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Acta Diabetologica

Wangxin Zhang, Dan Zhao, Zixiu Meng, Huachen Wang, Kunsheng Zhao, Xia Feng, Yuejin Li, Aishe Dun, Xu Jin, Haifeng Hou
AIMS: Gestational diabetes mellitus (GDM) is a medical complication of any degree of glucose intolerance with onset or first recognition during pregnancy. Although visfatin is commonly considered to be related to GDM, studies revealed inconsistent results. This study aimed to clarify the relationship between visfatin and GDM. METHODS: The protocol for this study was registered in PROSPERO (No. CRD42018086204) in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)...
July 10, 2018: Acta Diabetologica
Pilar I Beato-Víbora, Francisco J Arroyo-Díez
No abstract text is available yet for this article.
July 10, 2018: Acta Diabetologica
Alessia Valentini, Maria Assunta Cianfarani, Livia De Meo, Pasquale Morabito, Daniele Romanello, Umberto Tarantino, Massimo Federici, Aldo Bertoli
AIMS: Patients with type 2 diabetes mellitus (T2DM) have an increased risk of fractures, despite having greater bone mineral density (BMD) than non-diabetic subjects. This has led to the hypothesis that the presence of impaired bone quality among diabetics reduces bone strength. The Fracture Risk Assessment Score (FRAX) algorithm, introduced to facilitate the evaluation of fracture risk, underestimates the risk of fracture in diabetic patients. The purpose of this study is to confirm the relationship between the degree of metabolic compensation and the 10-year probability of a major fracture or a hip osteoporotic fracture observed in our previous study and to ascertain whether glycosylated hemoglobin (HbA1c ) can improve the predictive value of FRAX in patients with T2DM...
July 6, 2018: Acta Diabetologica
Maria Angela Guzzardi, Patricia Iozzo
Obesity and type 2 diabetes are associated with greater risk of brain damage. Over the last decade, functional imaging techniques (functional magnetic resonance imaging, fMRI, positron emission tomography, PET, electroencephalography, magnetoencephalography, near infrared spectroscopy) have been exploited to better characterize behavioral and cognitive processes, by addressing cerebral reactions to a variety of stimuli or tasks, including hormones and substrates (e.g., glucose, insulin, gut peptides), environmental cues (e...
June 29, 2018: Acta Diabetologica
Noa Leybovitz-Haleluya, Tamar Wainstock, Daniella Landau, Eyal Sheiner
AIMS: The prevalence of gestational diabetes mellitus (GDM) has been increasing worldwide. We aimed to study the effect of GDM on the risk for childhood cardiovascular morbidity of the offspring. METHODS: A population-based cohort analysis was performed comparing total and different subtypes of cardiovascular related pediatric diagnoses among offspring of mothers with GDM vs. offspring of mothers with no diabetes. The analysis included all singletons born between the years 1991-2014...
June 23, 2018: Acta Diabetologica
Federico Maria Gioacchini, Roberto Albera, Massimo Re, Alfonso Scarpa, Claudia Cassandro, Ettore Cassandro
Diabetes mellitus is an independent risk factor for falling, particularly in the elderly. Due to chronic hyperglycemia and hyperinsulinemia patients with diabetes mellitus may have neurological deficits as peripheral neuropathy that is a debilitating micro-vascular complication affecting the proximal and distal peripheral sensory and motor nerves. Sensory neuropathy is prominent and represents the chief contributor to postural instability in diabetic subjects. Diabetic retinopathy is another complication consequent to a breakdown of the inner blood-retinal barrier with accumulation of extracellular fluids in the macula and growth of new vessels causing retinal detachment...
June 23, 2018: Acta Diabetologica
Cem Onur Kirac, Suleyman Hilmi Ipekci, Levent Kebapcilar
No abstract text is available yet for this article.
