize evidence on the effectiveness of educational interventions for type 2 diabetes control in South Asians living in high-income countries. METHODS: We systematically searched PubMed, EMBASE, Cinahl and the Cochrane Library, using Medical Subject Heading and free-text terms. The considered outcomes were: mortality, morbidity, glycaemic control, blood pressure, practice (diet, physical activity and self-care), attitudes/awareness and knowledge. Papers published up to July 2015 were considered...
June 6, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28577138/elevated-1-h-post-challenge-plasma-glucose-levels-in-subjects-with-normal-glucose-tolerance-or-impaired-glucose-tolerance-are-associated-with-whole-blood-viscosity
#13
Maria Adelaide Marini, Teresa Vanessa Fiorentino, Francesco Andreozzi, Gaia Chiara Mannino, Maria Perticone, Angela Sciacqua, Francesco Perticone, Giorgio Sesti
AIM: It has been suggested that glucose levels ≥155 mg/dl at 1-h during an oral glucose tolerance test (OGTT) may predict development of type 2 diabetes and cardiovascular events among adults with normal glucose tolerance (NGT 1 h-high). Studies showed a link between increased blood viscosity and type 2 diabetes. However, whether blood viscosity is associated with dysglycemic conditions such as NGT 1 h-high, impaired glucose tolerance (IGT) or impaired fasting glucose (IFG) is unsettled...
June 2, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28577137/ischemic-index-changes-in-diabetic-retinopathy-after-intravitreal-dexamethasone-implant-using-ultra-widefield-fluorescein-angiography-a-pilot-study
#14
Lea Querques, Mariacristina Parravano, Riccardo Sacconi, Alessandro Rabiolo, Francesco Bandello, Giuseppe Querques
AIMS: To investigate the effect of dexamethasone intravitreal implant on peripheral ischemia in patients affected by diabetic macular edema (DME). METHODS: Patients with treatment-naïve diabetic retinopathy (DR) undergoing intravitreal dexamethasone implant for DME between October 2015 and March 2017 were enrolled. Patients underwent a comprehensive ocular examination at baseline (<2 weeks before treatment) and 10 ± 2 weeks after dexamethasone implant including best-corrected visual acuity (BCVA), intraocular pressure, optical coherence tomography, ultra-widefield (UWF) retinography and UWF fluorescein angiography (UWFA)...
June 2, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28577136/genome-wide-gene-expression-profiling-reveals-that-cd274-is-up-regulated-new-onset-type-1-diabetes-mellitus
#15
Chen Fang, Yun Huang, Yufang Pei, Hong-Hong Zhang, Xiaohong Chen, Heming Guo, Sicheng Li, Xiaoyan Ji, Ji Hu
AIMS: Early studies have identified type 1 diabetes mellitus (T1DM) as a disease that is caused by the autoimmune destruction of the insulin-producing pancreatic β-cells. Genetics, environment and the immune pathogenesis of T1DM are three major pillars of T1DM research. We try to understand the changes in the gene expression profile during the pathogenesis of T1DM. METHODS: We performed a systematic search in the Gene Expression Omnibus (GEO) database for microarray studies of T1DM with samples taken at or before the T1DM onset...
June 2, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28555338/the-affective-and-somatic-side-of-depression-subtypes-of-depressive-symptoms-show-diametrically-opposed-associations-with-glycemic-control-in-people-with-type-1-diabetes
#16
Dominic Ehrmann, Andreas Schmitt, André Reimer, Thomas Haak, Bernhard Kulzer, Norbert Hermanns
AIMS: While depression has been linked to serious adverse outcomes in diabetes, associations with glycemic control are not conclusive. Inconsistencies could be due to the complex symptomatology of depression. Aim of this study was to analyze the associations of depressive subtypes with glycemic control in people with type 1 and type 2 diabetes. METHODS: Patients completed the Center for Epidemiological Studies-Depression scale which comprises affective, somatic, and anhedonic symptoms...
May 29, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28550359/team-management-of-gestational-diabetes-a-training-experience
#17
S Burlina, M G Dalfrà, S Visentin, R Valentini, F Capovilla, A Lapolla
No abstract text is available yet for this article.
May 26, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28512677/heterogeneity-of-proliferative-markers-in-pancreatic-%C3%AE-cells-of-patients-with-severe-hypoglycemia-following-roux-en-y-gastric-bypass
#18
Mary-Elizabeth Patti, Allison B Goldfine, Jiang Hu, Dag Hoem, Anders Molven, Jeffrey Goldsmith, Wayne H Schwesinger, Stefano La Rosa, Franco Folli, Rohit N Kulkarni
AIMS: Severe postprandial hypoglycemia with neuroglycopenia is an increasingly recognized, debilitating complication of Roux-en-Y gastric bypass (RYGB) surgery. Increased secretion of insulin and incretin hormones is implicated in its pathogenesis. Histopathologic examination of pancreas has demonstrated increased islet size and/or nuclear diameter in post-RYGB patients who underwent pancreatectomy for severe refractory hypoglycemia with neuroglycopenia (RYGB + NG). We aimed to determine whether β-cell proliferation or apoptosis is altered in RYGB + NG...
May 17, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28500467/psoriasis-in-children-with-type-1-diabetes-a-new-comorbidity-to-be-considered
#19
Luisa Di Costanzo, Valentina Fattorusso, Enza Mozzillo, Angela Patrì, Roberta Di Caprio, Elena De Nitto, Nicola Balato, Adriana Franzese
No abstract text is available yet for this article.
May 13, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28497249/the-honeymoon-period-repeatedly-appears-in-two-cases-of-type-1-diabetes-mellitus
#20
Sicheng Li, Chen Fang, Yun Huang, Heming Guo, Ji Hu
No abstract text is available yet for this article.
May 11, 2017: Acta Diabetologica
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