June 22, 2018: Acta Diabetologica
David Harry McDougal, Moses Morakortoi Darpolor, Marina Andreyevna DuVall, Elizabeth Frost Sutton, Christopher David Morrison, Kishore Murali Gadde, Leanne Maree Redman, Owen Thomas Carmichael
AIMS: Prior exposure to insulin-induced hypoglycemia was shown to increase glial acetate metabolism (GAM) during subsequent exposure to hypoglycemia in diabetic individuals. However, it remained unclear whether this effect was dependent on the disease state or the antecedent cause of hypoglycemia. We aimed to establish whether exposure to fasting-induced hypoglycemia was sufficient to produce alterations in GAM in non-diabetic individuals. METHODS: GAM was measured via carbon-13 magnetic resonance spectroscopy during infusion of [1-13 C] acetate before and after a 72-h fast in six metabolically healthy men...
June 22, 2018: Acta Diabetologica
Nazila Kassaian, Awat Feizi, Ashraf Aminorroaya, Parvaneh Jafari, Maryam Tajabadi Ebrahimi, Masoud Amini
AIMS: Probiotics and/or prebiotics could be a promising approach to improve metabolic disorders by favorably modifying the gut microbial composition. OBJECTIVES: To assess the effects of probiotics and synbiotic on glycemic indices in prediabetic individuals who are at risk of type 2 diabetes and its complications. METHODS: In a double-blind, randomized, placebo-controlled parallel-group clinical trial, 120 prediabetic adults participated and were randomly allocated to receive either probiotics or synbiotic or placebo supplements for 24 weeks...
June 22, 2018: Acta Diabetologica
Micaela Morettini, Francesco Di Nardo, Laura Burattini, Sandro Fioretti, Christian Göbl, Alexandra Kautzky-Willer, Giovanni Pacini, Andrea Tura
AIMS: Minimal model analysis of intravenous glucose tolerance test (IVGTT) data represents the reference method to assess insulin sensitivity (SI ) and glucose effectiveness (SG ) that quantify the insulin-dependent and insulin-independent processes of glucose disappearance, respectively. However, test duration (3 h) and need for modeling expertise limit the applicability of this method. Aim of this study was providing a simple predictor of SG applicable to short test (1 h), as previously done with SI ...
June 21, 2018: Acta Diabetologica
Christiane Marie Bourgin Folke Gam, Ole Hartvig Mortensen, Lea Hüche Larsen, Steen Seier Poulsen, Klaus Qvortrup, Elisabeth Reinhart Mathiesen, Peter Damm, Bjørn Quistorff
AIMS: Poor myometrial contractility has been demonstrated in women at term with diabetes and decreased muscular mitochondrial content and/or function has been extensively implicated in the progression of type 2 diabetes. Alterations of the uterine mitochondrial phenotype in pregnant women with diabetes have yet to be investigated as a causal link to decreased myometrial contractility. METHODS: Observational study of 18 women with diabetes (type 2 and gestational) scheduled for an elective Caesarean section at term with matching controls...
June 21, 2018: Acta Diabetologica
Bingqian Zhu, Laurie Quinn, Mary C Kapella, Ulf G Bronas, Eileen G Collins, Laurie Ruggiero, Chang G Park, Cynthia Fritschi
AIMS: Type 2 diabetes (T2D) is a metabolic disorder requiring intensive self-care to maintain optimal glycemic control. Sleep disturbance is common in T2D patients and likely impairs glycemic control. Our aim was to examine the relationship between sleep disturbance and self-care in adults with T2D. METHODS: This study used a correlational design. Sixty-four adults with T2D were recruited. Validated instruments were used to measure self-care, subjective sleep disturbance, and covariates (e...
June 21, 2018: Acta Diabetologica
ShadiSadat Seyyedebrahimi, Hadi Khodabandehloo, Ensieh Nasli Esfahani, Reza Meshkani
Oxidative stress plays a pivotal role in the pathogenesis of type 2 diabetes (T2D). In vitro and animal studies have shown that resveratrol exerts an antioxidant effect, but clinical trials addressing this effect in patients with T2D are limited. The aim of this study was to determine whether resveratrol supplementation affects oxidative stress markers in a randomized, placebo-controlled, double-blind clinical trial.
June 16, 2018: Acta Diabetologica
C L Nguyen, N M Pham, A H Lee, P T H Nguyen, T K Chu, A V V Ha, D V Duong, T H Duong, C W Binns
AIMS: To assess the association between physical activity (PA) during pregnancy and the prevalence of gestational diabetes mellitus (GDM) accounting for sitting time. METHODS: The study used data from a cohort study of 2030 pregnant women in Vietnam. Women were recruited from six hospitals in Ha Noi, Hai Phong, and Ho Chi Minh City. Baseline measurements including PA and GDM were taken at 24-28 weeks of gestation. PA was assessed during the past 3 months before the interview using the interviewer-administered Pregnancy Physical Activity Questionnaire...
June 14, 2018: Acta Diabetologica
A M Castellano-Guerrero, R Guerrero, F Relimpio, F Losada, M A Mangas, A Pumar, M A Martínez-Brocca
AIMS: To determine gender and age differences in the prevalence of depression and anxiety and their predictive factors in adult patients with type 1 diabetes (DM1). METHODS: Random sample of DM1 adult patients from a tertiary care hospital cohort. To evaluate the presence of depression and anxiety, psychological evaluation was performed using structured clinical interview (MINI). For the specific evaluation of fear of hypoglycemia (FH), FH-15 questionnaire was used...
June 13, 2018: Acta Diabetologica
Farzad Abdolmaleki, Ali Heidarianpour
AIMS: Glypican-4 (GPC-4) is a novel adipomyokine that enhances insulin signaling. Glycosylphosphatidylinositol-specific phospholipase D (GPLD1) is thought to release GPC-4 and is itself an insulin-regulated enzyme. Beneficial effects of exercise training and chamomile flowers extract (CFE) are shown through activation of PPARγ, which is a promising drug target in diabetes and associated with GPC-4 synthesis. This study investigated the effects of 14-week treadmill running and CFE on serum GPC-4, GPLD1, and insulin levels in streptozotocin-nicotinamide (STZ-NA)-induced diabetic rats...
June 13, 2018: Acta Diabetologica
Maurizio Delvecchio, Giuseppina Salzano, Clara Bonura, Vittoria Cauvin, Valentino Cherubini, Giuseppe d'Annunzio, Adriana Franzese, Sabrina Giglio, Valeria Grasso, Vanna Graziani, Dario Iafusco, Lorenzo Iughetti, Riccardo Lera, Claudio Maffeis, Giulio Maltoni, Vilma Mantovani, Claudia Menzaghi, Patrizia I Patera, Ivana Rabbone, Petra Reindstadler, Sabrina Scelfo, Nadia Tinto, Sonia Toni, Stefano Tumini, Fortunato Lombardo, Antonio Nicolucci, Fabrizio Barbetti
No abstract text is available yet for this article.
June 13, 2018: Acta Diabetologica
P Oriot, A Louvet, G Debugne, I Weets
No abstract text is available yet for this article.
June 6, 2018: Acta Diabetologica
Hajnalka Horváth, Illés Kovács, Gábor László Sándor, Cecília Czakó, Klaudia Mallár, Zsuzsanna Récsán, Anikó Somogyi, Zoltán Zsolt Nagy, Mónika Ecsedy
AIMS: To measure choroidal thickness (CT) in diabetic eyes and its correlation with metabolic status and the severity of diabetic retinopathy (DR). MATERIALS AND METHODS: Prospective cross-sectional study using swept-source optical coherence tomography. CT maps of 96 treatment naïve eyes of 48 patients with diabetes were compared to 46 eyes of 23 healthy controls. CT changes and their relation to diabetes, age, gender, disease duration, hypertension (HT), hemoglobin A1c level, type and severity of DR were evaluated...
June 6, 2018: Acta Diabetologica
Sunee Saetung, Hataikarn Nimitphong, Nantaporn Siwasaranond, Rungtip Sumritsopak, Panitha Jindahra, Orapitchaya Krairit, Ammarin Thakkinstian, Thunyarat Anothaisintawee, Sirimon Reutrakul
AIMS: Diabetes is linked to cognitive impairment. Sleep plays a role in memory consolidation. Sleep disturbances, commonly found in patients with diabetes, were shown to be related to cognitive dysfunction. This study explored the role of sleep in cognitive function of patients with abnormal glucose tolerance. METHODS: A total of 162 patients (81 type 2 diabetes and 81 prediabetes) participated. Sleep duration and sleep efficiency (an indicator of sleep quality) were obtained using 7-day actigraphy recordings...
June 6, 2018: Acta Diabetologica
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